Streptomyces ladakanus (DSM 40587, ATCC 27441, CBS 777.72)

Name: Streptomyces ladakanus (DSM 40587, ATCC 27441, CBS 777.72)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 16162

Type strain

Culture col. no. DSM 40587 ATCC 27441 CBS 777.72 IFO 13476 ISP 5587 9 more

NCBI tax ID(s) 35621

Special Collections DSMZ JCM Wink compendium

History DSMZ <- E.B. Shirling, ISP (Streptoverticillium ladakanum) <- NRRL <- Upjohn Co., UC 2654 JCM <-- KCC S-0778 <-- IFO 13476 <-- SAJ <-- ISP 5587 <-- NRRL 3191 <-- Upjohn Co., USA; UC 2654.

Links

Streptomyces ladakanus DSM 40587 is a bacterium that builds an aerial mycelium.

genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 45806

ATCC 27441,IFO 13476,NRRL 3191,DSM 40587,JCM 4778,CCRC 12422,VKM Ac-879,NRRL B-3191,CBS 777.72,CECT 3263,NBRC 13476,BCRC 12422

@ref 20215

Last LPSN update 2026-05-29 08:28:42

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Kitasatosporales

Family Streptomycetaceae

Genus Streptomyces

Species Streptomyces ladakanus

Full scientific name Streptomyces ladakanus corrig. (Hanka et al. 1966) Witt and Stackebrandt 1991

Synonyms (5)

Streptomyces ladakanum
Streptoverticillium ladakanum
Streptomyces mobaraensis
Streptoverticillium ladakanus
Streptoverticillium mobaraense

Morphology

Cell morphology

@ref	Motility	Confidence	Gram stain
125439		92.688
125439		99.346	positive

Colony morphology

@ref	Colony color	Medium used
69221	Fawn brown (8007)	suter with tyrosine
69221	Brown beige (1011)	ISP 4
69221	Ochre brown (8001)	ISP 2
69221	Ochre yellow (1024)	ISP 6
69221	Olive brown (8008), nut brown (8011)	ISP 5
69221	Olive brown (8008), nut brown (8011)	ISP 7
69221	Pastel yellow (1034), beige (1001)	ISP 3
69221	Sepia brown (8014)	suter without tyrosine

Multicellular morphology

@ref	Complex name	Complex color	Medium name
69221	Aerial mycelium	Signal white (9003)	ISP 2
69221	Aerial mycelium	Oyster white (1013)	ISP 3
69221	Aerial mycelium	Oyster white (1013)	ISP 4
69221	Aerial mycelium	Telegrey 2 (7046), telegrey 4 (7047)	ISP 5
69221	Aerial mycelium		ISP 6
69221	Aerial mycelium	Agate grey (7038), light grey (7035)	ISP 7
69221	Aerial mycelium		suter with tyrosine
69221	Aerial mycelium	Light grey (7035)	suter without tyrosine

Pigmentation

@ref	Production	Color	Name
69221			melanin pigment
69221		Green brown (8000), brown beige (1011), clay brown (8003)	soluble pigment

Multimedia

@ref:	9664
multimedia content:	DSM_40587.jpg
multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40587.jpg
caption:	Medium 987 28°C
intellectual property rights:	© Leibniz-Institut DSMZ
manual_annotation:	1

@ref:	69221
multimedia content:	DSM_40587_image5.jpeg
multimedia.multimedia content:	DSM_40587_image5.jpeg
caption:	(ISP6, ISP7)
intellectual property rights:	Helmholtz-Zentrum für Infektionsforschung GmbH
manual_annotation:	1

@ref:	69221
multimedia content:	DSM_40587_image6.jpeg
multimedia.multimedia content:	DSM_40587_image6.jpeg
caption:	(ISP6, ISP7)
intellectual property rights:	Helmholtz-Zentrum für Infektionsforschung GmbH
manual_annotation:	1

