Streptomyces cinnamoneus subsp. cinnamoneus (DSM 40005, ATCC 11874, ATCC 23897)

Name: Streptomyces cinnamoneus subsp. cinnamoneus (DSM 40005, ATCC 11874, ATCC 23897)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 16148

Type strain

Strain Designation A-725

Culture col. no. DSM 40005 ATCC 11874 ATCC 23897 CBS 293.64 CBS 683.68 32 more

NCBI tax ID(s) 53446

Special Collections DSMZ CCUG JCM CIP

History <- E. B. Shirling, ISP <- NRRL <- R. G. Benedict, A-725 KCC S-0152 <-- R. Shinobu <-- NRRL B-1285 <-- R. G. Benedict A-725. CIP <- 2003, JCM <- 1983, KCC <- IFO <- SAJ <- ISP <- NRRL <- R.G. Benedict: strain A-725

Links

Streptomyces cinnamoneus subsp. cinnamoneus A-725 is an obligate aerobe, Gram-positive, rod-shaped bacterium that produces antibiotic compounds and was isolated from soil.

antibiotic compound production Gram-positive rod-shaped obligate aerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 13852

LMG 5971,ATCC 11874,ATCC 23897,DSM 40005,IFO 12852,JCM 4152,JCM 4633,NCIB 8851,NRRL B-1285,LMG 8602,CCUG 11122,DSM 41431,CCRC 12169,IMET 41381,NCIMB 8851,VKM Ac-876,CBS 293.64,AS 4.1084,CECT 3258,AS 4.1706,NBRC 12852,HAMBI 1067,BCRC 12169,CIP 108152,CGMCC 4.1084

@ref 20215

Last LPSN update 2026-02-09 11:21:54

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Kitasatosporales

Family Streptomycetaceae

Genus Streptomyces

Species Streptomyces cinnamoneus subsp. cinnamoneus

Full scientific name Streptomyces cinnamoneus subsp. cinnamoneus (Benedict et al. 1952) Witt and Stackebrandt 1991

Synonyms (1)

Streptoverticillium cinnamoneum subsp. cinnamoneum

BacDive ID	Other strains from **Streptomyces cinnamoneus subsp. cinnamoneus** (7)	Type strain
16149	S. cinnamoneus subsp. cinnamoneus H-2609, DSM 40114, ATCC 19769, CBS 507.68, ...
16150	S. cinnamoneus subsp. cinnamoneus 722, DSM 40507, ATCC 27436, CBS 721.72, IFO ...
16151	S. cinnamoneus subsp. cinnamoneus DSM 40646, ATCC 12686, CBS 369.58, NRRL B-1699, ...
16152	S. cinnamoneus subsp. cinnamoneus HA-145, DSM 40897, ATCC 25186, IPV 2066, ...
16153	S. cinnamoneus subsp. cinnamoneus HA-176, DSM 40898, ATCC 25187, IPV 2067, ...
16154	S. cinnamoneus subsp. cinnamoneus HA-106, DSM 40899, ATCC 25185, IPV 2068, ...
16155	S. cinnamoneus subsp. cinnamoneus B-386, DSM 41501, JCM 5074, KCC S-1074, NRRL ...

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
125439	positive		99.9
125439			91.9
118289	positive	rod-shaped

Colony morphology

Multimedia

@ref:	9210
multimedia content:	DSM_40005.jpg
multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40005.jpg
caption:	Medium 65 28°C
intellectual property rights:	© Leibniz-Institut DSMZ
manual_annotation:	1

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
9210	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)	Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
36995	MEDIUM 56 - for Micromonospora purpurea		Distilled water make up to (1000.000 ml);Agar (15.000 g);Glucose (10.000g);Yeast extract (5.000 g);Starch maize (20.000 g);Calcium carbonate (1.000 g);Casamino acids (5.000 g)
9210	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)	Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water
118289	CIP Medium 56	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
9210	positive	growth	28
36995	positive	growth	30
67770	positive	growth	28
118289	positive	growth	25-37
118289	negative	growth	10
118289	negative	growth	41
118289	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
118289	obligate aerobe
125438	aerobe	90.474
125439	obligate aerobe	99.8

