Lactobacillus helveticus (CCUG 50205, NCIMB 14005, LMG 22464)

Name: Lactobacillus helveticus (CCUG 50205, NCIMB 14005, LMG 22464)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 153568

Type strain

Culture col. no. CCUG 50205 NCIMB 14005 LMG 22464 BCRC 17499 JCM 30912

NCBI tax ID(s) 1587

Special Collections CCUG JCM

History LMG 22464 <-- F. G. Priest; Heriot-Watt Univ., UK; SA <-- H. Ikemoto; Suntory Ltd., Japan; SA.

Links

Lactobacillus helveticus CCUG 50205 is an anaerobe, mesophilic prokaryote that was isolated from Malt whisky.

anaerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 311068

LMG 22464,NCIMB 14005,CCUG 50205,BCRC 17499,CCRC 17499,JCM 30912

@ref 20215

Last LPSN update 2026-02-09 11:37:10

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Lactobacillaceae

Genus Lactobacillus

Species Lactobacillus helveticus

Full scientific name Lactobacillus helveticus (Orla-Jensen 1919) Bergey et al. 1925 (Approved Lists 1980)

Synonyms (2)

Lactobacillus suntoryeus
"Thermobacterium helveticum"

BacDive ID	Other strains from **Lactobacillus helveticus** (23)	Type strain
6471	L. helveticus 12, Lh12, DSM 20075, ATCC 15009, CCUG 30139, ... (type strain)
6525	L. helveticus CBP1, DSM 3748
134852	L. helveticus CIP 76.19, ATCC 521, JCM 1003, NCDO 87, NCIMB ...
136298	L. helveticus H2, CIP 104345, ATCC 10386, NCDO 261, NCIMB ...
136299	L. helveticus J2, CIP 104346
136381	L. helveticus 5, CIP 53.165, ATCC 7995, JCM 11039
137106	L. helveticus H-80, CIP 57.15, ATCC 12046, JCM 1554, NCDO ...
137173	L. helveticus J5, CIP 104343, ATCC 10812, IFO 3809, NCDO ...
139090	L. helveticus B2, CIP 104344, NCDO 99, JCM 1004, LMG 11446, ...
139247	L. helveticus CIP 104436, ATCC 7993
154986	L. helveticus CCUG 55959
160849	L. helveticus JCM 1005, ATCC 8001, CECT 404, NCFB 103, ...
160853	L. helveticus JCM 1006, LMG 18174
160862	L. helveticus JCM 1007, ATCC 10797, LMG 11474
160865	L. helveticus JCM 1008, ATCC 8018, CECT 414, LMG 11449, ...
161004	L. helveticus JCM 1062, BCRC 14035, LMG 18182
161122	L. helveticus JCM 1103, LMG 18183
162696	L. helveticus JCM 20023, ATU L-21, IAM 1042
162913	L. helveticus JCM 20397, IAM 12090
172918	L. helveticus 61 BZ, CRBIP24.47
172919	L. helveticus 60 A, CRBIP24.54
172920	L. helveticus 60 B, CRBIP24.55
172921	L. helveticus 64 AB, CRBIP24.65

Morphology

Cell morphology

@ref	Motility	Confidence	Gram stain
125438		93.5
125438		93.772	positive

Culture and growth conditions

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
58785	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
58785	anaerobe
125439	microaerophile	92.3

