Brevibacillus brevis (JCM 6285, NBRC 100599)

Name: Brevibacillus brevis (JCM 6285, NBRC 100599)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 165384

Type strain

Culture col. no. JCM 6285 NBRC 100599

NCBI tax ID(s) 358681 1393

Special Collections JCM

History S. Udaka 47.

Links

Brevibacillus brevis JCM 6285 is a mesophilic prokaryote that was isolated from Soil.

mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 64856

JCM 6285,NBRC 100599

@ref 20215

Last LPSN update 2025-12-16 10:09:39

Domain Bacillati

Phylum Bacillota

Class Bacilli

Order Caryophanales

Family Paenibacillaceae

Genus Brevibacillus

Species Brevibacillus brevis

Full scientific name Brevibacillus brevis (Migula 1900) Shida et al. 1996

Synonyms (1)

Bacillus brevis

BacDive ID	Other strains from **Brevibacillus brevis** (16)	Type strain
11402	B. brevis 27B, 604, DSM 30, ATCC 8246, CCM 2050, JCM ... (type strain)
11403	B. brevis DSM 5609, NRS 782
11404	B. brevis DSM 5667, NRS 1127
11405	B. brevis 7-2, DSM 6455, NRS 1434
100618	B. brevis STI05066(IMET),
134880	B. brevis CIP 102675
135841	B. brevis CIP 52.87, NRRL NRS-611, NRRL: NRS-611
137209	B. brevis CIP A32
144949	B. brevis CCUG 27247
160847	B. brevis JCM 10041
160848	B. brevis JCM 10042
160992	B. brevis JCM 10548
164085	B. brevis JCM 31516
164086	B. brevis JCM 31517
164087	B. brevis JCM 31518
165982	B. brevis JCM 8970

Morphology

Culture and growth conditions

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
67770	positive	growth	30	mesophilic

Physiology and metabolism

Spore formation

@ref	Spore formation	Confidence
125439		93.4

Isolation, sampling and environmental information

Isolation

67770

Sample typeSoil

Interaction and safety

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1016v1 assembly for Brevibacillus brevis NBRC 100599 NBRC 100599 (= 47)	complete	GCA_000010165	358681.3	643692011	358681	99.09

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
124043	Brevibacillus brevis gene for 16S rRNA, partial sequence, strain: NBRC 100599.	AB681205	1461		1393

GC content

@ref	GC-content (mol%)	Method
67770	47.2	high performance liquid chromatography (HPLC)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Brevibacillus brevis NBRC 100599
NCBI: GCA_000010165

