Streptomyces toxytricini DSM 40178 is a mesophilic prokaryote that builds an aerial mycelium and was isolated from soil.
mesophilic genome sequence 16S sequence| @ref 20215 |
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| Domain Bacillati |
| Phylum Actinomycetota |
| Class Actinomycetes |
| Order Kitasatosporales |
| Family Streptomycetaceae |
| Genus Streptomyces |
| Species Streptomyces toxytricini |
| Full scientific name Streptomyces toxytricini (Preobrazhenskaya and Sveshnikova 1957) Pridham et al. 1958 (Approved Lists 1980) |
| Synonyms (1) |
| BacDive ID | Other strains from Streptomyces toxytricini (2) | Type strain |
|---|---|---|
| 127167 | S. toxytricini ST006481(HKI), 1332, IMET 41332 | |
| 127168 | S. toxytricini ST003705(HKI), |
| @ref | Colony color | Medium used | |
|---|---|---|---|
| 69250 | Beige (1001), brown beige (1011) | ISP 3 | |
| 69250 | Beige (1001) | suter without tyrosine | |
| 69250 | Grey brown (8019), brown beige (1011) | suter with tyrosine | |
| 69250 | Light ivory (1015) | ISP 2 | |
| 69250 | Light ivory (1015) | ISP 4 | |
| 69250 | Light ivory (1015) | ISP 7 | |
| 69250 | Oyster white (1013) | ISP 5 | |
| 69250 | Pale brown (8025), brown beige (1011) | ISP 6 |
| @ref | Forms multicellular complex | Complex name | Complex color | Medium name | |
|---|---|---|---|---|---|
| 69250 | Aerial mycelium | Signal white (9001), beige red (3012), signal brown (8002) | ISP 2 | ||
| 69250 | Aerial mycelium | Cream (9001), beige red (3012) | ISP 3 | ||
| 69250 | Aerial mycelium | Signal white (9001), beige red (3012), signal brown (8002) | ISP 4 | ||
| 69250 | Aerial mycelium | Cream (9001) | ISP 5 | ||
| 69250 | Aerial mycelium | ISP 6 | |||
| 69250 | Aerial mycelium | Signal white (9001), beige red (3012) | ISP 7 | ||
| 69250 | Aerial mycelium | suter with tyrosine | |||
| 69250 | Aerial mycelium | suter without tyrosine |
| @ref: | 9371 |
| multimedia content: | DSM_40178.jpg |
| multimedia.multimedia content: | https://www.dsmz.de/microorganisms/photos/DSM_40178.jpg |
| caption: | Medium 65 28°C |
| intellectual property rights: | © Leibniz-Institut DSMZ |
| manual_annotation: | 1 |
| @ref: | 69250 |
| multimedia content: | DSM_40178_image5.jpeg |
| multimedia.multimedia content: | DSM_40178_image5.jpeg |
| caption: | (ISP6, ISP7) |
| intellectual property rights: | Helmholtz-Zentrum für Infektionsforschung GmbH |
| manual_annotation: | 1 |
| @ref: | 69250 |
| multimedia content: | DSM_40178_image6.jpeg |
| multimedia.multimedia content: | DSM_40178_image6.jpeg |
| caption: | (ISP6, ISP7) |
| intellectual property rights: | Helmholtz-Zentrum für Infektionsforschung GmbH |
| manual_annotation: | 1 |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 9371 | GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) | Medium recipe at MediaDive | Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water |
| @ref | Oxygen tolerance | Confidence | |
|---|---|---|---|
| 125439 | obligate aerobe | 99.3 |
| @ref | Salt | Growth | Tested relation | Concentration | |
|---|---|---|---|---|---|
| 69250 | NaCl | positive | growth | 0-7.5 % |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 69250 | 22599 ChEBI | arabinose | - | growth | |
| 69250 | 62968 ChEBI | cellulose | - | growth | |
| 68379 | 17634 ChEBI | D-glucose | - | fermentation | from API Coryne |
| 68379 | 16899 ChEBI | D-mannitol | - | fermentation | from API Coryne |
| 68379 | 16988 ChEBI | D-ribose | - | fermentation | from API Coryne |
| 68379 | 65327 ChEBI | D-xylose | - | fermentation | from API Coryne |
| 68379 | 4853 ChEBI | esculin | - | hydrolysis | from API Coryne |
| 69250 | 28757 ChEBI | fructose | - | growth | |
| 68379 | 5291 ChEBI | gelatin | + | hydrolysis | from API Coryne |
| 69250 | 17234 ChEBI | glucose | + | growth | |
| 69250 | 17268 ChEBI | inositol | - | growth | |
