Streptomyces mutabilis (DSM 40169, ATCC 19789, ATCC 19919)

Name: Streptomyces mutabilis (DSM 40169, ATCC 19789, ATCC 19919)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 15418

Type strain

Culture col. no. DSM 40169 ATCC 19789 ATCC 19919 CBS 541.68 IFO 12800 14 more

NCBI tax ID(s) 67332

Special Collections DSMZ JCM JMRC

History DSMZ <- E.B. Shirling, ISP <- T.P. Preobrazhenskaya, INA JCM <-- KCC S-0400 <-- IFO 12800 <-- SAJ <-- ISP 5169 <-- T. P. Preobrazhenskaya INA B-472.

Links

Streptomyces mutabilis DSM 40169 is a bacterium that was isolated from soil.

genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 265703

MTCC 1393,ATCC 19919,ATCC 19789,IFO 12800,DSM 40169,JCM 4400,VKM Ac-1851,CBS 541.68,CBS 215.62,IMET 43509,NBRC 12800,NRRL ISP-5169,HAMBI 1069,BCRC 13715,CCRC 13715,CGMCC 4.1978

@ref 20215

Last LPSN update 2026-05-29 08:28:32

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Kitasatosporales

Family Streptomycetaceae

Genus Streptomyces

Species Streptomyces mutabilis

Full scientific name Streptomyces mutabilis (Preobrazhenskaya and Ryabova 1957) Pridham et al. 1958 (Approved Lists 1980)

Synonyms (2)

Streptomyces luteus
"Actinomyces mutabilis"

BacDive ID	Other strains from **Streptomyces mutabilis** (1)	Type strain
130714	S. mutabilis E44G, DSM 42143

Morphology

Cell morphology

@ref	Gram stain	Confidence	Motility
125439	positive	99.916
125439		97.264

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
9364	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
9364	positive	growth	28
67770	positive	growth	28

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	obligate aerobe	99.847

Spore formation

@ref	Spore formation	Confidence
125439		98.041
125438		91.416

Compound production

@ref	Compound
20216	Antibiotic agent
20216	Antifungal agent

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Soil

Isolation

@ref	Sample type	Geographic location
9364	soil	ASSR

Taxonmaps

69479

Global distribution of 16S sequence KC954557 (>99% sequence identity) for Streptomyces from Microbeatlas

Aquatic Samples	0
Soil Samples	12
Animal Samples	16
Plant Samples	0
Total Samples	28

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
9364	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
124043	ASM4243363v1 assembly for Streptomyces mutabilis JCM 4400	contig	GCA_042433635			67332	74.32
67770	ASM1464981v1 assembly for Streptomyces mutabilis JCM 4400	scaffold	GCA_014649815	67332.5	8109505794	67332	4.3

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptomyces mutabilis strain DSM 40169 16S ribosomal RNA gene, partial sequence	KC954557	1347	67332
20218	Streptomyces mutabilis strain NRRL ISP-5169 16S ribosomal RNA gene, partial sequence	EF178679	1484	67332
20218	Streptomyces olivoverticillatus gene for 16S ribosomal RNA, partial sequence, strain: JCM 4400	D44007	120	66427
20218	Streptomyces mutabilis gene for 16S ribosomal RNA, partial sequence, strain: JCM 4400	D44115	121	67332
20218	Streptomyces mutabilis gene for 16S rRNA, partial sequence, strain: NBRC 12800	AB184156	1472	67332
124043	Streptomyces mutabilis strain JCM 4400 16S ribosomal RNA gene, partial sequence.	MT760540	1341	67332
124043	Streptomyces mutabilis strain NBRC 12800(T) 16S ribosomal RNA gene, partial sequence.	MN686699	500	67332

GC content

@ref	GC-content (mol%)	Method
67770	70.7	genome sequence analysis

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM4243363v1 assembly for Streptomyces mutabilis JCM 4400
NCBI: GCA_042433635

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.85	no
125439	motility	BacteriaNetⓘ	no	97.26	no
125439	gram_stain	BacteriaNetⓘ	positive	99.92	no
125439	spore_formation	BacteriaNetⓘ	yes	98.04	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptomyces mutabilis strain JCM 4400
PATRIC: 67332.5