Spore formation

@ref	Spore formation	Confidence
125438		92.013
125439		96.9

Compound production

@ref	Compound
9210	cinnomycin
9210	fungichromin
9210	carbomycin derivatives
20216	Cinnamycin
20216	Fungichromin

Halophily

@ref	Salt	Tested relation	Concentration
118289	NaCl	growth	0 %
118289	NaCl	growth	2 %
118289	NaCl	growth	4 %
118289	NaCl	growth	6 %
118289	NaCl	growth	8 %
118289	NaCl	growth	10 %

Observation

67770

Observationquinones: MK-9(H₆), MK-9(H₈), MK-9(H₄)

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
118289	16947 ChEBI	citrate	-	carbon source
118289	4853 ChEBI	esculin	-	hydrolysis
118289	606565 ChEBI	hippurate	+	hydrolysis
118289	17632 ChEBI	nitrate	-	reduction
118289	17632 ChEBI	nitrate	-	respiration
118289	16301 ChEBI	nitrite	-	reduction

Metabolite production

@ref	Chebi-ID	Metabolite
67770	141991 ChEBI	cinnamycin
67770	31639 ChEBI	fungichromin
118289	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test
118289	15688 ChEBI	acetoin	-
118289	17234 ChEBI	glucose		-

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
118289	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
118289	amylase	+
68382	beta-galactosidase	-	3.2.1.23	from API zym
118289	beta-galactosidase	-	3.2.1.23
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
118289	caseinase	-	3.4.21.50
118289	catalase	+	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
118289	DNase	+
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
118289	gamma-glutamyltransferase	+	2.3.2.2
118289	gelatinase	+/-
118289	lecithinase	+
68382	leucine arylamidase	+	3.4.11.1	from API zym
118289	lipase	+
68382	lipase (C 14)	-		from API zym
118289	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
118289	ornithine decarboxylase	-	4.1.1.17
118289	oxidase	-
118289	phenylalanine ammonia-lyase	-	4.3.1.24
118289	protease	+
68382	trypsin	-	3.4.21.4	from API zym
118289	tryptophan deaminase	-
118289	tween esterase	+
118289	urease	-	3.5.1.5
68382	valine arylamidase	-		from API zym

