Streptomyces nodosus (DSM 40109, ATCC 14899, ATCC 23942)

Cell morphology

Multimedia

• @ref:	9320
  multimedia content:	DSM_40109.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40109.jpg
  caption:	Medium 252 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9320	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
9320	STARCH - MINERAL SALT - AGAR (STMS) (DSMZ Medium 252)		Medium recipe at MediaDive	Name: STARCH - MINERAL SALT - AGAR (STMS) (DSMZ Medium 252) Composition: Agar 20.0 g/l Starch 10.0 g/l (NH4)2SO4 2.0 g/l CaCO3 2.0 g/l K2HPO4 1.0 g/l MgSO4 x 7 H2O 1.0 g/l NaCl 1.0 g/l FeSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l ZnSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Compound production

Halophily

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
18536	22599 ChEBI	arabinose	-
68368	29016 ChEBI	arginine	-	hydrolysis	from API 20E
18536	62968 ChEBI	cellulose	-
68368	16947 ChEBI	citrate	-	assimilation	from API 20E
18536	28757 ChEBI	fructose	+
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
18536	17234 ChEBI	glucose	+
68368	25094 ChEBI	lysine	+	degradation	from API 20E
18536	29864 ChEBI	mannitol	+/-
18536	17268 ChEBI	myo-inositol	+/-
68368	18257 ChEBI	ornithine	+	degradation	from API 20E
18536	16634 ChEBI	raffinose	-
18536	26546 ChEBI	rhamnose	-
18536	17992 ChEBI	sucrose	-
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	+	hydrolysis	from API 20E
18536	18222 ChEBI	xylose	+

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	15688 ChEBI	acetoin		from API 20E
67770		amphotericin A
67770		amphotericin B
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68368	35581 ChEBI	indole		from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	-		from API 20E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68368	arginine dihydrolase	-	3.5.3.6	from API 20E
68368	beta-galactosidase	+	3.2.1.23	from API 20E
68368	gelatinase	+		from API 20E
68368	lysine decarboxylase	+	4.1.1.18	from API 20E
68368	ornithine decarboxylase	+	4.1.1.17	from API 20E
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68368	urease	+	3.5.1.5	from API 20E

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
66794	adipate degradation	100	2 of 2
66794	coenzyme A metabolism	100	4 of 4
66794	gallate degradation	100	5 of 5
66794	methylglyoxal degradation	100	5 of 5
66794	ppGpp biosynthesis	100	4 of 4
66794	denitrification	100	2 of 2
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	cyanate degradation	100	3 of 3
66794	valine metabolism	100	9 of 9
66794	hydrogen production	100	5 of 5
66794	enterobactin biosynthesis	100	3 of 3
66794	pentose phosphate pathway	100	11 of 11
66794	metabolism of amino sugars and derivatives	100	5 of 5
66794	starch degradation	100	10 of 10
66794	biotin biosynthesis	100	4 of 4
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	cardiolipin biosynthesis	100	7 of 7
66794	ribulose monophosphate pathway	100	2 of 2
66794	threonine metabolism	100	10 of 10
66794	suberin monomers biosynthesis	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	aspartate and asparagine metabolism	100	9 of 9
66794	acetate fermentation	100	4 of 4
66794	taurine degradation	100	1 of 1
66794	formaldehyde oxidation	100	3 of 3
66794	palmitate biosynthesis	100	22 of 22
66794	ethanol fermentation	100	2 of 2
66794	aerobactin biosynthesis	100	1 of 1
66794	ceramide biosynthesis	100	1 of 1
66794	cellulose degradation	100	5 of 5
66794	folate polyglutamylation	100	1 of 1
66794	leucine metabolism	92.31	12 of 13
66794	phenylalanine metabolism	92.31	12 of 13
66794	propionate fermentation	90	9 of 10
66794	myo-inositol biosynthesis	90	9 of 10
66794	Entner Doudoroff pathway	90	9 of 10
66794	serine metabolism	88.89	8 of 9
66794	4-hydroxymandelate degradation	88.89	8 of 9
66794	molybdenum cofactor biosynthesis	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	d-mannose degradation	88.89	8 of 9
66794	ketogluconate metabolism	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	gluconeogenesis	87.5	7 of 8
66794	flavin biosynthesis	86.67	13 of 15
66794	reductive acetyl coenzyme A pathway	85.71	6 of 7
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	citric acid cycle	85.71	12 of 14
66794	photosynthesis	85.71	12 of 14
66794	arginine metabolism	83.33	20 of 24
66794	alanine metabolism	82.76	24 of 29
66794	glutamate and glutamine metabolism	82.14	23 of 28
66794	proline metabolism	81.82	9 of 11
66794	purine metabolism	80.85	76 of 94
66794	3-chlorocatechol degradation	80	4 of 5
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	glycogen metabolism	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	heme metabolism	78.57	11 of 14
66794	NAD metabolism	77.78	14 of 18
66794	CO2 fixation in Crenarchaeota	77.78	7 of 9
66794	lipid metabolism	77.42	24 of 31
66794	methionine metabolism	76.92	20 of 26
66794	vitamin B12 metabolism	76.47	26 of 34
66794	glycolysis	76.47	13 of 17
66794	tryptophan metabolism	76.32	29 of 38
66794	dTDPLrhamnose biosynthesis	75	6 of 8
66794	toluene degradation	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	sulfopterin metabolism	75	3 of 4
66794	butanoate fermentation	75	3 of 4
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	pyrimidine metabolism	73.33	33 of 45
66794	3-phenylpropionate degradation	73.33	11 of 15
66794	metabolism of disaccharids	72.73	8 of 11
66794	histidine metabolism	72.41	21 of 29
66794	tetrahydrofolate metabolism	71.43	10 of 14
66794	aclacinomycin biosynthesis	71.43	5 of 7
66794	glutathione metabolism	71.43	10 of 14
66794	non-pathway related	71.05	27 of 38
66794	oxidative phosphorylation	70.33	64 of 91
66794	phenol degradation	70	14 of 20
66794	urea cycle	69.23	9 of 13
66794	vitamin B1 metabolism	69.23	9 of 13
66794	degradation of sugar alcohols	68.75	11 of 16
66794	octane oxidation	66.67	2 of 3
66794	sphingosine metabolism	66.67	4 of 6
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	IAA biosynthesis	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	degradation of pentoses	64.29	18 of 28
66794	d-xylose degradation	63.64	7 of 11
66794	cysteine metabolism	61.11	11 of 18
66794	arachidonate biosynthesis	60	3 of 5
66794	4-hydroxyphenylacetate degradation	60	6 of 10
66794	lysine metabolism	59.52	25 of 42
66794	degradation of aromatic, nitrogen containing compounds	58.33	7 of 12
66794	isoprenoid biosynthesis	57.69	15 of 26
66794	degradation of sugar acids	56	14 of 25
66794	daunorubicin biosynthesis	55.56	5 of 9
66794	sulfate reduction	53.85	7 of 13
66794	kanosamine biosynthesis II	50	1 of 2
66794	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
66794	androgen and estrogen metabolism	50	8 of 16
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	cyclohexanol degradation	50	2 of 4
66794	glycine metabolism	50	5 of 10
66794	phenylmercury acetate degradation	50	1 of 2
66794	methanogenesis from CO2	50	6 of 12
66794	vitamin E metabolism	50	2 of 4
66794	tyrosine metabolism	50	7 of 14
66794	quinate degradation	50	1 of 2
66794	degradation of hexoses	50	9 of 18
66794	resorcinol degradation	50	1 of 2
66794	polyamine pathway	47.83	11 of 23
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	phosphatidylethanolamine bioynthesis	46.15	6 of 13
