Streptomyces hygroscopicus subsp. hygroscopicus (DSM 40578, ATCC 27438, CBS 773.72)

Name: Streptomyces hygroscopicus subsp. hygroscopicus (DSM 40578, ATCC 27438, CBS 773.72)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 15311

Type strain

Strain Designation M5-13184

Culture col. no. DSM 40578 ATCC 27438 CBS 773.72 DSM 41148 ETH 28553 18 more

NCBI tax ID(s) 1912 68042

Special Collections DSMZ JCM CIP Literature strains

History DSMZ <- E.B. Shirling, ISP <- J.M. McGuire, Eli Lilly Res. Labs., M5-13184 JCM <-- KCC S-0772 <-- IFO 13472 <-- SAJ <-- ISP 5578 <-- Eli Lilly & Co.; M5-13184. CIP <- 2000, IFO <- Soc. Actinomycetes, Japan (SAJ) <- Ohio Wesleyan Univ., USA: strain ISP 5578

Links

Streptomyces hygroscopicus subsp. hygroscopicus M5-13184 is an obligate aerobe, spore-forming, Gram-positive bacterium that produces antibiotic compounds.

antibiotic compound production spore-forming Gram-positive filament-shaped obligate aerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 389289

LMG 19335,ATCC 27438,CCRC 11611,DSM 40578,IFO 13472,JCM 4772,NRRL B-2387,VKM Ac-831,MTCC 1105,NRRL 2387,CIP 106840,DSM 41148,CBS 773.72,AS 4.1527,NBRC 13472,BCRC 11611,BCC 7028,KACC 20099,NBIMCC 803,NBIMCC 1154,CGMCC 4.1527,AS4.1313,CGMCC 4.2118,CGMCC 4.1313

@ref 20215

Last LPSN update 2026-05-29 08:28:30

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Kitasatosporales

Family Streptomycetaceae

Genus Streptomyces

Species Streptomyces hygroscopicus subsp. hygroscopicus

Full scientific name Streptomyces hygroscopicus subsp. hygroscopicus (Jensen 1931) Yüntsen et al. 1956 (Approved Lists 1980)

BacDive ID	Other strains from **Streptomyces hygroscopicus subsp. hygroscopicus** (13)	Type strain
15316	S. hygroscopicus subsp. hygroscopicus SF-1084, FERM-P 602, DSM 41528, ATCC 21722, ... (type strain)
16215	S. hygroscopicus subsp. hygroscopicus A10598, DSM 41524, ATCC 15166 (type strain)
15133	S. hygroscopicus subsp. hygroscopicus 9-20, DSM 40187, AS 4.1377, ATCC 23904, CBS ...
15312	S. hygroscopicus subsp. hygroscopicus BJ-311, Tresner BJ-311, K5-4, DSM 40821, ...
15313	S. hygroscopicus subsp. hygroscopicus DSM 41525, ATCC 15869, RIA 511
15318	S. hygroscopicus subsp. hygroscopicus U-442, DSM 41531, ATCC 31039, IFO 13598
15320	S. hygroscopicus subsp. hygroscopicus T-42082, FERM-P 2691, DSM 41533, ATCC 31080, ...
15322	S. hygroscopicus subsp. hygroscopicus J296-21, DSM 41535, ATCC 39150
15323	S. hygroscopicus subsp. hygroscopicus DSM 41912, NRRL 3111
16194	S. hygroscopicus subsp. hygroscopicus DSM 41460, ATCC 43692, INMI 32, NBRC 100766, ...
164937	S. hygroscopicus subsp. hygroscopicus JCM 4092, DSM 41599, IFO 16553, NBIMCC 1604, ...
164999	S. hygroscopicus subsp. hygroscopicus JCM 4712, ATCC 21589, IFO 16555, NBRC 16555
165009	S. hygroscopicus subsp. hygroscopicus JCM 4885, IFO 16556, NBRC 16556

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
125439	positive		98.692
125439			93.951
120019	positive	filament-shaped

Colony morphology

120019

Hemolysis ability0

Pigmentation

@ref	Production	Name
25185		melanin pigment

Multimedia

@ref:	9659
multimedia content:	DSM_40578.jpg
multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40578.jpg
caption:	Medium 65 28°C
intellectual property rights:	© Leibniz-Institut DSMZ
manual_annotation:	1

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
9659	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)	Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
25185	ISP 2 agar
25185	ISP 3 agar
25185	ISP 4 agar
25185	ISP 5 agar
35999	MEDIUM 116 - for Streptomyces, Nocardia, Streptosporangium and Mycobacterium chlorophenolicum		Distilled water make up to (1000.000 ml);Agar (20.000 g);Glucose (4.000g);Yeast extract (4.000 g);Malt extract (10.000 g)
120019	CIP Medium 116	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
9659	positive	growth	28
25185	positive	growth	15.0-45.0
35999	positive	growth	30
67770	positive	growth	28
120019	positive	growth	25-41
120019	negative	growth	10
120019	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
120019	obligate aerobe
125439	obligate aerobe	97.456

Spore formation

@ref	Type of spore	Spore formation	Confidence
25185	spore
125438			91.459

Compound production

9659

Compoundhygromycin

Halophily

@ref	Salt	Growth	Tested relation	Concentration
120019	NaCl	positive	growth	0-4 %
120019	NaCl		growth	6 %
120019	NaCl		growth	8 %
120019	NaCl		growth	10 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
25185	16708 ChEBI	adenine	+	degradation
25185	17057 ChEBI	cellobiose	+	assimilation
25185	15824 ChEBI	D-fructose	+	assimilation
25185	28847 ChEBI	D-fucose	+	assimilation
25185	12936 ChEBI	D-galactose	+	assimilation
25185	17634 ChEBI	D-glucose	+	assimilation
25185	16024 ChEBI	D-mannose	+	assimilation
25185	16988 ChEBI	D-ribose	+	assimilation
25185	17924 ChEBI	D-sorbitol	-	assimilation
25185	65327 ChEBI	D-xylose	+	assimilation
120019	4853 ChEBI	esculin	+	hydrolysis
25185	16235 ChEBI	guanine	+	degradation
120019	606565 ChEBI	hippurate	-	hydrolysis
25185	17368 ChEBI	hypoxanthine	+	degradation
25185	30849 ChEBI	L-arabinose	+	assimilation
25185	62345 ChEBI	L-rhamnose	+	assimilation
25185	17716 ChEBI	lactose	+	assimilation
25185	17306 ChEBI	maltose	+	assimilation
25185	29864 ChEBI	mannitol	+	assimilation
25185	6731 ChEBI	melezitose	-	assimilation
25185	17632 ChEBI	nitrate	-	reduction
120019	17632 ChEBI	nitrate	-	reduction
120019	17632 ChEBI	nitrate	-	respiration
120019	16301 ChEBI	nitrite	-	reduction
25185	16634 ChEBI	raffinose	-	assimilation
25185	17992 ChEBI	sucrose	+	assimilation
25185	53424 ChEBI	tween 20	+	degradation
25185	53426 ChEBI	tween 80	+	degradation
25185	15318 ChEBI	xanthine	-	degradation

Antibiotic resistance

@ref	Metabolite	Is sensitive	Is resistant
120019	0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)

Metabolite production

@ref	Chebi-ID	Metabolite	Production
67770	24753 ChEBI	hygromycin
120019	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test
120019	15688 ChEBI	acetoin	-
120019	17234 ChEBI	glucose		-

Enzymes

@ref	Value	Activity	Ec
120019	alcohol dehydrogenase	-	1.1.1.1
120019	amylase	-
120019	beta-galactosidase	+	3.2.1.23
120019	caseinase	+	3.4.21.50
120019	catalase	+	1.11.1.6
120019	DNase	+
120019	gamma-glutamyltransferase	+	2.3.2.2
120019	gelatinase	+/-
120019	lecithinase	-
120019	lipase	-
120019	lysine decarboxylase	-	4.1.1.18
120019	ornithine decarboxylase	-	4.1.1.17
120019	oxidase	-
120019	phenylalanine ammonia-lyase	-	4.3.1.24
120019	protease	+
120019	tryptophan deaminase	-
120019	tween esterase	+
120019	urease	+	3.5.1.5

API biotype100

@ref	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
120019	not determinedn.d.	+	+	+	+	+	-	-	-	-	+	+	+	+	-	-	+	+	+	+	+	+	-	+	-	-	-	+	-	-	-	-	+	-	+	+	-	-	+	-	-	+	+	-	+	+	-	-	+	+	+	+	-	-	+	+	+	-	+	-	+	+	+	+	-	-	-	-	-	-	-	+	-	+	+	-	+	-	-	-	+	+	-	-	-	-	-	-	+	+	+	+	+	-	+	+	-	+	+	-

Isolation, sampling and environmental information

Taxonmaps

69479

Global distribution of 16S sequence HQ244447 (>99% sequence identity) for Streptomyces from Microbeatlas

Aquatic Samples	65
Soil Samples	635
Animal Samples	94
Plant Samples	40
Total Samples	834

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
9659	1	Risk group (German classification) According to TRBA 466
120019	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	Streptomyces hygroscopicus hygroscopicus DSM 40578	complete			651716764	68042	87
67770	ASM155345v1 assembly for Streptomyces hygroscopicus subsp. hygroscopicus NBRC 13472	contig	GCA_001553455	68042.6	2724679234	68042	0

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptomyces hygroscopicus subsp. hygroscopicus strain CGMCC 4.1527 16S ribosomal RNA gene, partial sequence	HQ244447	1401	68042
20218	Streptomyces hygroscopicus subsp. hygroscopicus gene for 16S ribosomal RNA, partial sequence, strain: JCM 4772	D44349	121	68042
20218	Streptomyces hygroscopicus subsp. hygroscopicus gene for 16S rRNA, partial sequece, strain: PNK1-3	AB231803	1450	68042
20218	Streptomyces hygroscopicus subsp. hygroscopicus gene for 16S rRNA, partial sequece, strain: PNK1-5	AB231804	1451	68042
20218	Streptomyces hygroscopicus partial 16S rRNA gene, type strain NRRL 2387T	AJ391820	1465	1912
9659	Streptomyces hygroscopicus subsp. hygroscopicus gene for 16S rRNA, partial sequence, strain: NBRC 13472	AB184428	1470	68042

GC content

@ref	GC-content (mol%)	Method
25185	72	genome sequence analysis
9659	71.97	sequence analysis
67770	71.97	genome sequence analysis
67770	71.9	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM155345v1 assembly for Streptomyces hygroscopicus subsp. hygroscopicus NBRC 13472
NCBI: GCA_001553455

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	97.46	no
125439	gram_stain	BacteriaNetⓘ	positive	98.69	no
125439	spore_formation	BacteriaNetⓘ	yes	86.40	no
125439	motility	BacteriaNetⓘ	no	93.95	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptomyces hygroscopicus subsp. hygroscopicus strain NBRC 13472
PATRIC: 68042.6

