Streptomyces niveus (DSM 40292, ATCC 23965, CBS 491.62)

Name: Streptomyces niveus (DSM 40292, ATCC 23965, CBS 491.62)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 16449

Type strain

Strain Designation MA-319

Culture col. no. DSM 40292 ATCC 23965 CBS 491.62 CBS 948.68 CGMCC AS 4.1380 18 more

NCBI tax ID(s) 1352941 193462

Special Collections DSMZ JCM

History <- E.B. Shirling, ISP <- H.B. Woodruff, Merck, Sharp and Dohme, MA-319 KCC S-0252 <-- NRRL 2449 <-- Merck Sharp & Dohme Res. Labs.; MA-319.

Links

Streptomyces niveus MA-319 is a bacterium that was isolated from soil.

genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 389293

LMG 19392,ATCC 23965,CCRC 11559,DSM 40292,IFO 12917,JCM 4252,JCM 4670,LMG 8580,NCIMB 11891,NRRL 2449,NRRL B-2449,NCIB 11891,NCIMB9805,CBS 948.68,CBS 491.62,NBRC 12917,AS 4.1380,BCRC 11559,CGMCC 4.1380

@ref 20215

Last LPSN update 2026-02-09 11:21:58

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Kitasatosporales

Family Streptomycetaceae

Genus Streptomyces

Species Streptomyces niveus

Full scientific name Streptomyces niveus Smith et al. 1956 (Approved Lists 1980)

Synonyms (2)

Streptomyces laceyi
Streptomyces spheroides

BacDive ID	Other strains from **Streptomyces niveus** (6)	Type strain
16448	S. niveus DSM 40088, AS 4.1370, ATCC 19793, CBS 545.68, ... (type strain)
16450	S. niveus C7655, DSM 41786
16451	S. niveus C765, DSM 41787
16452	S. niveus C7654, DSM 41788, AS 4.1832, JCM 12606, NBRC ...
127963	S. niveus ST028267(HKI), FSU-4039, Schmiedeknecht 491,
127964	S. niveus SF004039(FSU),

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	positive	98.9

Multimedia

@ref:	9437
multimedia content:	DSM_40292.jpg
multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40292.jpg
caption:	Medium 65 28°C
intellectual property rights:	© Leibniz-Institut DSMZ
manual_annotation:	1

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
9437	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
9437	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)		Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
9437	positive	growth	28
67770	positive	growth	28

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125438	aerobe	91.304
125439	obligate aerobe	93

Spore formation

@ref	Spore formation	Confidence
125439		94.3

Compound production

@ref	Compound
9437	novobiocin
9437	desmethylnovobiocin
9437	3 amino-4,7-dihydroxycoumarin hydrochloride

Metabolite production

@ref	Chebi-ID	Metabolite	Production
67770	28368 ChEBI	novobiocin

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Soil

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
9437	soil		USA	USA	North America
67770	Soil, an old sod pasture	VT	USA	USA	North America

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
9437	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	IMG accession	NCBI tax ID	Score	BV-BRC accession
66792	S.niveus_v1 assembly for Streptomyces niveus NCIMB 11891	chromosome	GCA_000497425	2602041572	1352941	25.3
67770	ASM172307v1 assembly for Streptomyces niveus NRRL 2449	scaffold	GCA_001723075	2811995187	193462		193462.4

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Actinoalloteichus caeruleus gene for 16S rRNA, partial sequence, strain: NBRC 12917	AB184854	1472	65497
20218	Streptomyces caeruleus strain NRRL 2449 16S ribosomal RNA gene, partial sequence	DQ445788	1572	193462
9437	Streptomyces caeruleus strain NRRL 2449 16S ribosomal RNA gene, partial sequence	EF178698	1604	193462

GC content

@ref	GC-content (mol%)	Method
67770	70.7	genome sequence analysis

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Streptomyces niveus NCIMB 11891
PATRIC: 1352941.4

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	94.30	no
125439	motility	BacteriaNetⓘ	no	85.40	no
125439	gram_stain	BacteriaNetⓘ	positive	98.90	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	93.00	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptomyces niveus NCIMB 11891
PATRIC: 1352941.4