66794	phenylpropanoid biosynthesis	46.15	6 of 13
66794	vitamin B6 metabolism	45.45	5 of 11
66794	carotenoid biosynthesis	45.45	10 of 22
66794	ascorbate metabolism	45.45	10 of 22
66794	cholesterol biosynthesis	45.45	5 of 11
66794	arachidonic acid metabolism	44.44	8 of 18
66794	nitrate assimilation	44.44	4 of 9
66794	propanol degradation	42.86	3 of 7
66794	benzoyl-CoA degradation	42.86	3 of 7
66794	coenzyme M biosynthesis	40	4 of 10
66794	vitamin K metabolism	40	2 of 5
66794	lipoate biosynthesis	40	2 of 5
66794	D-cycloserine biosynthesis	40	2 of 5
66794	carnitine metabolism	37.5	3 of 8
66794	lipid A biosynthesis	33.33	3 of 9
66794	methane metabolism	33.33	1 of 3
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	allantoin degradation	33.33	3 of 9
66794	pantothenate biosynthesis	33.33	2 of 6
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	mevalonate metabolism	28.57	2 of 7
66794	chlorophyll metabolism	27.78	5 of 18
66794	lactate fermentation	25	1 of 4
66794	CMP-KDO biosynthesis	25	1 of 4
66794	catecholamine biosynthesis	25	1 of 4

API 20E

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM870499v1 assembly for Streptomyces nodosus ATCC 14899	complete	GCA_008704995	40318.10		40318	97.17
66792	Streptomyces nodosus strain ATCC 14899	contig		40318.5		40318	79.8
66792	ASM1420503v1 assembly for Streptomyces nodosus DSM 40109	contig	GCA_014205035	40318.13	2870767688	40318	77.77
66792	ASM81954v1 assembly for Streptomyces nodosus ATCC 14899	chromosome	GCA_000819545	40318.3	2867064541	40318	66.25
66792	Streptomyces nodosus ATCC 14899	complete			2563366705	40318	17.6

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Streptomyces nodosus rrnB operon 16S ribosomal RNA, 23S ribosomal RNA, and 5S ribosomal RNA, complete sequence	AF114033	6195		40318
20218	Streptomyces nodosus rrnD operon 16S ribosomal RNA, 23S ribosomal RNA, and 5S ribosomal RNA, complete sequence	AF114034	6169		40318
20218	Streptomyces nodosus rrnE operon 16S ribosomal RNA, 23S ribosomal RNA, and 5S ribosomal RNA, complete sequence	AF114035	6174		40318
20218	Streptomyces nodosus rrnF operon 16S ribosomal RNA, 23S ribosomal RNA, and 5S ribosomal RNA, complete sequence	AF114036	6175		40318
20218	Streptomyces nodosus gene for 16S ribosomal RNA, partial sequence, strain: JCM 4656	D44288	120		40318
20218	Streptomyces nodosus gene for 16S rRNA, partial sequence, strain: NBRC 12895	AB184226	1476		40318
20218	Streptomyces nodosus strain NRRL B-2371 16S ribosomal RNA gene, partial sequence	DQ026661	1495		40318

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	First draft genome sequence data of TA4-1, the type strain of Gram-positive bacterium Streptomyces chiangmaiensis.	Yasawong M, Rosyidah A, Songngamsuk T, Phatcharaharikarn M, Ganta P, Chanthasena P, Chudapongse N, Santapan N, Srisakvarangkool W, Kerdtoob S, Nantapong N.	Data Brief	10.1016/j.dib.2024.110611	2024
	Impact of interspecific interactions on antimicrobial activity among soil bacteria.	Tyc O, van den Berg M, Gerards S, van Veen JA, Raaijmakers JM, de Boer W, Garbeva P.	Front Microbiol	10.3389/fmicb.2014.00567	2014
	Multifactorial genetic control and magnesium levels govern the production of a Streptomyces antibiotic with unusual cell density dependence.	Hindra, Elliot MA.	mSystems	10.1128/msystems.01368-23	2024
	Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides.	Guo X, Zhang J, Li X, Xiao E, Lange JD, Rienstra CM, Burke MD, Mitchell DA.	ACS Cent Sci	10.1021/acscentsci.1c00148	2021
Metabolism	Community structure and antibiotic production of Streptomyces nodosus bioreactors cultured in liquid environments.	Pereira T, Nikodinovic J, Nakazono C, Dennis GR, Barrow KD, Chuck JA.	Microb Biotechnol	10.1111/j.1751-7915.2008.00032.x	2008
	Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.	Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD.	Nature	10.1038/s41586-023-06710-4	2023
Metabolism	The in vitro characterization of polyene glycosyltransferases AmphDI and NysDI.	Zhang C, Moretti R, Jiang J, Thorson JS.	Chembiochem	10.1002/cbic.200800349	2008
	Streptomyces nodosus sp. n., the amphotericin-producing organism.	TREJO WH, BENNETT RE.	J Bacteriol	10.1128/jb.85.2.436-439.1963	1963
Metabolism	Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved conditions for expression of secondary metabolites from actinomycetes.	Zahn JA, Higgs RE, Hilton MD.	Appl Environ Microbiol	10.1128/aem.67.1.377-386.2001	2001
Metabolism	Prescreening bacterial colonies for bioactive molecules with Janus plates, a SBS standard double-faced microbial culturing system.	Sanchez-Hidalgo M, Pascual J, de la Cruz M, Martin J, Kath GS, Sigmund JM, Masurekar P, Vicente F, Genilloud O, Bills GF.	Antonie Van Leeuwenhoek	10.1007/s10482-012-9746-7	2012
	In Situ Raman Hyperspectral Analysis of Microbial Colonies for Secondary Metabolites Screening.	Suwa S, Ando M, Nakashima T, Horii S, Anai T, Takeyama H.	Anal Chem	10.1021/acs.analchem.4c02906	2024
Metabolism	In situ detection of antibiotic amphotericin B produced in Streptomyces nodosus using Raman microspectroscopy.	Miyaoka R, Hosokawa M, Ando M, Mori T, Hamaguchi HO, Takeyama H.	Mar Drugs	10.3390/md12052827	2014
	Identification of the peptide epimerase MslH responsible for d-amino acid introduction at the C-terminus of ribosomal peptides.	Feng Z, Ogasawara Y, Dairi T.	Chem Sci	10.1039/d0sc06308h	2020
	Biosynthesis of a new skyllamycin in Streptomyces nodosus: a cytochrome P450 forms an epoxide in the cinnamoyl chain.	Song Y, Amaya JA, Murarka VC, Mendez H, Hogan M, Muldoon J, Evans P, Ortin Y, Kelly SL, Lamb DC, Poulos TL, Caffrey P.	Org Biomol Chem	10.1039/d4ob00178h	2024
	Mechanism Analysis of Amphotericin B Controlling Postharvest Gray Mold in Table Grapes.	Wu Y, Wang J, Wang S, Ke Y, Ren T, Wang Y.	Foods	10.3390/foods14071260	2025
	Analysis of the effects of different nitrogen sources and calcium on the production of amphotericin by Streptomyces nodosus based on comparative transcriptome.	Huang K, Zhang B, Chen Y, Wu ZM, Liu ZQ, Zheng YG.	Biotechnol Appl Biochem	10.1002/bab.2221	2022
	Characterisation of Modular Polyketide Synthases Designed to Make Pentaene Analogues of Amphotericin B.	Song Y, Hogan M, Muldoon J, Evans P, Caffrey P.	Molecules	10.3390/molecules29061396	2024
	A real-world study based on the FAERS database evaluating adverse drug reactions in three amphotericin B lipid formulations.	Tong B, Wang J, Zhang Y, Liu Y, Wang J, Duan L, Yan Y, Sun Q, Luan Y, Yu J, Zhou C.	J Pharm Policy Pract	10.1080/20523211.2025.2514155	2025
	Acquired amphotericin B resistance attributed to a mutated ERG3 in Candidozyma auris.	Massic L, Doorley LA, Jones SJ, Richardson I, Siao DD, Siao L, Dykema P, Hua C, Schneider E, Cuomo CA, Rogers PD, Van Hooser S, Parker JE, Kelly SL, Hess D, Rybak JM, Pandori M.	Antimicrob Agents Chemother	10.1128/aac.00601-25	2025
	Antifungal Effects of the Phloroglucinol Derivative DPPG Against Pathogenic Aspergillus fumigatus.	Wang L, He J, Feng H, Li Q, Song M, Gou H, He Y, Zhu K.	Antibiotics (Basel)	10.3390/antibiotics14050499	2025
	Amphotericin B May Decrease the Serum Level of Voriconazole: A Case Report and Brief Review of Literature.	Hu Z, Zhou H.	Infect Drug Resist	10.2147/idr.s374853	2022