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	85.77	no
125438	anaerobic	anaerobicⓘ	no	97.34	no
125438	spore-forming	spore-formingⓘ	yes	91.46	no
125438	aerobic	aerobicⓘ	yes	86.73	no
125438	thermophilic	thermophileⓘ	no	95.00	yes
125438	flagellated	motile2+ⓘ	no	89.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in Streptomyces hygroscopicus.	Lum KY, Kumar R, Yang Z, Souza LDO, Jarmusch SA, Moreira JMA, Morth JP, Ding L.	ACS Omega	10.1021/acsomega.5c03067	2025
Metabolism	d-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B.	Tang W, Guo Z, Cao Z, Wang M, Li P, Meng X, Zhao X, Xie Z, Wang W, Zhou A, Lou C, Chen Y.	Proc Natl Acad Sci U S A	10.1073/pnas.1711665115	2018
	Deciphering hygromycin B biosynthetic pathway and D-optimal design for production optimization.	Suliman M, Bishr AS, Aboshanab KM.	World J Microbiol Biotechnol	10.1007/s11274-025-04364-0	2025
	Deciphering hygromycin B biosynthetic pathway and D-optimal design for production optimization	Suliman M, Bishr AS, Aboshanab KM.	World J Microbiol Biotechnol.		2025
Phylogeny	Taxonomic Positions of a Nyuzenamide-Producer and Its Closely Related Strains.	Komaki H, Igarashi Y, Tamura T.	Microorganisms	10.3390/microorganisms10020349	2022
	Draft Genome Sequence of Streptomyces hygroscopicus subsp. hygroscopicus NBRC 16556.	Komaki H, Ichikawa N, Oguchi A, Hamada M, Tamura T, Suzuki K, Fujita N.	Genome Announc	10.1128/genomea.00139-16	2016
	Nontargeted Metabolomics of Streptomyces Sourced from Thailand Reveals the Presence of Bioactive Metabolites.	Sunghanghwa Y, Paemanee A, Do KM, Meethangdee M, Plechata M, Pathom-Aree W, Punsawad C, Morita H, Tangphatsornruang S, Kamenik Z, Jaisi A.	ACS Omega	10.1021/acsomega.5c00669	2025
Genetics	Draft genome sequence of Streptomyces sp. TP-A0867, an alchivemycin producer.	Komaki H, Ichikawa N, Oguchi A, Hamada M, Harunari E, Kodani S, Fujita N, Igarashi Y.	Stand Genomic Sci	10.1186/s40793-016-0207-1	2016
	Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.	Sarmiento-Vizcaino A, Espadas J, Martin J, Brana AF, Reyes F, Garcia LA, Blanco G.	Front Microbiol	10.3389/fmicb.2018.00773	2018
Phylogeny	Taxonomy by carbon replication. II. Examination of eight additional cultures of Streptomyces hygroscopicus.	Dietz A, Mathews J.	Appl Microbiol	10.1128/am.16.6.935-941.1968	1968
Phylogeny	Morphological spore types in the Streptomyces hygroscopicus-like complex.	Tresner HD, Backus EJ, Hayes JA.	Appl Microbiol	10.1128/am.15.3.637-639.1967	1967
	Exploring the interactions of rapamycin with target receptors in A549 cancer cells: insights from molecular docking analysis.	Ganesh SK, Devi CS.	J Cancer Res Clin Oncol	10.1007/s00432-024-06072-y	2025
Biotechnology	Formulation of cost-effective medium and optimization studies for enhanced production of rapamycin.	K Ganesh S, C SD.	Microb Cell Fact	10.1186/s12934-023-02201-3	2023
	Rapamycin and Autophagy: Potential Therapeutic Approach for Parkinson's Disease Treatment.	Goyal A, Kumari A, Verma A, Agrawal N.	CNS Neurol Disord Drug Targets	10.2174/0118715273401017250918141227	2025
	Structure and activity of a phosphinothricin N-acetyltransferase (PSPTO_3321) from Pseudomonas syringae pv. tomato DC3000.	Davies AM, Trentham D, Sutton BJ, Brown PR.	Biochem Biophys Res Commun	10.1016/j.bbrc.2025.151539	2025
	Ferroptosis induction in host rice by endophyte OsiSh-2 is necessary for mutualism and disease resistance in symbiosis.	Xiong X, Zeng J, Ning Q, Liu H, Bu Z, Zhang X, Zeng J, Zhuo R, Cui K, Qin Z, Gao Y, Liu X, Zhu Y.	Nat Commun	10.1038/s41467-024-49099-y	2024
	Validamycin A Inhibited FB₁ Biosynthesis by the Target FvNth in Fusarium verticillioides.	Zhao B, Li J, Zhou L, Liu W, Geng S, Zhao Y, Hou Z, Zhao R, Liu Y, Dong J.	J Agric Food Chem	10.1021/acs.jafc.4c02641	2024
	Structural and Biochemical Characterization of MppQ, an L-Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus.	Vuksanovic N, Melkonian TR, Serrano DA, Schwabacher AW, Silvaggi NR.	Biochemistry	10.1021/acs.biochem.3c00428	2023
	Rapamycin improves the survival of epilepsy model cells by blocking phosphorylation of mTOR base on computer simulations and cellular experiments.	Li K, Cao JF, Gong Y, Xiong L, Wu M, Qi Y, Ying X, Liu D, Ma X, Zhang X.	Neurochem Int	10.1016/j.neuint.2024.105746	2024
Genetics	Low-Toxicity and High-Efficiency Streptomyces Genome Editing Tool Based on the Miniature Type V-F CRISPR/Cas Nuclease AsCas12f1.	Hua HM, Xu JF, Huang XS, Zimin AA, Wang WF, Lu YH.	J Agric Food Chem	10.1021/acs.jafc.3c09101	2024
	Rapamycin for longevity: the pros, the cons, and future perspectives.	Roark KM, Iffland PH.	Front Aging	10.3389/fragi.2025.1628187	2025
Metabolism	Co-cultivation strategies for natural product discovery from actinomycetes: unlocking silent secondary metabolism with mycolic acid-containing bacteria.	Asamizu S.	World J Microbiol Biotechnol	10.1007/s11274-025-04406-7	2025
	Molecular determinants of the response of cancer cells towards geldanamycin and its derivatives.	Seo EJ, Khelifi D, Fayez S, Feineis D, Bringmann G, Efferth T, Dawood M.	Chem Biol Interact	10.1016/j.cbi.2023.110677	2023
	Evolution and Functional Diversification of Serine Racemase Homologs in Bacteria.	Uda K, Nishimura R, Li Y, Shimoda E, Miyamoto T, Moe LA.	J Mol Evol	10.1007/s00239-024-10231-7	2025
	Characterisation and optimisation of microbial production of transglutaminase produced by Streptoverticillium cinnamoneum.	Kolotylo V, Synowiec A, Piwowarek K, Gientka I, Kieliszek M.	Appl Microbiol Biotechnol	10.1007/s00253-025-13606-y	2025
	Comparative Metabolomics Reveals a Bifunctional Antibacterial Conjugate from Combined-Culture of Streptomyces hygroscopicus HOK021 and Tsukamurella pulmonis TP-B0596.	Asamizu S, Pramana AAC, Kawai SJ, Arakawa Y, Onaka H.	ACS Chem Biol	10.1021/acschembio.2c00585	2022
	Structure and function of the geldanamycin amide synthase from Streptomyces hygroscopicus.	Ewert W, Bartens C, Ongouta J, Holmes M, Heutling A, Kishore A, Urbansky T, Zeilinger C, Preller M, Kirschning A.	Nat Commun	10.1038/s41467-025-57013-3	2025
	Multi-omic characterisation of Streptomyces hygroscopicus NRRL 30439: detailed assessment of its secondary metabolic potential.	Barry CP, Gillane R, Talbo GH, Plan M, Palfreyman R, Haber-Stuk AK, Power J, Nielsen LK, Marcellin E.	Mol Omics	10.1039/d1mo00150g	2022
	Rapamycin reduces DNA damage of in vitro matured oocytes by promoting Rad51-mediated homologous recombination	Yang Q, Chen Y, Huang J, Tang J, Zhu L, Li J, Tong C.	Reprod Biol Endocrinol		2025
	What is the clinical evidence to support off-label rapamycin therapy in healthy adults?	Hands JM, Lustgarten MS, Frame LA, Rosen B.	Aging (Albany NY)	10.18632/aging.206300	2025
	Priming of rice seed with decoyinine enhances resistance against the brown planthopper Nilparvata lugens	Ma C, Zhang Y, Gui W, Zhang Q, Xu G, Yang G.	Crop Prot		2022
	Physiological, biochemical and proteomic insight into the response system of Streptomyces hygroscopicus OsiSh-2 to rice blast fungus toxins	Liu Y, Chen N, Gao Y, Bu Z, Niu S, Wang Y, Liu X, Zhu Y.	Appl Soil Ecol	10.1016/j.apsoil.2021.104058	2021
	Stable transgene expression and CRISPR-mediated knock-in system of a bacteria-derived antibiotic selection gene in the green alga Ulva prolifera.	Qin Z, Surnido W, Mizuta H, Uji T.	BMC Plant Biol	10.1186/s12870-025-07411-y	2025
	Mitigation of radiation injury to reproductive system of male mice by Trichostatin A.	Haritwal T, Kalra N, Agrawala PK.	Mutat Res Genet Toxicol Environ Mutagen	10.1016/j.mrgentox.2022.503522	2022
	Investigation of a Natural Antibiotic's Properties Effective against Resistant Opportunistic Pathogenic Infections.	Khassenova A, Shorabayev Y, Zhantlessova S, Baimakhanova B, Sultanova A, Yelubaeva M.	J Microbiol Biotechnol	10.4014/jmb.2409.09018	2025
	Recombinant Extracellular Cholesterol Oxidase from Nocardioides simplex.	Fokina VV, Karpov MV, Kollerov VV, Bragin EY, Epiktetov DO, Sviridov AV, Kazantsev AV, Shutov AA, Donova MV.	Biochemistry (Mosc)	10.1134/s0006297922090048	2022
	Utilization of waste glycerol for the production of biocontrol agents nigericin and niphimycin by Streptomyces hygroscopicus: bioprocess development.	Mitrovic I, Grahovac J, Hrustic J, Jokic A, Dodic J, Mihajlovic M, Grahovac M.	Environ Technol	10.1080/09593330.2021.1913241	2022
	Sirolimus modulates the erythroid differentiation of K562 cells by upregulating SHP1.	Yang Y, Tang Z, Hu Q, Yang C, Chen M, Jing H, Han B.	Ann Hematol	10.1007/s00277-025-06518-4	2025
	Nonglycosidic C-O bond formation catalyzed by a bifunctional pseudoglycosyltransferase ValL.	Guo Z, Zhang X, Zhou L, Huang Q, Kang Q, Bai L.	Synth Syst Biotechnol	10.1016/j.synbio.2025.04.007	2025
	Potential Biological Control of Endophytic Streptomyces sp. 5-4 Against Fusarium Wilt of Banana Caused by Fusarium oxysporum f. sp. cubense Tropical Race 4.	Yun T, Jing T, Zhou D, Zhang M, Zhao Y, Li K, Zang X, Zhang L, Xie J, Wang W.	Phytopathology	10.1094/phyto-11-21-0464-r	2022
	Fractions 14 and 36K of Metabolite Extract Streptomyces hygroscopicus subsp. Hygroscopicus Have Antimalarial Activities Against Plasmodium berghei in vitro.	Fitri LE, Endharti AT, Abidah HY, Khotimah ARH, Endrawati H.	Infect Drug Resist	10.2147/idr.s400538	2023
	The Vital Role of ShTHIC from the Endophyte OsiSh-2 in Thiamine Biosynthesis and Blast Resistance in the OsiSh-2-Rice Symbiont.	Liu Y, Qin Z, Chen N, Bu Z, Yang Y, Hu X, Zheng H, Zhu Z, Xu T, Gao Y, Niu S, Xing J, Lin J, Liu X, Zhu Y.	J Agric Food Chem	10.1021/acs.jafc.2c00776	2022
	In Silico Screening of Streptomyces sp. Metabolites Targeting P. falciparum DHODH and DPCK for Antimalarial Discovery.	Hamami SMA, Riswana FR, Fitri LE, Widodo N, Zakaria MNZ, Aththar AF, Khairi ER, Abdullah A, Prasetya DY, Fai M.	Biologics	10.2147/btt.s539147	2025
Metabolism	Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach.	Rodrigues Dos Santos Barbosa C, Feitosa Muniz D, Silvino Pereira P, Maria de Arruda Lima S, Datiane de Morais Oliveira Tintino C, Cintia Alexandrino de Souza V, Mariana Assis da Silva J, Henrique Sousa da Costa R, Cosmo Andrade Pinheiro J, Maria Lobo Soares de Matos Y, Rose Alencar Menezes I, Goncalves da Silva T, Manoella de Souza Lima G, Cristina Leal Balbino T, Pinto Siqueira-Junior J, Assis Bezerra da Cunha F, Douglas Melo Coutinho H, Relison Tintino S.	Bioorg Med Chem Lett	10.1016/j.bmcl.2021.128334	2021
	Electrical alternans of the Q-T interval and fatal arrhythmias caused by neonatal cardiac tumor: a case report.	Wang G, Ding J, Wu H, Chen Y, Deng X, Li H, Li H.	Front Cardiovasc Med	10.3389/fcvm.2025.1552916	2025
Metabolism	Rapamycin-Reactivated Lipid Catabolism in Eruca sativa Mill. Exposed to Salt Stress.	Corti E, Falsini S, Patrussi G, Bazihizina N, Gonnelli C, Papini A.	Cells	10.3390/cells14141083	2025
	Mechanistic Target of Rapamycin (mTOR) Inhibitors.	Wang D, Eisen HJ.	Handb Exp Pharmacol	10.1007/164_2021_553	2022
	Streptomyces hygroscopicus OsiSh-2-induced mitigation of Fe deficiency in rice plants.	Cao L, Gao Y, Yu J, Niu S, Zeng J, Yao Q, Wang X, Bu Z, Xu T, Liu X, Zhu Y.	Plant Physiol Biochem	10.1016/j.plaphy.2020.11.013	2021
	Nigericin exerts anticancer effects through inhibition of the SRC/STAT3/BCL-2 in osteosarcoma.	Yang Z, Xie J, Fang J, Lv M, Yang M, Deng Z, Xie Y, Cai L.	Biochem Pharmacol	10.1016/j.bcp.2022.114938	2022
	Dissecting the causal association between perturbational responses of human blood cells and ischemic stroke: A Mendelian randomization analysis.	Chen B, Chen J, Han Z, Huang X, Zhan L.	Medicine (Baltimore)	10.1097/md.0000000000044976	2025
Phylogeny	Reclassification of Streptomyces hygroscopicus subsp. glebosus and Streptomyces libani subsp. rufus as later heterotypic synonyms of Streptomyces platensis.	Komaki H, Tamura T.	Int J Syst Evol Microbiol	10.1099/ijsem.0.004279	2020
	Antimicrobial mechanisms and secondary metabolite profiles of Streptomyces hygroscopicus subsp. hygroscopicus 5-4 against banana fusarium wilt disease using metabolomics.	Yun T, Jing T, Zang X, Zhou D, Li K, Zhao Y, Wang W, Xie J.	Front Microbiol	10.3389/fmicb.2023.1159534	2023
Enzymology	Biochemical characterization of 2-phosphinomethylmalate synthase from Streptomyces hygroscopicus: A member of the DRE-TIM metallolyase superfamily.	Conte JV, Frantom PA.	Arch Biochem Biophys	10.1016/j.abb.2020.108489	2020
	Rapamycin antagonizes cadmium-induced breast cancer cell proliferation and metastasis through directly modulating ACSS2.	Liang Y, Yi L, Deng P, Wang L, Yue Y, Wang H, Tian L, Xie J, Chen M, Luo Y, Yu Z, Pi H, Zhou Z.	Ecotoxicol Environ Saf	10.1016/j.ecoenv.2021.112626	2021
	Alzheimer's Disease-Related Proteins Targeted by Secondary Metabolite Compounds from Streptomyces: A Scoping Review.	Zainuddin MS, Bhuvanendran S, Radhakrishnan AK, Azman AS.	J Alzheimers Dis Rep	10.3233/adr-230065	2023
Pathogenicity	Identification of Ascomycin against Zika virus infection through screening of natural product library.	Zhou L, Zhou J, Chen T, Chi X, Liu X, Pan S, Chen W, Wu T, Lin T, Zhang X, Li YP, Yang W.	Antiviral Res	10.1016/j.antiviral.2021.105210	2021
	Translating Antiviral Therapies to Veterinary Use: A Review of Immunomodulatory Agents for Potential Application in Aleutian Mink Diseases	Kondracki M, Zmuda A, Gryzinska M, Mazurkiewicz I, Seremak B, Furmaga J, Jakubczak A.	Animals (Basel)		2025
	Engineering regiospecific methylation of the pladienolides.	Smith ER, Al-Smadi DH, Dai Y, Khin M, Burdette JE, Duggan BM, La Clair JJ, Eustaquio AS, Burkart MD.	RSC Chem Biol	10.1039/d5cb00068h	2025
	Molecular and therapeutic insights of rapamycin: a multi-faceted drug from Streptomyces hygroscopicus.	Ganesh SK, Subathra Devi C.	Mol Biol Rep	10.1007/s11033-023-08283-x	2023
	What's in (y)our food? - Occurrence of GM-containing foods on the Nigerian market and compliance with national regulations.	Amedu J, Adediji A, Miracle N, Anthony A, Adeyemi P, Ahmed R, Atsumbe S, Costly M, Majekodunmi A, Balogun O, Akinpelu O, Borgbara K, Olufowobi O, Tahir HJ, Aroworamimo L, Asagbra A.	J Genet Eng Biotechnol	10.1016/j.jgeb.2025.100481	2025
	Nigericin-induced apoptosis in acute myeloid leukemia via mitochondrial dysfunction and oxidative stress.	Arun B, Gopinath P, Jha A, Tripathi N, Dastager SG, Hasan SK.	Oncol Res	10.32604/or.2025.062951	2025
	Rapamycin golden jubilee and still the miraculous drug: a potent immunosuppressant, antitumor, rejuvenative agent, and potential contributor in COVID-19 treatment.	Mohamed MA, Elkhateeb WA, Daba GM.	Bioresour Bioprocess	10.1186/s40643-022-00554-y	2022
	Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy.	Abdullah O, Omran Z.	Int J Mol Sci	10.3390/ijms252011293	2024
Transcriptome	Insights into the roles of exogenous phenylalanine and tyrosine in improving rapamycin production of Streptomyces rapamycinicus with transcriptome analysis.	Xu D, Wang Y, Li H, Wang B, Chai L, Feng L, Ren F, Zhao X, Zhang X.	Microb Cell Fact	10.1186/s12934-024-02632-6	2024
	A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008.	Cui L, Wei X, Wang X, Bai L, Lin S, Feng Y.	ACS Synth Biol	10.1021/acssynbio.9b00319	2020
Metabolism	Enhancement of FK520 production in Streptomyces hygroscopicus by combining traditional mutagenesis with metabolic engineering.	Yu Z, Lv H, Wu Y, Wei T, Yang S, Ju D, Chen S.	Appl Microbiol Biotechnol	10.1007/s00253-019-10192-8	2019
	Streptomyces hygroscopicus UFPEDA 3370: A valuable source of the potent cytotoxic agent nigericin and its evaluation against human colorectal cancer cells.	Garcia-Princival IMR, Princival JL, Dias da Silva E, de Arruda Lima SM, Carregosa JC, Wisniewski A, de Lucena CCO, Halwass F, Alves Franca JA, Ferreira LFGR, Hernandes MZ, Saraiva KLA, Peixoto CA, Baratte B, Robert T, Bach S, Gomes DC, Guedes Paiva PM, Marchand P, Rodrigues MDD, Goncalves da Silva T.	Chem Biol Interact	10.1016/j.cbi.2020.109316	2021
	Generation of Streptomyces hygroscopicus cell factories with enhanced ascomycin production by combined elicitation and pathway-engineering strategies.	Wang C, Wang J, Yuan J, Jiang L, Jiang X, Yang B, Zhao G, Liu B, Huang D.	Biotechnol Bioeng	10.1002/bit.27158	2019
	mTOR Inhibitors Modulate the Biological Nature of TGF-beta2-Treated or -Untreated Human Trabecular Meshwork Cells in Different Manners.	Watanabe M, Sato T, Yano T, Higashide M, Ogawa T, Nishikiori N, Furuhashi M, Ohguro H.	Biomedicines	10.3390/biomedicines12112604	2024
	Construction and application of a "superplasmid" for enhanced production of antibiotics.	Liu Q, Lin Q, Li X, Ali M, He J.	Appl Microbiol Biotechnol	10.1007/s00253-019-10283-6	2020
Biotechnology	Aspergillus awamori MH2 as a novel maltobionic acid producer: production optimization and application	Yehia S, Shetaia Y, Daba G, Mostafa F, Ali A, El-Menoufy H.	Microb Cell Fact		2025
	Dissecting the antibacterial functions of the T6SS-2 cluster in Xanthomonas oryzae for environment and plant protection.	Tan Z-M, Zheng X, Su J, Liu J-S, Liang X, Pei T-T, Dong T.	Appl Environ Microbiol	10.1128/aem.01021-25	2025
Pathogenicity	Rapamycin Responds to Alzheimer's Disease: A Potential Translational Therapy.	Hou SJ, Zhang SX, Li Y, Xu SY.	Clin Interv Aging	10.2147/cia.s429440	2023
	Exploring novel microbial metabolites and drugs for inhibiting Clostridioides difficile.	Abouelkhair AA, Seleem MN.	mSphere	10.1128/msphere.00273-24	2024
	Engineering Saccharomyces cerevisiae for growth on xylose using an oxidative pathway.	Tanaka K, Yukawa T, Bamba T, Wakiya M, Kumokita R, Jin YS, Kondo A, Hasunuma T.	Appl Microbiol Biotechnol	10.1007/s00253-025-13417-1	2025
	Antifungal activity of rapamycin on Botryosphaeria dothidea and its effect against Chinese hickory canker.	Jiang H, Rao Y, Mei L, Wang Y.	Pest Manag Sci	10.1002/ps.6035	2021
	Sirolimus alleviated intractable diarrhea of IPEX syndrome: a case report and literature review.	Ye L, Song X, Cui Y, Wu S, Wang Y, Zhang T, Weng W, Ge T.	BMC Pediatr	10.1186/s12887-024-05264-2	2024
Pathogenicity	The antifungal action mode of the rice endophyte Streptomyces hygroscopicus OsiSh-2 as a potential biocontrol agent against the rice blast pathogen.	Xu T, Cao L, Zeng J, Franco CMM, Yang Y, Hu X, Liu Y, Wang X, Gao Y, Bu Z, Shi L, Zhou G, Zhou Q, Liu X, Zhu Y.	Pestic Biochem Physiol	10.1016/j.pestbp.2019.06.015	2019
Metabolism	Characterization of XtjR8: A novel esterase with phthalate-hydrolyzing activity from a metagenomic library of lotus pond sludge.	Qiu J, Yang H, Yan Z, Shi Y, Zou D, Ding L, Shao Y, Li L, Khan U, Sun S, Xin Z.	Int J Biol Macromol	10.1016/j.ijbiomac.2020.07.317	2020
	ALIX mediates reversible gasdermin-D pore formation via the endosomal pathway to limit pyroptosis by active membrane repair.	Otchere S, Shrestha P, Parmar HN, Perry JF, Hofmeister BL, Steyn M, Kaushik RS, Hoppe AD, Thiex NW, Hanson RL, Lopez-Mosqueda J, Imre G.	Cell Death Dis	10.1038/s41419-025-07998-y	2025
	Griseolutein T from Streptomyces seoulensis, newly identified via combined-culture with Tsukamurella pulmonis, as an efficacious therapeutic agent against multidrug-resistant bacteria.	Kawai SJ, Asamizu S, Suzuki H, Onaka H, Arakawa Y, Kimura K, Ojika M.	J Antibiot (Tokyo)	10.1038/s41429-025-00846-3	2025
	Interaction of Potato Autophagy-Related StATG8 Family Proteins with Pathogen Effector and WRKY Transcription Factor in the Nucleus.	Huh SU.	Microorganisms	10.3390/microorganisms13071589	2025
	Sex-Specific Lifespan Extension and Anti-Obesogenic Effects of Salicornia europaea Extract Through Tor Signaling Modulation in Drosophila.	Tahan Zadeh N, Knop M, Ulrich LM, Bruchhaus I, Lang R, Luersen K, Rimbach G, Roeder T.	Nutrients	10.3390/nu17193065	2025
	Rapamycin as a potential intervention to promote longevity and extend healthspan in companion dogs	Ryave J, Coleman A.	J Vet Sci		2025
	Screening and Validation of Reference Genes for Normalization of qRT-PCR in Rice BLB Pathogen Xanthomonas oryzae pv. oryzae Under Tetramycin Stress.	Fang F, Miao X, Mou T, Wang Z, Guo Y, Yang Y, Gao S, Wang Z, Xu C, Yang J.	Genes (Basel)	10.3390/genes16070788	2025