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	89.58	no
125438	anaerobic	anaerobicⓘ	no	97.41	no
125438	spore-forming	spore-formingⓘ	yes	89.55	no
125438	aerobic	aerobicⓘ	yes	91.30	no
125438	thermophilic	thermophileⓘ	no	95.00	no
125438	flagellated	motile2+ⓘ	no	87.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Genetic approaches to improve clorobiocin production in Streptomyces roseochromogenes NRRL 3504.	Melnyk S, Stepanyshyn A, Yushchuk O, Mandler M, Ostash I, Koshla O, Fedorenko V, Kahne D, Ostash B.	Appl Microbiol Biotechnol	10.1007/s00253-022-11814-4	2022
	Novel endophytic actinomycetes species Streptomyces panacea of Panax sokpayensis produce antimicrobial compounds against multidrug resistant Staphylococcus aureus.	Rai S, Singh LS, Liriina K, Jeyaram K, Parija T, Sahoo D.	Sci Rep	10.1038/s41598-025-05333-1	2025
Genetics	AI-based automated construction of high-precision Geobacillus thermoglucosidasius enzyme constraint model.	Zhang M, Shi H, Wang X, Zhu Y, Li Z, Tu L, Zheng Y, Xia M, Wang W, Wang M.	Metab Eng	10.1016/j.ymben.2024.10.006	2024
Biotechnology	Novel endophytic actinomycetes species Streptomyces panacea of Panax sokpayensis produce antimicrobial compounds against multidrug resistant Staphylococcus aureus	Rai S, Singh L, Liriina K, Jeyaram K, Parija T, Sahoo D.	Sci Rep		2025
	Characterization of germinant receptors of P. thermoglucosidasius NCIMB 11955.	Salvador M, Lau MSH, Minton NP, Condon S, Gayan E.	Curr Res Microb Sci	10.1016/j.crmicr.2025.100485	2025
Phylogeny	SYN-View: A Phylogeny-Based Synteny Exploration Tool for the Identification of Gene Clusters Linked to Antibiotic Resistance.	Stahlecker J, Mingyar E, Ziemert N, Mungan MD.	Molecules	10.3390/molecules26010144	2020
Metabolism	Genome-scale metabolic modeling of P. thermoglucosidasius NCIMB 11955 reveals metabolic bottlenecks in anaerobic metabolism.	Mol V, Bennett M, Sanchez BJ, Lisowska BK, Herrgard MJ, Nielsen AT, Leak DJ, Sonnenschein N.	Metab Eng	10.1016/j.ymben.2021.03.002	2021
Metabolism	Complete genome sequence of the deep South China Sea-derived Streptomyces niveus SCSIO 3406, the producer of cytotoxic and antibacterial marfuraquinocins.	Zhu Q, Cheng W, Song Y, He Q, Ju J, Li Q.	PLoS One	10.1371/journal.pone.0248404	2021
	Synthetic pathways to create asymmetric center at C1 position of 1-substituted-tetrahydro-beta-carbolines - a review.	Asif MMA, Lisa SR, Qais N.	RSC Adv	10.1039/d4ra05961a	2024
	Genome-scale metabolic modelling of extremophiles and its applications in astrobiological environments.	Noirungsee N, Changkhong S, Phinyo K, Suwannajak C, Tanakul N, Inwongwan S.	Environ Microbiol Rep	10.1111/1758-2229.13231	2024
	Complete Genome Sequence of Geobacillus thermoglucosidasius NCIMB 11955, the Progenitor of a Bioethanol Production Strain.	Sheng L, Zhang Y, Minton NP.	Genome Announc	10.1128/genomea.01065-16	2016
Genetics	Genome-scale reconstruction and metabolic modelling of the fast-growing thermophile Geobacillus sp. LC300.	Ljungqvist E, Gustavsson M.	Metab Eng Commun	10.1016/j.mec.2022.e00212	2022
Genetics	A Genome-Scale Metabolic Model of 2,3-Butanediol Production by Thermophilic Bacteria Geobacillus icigianus.	Kulyashov M, Peltek SE, Akberdin IR.	Microorganisms	10.3390/microorganisms8071002	2020
	Metabolic engineering for the production of acetoin and 2,3-butanediol at elevated temperature in Parageobacillus thermoglucosidasius NCIMB 11955.	Sheng L, Madika A, Lau MSH, Zhang Y, Minton NP.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1191079	2023
Enzymology	A single module type I polyketide synthase directs de novo macrolactone biogenesis during galbonolide biosynthesis in Streptomyces galbus.	Kim HJ, Karki S, Kwon SY, Park SH, Nahm BH, Kim YK, Kwon HJ.	J Biol Chem	10.1074/jbc.m114.602334	2014
	PathwayBooster: a tool to support the curation of metabolic pathways.	Liberal R, Lisowska BK, Leak DJ, Pinney JW.	BMC Bioinformatics	10.1186/s12859-014-0447-2	2015