	Artificial Lipidation of Antifungal Proteins and Antifungal Behavior: A Case Study with Cholesterylation.	Safaat M, Uchida K, Santoso P, Sato R, Taira T, Wakabayashi R, Goto M, Kamiya N.	Chembiochem	10.1002/cbic.202401081	2025
Metabolism	Improvement of amphotericin B production by a newly isolated Streptomyces nodosus mutant.	Zhang B, Zhang HD, Zhou YT, Huang K, Liu ZQ, Zheng YG.	Biotechnol Appl Biochem	10.1002/bab.1579	2018
	Two New Lactam Derivatives from Micromelum falcatum (Lour.) Tan. with Brine Shrimp Larvae Toxicity.	Liu B, Jin X, Chen X, Wang X, Zhang W, Luo X.	Molecules	10.3390/molecules28207157	2023
	A novel pan-fungal screening platform for antifungal drug discovery: proof of principle study.	Inman R, Warris A, Bignell E.	Antimicrob Agents Chemother	10.1128/aac.01328-24	2025
	Advanced Spectroscopic and Theoretical Study and Assessment of Antimycotic Potential in a Synergistic Composition of a 1,3,4-Thiadiazole Derivative and Amphotericin B	Slusarczyk L, Murzyniec M, Gurba M, Rachwal K, Gorecki A, Hooper J, Gagos M, Matwijczuk A.	ACS Omega
Pathogenicity	Engineered biosynthesis and characterisation of disaccharide-modified 8-deoxyamphoteronolides.	Walmsley S, De Poire E, Rawlings B, Caffrey P.	Appl Microbiol Biotechnol	10.1007/s00253-016-7986-6	2017
	Liposomal amphotericin B-induced reversible ototoxicity in a patient with disseminated histoplasmosis.	Ramu R, Sharma B, Karunakara D, Paliwal P, Bansal N, Taneja RS.	Indian J Pharmacol	10.4103/0253-7613.316948	2021
Genetics	Exploiting the genome sequence of Streptomyces nodosus for enhanced antibiotic production.	Sweeney P, Murphy CD, Caffrey P.	Appl Microbiol Biotechnol	10.1007/s00253-015-7060-9	2016
	Identification of Novel Flavonoids and Ansa-Macrolides with Activities against Leishmania donovani through Natural Product Library Screening.	Phan TN, Lee H, Baek KH, No JH.	Pathogens	10.3390/pathogens13030213	2024
	Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s.	Amaya JA, Lamb DC, Kelly SL, Caffrey P, Murarka VC, Poulos TL.	J Biol Chem	10.1016/j.jbc.2022.101746	2022
	Identification of RimR2 as a positive pathway-specific regulator of rimocidin biosynthesis in Streptomyces rimosus M527.	Li H, Hu Y, Zhang Y, Ma Z, Bechthold A, Yu X.	Microb Cell Fact	10.1186/s12934-023-02039-9	2023
	Paving the way for affordable and equitable liposomal amphotericin B access worldwide.	Lee JSF, Cohen RM, Khan RA, Burry J, Casas EC, Chung HY, Costa LH, Ford N, Galvao DLN, Giron N, Jarvis JN, Mondal M, Odionyi JJ, Casas CP, Rangaraj A, Rode J, Ruffell C, Sued O, Ribeiro I.	Lancet Glob Health	10.1016/s2214-109x(24)00225-0	2024
Genetics	Nitric oxide synthase-guided genome mining identifies a cytochrome P450 enzyme for olefin nitration in bacterial specialized metabolism.	Li H, Li W, Song K, Liu Y, Zhao G, Du YL.	Synth Syst Biotechnol	10.1016/j.synbio.2024.01.005	2024
	Invasive fungal infections in critically ill children: epidemiology, risk factors and antifungal drugs.	Hon KLE, Chan VP, Leung AK, Leung KKY, Hui WF.	Drugs Context	10.7573/dic.2023-9-2	2024
	Engineered biosynthesis and characterization of disaccharide-pimaricin.	Zuo X, Qiao L, Dong Y, Jin X, Ren Z, Cui H.	Microb Cell Fact	10.1186/s12934-025-02742-9	2025
Pathogenicity	Assessment of the mutagenic, recombinogenic, and carcinogenic potential of amphotericin B in somatic cells of Drosophila melanogaster.	Saturnino RS, Machado NM, Lopes JC, Nepomuceno JC.	Drug Chem Toxicol	10.1080/01480545.2016.1188302	2018
	Amphotericin B biosynthesis in Streptomyces nodosus: quantitative analysis of metabolism via LC-MS/MS based metabolomics for rational design.	Zhang B, Zhou YT, Jiang SX, Zhang YH, Huang K, Liu ZQ, Zheng YG.	Microb Cell Fact	10.1186/s12934-020-1290-y	2020
	Anti-fungal therapy: An overview for maxillofacial surgeons in post-covid-19 fungal infections.	Datarkar A, Bhawalkar A, Daware S, Deshpande A, Walkey D.	Natl J Maxillofac Surg	10.4103/njms.njms_412_21	2022
	A Real-World Data Observational Analysis of the Impact of Liposomal Amphotericin B on Renal Function Using Machine Learning in Critically Ill Patients.	Sacanella I, Esteve-Pitarch E, Guevara-Chaux J, Berrueta J, Garcia-Martinez A, Gomez J, Casarino C, Ales F, Canadell L, Martin-Loeches I, Grau S, Candel FJ, Bodi M, Rodriguez A.	Antibiotics (Basel)	10.3390/antibiotics13080760	2024
Metabolism	Insights into the genomic and functional divergence of NAT gene family to serve microbial secondary metabolism.	Boukouvala S, Kontomina E, Olbasalis I, Patriarcheas D, Tzimotoudis D, Arvaniti K, Manolias A, Tsatiri MA, Basdani D, Zekkas S.	Sci Rep	10.1038/s41598-024-65342-4	2024
	Progress in antileishmanial drugs: Mechanisms, challenges, and prospects.	Zhang H, Yan R, Liu Y, Yu M, He Z, Xiao J, Li K, Liu G, Ning Q, Li Y.	PLoS Negl Trop Dis	10.1371/journal.pntd.0012735	2025
	Selected Gut Bacteria from Water Monitor Lizard Exhibit Effects against Pathogenic Acanthamoeba castellanii Belonging to the T4 Genotype.	Akbar N, Khan NA, Giddey AD, Soares NC, Alharbi AM, Alfahemi H, Siddiqui R.	Microorganisms	10.3390/microorganisms11041072	2023
Metabolism	The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores.	Nakagawa Y, Umegawa Y, Matsushita N, Yamamoto T, Tsuchikawa H, Hanashima S, Oishi T, Matsumori N, Murata M.	Biochemistry	10.1021/acs.biochem.6b00193	2016
	Pharmacovigilance study of amphotericin B for mucormycosis in post-COVID and non-COVID patients at a tertiary care hospital in Eastern India.	Chatterjee S, Bhattacharjee M, Hazra A, Mukhopadhyay P, Ray BK, Chatterjee S, Dubey S.	Indian J Pharmacol	10.4103/ijp.ijp_474_22	2022
	Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches.	Barreto EM, Pereira GRC, Areas IS, Fortes JM, Domingos ADS, Cabral LM, Rodrigues CR, de Souza AMT, Abrahim-Vieira BA.	J Cell Biochem	10.1002/jcb.70060	2025
Metabolism	Comparative metabolomics analysis of amphotericin B high-yield mechanism for metabolic engineering.	Zhang B, Chen Y, Jiang SX, Cai X, Huang K, Liu ZQ, Zheng YG.	Microb Cell Fact	10.1186/s12934-021-01552-z	2021
Pathogenicity	Lysine enhances the effect of amphotericin B against Candida albicans in vitro.	Zhao L, Jiang J, Zhu Z, Liao Z, Yao X, Yang Y, Cao Y, Jiang Y.	Acta Biochim Biophys Sin (Shanghai)	10.1093/abbs/gmv125	2016
	Comparing Invasive Pulmonary Aspergillosis Mortality Between Liposomal Amphotericin B and Voriconazole in Patients With Hematological Malignancy or Hematopoietic Stem Cell Transplantation.	Mahmoud E, Alzahrani M, Loutfi S, Alqahatani HY, Bosaeed M, Ahmed A, Alahmari B, Alsadi H, Ahmed M, Al Dhoayan M.	Cureus	10.7759/cureus.31762	2022
Metabolism	Transcriptional regulation and increased production of asukamycin in engineered Streptomyces nodosus subsp. asukaensis strains.	Xie P, Sheng Y, Ito T, Mahmud T.	Appl Microbiol Biotechnol	10.1007/s00253-012-4084-2	2012
	Repurposing Amphotericin B and Its Liposomal Formulation for the Treatment of Human Mpox.	Peruzzu D, Fecchi K, Venturi G, Gagliardi MC.	Int J Mol Sci	10.3390/ijms24108896	2023