| 68379 | 17716 ChEBI | lactose | - | fermentation | from API Coryne |
| 68379 | 17306 ChEBI | maltose | - | fermentation | from API Coryne |
| 69250 | 37684 ChEBI | mannose | - | growth | |
| 68379 | 17632 ChEBI | nitrate | - | reduction | from API Coryne |
| 69250 | 16634 ChEBI | raffinose | - | growth | |
| 69250 | 26546 ChEBI | rhamnose | - | growth | |
| 69250 | 17992 ChEBI | sucrose | - | growth | |
| 68379 | 17992 ChEBI | sucrose | - | fermentation | from API Coryne |
| 68379 | 16199 ChEBI | urea | - | hydrolysis | from API Coryne |
| 69250 | 18222 ChEBI | xylose | - | growth |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 68382 | alkaline phosphatase | + | 3.1.3.1 | from API zym |
| 68379 | alkaline phosphatase | + | 3.1.3.1 | from API Coryne |
| 68382 | alpha-chymotrypsin | + | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68379 | alpha-glucosidase | - | 3.2.1.20 | from API Coryne |
| 68382 | alpha-mannosidase | + | 3.2.1.24 | from API zym |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 68379 | beta-galactosidase | - | 3.2.1.23 | from API Coryne |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68379 | beta-glucosidase | - | 3.2.1.21 | from API Coryne |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 68379 | beta-glucuronidase | - | 3.2.1.31 | from API Coryne |
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | + | from API zym | |
| 68379 | gelatinase | + | from API Coryne | |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68379 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API Coryne |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 68379 | pyrazinamidase | - | 3.5.1.B15 | from API Coryne |
| 68379 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API Coryne |
| 68382 | trypsin | + | 3.4.21.4 | from API zym |
| 68379 | urease | - | 3.5.1.5 | from API Coryne |
| 68382 | valine arylamidase | + | from API zym |
| @ref | Reduction of nitrateNIT | PYZ | PYRA | PAL | beta GUR | beta GAL | alpha GLU | beta NAG | ESC | URE | GEL | Control fermentationControl | GLU | RIB | XYL | MAN | MAL | LAC | SAC | GLYG | CAT | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 69250 | - | - | - | + | - | - | - | - | - | - | + | not determinedn.d. | - | - | - | - | - | - | - | not determinedn.d. | not determinedn.d. |
Global distribution of 16S sequence AB184173 (>99% sequence identity) for Streptomyces from Microbeatlas ![]()
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 66792 | ASM1464991v1 assembly for Streptomyces toxytricini JCM 4421 | scaffold | 67369 | 53.09 |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 20218 | Streptomyces toxytricini gene for 16S rRNA, partial sequence | AB122736 | 564 | 67369 | ||
| 20218 | Streptomyces toxytricini gene for 16S ribosomal RNA, partial sequence, strain: JCM 4421 | D44133 | 120 | 67369 | ||
| 20218 | Streptomyces toxytricini gene for 16S rRNA, partial sequence, strain: NBRC 12823 | AB184173 | 1475 | 67369 | ||
| 20218 | Streptomyces toxytricini strain NRRL B-5426T 16S ribosomal RNA gene, partial sequence | DQ442548 | 1484 | 67369 | ||
| 124043 | Streptomyces toxytricini strain JCM 4421 16S ribosomal RNA gene, partial sequence. | MT760547 | 1378 | 67369 |
| @ref | Trait | Model | Prediction | Confidence in % | In training data |
|---|---|---|---|---|---|
| 125439 | spore_formation | BacteriaNetⓘ | yes | 95.90 | no |
| 125439 | motility | BacteriaNetⓘ | no | 91.20 | no |
| 125439 | gram_stain | BacteriaNetⓘ | positive | 99.70 | no |
| 125439 | oxygen_tolerance | BacteriaNetⓘ | obligate aerobe | 99.30 | no |
| @ref | Trait | Model | Prediction | Confidence in % | In training data |
|---|---|---|---|---|---|
| 125438 | gram-positive | gram-positiveⓘ | yes | 89.14 | no |
| 125438 | anaerobic | anaerobicⓘ | no | 96.80 | no |
| 125438 | aerobic | aerobicⓘ | yes | 89.64 | no |