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	93.40	no
125439	motility	BacteriaNetⓘ	yes	87.90	no
125439	gram_stain	BacteriaNetⓘ	variable	82.10	no
125439	oxygen_tolerance	BacteriaNetⓘ	aerobe	84.20	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Brevibacillus brevis NBRC 100599 NBRC 100599 (= 47)
NCBI: GCA_000010165.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	56.48	no
125438	anaerobic	anaerobicⓘ	no	96.82	no
125438	aerobic	aerobicⓘ	yes	77.84	no
125438	spore-forming	spore-formingⓘ	yes	88.72	no
125438	thermophilic	thermophileⓘ	no	93.18	yes
125438	flagellated	motile2+ⓘ	yes	86.48	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Isolation, Purification, and Characterisation of a Phage Tail-Like Bacteriocin from the Insect Pathogenic Bacterium Brevibacillus laterosporus.	Babar TK, Glare TR, Hampton JG, Hurst MRH, Narciso JO.	Biomolecules	10.3390/biom12081154	2022
	The structure of a polyketide synthase bimodule core.	Tittes YU, Herbst DA, Martin SFX, Munoz-Hernandez H, Jakob RP, Maier T.	Sci Adv	10.1126/sciadv.abo6918	2022
	Combination of fluorescent reagents with 2-(4-aminophenyl) benzothiazole and safranin O was useful for analysis of spore structure, indicating the diversity of Bacillales species spores.	Kuwana R, Ito K, Takamatsu H.	Front Microbiol	10.3389/fmicb.2025.1603957	2025
Genetics	Comparative Genomic Analysis of Brevibacillus brevis: Insights into Pan-Genome Diversity and Biocontrol Potential.	Yang W, Bao Q, Wang Y, Xiao L, Zeng Z, Zhou L, Yang H.	Microorganisms	10.3390/microorganisms13112456	2025
Phylogeny	Comprehensive genomic analysis of Brevibacillus brevis BF19 reveals its biocontrol potential against bitter gourd wilt.	Song L, Shen Y, Zhang H, Zhang H, Zhang Y, Wang M, Zhang M, Wang F, Zhou L, Wen C, Zhao Y.	BMC Microbiol	10.1186/s12866-024-03519-7	2024
Phylogeny	Biodegradation of plasticizers by novel strains of bacteria isolated from plastic waste near Juhu Beach, Mumbai, India.	Sharma K, Nayarisseri A, Singh SK.	Sci Rep	10.1038/s41598-024-81239-8	2024
Genetics	Brevibacillus brevis HNCS-1: a biocontrol bacterium against tea plant diseases.	Yang W, Yang H, Bao X, Hussain M, Bao Q, Zeng Z, Xiao C, Zhou L, Qin X.	Front Microbiol	10.3389/fmicb.2023.1198747	2023
	Mechanism of Brevibacillus brevis strain TR-4 against leaf disease of Photinia×fraseri Dress.	Ji C, Li YF, Yao Y, Zhu Z, Mao S.	PeerJ	10.7717/peerj.17568	2024
	Draft Genome Sequence of Brevibacillus brevis LABIM17, a Biotechnologically Important Antimicrobial-Producing Bacterium.	de Medeiros Chagas L, Teixeira GM, Mosela M, de Oliveira JP, Nicoletto MLA, Berte R, da Silva DV, Sanches DS, Brancher JD, Padua UP, de Oliveira AG.	Microbiol Resour Announc	10.1128/mra.00006-22	2022
Genetics	Investigation of the potential of Brevibacillus spp. for the biosynthesis of nonribosomally produced bioactive compounds by combination of genome mining with MALDI-TOF mass spectrometry.	Jahne J, Herfort S, Doellinger J, Lasch P, Tam LTT, Borriss R, Vater J.	Front Microbiol	10.3389/fmicb.2023.1286565	2023
Pathogenicity	Antibacterial Properties of Melanoidins Produced from Various Combinations of Maillard Reaction against Pathogenic Bacteria.	Kukuminato S, Koyama K, Koseki S.	Microbiol Spectr	10.1128/spectrum.01142-21	2021
	Antioxidant Activity and Other Characteristics of Lactic Acid Bacteria Isolated from Korean Traditional Sweet Potato Stalk Kimchi.	Park JM, Moon JW, Zhang BZ, An BK.	Foods	10.3390/foods13203261	2024
Genetics	Identification of Genome Sequences of Polyphosphate-Accumulating Organisms by Machine Learning.	Liu B, Nan J, Zu X, Zhang X, Xiao Q.	Front Cell Dev Biol	10.3389/fcell.2020.626221	2020
Genetics	Genome-Driven Discovery of Enzymes with Industrial Implications from the Genus Aneurinibacillus.	Kamli MR, Alzahrani NAY, Hajrah NH, Sabir JSM, Malik A.	Microorganisms	10.3390/microorganisms9030499	2021