	Alligamycin A, an antifungal beta-lactone spiroketal macrolide from Streptomyces iranensis.	Yang Z, Qiao Y, Strobech E, Morth JP, Walther G, Jorgensen TS, Lum KY, Peschel G, Rosenbaum MA, Previtali V, Clausen MH, Lukassen MV, Gotfredsen CH, Kurzai O, Weber T, Ding L.	Nat Commun	10.1038/s41467-024-53695-3	2024
Metabolism	Streptomyces nodosus host strains optimized for polyene glycosylation engineering.	Stephens N, Rawlings B, Caffrey P.	Biosci Biotechnol Biochem	10.1271/bbb.110673	2012
	Repurposing Amphotericin B: anti-microbial, molecular docking and molecular dynamics simulation studies suggest inhibition potential of Amphotericin B against MRSA.	Farid N, Bux K, Ali K, Bashir A, Tahir R.	BMC Chem	10.1186/s13065-023-00980-9	2023
	Effect of cholesterol and ergosterol on the antibiotic amphotericin B interactions with dipalmitoylphosphatidylcholine monolayers: X-ray reflectivity study.	Kaminski DM, Czernel G, Murphy B, Runge B, Magnussen OM, Gagos M.	Biochim Biophys Acta	10.1016/j.bbamem.2014.08.004	2014
Metabolism	Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis.	Stephens N, Rawlings B, Caffrey P.	Biosci Biotechnol Biochem	10.1271/bbb.120961	2013
	Antimicrobial activities of metabolites isolated from endophytic Aspergillus flavus of Sarcophyton ehrenbergi supported by in-silico study and NMR spectroscopy.	Singab ANB, Elkhawas YA, Al-Sayed E, Elissawy AM, Fawzy IM, Mostafa NM.	Fungal Biol Biotechnol	10.1186/s40694-023-00161-2	2023
Metabolism	Effect of starter unit availability on the spectrum of manumycin-type metabolites produced by Streptomyces nodosus ssp. asukaensis.	Pospisil S, Petrickova K, Petrickova K, Sedmera P, Halada P, Olsovska J, Petricek M.	J Appl Microbiol	10.1111/j.1365-2672.2011.05132.x	2011
	Enhanced AmB Production in Streptomyces nodosus by Fermentation Regulation and Rational Combined Feeding Strategy.	Zhang B, Zhang YH, Chen Y, Chen K, Jiang SX, Huang K, Liu ZQ, Zheng YG.	Front Bioeng Biotechnol	10.3389/fbioe.2020.00597	2020
	AmBisome® Formulations for Pediatrics: Stability, Cytotoxicity, and Cost-Effectiveness Studies.	Zuccari G, Villa C, Iurilli V, Barabino P, Zorzoli A, Marimpietri D, Caviglia D, Russo E.	Pharmaceutics	10.3390/pharmaceutics16040466	2024
Pathogenicity	Amphotericin B-copper(II) complex as a potential agent with higher antifungal activity against Candida albicans.	Chudzik B, Tracz IB, Czernel G, Fiolka MJ, Borsuk G, Gagos M, Gagos M.	Eur J Pharm Sci	10.1016/j.ejps.2013.06.007	2013
	Amphotericin B-PEG Conjugates of ZnO Nanoparticles: Enhancement Antifungal Activity with Minimal Toxicity.	Alshahrani SM, Khafagy ES, Riadi Y, Al Saqr A, Alfadhel MM, Alfadhel MM, Hegazy WAH.	Pharmaceutics	10.3390/pharmaceutics14081646	2022
	Structure and Candidate Biosynthetic Gene Cluster of a Manumycin-Type Metabolite from Salinispora pacifica.	Castro-Falcon G, Creamer KE, Chase AB, Kim MC, Sweeney D, Glukhov E, Fenical W, Jensen PR.	J Nat Prod	10.1021/acs.jnatprod.1c01117	2022
Enzymology	Commercially available lipid formulations of amphotericin b: are they bioequivalent and therapeutically equivalent?	Cifani C, Costantino S, Massi M, Berrino L.	Acta Biomed		2012
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	Synthesis and Biological Evaluation of Amphotericin B Formulations Based on Organic Salts and Ionic Liquids against Leishmania infantum.	Ferraz R, Santarem N, Santos AFM, Jacinto ML, Cordeiro-da-Silva A, Prudencio C, Noronha JP, Branco LC, Petrovski Z.	Antibiotics (Basel)	10.3390/antibiotics11121841	2022
Metabolism	Isolation and characterisation of amphotericin B analogues and truncated polyketide intermediates produced by genetic engineering of Streptomyces nodosus.	Murphy B, Anderson K, Borissow C, Caffrey P, Griffith G, Hearn J, Ibrahim O, Khan N, Lamburn N, Lee M, Pugh K, Rawlings B.	Org Biomol Chem	10.1039/b922074g	2010
	Stimulated Biosynthesis of an C10-Deoxy Heptaene NPP B2 via Regulatory Genes Overexpression in Pseudonocardia autotrophica.	Park HS, Kim HJ, Han CY, Nah HJ, Choi SS, Kim ES.	Front Microbiol	10.3389/fmicb.2020.00019	2020
	Isolation, Characterization of Pyraclostrobin Derived from Soil Actinomycete Streptomyces sp. HSN-01 and Its Antimicrobial and Anticancer Activity.	Math HH, Nayaka S, Rudrappa M, Kumar RS, Almansour AI, Perumal K, Kantli GB.	Antibiotics (Basel)	10.3390/antibiotics12071211	2023
	Enhanced Antifungal Activity of Amphotericin B Bound to Albumin: A "Trojan Horse" Effect of the Protein.	Grela E, Staczek S, Nowak M, Pawlikowska-Pawlega B, Zdybicka-Barabas A, Janik S, Cytrynska M, Grudzinski W, Gruszecki WI, Luchowski R.	J Phys Chem B	10.1021/acs.jpcb.3c01168	2023
Genetics	Comparative proteomics analysis of adult Haemonchus contortus isolates from Ovis ammon.	Liu G, Liu Q, Han Z, Wang P, Li Y.	Front Cell Infect Microbiol	10.3389/fcimb.2023.1087210	2023
Metabolism	A labile point in mutant amphotericin polyketide synthases.	Khan N, Rawlings B, Caffrey P.	Biotechnol Lett	10.1007/s10529-011-0538-3	2011
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Metabolism	Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: impact on amphotericin biosynthesis and implications for glycosylation engineering.	Nic Lochlainn L, Caffrey P.	Metab Eng	10.1016/j.ymben.2008.08.007	2009
	Amphotericin B as antiviral drug: Possible efficacy against COVID-19.	Al-Khikani FHO.	Ann Thorac Med	10.4103/atm.atm_147_20	2020
	Improvement of the Solubility Amphotericin B Using Olive Oil Nanoemulsion Coated with Chitosan for More Effective Treatment of Zoonotic Cutaneous Leishmaniasis.	Taghizadeh E, Khamesipour A, Khoee S, Jaafari MR, Hosseini SA.	Iran J Pharm Res	10.22037/ijpr.2021.115034.15162	2021
	Comparison of Efficacy of Two Different Concentrations of Intralesional Amphotericin B in the Treatment of Cutaneous Leishmaniasis; A Randomized Controlled Trial.	Goswami P, Ghiya BC, Kumar V, Rekha S, Mehta RD.	Indian Dermatol Online J	10.4103/idoj.idoj_470_18	2019
Metabolism	Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis.	Santos-Aberturas J, Payero TD, Vicente CM, Guerra SM, Canibano C, Martin JF, Aparicio JF.	Metab Eng	10.1016/j.ymben.2011.09.011	2011
Metabolism	Engineered biosynthesis of disaccharide-modified polyene macrolides.	De Poire E, Stephens N, Rawlings B, Caffrey P.	Appl Environ Microbiol	10.1128/aem.02197-13	2013
	Amphotericin B Polymer Nanoparticles Show Efficacy against Candida Species Biofilms.	Alakkad A, Stapleton P, Schlosser C, Murdan S, Odunze U, Schatzlein A, Uchegbu IF.	Pathogens	10.3390/pathogens11010073	2022
	Nystatin-like Pseudonocardia polyene B1, a novel disaccharide-containing antifungal heptaene antibiotic.	Kim HJ, Han CY, Park JS, Oh SH, Kang SH, Choi SS, Kim JM, Kwak JH, Kim ES.	Sci Rep	10.1038/s41598-018-31801-y	2018
	Penicillium nalgiovense Laxa isolated from Antarctica is a new source of the antifungal metabolite amphotericin B.	Svahn KS, Chryssanthou E, Olsen B, Bohlin L, Goransson U.	Fungal Biol Biotechnol	10.1186/s40694-014-0011-x	2015
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	Inorganic Nanoparticles: Tools to Emphasize the Janus Face of Amphotericin B.	Boudier A, Mammari N, Lamouroux E, Duval RE.	Antibiotics (Basel)	10.3390/antibiotics12101543	2023
	Genetic analysis of nystatin and amphotericin biosynthesis.	Zotchev S, Caffrey P.	Methods Enzymol	10.1016/s0076-6879(09)04611-4	2009
