Rickettsia conorii (Malish 7, NIAID Malish 7, ATCC VR-613)

Name: Rickettsia conorii (Malish 7, NIAID Malish 7, ATCC VR-613)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 167592

Type strain

Strain Designation Malish 7, NIAID Malish 7, Malish

Culture col. no. Malish 7 NIAID Malish 7 ATCC VR-613 CRIRC RCO003 Malish 1 more

NCBI tax ID(s) 781 319546

Links

Rickettsia conorii Malish 7 is a bacterium of the family Rickettsiaceae.

16S sequence Bacteria

Name and taxonomic classification

SI-ID 27156

ATCC VR-613

@ref 20215

Last LPSN update 2026-05-29 08:46:11

Domain Bacteria

Phylum Pseudomonadota

Class Alphaproteobacteria

Order Rickettsiales

Family Rickettsiaceae

Genus Rickettsia

Species Rickettsia conorii

Full scientific name Rickettsia conorii corrig. Brumpt 1932 (Approved Lists 1980)

Synonyms (1)

Rickettsia conori

Morphology

Culture and growth conditions

Physiology and metabolism

Isolation, sampling and environmental information

Taxonmaps

69479

Global distribution of 16S sequence AF541999 (>99% sequence identity) for Rickettsia from Microbeatlas

Aquatic Samples	1126
Soil Samples	494
Animal Samples	2180
Plant Samples	561
Total Samples	4361

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
20215	3	Risk group

Sequence information

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20215	Rickettsia conorii strain Malish 7 16S ribosomal RNA gene, partial sequence	AF541999	1427		781