Pathogenicity	Rapamycin Mitigates Corneal Damage in a Mouse Model of Alkali Burn Injury.	Bhujel B, Hur W, Lee S, Lee H, Chung HS, Kim JY.	Bioengineering (Basel)	10.3390/bioengineering12090998	2025
	The Ca²⁺-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-33.	Momota M, Nagayama M, Okude H, Ishii KJ, Ori D, Kawasaki T, Kawai T.	Biochem Biophys Res Commun	10.1016/j.bbrc.2020.07.127	2020
	Molecular docking and dynamics simulation of farnesol as a potential anticancer agent targeting mTOR pathway.	Ali T, Jan I, Ramachandran R, Bashir R, Andrabi KI, Bader GN.	In Silico Pharmacol	10.1007/s40203-024-00259-4	2024
Pathogenicity	Histones in neutrophil extracellular traps (NETs) contain oxidative post-translational modifications induced by the myeloperoxidase oxidant hypochlorous acid.	Hemmling H, Hallberg LAE, Hagglund P, Hawkins CL.	Redox Biol	10.1016/j.redox.2025.103696	2025
	An mTOR inhibitor discovery system using drug-sensitized yeast.	Breen AK, Thomas S, Beckett D, Agsalud M, Gingras G, Williams J, Wasko BM.	Geroscience	10.1007/s11357-025-01534-8	2025
	Structure of prolylrapamycin: confirmation through a revised and detailed NMR assignment study.	Mortoni A, Castelli E, Recca T, Quadrelli P.	J Antibiot (Tokyo)	10.1038/s41429-024-00714-6	2024
Enzymology	A myo-inositol dehydrogenase involved in aminocyclitol biosynthesis of hygromycin A.	Akintubosun MO, Higgins MA.	Beilstein J Org Chem	10.3762/bjoc.20.51	2024
	The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on beta-Thalassemia and Other Hemoglobinopathies.	Gambari R, Zuccato C, Cosenza LC, Zurlo M, Gasparello J, Finotti A, Gamberini MR, Prosdocimi M.	Biology (Basel)	10.3390/biology12091202	2023
	Keratosis pilaris rubra successfully treated with topical sirolimus: Report of a case and review of the literature.	Eckburg A, Kazemi T, Maguiness S.	Pediatr Dermatol	10.1111/pde.14963	2022
	Investigating blood-brain barrier penetration and neurotoxicity of natural products for central nervous system drug development.	Kato R, Zhang L, Kinatukara N, Huang R, Asthana A, Weber C, Xia M, Xu X, Shah P.	Sci Rep	10.1038/s41598-025-90888-2	2025
	Design, Optimization, Manufacture and Characterization of Milbemycin Oxime Nanoemulsions.	Li ZE, Jin YG, Hu SZ, Liu Y, Duan MH, Li SH, Sun LJ, Yang F, Yang F.	Pharmaceutics	10.3390/pharmaceutics17030289	2025
	Progress about the fibro-adipose vascular anomaly: A review.	Sun YR, Zou ML, Yuan SM.	Medicine (Baltimore)	10.1097/md.0000000000037225	2024
Metabolism	MilR2, a novel TetR family regulator involved in 5-oxomilbemycin A3/A4 biosynthesis in Streptomyces hygroscopicus.	Wei K, Wu Y, Li L, Jiang W, Hu J, Lu Y, Chen S.	Appl Microbiol Biotechnol	10.1007/s00253-018-9280-2	2018
Enzymology	Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli.	Nahhas DA, Wellner SM, Sosio M, Maffioli SI, Pisanu S, Uzzau S, Pagnozzi D, Donadio S, Olsen JE.	Open Res Eur	10.12688/openreseurope.19988.2	2025
	Effect of immobilisation on production of rapamycin by Streptomyces hygroscopicus.	Sinha R, Srivastava P.	Cell Mol Biol (Noisy-le-grand)	10.14715/cmb/2017.63.6.6	2017
Metabolism	Specific mutation of transglutaminase gene from Streptomyces hygroscopicus H197 and characterization of microbial transglutaminase.	Wan W, He D, Xue Z, Zhang Z.	J Biosci	10.1007/s12038-017-9707-4	2017
	Promising Pharmacological Interventions for Posterior Capsule Opacification: A Review.	Liu Y, Dong X, Wu B, Cheng Z, Zhang J, Wang J.	Glob Chall	10.1002/gch2.202400181	2024
	Pathway of LCK Tyrosine Kinase and mTOR Signaling in Children with T-Cell Acute Lymphoblastic Leukemia.	Rocka A, Suchcicka M, Jankowska AM, Wozniak MM, Lejman M.	Appl Clin Genet	10.2147/tacg.s494389	2024
	Functional Features of Senescent Cells and Implications for Therapy.	Kirichenko TV, Markina YV, Markin AM, Vasilyev VS, Hua H, Li D, Woo AY, Deev RV, Eremin II, Kotenko KV.	Int J Mol Sci	10.3390/ijms26115390	2025
Pathogenicity	Identification of gene signatures and potential pharmaceutical candidates linked to COVID-19-related depression based on gene expression profiles.	Chen S, Luo Y, Zhang L.	Front Pharmacol	10.3389/fphar.2025.1562774	2025
	Nigericin Induces Paraptosis-Like Cell Death Instead of Pyroptosis in Corneal Keratocytes.	Mi X, Zhou X, Zhu S, Mateus A, Backman LJ, Danielson P.	FASEB J	10.1096/fj.202500502r	2025
	Assessment of the Novel Anti-Seizure Potential of Validamycin A Using Zebrafish Epilepsy Model.	Lee E, Banik A, Lee KB, Sim SM, Kil AH, Hwang BJ, Kee Y.	Molecules	10.3390/molecules29112572	2024
	Toward (-)-Enterocin: An Improved Cuprate Barbier Protocol To Overcome Strain and Sterical Hindrance.	Rizzo A, Trauner D.	Org Lett	10.1021/acs.orglett.8b00353	2018
Phylogeny	Genome analysis-based reclassification of Streptomyces endus and Streptomyces sporocinereus as later heterotypic synonyms of Streptomyces hygroscopicus subsp. hygroscopicus.	Komaki H, Ichikawa N, Oguchi A, Hamada M, Tamura T, Fujita N, Suzuki KI.	Int J Syst Evol Microbiol	10.1099/ijsem.0.001628	2017
Metabolism	Characterization of Gel16 as a Cytochrome P450 in Geldanamycin Biosynthesis and in-silico Analysis for an Endogenous Electron Transport System.	Rimal H, Yu SC, Lee B, Hong YS, Oh TJ.	J Microbiol Biotechnol	10.4014/jmb.1809.09008	2019
Metabolism	Alkaline pH shock enhanced production of validamycin A in fermentation of Streptomyces hygroscopicus.	Jiang J, Sun YF, Tang X, He CN, Shao YL, Tang YJ, Zhou WW.	Bioresour Technol	10.1016/j.biortech.2017.10.012	2018
	Discovery of novel natural products for mosquito control.	Engdahl CS, Tikhe CV, Dimopoulos G.	Parasit Vectors	10.1186/s13071-022-05594-z	2022
	Rapamycin Reduces Carcinogenesis and Enhances Survival in Mice when Administered after Nonlethal Total-Body Irradiation.	Sowers AL, Gohain S, Edmondson EF, Choudhuri R, Krishna MC, Cook JA, Mitchell JB.	Radiat Res	10.1667/rade-24-00111.1	2024
Metabolism	Approaches towards the enhanced production of Rapamycin by Streptomyces hygroscopicus MTCC 4003 through mutagenesis and optimization of process parameters by Taguchi orthogonal array methodology.	Dutta S, Basak B, Bhunia B, Sinha A, Dey A.	World J Microbiol Biotechnol	10.1007/s11274-017-2260-3	2017
	Gene Overexpression in Streptomyces hygroscopicus Associated with DNA Amplification.	Cao G, Zhang P, Gu Y, Pang X.	Curr Microbiol	10.1007/s00284-017-1278-y	2017
	Rapamycin administration causes a decrease in muscle contractile function and systemic glucose intolerance concomitant with reduced skeletal muscle Rictor, the mTORC2 component, expression independent of energy intake in young rats.	Ato S, Oya C, Ogasawara R.	PLoS One	10.1371/journal.pone.0312859	2024
	Effect of TetR Family Transcriptional Regulator PccD on Phytosterol Metabolism of Mycolicibacterium.	Xiao P, Pan D, Li F, Liu Y, Huang Y, Zhou X, Zhang Y.	Microorganisms	10.3390/microorganisms12112349	2024
	LMT2368 (1-(4-Chlorophenyl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)urea) Negatively Regulates Inflammation by Inhibiting NLRP3 Inflammasome Activation.	Nguyen TU, Kwon SJ, Hurh S, Kale A, Cho JM, Nada H, Kim CS, Induvadana P, Park BJ, Lee K, Choi Y, Hwang JI.	Pharmaceutics	10.3390/pharmaceutics17101241	2025
	Repurposing Auranofin for Oncology and Beyond: A Brief Overview of Clinical Trials as Mono- and Combination Therapy.	Giorgini D, Chiaverini L, Viviano M, Belvedere R, Salerno S, Baglini E, Da Settimo F, Marzo T, Taliani S, Barresi E.	Pharmaceuticals (Basel)	10.3390/ph18111628	2025
	The Histone Deacetylase Inhibitor Trichostatin-A Modifies the Expression of Trichothecene Mycotoxin Regulatory Gene Tri5 in Fusarium graminearum.	Amin S, Rezaee S, Mousavi A, Zamanizadeh H.	Iran J Biotechnol	10.30498/ijb.2024.437331.3872	2024
Metabolism	Engineering the TetR-family transcriptional regulator XNR_0706 to enhance heterologous spinosad production in Streptomyces albus B4 chassis.	Cui X, Tang H, Wang W, Wei W, Wu J, Ye BC.	Synth Syst Biotechnol	10.1016/j.synbio.2024.08.008	2025
	Universal plasmids to facilitate gene deletion and gene tagging in filamentous fungi.	Qin L, Li A, Tan K, Guo S, Chen Y, Wang F, Wong KH.	Fungal Genet Biol	10.1016/j.fgb.2019.01.004	2019
	Coronary stent implantation links to the occurrence of eosinophilia and interstitial pneumonia: a case report and systematic review.	Zhang F, Wang W, Zhu Y, Mao Y, Wang T, Gao P.	BMC Pulm Med	10.1186/s12890-024-03101-x	2024
	Ire1 inhibitors attenuate Candida albicans pathogenicity and demonstrate potential for application in antifungal therapy.	Wang H, Li M, Wang Q, Zhao H, Jiang M, Cui Q, Lei D, Jia K, Wang F.	Front Microbiol	10.3389/fmicb.2025.1648467	2025
	COPI Vesicle Disruption Inhibits Mineralization via mTORC1-Mediated Autophagy.	Nie J, Ma S, Zhang Y, Yu S, Yang J, Li A, Pei D.	Int J Mol Sci	10.3390/ijms25010339	2023
	Enhancing substrate specificity of microbial transglutaminase for precise nanobody labeling.	Wang X, Xu K, Fu H, Chen Q, Zhao B, Zhao X, Zhou J.	Synth Syst Biotechnol	10.1016/j.synbio.2024.10.003	2025
Metabolism	Enhancement of rapamycin production by metabolic engineering in Streptomyces hygroscopicus based on genome-scale metabolic model.	Dang L, Liu J, Wang C, Liu H, Wen J.	J Ind Microbiol Biotechnol	10.1007/s10295-016-1880-1	2017
	Novel WYL domain-containing transcriptional activator acts in response to genotoxic stress in rapidly growing mycobacteria.	Keller LML, Flattich K, Weber-Ban E.	Commun Biol	10.1038/s42003-023-05592-6	2023
	A Combinatorial Approach of High-Throughput Genomics and Mass Proteomics for Understanding the Regulation and Expression of Secondary Metabolite Production in Actinobacteria.	Gupta V, Singhvi N.	mSystems	10.1128/msystems.00862-21	2021
	Nasolacrimal Duct Coronary Stent Recanalization (NCR): First Cadaver Experience and Its Potential as an Alternative to DCR.	Ali MJ.	Ophthalmic Plast Reconstr Surg	10.1097/iop.0000000000002381	2023
	Recent advances in microfluidic-based spectroscopic approaches for pathogen detection.	Hussain M, He X, Wang C, Wang Y, Wang J, Chen M, Kang H, Yang N, Ni X, Li J, Zhou X, Liu B.	Biomicrofluidics	10.1063/5.0204987	2024
	TOR Mediates Stress Responses Through Global Regulation of Metabolome in Plants.	Yang L, Zhang R, Zhang H, Yang Y, Fu L.	Int J Mol Sci	10.3390/ijms26052095	2025
Pathogenicity	Antioxidant Strategies to Modulate NETosis and the Release of Neutrophil Extracellular Traps during Chronic Inflammation.	Hallberg LAE, Barlous K, Hawkins CL.	Antioxidants (Basel)	10.3390/antiox12020478	2023
	ZAKalpha Induces Pyroptosis of Colonic Epithelium Via the Caspase-11/GSDMD Pathway to Aggravate Colitis.	Li S, Chen M, Zheng S, Abudourexiti W, Zhu F, Wang Z, Guo Y, Yu Z, Yang Z, Zhang L, Ding C, Gong J.	Inflammation	10.1007/s10753-025-02262-z	2025
	Control of avocado anthracnose by carposphere-associated Kosakonia cowanii VG1 for agricultural applications	Gallardo-Camarena M, Reverchon F, Mendez-Bravo A, Torres-Acosta M, Licona-Cassani C.	AMB Express		2025
	Enhancement of Acarbose Production in Actinoplanes sp. QQ-12 via Multiple Engineering Strategies.	Liu G, Liu Q, Song X, Jiao X, Zhou W, Kang Q, Bai L.	J Agric Food Chem	10.1021/acs.jafc.5c00613	2025
	Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome.	Rozario P, Pinilla M, Gorse L, Vind AC, Robinson KS, Toh GA, Firdaus MJ, Martinez JF, Kerk SK, Lin Z, Chambers JC, Bekker-Jensen S, Meunier E, Zhong F.	Proc Natl Acad Sci U S A	10.1073/pnas.2309579121	2024
	Green Synthesis of Antimicrobial Silver Nanoparticles (AgNPs) from the Mucus of the Garden Snail Cornu aspersum.	Todorova M, Petrova V, Ranguelov B, Avdeev G, Velkova L, Atanasova-Vladimirova S, Pisareva E, Tankov C, Tomova A, Dolashki A, Dolashka P.	Molecules	10.3390/molecules30102150	2025
Metabolism	Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745.	Baksh A, Kepplinger B, Isah HA, Probert MR, Clegg W, Wills C, Goodfellow M, Errington J, Allenby N, Hall MJ.	Nat Prod Res	10.1080/14786419.2016.1263854	2017
	Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells.	Wang C, Lei L, Xu Y, Li Y, Zhang J, Xu Y, Si S.	Pharmaceuticals (Basel)	10.3390/ph17040425	2024
Biotechnology	Revealing culturable fungal microbiome communities from the Arabian Peninsula desert representing a unique source of biochemicals for drug discovery and biotechnology.	Mousa W, Alramadan N, Ghemrawi R, Abu Izneid T.	F1000Res	10.12688/f1000research.158130.1	2024
	Human Metabolism of Sirolimus Revisited.	Davari B, Shokati T, Ward AM, Nguyen V, Klawitter J, Klawitter J, Christians U.	Metabolites	10.3390/metabo15070489	2025
Genetics	Complete genome of Streptomyces hygroscopicus subsp. limoneus KCTC 1717 (=KCCM 11405), a soil bacterium producing validamycin and diverse secondary metabolites.	Lee SH, Choe H, Bae KS, Park DS, Nasir A, Kim KM.	J Biotechnol	10.1016/j.jbiotec.2015.12.010	2016
Metabolism	aMSGE: advanced multiplex site-specific genome engineering with orthogonal modular recombinases in actinomycetes.	Li L, Li L, Wei K, Liu X, Wu Y, Zheng G, Chen S, Jiang W, Lu Y.	Metab Eng	10.1016/j.ymben.2018.12.001	2019
	Identification, solid-state fermentation and biocontrol effects of Streptomyces hygroscopicus B04 on strawberry root rot	Shen T, Biao Shen, Chen Wang, Hua Yang, Qirong Shen, Shimei Wang, Zhaoliang Deng.	Appl Soil Ecol	10.1016/j.apsoil.2016.02.016	2016
Genetics	Whole-genome sequencing-based characterization of Streptomyces sp. 6(4): focus on natural product.	Borba MP, Witusk JP, Cunha DM, de Lima-Morales D, Martins AF, Van Der Sand S.	Access Microbiol	10.1099/acmi.0.000466.v3	2023
	Rapamycin Increases the Development Competence of Yak (Bos grunniens) Oocytes by Promoting Autophagy via Upregulating 17beta-Estradiol and HIF-1alpha During In Vitro Maturation.	Wang M, Ma X, Zhang Q, Zhang H, Qiu S, Xu R, Pan Y.	Animals (Basel)	10.3390/ani15030365	2025
Pathogenicity	Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines.	Zhao YR, Li HM, Zhu M, Li J, Ma T, Huo Q, Hong YS, Wu CZ.	J Microbiol Biotechnol	10.4014/jmb.1710.10063	2018
	Trehalase Inhibitor Validamycin May Have Additional Mechanisms of Toxicology against Rhizoctonia cerealis.	Yang X, Shu Y, Cao S, Sun H, Zhang X, Zhang A, Li Y, Ma D, Chen H, Li W.	J Fungi (Basel)	10.3390/jof9080846	2023
Enzymology	Protocol for the purification, analysis, and handling of acyl carrier proteins from type I fatty acid and polyketide synthases.	Gusenda C, Berlage S, Burkhart I, Chagot B, Weissman KJ, Schwalbe H, Grininger M.	STAR Protoc	10.1016/j.xpro.2025.103762	2025
	Endophytic Streptomyces sp. NEAU-ZSY13 from the leaf of Perilla frutescens, as a promising broad-spectrum biocontrol agent against soil-borne diseases.	Wang Z, Gao C, Yang J, Du R, Zeng F, Bing H, Xia B, Shen Y, Liu C.	Front Microbiol	10.3389/fmicb.2023.1243610	2023
Pathogenicity	Heat Shock Proteins Revisited: Using a Mutasynthetically Generated Reblastatin Library to Compare the Inhibition of Human and Leishmania Hsp90s.	Mohammadi-Ostad-Kalayeh S, Stahl F, Scheper T, Kock K, Herrmann C, Heleno Batista FA, Borges JC, Sasse F, Eichner S, Ongouta J, Zeilinger C, Kirschning A.	Chembiochem	10.1002/cbic.201700616	2018
Enzymology	Characterization of the biochemical, physiological, and medicinal properties of Streptomyces hygroscopicus ACTMS-9H isolated from the Amazon (Brazil).	Lima SM, Melo JG, Militao GC, Lima GM, do Carmo A Lima M, Aguiar JS, Araujo RM, Braz-Filho R, Marchand P, Araujo JM, Silva TG.	Appl Microbiol Biotechnol	10.1007/s00253-016-7886-9	2017
	Beneficial Effect of Sirolimus-Pretreated Mesenchymal Stem Cell Implantation on Diabetic Retinopathy in Rats.	Kang N, Jung JS, Hwang J, Park SE, Kwon M, Yoon H, Yong J, Woo HM, Park KM.	Biomedicines	10.3390/biomedicines12020383	2024
	Enhanced Natamycin production in Streptomyces gilvosporeus through phosphate tolerance screening and transcriptome-based analysis of high-yielding mechanisms.	Wang L, Xiao W, Qiu T, Zhang H, Zhang J, Chen X.	Microb Cell Fact	10.1186/s12934-025-02696-y	2025
Metabolism	Biosynthesis of nitrogen-containing natural products, C₇N aminocyclitols and bis-indoles, from actinomycetes.	Asamizu S.	Biosci Biotechnol Biochem	10.1080/09168451.2017.1281726	2017
Metabolism	Novel spectrophotometric approach for determination of validamycin A in fermentation of Streptomyces hygroscopicus.	Li W, Feng J, Liu Y, Jiang J, Zheng X, Zhou WW.	J Biosci Bioeng	10.1016/j.jbiosc.2016.05.007	2016
	Increasing the Ascomycin Yield by Relieving the Inhibition of Acetyl/Propionyl-CoA Carboxylase by the Signal Transduction Protein GlnB.	Wang P, Wang X, Yin Y, He M, Tan W, Gao W, Wen J.	Front Microbiol	10.3389/fmicb.2021.684193	2021
Genetics	Stepwise increase of fidaxomicin in an engineered heterologous host Streptomyces albus through multi-level metabolic engineering.	Xie H, Su YT, Bu QT, Li YP, Zhao QW, Du YL, Li YQ.	Synth Syst Biotechnol	10.1016/j.synbio.2024.06.004	2024
Enzymology	Enzymatic Synthesis of Biologically Active H-Phosphinic Analogue of alpha-Ketoglutarate.	Filonov VL, Khomutov MA, Tkachev YV, Udod AV, Yanvarev DV, Giovannercole F, Khurs EN, Kochetkov SN, De Biase D, Khomutov AR.	Biomolecules	10.3390/biom14121574	2024
Pathogenicity	Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice.	Su Q, Ren YH, Liu GW, Gao YP, Zhang JX, Zhang JN, Pei XX, Li T.	Front Pharmacol	10.3389/fphar.2024.1333235	2024
	Fighting Bleb Fibrosis After Glaucoma Surgery: Updated Focus on Key Players and Novel Targets for Therapy.	Sacchi M, Tomaselli D, Ruggeri ML, Aiello FB, Sabella P, Dore S, Pinna A, Mastropasqua R, Nubile M, Agnifili L.	Int J Mol Sci	10.3390/ijms26052327	2025
Enzymology	Structural basis for the substrate recognition of aminoglycoside 7''-phosphotransferase-Ia from Streptomyces hygroscopicus.	Takenoya M, Shimamura T, Yamanaka R, Adachi Y, Ito S, Sasaki Y, Nakamura A, Yajima S.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x19011105	2019
	Biosynthesis of novel non-proteinogenic amino acids beta-hydroxyenduracididine and beta-methylphenylalanine in Escherichia coli.	Gillane R, Daygon D, Khalil ZG, Marcellin E.	Front Bioeng Biotechnol	10.3389/fbioe.2024.1468974	2024
	Screening and Selection of Antibiotics for Enhanced Production of Astaxanthin by Haematococcus lacustris.	Rayamajhi V, Byeon H, An Y, Kim T, Lee J, Lee J, Lee K, Kim C, Shin H, Jung S.	Life (Basel)	10.3390/life14080977	2024
	A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors.	Sonis ST, Villa A.	Cancers (Basel)	10.3390/cancers16010068	2023
Pathogenicity	Nigericin Exerts Anticancer Effects on Human Colorectal Cancer Cells by Inhibiting Wnt/beta-catenin Signaling Pathway.	Liu F, Li W, Hua S, Han Y, Xu Z, Wan D, Wang Y, Chen W, Kuang Y, Shi J, Zhi Q.	Mol Cancer Ther	10.1158/1535-7163.mct-17-0906	2018
	Application of impedance measurement to investigate in vitro inhalation toxicity of bacteria.	Klar S, Poether DC, Reinert J, Huttig N, Linsel G, Jackel U.	J Occup Med Toxicol	10.1186/s12995-021-00317-z	2021
	Advancing Lung Cancer Treatment with Combined c-Met Promoter-Driven Oncolytic Adenovirus and Rapamycin.	Chen SY, Wang CT, Huang TH, Tsai JL, Wang HT, Yen YT, Tseng YL, Wu CL, Chang JM, Shiau AL.	Cells	10.3390/cells13181597	2024
	Bioactive Naphthoquinone and Phenazine Analogs from the Endophytic Streptomyces sp. PH9030 as alpha-Glucosidase Inhibitors.	Ma Q, Zhong Y, Huang P, Li A, Jiang T, Jiang L, Yang H, Wang Z, Wu G, Huang X, Pu H, Liu J.	Molecules	10.3390/molecules29153450	2024
	Long-Term Outcome after Early Mammalian Target of Rapamycin Inhibitor-Based Immunosuppression in Kidney Transplant Recipients.	Liefeldt L, Waiser J, Bachmann F, Budde K, Friedersdorff F, Halleck F, Lachmann N, Peters R, Rudolph B, Unlu S, Wu K, Glander P.	J Clin Med	10.3390/jcm13154305	2024
	Impact of homologous overexpression of PR10a gene on improving salt stress tolerance in transgenic Solanum tuberosum.	Hanafy MS, Desouky AF, Asker MS, Zaki ER.	J Genet Eng Biotechnol	10.1016/j.jgeb.2024.100437	2024
	Guanidine-Containing Polyhydroxyl Macrolides: Chemistry, Biology, and Structure-Activity Relationship.	Song X, Yuan G, Li P, Cao S.	Molecules	10.3390/molecules24213913	2019