	Redesign of polyene macrolide glycosylation: engineered biosynthesis of 19-(O)-perosaminyl-amphoteronolide B.	Hutchinson E, Murphy B, Dunne T, Breen C, Rawlings B, Caffrey P.	Chem Biol	10.1016/j.chembiol.2010.01.007	2010
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	Safety Evaluation of Nano-Liposomal Formulation of Amphotericin B (Sina Ampholeish) in Animal Model as a Candidate for Treatment of Cutaneous Leishmaniasis.	Eskandari SE, Firooz A, Nassiri-Kashani M, Jaafari MR, Javadi A, Miramin-Mohammadi A, Valian-Keshavarz H, Khamesipour A.	J Arthropod Borne Dis	10.18502/jad.v12i3.78	2018
	An inexpensive and easy-to-make customized antibiotics mix for mycobacterium culture.	Kesarwani A, Nagpal P, Mishra A, Zaidi R, Upadhyay P.	F1000Res	10.12688/f1000research.14467.1	2018
Pathogenicity	Nematicidal Activity of Grammicin Biosynthesis Pathway Intermediates in Xylaria grammica KCTC 13121BP against Meloidogyne incognita.	Kim YJ, Duraisamy K, Jeong MH, Park SY, Kim S, Lee Y, Nguyen VT, Yu NH, Park AR, Kim JC.	Molecules	10.3390/molecules26154675	2021
	Potential Strategies to Control the Risk of Antifungal Resistance in Humans: A Comprehensive Review.	Rabaan AA, Sulaiman T, Al-Ahmed SH, Buhaliqah ZA, Buhaliqah AA, AlYuosof B, Alfaresi M, Al Fares MA, Alwarthan S, Alkathlan MS, Almaghrabi RS, Abuzaid AA, Altowaileb JA, Al Ibrahim M, AlSalman EM, Alsalman F, Alghounaim M, Bueid AS, Al-Omari A, Mohapatra RK.	Antibiotics (Basel)	10.3390/antibiotics12030608	2023
Genetics	Exploring the Potential of Antibiotic Production From Rare Actinobacteria by Whole-Genome Sequencing and Guided MS/MS Analysis.	Hu D, Sun C, Jin T, Fan G, Mok KM, Li K, Lee SM.	Front Microbiol	10.3389/fmicb.2020.01540	2020
	The proteomic response of Aspergillus fumigatus to amphotericin B (AmB) reveals the involvement of the RTA-like protein RtaA in AmB resistance.	Abou-Kandil A, Troger-Gorler S, Pschibul A, Kruger T, Rosin M, Schmidt F, Akbarimoghaddam P, Sarkar A, Cseresnyes Z, Shadkchan Y, Heinekamp T, Graler MH, Barber AE, Walther G, Figge MT, Brakhage AA, Osherov N, Kniemeyer O.	Microlife	10.1093/femsml/uqae024	2025
	Fatty Acid Composition and Metabolism in Leishmania Parasite Species: Potential Biomarkers or Drug Targets for Leishmaniasis?	Leroux M, Luquain-Costaz C, Lawton P, Azzouz-Maache S, Delton I.	Int J Mol Sci	10.3390/ijms24054702	2023
	Amphotericin B and Curcumin Co-Loaded Porous Microparticles as a Sustained Release System against Candida albicans.	Xue B, Yu Y, Peng G, Sun M, Lv P, Li X.	Molecules	10.3390/molecules27103079	2022
	Synergistic Antifungal Interaction between Pseudomonas aeruginosa LV Strain Metabolites and Biogenic Silver Nanoparticles against Candida auris.	Spoladori LFA, Andriani GM, Castro IM, Suzukawa HT, Gimenes ACR, Bartolomeu-Goncalves G, Ishida K, Nakazato G, Pinge-Filho P, Machado RRB, Nakamura CV, Andrade G, Tavares ER, Yamauchi LM, Yamada-Ogatta SF.	Antibiotics (Basel)	10.3390/antibiotics12050861	2023
	Identification and Heterologous Expression of the Kendomycin B Biosynthetic Gene Cluster from Verrucosispora sp. SCSIO 07399.	Chen J, Zhang S, Chen Y, Tian X, Gu Y, Ju J.	Mar Drugs	10.3390/md19120673	2021
Enzymology	Engineered synthesis of 7-oxo- and 15-deoxy-15-oxo-amphotericins: insights into structure-activity relationships in polyene antibiotics.	Power P, Dunne T, Murphy B, Nic Lochlainn L, Rai D, Borissow C, Rawlings B, Caffrey P.	Chem Biol	10.1016/j.chembiol.2007.11.008	2008
Enzymology	Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.	Manam RR, Teisan S, White DJ, Nicholson B, Grodberg J, Neuteboom ST, Lam KS, Mosca DA, Lloyd GK, Potts BC.	J Nat Prod	10.1021/np049725x	2005
Pathogenicity	In Silico Insights into the Mechanism of Action of Epoxy-alpha-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.	Peixoto JF, Oliveira ADS, Monteiro PQ, Goncalves-Oliveira LF, Andrade-Neto VV, Ferreira VF, Souza-Silva F, Alves CR.	Molecules	10.3390/molecules26123537	2021
	Development of a Topical Amphotericin B and Bursera graveolens Essential Oil-Loaded Gel for the Treatment of Dermal Candidiasis.	Espinoza LC, Sosa L, Granda PC, Bozal N, Diaz-Garrido N, Chulca-Torres B, Calpena AC.	Pharmaceuticals (Basel)	10.3390/ph14101033	2021
	Therapeutic Modalities in Post Kala-azar Dermal Leishmaniasis: A Systematic Review of the Effectiveness and Safety of the Treatment Options.	Datta A, Podder I, Das A, Sil A, Das NK.	Indian J Dermatol	10.4103/ijd.ijd_264_20	2021
Enzymology	Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents.	Thielen BK, Barnes AMT, Sabin AP, Huebner B, Nelson S, Wesenberg E, Hansen GT.	Mycopathologia	10.1007/s11046-018-0281-6	2019
	Antifungal Drugs.	Houst J, Spizek J, Havlicek V.	Metabolites	10.3390/metabo10030106	2020
	Biocontrol of Candida albicans by Antagonistic Microorganisms and Bioactive Compounds.	Li H, Yang J, Zhang X, Xu X, Song F, Li H.	Antibiotics (Basel)	10.3390/antibiotics11091238	2022
Metabolism	Biosynthesis of deoxyamphotericins and deoxyamphoteronolides by engineered strains of Streptomyces nodosus.	Byrne B, Carmody M, Gibson E, Rawlings B, Caffrey P.	Chem Biol	10.1016/j.chembiol.2003.12.001	2003
	High frequency transformation of the Amphotericin-producing bacterium Streptomyces nodosus.	Nikodinovic J, Barrow KD, Chuck JA.	J Microbiol Methods	10.1016/s0167-7012(03)00160-x	2003
	Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections.	Albadr AA, Tekko IA, Vora LK, Ali AA, Laverty G, Donnelly RF, Thakur RRS.	Drug Deliv Transl Res	10.1007/s13346-021-01032-2	2022
	An overview of opportunistic fungal infections associated with COVID-19.	Kangabam N, Nethravathy V.	3 Biotech	10.1007/s13205-023-03648-2	2023
	Treatment of Cryptococcal Meningitis: How Have We Got Here and Where are We Going?	Ngan NTT, Flower B, Day JN.	Drugs	10.1007/s40265-022-01757-5	2022
	Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study.	Umegawa Y, Yamamoto T, Dixit M, Funahashi K, Seo S, Nakagawa Y, Suzuki T, Matsuoka S, Tsuchikawa H, Hanashima S, Oishi T, Matsumori N, Shinoda W, Murata M.	Sci Adv	10.1126/sciadv.abo2658	2022
Metabolism	Genome-guided and mass spectrometry investigation of natural products produced by a potential new actinobacterial strain isolated from a mangrove ecosystem in Futian, Shenzhen, China.	Hu D, Gao C, Sun C, Jin T, Fan G, Mok KM, Lee SM.	Sci Rep	10.1038/s41598-018-37475-w	2019
	Combination of Posaconazole and Amphotericin B in the Treatment of Candida glabrata Biofilms.	Rodrigues CF, Alves DF, Henriques M.	Microorganisms	10.3390/microorganisms6040123	2018
	An investigation of the antileishmanial properties of semi-synthetic saponins.	Anderson O, Beckett J, Briggs CC, Natrass LA, Cranston CF, Wilkinson EJ, Owen JH, Mir Williams R, Loukaidis A, Bouillon ME, Pritchard D, Lahmann M, Baird MS, Denny PW.	RSC Med Chem	10.1039/d0md00123f	2020
	The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade.	Sakyi PO, Amewu RK, Devine RNOA, Ismaila E, Miller WA, Kwofie SK.	Nat Prod Bioprospect	10.1007/s13659-021-00311-2	2021
	Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups.	Carmody M, Murphy B, Byrne B, Power P, Rai D, Rawlings B, Caffrey P.	J Biol Chem	10.1074/jbc.m506689200	2005