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	85.86	no
125438	anaerobic	anaerobicⓘ	no	97.89	no
125438	spore-forming	spore-formingⓘ	yes	91.42	no
125438	aerobic	aerobicⓘ	yes	88.45	no
125438	thermophilic	thermophileⓘ	no	94.50	no
125438	flagellated	motile2+ⓘ	no	86.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Partner choice and fidelity stabilize coevolution in a Cretaceous-age defensive symbiosis.	Kaltenpoth M, Roeser-Mueller K, Koehler S, Peterson A, Nechitaylo TY, Stubblefield JW, Herzner G, Seger J, Strohm E.	Proc Natl Acad Sci U S A	10.1073/pnas.1400457111	2014
	Screening for genes coding for putative antitumor compounds, antimicrobial and enzymatic activities from haloalkalitolerant and haloalkaliphilic bacteria strains of Algerian Sahara Soils.	Selama O, Amos GC, Djenane Z, Borsetto C, Laidi RF, Porter D, Nateche F, Wellington EM, Hacene H.	Biomed Res Int	10.1155/2014/317524	2014
	Chitinase from Streptomyces mutabilis as an Effective Eco-friendly Biocontrol Agent.	Rajendran K, Krishnamoorthy M, Karuppiah K, Ethiraj K, Sekar S.	Appl Biochem Biotechnol	10.1007/s12010-023-04489-8	2024
Cultivation	Efficient Plant Growth-Promoting (PGP) Native Actinomycetes-Formulated Consortia Mode and Assessed Shelf Life Using Low-Cost Dynamic Media.	Moorthy TS, Kannan R, Thiruvengadam R, Kadaikunnan S, Khaled JM, Venkidasamy B, Thiruvengadam M.	J Microbiol Biotechnol	10.4014/jmb.2409.09040	2025
	Screening for chitin degrading bacteria in the environment of Saudi Arabia and characterization of the most potent chitinase from Streptomyces variabilis Am1.	Kotb E, Alabdalall AH, Alghamdi AI, Ababutain IM, Aldakeel SA, Al-Zuwaid SK, Algarudi BM, Algarudi SM, Ahmed AA, Albarrag AM.	Sci Rep	10.1038/s41598-023-38876-2	2023
	Consortia of Streptomyces spp. triggers defense/PAMP genes during the interaction of Groundnut bud necrosis orthotospovirus in tomato.	Dev ASR, Harish S, Karthikeyan G, Nivedha M, Sangeetha C.	3 Biotech	10.1007/s13205-024-04030-6	2024
Phylogeny	Isolation and Characterization of Antagonistic Activity of Some Streptomycetes and their Specific Actinophages from Soil.	El-Masry SS, El-Dougdoug KA, Othman BA, Mohamed SH, S Sadik A.	Pak J Biol Sci	10.3923/pjbs.2021.516.526	2021
Phylogeny	Reclassification of 15 Streptomyces species as synonyms of Streptomyces albogriseolus, Streptomyces althioticus, Streptomyces anthocyanicus, Streptomyces calvus, Streptomyces griseoincarnatus, Streptomyces mutabilis, Streptomyces pilosus or Streptomyces rochei.	Komaki H.	Int J Syst Evol Microbiol	10.1099/ijsem.0.004718	2019
	Construction and application of a "superplasmid" for enhanced production of antibiotics.	Liu Q, Lin Q, Li X, Ali M, He J.	Appl Microbiol Biotechnol	10.1007/s00253-019-10283-6	2020
	N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp. MII.	Hamed A, Abdel-Razek AS, Frese M, Wibberg D, El-Haddad AF, Ibrahim TMA, Kalinowski J, Sewald N, Shaaban M.	Z Naturforsch C J Biosci	10.1515/znc-2017-0140	2018
	Biocontrol and plant growth promoting properties of Streptomyces mutabilis strain IA1 isolated from a Saharan soil on wheat seedlings and visualization of its niches of colonization	Toumatia O, Compant S, Yekkour A, Goudjal Y, Sabaou N, Mathieu F, Sessitsch A, Zitouni A.	S Afr J Bot	10.1016/j.sajb.2016.03.020	2016
	Draft Genome Sequence of Streptomyces mutabilis TRM45540, Isolated from a Hypersaline Soil Sample.	Luo X, Wan C, Zhang L.	Genome Announc	10.1128/genomea.01465-15	2015