	Effect of Metabolite Extract of Streptomyces hygroscopicus subsp. hygroscopicus on Plasmodium falciparum 3D7 in Vitro.	Fitri LE, Alkarimah A, Cahyono AW, Lady WN, Endharti AT, Nugraha RYB.	Iran J Parasitol	10.18502/ijpa.v14i3.1484	2019
	Subconjunctival Sirolimus-Loaded Liposomes for the Treatment of Moderate-to-Severe Dry Eye Disease.	Salcedo-Ledesma A, Cordoba A, Zatarain-Barron NC, Graue-Hernandez EO, Garfias Y, Morales Flores N, Garcia-Sanchez GA, Garcia-Santisteban D, Linares-Alba MA, Garcia-Santisteban R, Navas A.	Clin Ophthalmol	10.2147/opth.s405841	2023
	Elaiophylin Elicits Robust Anti-Tumor Responses via Apoptosis Induction and Attenuation of Proliferation, Migration, Invasion, and Angiogenesis in Pancreatic Cancer Cells.	Huang L, Liu Y, Pan Y, Liu C, Gao H, Ren Q, Wang J, Wang H, Zhang Y, Wu A.	Molecules	10.3390/molecules28207205	2023
	Synthesis and late stage modifications of Cyl derivatives.	Servatius P, Kazmaier U.	Beilstein J Org Chem	10.3762/bjoc.18.19	2022
Metabolism	Enhanced ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by employing polyhydroxybutyrate as an intracellular carbon reservoir and optimizing carbon addition.	Wang P, Yin Y, Wang X, Wen J.	Microb Cell Fact	10.1186/s12934-021-01561-y	2021
Metabolism	Comparative analysis of rapamycin biosynthesis clusters between Actinoplanes sp. N902-109 and Streptomyces hygroscopicus ATCC29253.	Huang H, Ren SX, Yang S, Hu HF.	Chin J Nat Med	10.1016/s1875-5364(15)60012-7	2015
Enzymology	Comparative studies of the catalytic mechanisms of two chorismatases: CH-fkbo and CH-Hyg5.	Dong L, Liu Y.	Proteins	10.1002/prot.25279	2017
Phylogeny	MalaSelect: A Selective Culture Medium for Malassezia Species.	Abdillah A, Ranque S.	J Fungi (Basel)	10.3390/jof7100824	2021
	Blood microbial signatures associated with mortality in patients with sepsis: A pilot study.	Chen H, Liu W, Coker OO, Qin N, Chen H, Wang Y, Liu X, Zhang L, Choi GYS, Wong WT, Leung CCH, Ling L, Hui M, Gin T, Wong SH, Chan MTV, Wu WKK.	Heliyon	10.1016/j.heliyon.2024.e29572	2024
	Drought tolerant wheat IND-ØØ412-7 is nutritionally equivalent to its Non-Transgenic Comparator.	Miranda PV, Iglesias BF, Charriere MV, Burachik M.	GM Crops Food	10.1080/21645698.2022.2079179	2022
	t-BuOK mediated oxidative coupling amination of 1,4-naphthoquinone and related 3-indolylnaphthoquinones with amines.	Dong Y, Mei T, Luo QQ, Feng Q, Chang B, Yang F, Zhou HW, Shi ZC, Wang JY, He B.	RSC Adv	10.1039/d1ra00193k	2021
Genetics	Rapamycin as a Potential Alternative Drug for Squamous Cell Gingiva Carcinoma (Ca9-22): A Focus on Cell Cycle, Apoptosis and Autophagy Genetic Profile.	Papadakos S, Issa H, Alamri A, Alamri A, Semlali A.	Pharmaceuticals (Basel)	10.3390/ph17010131	2024
Metabolism	Endophytic Streptomyces hygroscopicus OsiSh-2-Mediated Balancing between Growth and Disease Resistance in Host Rice.	Gao Y, Ning Q, Yang Y, Liu Y, Niu S, Hu X, Pan H, Bu Z, Chen N, Guo J, Yu J, Cao L, Qin P, Xing J, Liu B, Liu X, Zhu Y.	mBio	10.1128/mbio.01566-21	2021
	Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis.	Veret D, Tejedor G, Perez E, Chomette A, Farno M, Ferreira-Lopez R, Dagneaux L, Pers YM, Jorgsensen C, Gondeau C, Brondello JM.	Stem Cell Res Ther	10.1186/s13287-024-04090-8	2025
Metabolism	Production of rapamycin in Streptomyces hygroscopicus from glycerol-based media optimized by systemic methodology.	Kim YH, Park BS, Bhatia SK, Seo HM, Jeon JM, Kim HJ, Yi DH, Lee JH, Choi KY, Park HY, Kim YG, Yang YH.	J Microbiol Biotechnol	10.4014/jmb.1403.03024	2014
Metabolism	Chemometric approach to prediction of antibacterial agent production by Streptomyces hygroscopicus.	Dodic J, Grahovac J, Kalajdzija N, Kovacevic S, Jevric L, Podunavac Kuzmanovic S.	Appl Biochem Biotechnol	10.1007/s12010-014-1115-8	2014
	Optimization of cultivation medium for enhanced production of antifungal metabolites by Streptomyces hygroscopicus	Grahovac J, Grahovac M, Dodic J, Bajic B, Balaz J.	Crop Prot	10.1016/j.cropro.2014.07.020	2014
Metabolism	Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus.	Wang B, Liu J, Liu H, Huang D, Wen J.	J Ind Microbiol Biotechnol	10.1007/s10295-015-1611-z	2015
Pathogenicity	Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach.	Nugraha RY, Faratisha IF, Mardhiyyah K, Ariel DG, Putri FF, Nafisatuzzamrudah, Winarsih S, Sardjono TW, Fitri LE.	Biomed Res Int	10.1155/2020/6135696	2020
	Rapamycin suppresses the PI3K/AKT/mTOR signaling pathway by targeting SIRT1 in esophageal cancer.	Liu T, Liang X, Sun Y, Yang S.	Exp Ther Med	10.3892/etm.2021.10624	2021
Genetics	Commercial farmed swine harbour a variety of pathogenic bacteria and antimicrobial resistance genes.	Eiamsam-Ang T, Tadee P, Buddhasiri S, Chuammitri P, Kittiwan N, Pascoe B, Patchanee P.	J Med Microbiol	10.1099/jmm.0.001787	2024
	Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus.	Xie Y, Li Q, Qin X, Ju J, Ma J.	Metab Eng Commun	10.1016/j.mec.2018.e00084	2019
Metabolism	[Construction of genetically engineered strain producing 5- oxomilbemycin by knocking out milF in Steptomyces hygroscopicus HS023].	Huang J, Lin J, Zhou M, Bai H.	Wei Sheng Wu Xue Bao		2015
	Biogenic nanoparticles as a promising drug delivery system.	Abdel-Megeed RM.	Toxicol Rep	10.1016/j.toxrep.2024.101887	2025
	Defense Responses Stimulated by Bacillus subtilis NCD-2 Through Salicylate- and Jasmonate-Dependent Signaling Pathways Protect Cotton Against Verticillium Wilt.	Mo S, Zhao W, Wei Y, Su Z, Li S, Lu X, Zhang X, Qu Y, Wang P, Dong L, Zhang J, Guo Q, Ma P.	Int J Mol Sci	10.3390/ijms26072987	2025
	Autophagy in cancer and protein conformational disorders.	Attanasio S.	FEBS Lett	10.1002/1873-3468.70061	2025
	Direct modulation of TRPM8 ion channels by rapamycin and analog macrolide immunosuppressants.	Toth BI, Bazeli B, Janssens A, Lisztes E, Racsko M, Kelemen B, Herczeg M, Nagy TM, Kover KE, Mitra A, Borics A, Biro T, Voets T.	Elife	10.7554/elife.97341	2025
	Effect of Sirolimus vs. Everolimus on CMV-Infections after Kidney Transplantation-A Network Meta-Analysis.	Wolf S, Hoffmann VS, Sommer F, Schrempf M, Li M, Ryll M, Wirth U, Ilmer M, Werner J, Andrassy J.	J Clin Med	10.3390/jcm11144216	2022
	The Chemotherapeutic Potentials of Compounds Isolated from the Plant, Marine, Fungus, and Microorganism: Their Mechanism of Action and Prospects.	Shakya AK, Naik RR.	J Trop Med	10.1155/2022/5919453	2022
	Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition.	Zhai G, Zhu Y, Sun G, Zhou F, Sun Y, Hong Z, Dong C, Leadlay PF, Hong K, Deng Z, Zhou F, Sun Y.	Nat Commun	10.1038/s41467-023-36213-9	2023
	Combination of BFHY with Cisplatin Relieved Chemotherapy Toxicity and Altered Gut Microbiota in Mice.	Feng Y, Jiang Y, Zhou Y, Li ZH, Yang QQ, Mo JF, Wen YY, Shen LP.	Int J Genomics	10.1155/2023/3568416	2023
	New C-19-modified geldanamycin derivatives: synthesis, antitumor activities, and physical properties study.	Liu YF, Zhong JJ, Lin L, Liu JJ, Wang YG, He WQ, Yang ZY.	J Asian Nat Prod Res	10.1080/10286020.2016.1160896	2016
	GEFT inhibits the GSDM-mediated proptosis signalling pathway, promoting the progression and drug resistance of rhabdomyosarcoma.	Yang F, Xia T, Zhao Z, Lin J, Zhong L, Tang T, Liao D, Lai M, Ceng J, Meng L, Li F, Liu C.	Cell Death Dis	10.1038/s41419-024-07243-y	2024
Genetics	Exploring extreme environments in Türkiye for novel P450s through metagenomic analysis.	Mumcu H, Zaugg J, Keles I, Kayrav A, Balci N, Nelson DR, Hugenholtz P, Gillam EMJ, Gul Karaguler N.	PLoS One	10.1371/journal.pone.0330523	2025
	Three Layers of Personalized Medicine in the Use of Sirolimus and Its Derivatives for the Treatment of Cancer.	Delgado A, Enkemann S.	J Pers Med	10.3390/jpm13050745	2023
	Precursor engineering and cell physiological regulation for high level rapamycin production by Streptomyces hygroscopicus	Zou X, Li J.	Ann Microbiol	10.1007/s13213-012-0597-2	2013
	Evolution and expression analysis of the caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) gene family in jute (Corchorus L.).	Kahie MA, Wang Y, Fang P, Qi J, Lei R, Xu J, Lin L, Zhang L, Zhang J, Tao A.	BMC Genomics	10.1186/s12864-023-09281-w	2023
	Successful Treatment of Non-Langerhans Cell Histiocytosis With Topical Rapamycin in Two Pediatric Cases.	Effendi RMRA, Rizqandaru T, Yuliasari R, Gondokaryono SP, Diana IA, Dwiyana RF.	Clin Cosmet Investig Dermatol	10.2147/ccid.s375995	2022
	Rapamycin improves the quality and developmental competence of in vitro matured oocytes in aged mice and humans.	Yang Q, Hu J, Wang M, Guo N, Yang L, Xi Q, Zhu L, Jin L.	Aging (Albany NY)	10.18632/aging.204401	2022
Metabolism	The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety.	Bilyk O, Samborskyy M, Leadlay PF.	PLoS One	10.1371/journal.pone.0215958	2019
	Approach to nigericin derivatives and their therapeutic potential.	Sahu AK, Said MS, Hingamire T, Gaur M, Khan A, Shanmugam D, Barvkar VT, Dharne MS, Bharde AA, Dastager SG.	RSC Adv	10.1039/d0ra05137c	2020
	Ruta graveolens, but Not Rutin, Inhibits Survival, Migration, Invasion, and Vasculogenic Mimicry of Glioblastoma Cells.	Camerino I, Franco P, Bajetto A, Thellung S, Florio T, Stoppelli MP, Colucci-D'Amato L.	Int J Mol Sci	10.3390/ijms252111789	2024
Enzymology	Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice.	Zhou Q, Harding JC, Fan P, Spasojevic I, Kovacs A, Akk A, Mitchell A, Springer LE, Gaut JP, Rauch DA, Wickline SA, Pham CTN, Fuh K, Pan H.	Nanomaterials (Basel)	10.3390/nano14211752	2024
Metabolism	A Desmethylphosphinothricin Dipeptide Derivative Effectively Inhibits Escherichia coli and Bacillus subtilis Growth.	Khomutov MA, Giovannercole F, Onillon L, Demiankova MV, Vasilieva BF, Salikhov AI, Kochetkov SN, Efremenkova OV, Khomutov AR, De Biase D.	Biomolecules	10.3390/biom13101451	2023
	The importance of choosing the appropriate cholesterol quantification method: enzymatic assay versus gas chromatography.	Serrano J, Martine L, Grosjean Y, Acar N, Alves G, Masson EAY.	J Lipid Res	10.1016/j.jlr.2024.100561	2024
	Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7.	Bidula S, Piyasirananda W, Bielecka H, Bibic L, Beekman A, Stokes L.	Purinergic Signal	10.1007/s11302-024-10055-6	2025
Enzymology	Directed evolution for thermostabilization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus.	Sugimoto N, Takakura Y, Shiraki K, Honda S, Takaya N, Hoshino T, Nakamura A.	Biosci Biotechnol Biochem	10.1271/bbb.130486	2013
Metabolism	Studies on process optimization methods for rapamycin production using Streptomyces hygroscopicus ATCC 29253.	Sinha R, Singh S, Srivastava P.	Bioprocess Biosyst Eng	10.1007/s00449-013-1051-y	2014
	NEDD4 E3 ligase-catalyzed NAMPT ubiquitination and autophagy activation are essential for pyroptosis-independent NAMPT secretion in human monocytes.	Rodriguez M, Xu H, Hernandez A, Ingraham J, Canizales J, Arce FT, Camp SM, Briggs S, Ooi A, Burke JM, Song JH, Garcia JGN.	Cell Commun Signal	10.1186/s12964-025-02164-5	2025
	Review of two immunosuppressants: tacrolimus and cyclosporine.	Lee H, Myoung H, Kim SM.	J Korean Assoc Oral Maxillofac Surg	10.5125/jkaoms.2023.49.6.311	2023
	Effects of Monensin and Rapamycin Combination Therapy on Tumor Growth and Apoptosis in a Xenograft Mouse Model of Neuroblastoma.	Serter Kocoglu S, Sunay FB, Akkaya PN.	Antibiotics (Basel)	10.3390/antibiotics12060995	2023
Metabolism	Inactivation of putative PKS genes can double geldanamycin yield in Streptomyces hygroscopicus 17997.	Li YH, Li M, He WQ, Wang YG, Shao RG.	Genet Mol Res	10.4238/2013.june.21.3	2013
	De novo biosynthesis of 2-hydroxyterephthalic acid, the monomer for high-performance hydroxyl modified PBO fiber, by enzymatic Kolbe-Schmitt reaction with CO₂ fixation.	Zhou Y, Zhang S, Huang S, Fan X, Su H, Tan T.	Biotechnol Biofuels Bioprod	10.1186/s13068-023-02413-0	2023
Enzymology	19-[(1'S,4'R)-4'-Hydroxy-1'-methoxy-2'-oxopentyl]geldanamycin, a natural geldanamycin analogue from Streptomyces hygroscopicus 17997.	Li S, Ni S, Wu L, Li L, Jiang B, Wang H, Sun G, Gan M, Li J, He W, Lin L, Wang Y, Bai S, Si S.	J Nat Prod	10.1021/np4000679	2013
	Enhanced Antifungal Efficacy of Validamycin A Co-Administered with Bacillus velezensis TCS001 against Camellia anthracnose.	Chen Z, Cao H, Jin J, Li Z, Zhang S, Chen J.	Plants (Basel)	10.3390/plants13192743	2024
	Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders.	Khanal S, Pillai M, Bhuia MS, Islam MT, Sharma O, Verma R, Nepovimova E, Kuca K, Kumar D, Chowdhury R.	Phytother Res	10.1002/ptr.70051	2025
	Computational investigation of the functional landscape of the protective role that extra virgin olive oil consumption may have on chronic lymphocytic leukemia.	Bourdakou MM, Melliou E, Magiatis P, Spyrou GM.	J Transl Med	10.1186/s12967-024-05672-z	2024
	Small Molecules Targeting INSM1 for the Treatment of High-Risk Neuroblastoma.	Lan MS, Chen C.	Biology (Basel)	10.3390/biology12081134	2023
Metabolism	New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.	Hermane J, Bulyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter JG, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A.	Chembiochem	10.1002/cbic.201402375	2015
	Natural products with gamma-pyrone scaffold from Streptomyces.	Magar RT, Sohng JK.	Appl Microbiol Biotechnol	10.1007/s00253-024-13296-y	2024
Pathogenicity	Mitochondrial Dysfunction in Systemic Lupus Erythematosus: Insights and Therapeutic Potential.	Poznyak AV, Orekhov NA, Churov AV, Starodubtseva IA, Beloyartsev DF, Kovyanova TI, Sukhorukov VN, Orekhov AN.	Diseases	10.3390/diseases12090226	2024
Pathogenicity	17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.	Zhao S, Li H, Jiang C, Ma T, Wu C, Huo Q, Liu H.	J Bioenerg Biomembr	10.1007/s10863-015-9620-1	2015
Pathogenicity	The Evolving Role of Nucleotide-binding Oligomerisation Domain-like Receptor Pyrin Domain 3 Inflammasome Activation in Vascular Endothelial Cells: A Review.	Abas R, Basir R, Mohd Thani S, Salihan S, Saat A, Mohamad Zainal NH, Mohamad Asri SF, Ab Razak NI, Mohd Nor NH, Kamaruddin NA.	Malays J Med Sci	10.21315/mjms2022.29.2.2	2022
	Petroselinum crispum, a commonly consumed food, affects sirolimus level in a renal transplant recipient: a case report.	Kurtaran M, Koc NS, Aksun MS, Yildirim T, Yilmaz SR, Erdem Y.	Ther Adv Drug Saf	10.1177/20420986211009358	2021
Genetics	Mitigating genetic instability caused by the excision activity of the phiC31 integrase in Streptomyces.	Duan Y, Liu Z, Huang X, Xu L, Wang X, Liu H, Xie Z.	Appl Environ Microbiol	10.1128/aem.01812-24	2025
	UvVelC is important for conidiation and pathogenicity in the rice false smut pathogen Ustilaginoidea virens.	Yu M, Song T, Yu J, Cao H, Pan X, Qi Z, Du Y, Liu W, Liu Y.	Virulence	10.1080/21505594.2023.2301243	2024
	Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicus and analysis of their formation processes	Cui W, Yang X, Fang Y, Zhou S, Liu S, Du G, Du K, Chen J, Tao G, Zhou Z.	Journal of the Science of Food and Agriculture.		2013
Metabolism	Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus.	Yen HW, Hsiao HP.	J Biosci Bioeng	10.1016/j.jbiosc.2013.03.011	2013
	Intravitreal sirolimus with adjunct aflibercept versus aflibercept monotherapy for persistent, exudative age-related macular degeneration: a pilot study.	Rowe LW, Minturn RJ, Burgett LA, Bracha P, Maturi RK.	Int J Retina Vitreous	10.1186/s40942-022-00437-6	2023
Pathogenicity	Hytramycins V and I, anti-Mycobacterium tuberculosis hexapeptides from a Streptomyces hygroscopicus strain.	Cai G, Napolitano JG, McAlpine JB, Wang Y, Jaki BU, Suh JW, Yang SH, Lee IA, Franzblau SG, Pauli GF, Cho S.	J Nat Prod	10.1021/np400145u	2013
Genetics	Pan-Genome of the Genus Streptomyces and Prioritization of Biosynthetic Gene Clusters With Potential to Produce Antibiotic Compounds.	Caicedo-Montoya C, Manzo-Ruiz M, Rios-Estepa R.	Front Microbiol	10.3389/fmicb.2021.677558	2021
Metabolism	Identification and characterization of antifungal active substances of Streptomyces hygroscopicus BS-112.	Zhang N, Song Z, Xie Y, Cui P, Jiang H, Yang T, Ju R, Zhao Y, Li J, Liu X.	World J Microbiol Biotechnol	10.1007/s11274-013-1307-3	2013
Pathogenicity	The influence of high glucose conditions on macrophages and its effect on the autophagy pathway.	Sousa ESA, Queiroz LAD, Guimaraes JPT, Pantoja KC, Barros RS, Epiphanio S, Martins JO.	Front Immunol	10.3389/fimmu.2023.1130662	2023
	Impact of simulated microgravity on bioremoval of heavy-metals by Lactobacillus acidophilus ATCC 4356 from water.	Afsharian Z, Salavatifar M, Khosravi Darani K.	Heliyon	10.1016/j.heliyon.2022.e12307	2022
	Two quantitative multiplex real-time PCR systems for the efficient GMO screening of food products	Koppel R, Sendic A, Waiblinger HU.	Eur Food Res Technol	10.1007/s00217-014-2261-5	2014
	Topical Treatments for Rare Genetic Dermatological Diseases: A Narrative Review.	Oliveira BA, Torres A, Ricci-Junior E, Almeida IF, Monteiro MSSB.	Pharmaceuticals (Basel)	10.3390/ph18111762	2025
	Mechanistic target of rapamycin (mTOR): a potential new therapeutic target for rheumatoid arthritis.	Zhang F, Cheng T, Zhang SX.	Arthritis Res Ther	10.1186/s13075-023-03181-w	2023
Metabolism	New geldanamycin analogs from Streptomyces hygroscopicus.	Wu CZ, Jang JH, Ahn JS, Hong YS.	J Microbiol Biotechnol	10.4014/jmb.1206.06026	2012
	Cloning, expression and medium optimization of validamycin glycosyltransferase from Streptomyces hygroscopicus var. jinggangensis for the biotransformation of validoxylamine A to produce validamycin A using free resting cells.	Fan Y, Yu Y, Jia X, Chen X, Shen Y.	Bioresour Technol	10.1016/j.biortech.2012.12.021	2013
Metabolism	Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus.	Zhao S, Huang D, Qi H, Wen J, Jia X.	Appl Microbiol Biotechnol	10.1007/s00253-013-4852-7	2013
	Identification of ferroptosis-related proteins in ameloblastoma based on proteomics analysis.	Li H, Ma X, Yang R, Mei S, Zhang X, Li X.	J Cancer Res Clin Oncol	10.1007/s00432-023-05412-8	2023
Enzymology	Improvement of transglutaminase production by extending differentiation phase of Streptomyces hygroscopicus: mechanism and application.	Chen K, Zhang D, Liu S, Wang NS, Wang M, Du G, Chen J.	Appl Microbiol Biotechnol	10.1007/s00253-012-4614-y	2013
	Monensin, an Antibiotic Isolated from Streptomyces Cinnamonensis, Regulates Human Neuroblastoma Cell Proliferation via the PI3K/AKT Signaling Pathway and Acts Synergistically with Rapamycin.	Serter Kocoglu S, Secme M, Oy C, Korkusuz G, Elmas L.	Antibiotics (Basel)	10.3390/antibiotics12030546	2023
	Bioprocess and genetic engineering aspects of ascomycin production: a review.	Sambyal K, Singh RV.	J Genet Eng Biotechnol	10.1186/s43141-020-00092-0	2020
Metabolism	Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicus and analysis of their formation processes.	Cui W, Yang X, Fang Y, Zhou S, Liu S, Du G, Du K, Chen J, Tao G, Zhou Z.	J Sci Food Agric	10.1002/jsfa.5956	2013
Pathogenicity	Metabolite extract of Streptomyces hygroscopicus Hygroscopicus inhibit the growth of Plasmodium berghei through inhibition of ubiquitin - proteasome system.	Rivo YB, Alkarimah A, Ramadhani NN, Cahyono AW, Laksmi DA, Winarsih S, Fitri LE.	Trop Biomed		2013
Metabolism	Sbi00515, a Protein of Unknown Function from Streptomyces bingchenggensis, Highlights the Functional Versatility of the Acetoacetate Decarboxylase Scaffold.	Mydy LS, Hoppe RW, Ochsenwald JM, Berndt RT, Severin GB, Schwabacher AW, Silvaggi NR.	Biochemistry	10.1021/acs.biochem.5b00483	2015
	Biochemical Characterization of GacI, a Bifunctional Glycosyltransferase-Phosphatase Enzyme Involved in Acarbose Biosynthesis in Streptomyces glaucescens GLA.O.	Tsunoda T, Asamizu S, Mahmud T.	Biochemistry	10.1021/acs.biochem.2c00473	2022
	Enhancement of ascomycin production via a combination of atmospheric and room temperature plasma mutagenesis in Streptomyces hygroscopicus and medium optimization.	Yu Z, Shen X, Wu Y, Yang S, Ju D, Chen S.	AMB Express	10.1186/s13568-019-0749-x	2019