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
9664	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
9664	positive	growth	28
67770	positive	growth	28

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	facultative anaerobe	96.396

Compound production

9664

Compound5 azacytidine

Halophily

@ref	Salt	Growth	Tested relation	Concentration
69221	NaCl	positive	growth	0 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
69221	22599 ChEBI	arabinose	-	growth
69221	62968 ChEBI	cellulose	+/-	growth
68379	17634 ChEBI	D-glucose	-	fermentation	from API Coryne
68379	16899 ChEBI	D-mannitol	-	fermentation	from API Coryne
68379	16988 ChEBI	D-ribose	-	fermentation	from API Coryne
68379	65327 ChEBI	D-xylose	-	fermentation	from API Coryne
68379	4853 ChEBI	esculin	-	hydrolysis	from API Coryne
69221	28757 ChEBI	fructose	+/-	growth
68379	5291 ChEBI	gelatin	-	hydrolysis	from API Coryne
69221	17234 ChEBI	glucose	+	growth
68379	28087 ChEBI	glycogen	-	fermentation	from API Coryne
68379	17716 ChEBI	lactose	-	fermentation	from API Coryne
68379	17306 ChEBI	maltose	-	fermentation	from API Coryne
69221	37684 ChEBI	mannose	-	growth
69221	17268 ChEBI	myo-inositol	+/-	growth
68379	17632 ChEBI	nitrate	-	reduction	from API Coryne
69221	16634 ChEBI	raffinose	+/-	growth
69221	26546 ChEBI	rhamnose	+/-	growth
68379	17992 ChEBI	sucrose	-	fermentation	from API Coryne
69221	17992 ChEBI	sucrose	+/-	growth
68379	16199 ChEBI	urea	-	hydrolysis	from API Coryne
69221	18222 ChEBI	xylose	+/-	growth

Metabolite production

@ref	Chebi-ID	Metabolite	Production
67770	2038 ChEBI	5-azacytidine

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68379	alkaline phosphatase	+	3.1.3.1	from API Coryne
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68379	alpha-glucosidase	+	3.2.1.20	from API Coryne
68382	alpha-mannosidase	+	3.2.1.24	from API zym
68379	beta-galactosidase	-	3.2.1.23	from API Coryne
68379	beta-glucosidase	-	3.2.1.21	from API Coryne
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68379	beta-glucuronidase	-	3.2.1.31	from API Coryne
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
68379	gelatinase	-		from API Coryne
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
68379	pyrazinamidase	-	3.5.1.B15	from API Coryne
68379	pyrrolidonyl arylamidase	+	3.4.19.3	from API Coryne
68379	urease	-	3.5.1.5	from API Coryne
68382	valine arylamidase	+		from API zym

API coryne

@ref	Reduction of nitrateNIT	PYZ	PYRA	PAL	beta GUR	beta GAL	alpha GLU	beta NAG	ESC	URE	GEL	Control fermentationControl	GLU	RIB	XYL	MAN	MAL	LAC	SAC	GLYG	CAT
69221	-	-	+	+	-	-	+	+/-	-	-	-	not determinedn.d.	-	-	-	-	-	-	-	-	not determinedn.d.

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
69221	not determinedn.d.	+	+	+	-	+	+	+/-	+/-	+/-	+	+	-	+/-	-	+	+/-	-	+	-

Isolation, sampling and environmental information

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
9664	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	Streptomyces mobaraensis strain DSM 40587	complete		35621.13		35621	97.87
66792	Streptomyces mobaraensis strain DSM 40587	complete		35621.11		35621	97.87
66792	Streptomyces mobaraensis strain DSM 40587	complete		35621.12		35621	97.87
66792	ASM2009939v1 assembly for Streptomyces mobaraensis DSM 40587	complete	GCA_020099395	35621.10	8111630205	35621	97.66
66792	ASM2275952v1 assembly for Streptomyces mobaraensis DSM 40587	complete	GCA_022759525	35621.24	8115831668	35621	97.11