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Rickettsia disrupts and reduces endothelial tight junction protein zonula occludens-1 in association with inflammasome activation.	Velatooru LR, Arroyave E, Rippee-Brooks MD, Burch M, Yang E, Zhu B, Walker DH, Zhang Y, Fang R.	Infect Immun	10.1128/iai.00468-24	2025
	Virulence potential of Rickettsia amblyommatis for spotted fever pathogenesis in mice.	Yen WY, Stern K, Mishra S, Helminiak L, Sanchez-Vicente S, Kim HK.	Pathog Dis	10.1093/femspd/ftab024	2021
Enzymology	Renal Involvement in Mediterranean Spotted Fever: Clinical and Histopathological Data.	Baltadzhiev I, Zaprianov Z, Baltadjiev A.	Med Princ Pract	10.1159/000516167	2021
Enzymology	Presence of Rickettsia conorii subsp. israelensis, the causative agent of Israeli spotted fever, in Sicily, Italy, ascertained in a retrospective study.	Giammanco GM, Vitale G, Mansueto S, Capra G, Caleca MP, Ammatuna P.	J Clin Microbiol	10.1128/jcm.43.12.6027-6031.2005	2005
	Role of reptiles and associated arthropods in the epidemiology of rickettsioses: A one health paradigm.	Mendoza-Roldan JA, Ravindran Santhakumari Manoj R, Latrofa MS, Iatta R, Annoscia G, Lovreglio P, Stufano A, Dantas-Torres F, Davoust B, Laidoudi Y, Mediannikov O, Otranto D.	PLoS Negl Trop Dis	10.1371/journal.pntd.0009090	2021
	Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection.	Astrup E, Ranheim T, Damas JK, Davi G, Santilli F, Jensenius M, Vitale G, Aukrust P, Olano JP, Otterdal K.	BMC Infect Dis	10.1186/1471-2334-14-70	2014
Metabolism	RNAi screen reveals host cell kinases specifically involved in Listeria monocytogenes spread from cell to cell.	Chong R, Squires R, Swiss R, Agaisse H.	PLoS One	10.1371/journal.pone.0023399	2011
Genetics	Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp.	El Karkouri K, Kowalczewska M, Armstrong N, Azza S, Fournier PE, Raoult D.	Front Microbiol	10.3389/fmicb.2017.01363	2017
	The absence of Toll-like receptor 4 signaling in C3H/HeJ mice predisposes them to overwhelming rickettsial infection and decreased protective Th1 responses.	Jordan JM, Woods ME, Olano J, Walker DH.	Infect Immun	10.1128/iai.00311-08	2008
	Tick-borne rickettsioses, neglected emerging diseases in rural Senegal.	Mediannikov O, Diatta G, Fenollar F, Sokhna C, Trape JF, Raoult D.	PLoS Negl Trop Dis	10.1371/journal.pntd.0000821	2010
	Differential interaction of dendritic cells with Rickettsia conorii: impact on host susceptibility to murine spotted fever rickettsiosis.	Fang R, Ismail N, Soong L, Popov VL, Whitworth T, Bouyer DH, Walker DH.	Infect Immun	10.1128/iai.00007-07	2007
	Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium.	Fang R, Ismail N, Walker DH.	Am J Pathol	10.1016/j.ajpath.2012.03.020	2012
Metabolism	Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection.	Feng HM, Whitworth T, Olano JP, Popov VL, Walker DH.	Infect Immun	10.1128/iai.72.4.2222-2228.2004	2004
Metabolism	Rickettsiae stimulate dendritic cells through toll-like receptor 4, leading to enhanced NK cell activation in vivo.	Jordan JM, Woods ME, Soong L, Walker DH.	J Infect Dis	10.1086/595833	2009
	Effect of antibody on the rickettsia-host cell interaction.	Feng HM, Whitworth T, Popov V, Walker DH.	Infect Immun	10.1128/iai.72.6.3524-3530.2004	2004
	CD4+ CD25+ Foxp3- T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted fever rickettsiosis.	Fang R, Ismail N, Shelite T, Walker DH.	Infect Immun	10.1128/iai.00349-09	2009
Metabolism	GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi.	Rauch J, Barton J, Kwiatkowski M, Wunderlich M, Steffen P, Moderzynski K, Papp S, Hohn K, Schwanke H, Witt S, Richardt U, Mehlhoop U, Schluter H, Pianka V, Fleischer B, Tappe D, Osterloh A.	PLoS One	10.1371/journal.pone.0253084	2021
	Tick-borne rickettsioses around the world: emerging diseases challenging old concepts.	Parola P, Paddock CD, Raoult D.	Clin Microbiol Rev	10.1128/cmr.18.4.719-756.2005	2005
Phylogeny	Taxonomic relationships among spotted fever group rickettsiae as revealed by antigenic analysis with monoclonal antibodies.	Xu W, Raoult D.	J Clin Microbiol	10.1128/jcm.36.4.887-896.1998	1998