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	threonine metabolism	100	10 of 10
66794	ethanol fermentation	100	2 of 2
66794	aspartate and asparagine metabolism	100	9 of 9
66794	enterobactin biosynthesis	100	3 of 3
66794	acetate fermentation	100	4 of 4
66794	palmitate biosynthesis	100	22 of 22
66794	ppGpp biosynthesis	100	4 of 4
66794	methylglyoxal degradation	100	5 of 5
66794	valine metabolism	100	9 of 9
66794	metabolism of amino sugars and derivatives	100	5 of 5
66794	biotin biosynthesis	100	4 of 4
66794	molybdenum cofactor biosynthesis	100	9 of 9
66794	cardiolipin biosynthesis	100	7 of 7
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	myo-inositol biosynthesis	100	10 of 10
66794	aerobactin biosynthesis	100	1 of 1
66794	ceramide biosynthesis	100	1 of 1
66794	suberin monomers biosynthesis	100	2 of 2
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	coenzyme A metabolism	100	4 of 4
66794	formaldehyde oxidation	100	3 of 3
66794	glycine betaine biosynthesis	100	5 of 5
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	pentose phosphate pathway	100	11 of 11
66794	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
66794	adipate degradation	100	2 of 2
66794	glycogen metabolism	100	5 of 5
66794	cellulose degradation	100	5 of 5
66794	ribulose monophosphate pathway	100	2 of 2
66794	folate polyglutamylation	100	1 of 1
66794	phenylalanine metabolism	92.31	12 of 13
66794	leucine metabolism	92.31	12 of 13
66794	starch degradation	90	9 of 10
66794	4-hydroxymandelate degradation	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	NAD metabolism	88.89	16 of 18
66794	serine metabolism	88.89	8 of 9
66794	gluconeogenesis	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	glutamate and glutamine metabolism	85.71	24 of 28
66794	heme metabolism	85.71	12 of 14
66794	reductive acetyl coenzyme A pathway	85.71	6 of 7
66794	photosynthesis	85.71	12 of 14
66794	propanol degradation	85.71	6 of 7
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	vitamin B12 metabolism	85.29	29 of 34
66794	alanine metabolism	82.76	24 of 29
66794	proline metabolism	81.82	9 of 11
66794	3-chlorocatechol degradation	80	4 of 5
66794	flavin biosynthesis	80	12 of 15
66794	factor 420 biosynthesis	80	4 of 5
66794	hydrogen production	80	4 of 5
66794	Entner Doudoroff pathway	80	8 of 10
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	arginine metabolism	79.17	19 of 24
66794	purine metabolism	78.72	74 of 94
66794	citric acid cycle	78.57	11 of 14
66794	glutathione metabolism	78.57	11 of 14
66794	d-mannose degradation	77.78	7 of 9
66794	CO2 fixation in Crenarchaeota	77.78	7 of 9
66794	allantoin degradation	77.78	7 of 9
66794	glycolysis	76.47	13 of 17
66794	tryptophan metabolism	76.32	29 of 38
66794	glycogen biosynthesis	75	3 of 4
66794	sulfopterin metabolism	75	3 of 4
66794	ketogluconate metabolism	75	6 of 8
66794	degradation of aromatic, nitrogen containing compounds	75	9 of 12
66794	CMP-KDO biosynthesis	75	3 of 4
66794	butanoate fermentation	75	3 of 4
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	cyclohexanol degradation	75	3 of 4
66794	pyrimidine metabolism	73.33	33 of 45
66794	metabolism of disaccharids	72.73	8 of 11
66794	histidine metabolism	72.41	21 of 29
66794	tetrahydrofolate metabolism	71.43	10 of 14
66794	tyrosine metabolism	71.43	10 of 14
66794	lipid metabolism	70.97	22 of 31
66794	propionate fermentation	70	7 of 10
66794	vitamin B1 metabolism	69.23	9 of 13
66794	isoprenoid biosynthesis	69.23	18 of 26
66794	methionine metabolism	69.23	18 of 26
66794	urea cycle	69.23	9 of 13
66794	lysine metabolism	69.05	29 of 42
66794	oxidative phosphorylation	68.13	62 of 91
66794	octane oxidation	66.67	2 of 3
66794	IAA biosynthesis	66.67	2 of 3
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	cyanate degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	cysteine metabolism	66.67	12 of 18
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	non-pathway related	63.16	24 of 38
66794	glycine metabolism	60	6 of 10
66794	vitamin K metabolism	60	3 of 5
66794	lipoate biosynthesis	60	3 of 5
66794	arachidonate biosynthesis	60	3 of 5
66794	3-phenylpropionate degradation	60	9 of 15
66794	gallate degradation	60	3 of 5
66794	androgen and estrogen metabolism	56.25	9 of 16
66794	nitrate assimilation	55.56	5 of 9
66794	degradation of hexoses	55.56	10 of 18
66794	daunorubicin biosynthesis	55.56	5 of 9
66794	phenol degradation	55	11 of 20
66794	d-xylose degradation	54.55	6 of 11
66794	sulfate reduction	53.85	7 of 13
66794	4-hydroxyphenylacetate degradation	50	5 of 10
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	kanosamine biosynthesis II	50	1 of 2
66794	lactate fermentation	50	2 of 4
66794	pantothenate biosynthesis	50	3 of 6
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	carnitine metabolism	50	4 of 8
66794	toluene degradation	50	2 of 4
66794	resorcinol degradation	50	1 of 2
66794	quinate degradation	50	1 of 2
66794	vitamin E metabolism	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	selenocysteine biosynthesis	50	3 of 6
66794	dTDPLrhamnose biosynthesis	50	4 of 8
66794	coenzyme M biosynthesis	50	5 of 10
66794	ascorbate metabolism	50	11 of 22
66794	polyamine pathway	47.83	11 of 23
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	degradation of pentoses	46.43	13 of 28
66794	phenylpropanoid biosynthesis	46.15	6 of 13
66794	carotenoid biosynthesis	45.45	10 of 22
66794	cholesterol biosynthesis	45.45	5 of 11
66794	lipid A biosynthesis	44.44	4 of 9
66794	degradation of sugar alcohols	43.75	7 of 16
66794	degradation of sugar acids	40	10 of 25
66794	vitamin B6 metabolism	36.36	4 of 11
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	sphingosine metabolism	33.33	2 of 6
66794	chlorophyll metabolism	33.33	6 of 18
66794	phosphatidylethanolamine bioynthesis	30.77	4 of 13
66794	mevalonate metabolism	28.57	2 of 7
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	aclacinomycin biosynthesis	28.57	2 of 7
66794	arachidonic acid metabolism	27.78	5 of 18
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	catecholamine biosynthesis	25	1 of 4
66794	methanogenesis from CO2	25	3 of 12