	Enhancement of edeine production in Brevibacillus brevis X23 via in situ promoter engineering.	Liu Q, Zhang L, Wang Y, Zhang C, Liu T, Duan C, Bian X, Guo Z, Long Q, Tang Y, Du J, Liu A, Dai L, Li D, Chen W.	Microb Biotechnol	10.1111/1751-7915.13825	2022
	Draft Genome Sequence of Brevibacillus brevis DZQ7, a Plant Growth-Promoting Rhizobacterium with Broad-Spectrum Antimicrobial Activity.	Hou Q, Wang C, Hou X, Xia Z, Ye J, Liu K, Liu H, Wang J, Guo H, Yu X, Yang Y, Du B, Ding Y.	Genome Announc	10.1128/genomea.00831-15	2015
Transcriptome	Draft genome sequence of Brevibacillus brevis strain X23, a biocontrol agent against bacterial wilt.	Chen W, Wang Y, Li D, Li L, Xiao Q, Zhou Q.	J Bacteriol	10.1128/jb.01312-12	2012
	Spontaneously fermented Allium cepa L. as a source of lactic acid bacteria with probiotic potential.	Scieszka S, Piekarska-Radzik L, Klewicki R, Sojka M, Juskiewicz J, Fotschki B, Klewicka E, Grzelak-Blaszczyk K.	Sci Rep	10.1038/s41598-025-10037-7	2025
Metabolism	Purification and biochemical characterization of a highly thermostable bacteriocin isolated from Brevibacillus brevis strain GM100.	Ghadbane M, Harzallah D, Laribi AI, Jaouadi B, Belhadj H.	Biosci Biotechnol Biochem	10.1271/bbb.120681	2013
	Biocontrol properties from phyllospheric bacteria isolated from Solanum lycopersicum and Lactuca sativa and genome mining of antimicrobial gene clusters.	Munoz CY, Zhou L, Yi Y, Kuipers OP.	BMC Genomics	10.1186/s12864-022-08392-0	2022
	Draft Genome Sequence of Exopolysaccharide-Producing Thermophilic Bacterium Brevibacillus thermoruber Strain 423.	Yasar Yildiz S, Kambourova M, Arga KY, Toksoy Oner E.	Genome Announc	10.1128/genomea.00774-13	2013
	Heterologously expressed SacP23, a novel bacteriocin from Paenibacillus polymyxa #23, is active against methicillin resistant Staphylococcus aureus.	Khanh CM, Van Quyen D, Van TTH, Moore RJ.	R Soc Open Sci	10.1098/rsos.231119	2023
Metabolism	High-level intracellular expression of heterologous proteins in Brevibacillus choshinensis SP3 under the control of a xylose inducible promoter.	D'Urzo N, Martinelli M, Nenci C, Brettoni C, Telford JL, Maione D.	Microb Cell Fact	10.1186/1475-2859-12-12	2013
Genetics	Genome mining: Prediction of lipopeptides and polyketides from Bacillus and related Firmicutes.	Aleti G, Sessitsch A, Brader G.	Comput Struct Biotechnol J	10.1016/j.csbj.2015.03.003	2015
	The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies.	Pawlowski AC, Westman EL, Koteva K, Waglechner N, Wright GD.	ISME J	10.1038/s41396-017-0017-5	2018
Metabolism	Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase.	Atkinson GC, Hansen LH, Tenson T, Rasmussen A, Kirpekar F, Vester B.	Antimicrob Agents Chemother	10.1128/aac.00448-13	2013
Enzymology	Characterization of Bacteriocin like inhibitory substance produced by a new Strain Brevibacillus borstelensis AG1 Isolated from 'Marcha'.	Sharma N, Gupta A, Gautam N.	Braz J Microbiol	10.1590/s1517-83822014000300033	2014
	Isolation of Efficient Xylooligosaccharides-Fermenting Probiotic Lactic Acid Bacteria from Ethnic Pickled Bamboo Shoot Products.	Kanpiengjai A, Nuntikaew P, Wongsanittayarak J, Leangnim N, Khanongnuch C.	Biology (Basel)	10.3390/biology11050638	2022
	Adhesion and Anti-Adhesion Abilities of Potentially Probiotic Lactic Acid Bacteria and Biofilm Eradication of Honeybee (Apis mellifera L.) Pathogens.	Leska A, Nowak A, Czarnecka-Chrebelska KH.	Molecules	10.3390/molecules27248945	2022
	Diversity, distribution, and antagonistic activities of rhizobacteria of Panax notoginseng.	Fan ZY, Miao CP, Qiao XG, Zheng YK, Chen HH, Chen YW, Xu LH, Zhao LX, Guan HL.	J Ginseng Res	10.1016/j.jgr.2015.05.003	2016