	Metabolite profiling and in-silico studies show multiple effects of insecticidal actinobacterium on Spodoptera littoralis.	Diab MK, Mead HM, Khedr MA, Nafie MS, Abu-Elsaoud AM, El-Shatoury SA.	Sci Rep	10.1038/s41598-024-53096-y	2024
	The Roles of Plant-Growth-Promoting Rhizobacteria (PGPR)-Based Biostimulants for Agricultural Production Systems.	Sun W, Shahrajabian MH, Soleymani A.	Plants (Basel)	10.3390/plants13050613	2024
Phylogeny	Marine Actinobacteria: Screening for Predation Leads to the Discovery of Potential New Drugs against Multidrug-Resistant Bacteria.	Ibrahimi M, Korichi W, Hafidi M, Lemee L, Ouhdouch Y, Loqman S.	Antibiotics (Basel)	10.3390/antibiotics9020091	2020
	Isolation and evaluation of Qatari soil rhizobacteria for antagonistic potential against phytopathogens and growth promotion in tomato plants.	BiBi A, Bibi S, Al-Ghouti MA, Abu-Dieyeh MH.	Sci Rep	10.1038/s41598-023-49304-w	2023
	Insights into the Variation in Bioactivities of Closely Related Streptomyces Strains from Marine Sediments of the Visayan Sea against ESKAPE and Ovarian Cancer.	Sabido EM, Tenebro CP, Trono DJVL, Vicera CVB, Leonida SFL, Maybay JJWB, Reyes-Salarda R, Amago DS, Aguadera AMV, Octaviano MC, Saludes JP, Dalisay DS.	Mar Drugs	10.3390/md19080441	2021
	Generation of a high quality library of bioactive filamentous actinomycetes from extreme biomes using a culture-based bioprospecting strategy.	Swiecimska M, Golinska P, Goodfellow M.	Front Microbiol	10.3389/fmicb.2022.1054384	2022
	Diversity, mechanisms and beneficial features of phosphate-solubilizing Streptomyces in sustainable agriculture: A review.	Chouyia FE, Ventorino V, Pepe O.	Front Plant Sci	10.3389/fpls.2022.1035358	2022
	Bioprospecting of desert actinobacteria with special emphases on griseoviridin, mitomycin C and a new bacterial metabolite producing Streptomyces sp. PU-KB10-4.	Saleem M, Hassan A, Li F, Lu Q, Ponomareva LV, Parkin S, Sun C, Thorson JS, Shaaban KA, Sajid I.	BMC Microbiol	10.1186/s12866-023-02770-8	2023
Pathogenicity	Anti-tuberculous activity of treponemycin produced by a streptomyces strain MS-6-6 isolated from Saudi Arabia.	Yassien MA, Abdallah HM, El-Halawany AM, Jiman-Fatani AA.	Molecules	10.3390/molecules20022576	2015
	Complete root specimen of plants grown in soil-filled root box: sampling, measuring, and staining method.	Koyama T, Murakami S, Karasawa T, Ejiri M, Shiono K.	Plant Methods	10.1186/s13007-021-00798-3	2021
Pathogenicity	Antimicrobial compounds from marine actinomycetes.	Wang C, Lu Y, Cao S.	Arch Pharm Res	10.1007/s12272-020-01251-0	2020
Genetics	Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C.	Crnovcic I, Ruckert C, Semsary S, Lang M, Kalinowski J, Keller U.	Adv Appl Bioinform Chem	10.2147/aabc.s117707	2017
Metabolism	A Bioactive Fraction from Streptomyces sp. Enhances Maize Tolerance against Drought Stress.	Warrad M, Hassan YM, Mohamed MSM, Hagagy N, Al-Maghrabi OA, Selim S, Saleh AM, AbdElgawad H.	J Microbiol Biotechnol	10.4014/jmb.2003.03034	2020
Phylogeny	Screening of Rhizospheric Actinomycetes for Various In-vitro and In-vivo Plant Growth Promoting (PGP) Traits and for Agroactive Compounds.	Anwar S, Ali B, Sajid I.	Front Microbiol	10.3389/fmicb.2016.01334	2016
	Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.	Almuhayawi MS, Mohamed MSM, Abdel-Mawgoud M, Selim S, Al Jaouni SK, AbdElgawad H.	Biology (Basel)	10.3390/biology10030235	2021
Phylogeny	Multiple strain analysis of Streptomyces species from Philippine marine sediments reveals intraspecies heterogeneity in antibiotic activities.	Tenebro CP, Trono DJVL, Vicera CVB, Sabido EM, Ysulat JA, Macaspac AJM, Tampus KA, Fabrigar TAP, Saludes JP, Dalisay DS.	Sci Rep	10.1038/s41598-021-96886-4	2021
