Name: Streptomyces niveus MA-319
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 16449

Type strain:

Species: Streptomyces niveus

Strain Designation: MA-319

Culture col. no.: DSM 40292, ATCC 23965, CBS 491.62, CBS 948.68, CGMCC AS 4.1380, ETH 31568, IFO 12917, ISP 5292, JCM 4252, NBRC 12917, NCBI 11891, NRRL 2449, RIA 1200, RIA 700, BCRC 11559, CGMCC 4.1380, JCM 4670, LMG 19392, LMG 8580, MTCC 1821, NCIMB 11891, NCIMB 9805

Strain history: KCC S-0252 <-- NRRL 2449 <-- Merck Sharp & Dohme Res. Labs.; MA-319.

NCBI tax ID(s): 1352941 (strain), 193462 (species)

SI-ID 389293

LMG 19392, ATCC 23965, CCRC 11559, DSM 40292, IFO 12917, JCM 4252, JCM 4670, LMG 8580, NCIMB 11891, NRRL 2449, NRRL B-2449, NCIB 11891, NCIMB9805, CBS 948.68, CBS 491.62, NBRC 12917, AS 4.1380, BCRC 11559, CGMCC 4.1380

Other strains from Streptomyces niveus

S. niveus DSM 40088, AS 4.1370, ATCC 19793, ... (type strain)
S. niveus C7655, DSM 41786
S. niveus C765, DSM 41787
S. niveus C7654, DSM 41788, AS 4.1832, JCM ...
S. niveus ST028267(HKI), FSU-4039, Schmiedeknecht ...
S. niveus SF004039(FSU),

Section

Streptomyces niveus MA-319 is a spore-forming, mesophilic bacterium that was isolated from soil.

spore-forming
mesophilic
16S sequence
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Actinomycetota*
	Class	*Actinomycetes*
	Order	*Kitasatosporales*
	Family	*Streptomycetaceae*
	Genus	*Streptomyces*
	Species	**Streptomyces niveus**
	Full Scientific Name (LPSN)	Streptomyces niveus Smith et al. 1956 (Approved Lists 1980)

	Synonym	Streptomyces spheroides
	Synonym	Streptomyces laceyi

Information on morphological and physiological properties Morphology

[Ref.: #69480]	Gram stain	positive Confidence in %100

[Ref.: #69480]	Motility	no Confidence in %91.753

Multimedia content

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Caption:

Medium 65 28°C

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Intellectual property rights:

Information on culture and growth conditions Culture and growth conditions

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Culture medium

GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)

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Culture medium growth

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Culture medium link

Medium recipe at MediaDive

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Culture medium composition

expand / minimize

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Culture medium

ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)

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Culture medium growth

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Culture medium link

Medium recipe provided by DSMZ

	Temperatures	Kind of temperature		Temperature
[Ref.: #9437]			growth	28 °C
[Ref.: #67770]			growth	28 °C

[Ref.: #9437]	Temperature range	mesophilic
[Ref.: #67770]	Temperature range	mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #69481]	Ability of spore formation	yes Confidence in %100
[Ref.: #69480]	Ability of spore formation	yes Confidence in %100

[Ref.: #9437]	Name of produced compound	novobiocin
[Ref.: #9437]	Name of produced compound	desmethylnovobiocin
[Ref.: #9437]	Name of produced compound	3 amino-4,7-dihydroxycoumarin hydrochloride

	Metabolite production	Metabolite	Production
[Ref.: #67770]		novobiocin ChEBI	yes

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #9437]	Sample type/isolated from	soil
[Ref.: #9437]	Country	USA
[Ref.: #9437]	Country ISO 3 Code	USA
[Ref.: #9437]	Continent	North America

[Ref.: #67770]	Sample type/isolated from	Soil, an old sod pasture
[Ref.: #67770]	Geographic location (country and/or sea, region)	VT
[Ref.: #67770]	Country	USA
[Ref.: #67770]	Country ISO 3 Code	USA
[Ref.: #67770]	Continent	North America
* marker position based on {}

Isolation sources categories

#Environmental

#Terrestrial

#Soil

What are isolation sources categories?