	Chemoenzymatic Synthesis of Novel Cytotoxic Epoxyketones Using the Eponemycin Biosynthetic Enzyme EpnF.	Corless BC, Geissen R, Prescott NA, David Y, Scheinberg DA, Tan DS.	ACS Chem Biol	10.1021/acschembio.3c00080	2023
	Mifepristone and rapamycin have non-additive benefits for life span in mated female Drosophila.	Landis GN, Baybutt B, Das S, Fan Y, Olsen K, Yan K, Tower J.	Fly (Austin)	10.1080/19336934.2024.2419151	2024
	Response Surface Methodology (RSM) Mediated Optimization of Medium Components for Mycelial Growth and Metabolites Production of Streptomyces alfalfae XN-04.	Chen J, Lan X, Jia R, Hu L, Wang Y.	Microorganisms	10.3390/microorganisms10091854	2022
Proteome	Personalization of pharmacotherapy with sirolimus based on volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients-from LC-MS/MS method validation to clinical application.	Kocur A, Czajkowska A, Rebis K, Rubik J, Moczulski M, Kot B, Sierakowski M, Pawinski T.	Pharmacol Rep	10.1007/s43440-024-00663-9	2024
	Efficient pathway-driven scyllo-inositol production from myo-inositol using thermophilic cells and mesophilic inositol dehydrogenases: a novel strategy for pathway control.	Kurashiki R, Takahashi M, Okumura Y, Ono T, Endo H, Makino K, Fukui K, Yokoyama K, Ishikawa S, Yoshida K-i, Ohshiro T, Suzuki H.	Appl Environ Microbiol	10.1128/aem.00281-24	2024
	Influence of Molecular Structure and Physicochemical Properties of Immunosuppressive Drugs on Micelle Formulation Characteristics and Cutaneous Delivery.	Quartier J, Lapteva M, Boulaguiem Y, Guerrier S, Kalia YN.	Pharmaceutics	10.3390/pharmaceutics15041278	2023
	Improved Productivity of Streptomyces mobaraensis Transglutaminase by Regulating Zymogen Activation.	Yin X, Rao S, Zhou J, Du G, Chen J, Liu S.	Front Bioeng Biotechnol	10.3389/fbioe.2022.878795	2022
	Roles of Phyllosphere Microbes in Rice Health and Productivity.	Danso Ofori A, Su W, Zheng T, Datsomor O, Titriku JK, Xiang X, Kandhro AG, Ahmed MI, Mawuli EW, Awuah RT, Zheng A.	Plants (Basel)	10.3390/plants13233268	2024
Metabolism	Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997.	Lin L, Ni S, Wu L, Wang Y, Wang Y, Tao P, He W, Wang X.	Biosci Biotechnol Biochem	10.1271/bbb.110361	2011
	mTORopathies in Epilepsy and Neurodevelopmental Disorders: The Future of Therapeutics and the Role of Gene Editing.	Boff MO, Xavier FAC, Diz FM, Goncalves JB, Ferreira LM, Zambeli J, Pazzin DB, Previato TTR, Erwig HS, Goncalves JIB, Bruzzo FTK, Marinowic D, da Costa JC, Zanirati G.	Cells	10.3390/cells14090662	2025
Metabolism	[Effect of casamino acid on intergeneric conjugation in rapamycin-producing Streptomyces hygroscopicus ATCC29253].	Zhang W, Lu H, He J.	Wei Sheng Wu Xue Bao		2012
Metabolism	Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus.	Kim EY, Han JW, Lee JY, Kim BS.	Folia Microbiol (Praha)	10.1007/s12223-012-0173-y	2012
	Revealing the impact of Rapamycin on the virulence factors of the Candida haemulonii complex.	Alves V, de Andrade IB, Correa-Junior D, Avellar-Moura I, Passos K, Soares J, Pontes B, Almeida MA, Almeida-Paes R, Frases S.	Curr Res Microb Sci	10.1016/j.crmicr.2024.100247	2024
Metabolism	Biogenic synthesis of multidimensional gold nanoparticles assisted by Streptomyces hygroscopicus and its electrochemical and antibacterial properties.	Sadhasivam S, Shanmugam P, Veerapandian M, Subbiah R, Yun K.	Biometals	10.1007/s10534-011-9506-6	2012
	Enhanced rapamycin production in Streptomyces hygroscopicus by integrative expression of aveR, a LAL family transcriptional regulator	Huang M, Li M, Feng Z, Liu Y, Chu Y, Tian Y.	World J Microbiol Biotechnol	10.1007/s11274-011-0673-y	2011
	A High-Throughput Method Based on Microculture Technology for Screening of High-Yield Strains of Tylosin-Producing Streptomyces fradiae.	Yao Z, Fan J, Dai J, Yu C, Zeng H, Li Q, Hu W, Yan C, Hao M, Li H, Li S, Liu J, Huang Q, Li L, Zhou R.	J Microbiol Biotechnol	10.4014/jmb.2210.10023	2023
	Platelet-Rich Fibrin Reduces IL-1beta Release from Macrophages Undergoing Pyroptosis.	Sordi MB, Panahipour L, Kargarpour Z, Gruber R.	Int J Mol Sci	10.3390/ijms23158306	2022
Phylogeny	Taxonomic evaluation of the Streptomyces hygroscopicus clade using multilocus sequence analysis and DNA-DNA hybridization, validating the MLSA scheme for systematics of the whole genus.	Rong X, Huang Y.	Syst Appl Microbiol	10.1016/j.syapm.2011.10.004	2012
Metabolism	Thiazinogeldanamycin, a new geldanamycin derivative produced by Streptomyces hygroscopicus 17997.	Ni S, Wu L, Wang H, Gan M, Wang Y, He W, Wang Y.	J Microbiol Biotechnol	10.4014/jmb.1011.11006	2011
	Metabolomic Profiling and Molecular Networking of Nudibranch-Associated Streptomyces sp. SCSIO 001680.	Abdelrahman SM, Dosoky NS, Hanora AM, Lopanik NB.	Molecules	10.3390/molecules27144542	2022
	The Effects and Mechanisms of the Rapamycin-eluting Stent in Urethral Stricture Prevention in Rabbits.	Zhang T, Zhao W, Ren T, Chen J, Chen Z, Wang Y, Cheng X, Wu J, Yuan C, He T.	Balkan Med J	10.4274/balkanmedj.galenos.2021.2021-4-77	2022
	Acupuncture combined with moxibustion mitigates spinal cord injury-induced motor dysfunction in mice by NLRP3-IL-18 signaling pathway inhibition.	Zheng JH, Yuan N, Zhang P, Liu DF, Lin W, Miao J.	J Orthop Surg Res	10.1186/s13018-023-03902-6	2023
	Connecting dots between nucleotide biosynthesis and DNA lesion repair/bypass in cancer.	Lin JC, Oludare A, Jung H.	Biosci Rep	10.1042/bsr20231382	2024
	Bioreduction of aryl azides during mutasynthesis of new ansamitocins.	Mancuso L, Jurjens G, Hermane J, Harmrolfs K, Eichner S, Fohrer J, Collisi W, Sasse F, Kirschning A.	Org Lett	10.1021/ol401989e	2013
	Developing Actinobacterial Endophytes as Biocontrol Products for Fusarium pseudograminearum in Wheat.	O'Sullivan CA, Roper MM, Myers CA, Thatcher LF.	Front Bioeng Biotechnol	10.3389/fbioe.2021.691770	2021
Metabolism	[Rapid identification of elaiophylin from Streptomyces hygroscopicus 17997, a geldanamycin producer].	Li S, Wu L, Chen F, Wang H, Sun G, Wang Y.	Sheng Wu Gong Cheng Xue Bao		2011
Metabolism	HygY Is a Twitch Radical SAM Epimerase with Latent Dehydrogenase Activity Revealed upon Mutation of a Single Cysteine Residue.	Besandre RA, Chen Z, Davis I, Zhang J, Ruszczycky MW, Liu A, Liu HW.	J Am Chem Soc	10.1021/jacs.1c05727	2021
	Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens.	Wang J, Xu C, Sun Q, Xu J, Chai Y, Berg G, Cernava T, Ma Z, Chen Y.	Microbiome	10.1186/s40168-021-01077-y	2021
	Plant-Based HSP90 Inhibitors in Breast Cancer Models: A Systematic Review.	Zarguan I, Ghoul S, Belayachi L, Benjouad A.	Int J Mol Sci	10.3390/ijms25105468	2024
Pathogenicity	The Role of Inflammasome-Associated Innate Immune Receptors in Cancer.	Dawson RE, Jenkins BJ.	Immune Netw	10.4110/in.2024.24.e38	2024
Pathogenicity	Translation elongation defects activate the Caenorhabditis elegans ZIP-2 bZIP transcription factor-mediated toxin defense.	Kniazeva M, Ruvkun G.	Proc Natl Acad Sci U S A	10.1073/pnas.2423578122	2025
	Recent Update and Drug Target in Molecular and Pharmacological Insights into Autophagy Modulation in Cancer Treatment and Future Progress.	Rahman MA, Saikat ASM, Rahman MS, Islam M, Parvez MAK, Kim B.	Cells	10.3390/cells12030458	2023
Genetics	Applications of genome-scale metabolic models to investigate microbial metabolic adaptations in response to genetic or environmental perturbations.	Carter EL, Constantinidou C, Alam MT.	Brief Bioinform	10.1093/bib/bbad439	2023
Metabolism	The pro-region of Streptomyces hygroscopicus transglutaminase affects its secretion by Escherichia coli.	Liu S, Zhang D, Wang M, Cui W, Chen K, Liu Y, Du G, Chen J, Zhou Z.	FEMS Microbiol Lett	10.1111/j.1574-6968.2011.02387.x	2011
	Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status.	Masci M, Caproni R, Nevigato T.	Methods Protoc	10.3390/mps7030038	2024
	The Rice Endophyte-Derived alpha-Mannosidase ShAM1 Degrades Host Cell Walls To Activate DAMP-Triggered Immunity against Disease.	Bu Z, Li W, Liu X, Liu Y, Gao Y, Pei G, Zhuo R, Cui K, Qin Z, Zheng H, Wu J, Yang Y, Su P, Cao M, Xiong X, Liu X, Zhu Y.	Microbiol Spectr	10.1128/spectrum.04824-22	2023
Genetics	Sex, tissue, and mitochondrial interactions modify the transcriptional response to rapamycin in Drosophila.	Raynes Y, Santiago JC, Lemieux FA, Darwin L, Rand DM.	BMC Genomics	10.1186/s12864-024-10647-x	2024
	An overview of the two-component system GarR/GarS role on antibiotic production in Streptomyces coelicolor.	Cruz-Bautista R, Zelarayan-Aguero A, Ruiz-Villafan B, Escalante-Lozada A, Rodriguez-Sanoja R, Sanchez S.	Appl Microbiol Biotechnol	10.1007/s00253-024-13136-z	2024
	An atypical two-component system, AtcR/AtcK, simultaneously regulates the biosynthesis of multiple secondary metabolites in Streptomyces bingchenggensis.	Yan Y-S, Zou L-S, Wei H-G, Yang M-Y, Yang Y-Q, Li X-F, Xia H-Y.	Appl Environ Microbiol	10.1128/aem.01300-23	2024
	Comparative study of adipose tissue derived mesenchymal stem cells with rapamycin on paraquat-induced acute lung injury and pulmonary fibrosis in a mouse model: histological and biochemical study.	Fikry H, Saleh LA, Sadek DR.	Stem Cell Res Ther	10.1186/s13287-025-04498-w	2025
	Micrococcus lylae MW407006 Pigment: Production, Optimization, Nano-Pigment Synthesis, and Biological Activities.	Shahin YH, Elwakil BH, Ghareeb DA, Olama ZA.	Biology (Basel)	10.3390/biology11081171	2022
	Discovery of a highly efficient TylF methyltransferase via random mutagenesis for improving tylosin production.	Fan J, Yao Z, Yan C, Hao M, Dai J, Zou W, Ni M, Li T, Li L, Li S, Liu J, Huang Q, Zhou R.	Comput Struct Biotechnol J	10.1016/j.csbj.2023.04.005	2023
	The Evolving Landscape of Therapeutics for Epilepsy in Tuberous Sclerosis Complex.	Vitale G, Terrone G, Vitale S, Vitulli F, Aiello S, Bravaccio C, Pisano S, Bove I, Rizzo F, Seetahal-Maraj P, Wiese T.	Biomedicines	10.3390/biomedicines11123241	2023
	Combined Deep Learning and Molecular Modeling Techniques on the Virtual Screening of New mTOR Inhibitors from the Thai Mushroom Database.	Posansee K, Liangruksa M, Termsaithong T, Saparpakorn P, Hannongbua S, Laomettachit T, Sutthibutpong T.	ACS Omega	10.1021/acsomega.3c04827	2023
	Identification and Expression Analysis of EPSPS and BAR Families in Cotton.	Li Z, Zhang Z, Liu Y, Ma Y, Lv X, Zhang D, Gu Q, Ke H, Wu L, Zhang G, Ma Z, Wang X, Sun Z.	Plants (Basel)	10.3390/plants12193366	2023
Enzymology	Decoyinine Induced Resistance in Rice against Small Brown Planthopper Laodelphax striatellus.	Shah AZ, Ma C, Zhang Y, Zhang Q, Xu G, Yang G.	Insects	10.3390/insects13010104	2022
	Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges.	Sadiq S, Sadiq S, Khan I, Shen Z, Wang M, Xu T, Khan S, Zhou X, Bahadur A, Rafiq M, Sohail S, Wu P.	Molecules	10.3390/molecules28227674	2023
	Histone Deacetylase Inhibitors: A Promising Therapeutic Alternative for Endometrial Carcinoma.	Psilopatis I, Pergaris A, Giaginis C, Theocharis S.	Dis Markers	10.1155/2021/7850688	2021
	Rapamycin Treatment Alleviates Chronic GVHD-Induced Lupus Nephritis in Mice by Recovering IL-2 Production and Regulatory T Cells While Inhibiting Effector T Cells Activation.	Zhang J, Wang X, Wang R, Chen G, Wang J, Feng J, Li Y, Yu Z, Xiao H.	Biomedicines	10.3390/biomedicines11030949	2023
	Sirolimus is effective for primary refractory/relapsed warm autoimmune haemolytic anaemia/Evans syndrome: a retrospective single-center study.	Zhang Z, Hu Q, Yang C, Chen M, Han B.	Ann Med	10.1080/07853890.2023.2282180	2023
Enzymology	[Effect of transglutaminase-gene disruption in Streptomyces hygroscopicus on cell differentiation].	Chen K, Liu S, Ju X, Ma T, Zhang D, Du G, Chen J.	Wei Sheng Wu Xue Bao		2010
	Efficacy and Safety of Topical Mechanistic Target of Rapamycin Inhibitors for Facial Angiofibromas in Patients with Tuberous Sclerosis Complex: A Systematic Review and Network Meta-Analysis.	Lin YT, Yu CL, Tu YK, Chi CC.	Biomedicines	10.3390/biomedicines10040826	2022
Metabolism	Identification of three positive regulators in the geldanamycin PKS gene cluster of Streptomyces hygroscopicus JCM4427.	Kim W, Lee JJ, Paik SG, Hong YS.	J Microbiol Biotechnol	10.4014/jmb.1005.05040	2010
	Combinatorial Biosynthesis Creates a Novel Aglycone Polyether with High Potency and Low Side Effects Against Bladder Cancer.	Yan P, Wang G, Huang M, Liu Z, Dai C, Hu B, Gu M, Deng Z, Liu R, Wang X, Liu T.	Adv Sci (Weinh)	10.1002/advs.202404668	2024
	Engineered Extracellular Vesicles with Compound-Induced Cargo Delivery to Solid Tumors.	Kim R, Kim JH.	Int J Mol Sci	10.3390/ijms24119368	2023
Metabolism	Heterologous expression of a putative K+/H+ antiporter of S. coelicolor A3(2) enhances K+, acidic-pH shock tolerances, and geldanamycin secretion.	Song JY, Seo YB, Hong SK, Chang YK.	J Microbiol Biotechnol	10.4014/jmb.1207.07030	2013
Metabolism	Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90.	Millson SH, Chua CS, Roe SM, Polier S, Solovieva S, Pearl LH, Sim TS, Prodromou C, Piper PW.	FASEB J	10.1096/fj.11-188821	2011
	Side Effects of Immunosuppressant Drugs After Liver Transplant.	Gabrielli F, Bernasconi E, Toscano A, Avossa A, Cavicchioli A, Andreone P, Gitto S.	Pharmaceuticals (Basel)	10.3390/ph18030342	2025
Metabolism	[Isolation, purification and characterization of antifungal substances from Streptomyces hygroscopicus BS-112].	Zhang N, Sun C, Song Z, Guo H, Zhang B, Qiu N, Liu X.	Wei Sheng Wu Xue Bao		2011
	Current and emerging approaches for eliminating Borrelia burgdorferi and alleviating persistent Lyme disease symptoms.	Zafar K, Azuama OC, Parveen N.	Front Microbiol	10.3389/fmicb.2024.1459202	2024
	Exploring the Potential of Halotolerant Actinomycetes from Rann of Kutch, India: A Study on the Synthesis, Characterization, and Biomedical Applications of Silver Nanoparticles.	Dayma P, Choudhary N, Ali D, Alarifi S, Dudhagara P, Luhana K, Yadav VK, Patel A, Patel R.	Pharmaceuticals (Basel)	10.3390/ph17060743	2024
	Bioinformatics approach to identify the hub gene associated with COVID-19 and idiopathic pulmonary fibrosis.	Shi W, Li T, Li H, Ren J, Lv M, Wang Q, He Y, Yu Y, Liu L, Jin S, Chen H.	IET Syst Biol	10.1049/syb2.12080	2023
Metabolism	Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis.	Li T, Ni S, Jia C, Wang H, Sun G, Wu L, Gan M, Shan G, He W, Lin L, Zhou H, Wang Y.	J Nat Prod	10.1021/np3001738	2012
Genetics	Evaluation of Streptomyces sporoverrucosus B-1662 for biological control of red pepper anthracnose and apple bitter rot diseases in Korea.	Kim D, Kim J, Lee Y, Balaraju K, Hwang YJ, Lee MH, Cheon W, Mun HY, Lee CS, Jeon Y.	Front Microbiol	10.3389/fmicb.2024.1429646	2024
	Chemical Identification of Secondary Metabolites from Rhizospheric Actinomycetes Using LC-MS Analysis: In Silico Antifungal Evaluation and Growth-Promoting Effects.	Elshafie HS, De Martino L, Formisano C, Caputo L, De Feo V, Camele I.	Plants (Basel)	10.3390/plants12091869	2023
	Active secretion of a thermostable transglutaminase variant in Escherichia coli.	Wang X, Zhao B, Du J, Xu Y, Zhu X, Zhou J, Rao S, Du G, Chen J, Liu S.	Microb Cell Fact	10.1186/s12934-022-01801-9	2022
	Biosynthesis of silver nanoparticles by Streptomyces hygroscopicus and antimicrobial activity against medically important pathogenic microorganisms.	Sadhasivam S, Shanmugam P, Yun K.	Colloids Surf B Biointerfaces	10.1016/j.colsurfb.2010.07.036	2010
	Microsponge-derived mini tablets loaded with immunosuppressive agents: Pharmacokinetic investigation in human volunteers, cell viability and IVIVC correlation.	Mehmood Y, Shahid H, Abbas M, Farooq U, Farooq U, Ali S, Kazi M.	Saudi Pharm J	10.1016/j.jsps.2023.101799	2023
	Bacillus paralicheniformis RP01 Enhances the Expression of Growth-Related Genes in Cotton and Promotes Plant Growth by Altering Microbiota inside and outside the Root.	Xu J, Qin L, Xu X, Shen H, Yang X.	Int J Mol Sci	10.3390/ijms24087227	2023
	Rapamycin downregulates alpha-klotho in the kidneys of female rats with normal and reduced renal function	Espartero A, Vidal A, Lopez I, Raya A, Rodriguez M, Aguilera-Tejero E, Pineda C.	PLoS One		2023
Genetics	An Expansion of the Endoplasmic Reticulum that Halts Autophagy is Permissive to Genome Instability.	Lara-Barba E, Toran-Vilarrubias A, Moriel-Carretero M.	Contact (Thousand Oaks)	10.1177/25152564231157706	2023
Genetics	Initial dose recommendation for sirolimus in paediatric kaposiform haemangioendothelioma patients based on population pharmacokinetics and pharmacogenomics.	Chen X, Wang DD, Xu H, Li ZP.	J Int Med Res	10.1177/0300060520947627	2020
	Improved antimicrobial compound production by a new isolate Streptomyces hygroscopicus MTCC 4003 using Plackett-Burman design and response Surface methodology.	Singh N, Rai V.	Bioinformation	10.6026/97320630081021	2012
Metabolism	Bioinformatic Analysis of Two TOR (Target of Rapamycin)-Like Proteins Encoded by Entamoeba histolytica Revealed Structural Similarities with Functional Homologs.	Munoz-Munoz PLA, Mares-Alejandre RE, Melendez-Lopez SG, Ramos-Ibarra MA.	Genes (Basel)	10.3390/genes12081139	2021
	Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer.	Wu L, Bai S, Huang J, Cui G, Li Q, Wang J, Du X, Fu W, Li C, Wei W, Lin H, Luo ML.	Cancers (Basel)	10.3390/cancers15123221	2023
Biotechnology	Efficient biosynthesis of transglutaminase in Streptomyces mobaraensis via systematic engineering strategies.	Yuan F, Li G, Li Z, Li M, Liu X, Yang H, Yu X.	Curr Res Food Sci	10.1016/j.crfs.2024.100756	2024
	Computed Tomography Angiography under Deep Learning in the Treatment of Atherosclerosis with Rapamycin.	Ji F, Zhou S, Bi Z.	J Healthc Eng	10.1155/2021/4543702	2021
Genetics	Induced Cell Cycle Arrest in Triple-Negative Breast Cancer by Combined Treatment of Itraconazole and Rapamycin.	Wu HT, Li CL, Fang ZX, Chen WJ, Lin WT, Liu J.	Front Pharmacol	10.3389/fphar.2022.873131	2022
Pathogenicity	The expression of URGCP gene in prostate cancer cell lines: correlation with rapamycin.	Dodurga Y, Avci CB, Susluer SY, Satiroglu Tufan NL, Gunduz C.	Mol Biol Rep	10.1007/s11033-012-1891-6	2012
	Rapamycin improves the developmental competence of human oocytes by alleviating DNA damage during IVM.	Yang Q, Xi Q, Wang M, Liu J, Li Z, Hu J, Jin L, Zhu L.	Hum Reprod Open	10.1093/hropen/hoac050	2022
Metabolism	Optimization of the production medium for biosynthesis of antifungal antibiotic AK-111-81 by phosphate-deregulated mutant of Streptomyces hygroscopicus.	Gesheva V.	Appl Biochem Biotechnol	10.1007/s12010-009-8629-5	2009
	[Structural organization of the phospholipid constituent of cell membranes from Streptomyces hygroscopicus, as determined from neutron diffraction data].	Kiselev MA, Ermakova EV, Fillippova SN, Surgucheva NA, Dante S, Hauss T, Gal'chenko VF.	Biofizika		2009
	Tuberous Sclerosis, Type II Diabetes Mellitus and the PI3K/AKT/mTOR Signaling Pathways-Case Report and Literature Review.	Jurca CM, Kozma K, Petchesi CD, Zaha DC, Magyar I, Munteanu M, Faur L, Jurca A, Bembea D, Severin E, Jurca AD.	Genes (Basel)	10.3390/genes14020433	2023
Enzymology	Improving the active expression of transglutaminase in Streptomyces lividans by promoter engineering and codon optimization.	Liu S, Wang M, Du G, Chen J.	BMC Biotechnol	10.1186/s12896-016-0304-7	2016
	An Intriguing Purview on the Design of Macrocyclic Inhibitors for Unexplored Protein Kinases through Their Binding Site Comparison.	Bhujbal SP, Hah JM.	Pharmaceuticals (Basel)	10.3390/ph16071009	2023
	Dual RNA Sequencing Analysis of Bacillus amyloliquefaciens and Sclerotinia sclerotiorum During Infection of Soybean Seedlings by S. sclerotiorum Unveils Antagonistic Interactions.	Cheng Y, Gao X, He H, Zhang X, Wang R, Liu J.	Front Microbiol	10.3389/fmicb.2022.924313	2022
	Biosynthesis of Polyketides in Streptomyces.	Risdian C, Mozef T, Wink J.	Microorganisms	10.3390/microorganisms7050124	2019
Metabolism	Effect of fermentation temperature on validamycin A production by Streptomyces hygroscopicus 5008.	Liao Y, Wei ZH, Bai L, Deng Z, Zhong JJ.	J Biotechnol	10.1016/j.jbiotec.2009.04.015	2009
