Lactobacillus crispatus JCM 2009 is a bacterium that was isolated from Urine.
16S sequence Bacteria| @ref 20215 |
Last LPSN update
2026-02-09 11:39:28 |
| Domain Bacteria |
| Phylum Bacillota |
| Class Bacilli |
| Order Lactobacillales |
| Family Lactobacillaceae |
| Genus Lactobacillus |
| Species Lactobacillus crispatus |
| Full scientific name Lactobacillus crispatus (Brygoo and Aladame 1953) Moore and Holdeman 1970 (Approved Lists 1980) |
| Synonyms (1) |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 124043 | Lactobacillus crispatus gene for 16S rRNA, partial sequence, strain: JCM 2009. | AB289068 | 689 |  | 47770 |  |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Transcriptome | Cervicovaginal microbiome alters transcriptomic and chromatin accessibility signatures across cervicovaginal epithelial barriers. | Anton L, Cristancho AG, Ferguson B, Ravel J, Elovitz MA. | Microbiome | 10.1186/s40168-025-02223-6 | 2025 | |
| Phylogeny | The role of cervical microbiome in cervical incompetence: insights from 16 S rRNA metagenomic sequencing. | Jingwen J, Jingran F, Liye M, Yu H, Yancen M, Jingya Z. | BMC Microbiol | 10.1186/s12866-025-04203-0 | 2025 | |
| In vitro antimicrobial activity of Bixa orellana L . Leaves extract against anaerobic bacteria associated to bacterial vaginosis and Lactobacillus spp. | Marcas J, Romero L, Tipiani O, Loyola S, Tamariz J. | Rev Peru Med Exp Salud Publica | 10.17843/rpmesp.2022.394.11978 | 2022 | | |
| Pathogenicity | Intrauterine colonization with Gardnerella vaginalis and Mobiluncus mulieris induces maternal inflammation but not preterm birth in a mouse model. | Joseph A, Lewis EL, Ferguson B, Guan Y, Anton L, Elovitz MA. | Am J Reprod Immunol | 10.1111/aji.13749 | 2023 | |
| Extracellular vesicles from vaginal Gardnerella vaginalis and Mobiluncus mulieris contain distinct proteomic cargo and induce inflammatory pathways. | Joseph A, Anton L, Guan Y, Ferguson B, Mirro I, Meng N, France M, Ravel J, Elovitz MA. | NPJ Biofilms Microbiomes | 10.1038/s41522-024-00502-y | 2024 | | |
| Pathogenicity | Gardnerella vaginalis induces matrix metalloproteinases in the cervicovaginal epithelium through TLR-2 activation. | Gerson KD, Anton L, Ferguson B, Ravel J, Burris HH, Elovitz MA. | J Reprod Immunol | 10.1016/j.jri.2022.103648 | 2022 | |
| Pathogenicity | Gardnerella vaginalis alters cervicovaginal epithelial cell function through microbe-specific immune responses. | Anton L, Ferguson B, Friedman ES, Gerson KD, Brown AG, Elovitz MA. | Microbiome | 10.1186/s40168-022-01317-9 | 2022 | |
| Development and evaluation of mucoadhesive bigel containing tenofovir and maraviroc for HIV prophylaxis. | Ilomuanya MO, Hameedat AT, Akang EN, Ekama SO, Silva BO, Akanmu AS. | Futur J Pharm Sci | 10.1186/s43094-020-00093-3 | 2020 | | |
| Three-dimensional models of the cervicovaginal epithelia to study host-microbiome interactions and sexually transmitted infections. | Edwards VL, McComb E, Gleghorn JP, Forney L, Bavoil PM, Ravel J. | Pathog Dis | 10.1093/femspd/ftac026 | 2022 | | |
| Development and Characterization of Hydroxyethyl Cellulose-Based Gels Containing Lactobacilli Strains: Evaluation of Antimicrobial Effects in In Vitro and Ex Vivo Models. | Sousa MADS, Ferreira AF, da Silva CC, Silva MA, Bazan TAXN, Monteiro CA, Monteiro AS, Sousa JCS, da Silva LCN, Zagmignan A. | Pharmaceuticals (Basel) | 10.3390/ph16030468 | 2023 | | |
| Pathogenicity | Cationic amphiphiles against Gardnerella vaginalis resistant strains and bacterial vaginosis-associated pathogens. | Weeks RM, Moretti A, Song S, Uhrich KE, Karlyshev AV, Chikindas ML. | Pathog Dis | 10.1093/femspd/ftz059 | 2019 | |
| Development and Evaluation of a Thermosensitive In Situ Gel Formulation for Intravaginal Delivery of Lactobacillus gasseri. | Zhao Y, Wang T, Chen Z, Ren H, Song P, Zhu Y, Liang S, Tzeng C. | Pharmaceutics | 10.3390/pharmaceutics14091934 | 2022 | | |