	Genotypic evaluation of rickettsial isolates recovered from various species of ticks in Portugal.	Bacellar F, Regnery RL, Nuncio MS, Filipe AR.	Epidemiol Infect	10.1017/s095026880005202x	1995
	Human and tick spotted fever group Rickettsia isolates from Israel: a genotypic analysis.	Manor E, Ighbarieh J, Sarov B, Kassis I, Regnery R.	J Clin Microbiol	10.1128/jcm.30.10.2653-2656.1992	1992
Phylogeny	Proteinic and genomic identification of spotted fever group rickettsiae isolated in the former USSR.	Eremeeva ME, Balayeva NM, Ignatovich VF, Raoult D.	J Clin Microbiol	10.1128/jcm.31.10.2625-2633.1993	1993
Phylogeny	A novel alpha-Proteobacterium resides in the mitochondria of ovarian cells of the tick Ixodes ricinus.	Beninati T, Lo N, Sacchi L, Genchi C, Noda H, Bandi C.	Appl Environ Microbiol	10.1128/aem.70.5.2596-2602.2004	2004
Pathogenicity	In vitro susceptibilities of Bartonella henselae, B. quintana, B. elizabethae, Rickettsia rickettsii, R. conorii, R. akari, and R. prowazekii to macrolide antibiotics as determined by immunofluorescent-antibody analysis of infected Vero cell monolayers.	Ives TJ, Manzewitsch P, Regnery RL, Butts JD, Kebede M.	Antimicrob Agents Chemother	10.1128/aac.41.3.578	1997
	Critical role of cytotoxic T lymphocytes in immune clearance of rickettsial infection.	Walker DH, Olano JP, Feng HM.	Infect Immun	10.1128/iai.69.3.1841-1846.2001	2001
	The role of Rhipicephalus sanguineus ticks parasitizing dogs in the spread of tick-borne rickettsial pathogens in the city of Sevastopol.	Alieva EE, Bondarenko EI, Maliy KD, Shvalov AN, Verbenets EA, Gafarova MT	New Microbes New Infect	10.1016/j.nmni.2020.100704	2020
Phylogeny	Coxiella burnetii and Rickettsia conorii: Two zoonotic pathogens in peridomestic rodents and their ectoparasites in Nigeria.	Kamani J, Baneth G, Gutierrez R, Nachum-Biala Y, Mumcuoglu KY, Harrus S	Ticks Tick Borne Dis	10.1016/j.ttbdis.2017.10.004	2017
Metabolism	Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection.	Riley SP, Fish AI, Garza DA, Banajee KH, Harris EK, del Piero F, Martinez JJ	Infect Immun	10.1128/IAI.01205-15	2016
	Detection of natural killer T cells in mice infected with Rickettsia conorii.	La Manna MP, Torina A, Agnone A, Blanda V, Caracappa S, Alongi A, Di Marco V, Giudice E, Dieli F, Sireci G	Transbound Emerg Dis	10.1111/tbed.12143	2013
Enzymology	Mediterranean spotted fever in the Trakya region of Turkey.	Kuloglu F, Rolain JM, Akata F, Eroglu C, Celik AD, Parola P	Ticks Tick Borne Dis	10.1016/j.ttbdis.2012.10.030	2012
Pathogenicity	Some epidemiological features of the Mediterranean spotted fever re-emerging in Bulgaria.	Baltadzhiev IG, Popivanova NI	Folia Med (Plovdiv)	10.2478/v10153-011-0076-8	2012
Genetics	Detection of Rickettsia conorii strains in Portuguese dogs (Canis familiaris).	Alexandre N, Santos AS, Bacellar F, Boinas FJ, Nuncio MS, de Sousa R	Ticks Tick Borne Dis	10.1016/j.ttbdis.2011.03.001	2011
Pathogenicity	Characterization of rickettsial diseases in a hospital-based population in central Tunisia.	Kaabia N, Letaief A	Ann N Y Acad Sci	10.1111/j.1749-6632.2009.04521.x	2009
Enzymology	Incongruent effects of two isolates of Rickettsia conorii on the survival of Rhipicephalus sanguineus ticks.	Levin ML, Killmaster L, Zemtsova G, Grant D, Mumcuoglu KY, Eremeeva ME, Dasch GA	Exp Appl Acarol	10.1007/s10493-009-9268-9	2009
Pathogenicity	Host- and microbe-related risk factors for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients.	Sousa Rd, Franca A, Doria Nobrega S, Belo A, Amaro M, Abreu T, Pocas J, Proenca P, Vaz J, Torgal J, Bacellar F, Ismail N, Walker DH	J Infect Dis	10.1086/590211	2008
Pathogenicity	Prospective evaluation of rickettsioses in the Trakya (European) region of Turkey and atypic presentations of Rickettsia conorii.	Kuloglu F, Rolain JM, Aydoslu B, Akata F, Tugrul M, Raoult D	Ann N Y Acad Sci	10.1196/annals.1374.031	2006
Pathogenicity	Boutonneuse fever and climate variability.	de Sousa R, Luz T, Parreira P, Santos-Silva M, Bacellar F	Ann N Y Acad Sci	10.1196/annals.1374.029	2006