Fatty acid profile

Metadata FA analysis

@ref

45400

Fatty acid	Percentage	ECL
C15:0 ANTEISO	18.6	14.711
C16:0	15.8	16
C15:0 ISO	14.1	14.621
C16:0 iso	10.7	15.626
C18:2 ω6,9c/C18:0 ANTE	8.3	17.724
C16:1 ω7c	7.7	15.819
C17:0 anteiso	5.7	16.722
C17:0 iso	5.1	16.629
C18:1 ω9c	3.9	17.769
C18:0	3	18
C14:0 ISO	2.7	13.618
C16:0 10-methyl	2.7	16.433
C17:0 CYCLO	1.9	16.888

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
118289	-	+	+	+	-	+	-	-	-	-	+	+	-	-	-	+	-	-	-	-

API biotype100

@ref	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
118289	not determinedn.d.	+	-	-	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	-	-	+	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	+	-	-	-	-	+	+	+	-	+	+	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Soil

Isolation

@ref	Sample type	Country	Country ISO 3 Code	Continent
9210	soil	Japan	JPN	Asia
45400	Soil	Japan	JPN	Asia

Taxonmaps

69479

Global distribution of 16S sequence AY295793 (>99% sequence identity) for Streptomyces from Microbeatlas

Aquatic Samples	991
Soil Samples	2201
Animal Samples	1970
Plant Samples	240
Total Samples	5402

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
9210	1	Risk group (German classification) According to TRBA 466
118289	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1465049v1 assembly for Streptomyces cinnamoneus JCM 4633	scaffold	GCA_014650495	53446.10	2997586797	53446	54.96

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptomyces cinnamoneus strain CGMCC 4.1084 16S ribosomal RNA gene, partial sequence	HQ244443	1389	53446
20218	Streptomyces sp. 40005 16S ribosomal RNA gene, partial sequence	AY295793	1475	232932
20218	Streptomyces cinnamoneus strain DSM 40005 16S ribosomal RNA gene, partial sequence	GU383220	779	53446
20218	Streptomyces cinnamoneus gene for 16S ribosomal RNA, partial sequence, strain: JCM 4152	D44018	120	53446
20218	Streptomyces cinnamoneus gene for 16S rRNA, partial sequence, strain: NBRC 12852	AB184850	1475	53446
20218	Streptomyces cinnamoneus strain NBRC 12852 16S ribosomal RNA gene, partial sequence	JN566034	1357	53446
67770	Streptoverticillium cinnamoneum spp. cinnamoneum partial 16S rRNA	X53171	1354	53446
124043	Streptomyces cinnamoneus strain JCM 4633 16S ribosomal RNA gene, partial sequence.	MT760587	1335	53446

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Streptomyces cinnamoneus JCM 4633
NCBI: GCA_014650495