Biotechnology	Fungal Infections as an Uprising Threat to Human Health: Chemosensitization of Fungal Pathogens With AFP From Aspergillus giganteus.	Dhandapani K, Sivarajan K, Ravindhiran R, Sekar JN.	Front Cell Infect Microbiol	10.3389/fcimb.2022.887971	2022
	Lipsosomal amphotericin B: a review of its properties, function, and use for treatment of cutaneous leishmaniasis.	Shirzadi MR.	Res Rep Trop Med	10.2147/rrtm.s200218	2019
	First Synthesis of DBU-Conjugated Cationic Carbohydrate Derivatives and Investigation of Their Antibacterial and Antifungal Activity.	Demeter F, Torok P, Kiss A, Kovasznai-Olah R, Szigeti ZM, Baksa V, Kovacs F, Balla N, Fenyvesi F, Varadi J, Borbas A, Herczeg M.	Int J Mol Sci	10.3390/ijms24043550	2023
	Dominant formation of a single-length channel by amphotericin B in dimyristoylphosphatidylcholine membrane evidenced by 13C-31P rotational echo double resonance.	Matsuoka S, Ikeuchi H, Matsumori N, Murata M.	Biochemistry	10.1021/bi049001k	2005
	Orally Administered Amphotericin B Nanoformulations: Physical Properties of Nanoparticle Carriers on Bioavailability and Clinical Relevance.	Fairuz S, Nair RS, Billa N.	Pharmaceutics	10.3390/pharmaceutics14091823	2022
Metabolism	Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis.	Borgos SE, Sletta H, Fjaervik E, Brautaset T, Ellingsen TE, Gulliksen OM, Zotchev SB.	Arch Microbiol	10.1007/s00203-005-0083-3	2006
	Natural products and their semi-synthetic derivatives against antimicrobial-resistant human pathogenic bacteria and fungi.	Qadri H, Haseeb Shah A, Mudasir Ahmad S, Alshehri B, Almilaibary A, Ahmad Mir M.	Saudi J Biol Sci	10.1016/j.sjbs.2022.103376	2022
	Orbital Exenteration in Rhino-Orbito-Cerebral Mucormycosis: A Prospective Analytical Study with Scoring System.	Shah K, Dave V, Bradoo R, Shinde C, Prathibha M.	Indian J Otolaryngol Head Neck Surg	10.1007/s12070-018-1293-8	2019
Metabolism	Further studies on the biosynthesis of the manumycin-type antibiotic, asukamycin, and the chemical synthesis of protoasukamycin.	Hu Y, Floss HG.	J Am Chem Soc	10.1021/ja039336+	2004
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	Analysis and manipulation of amphotericin biosynthetic genes by means of modified phage KC515 transduction techniques.	Carmody M, Byrne B, Murphy B, Breen C, Lynch S, Flood E, Finnan S, Caffrey P.	Gene	10.1016/j.gene.2004.08.006	2004
	Liposomal and Deoxycholate Amphotericin B Formulations: Effectiveness against Biofilm Infections of Candida spp.	Rodrigues CF, Henriques M.	Pathogens	10.3390/pathogens6040062	2017
Genetics	Genomewide Elucidation of Drug Resistance Mechanisms for Systemically Used Antifungal Drugs Amphotericin B, Caspofungin, and Voriconazole in the Budding Yeast.	Balkan C, Ercan I, Isik E, Sahin Akdeniz E, Balcioglu O, Kodedova M, Zimmermannova O, Dundar M, Sychrova H, Koc A.	Antimicrob Agents Chemother	10.1128/aac.02268-18	2019
	Amphotericin B Specifically Induces the Two-Component System LnrJK: Development of a Novel Whole-Cell Biosensor for the Detection of Amphotericin-Like Polyenes.	Revilla-Guarinos A, Durr F, Popp PF, Doring M, Mascher T.	Front Microbiol	10.3389/fmicb.2020.02022	2020
Metabolism	Enhancement of Antibacterial Activity of Paludifilum halophilum and Identification of N-(1-Carboxy-ethyl)-phthalamic Acid as the Main Bioactive Compound.	Frikha-Dammak D, Fakhfakh J, Belhaj D, Bouattour E, Ayadi H, Chaabouni M, Ayadi H, Maalej S.	Biomed Res Int	10.1155/2020/4805706	2020
	Isolation of Actinomycetes with Cellulolytic and Antimicrobial Activities from Soils Collected from an Urban Green Space in the Philippines.	Daquioag JEL, Penuliar GM, Penuliar GM.	Int J Microbiol	10.1155/2021/6699430	2021
	Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity.	Santos BM, Bezerra-Souza A, Aragaki S, Rodrigues E, Umehara E, Ghilardi Lago JH, Laurenti MD, Ribeiro SP, Passero LFD.	Evid Based Complement Alternat Med	10.1155/2019/8780914	2019
Metabolism	The promoter of a cold-shock-like gene has pleiotropic effects on Streptomyces antibiotic biosynthesis.	Martinez-Costa OH, Zalacain M, Holmes DJ, Malpartida F.	FEMS Microbiol Lett	10.1016/s0378-1097(03)00101-0	2003
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Enzymology	Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics.	Pippa LF, Marques MP, da Silva ACT, Vilar FC, de Haes TM, da Fonseca BAL, Martinez R, Coelho EB, Wichert-Ana L, Lanchote VL.	Front Chem	10.3389/fchem.2021.782131	2021
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Metabolism	Fungal sphingolipids: role in the regulation of virulence and potential as targets for future antifungal therapies.	Mota Fernandes C, Del Poeta M.	Expert Rev Anti Infect Ther	10.1080/14787210.2020.1792288	2020
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Pathogenicity	Adaptive Role of Cell Death in Yeast Communities Stressed with Macrolide Antifungals.	Kireeva NA, Sokolov SS, Smirnova EA, Galkina KV, Severin FF, Knorre DA.	mSphere	10.1128/msphere.00745-21	2021
Pathogenicity	Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis.	Wijnant GJ, Van Bocxlaer K, Yardley V, Harris A, Murdan S, Croft SL.	Antimicrob Agents Chemother	10.1128/aac.02009-17	2018
Genetics	Pan-Genome of the Genus Streptomyces and Prioritization of Biosynthetic Gene Clusters With Potential to Produce Antibiotic Compounds.	Caicedo-Montoya C, Manzo-Ruiz M, Rios-Estepa R.	Front Microbiol	10.3389/fmicb.2021.677558	2021
	Mining for natural product antileishmanials in a fungal extract library.	Mbekeani AJ, Jones RS, Bassas Llorens M, Elliot J, Regnault C, Barrett MP, Steele J, Kebede B, Wrigley SK, Evans L, Denny PW.	Int J Parasitol Drugs Drug Resist	10.1016/j.ijpddr.2019.05.003	2019
	Preparation, Characterization, and In Vivo Pharmacokinetic Study of the Supercritical Fluid-Processed Liposomal Amphotericin B.	Lim CB, Abuzar SM, Karn PR, Cho W, Park HJ, Cho CW, Hwang SJ.	Pharmaceutics	10.3390/pharmaceutics11110589	2019
	Preparation and Characterization of Spherical Amorphous Solid Dispersion with Amphotericin B.	Mehenni L, Lahiani-Skiba M, Ladam G, Hallouard F, Skiba M.	Pharmaceutics	10.3390/pharmaceutics10040235	2018
	Antimicrobial Activity of Lipopeptide Biosurfactants Against Foodborne Pathogen and Food Spoilage Microorganisms and Their Cytotoxicity.	Kourmentza K, Gromada X, Michael N, Degraeve C, Vanier G, Ravallec R, Coutte F, Karatzas KA, Jauregi P.	Front Microbiol	10.3389/fmicb.2020.561060	2020
	Development of a topical liposomal formulation of Amphotericin B for the treatment of cutaneous leishmaniasis.	Jaafari MR, Hatamipour M, Alavizadeh SH, Abbasi A, Saberi Z, Rafati S, Taslimi Y, Mohammadi AM, Khamesipour A.	Int J Parasitol Drugs Drug Resist	10.1016/j.ijpddr.2019.09.004	2019
Metabolism	Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes.	Lewandowska A, Soutar CP, Greenwood AI, Nimerovsky E, De Lio AM, Holler JT, Hisao GS, Khandelwal A, Zhang J, SantaMaria AM, Schwieters CD, Pogorelov TV, Burke MD, Rienstra CM.	Nat Struct Mol Biol	10.1038/s41594-021-00685-4	2021
Metabolism	Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum.	Lu W, Alanzi AR, Abugrain ME, Ito T, Mahmud T.	Appl Microbiol Biotechnol	10.1007/s00253-018-9375-9	2018