Transcriptome	Recently published Streptomyces genome sequences.	Harrison J, Studholme DJ.	Microb Biotechnol	10.1111/1751-7915.12143	2014
	Exploring novel bacterial terpene synthases.	Reddy GK, Leferink NGH, Umemura M, Ahmed ST, Breitling R, Scrutton NS, Takano E.	PLoS One	10.1371/journal.pone.0232220	2020
Enzymology	Structure of an acetylating aldehyde dehydrogenase from the thermophilic ethanologen Geobacillus thermoglucosidasius.	Extance J, Danson MJ, Crennell SJ.	Protein Sci	10.1002/pro.3027	2016
	Development of an efficient technique for gene deletion and allelic exchange in Geobacillus spp.	Bacon LF, Hamley-Bennett C, Danson MJ, Leak DJ.	Microb Cell Fact	10.1186/s12934-017-0670-4	2017
Enzymology	Sequence-Based In-silico Discovery, Characterisation, and Biocatalytic Application of a Set of Imine Reductases.	Velikogne S, Resch V, Dertnig C, Schrittwieser JH, Kroutil W.	ChemCatChem	10.1002/cctc.201800607	2018
	Engineering Geobacillus thermoglucosidasius for direct utilisation of holocellulose from wheat straw.	Bashir Z, Sheng L, Anil A, Lali A, Minton NP, Zhang Y.	Biotechnol Biofuels	10.1186/s13068-019-1540-6	2019
Metabolism	Characterization of DNA Binding Sites of RokB, a ROK-Family Regulator from Streptomyces coelicolor Reveals the RokB Regulon.	Bekiesch P, Forchhammer K, Apel AK.	PLoS One	10.1371/journal.pone.0153249	2016
Metabolism	Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis.	Boll B, Taubitz T, Heide L.	J Biol Chem	10.1074/jbc.m111.288092	2011
Genetics	Development and implementation of rapid metabolic engineering tools for chemical and fuel production in Geobacillus thermoglucosidasius NCIMB 11955.	Sheng L, Kovacs K, Winzer K, Zhang Y, Minton NP.	Biotechnol Biofuels	10.1186/s13068-016-0692-x	2017
	Analysis of anoxybacillus genomes from the aspects of lifestyle adaptations, prophage diversity, and carbohydrate metabolism.	Goh KM, Gan HM, Chan KG, Chan GF, Shahar S, Chong CS, Kahar UM, Chai KP.	PLoS One	10.1371/journal.pone.0090549	2014
Metabolism	Genetic tool development underpins recent advances in thermophilic whole-cell biocatalysts.	Taylor MP, van Zyl L, Tuffin IM, Leak DJ, Cowan DA.	Microb Biotechnol	10.1111/j.1751-7915.2010.00246.x	2011
Metabolism	DNA affinity capturing identifies new regulators of the heterologously expressed novobiocin gene cluster in Streptomyces coelicolor M512.	Bekiesch P, Franz-Wachtel M, Kulik A, Brocker M, Forchhammer K, Gust B, Apel AK	Appl Microbiol Biotechnol	10.1007/s00253-016-7306-1	2016
Genetics	Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the Aminocoumarin Antibiotic Novobiocin.	Flinspach K, Ruckert C, Kalinowski J, Heide L, Apel AK	Genome Announc	10.1128/genomeA.01146-13	2014
Metabolism	Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation.	Eustaquio AS, Luft T, Wang ZX, Gust B, Chater KF, Li SM, Heide L	Arch Microbiol	10.1007/s00203-003-0555-2	2003
Enzymology	Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891.	Steffensky M, Li SM, Heide L	J Biol Chem	10.1074/jbc.M003066200	2000
Phylogeny	The search for synonyms among streptomycetes by using SDS-PAGE of whole-cell proteins. Emendation of the species Streptomyces aurantiacus, Streptomyces cacaoi subsp. cacaoi, Streptomyces caeruleus and Streptomyces violaceus.	Lanoot B, Vancanneyt M, Cleenwerck I, Wang L, Li W, Liu Z, Swings J	Int J Syst Evol Microbiol	10.1099/00207713-52-3-823	2002

References

#9437	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40292
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptomyces niveus (DSM 40292, ATCC 23965, CBS 491.62)

Name and taxonomic classification

Morphology

Cell morphology

Multimedia

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Compound production

Metabolite production

Isolation, sampling and environmental information

Isolation source categories

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_000497425

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

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