| Pathogenicity | Gemini Cationic Amphiphiles Control Biofilm Formation by Bacterial Vaginosis Pathogens. | Algburi A, Zhang Y, Weeks R, Comito N, Zehm S, Pinto J, Uhrich KE, Chikindas ML. | Antimicrob Agents Chemother | 10.1128/aac.00650-17 | 2017 | |
| Altered Innate Immunity and Damaged Epithelial Integrity in Vaginal Microbial Dysbiosis. | Cheu RK, Mohammadi A, Schifanella L, Broedlow C, Driscoll CB, Miller CJ, Reeves RK, Yudin MH, Hensley-McBain T, Kaul R, Klatt NR. | Front Reprod Health | 10.3389/frph.2022.876729 | 2022 | | |
| Enzymology | Lactobacillus crispatus dominant vaginal microbiome is associated with inhibitory activity of female genital tract secretions against Escherichia coli. | Ghartey JP, Smith BC, Chen Z, Buckley N, Lo Y, Ratner AJ, Herold BC, Burk RD. | PLoS One | 10.1371/journal.pone.0096659 | 2014 | |
| Pathogenicity | Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (group B streptococcus), Haemophilus ducreyi, and vaginal Lactobacillus by 3-O-octyl-sn-glycerol. | Moncla BJ, Pryke K, Isaacs CE. | Antimicrob Agents Chemother | 10.1128/aac.01023-07 | 2008 | |
| Metabolism | Enterococcus faecalis inhibits superantigen toxic shock syndrome toxin-1-induced interleukin-8 from human vaginal epithelial cells through tetramic acids. | Brosnahan AJ, Merriman JA, Salgado-Pabon W, Ford B, Schlievert PM. | PLoS One | 10.1371/journal.pone.0061255 | 2013 | |
| Pyocyanin Inhibits Chlamydia Infection by Disabling Infectivity of the Elementary Body and Disrupting Intracellular Growth. | Li JL, Yang N, Huang L, Chen D, Zhao Y, Tang MM, Fan H, Bao X. | Antimicrob Agents Chemother | 10.1128/aac.02260-17 | 2018 | | |
| Pathogenicity | Testing of viscous anti-HIV microbicides using Lactobacillus. | Moncla BJ, Pryke K, Rohan LC, Yang H. | J Microbiol Methods | 10.1016/j.mimet.2011.12.013 | 2012 | |
| Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism. | Cheu RK, Gustin AT, Lee C, Schifanella L, Miller CJ, Ha A, Kim C, Rodriguez VJ, Fischl M, Burgener AD, Arnold KB, Alcaide ML, Klatt NR. | PLoS Pathog | 10.1371/journal.ppat.1009024 | 2020 | | |
| Quantitative survival of aerobic and anaerobic microorganisms in Port-A-Cul and Copan transport systems. | Stoner KA, Rabe LK, Austin MN, Meyn LA, Hillier SL. | J Clin Microbiol | 10.1128/jcm.00161-08 | 2008 | | |
| Enzymology | Preformulation Characterization of Griffithsin, a Biopharmaceutical Candidate for HIV Prevention. | Kramzer LF, Hamorsky KT, Graebing PW, Wang L, Fuqua JL, Matoba N, Lasnik AB, Moncla BJ, Zhang J, Palmer KE, Rohan LC. | AAPS PharmSciTech | 10.1208/s12249-021-01931-0 | 2021 | |
| Metabolism | Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pathogens and Candida albicans but not Lactobacillus. | Wira CR, Ghosh M, Smith JM, Shen L, Connor RI, Sundstrom P, Frechette GM, Hill ET, Fahey JV. | Mucosal Immunol | 10.1038/mi.2010.72 | 2011 | |
| Phylogeny | DNA fingerprinting of Lactobacillus crispatus strain CTV-05 by repetitive element sequence-based PCR analysis in a pilot study of vaginal colonization. | Antonio MA, Hillier SL. | J Clin Microbiol | 10.1128/jcm.41.5.1881-1887.2003 | 2003 | |
| Metabolism | Hydrogen peroxide-producing lactobacilli inhibit gonococci in vitro but not during experimental genital tract infection. | Muench DF, Kuch DJ, Wu H, Begum AA, Veit SJ, Pelletier ME, Soler-Garcia AA, Jerse AE. | J Infect Dis | 10.1086/597390 | 2009 | |
| Transkingdom network reveals bacterial players associated with cervical cancer gene expression program. | Lam KC, Vyshenska D, Hu J, Rodrigues RR, Nilsen A, Zielke RA, Brown NS, Aarnes EK, Sikora AE, Shulzhenko N, Lyng H, Morgun A. | PeerJ | 10.7717/peerj.5590 | 2018 | | |
| Metabolism | Activity of Genital Tract Secretions and Synthetic Antimicrobial Peptides against Group B Streptococcus. | Agarwal N, Buckley N, Nakra N, Gialanella P, Yuan W, Ghartey JP. | Am J Reprod Immunol | 10.1111/aji.12427 | 2015 | |