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptomyces mobaraensis gene for 16S rRNA, partial sequence, strain: NBRC 13476	AB184430	1475	35621
20218	Streptoverticillium ladakanum var. ladakanum partial 16S rRNA	X53167	1357	35621
124043	Streptomyces mobaraensis gene for 16S ribosomal RNA, partial sequence, strain: JCM 4778.	D44355	120	35621

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Streptomyces mobaraensis strain DSM 40587
BV-BRC: 35621.11

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	96.40	no
125439	gram_stain	BacteriaNetⓘ	positive	99.35	no
125439	spore_formation	BacteriaNetⓘ	yes	88.65	no
125439	motility	BacteriaNetⓘ	no	92.69	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptomyces mobaraensis DSM 40587
NCBI: GCA_020099395.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	89.15	no
125438	anaerobic	anaerobicⓘ	no	96.86	no
125438	aerobic	aerobicⓘ	yes	87.95	no
125438	spore-forming	spore-formingⓘ	yes	89.16	no
125438	thermophilic	thermophileⓘ	no	97.00	yes
125438	flagellated	motile2+ⓘ	no	88.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Characterisation and optimisation of microbial production of transglutaminase produced by Streptoverticillium cinnamoneum.	Kolotylo V, Synowiec A, Piwowarek K, Gientka I, Kieliszek M.	Appl Microbiol Biotechnol	10.1007/s00253-025-13606-y	2025
	Identification of multiple regulatory genes involved in TGase production in Streptomyces mobaraensis DSM 40587.	Liu X, Wang D, Zhang Y, Zhuang X, Bai L.	Eng Microbiol	10.1016/j.engmic.2023.100098	2023
	Safety evaluation of the food enzyme protein-glutamine gamma-glutamyltransferase from the non-genetically modified Streptomyces mobaraensis strain M2020197.	EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Lambre C, Barat Baviera JM, Bolognesi C, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lampi E, Mengelers M, Mortensen A, Riviere G, Steffensen IL, Tlustos C, Van Loveren H, Vernis L, Zorn H, Herman L, Roos Y, Aguilera J, Andryszkiewicz M, Cavanna D, Kovalkovicova N, Liu Y, di Piazza G, Chesson A.	EFSA J	10.2903/j.efsa.2024.8509	2024
	Production of microbial transglutaminase by Streptoverticillium cinnamoneum KKP 1658.	Kolotylo V, Piwowarek K, Kieliszek M.	EXCLI J	10.17179/excli2024-7033	2024
	Microbiological transglutaminase: Biotechnological application in the food industry.	Kolotylo V, Piwowarek K, Kieliszek M.	Open Life Sci	10.1515/biol-2022-0737	2023
Metabolism	Enhanced Production of Transglutaminase in Streptomyces mobaraensis through Random Mutagenesis and Site-Directed Genetic Modification.	Yin X, Li Y, Zhou J, Rao S, Du G, Chen J, Liu S	J Agric Food Chem	10.1021/acs.jafc.1c00645	2021
Metabolism	Enzymatic characterization of transglutaminase from Streptomyces mobaraensis DSM 40587 in high salt and effect of enzymatic cross-linking of yak milk proteins on functional properties of stirred yogurt.	Zhang L, Zhang L, Yi H, Du M, Ma C, Han X, Feng Z, Jiao Y, Zhang Y	J Dairy Sci	10.3168/jds.2011-5125	2012

References

#9664	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40587
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68379	Automatically annotated from API Coryne .
#68382	Automatically annotated from API zym .
#69221	Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptomyces ladakanus (DSM 40587, ATCC 27441, CBS 777.72)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Multicellular morphology

Pigmentation

Multimedia

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Compound production

Halophily

Metabolite utilization

Metabolite production

Enzymes

API coryne

API zym

Isolation, sampling and environmental information

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_020099395

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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