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	96.90	no
125439	motility	BacteriaNetⓘ	no	91.90	no
125439	gram_stain	BacteriaNetⓘ	positive	99.90	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.80	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptomyces cinnamoneus JCM 4633
NCBI: GCA_014650495.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	89.10	no
125438	anaerobic	anaerobicⓘ	no	97.87	no
125438	aerobic	aerobicⓘ	yes	90.47	yes
125438	spore-forming	spore-formingⓘ	yes	92.01	no
125438	thermophilic	thermophileⓘ	no	97.00	yes
125438	flagellated	motile2+ⓘ	no	89.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Enzymology	Heterologous Production of Microbial Ribosomally Synthesized and Post-translationally Modified Peptides.	Zhang Y, Chen M, Bruner SD, Ding Y.	Front Microbiol	10.3389/fmicb.2018.01801	2018
	In Situ Activation and Heterologous Production of a Cryptic Lantibiotic from an African Plant Ant-Derived Saccharopolyspora Species.	Vikeli E, Widdick DA, Batey SFD, Heine D, Holmes NA, Bibb MJ, Martins DJ, Pierce NE, Hutchings MI, Wilkinson B.	Appl Environ Microbiol	10.1128/aem.01876-19	2020
Genetics	Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms.	Li C, Alam K, Zhao Y, Hao J, Yang Q, Zhang Y, Li R, Li A.	Front Bioeng Biotechnol	10.3389/fbioe.2021.692466	2021
	Screening of natural phenazine producers for electroactivity in bioelectrochemical systems.	Franco A, Elbahnasy M, Rosenbaum MA.	Microb Biotechnol	10.1111/1751-7915.14199	2023
Genetics	Insights into the Biosynthesis of Duramycin.	Huo L, Okesli A, Zhao M, van der Donk WA.	Appl Environ Microbiol	10.1128/aem.02698-16	2017
	The Clostridium difficile cpr locus is regulated by a noncontiguous two-component system in response to type A and B lantibiotics.	Suarez JM, Edwards AN, McBride SM.	J Bacteriol	10.1128/jb.00166-13	2013
	Therapeutic Application of Lantibiotics and Other Lanthipeptides: Old and New Findings.	van Staden ADP, van Zyl WF, Trindade M, Dicks LMT, Smith C.	Appl Environ Microbiol	10.1128/aem.00186-21	2021
Metabolism	Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.	Repka LM, Chekan JR, Nair SK, van der Donk WA.	Chem Rev	10.1021/acs.chemrev.6b00591	2017
Metabolism	Cloning and analysis of the planosporicin lantibiotic biosynthetic gene cluster of Planomonospora alba.	Sherwood EJ, Hesketh AR, Bibb MJ.	J Bacteriol	10.1128/jb.02291-12	2013
	Accessing chemical diversity from the uncultivated symbionts of small marine animals.	Smith TE, Pond CD, Pierce E, Harmer ZP, Kwan J, Zachariah MM, Harper MK, Wyche TP, Matainaho TK, Bugni TS, Barrows LR, Ireland CM, Schmidt EW.	Nat Chem Biol	10.1038/nchembio.2537	2018
	Optimization of fermentation conditions for microbial transglutaminase production by Streptoverticillium cinnamoneum KKP 1658 using response surface methodology (RSM).	Kolotylo V, Piwowarek K, Synowiec A, Kieliszek M.	Folia Microbiol (Praha)	10.1007/s12223-024-01223-7	2025
	Chemistry and biology of the polyene macrolide antibiotics.	Hamilton-Miller JM.	Bacteriol Rev	10.1128/mmbr.37.2.166-196.1973	1973
	Production of Diketopiperazine Derivatives by Pathway Engineering with Different Cyclodipeptide Synthases from Various Streptomyces Strains.	Stierle SA, Harken L, Li SM.	ACS Synth Biol	10.1021/acssynbio.3c00115	2023
	Improvement in hyperexpression with a combination of truncated scmp promoter and Streptomyces lividans.	Uraji M, Yang L, Hatanaka T.	Biosci Biotechnol Biochem	10.1093/bbb/zbac085	2022
	Gene conversion-associated successive engineering of modular polyketide synthases	Jin W, Tu J, Zhang B, Wu X, Chen Y.	Commun Chem		2025
Enzymology	Molecular insights into the mechanism of substrate recognition of Streptomyces transglutaminases.	Tokai S, Uraji M, Hatanaka T.	Biosci Biotechnol Biochem	10.1080/09168451.2019.1697198	2020