Metabolism	2-Epimutalomycin and 28-epimutalomycin, two new polyether antibiotics from Streptomyces mutabilis. Derivatization of mutalomycin and the structure elucidation of two minor metabolites.	Fehr T, Kuhn M, Loosli HR, Ponelle M, Boelsterli JJ, Walkinshaw MD.	J Antibiot (Tokyo)	10.7164/antibiotics.42.897	1989
Metabolism	Formation of tomatine in tomato plants infected with Streptomyces species and treated with herbicides, correlated with reduction of Pseudomonas solanacearum and Fusarium oxysporum f. sp. lycopersici.	El-Raheem A, El-Shanshoury R, El-Sououd SM, Awadalla OA, El-Bandy NB.	Acta Microbiol Pol		1995
Metabolism	Laccases: structure, function, and potential application in water bioremediation.	Arregui L, Ayala M, Gomez-Gil X, Gutierrez-Soto G, Hernandez-Luna CE, Herrera de Los Santos M, Levin L, Rojo-Dominguez A, Romero-Martinez D, Saparrat MCN, Trujillo-Roldan MA, Valdez-Cruz NA.	Microb Cell Fact	10.1186/s12934-019-1248-0	2019
Metabolism	Functional Characterization of a Ketoreductase-Encoding Gene med-ORF12 Involved in the Formation of a Stereospecific Pyran Ring during the Biosynthesis of an Antitumor Antibiotic Medermycin.	He Q, Li L, Yang T, Li R, Li A.	PLoS One	10.1371/journal.pone.0132431	2015
	Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound.	Karthik L, Kumar G, Keswani T, Bhattacharyya A, Chandar SS, Bhaskara Rao KV.	PLoS One	10.1371/journal.pone.0090972	2014
Phylogeny	Activity of 2,4-Di-tert-butylphenol produced by a strain of Streptomyces mutabilis isolated from a Saharan soil against Candida albicans and other pathogenic fungi.	Belghit S, Driche EH, Bijani C, Zitouni A, Sabaou N, Badji B, Mathieu F	J Mycol Med	10.1016/j.mycmed.2016.03.001	2016
Phylogeny	Antifungal properties of an actinomycin D-producing strain, Streptomyces sp. IA1, isolated from a Saharan soil.	Toumatia O, Yekkour A, Goudjal Y, Riba A, Coppel Y, Mathieu F, Sabaou N, Zitouni A	J Basic Microbiol	10.1002/jobm.201400202	2014
Phylogeny	Biocontrol of Rhizoctonia solani damping-off and promotion of tomato plant growth by endophytic actinomycetes isolated from native plants of Algerian Sahara.	Goudjal Y, Toumatia O, Yekkour A, Sabaou N, Mathieu F, Zitouni A	Microbiol Res	10.1016/j.micres.2013.06.014	2013
Phylogeny	Streptomyces mayonensis sp. nov., isolated from the volcanic soils of Mt. Mayon, Philippines.	Aguilar GM, Oliveros KMP, Rosana ARR, Opulencia RB, Raymundo AK.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006900	2025
	Streptomyces argyrophyllae sp. nov., isolated from the rhizosphere soil of Cathaya argyrophylla.	Mo P, Zhou F, Luo X, Zhang Y, Deng A, Xie P, Wang Y.	Arch Microbiol	10.1007/s00203-023-03668-9	2023
Phylogeny	Streptomyces luteus sp. nov., an actinomycete isolated from soil.	Luo XX, Kai L, Wang Y, Wan CX, Zhang LL	Int J Syst Evol Microbiol	10.1099/ijsem.0.001611	2017

References

#9364	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40169
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20216	Curators of the JMRC: Jena Microbial Resource Collection (JMRC):
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptomyces mutabilis (DSM 40169, ATCC 19789, ATCC 19919)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Compound production

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_042433635

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

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