Spore formation

@ref	Spore formation	Confidence
125438		91.066

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68381	40585 ChEBI	alpha-cyclodextrin	-	builds acid from	from API rID32STR
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68381	29016 ChEBI	arginine	-	hydrolysis	from API rID32STR
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
68371	17057 ChEBI	cellobiose	+	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68381	18333 ChEBI	D-arabitol	-	builds acid from	from API rID32STR
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68381	16899 ChEBI	D-mannitol	-	builds acid from	from API rID32STR
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68380	16024 ChEBI	D-mannose	+	fermentation	from API rID32A
68381	16988 ChEBI	D-ribose	-	builds acid from	from API rID32STR
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68381	16443 ChEBI	D-tagatose	-	builds acid from	from API rID32STR
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68381	28087 ChEBI	glycogen	-	builds acid from	from API rID32STR
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68381	606565 ChEBI	hippurate	-	hydrolysis	from API rID32STR
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68381	30849 ChEBI	L-arabinose	-	builds acid from	from API rID32STR
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68381	17716 ChEBI	lactose	-	builds acid from	from API rID32STR
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	-	builds acid from	from API 50CH acid
68381	17306 ChEBI	maltose	-	builds acid from	from API rID32STR
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68381	6731 ChEBI	melezitose	-	builds acid from	from API rID32STR
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68381	28053 ChEBI	melibiose	-	builds acid from	from API rID32STR
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68381	320055 ChEBI	methyl beta-D-glucopyranoside	+	builds acid from	from API rID32STR
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	+	builds acid from	from API 50CH acid
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68381	27941 ChEBI	pullulan	-	builds acid from	from API rID32STR
68381	16634 ChEBI	raffinose	-	builds acid from	from API rID32STR
68380	16634 ChEBI	raffinose	+	fermentation	from API rID32A
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	+	builds acid from	from API 50CH acid
68381	30911 ChEBI	sorbitol	-	builds acid from	from API rID32STR
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68381	17992 ChEBI	sucrose	+	builds acid from	from API rID32STR
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68381	27082 ChEBI	trehalose	-	builds acid from	from API rID32STR
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A
68381	16199 ChEBI	urea	-	hydrolysis	from API rID32STR
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68381	15688 ChEBI	acetoin		from API rID32STR
68380	35581 ChEBI	indole		from API rID32A

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68381	15688 ChEBI	acetoin	-		from API rID32STR
68380	35581 ChEBI	indole		-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68380	alanine arylamidase	+	3.4.11.2	from API rID32A
68381	Alanyl-Phenylalanyl-Proline arylamidase	+		from API rID32STR
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68381	alkaline phosphatase	-	3.1.3.1	from API rID32STR
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68381	alpha-galactosidase	-	3.2.1.22	from API rID32STR
68380	alpha-galactosidase	-	3.2.1.22	from API rID32A
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68380	alpha-glucosidase	-	3.2.1.20	from API rID32A
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68381	arginine dihydrolase	-	3.5.3.6	from API rID32STR
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68382	beta-galactosidase	+	3.2.1.23	from API zym
68381	beta-galactosidase	+	3.2.1.23	from API rID32STR
68380	beta-galactosidase	+	3.2.1.23	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68382	beta-glucosidase	+	3.2.1.21	from API zym
68381	beta-glucosidase	+	3.2.1.21	from API rID32STR
68380	beta-glucosidase	+	3.2.1.21	from API rID32A
68381	beta-glucuronidase	-	3.2.1.31	from API rID32STR
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68381	beta-mannosidase	+	3.2.1.25	from API rID32STR
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	-		from API zym
68382	esterase lipase (C 8)	-		from API zym
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	glycin arylamidase	-		from API rID32A
68381	glycyl tryptophan arylamidase	-		from API rID32STR
68380	histidine arylamidase	-		from API rID32A
68380	L-arginine arylamidase	+		from API rID32A
68382	leucine arylamidase	+	3.4.11.1	from API zym
68380	leucine arylamidase	+	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68381	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32STR
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68381	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32STR
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68380	serine arylamidase	-		from API rID32A
68382	trypsin	-	3.4.21.4	from API zym
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	-		from API rID32A
68381	urease	-	3.5.1.5	from API rID32STR
68380	urease	-	3.5.1.5	from API rID32A
68382	valine arylamidase	-		from API zym