Pathogenicity	Characterization of a tandem repeat polymorphism in Rickettsia strains.	Vitorino L, de Sousa R, Bacellar F, Ze-Ze L	J Med Microbiol	10.1099/jmm.0.45956-0	2005
Phylogeny	Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conorii.	Zhu Y, Fournier PE, Eremeeva M, Raoult D	BMC Microbiol	10.1186/1471-2180-5-11	2005
Pathogenicity	[Epidemiologic features of Mediterranean spotted fever in Portugal].	Sousa Rd, Nobrega SD, Bacellar F, Torgal J	Acta Med Port		2003
Genetics	Use of highly variable intergenic spacer sequences for multispacer typing of Rickettsia conorii strains.	Fournier PE, Zhu Y, Ogata H, Raoult D	J Clin Microbiol	10.1128/JCM.42.12.5757-5766.2004	2004
Enzymology	First isolation of Rickettsia conorii from human blood in Croatia.	Sardelic S, Fournier PE, Punda Polic V, Bradaric N, Grgic D, Ivic I, Ledina D, Luksic B, Milas I, Raoult D	Croat Med J		2003
Pathogenicity	Report of eight cases of fatal and severe Mediterranean spotted fever in Portugal.	Amaro M, Bacellar F, Franca A	Ann N Y Acad Sci	10.1111/j.1749-6632.2003.tb07384.x	2003
Phylogeny	Short report: isolation and identification of two spotted fever group rickettsial strains from patients in Catalonia, Spain.	Cardenosa N, Roux V, Font B, Sanfeliu I, Raoult D, Segura F	Am J Trop Med Hyg	10.4269/ajtmh.2000.62.142	2000
Phylogeny	Phylogenetic analysis of spotted fever group rickettsiae by study of the outer surface protein rOmpA.	Fournier PE, Roux V, Raoult D	Int J Syst Bacteriol	10.1099/00207713-48-3-839	1998
	Role of T lymphocyte subsets in immunity to spotted fever group Rickettsiae.	Feng H, Popov VL, Yuoh G, Walker DH	J Immunol		1997
Genetics	Genotype characterization of the bacterium expressing the male-killing trait in the ladybird beetle Adalia bipunctata with specific rickettsial molecular tools.	Balayeva NM, Eremeeva ME, Tissot-Dupont H, Zakharov IA, Raoult D	Appl Environ Microbiol	10.1128/aem.61.4.1431-1437.1995	1995
Biotechnology	Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease.	Feng HM, Popov VL, Walker DH	Infect Immun	10.1128/iai.62.5.1952-1960.1994	1994
Transcriptome	Sequence analysis of the 190-kDa antigen-encoding gene of Rickettsia conorii (Malish 7 strain).	Crocquet-Valdes PA, Weiss K, Walker DH	Gene	10.1016/0378-1119(94)90740-4	1994
Enzymology	Cloning, sequencing, and expression of the gene coding for an antigenic 120-kilodalton protein of Rickettsia conorii.	Schuenke KW, Walker DH	Infect Immun	10.1128/iai.62.3.904-909.1994	1994
	Rickettsia conorii infection of C3H/HeN mice. A model of endothelial-target rickettsiosis.	Walker DH, Popov VL, Wen J, Feng HM	Lab Invest		1994
Pathogenicity	[The western immunoblotting technique in atypical situations of Rickettsia conorii infection. Presentation of 2 cases].	Herrero JI, Ruiz R, Walker DH	Enferm Infecc Microbiol Clin		1993
Pathogenicity	Antigenic diversity of Rickettsia conorii.	Walker DH, Liu QH, Yu XJ, Li H, Taylor C, Feng HM	Am J Trop Med Hyg	10.4269/ajtmh.1992.47.78	1992
Phylogeny	Barbash strain spotted fever group rickettsia is a strain of Rickettsia conorii and differs from Rickettsia sibirica.	Wang JG, Walker DD, Li H, Lenz B, Jerrells TR	Acta Virol		1987
Pathogenicity	Gamma interferon as a crucial host defense against Rickettsia conorii in vivo.	Li H, Jerrells TR, Spitalny GL, Walker DH	Infect Immun	10.1128/iai.55.5.1252-1255.1987	1987
	Cross-reactive lymphocyte responses and protective immunity against other spotted fever group rickettsiae in mice immunized with Rickettsia conorii.	Jerrells TR, Jarboe DL, Eisemann CS	Infect Immun	10.1128/iai.51.3.832-837.1986	1986
Phylogeny	Susceptibility of inbred mice to rickettsiae of the spotted fever group.	Eisemann CS, Nypaver MJ, Osterman JV	Infect Immun	10.1128/iai.43.1.143-148.1984	1984

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Rickettsia conorii (Malish 7, NIAID Malish 7, ATCC VR-613)

Name and taxonomic classification

Morphology

Culture and growth conditions

Physiology and metabolism

Isolation, sampling and environmental information

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

16S sequences

Genome-based predictions

Literature

Literature

References

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