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

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Biosafety level

Risk group (German classification)
According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #9437]	Streptomyces caeruleus strain NRRL 2449 16S ribosomal RNA gene, partial sequence	EF178698	1604	ENA	193462 tax ID
[Ref.: #20218]	Streptomyces caeruleus strain NRRL 2449 16S ribosomal RNA gene, partial sequence	DQ445788	1572	ENA	193462 tax ID	*
[Ref.: #20218]	Actinoalloteichus cyanogriseus gene for 16S rRNA, partial sequence, strain: NBRC 12917	AB184854	1472	ENA	65497 tax ID	*

Genome sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #67770]	Streptomyces niveus NRRL 2449	GCA_001723075	scaffold	GenBank	193462 tax ID
[Ref.: #66792]	Streptomyces niveus NCIMB 11891	1352941.8	plasmid	PATRIC	1352941 tax ID	*
[Ref.: #66792]	Streptomyces niveus NCIMB 11891	1352941.11	plasmid	PATRIC	1352941 tax ID	*
[Ref.: #66792]	Streptomyces niveus NCIMB 11891	1352941.9	plasmid	PATRIC	1352941 tax ID	*
[Ref.: #66792]	Streptomyces niveus NCIMB 11891	1352941.4	complete	PATRIC	1352941 tax ID	*
[Ref.: #66792]	Streptomyces niveus NCIMB 11891	1352941.10	plasmid	PATRIC	1352941 tax ID	*

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GC-content

70.7 mol%

genome sequence analysis

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from GenomeNet Sporulation v. 1 based on: Streptomyces niveus NCIMB 11891 NCIMB 11891 NCBI: GCA_000497425.1
[Ref.: #69481]	spore-forming	yes	100	no

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Streptomyces niveus NCIMB 11891 PATRIC: 1352941.4
[Ref.: #69480]	motile	no	94.224	no
[Ref.: #69480]	gram-positive	yes	86.667	no
[Ref.: #69480]	anaerobic	no	99.221	no
[Ref.: #69480]	halophile	no	92.922	no
[Ref.: #69480]	spore-forming	yes	94.827	no
[Ref.: #69480]	thermophile	no	98.302	yes
[Ref.: #69480]	glucose-util	yes	89.545	no
[Ref.: #69480]	flagellated	no	97.464	no
[Ref.: #69480]	aerobic	yes	93.716	no
[Ref.: #69480]	glucose-ferment	no	87.858	no

Availability in culture collections External links

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Culture collection no.

DSM 40292, ATCC 23965, CBS 491.62, CBS 948.68, CGMCC AS 4.1380, ETH 31568, IFO 12917, ISP 5292, JCM 4252, NBRC 12917, NCBI 11891, NRRL 2449, RIA 1200, RIA 700, BCRC 11559, CGMCC 4.1380, JCM 4670, LMG 19392, LMG 8580, MTCC 1821, NCIMB 11891, NCIMB 9805

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SI-ID 389293

Literature:

Topic	Title	Authors	Journal	DOI	Year
Metabolism	DNA affinity capturing identifies new regulators of the heterologously expressed novobiocin gene cluster in Streptomyces coelicolor M512.	Bekiesch P, Franz-Wachtel M, Kulik A, Brocker M, Forchhammer K, Gust B, Apel AK	Appl Microbiol Biotechnol	10.1007/s00253-016-7306-1	2016	*
Genetics	Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the Aminocoumarin Antibiotic Novobiocin.	Flinspach K, Ruckert C, Kalinowski J, Heide L, Apel AK	Genome Announc	10.1128/genomeA.01146-13	2014	*
Metabolism	Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation.	Eustaquio AS, Luft T, Wang ZX, Gust B, Chater KF, Li SM, Heide L	Arch Microbiol	10.1007/s00203-003-0555-2	2003	*
Enzymology	Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891.	Steffensky M, Li SM, Heide L	J Biol Chem	10.1074/jbc.M003066200	2000	*
Phylogeny	The search for synonyms among streptomycetes by using SDS-PAGE of whole-cell proteins. Emendation of the species Streptomyces aurantiacus, Streptomyces cacaoi subsp. cacaoi, Streptomyces caeruleus and Streptomyces violaceus.	Lanoot B, Vancanneyt M, Cleenwerck I, Wang L, Li W, Liu Z, Swings J	Int J Syst Evol Microbiol	10.1099/00207713-52-3-823	2002	*

References

#9437

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40292

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#20218

Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#67770 Japan Collection of Microorganism (JCM) ; Curators of the JCM;

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#69481

Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch: Predictions based on the model GenomeNet Sporulation v. 1 . ( DOI 10.21203/rs.3.rs-2527258/v1 )

#85486

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID389293.1 )

* These data were automatically processed and therefore are not curated

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Streptomyces niveus NCIMB 11891 NCIMB 11891

Streptomyces niveus NCIMB 11891

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