	Amphotericin B: an update.	Abu-Salah KM.	Br J Biomed Sci		1996
	Plant as an Alternative Source of Antifungals against Aspergillus Infections: A Review.	Tan LF, Yap VL, Rajagopal M, Wiart C, Selvaraja M, Leong MY, Tan PL.	Plants (Basel)	10.3390/plants11223009	2022
	A Novel Antimicrobial Peptide Sparamosin26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans.	Chen YC, Yang Y, Zhang C, Chen HY, Chen F, Wang KJ.	Front Microbiol	10.3389/fmicb.2021.746006	2021
Pathogenicity	The impact of antifungals on toll-like receptors.	Mihu MR, Pattabhi R, Nosanchuk JD.	Front Microbiol	10.3389/fmicb.2014.00099	2014
Enzymology	A gastrointestinal transit study on amphotericin B-loaded solid lipid nanoparticles in rats.	Amekyeh H, Billa N, Yuen KH, Chin SL.	AAPS PharmSciTech	10.1208/s12249-014-0279-4	2015
	To evaluate efficacy and safety of amphotericin B in two different doses in the treatment of post kala-azar dermal leishmaniasis (PKDL).	Rabi Das VN, Siddiqui NA, Pal B, Lal CS, Verma N, Kumar A, Verma RB, Kumar D, Das P, Pandey K.	PLoS One	10.1371/journal.pone.0174497	2017
Pathogenicity	Amphotericin B, an Anti-Fungal Medication, Directly Increases the Cytotoxicity of NK Cells.	Kim N, Choi JW, Park HR, Kim I, Kim HS.	Int J Mol Sci	10.3390/ijms18061262	2017
Metabolism	Investigating the bifunctionality of cyclizing and "classical" 5-aminolevulinate synthases.	Liu J, Kaganjo J, Zhang W, Zeilstra-Ryalls J.	Protein Sci	10.1002/pro.3324	2018
Enzymology	Assessing the Safety, Tolerability, Pharmacokinetics, and Biodistribution of Novel Oral Formulations of Amphotericin B following Single- and Multiple-Dose Administration to Beagle Dogs.	Wasan KM, Wasan EK, Hnik P.	Antimicrob Agents Chemother	10.1128/aac.01111-20	2020
Pathogenicity	Candida albicans cell wall as a target of action for the protein-carbohydrate fraction from coelomic fluid of Dendrobaena veneta.	Fiolka MJ, Mieszawska S, Czaplewska P, Szymanska A, Stepnik K, Sofinska-Chmiel W, Buchwald T, Lewtak K.	Sci Rep	10.1038/s41598-020-73044-w	2020
Metabolism	A Macrosphelide as the Unexpected Product of a Pleurotus ostreatus Strain-Mediated Biotransformation of Halolactones Containing the gem-Dimethylcyclohexane Ring. Part 1.	Winska K, Maczka W, Grabarczyk M, Sugimoto K, Matsuya Y, Szumny A, Szumny A, Aniol M.	Molecules	10.3390/molecules21070859	2016
	Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches.	Ordonez-Robles M, Santos-Beneit F, Martin JF.	Antibiotics (Basel)	10.3390/antibiotics7020039	2018
	Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis.	Martinez-Burgo Y, Santos-Aberturas J, Rodriguez-Garcia A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P.	Front Microbiol	10.3389/fmicb.2019.00580	2019
	Emerging Antifungal Targets and Strategies.	Ivanov M, Ciric A, Stojkovic D.	Int J Mol Sci	10.3390/ijms23052756	2022
Metabolism	Development of an intergeneric conjugal transfer system for xinaomycins-producing Streptomyces noursei Xinao-4.	Sun FH, Luo D, Shu D, Zhong J, Tan H.	Int J Mol Sci	10.3390/ijms150712217	2014
Metabolism	Biochemical and genetic insights into asukamycin biosynthesis.	Rui Z, Petrickova K, Petrickova K, Skanta F, Pospisil S, Yang Y, Chen CY, Tsai SF, Floss HG, Petricek M, Yu TW.	J Biol Chem	10.1074/jbc.m110.128850	2010
Metabolism	Occurrence of two 5-aminolevulinate biosynthetic pathways in Streptomyces nodosus subsp. asukaensis is linked with the production of asukamycin.	Petricek M, Petrickova K, Petrickova K, Havlicek L, Felsberg J.	J Bacteriol	10.1128/jb.01919-05	2006
Metabolism	Unusual and Highly Bioactive Sesterterpenes Synthesized by Pleurotus ostreatus during Coculture with Trametes robiniophila Murr.	Shen XT, Mo XH, Zhu LP, Tan LL, Du FY, Wang QW, Zhou YM, Yuan XJ, Qiao B, Yang S.	Appl Environ Microbiol	10.1128/aem.00293-19	2019
	Synthesis of a highly water-soluble derivative of amphotericin B with attenuated proinflammatory activity.	Adediran SA, Day TP, Sil D, Kimbrell MR, Warshakoon HJ, Malladi SS, David SA.	Mol Pharm	10.1021/mp9001602	2009
	Microorganisms as a Potential Source of Molecules to Control Trypanosomatid Diseases.	Chan-Bacab MJ, Reyes-Estebanez MM, Camacho-Chab JC, Ortega-Morales BO.	Molecules	10.3390/molecules26051388	2021
	Biosynthetic studies of amphotericins, candicidin and nystatin by means of mutation.	Liu YT.	Proc Natl Sci Counc Repub China B		1984
	Lipid effects on expulsion rate of amphotericin B from solid lipid nanoparticles.	Tan SW, Billa N.	AAPS PharmSciTech	10.1208/s12249-013-0056-9	2014
Metabolism	Is the second sodium pump electrogenic?	Thomas LE, Rocafull MA, Del Castillo JR.	Biomed Res Int	10.1155/2013/698674	2013
	Factors affecting the production of amphotericin A.	Liu YT, Wu WL, Chiang MH, Hu SJ.	Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi		1987
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	Sixty years of Amphotericin B: An Overview of the Main Antifungal Agent Used to Treat Invasive Fungal Infections.	Cavassin FB, Bau-Carneiro JL, Vilas-Boas RR, Queiroz-Telles F.	Infect Dis Ther	10.1007/s40121-020-00382-7	2021
	Improved antifungal activity of amphotericin B-loaded TPGS-b-(PCL-ran-PGA) nanoparticles.	Tang X, Jiao R, Xie C, Xu L, Huo Z, Dai J, Qian Y, Xu W, Hou W, Wang J, Liang Y.	Int J Clin Exp Med		2015
Metabolism	The Viscoelastic Properties of the Fungal Cell Wall Allow Traffic of AmBisome as Intact Liposome Vesicles.	Walker L, Sood P, Lenardon MD, Milne G, Olson J, Jensen G, Wolf J, Casadevall A, Adler-Moore J, Gow NAR.	mBio	10.1128/mbio.02383-17	2018
Metabolism	Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling alpha-substituent stereochemistry.	Zheng J, Piasecki SK, Keatinge-Clay AT.	ACS Chem Biol	10.1021/cb400161g	2013
Pathogenicity	Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis.	Forrester S, Siefert K, Ashwin H, Brown N, Zelmar A, James S, Lagos D, Timmis J, Chatterjee M, Mottram JC, Croft SL, Kaye PM.	Wellcome Open Res	10.12688/wellcomeopenres.15606.1	2019
Metabolism	A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis.	Zhang W, Bolla ML, Kahne D, Walsh CT.	J Am Chem Soc	10.1021/ja1002845	2010
Pathogenicity	Isolation, phylogenetic analysis and anti-infective activity screening of marine sponge-associated actinomycetes.	Abdelmohsen UR, Pimentel-Elardo SM, Hanora A, Radwan M, Abou-El-Ela SH, Ahmed S, Hentschel U.	Mar Drugs	10.3390/md8030399	2010
	Recent progress in the study of the interactions of amphotericin B with cholesterol and ergosterol in lipid environments.	Kaminski DM.	Eur Biophys J	10.1007/s00249-014-0983-8	2014
	Sterol targeting drugs reveal life cycle stage-specific differences in trypanosome lipid rafts.	Sharma AI, Olson CL, Mamede JI, Gazos-Lopes F, Epting CL, Almeida IC, Engman DM.	Sci Rep	10.1038/s41598-017-08770-9	2017
	Identification and analysis of the paulomycin biosynthetic gene cluster and titer improvement of the paulomycins in Streptomyces paulus NRRL 8115.	Li J, Xie Z, Wang M, Ai G, Chen Y.	PLoS One	10.1371/journal.pone.0120542	2015
	An Overview of Drug Resistance in Protozoal Diseases.	Capela R, Moreira R, Lopes F.	Int J Mol Sci	10.3390/ijms20225748	2019