	Metagenomic analyses reveal phylogenetic diversity of carboxypeptidase gene sequences in activated sludge of a wastewater treatment plant in Shanghai, China.	Jin H, Li B, Peng X, Chen L.	Ann Microbiol	10.1007/s13213-013-0704-z	2014
Phylogeny	Whole-genome phylogenies of the family Bacillaceae and expansion of the sigma factor gene family in the Bacillus cereus species-group.	Schmidt TR, Scott EJ, Dyer DW.	BMC Genomics	10.1186/1471-2164-12-430	2011
	A diverse intrinsic antibiotic resistome from a cave bacterium.	Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD.	Nat Commun	10.1038/ncomms13803	2016
Enzymology	Isolation and Characterization of Lactobacillus brevis Phages.	Feyereisen M, Mahony J, Lugli GA, Ventura M, Neve H, Franz CMAP, Noben JP, O'Sullivan T, Sinderen DV.	Viruses	10.3390/v11050393	2019
	A conjugative 38 kB plasmid is present in multiple subspecies of Xylella fastidiosa.	Rogers EE, Stenger DC.	PLoS One	10.1371/journal.pone.0052131	2012
Genetics	Mining of Microbial Genomes for the Novel Sources of Nitrilases.	Sharma N, Thakur N, Raj T, Savitri, Bhalla TC.	Biomed Res Int	10.1155/2017/7039245	2017
	Simulation of Enhanced Growth of Marine Group II Euryarchaeota From the Deep Chlorophyll Maximum of the Western Pacific Ocean: Implication for Upwelling Impact on Microbial Functions in the Photic Zone.	Dai J, Ye Q, Wu Y, Zhang M, Zhang J.	Front Microbiol	10.3389/fmicb.2020.571199	2020
	Dissemination of 6S RNA among bacteria.	Wehner S, Damm K, Hartmann RK, Marz M.	RNA Biol	10.4161/rna.29894	2014
	Functional Comparison of Bacteria from the Human Gut and Closely Related Non-Gut Bacteria Reveals the Importance of Conjugation and a Paucity of Motility and Chemotaxis Functions in the Gut Environment.	Dobrijevic D, Abraham AL, Jamet A, Maguin E, van de Guchte M.	PLoS One	10.1371/journal.pone.0159030	2016
Metabolism	Emergence of cytochrome bc complexes in the context of photosynthesis.	Dibrova DV, Shalaeva DN, Galperin MY, Mulkidjanian AY.	Physiol Plant	10.1111/ppl.12586	2017
	GABA-Producing Natural Dairy Isolate From Artisanal Zlatar Cheese Attenuates Gut Inflammation and Strengthens Gut Epithelial Barrier in vitro.	Sokovic Bajic S, Djokic J, Dinic M, Veljovic K, Golic N, Mihajlovic S, Tolinacki M.	Front Microbiol	10.3389/fmicb.2019.00527	2019
	Alternative strategies of nutrient acquisition and energy conservation map to the biogeography of marine ammonia-oxidizing archaea.	Qin W, Zheng Y, Zhao F, Wang Y, Urakawa H, Martens-Habbena W, Liu H, Huang X, Zhang X, Nakagawa T, Mende DR, Bollmann A, Wang B, Zhang Y, Amin SA, Nielsen JL, Mori K, Takahashi R, Virginia Armbrust E, Winkler MH, DeLong EF, Li M, Lee PH, Zhou J, Zhang C, Zhang T, Stahl DA, Ingalls AE.	ISME J	10.1038/s41396-020-0710-7	2020
Metabolism	Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaea.	Makarova KS, Koonin EV.	Biol Direct	10.1186/1745-6150-5-33	2010
Metabolism	Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis.	Boll B, Taubitz T, Heide L.	J Biol Chem	10.1074/jbc.m111.288092	2011
Genetics	Comparative genome analysis of the Lactobacillus brevis species.	Feyereisen M, Mahony J, Kelleher P, Roberts RJ, O'Sullivan T, Geertman JA, van Sinderen D.	BMC Genomics	10.1186/s12864-019-5783-1	2019
Metabolism	Extent of the annual Gulf of Mexico hypoxic zone influences microbial community structure.	Campbell LG, Thrash JC, Rabalais NN, Mason OU.	PLoS One	10.1371/journal.pone.0209055	2019
Metabolism	Characterization of 5-chloro-5-deoxy-D-ribose 1-dehydrogenase in chloroethylmalonyl coenzyme A biosynthesis: substrate and reaction profiling.	Kale AJ, McGlinchey RP, Moore BS.	J Biol Chem	10.1074/jbc.m110.153833	2010
Metabolism	Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills.	Elshahawi SI, Trindade-Silva AE, Hanora A, Han AW, Flores MS, Vizzoni V, Schrago CG, Soares CA, Concepcion GP, Distel DL, Schmidt EW, Haygood MG.	Proc Natl Acad Sci U S A	10.1073/pnas.1213892110	2013