	Development of the first geldanamycin-based HSP90 degraders.	Wurnig S, Vogt M, Hogenkamp J, Dienstbier N, Borkhardt A, Bhatia S, Hansen FK.	Front Chem	10.3389/fchem.2023.1219883	2023
Phenotype	Effects of Sirolimus treatment on patients with beta-Thalassemia: Lymphocyte immunophenotype and biological activity of memory CD4⁺ and CD8⁺ T cells.	Zurlo M, Nicoli F, Proietto D, Dallan B, Zuccato C, Cosenza LC, Gasparello J, Papi C, d'Aversa E, Borgatti M, Scapoli C, Finotti A, Gambari R.	J Cell Mol Med	10.1111/jcmm.17655	2023
	A Low Dose of Rapamycin Promotes Hair Cell Differentiation by Enriching SOX2⁺ Progenitors in the Neonatal Mouse Inner Ear Organoids.	Wu W, Chen P, Yang J, Liu Y.	J Assoc Res Otolaryngol	10.1007/s10162-024-00938-1	2024
Metabolism	Pleiotropic effects of antibiotics on T cell metabolism and T cell-mediated immunity.	Franz T, Negele J, Bruno P, Bottcher M, Mitchell-Flack M, Reemts L, Krone A, Mougiakakos D, Muller AJ, Zautner AE, Kahlfuss S.	Front Microbiol	10.3389/fmicb.2022.975436	2022
Enzymology	Isolation and structure of homotemsirolimuses A, B, and C.	Kong F, Zhu T, Yu K, Pagano TG, Desai P, Radebaugh G, Fawzi M.	J Nat Prod	10.1021/np1003388	2011
	Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin.	Sidorov VY, Sidorova TN, Samson PC, Reiserer RS, Britt CM, Neely MD, Ess KC, Wikswo JP.	Bioengineering (Basel)	10.3390/bioengineering11030234	2024
	Expression of fatty acid related gene promotes astaxanthin heterologous production in Chlamydomonas reinhardtii.	Sun JP, Wei XH, Cong XM, Zhang WH, Qiu LX, Zang XN.	Front Nutr	10.3389/fnut.2023.1130065	2023
Metabolism	Tivantinib Hampers the Proliferation of Glioblastoma Cells via PI3K/Akt/Mammalian Target of Rapamycin (mTOR) Signaling.	Wu Y, Li Z, Zhang L, Liu G.	Med Sci Monit	10.12659/msm.919319	2019
	Regulation of Geldanamycin Biosynthesis by Cluster-Situated Transcription Factors and the Master Regulator PhoP.	Martin JF, Ramos A, Liras P.	Antibiotics (Basel)	10.3390/antibiotics8030087	2019
	GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c-MET tyrosine kinase.	Okayama M, Fujimori K, Sato M, Samata K, Kurita K, Sugiyama H, Suto Y, Iwasaki G, Yamada T, Kiuchi F, Ichikawa D, Matsushita M, Hirao M, Kunieda H, Yamazaki K, Hattori Y.	Cancer Med	10.1002/cam4.5691	2023
	Signaling Pathways Leading to mTOR Activation Downstream Cytokine Receptors in Lymphocytes in Health and Disease.	Fallone L, Walzer T, Marcais A.	Int J Mol Sci	10.3390/ijms241612736	2023
	Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation.	Yang Q, Xi Q, Wang M, Long R, Hu J, Li Z, Ren X, Zhu L, Jin L.	Reprod Biol Endocrinol	10.1186/s12958-022-00943-0	2022
	The Inhibitory Effect of Validamycin A on Aspergillus flavus.	Plabutong N, Ekronarongchai S, Niwetbowornchai N, Edwards SW, Virakul S, Chiewchengchol D, Thammahong A.	Int J Microbiol	10.1155/2020/3972415	2020
	The m-TORC1 inhibitor Sirolimus increases the effectiveness of Photodynamic therapy in the treatment of cutaneous Squamous Cell Carcinoma, impairing NRF2 antioxidant signaling.	Nicolas-Morala J, Mascaraque-Checa M, Gallego-Rentero M, Barahona A, Abarca-Lachen E, Carrasco E, Gilaberte Y, Gonzalez S, Juarranz A.	Int J Biol Sci	10.7150/ijbs.94883	2024
	Epigenetic Modification: A Key Tool for Secondary Metabolite Production in Microorganisms.	Bind S, Bind S, Sharma AK, Chaturvedi P.	Front Microbiol	10.3389/fmicb.2022.784109	2022
	Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.	Menzella HG, Tran TT, Carney JR, Lau-Wee J, Galazzo J, Reeves CD, Carreras C, Mukadam S, Eng S, Zhong Z, Timmermans PB, Murli S, Ashley GW.	J Med Chem	10.1021/jm900012a	2009
Metabolism	[Roles of geldanamycin biosynthetic genes in Streptomyces hygroscopicus 17997].	He W, Liu Y, Sun G, Wang Y.	Sheng Wu Gong Cheng Xue Bao	10.1016/s1872-2075(08)60055-2	2008
	Sirolimus treatment for paediatric head and neck lymphatic malformations: a systematic review.	Saibene AM, Rosso C, Felisati G, Pignataro L, Schindler A, Ghilardi G, Colletti G, Gaffuri M, Mozzanica F.	Eur Arch Otorhinolaryngol	10.1007/s00405-023-07991-1	2023
	Natural products' antiangiogenic roles in gynecological cancer.	Jia S, Li L, Yu C, Peng F.	Front Pharmacol	10.3389/fphar.2024.1353056	2024
Metabolism	A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997.	Li Y, He W, Wang Y, Wang Y, Shao R.	J Antibiot (Tokyo)	10.1038/ja.2008.49	2008
Metabolism	The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment.	Maiese K.	Curr Neurovasc Res	10.2174/1567202617666200425205122	2020
Genetics	Production of Epoxyketone Peptide-Based Proteasome Inhibitors by Streptomyces sp. BRA-346: Regulation and Biosynthesis.	Domingues Vieira B, Niero H, de Felicio R, Giolo Alves LF, Freitas Bazzano C, Sigrist R, Costa Furtado L, Felix Persinoti G, Veras Costa-Lotufo L, Barretto Barbosa Trivella D.	Front Microbiol	10.3389/fmicb.2022.786008	2022
	Schisandrin protects against ulcerative colitis by inhibiting the SGK1/NLRP3 signaling pathway and reshaping gut microbiota in mice.	Wang X, Shen C, Wang X, Tang J, Wu Z, Huang Y, Shao W, Geng K, Xie H, Pu Z.	Chin Med	10.1186/s13020-023-00815-8	2023
Metabolism	Spontaneous white sectored-mutants in Streptomyces hygroscopicus 111-81: characterization and antibiotic productivity.	Gesheva V.	Curr Microbiol	10.1007/s00284-008-9165-1	2008
Pathogenicity	Differential protein expression in endothelial cells exposed to serum from patients with acute graft-vs-host disease, depending on steroid response.	Martinez-Sanchez J, Palomo M, Pedraza A, Moreno-Castano AB, Torramade-Moix S, Rovira M, Salas MQ, Cid J, Escolar G, Penack O, Carreras E, Diaz-Ricart M.	J Cell Mol Med	10.1111/jcmm.17712	2023
Metabolism	Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427.	Shin JC, Na Z, Lee DH, Kim WC, Lee K, Shen YM, Paik SG, Hong YS, Lee JJ.	J Microbiol Biotechnol		2008
	Engineering a Synthetic Pathway for Gentisate in Pseudomonas Chlororaphis P3.	Wang S, Fu C, Liu K, Cui J, Hu H, Wang W, Zhang X.	Front Bioeng Biotechnol	10.3389/fbioe.2020.622226	2020
Metabolism	Autophagy and Mitophagy Promotion in a Rat Model of Endometriosis.	Siracusa R, D'Amico R, Impellizzeri D, Cordaro M, Peritore AF, Gugliandolo E, Crupi R, Salinaro AT, Raffone E, Genovese T, Cuzzocrea S, Fusco R, Di Paola R.	Int J Mol Sci	10.3390/ijms22105074	2021
Metabolism	Two different proteases from Streptomyces hygroscopicus are involved in transglutaminase activation.	Zhang D, Wang M, Wu J, Cui L, Du G, Chen J.	J Agric Food Chem	10.1021/jf8008519	2008
Metabolism	Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus.	Ilic SB, Konstantinovic SS, Veljkovic VB, Savic DS, Lazic ML, Gojgic-Cvijovic G.	Curr Microbiol	10.1007/s00284-008-9143-7	2008
	Antagonistic Effect of Streptomyces sp. BS062 against Botrytis Diseases.	Kim YS, Lee IK, Yun BS.	Mycobiology	10.5941/myco.2015.43.3.339	2015
	Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages.	Diaz-Pino R, Rice GI, San Felipe D, Pepanashvili T, Kasher PR, Briggs TA, Lopez-Castejon G.	Life Sci Alliance	10.26508/lsa.202302399	2024
	Surfactant protein of the Streptomyces subtilisin inhibitor family inhibits transglutaminase activation in Streptomyces hygroscopicus.	Zhang D, Wang M, Du G, Zhao Q, Wu J, Chen J.	J Agric Food Chem	10.1021/jf703567t	2008
Metabolism	Biosynthesis of rapamycin and its regulation: past achievements and recent progress.	Park SR, Yoo YJ, Ban YH, Yoon YJ.	J Antibiot (Tokyo)	10.1038/ja.2010.71	2010
Metabolism	Isolation, Purification, and Characterization of Heparinase from Streptomyces variabilis MTCC 12266.	Singh V, Haque S, Kumari V, El-Enshasy HA, Mishra BN, Somvanshi P, Tripathi CKM.	Sci Rep	10.1038/s41598-019-42740-7	2019
	Repurposing Avermectins and Milbemycins against Mycobacteroides abscessus and Other Nontuberculous Mycobacteria.	Munoz-Munoz L, Shoen C, Sweet G, Vitoria A, Bull TJ, Cynamon M, Thompson CJ, Ramon-Garcia S.	Antibiotics (Basel)	10.3390/antibiotics10040381	2021
	Research progress on GlnR-mediated regulation in Actinomycetes.	Gao B, Li G, Gu D, Wang J.	Front Microbiol	10.3389/fmicb.2023.1282523	2023
	Coronin1A Regulates the Trafficking of Alpha Synuclein in Microglia.	Biggs KE, Fikse EN, Anderson FL, Kettenbach AN, Havrda MC.	J Neurosci	10.1523/jneurosci.1337-24.2025	2025
Enzymology	Kinetics of rapamycin production by Streptomyces hygroscopicus MTCC 4003.	Dutta S, Basak B, Bhunia B, Chakraborty S, Dey A.	3 Biotech	10.1007/s13205-013-0189-2	2014
	Integrated Metabolomic and Network Analysis to Explore the Potential Mechanism of Three Chemical Elicitors in Rapamycin Overproduction.	Zhang D, Chen J, Wang Z, Wang C.	Microorganisms	10.3390/microorganisms10112205	2022
	Rapamycin: Drug Repurposing in SARS-CoV-2 Infection.	Patocka J, Kuca K, Oleksak P, Nepovimova E, Valis M, Novotny M, Klimova B.	Pharmaceuticals (Basel)	10.3390/ph14030217	2021
Biotechnology	Current Approaches for Genetic Manipulation of Streptomyces spp.-Key Bacteria for Biotechnology and Environment.	Krysenko S.	BioTech (Basel)	10.3390/biotech14010003	2025
	Quantitative Morphological Analysis of Filamentous Microorganisms in Cocultures and Monocultures: Aspergillus terreus and Streptomyces rimosus Warfare in Bioreactors.	Scigaczewska A, Boruta T, Bizukojc M.	Biomolecules	10.3390/biom11111740	2021
Pathogenicity	Transcriptomic profiling reveals histone acetylation-regulated genes involved in somatic embryogenesis in Arabidopsis thaliana.	Wojcikowska B, Chwialkowska K, Nowak K, Citerne S, Moronczyk J, Wojcik AM, Kiwior-Wesolowska A, Francikowski J, Kwasniewski M, Gaj MD.	BMC Genomics	10.1186/s12864-024-10623-5	2024
	In Silico Strategy for Targeting the mTOR Kinase at Rapamycin Binding Site by Small Molecules.	Vittorio S, Gitto R, Adornato I, Russo E, De Luca L.	Molecules	10.3390/molecules26041103	2021
	Intravitreal sirolimus for persistent, exudative age-related macular degeneration: a Pilot Study.	Minturn RJ, Bracha P, Klein MJ, Chhablani J, Harless AM, Maturi RK.	Int J Retina Vitreous	10.1186/s40942-021-00281-0	2021
	Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators.	Skrzypczak N, Pyta K, Ruszkowski P, Mikolajczak P, Kucinska M, Murias M, Gdaniec M, Bartl F, Przybylski P.	J Enzyme Inhib Med Chem	10.1080/14756366.2021.1960829	2021
Enzymology	Thermal stability and conformational changes of transglutaminase from a newly isolated Streptomyces hygroscopicus.	Cui L, Du G, Zhang D, Chen J.	Bioresour Technol	10.1016/j.biortech.2007.07.017	2008
	Small and Equipped: the Rich Repertoire of Antibiotic Resistance Genes in Candidate Phyla Radiation Genomes.	Maatouk M, Ibrahim A, Rolain JM, Merhej V, Bittar F.	mSystems	10.1128/msystems.00898-21	2021
	[Identification of the gene encoding transglutaminase zymogen from Streptomyces hygroscopicus and its expression in Escherichia coli].	Ren Z, Zhang D, Yu M, Zhao Q, Du G, Chen J, Wu J.	Wei Sheng Wu Xue Bao		2008
	Late-stage diversification of bacterial natural products through biocatalysis.	Lazic J, Filipovic V, Pantelic L, Milovanovic J, Vojnovic S, Nikodinovic-Runic J.	Front Bioeng Biotechnol	10.3389/fbioe.2024.1351583	2024
Metabolism	The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997.	He W, Lei J, Liu Y, Wang Y.	Arch Microbiol	10.1007/s00203-007-0346-2	2008
Metabolism	[Improvement on the activity of microbial transglutaminase with Streptomyces hygroscopicus by the addition of surfactant CTAB].	Cheng L, Zhang DX, Du GC, Chen J.	Sheng Wu Gong Cheng Xue Bao		2007
	Everolimus versus sirolimus for angiomyolipoma associated with tuberous sclerosis complex: a multi-institutional retrospective study in China.	Luo C, Zhang YS, Zhang MX, Chen MF, Li Y, Qi L, Li HZ, Zu XB, Cai Y.	Orphanet J Rare Dis	10.1186/s13023-021-01932-z	2021
Metabolism	Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization.	Zhu X, Zhang W, Chen X, Wu H, Duan Y, Xu Z.	Biotechnol Bioeng	10.1002/bit.22819	2010
	Activated Carbon for Drug Delivery from Composite Biomaterials: The Effect of Grinding on Sirolimus Binding and Release.	Nazarkina ZK, Savostyanova TA, Chelobanov BP, Romanova IV, Simonov PA, Kvon RI, Karpenko AA, Laktionov PP.	Pharmaceutics	10.3390/pharmaceutics14071386	2022
Pathogenicity	Biomaterials Functionalized with Inflammasome Inhibitors-Premises and Perspectives.	Vinteler N, Feurdean CN, Petkes R, Barabas R, Bosca BA, Muntean A, Festila D, Ilea A.	J Funct Biomater	10.3390/jfb15020032	2024
	Endophytic Fungal and Bacterial Microbiota Shift in Rice and Barnyardgrass Grown under Co-Culture Condition.	Li S, Yan Q, Wang J, Peng Q.	Plants (Basel)	10.3390/plants11121592	2022
	Target of Rapamycin Regulates Photosynthesis and Cell Growth in Auxenochlorella pyrenoidosa.	Zhu T, Li L, Chang H, Zhan J, Ren M.	Int J Mol Sci	10.3390/ijms231911309	2022
	Purification and characterization of transglutaminase from a newly isolated Streptomyces hygroscopicus	Cui L, Du G, Zhang D, Liu H, Chen J.	Food Chem	10.1016/j.foodchem.2007.04.020	2007
	A masked, placebo-controlled, randomized clinical trial evaluating safety and the effect on cardiac function of low-dose rapamycin in 17 healthy client-owned dogs.	Barnett BG, Wesselowski SR, Gordon SG, Saunders AB, Promislow DEL, Schwartz SM, Chou L, Evans JB, Kaeberlein M, Creevy KE.	Front Vet Sci	10.3389/fvets.2023.1168711	2023
Metabolism	Rapamycin protects heart from ischemia/reperfusion injury independent of autophagy by activating PI3 kinase-Akt pathway and mitochondria K(ATP) channel.	Yang SS, Liu YB, Yu JB, Fan Y, Tang SY, Duan WT, Wang Z, Gan RT, Yu B.	Pharmazie		2010
	Antimicrobial activity of Streptomyces spp. isolated from Apis dorsata combs against some phytopathogenic bacteria.	Promnuan Y, Promsai S, Meelai S.	PeerJ	10.7717/peerj.10512	2020
Metabolism	Production of FK520 by Streptomyces tubercidicus.	Konya A, Szabo Z, Lang I, Barta I, Salat J.	Microbiol Res	10.1016/j.micres.2006.10.002	2008
Pathogenicity	Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion.	Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R.	Front Pharmacol	10.3389/fphar.2019.00323	2019
	Identification and Characterization of a New Regulator, TagR, for Environmental Stress Resistance Based on the DNA Methylome of Streptomyces roseosporus.	Gao WL, Fang JL, Zhu CY, Xu WF, Lyu ZY, Chan XA, Zhao QW, Li YQ.	Microbiol Spectr	10.1128/spectrum.00380-23	2023
Metabolism	Overexpression of the chitosanase gene in Fusarium solani via Agrobacterium tumefaciens-mediated transformation.	Liu H, Bao X.	Curr Microbiol	10.1007/s00284-008-9334-2	2009
Metabolism	Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A.	Garcia-Salcedo R, Alvarez-Alvarez R, Olano C, Canedo L, Brana AF, Mendez C, de la Calle F, Salas JA.	Mar Drugs	10.3390/md16080259	2018
	Review Update on the Life Cycle, Plant-Microbe Interaction, Genomics, Detection and Control Strategies of the Oil Palm Pathogen Ganoderma boninense.	Bharudin I, Ab Wahab AFF, Abd Samad MA, Xin Yie N, Zairun MA, Abu Bakar FD, Abdul Murad AM.	Biology (Basel)	10.3390/biology11020251	2022
Metabolism	Pterocidin, a cytotoxic compound from the endophytic Streptomyces hygroscopicus.	Igarashi Y, Miura SS, Fujita T, Furumai T.	J Antibiot (Tokyo)	10.1038/ja.2006.28	2006
	Transgene Was Silenced in Hybrids between Transgenic Herbicide-Resistant Crops and Their Wild Relatives Utilizing Alien Chromosomes.	Shao Z, Huang L, Zhang Y, Qiang S, Song X.	Plants (Basel)	10.3390/plants11233187	2022
	The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights.	Xiang Q, Zhao Y, Lin J, Jiang S, Li W.	Exp Mol Med	10.1038/s12276-022-00829-6	2022
	Acetylation is required for full activation of the NLRP3 inflammasome.	Zhang Y, Luo L, Xu X, Wu J, Wang F, Lu Y, Zhang N, Ding Y, Lu B, Zhao K.	Nat Commun	10.1038/s41467-023-44203-0	2023
	Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRalpha-Positive Breast Cancer.	Zhang J, Hu J, Li W, Zhang C, Su P, Wang Y, Sun W, Wang X, Li L, Wu X.	Front Oncol	10.3389/fonc.2021.608570	2021
Metabolism	Biosynthesis and Characterization of Extracellular Silver Nanoparticles from Streptomyces aizuneusis: Antimicrobial, Anti Larval, and Anticancer Activities.	Abd-Elhady HM, Ashor MA, Hazem A, Saleh FM, Selim S, El Nahhas N, Abdel-Hafez SH, Sayed S, Hassan EA.	Molecules	10.3390/molecules27010212	2021
	Collaborative trial validation studies of real-time PCR-based GMO screening methods for detection of the bar gene and the ctp2-cp4epsps construct.	Grohmann L, Brunen-Nieweler C, Nemeth A, Waiblinger HU.	J Agric Food Chem	10.1021/jf901598r	2009
	The mTOR inhibitor rapamycin suppresses trigeminal neuropathic pain and p-MKK4/p-p38 mitogen-activated protein kinase-mediated microglial activation in the trigeminal nucleus caudalis of mice with infraorbital nerve injury.	Yeo JH, Roh DH.	Front Mol Neurosci	10.3389/fnmol.2023.1172366	2023
	Actinomycetes from the Red Sea Sponge Coscinoderma mathewsi: Isolation, Diversity, and Potential for Bioactive Compounds Discovery.	Shamikh YI, El Shamy AA, Gaber Y, Abdelmohsen UR, Madkour HA, Madkour HA, Horn H, Hassan HM, Elmaidomy AH, Alkhalifah DHM, Hozzein WN.	Microorganisms	10.3390/microorganisms8050783	2020
Metabolism	Isolation, identification and characterization of Streptomyces metabolites as a potential bioherbicide.	Bo AB, Kim JD, Kim YS, Sin HT, Kim HJ, Khaitov B, Ko YK, Park KW, Choi JS.	PLoS One	10.1371/journal.pone.0222933	2019
	[Analysis of geldanamycin analogues in trace amounts by LC-MS/MS].	Ni S, Zhang K, Wang Y, He W, Wang Y, He J, Wu L.	Sheng Wu Gong Cheng Xue Bao		2009
Metabolism	Generation of high-yield rapamycin-producing strains through protoplasts-related techniques.	Chen X, Wei P, Fan L, Yang D, Zhu X, Shen W, Xu Z, Cen P.	Appl Microbiol Biotechnol	10.1007/s00253-009-1918-7	2009
Pathogenicity	Trichostatin A Promotes the Conversion of Astrocytes to Oligodendrocyte Progenitors in a Defined Culture Medium.	Zare L, Baharvand H, Javan M.	Iran J Pharm Res		2019
	Alvespimycin Exhibits Potential Anti-TGF-beta Signaling in the Setting of a Proteasome Activator in Rats with Bleomycin-Induced Pulmonary Fibrosis: A Promising Novel Approach.	Mohammed OA, Abdel-Reheim MA, Saleh LA, Alamri MMS, Alfaifi J, Adam MIE, Farrag AA, AlQahtani AAJ, BinAfif WF, Hashish AA, Abdel-Ghany S, Elmorsy EA, El-Wakeel HS, Doghish AS, Hamad RS, Saber S.	Pharmaceuticals (Basel)	10.3390/ph16081123	2023
	Combination of nigericin with cisplatin enhances the inhibitory effect of cisplatin on epithelial ovarian cancer metastasis by inhibiting slug expression via the Wnt/beta-catenin signalling pathway.	Zhou B, Wang C, Liu X, Wu B, Li J, Yao S, Zhang S.	Oncol Lett	10.3892/ol.2021.12961	2021
Metabolism	Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997.	He W, Wu L, Gao Q, Du Y, Wang Y.	Curr Microbiol	10.1007/s00284-005-0203-y	2006
	Evaluation of NMU-Induced Breast Cancer Treated with Sirolimus and Sunitinib on Breast Cancer Growth.	Jaffar NFN, Muhammad Sakri MS, Jaafar H, Wan Abdul Rahman WF, Tengku Din TADA.	Asian Pac J Cancer Prev	10.31557/apjcp.2020.21.10.2919	2020
	Cognitive Impairment in Multiple Sclerosis.	Maiese K.	Bioengineering (Basel)	10.3390/bioengineering10070871	2023
Metabolism	Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells.	Ho J, Wickramasinghe DN, Nikou SA, Hube B, Richardson JP, Naglik JR.	Cells	10.3390/cells9030699	2020
	Rapamycin Promotes the Expansion of Myeloid Cells by Increasing G-CSF Expression in Mesenchymal Stem Cells.	Li M, Lan Y, Gao J, Yuan S, Hou S, Guo T, Zhao F, Wang Y, Yuan W, Wang X.	Front Cell Dev Biol	10.3389/fcell.2022.779159	2022
	Everolimus-associated Acute Kidney Injury in Patients with Metastatic Breast Cancer.	Chandra A, Rao NS, Malhotra KP, Rastogi M, Khurana R.	Indian J Nephrol	10.4103/ijn.ijn_304_16	2017
	New insights into tuberous sclerosis complex: from structure to pathogenesis.	Chen CS, Aylett CHS.	Front Cell Dev Biol	10.3389/fcell.2025.1595867	2025
	A new geldanamycin analogue from Streptomyces hygroscopicus.	Zhang H, Sun GZ, Li X, Pan HY, Zhang YS.	Molecules	10.3390/molecules15031161	2010