	A green replacement route to produce phosphatidylserine in environmentally friendly edible oil-water systems and investigations on the enzymatic mechanism.	Zhang T, Lan H, Wang H, Li B, Gand M, Wang J.	J Food Sci	10.1111/1750-3841.17544	2024
	Cloning and characterization of an acidic lipase from a lipolytic bacterium in tempeh.	Nur N, Suwanto A, Meryandini A, Suhartono MT, Puspitasari E, Kim HK.	J Genet Eng Biotechnol	10.1186/s43141-023-00611-9	2023
	Transplanted Murine Tumours SPECT Imaging with ^99mTc Delivered with an Artificial Recombinant Protein.	Pozdniakova NV, Lipengolts AA, Skribitsky VA, Shpakova KE, Finogenova YA, Smirnova AV, Shevelev AB, Grigorieva EY.	Int J Mol Sci	10.3390/ijms251810197	2024
Genetics	Sex-Specific Effects of Polystyrene Microplastic and Lead(II) Co-Exposure on the Gut Microbiome and Fecal Metabolome in C57BL/6 Mice.	Shen W, Zhao M, Xu W, Shi X, Ren F, Tu P, Gao N, Shan J, Gao B.	Metabolites	10.3390/metabo14040189	2024
	A mutant leucine aminopeptidase from Streptomyces cinnamoneus with enhanced L-aspartyl L-amino acid methyl ester synthetic activity	Arima J, Kono M, Kita M, Mori N.	Biotechnol Lett		2012
Genetics	Two chronically misdiagnosed patients infected with Nocardia cyriacigeorgica accurately diagnosed by whole genome resequencing.	Liu A, Liu X, Lu Y, Gao Z, Tang R, Huang Y, Zheng L, Fan Z, He M.	Front Cell Infect Microbiol	10.3389/fcimb.2022.1032669	2022
Metabolism	A mutant leucine aminopeptidase from Streptomyces cinnamoneus with enhanced L-aspartyl L-amino acid methyl ester synthetic activity.	Arima J, Kono M, Kita M, Mori N.	Biotechnol Lett	10.1007/s10529-012-0877-8	2012
Phylogeny	Differences in the gut microbiomes of dogs and wolves: roles of antibiotics and starch.	Liu Y, Liu B, Liu C, Hu Y, Liu C, Li X, Li X, Zhang X, Irwin DM, Wu Z, Chen Z, Jin Q, Zhang S.	BMC Vet Res	10.1186/s12917-021-02815-y	2021
Metabolism	Creation of endoglucanase-secreting Streptomyces lividans for enzyme production using cellulose as the carbon source.	Noda S, Kawai Y, Miyazaki T, Tanaka T, Kondo A.	Appl Microbiol Biotechnol	10.1007/s00253-013-4880-3	2013
	Orbital actinomycotic mycetoma caused by Streptomyces cinnamoneus.	Walton S, Martin P, Tolson C, Plumridge S, Barrs VR.	JFMS Open Rep	10.1177/2055116915589836	2015
Enzymology	Characterization of an endophytic whorl-forming Streptomyces from Catharanthus roseus stems producing polyene macrolide antibiotic.	Rakotoniriana EF, Chataigne G, Raoelison G, Rabemanantsoa C, Munaut F, El Jaziri M, Urveg-Ratsimamanga S, Marchand-Brynaert J, Corbisier AM, Declerck S, Quetin-Leclercq J.	Can J Microbiol	10.1139/w2012-034	2012
Enzymology	Novel Function of CtXyn5A from Acetivibrio thermocellus: Dual Arabinoxylanase and Feruloyl Esterase Activity in the Same Active Site.	Schmitz E, Leontakianakou S, Adlercreutz P, Nordberg Karlsson E, Linares-Pasten JA.	Chembiochem	10.1002/cbic.202200667	2023
	Study of bicyclomycin biosynthesis in Streptomyces cinnamoneus by genetic and biochemical approaches.	Witwinowski J, Moutiez M, Coupet M, Correia I, Belin P, Ruzzini A, Saulnier C, Caraty L, Favry E, Seguin J, Lautru S, Lequin O, Gondry M, Pernodet JL, Darbon E.	Sci Rep	10.1038/s41598-019-56747-7	2019
	Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209.	Chen YY, Chen LY, Chen PJ, El-Shazly M, Peng BR, Chen YC, Su CH, Su JH, Sung PJ, Yen PT, Wang LS, Lai KH.	Metabolites	10.3390/metabo12040320	2022
Genetics	Investigation of Spaceflight Induced Changes to Astronaut Microbiomes.	Morrison MD, Thissen JB, Karouia F, Mehta S, Urbaniak C, Venkateswaran K, Smith DJ, Jaing C.	Front Microbiol	10.3389/fmicb.2021.659179	2021