| 125438 | spore-forming | spore-formingⓘ | yes | 91.59 | no |
| 125438 | thermophilic | thermophileⓘ | no | 96.50 | no |
| 125438 | flagellated | motile2+ⓘ | no | 85.60 | no |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Phylogeny | Streptomyces globosus DK15 and Streptomyces ederensis ST13 as new producers of factumycin and tetrangomycin antibiotics. | Charousova I, Medo J, Hleba L, Javorekova S. | Braz J Microbiol | 10.1016/j.bjm.2017.12.007 | 2018 | |
| Insights into the mechanism of mycelium transformation of Streptomyces toxytricini into pellet. | Kumar P, Khushboo, Rajput D, Dubey KK. | FEMS Microbes | 10.1093/femsmc/xtad017 | 2023 | ||
| Streptomyces toxytricini, a biocontrol plant growth-promoting bacterium against smut of broomcorn millet (Panicum miliaceum L.) | Jin F, Xu L, Xu H, Yang Q, Feng B. | Biol Control | 2025 | |||
| Enhanced Production of Lipstatin Through NTG Treatment of Streptomyces toxytricini KD18 at 5 L Bioreactor Level. | Khushboo, Dubey KK. | Appl Biochem Biotechnol | 10.1007/s12010-023-04442-9 | 2023 | ||
| Soil Actinobacteria Exhibit Metabolic Capabilities for Degrading the Toxic and Persistent Herbicide Metribuzin. | Rebai H, Sholkamy EN, Abdelhamid MAA, Prakasam Thanka P, Aly Hassan A, Pack SP, Ki MR, Boudemagh A. | Toxics | 10.3390/toxics12100709 | 2024 | ||
| One-pot selective biosynthesis of Tyrian purple in Escherichia coli. | Li F, Chen Q, Deng H, Ye S, Chen R, Keasling JD, Luo X. | Metab Eng | 10.1016/j.ymben.2023.11.003 | 2024 | ||
| Analysis of secondary metabolites and morphology in Streptomyces rimosus microparticle-enhanced cultivation (MPEC) at various initial organic nitrogen concentrations. | Scigaczewska A, Boruta T, Grzesiak W, Bizukojc M. | Microb Cell Fact | 10.1186/s12934-024-02514-x | 2024 | ||
| Genetics | Draft genome sequence of Streptomyces sp. KD18, isolated from industrial soil. | Khushboo, Singhvi N, Gupta V, Dhaka N, Dubey KK. | 3 Biotech | 10.1007/s13205-022-03453-3 | 2023 | |
| Discovery of Streptomyces species CS-62, a novel producer of the Acinetobacter baumannii selective antibiotic factumycin. | Alwali AY, Santos D, Aguilar C, Birch A, Rodriguez-Orduna L, Roberts CB, Modi R, Licona-Cassani C, Parkinson EI. | J Ind Microbiol Biotechnol | 10.1093/jimb/kuae014 | 2024 | ||
| Metabolism | Mycelium transformation of Streptomyces toxytricini into pellet: Role of culture conditions and kinetics. | Kumar P, Dubey KK. | Bioresour Technol | 10.1016/j.biortech.2017.01.002 | 2017 | |
| Enhanced production of lipstatin from mutant of Streptomyces toxytricini and fed-batch strategies under submerged fermentation. | Khushboo, Pinki, Kumar P, Tripathi A, Luthra U, Dubey KK. | 3 Biotech | 10.1007/s13205-020-2147-0 | 2020 | ||
| Anti-Obesity, Lipid-Lowering, and Anti-Hyperglycemic Effects of CB-02 in High-Fat-Diet-Induced Obese Mice. | Hiep HL, Bang PV, Nhan ND, Ngan NH, To DC, Dung NV, Phu LH. | Molecules | 10.3390/molecules30183678 | 2025 | ||
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| Development and Optimization of a High-Throughput Screening Assay for Rapid Evaluation of Lipstatin Production by Streptomyces Strains. | Hires M, Rapava N, Simkovic M, Varecka L, Berkes D, Krystofova S. | Curr Microbiol | 10.1007/s00284-017-1420-x | 2018 | ||
| Metabolism | Modulation of fatty acid metabolism and tricarboxylic acid cycle to enhance the lipstatin production through medium engineering in Streptomyces toxytricini. | Kumar P, Dubey KK. | Bioresour Technol | 10.1016/j.biortech.2016.01.133 | 2016 | |
| Effect of Silibinin on Human Pancreatic Lipase Inhibition and Gut Microbiota in Healthy Volunteers: A Randomized Controlled Trial. | Ponce Martinez C, Murcia Garcia E, Perez Sanchez H, Milagro FI, Riezu-Boj JI, Ramos Molina B, Gomez Gallego M, Zamora S, Canavate Cutillas R, Hernandez Morante JJ. | Int J Mol Sci | 10.3390/ijms252312853 | 2024 | ||