	Heat Shock Protein 70 and 90 Family in Prostate Cancer.	Fu X, Liu J, Yan X, DiSanto ME, Zhang X.	Life (Basel)	10.3390/life12101489	2022
	Development of a qualitative, multiplex real-time PCR kit for screening of genetically modified organisms (GMOs).	Dorries HH, Remus I, Gronewald A, Gronewald C, Berghof-Jager K.	Anal Bioanal Chem	10.1007/s00216-009-3149-2	2010
Metabolism	[Regulatory genes of geldanamycin biosynthesis].	He W, Lei J, Liu Y, Wang Y.	Sheng Wu Gong Cheng Xue Bao	10.1016/s1872-2075(08)60036-9	2008
Pathogenicity	Oxazinomycin arrests RNA polymerase at the polythymidine sequences.	Prajapati RK, Rosenqvist P, Palmu K, Makinen JJ, Malinen AM, Virta P, Metsa-Ketela M, Belogurov GA.	Nucleic Acids Res	10.1093/nar/gkz782	2019
	Role of the Microbiota in Skin Neoplasms: New Therapeutic Horizons.	Savoia P, Azzimonti B, Rolla R, Zavattaro E.	Microorganisms	10.3390/microorganisms11102386	2023
	Molecular Screening for Nigericin Treatment in Pancreatic Cancer by High-Throughput RNA Sequencing.	Xu Z, Gao G, Liu F, Han Y, Dai C, Wang S, Wei G, Kuang Y, Wan D, Zhi Q, Xu Y.	Front Oncol	10.3389/fonc.2020.01282	2020
	Research Progress of Natural Active Substances with Immunosuppressive Activity.	Shao F, Shen Q, Yang Z, Yang W, Lu Z, Zheng J, Zhang L, Li H.	Molecules	10.3390/molecules29102359	2024
Pathogenicity	Molecular Mechanism of Overcoming Host Resistance by the Target of Rapamycin Gene in Leptographium qinlingensis.	An H, Gan T, Tang M, Chen H.	Microorganisms	10.3390/microorganisms10030503	2022
Phylogeny	Phosphonates as Unique Components of Plant Seeds-A Promising Approach to Use Phosphorus Profiles in Plant Chemotaxonomy.	Wieczorek D, Zyszka-Haberecht B, Kafka A, Lipok J.	Int J Mol Sci	10.3390/ijms222111501	2021
Enzymology	Hygrocins a and B, naphthoquinone macrolides from Streptomyces hygroscopicus.	Cai P, Kong F, Ruppen ME, Glasier G, Carter GT.	J Nat Prod	10.1021/np050272l	2005
	Rapamycin inhibits proliferation and apoptosis of retinoblastoma cells through PI3K/AKT signaling pathway.	Yao J, Xu M, Liu Z.	Oncol Lett	10.3892/ol.2020.11363	2020
	The Central FacilitaTOR: Coordinating Transcription and Translation in Eukaryotes.	Adams-Brown SE, Reid KZ.	Int J Mol Sci	10.3390/ijms26072845	2025
	ISPRF: a machine learning model to predict the immune subtype of kidney cancer samples by four genes.	Wang Z, Chen Z, Zhao H, Lin H, Wang J, Wang N, Li X, Ding D.	Transl Androl Urol	10.21037/tau-21-650	2021
	An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis.	Tahanzadeh N, Knop M, Seidler Y, Dirndorfer S, Lursen K, Bruchhaus I, Lang R, Rimbach G, Roeder T.	Aging (Albany NY)	10.18632/aging.204218	2022
Metabolism	A high-throughput method for screening of rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates.	Xu ZN, Shen WH, Chen XY, Lin JP, Cen PL.	Biotechnol Lett	10.1007/s10529-005-8463-y	2005
	Exploring the Potentiality of Native Actinobacteria to Combat the Chilli Fruit Rot Pathogens under Post-Harvest Pathosystem.	Renuka R, Prabakar K, Anandham R, Pugalendhi L, Rajendran L, Raguchander T, Karthikeyan G.	Life (Basel)	10.3390/life13020426	2023
	Rapamycin inhibits AR signaling pathway in prostate cancer by interacting with the FK1 domain of FKBP51.	Zhang J, Wu D, He Y, Li L, Liu S, Lu J, Gui H, Wang Y, Tao Y, Wang H, Kaushik D, Rodriguez R, Wang Z.	Biochem Biophys Rep	10.1016/j.bbrep.2020.100778	2020
Metabolism	Identification of genes necessary for jinggangmycin biosynthesis from Streptomyces hygroscopicus 10-22.	Jian X, Pang X, Yu Y, Zhou X, Deng Z.	Antonie Van Leeuwenhoek	10.1007/s10482-006-9058-x	2006
Phylogeny	The Streptomyces violaceusniger clade: a home for Streptomycetes with rugose ornamented spores.	Goodfellow M, Kumar Y, Labeda DP, Sembiring L.	Antonie Van Leeuwenhoek	10.1007/s10482-007-9146-6	2007
	Sirolimus for treatment of kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon.	Alaqeel AM, Alfurayh NA, Alhedyani AA, Alajlan SM.	JAAD Case Rep	10.1016/j.jdcr.2016.06.005	2016
	Rapamycin Alleviates the Symptoms of Multiple Sclerosis in Experimental Autoimmune Encephalomyelitis (EAE) Through Mediating the TAM-TLRs-SOCS Pathway.	Li XL, Zhang B, Liu W, Sun MJ, Zhang YL, Liu H, Wang MX.	Front Neurol	10.3389/fneur.2020.590884	2020
	Dynamic Modeling Using Artificial Neural Network of Bacillus Velezensis Broth Cross-Flow Microfiltration Enhanced by Air-Sparging and Turbulence Promoter.	Jokic A, Pajcin I, Grahovac J, Lukic N, Ikonic B, Nikolic N, Vlajkov V.	Membranes (Basel)	10.3390/membranes10120372	2020
Genetics	Efficient Multiplex Genome Editing in Streptomyces via Engineered CRISPR-Cas12a Systems.	Zhang J, Zhang D, Zhu J, Liu H, Liang S, Luo Y.	Front Bioeng Biotechnol	10.3389/fbioe.2020.00726	2020
	Natural Products Extracted from Fungal Species as New Potential Anti-Cancer Drugs: A Structure-Based Drug Repurposing Approach Targeting HDAC7.	Maruca A, Rocca R, Catalano R, Mesiti F, Costa G, Lanzillotta D, Salatino A, Ortuso F, Trapasso F, Alcaro S, Artese A.	Molecules	10.3390/molecules25235524	2020
	The impact of Schiff bases on antibiotic production by Streptomyces hygroscopicus.	Ilic SB, Konstantinovic SS, Savic DS, Veljkovic VB, Gojgic-Cvijovic G.	Med Chem Res	10.1007/s00044-009-9223-7	2010
	cvhA gene of Streptomyces hygroscopicus 10-22 encodes a negative regulator for mycelia development.	Wang HA, Qin L, Lu P, Pang ZX, Deng ZX, Zhao GP.	Acta Biochim Biophys Sin (Shanghai)	10.1111/j.1745-7270.2006.00160.x	2006
Metabolism	[Cloning and analysis of geldanamycin partial biosynthetic gene cluster of Streptomyces hygroscopicus 17997].	He WQ, Wang YG.	Sheng Wu Gong Cheng Xue Bao	10.1016/s1872-2075(06)60063-0	2006
	The molecular mechanisms of quality difference for Alpine Qingming green tea and Guyu green tea by integrating multi-omics.	Xiao H, Yong J, Xie Y, Zhou H.	Front Nutr	10.3389/fnut.2022.1079325	2022
	Streptomyces Levis ABRIINW111 Inhibits SW480 Cells Growth by Apoptosis Induction.	Faramarzian Azimi Maragheh B, Fatourachi P, Mohammadi SM, Valipour B, Behtari M, Dehnad A, Nozad Charoudeh H.	Adv Pharm Bull	10.15171/apb.2018.076	2018
	Expanding the genetic toolbox for Cutaneotrichosporon oleaginosus employing newly identified promoters and a novel antibiotic resistance marker.	Stellner NI, Rerop ZS, Mehlmer N, Masri M, Ringel M, Bruck TB.	BMC Biotechnol	10.1186/s12896-023-00812-7	2023
Metabolism	Effects of nutrients on the production of AK-111-81 macrolide antibiotic by Streptomyces hygroscopicus.	Gesheva V, Ivanova V, Gesheva R.	Microbiol Res	10.1016/j.micres.2004.06.005	2005
Pathogenicity	Reduced restenosis and enhanced re-endothelialization of functional biodegradable vascular scaffolds by everolimus and magnesium hydroxide.	Baek SW, Kim DS, Song DH, Kim HB, Lee S, Kim JH, Lee JK, Hong YJ, Park CG, Han DK.	Biomater Res	10.1186/s40824-022-00334-x	2022
Metabolism	[MTOR inhibitors: from transplantation to oncology. AFU 2006 Transplantation Committee Review of the literature].	Neuzillet Y, Karam G, Lechevallier E, Kleinclauss F, Comite Transplantation de l'Association Francaise d'Urologie.	Prog Urol	10.1016/s1166-7087(07)92390-8	2007
	Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer.	Seto B.	Clin Transl Med	10.1186/2001-1326-1-29	2012
Enzymology	Production of 8-demethylgeldanamycin and 4,5-epoxy-8-demethylgeldanamycin from a recombinant strain of Streptomyces hygroscopicus.	Buchanan GO, Regentin R, Piagentini M, Rascher A, McDaniel R, Galazzo JL, Licari PJ.	J Nat Prod	10.1021/np0496744	2005
	Biological and Chemical Diversity of Bacteria Associated with a Marine Flatworm.	Lin HN, Wang KL, Wu ZH, Tian RM, Liu GZ, Xu Y.	Mar Drugs	10.3390/md15090281	2017
Metabolism	Taxonomic distribution of Streptomyces species capable of producing bioactive compounds among strains preserved at NITE/NBRC.	Anzai K, Ohno M, Nakashima T, Kuwahara N, Suzuki R, Tamura T, Komaki H, Miyadoh S, Harayama S, Ando K.	Appl Microbiol Biotechnol	10.1007/s00253-008-1510-6	2008
	Overproduction of pro-transglutaminase from Streptomyces hygroscopicus in Yarrowia lipolytica and its biochemical characterization.	Liu S, Wan D, Wang M, Madzak C, Du G, Chen J.	BMC Biotechnol	10.1186/s12896-015-0193-1	2015
	Secondary Metabolites of Actinomycetales as Potent Quorum Sensing Inhibitors Targeting Gram-Positive Pathogens: In Vitro and In Silico Study.	Desouky SE, Abu-Elghait M, Fayed EA, Selim S, Yousuf B, Igarashi Y, Abdel-Wahab BA, Mohammed Alsuhaibani A, Sonomoto K, Nakayama J.	Metabolites	10.3390/metabo12030246	2022
Genetics	Targeted genetic manipulation and yeast-like evolutionary genomics in the green alga Auxenochlorella.	Craig RJ, Duenas MA, Camacho DJ, Gallaher SD, Avendano-Monsalve MC, Lin YT, Blaby-Haas CE, Moseley JL, Merchant SS.	Plant Cell	10.1093/plcell/koaf259	2025
	Identification and Heterologous Expression of the Kendomycin B Biosynthetic Gene Cluster from Verrucosispora sp. SCSIO 07399.	Chen J, Zhang S, Chen Y, Tian X, Gu Y, Ju J.	Mar Drugs	10.3390/md19120673	2021
	Contemporary Use of Drug-Coated Balloons for Coronary Angioplasty: A Comprehensive Review.	Verde N, Ciliberti G, Pittorino L, Ferrone M, Franzese M, Russo M, Cioppa A, Popusoi G, Salemme L, Tesorio T, Di Gioia G.	J Clin Med	10.3390/jcm13206243	2024
Metabolism	Discovery of Three New Phytotoxins from the Fungus Aspergillus nidulans by Pathway Inactivation.	Liao L, Zhang X, Lou Y, Zhou C, Yuan Q, Gao J.	Molecules	10.3390/molecules24030515	2019
	Research progress on the mechanism of glycolysis in ovarian cancer.	Li C, Liu FY, Shen Y, Tian Y, Han FJ.	Front Immunol	10.3389/fimmu.2023.1284853	2023
	Immune Responses of Asian Seabass Lates calcarifer to Dietary Glycyrrhiza uralensis.	Yang R, Han M, Fu Z, Wang Y, Zhao W, Yu G, Ma Z.	Animals (Basel)	10.3390/ani10091629	2020
	[Characterization and antimicrobial activity of the bioactive metabolites in streptomycete isolates].	Ilic SB, Konstantinovic SS, Todorovic ZB, Lazic ML, Veljkovic VB, Jokovic N, Radovanovic BC.	Mikrobiologiia	10.1134/s0026261707040066	2007
	Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry.	Kitson RRA, Kitsonova D, Siegel D, Ross D, Moody CJ.	J Med Chem	10.1021/acs.jmedchem.4c01048	2024
	A rat model for retinitis pigmentosa with rapid retinal degeneration enables drug evaluation in vivo.	Inoue C, Takeuchi T, Shiota A, Kondo M, Nshizawa Y.	Biol Proced Online	10.1186/s12575-021-00150-y	2021
	Diversity, mechanisms and beneficial features of phosphate-solubilizing Streptomyces in sustainable agriculture: A review.	Chouyia FE, Ventorino V, Pepe O.	Front Plant Sci	10.3389/fpls.2022.1035358	2022
	Biosynthesis and Metabolic Engineering of Pseudo-oligosaccharides.	Alanzi AR, Demessie AA, Mahmud T.	Emerg Top Life Sci	10.1042/etls20180010	2018
Enzymology	Amides from Streptomyces hygroscopicus and their antimicrobial activity [corrected].	Hossain MS, Hossain MA, Rahman MM, Mondol MA, Bhuiyan MS, Gray AI, Flores ME, Rashid MA.	Phytochemistry	10.1016/j.phytochem.2004.06.010	2004
	Morphological quantification of pellets in Streptomyces hygroscopicus var. geldanus fermentation broths using a flatbed scanner.	O'Cleirigh C, Walsh PK, O'Shea DG.	Biotechnol Lett	10.1023/a:1025622100475	2003
	Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application.	Schiffelers LDJ, Tesfamariam YM, Jenster LM, Diehl S, Binder SC, Normann S, Mayr J, Pritzl S, Hagelauer E, Kopp A, Alon A, Geyer M, Ploegh HL, Schmidt FI.	Nat Commun	10.1038/s41467-024-52110-1	2024
Pathogenicity	Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells.	Lin X, Han L, Weng J, Wang K, Chen T.	Biosci Rep	10.1042/bsr20181822	2018
	Fungal-fungal cocultivation leads to widespread secondary metabolite alteration requiring the partial loss-of-function VeA1 protein.	Wang G, Ran H, Fan J, Keller NP, Liu Z, Wu F, Yin WB.	Sci Adv	10.1126/sciadv.abo6094	2022
	In search of autophagy biomarkers in breast cancer: Receptor status and drug agnostic transcriptional changes during autophagy flux in cell lines.	Mascia F, Mazo I, Alterovitz WL, Karagiannis K, Wu WW, Shen RF, Beaver JA, Rao VA.	PLoS One	10.1371/journal.pone.0262134	2022
	Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity.	Martinovic A, Mantovani M, Trpchevska N, Novak E, Milev NB, Bode L, Ewald CY, Bischof E, Reichmuth T, Lapides R, Navarini A, Saravi B, Roider E.	Front Aging	10.3389/fragi.2024.1495029	2024
Metabolism	Heterologous Expression of Recombinant Transglutaminase in Bacillus subtilis SCK6 with Optimized Signal Peptide and Codon, and Its Impact on Gelatin Properties.	Wang S, Yang Z, Li Z, Tian Y.	J Microbiol Biotechnol	10.4014/jmb.2002.02049	2020
	Analysis of the Genetic Stability of Insect and Herbicide Resistance Genes in Transgenic Rice Lines: A Laboratory and Field Experiment.	Sun Y, Chen Z, Chen H, Wang C, Li B, Qin L, Lin X, Cai Y, Zhou D, Ouyang L, Zhu C, He H, Peng X.	Rice (N Y)	10.1186/s12284-023-00624-5	2023
	Enhanced growth and beta-galactosidase production on Escherichia coli using oxygen vectors.	Ciobanu CP, Blaga AC, Froidevaux R, Krier F, Galaction AI, Cascaval D.	3 Biotech	10.1007/s13205-020-02284-4	2020
	Evaluation of Streptomyces saraciticas as Soil Amendments for Controlling Soil-Borne Plant Pathogens.	Wu PH, Tsay TT, Chen P.	Plant Pathol J	10.5423/ppj.oa.08.2021.0131	2021
	Direct Delivery of Health Promoting beta-Asp-Arg Dipeptides via Stable Co-expression of Cyanophycin and the Cyanophycinase CphE241 in Tobacco Plants.	Nausch H, Dorn M, Frolov A, Hoedtke S, Wolf P, Broer I.	Front Plant Sci	10.3389/fpls.2020.00842	2020
Enzymology	A codon-optimized bacterial antibiotic gene used as selection marker for stable nuclear transformation in the marine red alga Pyropia yezoensis.	Uji T, Hirata R, Fukuda S, Mizuta H, Saga N.	Mar Biotechnol (NY)	10.1007/s10126-013-9549-5	2014
	Expression of gamma-globin genes in beta-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin).	Zuccato C, Cosenza LC, Zurlo M, Gasparello J, Papi C, D'Aversa E, Breveglieri G, Lampronti I, Finotti A, Borgatti M, Scapoli C, Stievano A, Fortini M, Ramazzotti E, Marchetti N, Prosdocimi M, Gamberini MR, Gambari R.	Ther Adv Hematol	10.1177/20406207221100648	2022
	Reconstruction and Exploratory Analysis of mTORC1 Signaling Pathway and Its Applications to Various Diseases Using Network-Based Approach.	Buddham R, Chauhan S, Narad P, Mathur P.	J Microbiol Biotechnol	10.4014/jmb.2108.08007	2022
Metabolism	Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy.	Gan L, Ren Y, Lu J, Ma J, Shen X, Zhuang Z.	Onco Targets Ther	10.2147/ott.s273108	2020
Genetics	Macromolecular Structure of Linearly Arranged Eukaryotic Chromosomes.	Banfalvi G.	Int J Mol Sci	10.3390/ijms23169503	2022
	Gemcitabine and Selected mTOR Inhibitors in Uterine Sarcomas and Carcinosarcoma Cells- an Isobolographic Analysis.	Bobinski M, Okla K, Luszczki J, Bednarek W, Wawruszak A, Moreno-Bueno G, Garcia-Sanz P, Dmoszynska-Graniczka M, Tarkowski R, Kotarski J.	Int J Med Sci	10.7150/ijms.48187	2020
Metabolism	Inhibitors of HSP90 in melanoma.	Mielczarek-Lewandowska A, Hartman ML, Czyz M.	Apoptosis	10.1007/s10495-019-01577-1	2020
	Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease.	Ren Q, Sun Q, Fu J.	Autophagy	10.1080/15548627.2023.2254191	2024
	Facial angiofibromas of tuberous sclerosis treated with topical sirolimus in an Indian patient.	Vasani RJ.	Indian J Dermatol	10.4103/0019-5154.152516	2015
Genetics	The Postmedieval Latvian Oral Microbiome in the Context of Modern Dental Calculus and Modern Dental Plaque Microbial Profiles.	Kazarina A, Petersone-Gordina E, Kimsis J, Kuzmicka J, Zayakin P, Griskjans Z, Gerhards G, Ranka R.	Genes (Basel)	10.3390/genes12020309	2021
	Simultaneous Measurement of Changes in Neutrophil Granulocyte Membrane Potential, Intracellular pH, and Cell Size by Multiparametric Flow Cytometry.	Stratmann AEP, Wohlgemuth L, Erber ME, Bernhard S, Hug S, Fauler M, Vidoni L, Mohamed AOK, Thomass BD, Munnich F, Stukan L, Fohr KJ, Mannes M, Huber-Lang MS, Messerer DAC.	Biomedicines	10.3390/biomedicines9111504	2021
	IP3R1 regulates Ca²⁺ transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury.	Mo G, Liu X, Zhong Y, Mo J, Li Z, Li D, Zhang L, Liu Y.	Cell Death Discov	10.1038/s41420-021-00404-4	2021
	Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging.	Flores IO, Trevino S, Diaz A.	Neural Regen Res	10.4103/1673-5374.331867	2023
	Isolation and purification of antibacterial compound from Streptomyces levis collected from soil sample of north India.	Singh V, Haque S, Khare S, Tiwari AK, Katiyar D, Banerjee B, Kumari K, Tripathi CKM.	PLoS One	10.1371/journal.pone.0200500	2018
	Modification of Medium Composition for Enhancing the Production of Antifungal Activity from Xenorhabdus stockiae PB09 by Using Response Surface Methodology.	Sa-Uth C, Rattanasena P, Chandrapatya A, Bussaman P.	Int J Microbiol	10.1155/2018/3965851	2018
	Clethramycin, a new inhibitor of pollen tube growth with antifungal activity from Streptomyces hygroscopicus TP-A0623. I. Screening, taxonomy, fermentation, isolation and biological properties.	Furumai T, Yamakawa T, Yoshida R, Igarashi Y.	J Antibiot (Tokyo)	10.7164/antibiotics.56.700	2003
	mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis.	Palma JA, Martinez J, Millar Vernetti P, Ma T, Perez MA, Zhong J, Qian Y, Dutta S, Maina KN, Siddique I, Bitan G, Ades-Aron B, Shepherd TM, Kang UJ, Kaufmann H.	Mov Disord	10.1002/mds.28923	2022
	The mTOR Signaling Pathway in Multiple Sclerosis; from Animal Models to Human Data.	Vakrakou AG, Alexaki A, Brinia ME, Anagnostouli M, Stefanis L, Stathopoulos P.	Int J Mol Sci	10.3390/ijms23158077	2022
	Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma.	Orozco Morales ML, Rinaldi CA, de Jong E, Lansley SM, Lee YCG, Zemek RM, Bosco A, Lake RA, Lesterhuis WJ.	PLoS One	10.1371/journal.pone.0274364	2023
Metabolism	Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.	Khaledian B, Taguchi A, Shin-Ya K, Kondo-Ida L, Kagaya N, Suzuki M, Kajino T, Yamaguchi T, Shimada Y, Takahashi T.	Cancer Sci	10.1111/cas.14786	2021
	The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases.	Han X, Goh KY, Lee WX, Choy SM, Tang HW.	Int J Mol Sci	10.3390/ijms24010297	2022
	Samul-Tang Regulates Cell Cycle and Migration of Vascular Smooth Muscle Cells against TNF-alpha Stimulation.	Choi ES, Yoon JJ, Han BH, Jeong DH, Kim HY, Ahn YM, Eun SY, Lee YJ, Kang DG, Lee HS.	Evid Based Complement Alternat Med	10.1155/2018/1024974	2018
Metabolism	Ester antibiotic accumulation by Streptomyces hygroscopicus.	Bhattacharyya BK, Sen SK.	New Microbiol		2002
	Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets.	Yu PC, Huang CH, Kuo CJ, Liang PH, Wang LH, Pan MY, Chang SY, Chao TL, Ieong SM, Fang JT, Huang HC, Juan HF.	Pharmaceutics	10.3390/pharmaceutics14010176	2022
Phylogeny	Characterization of Yuhushiella sp. TD-032 from the Thar Desert and its antimicrobial activity.	Ibeyaima A, Rana J, Dwivedi A, Gupta S, Sharma SK, Saini N, Sarethy IP.	J Adv Pharm Technol Res	10.4103/2231-4040.177201	2016
	A selective antibiotic for Lyme disease.	Leimer N, Wu X, Imai Y, Morrissette M, Pitt N, Favre-Godal Q, Iinishi A, Jain S, Caboni M, Leus IV, Bonifay V, Niles S, Bargabos R, Ghiglieri M, Corsetti R, Krumpoch M, Fox G, Son S, Klepacki D, Polikanov YS, Freliech CA, McCarthy JE, Edmondson DG, Norris SJ, D'Onofrio A, Hu LT, Zgurskaya HI, Lewis K.	Cell	10.1016/j.cell.2021.09.011	2021
Pathogenicity	Herbicidal inhibitors of amino acid biosynthesis and herbicide-tolerant crops.	Tan S, Evans R, Singh B.	Amino Acids	10.1007/s00726-005-0254-1	2006
Metabolism	Advances in engineered microorganisms for improving metabolic conversion via microgravity effects.	Huangfu J, Zhang G, Li J, Li C.	Bioengineered	10.1080/21655979.2015.1056942	2015
Metabolism	Production of ansamycin polyketide precursors in Escherichia coli.	Rude MA, Khosla C.	J Antibiot (Tokyo)	10.1038/ja.2006.65	2006
	Regulation of CD8⁺ T memory and exhaustion by the mTOR signals.	Chen Y, Xu Z, Sun H, Ouyang X, Han Y, Yu H, Wu N, Xie Y, Su B.	Cell Mol Immunol	10.1038/s41423-023-01064-3	2023