	pTONA5: a hyperexpression vector in Streptomycetes.	Hatanaka T, Onaka H, Arima J, Uraji M, Uesugi Y, Usuki H, Nishimoto Y, Iwabuchi M.	Protein Expr Purif	10.1016/j.pep.2008.09.001	2008
Pathogenicity	Microtiter plate bioassay to monitor the interference of antibiotics with the lipid II cycle essential for peptidoglycan biosynthesis.	Burkard M, Stein T.	J Microbiol Methods	10.1016/j.mimet.2008.05.002	2008
	Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state.	Kasmaei KM, Kalyani DC, Reichenbach T, Jimenez-Quero A, Vilaplana F, Divne C.	Front Microbiol	10.3389/fmicb.2022.1050160	2022
Enzymology	High level expression of Streptomyces mobaraensis transglutaminase in Corynebacterium glutamicum using a chimeric pro-region from Streptomyces cinnamoneus transglutaminase.	Date M, Yokoyama K, Umezawa Y, Matsui H, Kikuchi Y.	J Biotechnol	10.1016/j.jbiotec.2004.02.011	2004
	Active secretion of a thermostable transglutaminase variant in Escherichia coli.	Wang X, Zhao B, Du J, Xu Y, Zhu X, Zhou J, Rao S, Du G, Chen J, Liu S.	Microb Cell Fact	10.1186/s12934-022-01801-9	2022
Metabolism	Discovery and Biosynthesis of the Antibiotic Bicyclomycin in Distantly Related Bacterial Classes.	Vior NM, Lacret R, Chandra G, Dorai-Raj S, Trick M, Truman AW.	Appl Environ Microbiol	10.1128/aem.02828-17	2018
Metabolism	Mining of a phospholipase D and its application in enzymatic preparation of phosphatidylserine.	Zhou WB, Gong JS, Hou HJ, Li H, Lu ZM, Xu HY, Xu ZH, Shi JS.	Bioengineered	10.1080/21655979.2017.1308992	2018
Phylogeny	Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis.	Labeda DP, Dunlap CA, Rong X, Huang Y, Doroghazi JR, Ju KS, Metcalf WW.	Antonie Van Leeuwenhoek	10.1007/s10482-016-0824-0	2017
Genetics	Comparative Genomic Analysis of 19 Clinical Isolates of Tigecycline-Resistant Acinetobacter baumannii.	Liu L, Shen P, Zheng B, Yu W, Ji J, Xiao Y.	Front Microbiol	10.3389/fmicb.2020.01321	2020
Genetics	Targeted enzyme gene re-positioning: A computational approach for discovering alternative bacterial enzymes for the synthesis of plant-specific secondary metabolites.	Nakamura Y, Hirose S, Taniguchi Y, Moriya Y, Yamada T.	Metab Eng Commun	10.1016/j.mec.2019.e00102	2019
Metabolism	A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite.	Maglangit F, Fang Q, Kyeremeh K, Sternberg JM, Ebel R, Deng H.	Molecules	10.3390/molecules25020256	2020
Pathogenicity	Natural kirromycin resistance of elongation factor Tu from the kirrothricin producer Streptomyces cinnamoneus.	Cappellano C, Monti F, Sosio M, Donadio S, Sarubbi E.	Microbiology (Reading)	10.1099/00221287-143-2-617	1997
Metabolism	Hyper secretion of Thermobifida fusca beta-glucosidase via a Tat-dependent signal peptide using Streptomyces lividans.	Miyazaki T, Noda S, Tanaka T, Kondo A.	Microb Cell Fact	10.1186/1475-2859-12-88	2013
	Anionic carbohydrate-containing polymers of cell walls in two streptoverticille genospecies.	Kozlova YI, Streshinskaya GM, Shashkov AS, Evtushenko LI, Naumova IB.	Biochemistry (Mosc)		1999
Metabolism	Biochemical properties of a new cold-active mono- and diacylglycerol lipase from marine member Janibacter sp. strain HTCC2649.	Yuan D, Lan D, Xin R, Yang B, Wang Y.	Int J Mol Sci	10.3390/ijms150610554	2014
	Heterologous Expression of a Cryptic Gene Cluster from Streptomyces leeuwenhoekii C34^T Yields a Novel Lasso Peptide, Leepeptin.	Gomez-Escribano JP, Castro JF, Razmilic V, Jarmusch SA, Saalbach G, Ebel R, Jaspars M, Andrews B, Asenjo JA, Bibb MJ.	Appl Environ Microbiol	10.1128/aem.01752-19	2019
Enzymology	Improving the active expression of transglutaminase in Streptomyces lividans by promoter engineering and codon optimization.	Liu S, Wang M, Du G, Chen J.	BMC Biotechnol	10.1186/s12896-016-0304-7	2016