| Evaluation of potential inhibitory effects on acetylcholinesterase, pancreatic lipase, and cancer cell lines using raw leaves extracts of three fabaceae species. | Fatima I, Safdar N, Akhtar W, Munir A, Saqib S, Ayaz A, Bahadur S, Alrefaei AF, Ullah F, Zaman W. | Heliyon | 10.1016/j.heliyon.2023.e15909 | 2023 | ||
| Antioxidant and Enzyme Inhibitory Potential of Streptomyces sp. G-18 Grown in Various Media. | Ashok GC, Prakash Pradhan S, Kumar Karki K, Khadka A, Bhandari A, Prasad Pandey B. | Int J Microbiol | 10.1155/2023/6439466 | 2023 | ||
| Mycotransformation of Commercial Grade Cypermethrin Dispersion by Aspergillus terreus PDB-B Strain Isolated from Lake Sediments of Kulamangalam, Madurai. | Kannan P, Baskaran H, Juliana Selvaraj JB, Saeid A, Kiruba Nester JM. | Molecules | 10.3390/molecules29071446 | 2024 | ||
| Enzymology | Recombinant flavin-dependent halogenases are functional in tobacco chloroplasts without co-expression of flavin reductase genes. | Frabel S, Krischke M, Staniek A, Warzecha H. | Biotechnol J | 10.1002/biot.201600337 | 2016 | |
| Metabolism | Enhanced production of lipstatin from Streptomyces toxytricini by optimizing fermentation conditions and medium. | Zhu T, Wang L, Wang W, Hu Z, Yu M, Wang K, Cui Z. | J Gen Appl Microbiol | 10.2323/jgam.60.106 | 2014 | |
| Enzymology | Halogenation of Peptides and Proteins Using Engineered Tryptophan Halogenase Enzymes. | Sana B, Ke D, Li EHY, Ho T, Seayad J, Duong HA, Ghadessy FJ. | Biomolecules | 10.3390/biom12121841 | 2022 | |
| Biological control of Xanthomonas Oryzae pv. Oryzae causing rice bacterial blight disease by Streptomyces toxytricini VN08-A-12, isolated from soil and leaf-litter samples in Vietnam. | Van Hop D, Phuong Hoa PT, Quang ND, Ton PH, Ha TH, Van Hung N, Van NT, Van Hai T, Kim Quy NT, Anh Dao NT, Thi Thom V. | Biocontrol Sci | 10.4265/bio.19.103 | 2014 | ||
| Implication of mutagenesis and precursor supplementation towards the enhancement of lipstatin (an antiobesity agent) biosynthesis through submerged fermentation using Streptomyces toxytricini. | Kumar P, Dubey KK. | 3 Biotech | 10.1007/s13205-017-1049-2 | 2018 | ||
| Genetics | Actinomycetota From Macroalgae as Rich Source for Natural Products Discovery Revealed Through Culture-Dependent and -Independent Approaches. | Girao M, Rego A, Fonseca AC, Cao W, Jia Z, Urbatzka R, Leao PN, Carvalho MF. | Microb Biotechnol | 10.1111/1751-7915.70058 | 2024 | |
| Chemical Profile and Bioactivity of Rubus idaeus L. Fruits Grown in Conventional and Aeroponic Systems. | La Torre C, Loizzo MR, Frattaruolo L, Plastina P, Grisolia A, Armentano B, Cappello MS, Cappello AR, Tundis R. | Plants (Basel) | 10.3390/plants13081115 | 2024 | ||
| Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini | Zeng J, Zhan J. | Biotechnol Lett | 2011 | |||
| Transcriptome | Integrated Analysis of Transcriptome and Metabolome Provides Insight into Camellia oleifera Oil Alleviating Fat Accumulation in High-Fat Caenorhabditis elegans. | Liu L, Kong Q, Xiang Z, Kuang X, Wang H, Zhou L, Feng S, Chen T, Ding C. | Int J Mol Sci | 10.3390/ijms241411615 | 2023 | |
| Advances in Anti-obesity Pharmacotherapy: Current Treatments, Emerging Therapies, and Challenges. | Brandfon S, Eylon A, Khanna D, Parmar MS. | Cureus | 10.7759/cureus.46623 | 2023 | ||
| Metabolism | Biochemical characterization of a type III polyketide biosynthetic gene cluster from Streptomyces toxytricini. | Zeng J, Decker R, Zhan J. | Appl Biochem Biotechnol | 10.1007/s12010-011-9490-x | 2012 | |
| Enzymology | Characterization of a tryptophan 6-halogenase from Streptomyces toxytricini. | Zeng J, Zhan J. | Biotechnol Lett | 10.1007/s10529-011-0595-7 | 2011 | |