Fatty acid profile

Metadata FA analysis

@ref

58785

Fatty acid	Percentage	ECL
C18:1 ω9c	38.9	17.769
C19:0 CYCLO ω9c	33.9	18.87
C16:0	10.8	16
C16:1 ω7c	6.1	15.819
C18:1 ω7c /12t/9t	4.6	17.824
C14:0	2.9	14
C18:0	1.8	18
C17:1 ω8c	1	16.792

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
58785	-	-	-	-	-	+	-	-	-	-	+	+	-	+	-	-	+	-	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
58785	-	-	-	-	-	-	-	-	-	-	-	+	+	+	-	-	-	-	-	-	-	-	+	-	-	+	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
58785	-	-	-	+	-	-	+	-	-	-	+	+	-	-	-	-	-	+	-	-	-	+	-	-	+	-	-	-	-

API rID32STR

@ref	ADH (Arg)	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	TAG	beta MAN	URE
58785	-	+	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	+	-	+	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Food production	#Fermented
#Engineered	#Food production	#Beverage

Isolation

@ref	Sample type	Country	Country ISO 3 Code	Continent
58785	Malt whisky
67770	Malt whisky distilleries	Japan	JPN	Asia

Taxonmaps

69479

Global distribution of 16S sequence AY445815 (>99% sequence identity) for Lactobacillus from Microbeatlas

Aquatic Samples	2250
Soil Samples	2173
Animal Samples	42256
Plant Samples	765
Total Samples	47444

Interaction and safety

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID
66792	ASM143753v1 assembly for Lactobacillus helveticus LMG 22464	scaffold	GCA_001437535	1587.32	2660237987	1587

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
67770	Lactobacillus suntoryeus 16S ribosomal RNA gene, partial sequence	AY445815	1498		1587
67770	Lactobacillus helveticus strain LMG 22464 16S-23S ribosomal RNA intergenic spacer, complete sequence	DQ123575	203		1587

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Lactobacillus helveticus LMG 22464
NCBI: GCA_001437535

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	81.00	no
125439	motility	BacteriaNetⓘ	no	68.60	no
125439	gram_stain	BacteriaNetⓘ	positive	61.20	no
125439	oxygen_tolerance	BacteriaNetⓘ	microaerophile	92.30	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Lactobacillus helveticus LMG 22464
NCBI: GCA_001437535.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	93.77	no
125438	anaerobic	anaerobicⓘ	no	57.22	yes
125438	aerobic	aerobicⓘ	no	94.50	no
125438	spore-forming	spore-formingⓘ	no	91.07	no
125438	thermophilic	thermophileⓘ	no	94.50	yes
125438	flagellated	motile2+ⓘ	no	93.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Niche-specific adaptation of Lactobacillus helveticus strains isolated from malt whisky and dairy fermentations.	Kido Y, Maeno S, Tanno H, Kichise Y, Shiwa Y, Endo A.	Microb Genom	10.1099/mgen.0.000560	2021
Genetics	Genomic Comparison of Lactobacillus helveticus Strains Highlights Probiotic Potential.	Fontana A, Falasconi I, Molinari P, Treu L, Basile A, Vezzi A, Campanaro S, Morelli L.	Front Microbiol	10.3389/fmicb.2019.01380	2019
Genetics	Genus-Wide Assessment of Antibiotic Resistance in Lactobacillus spp.	Campedelli I, Mathur H, Salvetti E, Clarke S, Rea MC, Torriani S, Ross RP, Hill C, O'Toole PW.	Appl Environ Microbiol	10.1128/aem.01738-18	2019
Phylogeny	Lactobacillus suntoryeus sp. nov., isolated from malt whisky distilleries.	Cachat E, Priest FG	Int J Syst Evol Microbiol	10.1099/ijs.0.63266-0	2005

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#58785	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 50205
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#68380	Automatically annotated from API rID32A .
#68381	Automatically annotated from API rID32STR .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Lactobacillus helveticus (CCUG 50205, NCIMB 14005, LMG 22464)

Name and taxonomic classification