| Pathogenicity | Candidate vaginal microbicides with activity against Chlamydia trachomatis and Neisseriagonorrhoeae. | Chu H, Slepenkin A, Elofsson M, Keyser P, de la Maza LM, Peterson EM. | Int J Antimicrob Agents | 10.1016/j.ijantimicag.2010.03.018 | 2010 | |
| Metabolism | Hyaluronidase-sensitive nanoparticle templates for triggered release of HIV/AIDS microbicide in vitro. | Agrahari V, Zhang C, Zhang T, Li W, Gounev TK, Oyler NA, Youan BB. | AAPS J | 10.1208/s12248-013-9546-7 | 2014 | |
| Pathogenicity | Molecular Assay for Detection of Genetic Markers Associated with Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae. | Peterson SW, Martin I, Demczuk W, Bharat A, Hoang L, Wylie J, Allen V, Lefebvre B, Tyrrell G, Horsman G, Haldane D, Garceau R, Wong T, Mulvey MR. | J Clin Microbiol | 10.1128/jcm.00493-15 | 2015 | |
| Pathogenicity | Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. | Chamoun-Emanuelli AM, Bobardt M, Moncla B, Mankowski MK, Ptak RG, Gallay P, Chen Z. | Antimicrob Agents Chemother | 10.1128/aac.02000-13 | 2014 | |
| Metabolism | Formulation and characterization of polymeric films containing combinations of antiretrovirals (ARVs) for HIV prevention. | Akil A, Agashe H, Dezzutti CS, Moncla BJ, Hillier SL, Devlin B, Shi Y, Uranker K, Rohan LC. | Pharm Res | 10.1007/s11095-014-1474-4 | 2015 | |
| Pathogenicity | Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission. | Zhang W, Hu M, Shi Y, Gong T, Dezzutti CS, Moncla B, Sarafianos SG, Parniak MA, Rohan LC. | Pharm Res | 10.1007/s11095-015-1678-2 | 2015 | |
| Removal of group B streptococci colonizing the vagina and oropharynx of mice with a bacteriophage lytic enzyme. | Cheng Q, Nelson D, Zhu S, Fischetti VA. | Antimicrob Agents Chemother | 10.1128/aac.49.1.111-117.2005 | 2005 | | |
| Metabolism | Optimization of media for detection of hydrogen peroxide production by Lactobacillus species. | Rabe LK, Hillier SL. | J Clin Microbiol | 10.1128/jcm.41.7.3260-3264.2003 | 2003 | |
| Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. | Petrova MI, Lievens E, Malik S, Imholz N, Lebeer S. | Front Physiol | 10.3389/fphys.2015.00081 | 2015 | | |
| Comparative study of vaginal Lactobacillus phages isolated from women in the United States and Turkey: prevalence, morphology, host range, and DNA homology. | Kilic AO, Pavlova SI, Alpay S, Kilic SS, Tao L. | Clin Diagn Lab Immunol | 10.1128/cdli.8.1.31-39.2001 | 2001 | | |
| Genetics | Multiomics Analysis-Based Biomarkers in Diagnosis of Polycystic Ovary Syndrome. | Rani S, Chandna P. | Reprod Sci | 10.1007/s43032-022-00863-9 | 2023 | |
| Ameliorative Effect of Surface Proteins of Probiotic Lactobacilli in Colitis Mouse Models. | Chandhni PR, Pradhan D, Sowmya K, Gupta S, Kadyan S, Choudhary R, Gupta A, Gulati G, Mallappa RH, Kaushik JK, Grover S. | Front Microbiol | 10.3389/fmicb.2021.679773 | 2021 | | |
| Metabolism | Characterization, yield optimization, scale up and biopreservative potential of fermencin SA715, a novel bacteriocin from Lactobacillus fermentum GA715 of goat milk origin. | Wayah SB, Philip K. | Microb Cell Fact | 10.1186/s12934-018-0972-1 | 2018 | |
| Metabolism | Surface-layer protein produced by Lactobacillus crispatus JCM 2009 ameliorates lipopolysaccharide-induced inflammation through autophagy cross-talk with the NF-kappaB signaling pathway. | Wang H, Zhang L, Li Q, Xu S, Lu R | Int J Biol Macromol | 10.1016/j.ijbiomac.2020.10.221 | 2020 | |
| Pathogenicity | Characterization and in vitro evaluation of a vaginal gel containing Lactobacillus crispatus for the prevention of gonorrhea. | N'Guessan Gnaman KC, Bouttier S, Yeo A, Aka Any-Grah AAS, Geiger S, Huang N, Nicolas V, Villebrun S, Faye-Kette H, Ponchel G, Koffi AA, Agnely F | Int J Pharm | 10.1016/j.ijpharm.2020.119733 | 2020 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive162742.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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