| Metabolism | Biochemical characteristization of propionyl-coenzyme a carboxylase complex of Streptomyces toxytricini. | Demirev AV, Khanal A, Hanh NP, Nam KT, Nam DH. | J Microbiol | 10.1007/s12275-011-1122-1 | 2011 | |
| Agaricus bisporus Extract Exerts an Anti-Obesity Effect in High-Fat Diet-Induced Obese C57BL/6N Mice by Inhibiting Pancreatic Lipase-Mediated Fat Absorption. | Kim H, Jeon YE, Kim SM, Jung JI, Ko D, Kim EJ. | Nutrients | 10.3390/nu15194225 | 2023 | ||
| Novel Treatments for Obesity: Implications for Cancer Prevention and Treatment. | Cuttica CM, Briata IM, DeCensi A. | Nutrients | 10.3390/nu15173737 | 2023 | ||
| Fatty Acid Synthase as Interacting Anticancer Target of the Terpenoid Myrianthic Acid Disclosed by MS-Based Proteomics Approaches. | Capuano A, D'Urso G, Gazzillo E, Lauro G, Chini MG, D'Auria MV, Ferraro MG, Iazzetti F, Irace C, Bifulco G, Casapullo A. | Int J Mol Sci | 10.3390/ijms25115918 | 2024 | ||
| Combined Potential of Orlistat with Natural Sources and Their Bioactive Compounds Against Obesity: A Review. | Uuh Narvaez JJ, Chan Zapata I, Segura Campos MR. | Molecules | 10.3390/molecules30112392 | 2025 | ||
| Engineering Saccharomyces cerevisiae for the de novo Production of Halogenated Tryptophan and Tryptamine Derivatives. | Milne N, Saez-Saez J, Nielsen AM, Dyekjaer JD, Rago D, Kristensen M, Wulff T, Borodina I. | ChemistryOpen | 10.1002/open.202200266 | 2023 | ||
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| Pharmacological Treatment of Obesity in Older Adults. | Zizka O, Haluzik M, Jude EB. | Drugs Aging | 10.1007/s40266-024-01150-9 | 2024 | ||
| Phenolic Profile of Nipa Palm Vinegar and Evaluation of Its Antilipidemic Activities. | Chatatikun M, Kwanhian W. | Evid Based Complement Alternat Med | 10.1155/2020/6769726 | 2020 | ||
| Enzymology | Separation and Purification of Lipase Inhibitory Peptide from Fermented Milk by Lactobacillus plantarum Q180. | Kim S, Lim SD. | Food Sci Anim Resour | 10.5851/kosfa.2019.e87 | 2020 | |
| Genetics | Whole genome analysis of Streptomyces sp. RerS4, a Rehmannia glutinosa rhizosphere microbe producing a new lipopeptide. | He H, Huang J, Zhao Z, Du P, Li J, Xin J, Xu H, Feng W, Zheng X. | Heliyon | 10.1016/j.heliyon.2023.e19543 | 2023 | |
| Tryptophan-Centric Bioinformatics Identifies New Lasso Peptide Modifications. | Harris LA, Saad H, Shelton KE, Zhu L, Guo X, Mitchell DA. | Biochemistry | 10.1021/acs.biochem.4c00035 | 2024 | ||
| Antiamylase, Antilipase, Antimicrobial, and Cytotoxic Activity of Nonea obtusifolia (Willd.) DC. from Palestine. | Jaradat N, Abualhasan MN, Qadi M, Issa L, Mousa A, Allan F, Hindi M, Alhrezat Z. | Biomed Res Int | 10.1155/2020/8821319 | 2020 | ||
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| Proteinaceous Pancreatic Lipase Inhibitor from the Seed of Litchi chinensis. | Mhatre SV, Bhagit AA, Yadav RP. | Food Technol Biotechnol | 10.17113/ftb.57.01.19.5909 | 2019 | ||
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| Optimization of betaine-sorbitol natural deep eutectic solvent-based ultrasound-assisted extraction and pancreatic lipase inhibitory activity of chlorogenic acid and caffeine content from robusta green coffee beans. | Ahmad I, Syakfanaya AM, Azminah A, Saputri FC, Mun'im A. | Heliyon | 10.1016/j.heliyon.2021.e07702 | 2021 | ||
| Anti-Obesity Effect of alpha-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes. | Lee SJ, Kim JE, Choi YJ, Gong JE, Jin YJ, Lee DW, Choi YW, Hwang DY. | Biomolecules | 10.3390/biom11111650 | 2021 | ||
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| Isolation, Identification and Pharmacological Effects of Mandragora autumnalis Fruit Flavonoids Fraction. | Al-Maharik N, Jaradat N, Bassalat N, Hawash M, Zaid H. | Molecules | 10.3390/molecules27031046 | 2022 | ||