Genetics	Genome Analysis of Two Pseudonocardia Phylotypes Associated with Acromyrmex Leafcutter Ants Reveals Their Biosynthetic Potential.	Holmes NA, Innocent TM, Heine D, Bassam MA, Worsley SF, Trottmann F, Patrick EH, Yu DW, Murrell JC, Schiott M, Wilkinson B, Boomsma JJ, Hutchings MI.	Front Microbiol	10.3389/fmicb.2016.02073	2016
Metabolism	Coordinative Modulation of Chlorothricin Biosynthesis by Binding of the Glycosylated Intermediates and End Product to a Responsive Regulator ChlF1.	Li Y, Li J, Tian Z, Xu Y, Zhang J, Liu W, Tan H.	J Biol Chem	10.1074/jbc.m115.695874	2016
Pathogenicity	The Effect of Ursolic Acid on Leishmania (Leishmania) amazonensis Is Related to Programed Cell Death and Presents Therapeutic Potential in Experimental Cutaneous Leishmaniasis.	Yamamoto ES, Campos BL, Jesus JA, Laurenti MD, Ribeiro SP, Kallas EG, Rafael-Fernandes M, Santos-Gomes G, Silva MS, Sessa DP, Lago JH, Levy D, Passero LF.	PLoS One	10.1371/journal.pone.0144946	2015
Phylogeny	Delivery strategies of amphotericin B for invasive fungal infections.	Wang X, Mohammad IS, Fan L, Zhao Z, Nurunnabi M, Sallam MA, Wu J, Chen Z, Yin L, He W.	Acta Pharm Sin B	10.1016/j.apsb.2021.04.010	2021
	Sporotrichosis: an overview and therapeutic options.	Mahajan VK.	Dermatol Res Pract	10.1155/2014/272376	2014
Metabolism	Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.	Santos-Aberturas J, Vicente CM, Guerra SM, Payero TD, Martin JF, Aparicio JF.	J Biol Chem	10.1074/jbc.m110.182428	2011
Metabolism	Propionibacterium jensenii produces the polyene pigment granadaene and has hemolytic properties similar to those of Streptococcus agalactiae.	Vanberg C, Lutnaes BF, Langsrud T, Nes IF, Holo H.	Appl Environ Microbiol	10.1128/aem.00545-07	2007
Pathogenicity	Effect of amphotericin B on larval growth of Echinococcus multilocularis.	Reuter S, Merkle M, Brehm K, Kern P, Manfras B.	Antimicrob Agents Chemother	10.1128/aac.47.2.620-625.2003	2003
Metabolism	RNase III-dependent expression of the rpsO-pnp operon of Streptomyces coelicolor.	Gatewood ML, Bralley P, Jones GH.	J Bacteriol	10.1128/jb.00452-11	2011
	Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications.	Haro-Reyes T, Diaz-Peralta L, Galvan-Hernandez A, Rodriguez-Lopez A, Rodriguez-Fragoso L, Ortega-Blake I.	Membranes (Basel)	10.3390/membranes12070681	2022
	Integrative gene cloning and expression system for Streptomyces sp. US 24 and Streptomyces sp. TN 58 bioactive molecule producing strains.	Sioud S, Aigle B, Karray-Rebai I, Smaoui S, Bejar S, Mellouli L.	J Biomed Biotechnol	10.1155/2009/464986	2009
Pathogenicity	Characterization of plant-derived saponin natural products against Candida albicans.	Coleman JJ, Okoli I, Tegos GP, Holson EB, Wagner FF, Hamblin MR, Mylonakis E.	ACS Chem Biol	10.1021/cb900243b	2010
Metabolism	Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.	Mendes MV, Anton N, Martin JF, Aparicio JF.	Biochem J	10.1042/bj20040490	2005
Enzymology	Succession of microbial communities during hot composting as detected by PCR-single-strand-conformation polymorphism-based genetic profiles of small-subunit rRNA genes.	Peters S, Koschinsky S, Schwieger F, Tebbe CC.	Appl Environ Microbiol	10.1128/aem.66.3.930-936.2000	2000
	It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug.	Mesa-Arango AC, Scorzoni L, Zaragoza O.	Front Microbiol	10.3389/fmicb.2012.00286	2012
Metabolism	Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis.	Jenke-Kodama H, Borner T, Dittmann E.	PLoS Comput Biol	10.1371/journal.pcbi.0020132	2006
Metabolism	Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.	Nedal A, Sletta H, Brautaset T, Borgos SE, Sekurova ON, Ellingsen TE, Zotchev SB.	Appl Environ Microbiol	10.1128/aem.01122-07	2007
Enzymology	Cloning of S-adenosyl-L-methionine:C-24-Delta-sterol-methyltransferase (ERG6) from Leishmania donovani and characterization of mRNAs in wild-type and amphotericin B-Resistant promastigotes.	Pourshafie M, Morand S, Virion A, Rakotomanga M, Dupuy C, Loiseau PM.	Antimicrob Agents Chemother	10.1128/aac.48.7.2409-2414.2004	2004
Pathogenicity	Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani.	Purkait B, Kumar A, Nandi N, Sardar AH, Das S, Kumar S, Pandey K, Ravidas V, Kumar M, De T, Singh D, Das P.	Antimicrob Agents Chemother	10.1128/aac.00030-11	2012
Metabolism	Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin.	Sletta H, Borgos SE, Bruheim P, Sekurova ON, Grasdalen H, Aune R, Ellingsen TE, Zotchev SB.	Antimicrob Agents Chemother	10.1128/aac.49.11.4576-4583.2005	2005
Pathogenicity	Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B.	Iman M, Huang Z, Szoka FC, Jaafari MR.	Int J Pharm	10.1016/j.ijpharm.2011.01.044	2011
Metabolism	Biosynthesis of chloro-beta-hydroxytyrosine, a nonproteinogenic amino acid of the peptidic backbone of glycopeptide antibiotics.	Puk O, Bischoff D, Kittel C, Pelzer S, Weist S, Stegmann E, Sussmuth RD, Wohlleben W.	J Bacteriol	10.1128/jb.186.18.6093-6100.2004	2004
	FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast.	Smukalla S, Caldara M, Pochet N, Beauvais A, Guadagnini S, Yan C, Vinces MD, Jansen A, Prevost MC, Latge JP, Fink GR, Foster KR, Verstrepen KJ.	Cell	10.1016/j.cell.2008.09.037	2008
	Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.	Kwon-Chung KJ, Fraser JA, Doering TL, Wang Z, Janbon G, Idnurm A, Bahn YS.	Cold Spring Harb Perspect Med	10.1101/cshperspect.a019760	2014
	The oxazolomycin family: a review of current knowledge.	Oleksak P, Gonda J, Nepovimova E, Kuca K, Musilek K.	RSC Adv	10.1039/d0ra08396h	2020
	Brazilian guidelines for the management of candidiasis - a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical.	Colombo AL, Guimaraes T, Camargo LF, Richtmann R, Queiroz-Telles Fd, Salles MJ, Cunha CA, Yasuda MA, Moretti ML, Nucci M.	Braz J Infect Dis	10.1016/j.bjid.2013.02.001	2013
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Biotechnology	Enhancing the production of amphotericin B by Strepyomyces nodosus in a 50-ton bioreactor based on comparative genomic analysis.	Huang K, Zhang B, Chen Y, Wu ZM, Liu ZQ, Zheng YG	3 Biotech	10.1007/s13205-021-02844-2	2021
Transcriptome	Comparative Transcriptome Analysis of Streptomyces nodosus Mutant With a High-Yield Amphotericin B.	Huang K, Zhang B, Chen Y, Liu ZQ, Zheng YG	Front Bioeng Biotechnol	10.3389/fbioe.2020.621431	2021
Metabolism	Enhanced amphotericin B production by genetically engineered Streptomyces nodosus.	Huang K, Zhang B, Shen ZY, Cai X, Liu ZQ, Zheng YG	Microbiol Res	10.1016/j.micres.2020.126623	2020
Enzymology	Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes.	Caffrey P, Lynch S, Flood E, Finnan S, Oliynyk M	Chem Biol	10.1016/s1074-5521(01)00046-1	2001
Transcriptome	Molecular cloning and comparative sequence analyses of rRNA operons in Streptomyces nodosus ATCC 14899.	Yap WH, Wang Y	Gene	10.1016/s0378-1119(99)00112-2	1999
Genetics	Discovery of Phloeophagus Beetles as a Source of Pseudomonas Strains That Produce Potentially New Bioactive Substances and Description of Pseudomonas bohemica sp. nov.	Saati-Santamaria Z, Lopez-Mondejar R, Jimenez-Gomez A, Diez-Mendez A, Vetrovsky T, Igual JM, Velazquez E, Kolarik M, Rivas R, Garcia-Fraile P.	Front Microbiol	10.3389/fmicb.2018.00913	2018