	A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var. beijingensis.	Shen J, Kong L, Li Y, Zheng X, Wang Q, Yang W, Deng Z, You D.	Synth Syst Biotechnol	10.1016/j.synbio.2018.12.004	2019
Metabolism	Structure and chemistry of lysinoalanine crosslinking in the spirochaete flagella hook.	Lynch MJ, Miller M, James M, Zhang S, Zhang K, Li C, Charon NW, Crane BR.	Nat Chem Biol	10.1038/s41589-019-0341-3	2019
	Natural Products from Actinobacteria Associated with Fungus-Growing Termites.	Benndorf R, Guo H, Sommerwerk E, Weigel C, Garcia-Altares M, Martin K, Hu H, Kufner M, de Beer ZW, Poulsen M, Beemelmanns C.	Antibiotics (Basel)	10.3390/antibiotics7030083	2018
Metabolism	Isolation and characterization of novel lipases/esterases from a bovine rumen metagenome.	Prive F, Newbold CJ, Kaderbhai NN, Girdwood SG, Golyshina OV, Golyshin PN, Scollan ND, Huws SA.	Appl Microbiol Biotechnol	10.1007/s00253-014-6355-6	2015
	Challenges with using names to link digital biodiversity information.	Patterson D, Mozzherin D, Shorthouse DP, Thessen A.	Biodivers Data J	10.3897/bdj.4.e8080	2016
Metabolism	Loop of Streptomyces Feruloyl Esterase Plays an Important Role in the Enzyme's Catalyzing the Release of Ferulic Acid from Biomass.	Uraji M, Tamura H, Mizohata E, Arima J, Wan K, Ogawa K, Inoue T, Hatanaka T	Appl Environ Microbiol	10.1128/AEM.02300-17	2018
Metabolism	Nine post-translational modifications during the biosynthesis of cinnamycin.	Okesli A, Cooper LE, Fogle EJ, van der Donk WA	J Am Chem Soc	10.1021/ja205783f	2011
Enzymology	Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005.	Widdick DA, Dodd HM, Barraille P, White J, Stein TH, Chater KF, Gasson MJ, Bibb MJ	Proc Natl Acad Sci U S A	10.1073/pnas.0230516100	2003
Enzymology	Purification, characterisation, and gene cloning of transglutaminase from Streptoverticillium cinnamoneum CBS 683.68.	Duran R, Junqua M, Schmitter JM, Gancet C, Goulas P	Biochimie	10.1016/s0300-9084(98)80073-4	1998
Genetics	Primary structure and reactive site of Streptoverticillium anticoagulant (SAC), a novel protein inhibitor of blood coagulation produced by Streptoverticillium cinnamoneum subsp. cinnamoneum.	Tanabe M, Kawahara K, Asano T, Kato K, Kakinuma A	J Biochem	10.1093/oxfordjournals.jbchem.a124406	1994
Phylogeny	Isolation and characterization of Streptoverticillium anticoagulant (SAC), a novel protein inhibitor of blood coagulation produced by Streptoverticillium cinnamoneum subsp. cinnamoneum.	Tanabe M, Asano T, Moriya N, Sugino H, Kakinuma A	J Biochem	10.1093/oxfordjournals.jbchem.a124405	1994
Phylogeny	Taxonomic re-evaluation of whorl-forming Streptomyces (formerly Streptoverticillium) species by using phenotypes, DNA-DNA hybridization and sequences of gyrB, and proposal of Streptomyces luteireticuli (ex Katoh and Arai 1957) corrig., sp. nov., nom. rev.	Hatano K, Nishii T, Kasai H.	Int J Syst Evol Microbiol	10.1099/ijs.0.02238-0	2003

References

#9210	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40005
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20216	Curators of the HKI: Collection Description Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI) . Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI):
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#36995	; Curators of the CIP;
#45400	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 11122
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#118289	Collection of Institut Pasteur ; Curators of the CIP; CIP 108152
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptomyces cinnamoneus subsp. cinnamoneus (DSM 40005, ATCC 11874, ATCC 23897)

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