Phylogeny	Acidification Enhances Hybrid N₂O Production Associated with Aquatic Ammonia-Oxidizing Microorganisms.	Frame CH, Lau E, Nolan EJ, Goepfert TJ, Lehmann MF.	Front Microbiol	10.3389/fmicb.2016.02104	2016
Enzymology	Structural and mechanistic characterization of L-histidinol phosphate phosphatase from the polymerase and histidinol phosphatase family of proteins.	Ghodge SV, Fedorov AA, Fedorov EV, Hillerich B, Seidel R, Almo SC, Raushel FM.	Biochemistry	10.1021/bi301496p	2013
	Lengths of Orthologous Prokaryotic Proteins Are Affected by Evolutionary Factors.	Tatarinova T, Salih B, Dien Bard J, Cohen I, Bolshoy A.	Biomed Res Int	10.1155/2015/786861	2015
Proteome	Structural insights into inhibition of Bacillus anthracis sporulation by a novel class of non-heme globin sensor domains.	Stranzl GR, Santelli E, Bankston LA, La Clair C, Bobkov A, Schwarzenbacher R, Godzik A, Perego M, Grynberg M, Liddington RC.	J Biol Chem	10.1074/jbc.m110.207126	2011
	A super-family of transcriptional activators regulates bacteriophage packaging and lysis in Gram-positive bacteria.	Quiles-Puchalt N, Tormo-Mas MA, Campoy S, Toledo-Arana A, Monedero V, Lasa I, Novick RP, Christie GE, Penades JR.	Nucleic Acids Res	10.1093/nar/gkt508	2013
	Cell surface display of chimeric glycoproteins via the S-layer of Paenibacillus alvei.	Zarschler K, Janesch B, Kainz B, Ristl R, Messner P, Schaffer C.	Carbohydr Res	10.1016/j.carres.2010.04.010	2010
Metabolism	Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species.	Zhao X, Kuipers OP.	BMC Genomics	10.1186/s12864-016-3224-y	2016
Enzymology	Genome-based analysis of non-ribosomal peptide synthetase and type-I polyketide synthase gene clusters in all type strains of the genus Herbidospora.	Komaki H, Ichikawa N, Oguchi A, Hamada M, Tamura T, Fujita N.	BMC Res Notes	10.1186/s13104-015-1526-9	2015
Metabolism	Comparative genome analysis of central nitrogen metabolism and its control by GlnR in the class Bacilli.	Groot Kormelink T, Koenders E, Hagemeijer Y, Overmars L, Siezen RJ, de Vos WM, Francke C.	BMC Genomics	10.1186/1471-2164-13-191	2012
	Methods of combinatorial optimization to reveal factors affecting gene length.	Bolshoy A, Tatarinova T.	Bioinform Biol Insights	10.4137/bbi.s10525	2012
Enzymology	Redundancy and modularity in membrane-associated dissimilatory nitrate reduction in Bacillus.	Heylen K, Keltjens J.	Front Microbiol	10.3389/fmicb.2012.00371	2012
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
Genetics	Draft Genome Sequence of Biocontrol Bacterium Brevibacillus brevis Strain FJAT-0809-GLX.	Che J, Liu B, Lin Y, Tang W, Tang J	Genome Announc	10.1128/genomeA.00160-13	2013
Genetics	Non-contiguous finished genome sequence and description of Paenibacillus gorillae sp. nov.	Keita MB, Padhmananabhan R, Caputo A, Robert C, Delaporte E, Raoult D, Fournier PE, Bittar F.	Stand Genomic Sci	10.4056/sigs.5189179	2014
Genetics	Non-contiguous finished genome sequence and description of Gorillibacterium massiliense gen. nov, sp. nov., a new member of the family Paenibacillaceae.	Keita MB, Padhmanabhan R, Caputo A, Robert C, Delaporte E, Raoult D, Fournier PE, Bittar F.	Stand Genomic Sci	10.4056/sigs.5199182	2014

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Brevibacillus brevis (JCM 6285, NBRC 100599)

Name and taxonomic classification

Morphology

Culture and growth conditions

Culture temp

Physiology and metabolism

Spore formation

Isolation, sampling and environmental information

Isolation

Interaction and safety

Sequence information

Genome sequences

Genome browser: GCA_000010165

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

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