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| Sequencing introduced false positive rare taxa lead to biased microbial community diversity, assembly, and interaction interpretation in amplicon studies. | Jia Y, Zhao S, Guo W, Peng L, Zhao F, Wang L, Fan G, Zhu Y, Xu D, Liu G, Wang R, Fang X, Zhang H, Kristiansen K, Zhang W, Chen J. | Environ Microbiome | 10.1186/s40793-022-00436-y | 2022 | ||
| Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19). | Kim J, Zhang J, Cha Y, Kolitz S, Funt J, Escalante Chong R, Barrett S, Kusko R, Zeskind B, Kaufman H. | J Transl Med | 10.1186/s12967-020-02430-9 | 2020 | ||
| p-Nitrophenyl esters provide new insights and applications for the thiolase enzyme OleA. | Smith MD, Tassoulas LJ, Biernath TA, Richman JE, Aukema KG, Wackett LP. | Comput Struct Biotechnol J | 10.1016/j.csbj.2021.05.031 | 2021 | ||
| Identification of an indole biodegradation gene cluster from Providencia rettgeri and its contribution in selectively biosynthesizing Tyrian purple. | Li F, Deng H, Zhong B, Ruan B, Zhao X, Luo X. | Front Bioeng Biotechnol | 10.3389/fbioe.2022.1109929 | 2022 | ||
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| Metabolism | Biosynthesis of lipstatin. Incorporation of multiply deuterium-labeled (5Z,8Z)-tetradeca-5,8-dienoic acid and octanoic acid. | Goese M, Eisenreich W, Kupfer E, Stohler P, Weber W, Leuenberger HG, Bacher A. | J Org Chem | 10.1021/jo010230b | 2001 | |
| Enzymology | Fungal endophytes associated with Viola odorata Linn. as bioresource for pancreatic lipase inhibitors. | Katoch M, Paul A, Singh G, Sridhar SNC. | BMC Complement Altern Med | 10.1186/s12906-017-1893-y | 2017 | |
| Metabolism | Biosynthetic origin of hydrogen atoms in the lipase inhibitor lipstatin. | Goese M, Eisenreich W, Kupfer E, Weber W, Bacher A. | J Biol Chem | 10.1074/jbc.m003094200 | 2000 | |
| Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model-comparative study. | Konopelniuk VV, Goloborodko II, Ishchuk TV, Synelnyk TB, Ostapchenko LI, Spivak MY, Spivak MY, Bubnov RV. | EPMA J | 10.1007/s13167-017-0098-2 | 2017 | ||
| Production of a Novel Tetrahydroxynaphthalene (THN) Derivative from Nocardia sp. CS682 by Metabolic Engineering and Its Bioactivities. | Mishra R, Dhakal D, Han JM, Lim HN, Jung HJ, Yamaguchi T, Sohng JK. | Molecules | 10.3390/molecules24020244 | 2019 | ||
| Enzymology | Pharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules. | Zaid AN, Zohud N, E'layan B, Aburadi T, Jaradat N, Ali I, Hussein F, Ghanem M, Qaddomi A, Abu Zaaror Y. | Drug Des Devel Ther | 10.2147/dddt.s138926 | 2017 | |
| Enzymology | Kojic acid repurposing as a pancreatic lipase inhibitor and the optimization of its production from a local Aspergillus oryzae soil isolate. | El-Korany SM, Helmy OM, El-Halawany AM, Ragab YE, Zedan HH. | BMC Biotechnol | 10.1186/s12896-020-00644-9 | 2020 | |
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| In vitro biocontrol activity of halotolerant Streptomyces aureofaciens K20: A potent antagonist against Macrophomina phaseolina (Tassi) Goid. | Shrivastava P, Kumar R, Yandigeri MS. | Saudi J Biol Sci | 10.1016/j.sjbs.2015.12.004 | 2017 | ||
| Melt Amorphisation of Orlistat with Mesoporous Silica Using a Supercritical Carbon Dioxide: Effects of Pressure, Temperature, and Drug Loading Ratio and Comparison with Other Conventional Amorphisation Methods. | Park H, Cha KH, Hong SH, Abuzar SM, Ha ES, Kim JS, Kim MS, Hwang SJ. | Pharmaceutics | 10.3390/pharmaceutics12040377 | 2020 | ||
| Metabolism | In Vivo Assay Reveals Microbial OleA Thiolases Initiating Hydrocarbon and beta-Lactone Biosynthesis. | Smith MD, Robinson SL, Molomjamts M, Wackett LP. | mBio | 10.1128/mbio.00111-20 | 2020 | |
| Tracer studies with crude U-13C-lipid mixtures. Biosynthesis of the lipase inhibitor lipstatin. | Eisenreich W, Kupfer E, Weber W, Bacher A. | J Biol Chem | 10.1074/jbc.272.2.867 | 1997 | ||
| Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro. | Abeysekera WPKM, Arachchige SPG, Ratnasooriya WD. | Evid Based Complement Alternat Med | 10.1155/2017/7347219 | 2017 | ||
| Enzymology | Bioprospecting potential of halogenases from Arctic marine actinomycetes. | Liao L, Chen R, Jiang M, Tian X, Liu H, Yu Y, Fan C, Chen B. | BMC Microbiol | 10.1186/s12866-016-0662-2 | 2016 | |
| Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation. | Hochuli E, Kupfer E, Maurer R, Meister W, Mercadal Y, Schmidt K. | J Antibiot (Tokyo) | 10.7164/antibiotics.40.1086 | 1987 | ||
| Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. | Weibel EK, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H. | J Antibiot (Tokyo) | 10.7164/antibiotics.40.1081 | 1987 | ||
| Pathogenicity | Chlorophyll Derivatives from Marine Cyanobacteria with Lipid-Reducing Activities. | Freitas S, Silva NG, Sousa ML, Ribeiro T, Rosa F, Leao PN, Vasconcelos V, Reis MA, Urbatzka R. | Mar Drugs | 10.3390/md17040229 | 2019 | |
| Pathogenicity | Pancreatic lipase inhibitory gallotannins from Galla Rhois with inhibitory effects on adipocyte differentiation in 3T3-L1 cells. | Kwon OJ, Bae JS, Lee HY, Hwang JY, Lee EW, Ito H, Kim TH. | Molecules | 10.3390/molecules180910629 | 2013 | |
| Total synthesis of tetrahydrolipstatin and stereoisomers via a highly regio- and diastereoselective carbonylation of epoxyhomoallylic alcohols. | Mulzer M, Tiegs BJ, Wang Y, Coates GW, O'Doherty GA. | J Am Chem Soc | 10.1021/ja505639u | 2014 | ||
| Metabolism | Active Multienzyme Assemblies for Long-Chain Olefinic Hydrocarbon Biosynthesis. | Christenson JK, Jensen MR, Goblirsch BR, Mohamed F, Zhang W, Wilmot CM, Wackett LP. | J Bacteriol | 10.1128/jb.00890-16 | 2017 | |
| Pharmaceutical quality of nine generic orlistat products compared with Xenical(r). | Taylor PW, Arnet I, Fischer A, Simpson IN. | Obes Facts | 10.1159/000319450 | 2010 | ||
| Enzymology | Identification of a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency. | Behar DM, Basel-Vanagaite L, Glaser F, Kaplan M, Tzur S, Magal N, Eidlitz-Markus T, Haimi-Cohen Y, Sarig G, Bormans C, Shohat M, Zeharia A. | J Lipid Res | 10.1194/jlr.p041103 | 2014 | |
| Pathogenicity | beta-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit beta-Cell Apoptosis. | Dedaki C, Kokotou MG, Mouchlis VD, Limnios D, Lei X, Mu CT, Ramanadham S, Magrioti V, Dennis EA, Kokotos G. | J Med Chem | 10.1021/acs.jmedchem.8b01216 | 2019 | |
| Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin. | Borgstrom B. | Biochim Biophys Acta | 10.1016/0005-2760(88)90260-3 | 1988 | ||
| Pathogenicity | Effects of tetrahydrolipstatin, a lipase inhibitor, on absorption of fat from the intestine of the rat. | Fernandez E, Borgstrom B. | Biochim Biophys Acta | 10.1016/0005-2760(89)90107-0 | 1989 | |
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| Biochemical characterization of an alkaline and detergent-stable Lipase from Fusarium annulatum Bugnicourt strain CBS associated with olive tree dieback. | Dab A, Hasnaoui I, Mechri S, Allala F, Bouacem K, Noiriel A, Bouanane-Darenfed A, Saalaoui E, Asehraou A, Wang F, Abousalham A, Jaouadi B. | PLoS One | 10.1371/journal.pone.0286091 | 2023 | ||
| Structural Insights from Molecular Dynamics Simulations of Tryptophan 7-Halogenase and Tryptophan 5-Halogenase. | Ainsley J, Mulholland AJ, Black GW, Sparagano O, Christov CZ, Karabencheva-Christova TG. | ACS Omega | 10.1021/acsomega.8b00385 | 2018 | ||
| Enzymology | Polyphenolic Compounds and Digestive Enzymes: In Vitro Non-Covalent Interactions. | Martinez-Gonzalez AI, Diaz-Sanchez AG, Rosa LA, Vargas-Requena CL, Bustos-Jaimes I, Alvarez-Parrilla AE. | Molecules | 10.3390/molecules22040669 | 2017 | |
| Metabolism | Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis. | Goins CM, Dajnowicz S, Smith MD, Parks JM, Ronning DR. | J Biol Chem | 10.1074/jbc.ra117.001681 | 2018 | |
| Biological Properties and Bioactive Components of Allium cepa L.: Focus on Potential Benefits in the Treatment of Obesity and Related Comorbidities. | Marrelli M, Amodeo V, Statti G, Conforti F. | Molecules | 10.3390/molecules24010119 | 2018 | ||
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| Pathogenicity | Reduction of dietary fat absorption by the novel gastrointestinal lipase inhibitor cetilistat in healthy volunteers. | Bryson A, de la Motte S, Dunk C. | Br J Clin Pharmacol | 10.1111/j.1365-2125.2008.03311.x | 2009 | |
| Pathogenicity | Daesiho-Tang Is an Effective Herbal Formulation in Attenuation of Obesity in Mice through Alteration of Gene Expression and Modulation of Intestinal Microbiota. | Hussain A, Yadav MK, Bose S, Wang JH, Lim D, Song YK, Ko SG, Kim H. | PLoS One | 10.1371/journal.pone.0165483 | 2016 | |
| Screening of phospholipase A activity and its production by new actinomycete strains cultivated by solid-state fermentation. | Sutto-Ortiz P, Camacho-Ruiz MLA, Kirchmayr MR, Camacho-Ruiz RM, Mateos-Diaz JC, Noiriel A, Carriere F, Abousalham A, Rodriguez JA. | PeerJ | 10.7717/peerj.3524 | 2017 | ||
| Pathogenicity | High sensitivity of Giardia duodenalis to tetrahydrolipstatin (orlistat) in vitro. | Hahn J, Seeber F, Kolodziej H, Ignatius R, Laue M, Aebischer T, Klotz C. | PLoS One | 10.1371/journal.pone.0071597 | 2013 | |
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| Streptomyces globosus UAE1, a Potential Effective Biocontrol Agent for Black Scorch Disease in Date Palm Plantations. | Saeed EE, Sham A, Salmin Z, Abdelmowla Y, Iratni R, El-Tarabily K, AbuQamar S. | Front Microbiol | 10.3389/fmicb.2017.01455 | 2017 | ||
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| Medicinal Plants and Their Inhibitory Activities against Pancreatic Lipase: A Review. | Seyedan A, Alshawsh MA, Alshagga MA, Koosha S, Mohamed Z. | Evid Based Complement Alternat Med | 10.1155/2015/973143 | 2015 | ||
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| Asymmetric synthesis of anti-aldol segments via a nonaldol route: synthetic applications to statines and (-)-tetrahydrolipstatin. | Ghosh AK, Shurrush K, Kulkarni S. | J Org Chem | 10.1021/jo900642f | 2009 | ||
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| Phylogeny | Streptomyces indicus sp. nov., an actinomycete isolated from deep-sea sediment. | Luo Y, Xiao J, Wang Y, Xu J, Xie S, Xu J. | Int J Syst Evol Microbiol | 10.1099/ijs.0.029389-0 | 2011 | |
| Phylogeny | Streptomyces yangpuensis sp. nov., isolated from soil. | Tang B, Yu Y, Zhi X, Yang L, Cen X, Zhao G, Ding X | Int J Syst Evol Microbiol | 10.1099/ijsem.0.000861 | 2015 | |
| Phylogeny | Streptomyces amritsarensis sp. nov., exhibiting broad-spectrum antimicrobial activity. | Sharma D, Mayilraj S, Manhas RK | Antonie Van Leeuwenhoek | 10.1007/s10482-014-0151-2 | 2014 |
| #9371 | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40178 |
| #20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 ) |
| #20218 | Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 ) |
| #66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) . |
| #67770 | Japan Collection of Microorganism (JCM) ; Curators of the JCM; |
| #68379 | Automatically annotated from API Coryne . |
| #68382 | Automatically annotated from API zym . |
| #69250 | Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig . |
| #69479 | João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta . |
| #124043 | Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy . |
| #125438 | Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 ) |
| #125439 | Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 . |
| #126262 | A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 ) |
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