	Exploration of Microbial Factories for Synthesis of Nanoparticles - A Sustainable Approach for Bioremediation of Environmental Contaminants.	Kapoor RT, Salvadori MR, Rafatullah M, Siddiqui MR, Khan MA, Alshareef SA.	Front Microbiol	10.3389/fmicb.2021.658294	2021
Pathogenicity	[The role of caspase-3 in rapamycin-induced apoptosis of hepatocellular carcinoma BEL-7402 cells].	Zhang JF, Lu MQ, Cai CJ, Yang Y, Li H, Yi HM, Chen GH.	Ai Zheng		2006
	From an Hsp90 - binding protein to a peptide drug.	Ammanath AV, Jarneborn A, Nguyen MT, Wessling L, Tribelli P, Nega M, Beck C, Luqman A, Selim KA, Kalbacher H, Macek B, Hammer SB, Jin T, Gotz F.	Microlife	10.1093/femsml/uqac023	2023
Metabolism	Metabolic pathways mediate pathogenesis and offer targets for treatment in rheumatic diseases.	Wyman B, Perl A.	Curr Opin Rheumatol	10.1097/bor.0000000000000687	2020
Metabolism	Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium Streptomyces lohii.	Li Z, Li S, Du L, Zhang X, Jiang Y, Liu W, Zhang W, Li S.	Mar Drugs	10.3390/md19010029	2021
	Deciphering Molecular Aspects of Potential alpha-Glucosidase Inhibitors within Aspergillus terreus: A Computational Odyssey of Molecular Docking-Coupled Dynamics Simulations and Pharmacokinetic Profiling.	Elhady SS, Alshobaki NM, Elfaky MA, Koshak AE, Alharbi M, Abdelhameed RFA, Darwish KM.	Metabolites	10.3390/metabo13080942	2023
	Rethinking of the Roles of Endophyte Symbiosis and Mycotoxin in Oxytropis Plants.	Guan H, Liu X, Mur LAJ, Fu Y, Wei Y, Wang J, He W.	J Fungi (Basel)	10.3390/jof7050400	2021
Genetics	H₂O₂-Based Method for Rapid Detection of Transgene-Free Rice Plants from Segregating CRISPR/Cas9 Genome-Edited Progenies.	Wu TM, Huang JZ, Oung HM, Hsu YT, Tsai YC, Hong CY.	Int J Mol Sci	10.3390/ijms20163885	2019
Pathogenicity	From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?	Cypryk W, Nyman TA, Matikainen S.	Front Immunol	10.3389/fimmu.2018.02188	2018
	In vitro evaluation of antimicrobial and antibiofilm potentials of silver nanoparticles biosynthesised by Streptomyces griseorubens	Baygar T, Ugur A.	IET Nanobiotechnol		2017
Metabolism	Corynebacterium glutamicum as platform for the production of hydroxybenzoic acids.	Kallscheuer N, Marienhagen J.	Microb Cell Fact	10.1186/s12934-018-0923-x	2018
	Histone Deacetylase Inhibitors: A Prospect in Drug Discovery.	Yadav R, Mishra P, Yadav D.	Turk J Pharm Sci	10.4274/tjps.75047	2019
	Mining and fine-tuning sugar uptake system for titer improvement of milbemycins in Streptomyces bingchenggensis.	Jin P, Li S, Zhang Y, Chu L, He H, Dong Z, Xiang W.	Synth Syst Biotechnol	10.1016/j.synbio.2020.07.001	2020
	Overview and detectability of the genetic modifications in ornamental plants.	Boutigny AL, Dohin N, Pornin D, Rolland M.	Hortic Res	10.1038/s41438-019-0232-5	2020
	Effect of Oxidation on Quality of Chiba Tofu Produced by Soy Isolate Protein When Subjected to Storage.	Xu Y, Wang Z, Qi B, Ran A, Guo Z, Jiang L.	Foods	10.3390/foods9121877	2020
Pathogenicity	Reserpine improves Enterobacteriaceae resistance in chicken intestine via neuro-immunometabolic signaling and MEK1/2 activation.	Redweik GAJ, Kogut MH, Arsenault RJ, Lyte M, Mellata M.	Commun Biol	10.1038/s42003-021-02888-3	2021
	Differentiation Potential of Nestin (+) and Nestin (-) Cells Derived from Human Bone Marrow Mesenchymal Stem Cells into Functional Insulin Producing Cells.	Rashed S, Gabr M, Abdel-Aziz AA, Zakaria M, Khater S, Ismail A, Fouad A, Refaie A.	Int J Mol Cell Med	10.22088/ijmcm.bums.8.1.1	2019
Metabolism	Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1beta Maturation and ASC Speck Formation in Macrophages.	Mishra N, Schwerdtner L, Sams K, Mondal S, Ahmad F, Schmidt RE, Coonrod SA, Thompson PR, Lerch MM, Bossaller L.	J Immunol	10.4049/jimmunol.1800720	2019
	[Rapamycine and mTOR inhibitors: from bench to bedside].	Pallet N, Beaune P, Legendre C, Anglicheau D.	Ann Biol Clin (Paris)		2006
Pathogenicity	The role of the mTOR pathway in diabetic retinopathy.	Casciano F, Zauli E, Rimondi E, Mura M, Previati M, Busin M, Zauli G.	Front Med (Lausanne)	10.3389/fmed.2022.973856	2022
Metabolism	Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.	Eichner S, Eichner T, Floss HG, Fohrer J, Hofer E, Sasse F, Zeilinger C, Kirschning A.	J Am Chem Soc	10.1021/ja2087147	2012
	Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications.	Salete-Granado D, Carbonell C, Puertas-Miranda D, Vega-Rodriguez VJ, Garcia-Macia M, Herrero AB, Marcos M.	Antioxidants (Basel)	10.3390/antiox12071425	2023
	SCRaMbLE: A Study of Its Robustness and Challenges through Enhancement of Hygromycin B Resistance in a Semi-Synthetic Yeast.	Ong JY, Swidah R, Monti M, Schindler D, Dai J, Cai Y.	Bioengineering (Basel)	10.3390/bioengineering8030042	2021
	Sirolimus-Eluting Electrospun-Produced Matrices as Coatings for Vascular Stents: Dependence of Drug Release on Matrix Structure and Composition of the External Environment.	Nazarkina ZK, Chelobanov BP, Chernonosova VS, Romanova IV, Karpenko AA, Laktionov PP.	Materials (Basel)	10.3390/ma13122692	2020
	An engineered Streptomyces hygroscopicus aph 7" gene mediates dominant resistance against hygromycin B in Chlamydomonas reinhardtii.	Berthold P, Schmitt R, Mages W.	Protist	10.1078/14344610260450136	2002
	Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish.	Feng N, Bian Z, Zhang X, Wang C, Chen J.	Singapore Med J	10.11622/smedj.2018132	2019
Enzymology	Structure of a sedoheptulose 7-phosphate cyclase: ValA from Streptomyces hygroscopicus.	Kean KM, Codding SJ, Asamizu S, Mahmud T, Karplus PA.	Biochemistry	10.1021/bi5003508	2014
	Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis.	Lee HE, Yang G, Park YB, Kang HC, Cho YY, Lee HS, Lee JY.	Molecules	10.3390/molecules24112138	2019
	Effectiveness of inhibitor rapamycin, saracatinib, linsitinib and JNJ-38877605 against human prostate cancer cells.	Li W, Wang Z, Wang L, He X, Wang G, Liu H, Guo F, Wang Z, Chen G.	Int J Clin Exp Med		2015
	Systemic Actions of SGLT2 Inhibition on Chronic mTOR Activation as a Shared Pathogenic Mechanism between Alzheimer's Disease and Diabetes.	Stanciu GD, Rusu RN, Bild V, Filipiuc LE, Tamba BI, Ababei DC.	Biomedicines	10.3390/biomedicines9050576	2021
Enzymology	Current state and future perspectives of cytochrome P450 enzymes for C-H and C=C oxygenation.	Yan Y, Wu J, Hu G, Gao C, Guo L, Chen X, Liu L, Song W.	Synth Syst Biotechnol	10.1016/j.synbio.2022.04.009	2022
	Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease.	Zhao R, Zhu M, Zhou S, Feng W, Chen H.	Front Chem	10.3389/fchem.2020.00407	2020
Pathogenicity	Study of Antibacterial and Anticancer Properties of bioAgNPs Synthesized Using Streptomyces sp. PBD-311B and the Application of bioAgNP-CNC/Alg as an Antibacterial Hydrogel Film against P. aeruginosa USM-AR2 and MRSA.	Murugaiah H, Teh CL, Loh KC, Mohamad Yahya AR, Md Noh NA, Abu Bakar NHH, Kernain D, Hashim R, Bustami Y.	Molecules	10.3390/molecules26216414	2021
Metabolism	Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro.	Zhang JF, Liu JJ, Lu MQ, Cai CJ, Yang Y, Li H, Xu C, Chen GH.	Transpl Immunol	10.1016/j.trim.2006.12.003	2007
	Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue.	Ikegami K, Yamashita M, Suzuki M, Nakamura T, Hashimoto K, Kitagaki J, Yanagita M, Kitamura M, Murakami S.	Aging (Albany NY)	10.18632/aging.204569	2023
Pathogenicity	Preparation and study of two kinds of ophthalmic nano-preparations of everolimus.	Tang Z, Yin L, Zhang Y, Yu W, Wang Q, Zhan Z.	Drug Deliv	10.1080/10717544.2019.1692966	2019
Genetics	Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters.	Sulheim S, Fossheim FA, Wentzel A, Almaas E.	BMC Bioinformatics	10.1186/s12859-021-03985-0	2021
	Everolimus-associated stomatitis in a patient who had renal transplant.	Ji YD, Aboalela A, Villa A.	BMJ Case Rep	10.1136/bcr-2016-217513	2016
Genetics	A linear plasmid temperature-sensitive for replication in Streptomyces hygroscopicus 10-22.	Pang X, Sun Y, Liu J, Zhou X, Deng Z.	FEMS Microbiol Lett	10.1111/j.1574-6968.2002.tb11055.x	2002
	Phosphomannose isomerase, pmi, as a selectable marker gene for durum wheat transformation	Gadaleta A, Giancaspro A, Blechl A, Blanco A.	J Cereal Sci	10.1016/j.jcs.2005.06.004	2006
	Leucine aminopeptidase from Streptomyces hygroscopicus is controlled by a low molecular weight inhibitor.	Karadzic I, Izrael L, Gojgic-Cvijovic G, Vujcic Z.	J Biosci Bioeng	10.1263/jbb.94.309	2002
	Sirolimus-induced bronchiolitis obliterans organizing pneumonia in a kidney transplant recipient; a case report and review of literature.	Einollahi B, Einollahi B, Aslani J, Taghipour M, Motalebi M, Karimi-Sari H.	J Nephropathol	10.12860/jnp.2014.21	2014
	Rapamycin Ameliorates Radiation-Induced Testis Damage in Mice.	Yang J, Xu R, Luan Y, Fan H, Yang S, Liu J, Zeng H, Shao L.	Front Cell Dev Biol	10.3389/fcell.2022.783884	2022
	Investigation of horizontal gene transfer in poplar/Amanita muscaria ectomycorrhizas.	Zhang C, Hampp R, Nehls U.	Environ Biosafety Res	10.1051/ebr:2006004	2005
	Compositional analysis of soybean event IND-ØØ41Ø-5.	Chiozza MV, Burachik M, Miranda PV.	GM Crops Food	10.1080/21645698.2020.1742040	2020
	Concentration-dependent effects of rapamycin on proliferation, migration and apoptosis of endothelial cells in human venous malformation.	Si Y, Chu H, Zhu W, Xiao T, Shen X, Fu Y, Xu R, Jiang H.	Exp Ther Med	10.3892/etm.2018.6782	2018
Pathogenicity	Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling.	Li Y, Romey-Glusing R, Tahan Zadeh N, von Frieling J, Hoffmann J, Huebbe P, Bruchhaus I, Rimbach G, Fink C, Roeder T.	Nutrients	10.3390/nu12041172	2020
	Extracted metabolite from Streptomyces Levis ABRIINW111 altered the gene expression in colon cancer.	Fatourachi P, Faramarziyan Azimi Maragheh B, Mohammadi SM, Valipour B, Dehnad A, Nozad Charoudeh H.	Gastroenterol Hepatol Bed Bench		2018
Pathogenicity	Mannopeptimycins, a novel class of glycopeptide antibiotics active against gram-positive bacteria.	He H.	Appl Microbiol Biotechnol	10.1007/s00253-004-1884-z	2005
	Histone Deacetylase Inhibitor Trichostatin A Reduces Endothelial Cell Proliferation by Suppressing STAT5A-Related Gene Transcription.	Li Y, Zhao Y, Peng H, Zhang J, Bo L, Wen L, Liu W, Bai W, Zhang H.	Front Oncol	10.3389/fonc.2021.746266	2021
	Antibiotic pigment from desert soil actinomycetes; biological activity, purification and chemical screening.	Selvameenal L, Radhakrishnan M, Balagurunathan R.	Indian J Pharm Sci	10.4103/0250-474x.58174	2009
Pathogenicity	Effects of geldanamycin on hatching and juvenile motility in Caenorhabditis elegans and Heterodera glycines.	Skantar AM, Agama K, Meyer SL, Carta LK, Vinyard BT.	J Chem Ecol	10.1007/s10886-005-7114-z	2005
Genetics	Efficient genome editing and gene knockout in Setaria viridis with CRISPR/Cas9 directed gene editing by the non-homologous end-joining pathway.	Basso MF, Duarte KE, Santiago TR, de Souza WR, Garcia BO, da Cunha BDB, Kobayashi AK, Molinari HBC.	Plant Biotechnol (Tokyo)	10.5511/plantbiotechnology.21.0407a	2021
	mTOR Signaling in Kidney Diseases.	Gui Y, Dai C.	Kidney360	10.34067/kid.0003782020	2020
	New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164.	Fan Y, Wang C, Wang L, Chairoungdua A, Piyachaturawat P, Fu P, Zhu W.	Mar Drugs	10.3390/md16080282	2018
Metabolism	Development and Validation of a Bioanalytical LC-MS/MS Method for Simultaneous Determination of Sirolimus in Porcine Whole Blood and Lung Tissue and Pharmacokinetic Application with Coronary Stents.	Nguyen TT, Duong VA, Vo DK, Jo J, Maeng HJ.	Molecules	10.3390/molecules26020425	2021
Pathogenicity	Crosstalk between Autophagy and Inflammatory Processes in Cancer.	Lee EJ, Kim HJ, Choi MS, Chang JE.	Life (Basel)	10.3390/life11090903	2021
	Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non-mTOR-mediated etiologies.	Cepeda C, Levinson S, Yazon VW, Barry J, Mathern GW, Fallah A, Vinters HV, Levine MS, Wu JY.	Epilepsia Open	10.1002/epi4.12253	2018
	Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes.	Hong H, Samborskyy M, Usachova K, Schnatz K, Leadlay PF.	Beilstein J Org Chem	10.3762/bjoc.13.238	2017
Metabolism	Production of a novel FK520 analog in Streptomyces hygroscopicus: improving titer while minimizing impurities.	Regentin R, Cadapan L, Ou S, Zavala S, Licari P.	J Ind Microbiol Biotechnol	10.1038/sj/jim/7000208	2002
Enzymology	pH-dependent activation of Streptomyces hygroscopicus transglutaminase mediated by intein.	Du K, Liu Z, Cui W, Zhou L, Liu Y, Du G, Chen J, Zhou Z.	Appl Environ Microbiol	10.1128/aem.02820-13	2014
Enzymology	Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.	Schorn M, Zettler J, Noel JP, Dorrestein PC, Moore BS, Kaysser L.	ACS Chem Biol	10.1021/cb400699p	2014
	Reduction in Phosphoribulokinase Amount and Re-Routing Metabolism in Chlamydomonas reinhardtii CP12 Mutants.	Gerard C, Lebrun R, Lemesle E, Avilan L, Chang KS, Jin E, Carriere F, Gontero B, Launay H.	Int J Mol Sci	10.3390/ijms23052710	2022
Pathogenicity	Development of a robust microtiter plate-based assay method for assessment of bioactivity.	Casey JT, O'Cleirigh C, Walsh PK, O'Shea DG.	J Microbiol Methods	10.1016/j.mimet.2004.04.017	2004
Metabolism	[Establishment of gene transduction system in geldanamycin producer - Streptomyces hygroscopicus 17997 and its application for gene disruption experiment].	Gao HY, Wang YG, Gao QJ, Shang GD, Sun GZ, Yang Y.	Sheng Wu Gong Cheng Xue Bao		2003
	Structural basis of DNA binding by the WhiB-like transcription factor WhiB3 in Mycobacterium tuberculosis.	Wan T, Horova M, Khetrapal V, Li S, Jones C, Schacht A, Sun X, Zhang L.	J Biol Chem	10.1016/j.jbc.2023.104777	2023
Phylogeny	Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis.	Labeda DP, Dunlap CA, Rong X, Huang Y, Doroghazi JR, Ju KS, Metcalf WW.	Antonie Van Leeuwenhoek	10.1007/s10482-016-0824-0	2017
	The impact of immunosuppressant therapy on the recurrence of hepatitis C post-liver transplantation.	Albekairy AM, Abdel-Razaq WS, Alkatheri AM, Debasi TMA, Otaibi NEA, Qandil AM.	Int J Health Sci (Qassim)		2018
Genetics	Genome rearrangements and megaplasmid loss in the filamentous bacterium Kitasatospora viridifaciens are associated with protoplast formation and regeneration.	Ramijan K, Zhang Z, van Wezel GP, Claessen D.	Antonie Van Leeuwenhoek	10.1007/s10482-020-01393-7	2020
Metabolism	Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import.	Filipuzzi I, Steffen J, Germain M, Goepfert L, Conti MA, Potting C, Cerino R, Pfeifer M, Krastel P, Hoepfner D, Bastien J, Koehler CM, Helliwell SB.	Nat Chem Biol	10.1038/nchembio.2493	2017
Metabolism	Isolation and characterization of novel geldanamycin analogues.	Hu Z, Liu Y, Tian ZQ, Ma W, Starks CM, Regentin R, Licari P, Myles DC, Hutchinson CR.	J Antibiot (Tokyo)	10.7164/antibiotics.57.421	2004
Pathogenicity	Effect of 5-Aza-2'-Deoxycytidine in Comparison to Valproic Acid and Trichostatin A on Histone Deacetylase 1, DNA Methyltransferase 1, and CIP/KIP Family (p21, p27, and p57) Genes Expression, Cell Growth Inhibition, and Apoptosis Induction in Colon Cancer SW480 Cell Line.	Sanaei M, Kavoosi F.	Adv Biomed Res	10.4103/abr.abr_91_19	2019
	mTOR Signaling Components in Tumor Mechanobiology.	Gargalionis AN, Papavassiliou KA, Basdra EK, Papavassiliou AG.	Int J Mol Sci	10.3390/ijms23031825	2022
	LmbU, a Cluster-Situated Regulator for Lincomycin, Consists of a DNA-Binding Domain, an Auto-Inhibitory Domain, and Forms Homodimer.	Hou B, Zhu X, Kang Y, Wang R, Wu H, Ye J, Zhang H.	Front Microbiol	10.3389/fmicb.2019.00989	2019
	Artificial intelligence in microbial natural product drug discovery: current and emerging role.	Sahayasheela VJ, Lankadasari MB, Dan VM, Dastager SG, Pandian GN, Sugiyama H.	Nat Prod Rep	10.1039/d2np00035k	2022
	Polaramycin B, and not physical interaction, is the signal that rewires fungal metabolism in the Streptomyces-Aspergillus interaction.	Berger H, Bacher M, Labuda R, Eppel IM, Bayer F, Sulyok M, Gasparotto E, Zehetbauer F, Doppler M, Gratzl H, Strauss J.	Environ Microbiol	10.1111/1462-2920.16118	2022
	Optimization and Pharmacokinetic Evaluation of Synergistic Fenbendazole and Rapamycin Co-Encapsulated in Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles.	Shin HJ, Jo MJ, Jin IS, Park CW, Kim JS, Shin DH.	Int J Nanomedicine	10.2147/ijn.s315782	2021
Metabolism	Biosynthesis of Silver Nanoparticles by Streptomyces griseorubens isolated from Soil and Their Antioxidant Activity.	Baygar T, Ugur A.	IET Nanobiotechnol	10.1049/iet-nbt.2015.0127	2017
Enzymology	Pentalenolactone I and hygromycin A, immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus.	Uyeda M, Mizukami M, Yokomizo K, Suzuki K.	Biosci Biotechnol Biochem	10.1271/bbb.65.1252	2001
	mTOR-Dependent Cell Proliferation in the Brain.	Ryskalin L, Lazzeri G, Flaibani M, Biagioni F, Gambardella S, Frati A, Fornai F.	Biomed Res Int	10.1155/2017/7082696	2017
	Mannopeptimycins, novel antibacterial glycopeptides from Streptomyces hygroscopicus, LL-AC98.	He H, Williamson RT, Shen B, Graziani EI, Yang HY, Sakya SM, Petersen PJ, Carter GT.	J Am Chem Soc	10.1021/ja020257s	2002
Pathogenicity	Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury.	Zhou Q, Doherty J, Akk A, Springer LE, Fan P, Spasojevic I, Halade GV, Yang H, Pham CTN, Wickline SA, Pan H.	Nanomaterials (Basel)	10.3390/nano12030336	2022
	Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.	Patel K, Piagentini M, Rascher A, Tian ZQ, Buchanan GO, Regentin R, Hu Z, Hutchinson CR, McDaniel R.	Chem Biol	10.1016/j.chembiol.2004.09.012	2004
Metabolism	Deletion of rapQONML from the rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog.	Chung L, Liu L, Patel S, Carney JR, Reeves CD.	J Antibiot (Tokyo)	10.7164/antibiotics.54.250	2001
Phylogeny	NAT/NCS2-hound: a webserver for the detection and evolutionary classification of prokaryotic and eukaryotic nucleobase-cation symporters of the NAT/NCS2 family.	Chaliotis A, Vlastaridis P, Ntountoumi C, Botou M, Yalelis V, Lazou P, Tatsaki E, Mossialos D, Frillingos S, Amoutzias GD.	Gigascience	10.1093/gigascience/giy133	2018
Metabolism	Mutagenesis of the rapamycin producer Streptomyces hygroscopicus FC904.	Cheng YR, Huang J, Qiang H, Lin WL, Demain AL.	J Antibiot (Tokyo)	10.7164/antibiotics.54.967	2001
Genetics	Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture.	Kim JH, Lee N, Hwang S, Kim W, Lee Y, Cho S, Palsson BO, Cho BK.	J Ind Microbiol Biotechnol	10.1093/jimb/kuaa001	2021
Metabolism	A new substrate specificity for acyl transferase domains of the ascomycin polyketide synthase in Streptomyces hygroscopicus.	Reeves CD, Chung LM, Liu Y, Xue Q, Carney JR, Revill WP, Katz L.	J Biol Chem	10.1074/jbc.m111915200	2002
	The Potential of Streptomyces as Biocontrol Agents against the Rice Blast Fungus, Magnaporthe oryzae (Pyricularia oryzae).	Law JW, Ser HL, Khan TM, Chuah LH, Pusparajah P, Chan KG, Goh BH, Lee LH.	Front Microbiol	10.3389/fmicb.2017.00003	2017
	The chaperone system in cancer therapies: Hsp90.	Basset CA, Conway de Macario E, Leone LG, Macario AJL, Leone A.	J Mol Histol	10.1007/s10735-023-10119-8	2023
Pathogenicity	Pyroptosis-Mediated Periodontal Disease.	Sordi MB, Magini RS, Panahipour L, Gruber R.	Int J Mol Sci	10.3390/ijms23010372	2021
Metabolism	Dissolution of the Disparate: Co-ordinate Regulation in Antibiotic Biosynthesis.	McLean TC, Wilkinson B, Hutchings MI, Devine R.	Antibiotics (Basel)	10.3390/antibiotics8020083	2019
Proteome	Phosphoproteome Dynamics of Streptomyces rimosus during Submerged Growth and Antibiotic Production.	Saric E, Quinn GA, Nalpas N, Paradzik T, Kazazic S, Filic Z, Semanjski M, Herron P, Hunter I, Macek B, Vujaklija D.	mSystems	10.1128/msystems.00199-22	2022
	Bacterial-fungal interactions under agricultural settings: from physical to chemical interactions.	Zhou Y, Wang H, Xu S, Liu K, Qi H, Wang M, Chen X, Berg G, Ma Z, Cernava T, Chen Y.	Stress Biol	10.1007/s44154-022-00046-1	2022
	Morinagadepsin, a Depsipeptide from the Fungus Morinagamyces vermicularis gen. et comb. nov.	Harms K, Surup F, Stadler M, Stchigel AM, Marin-Felix Y.	Microorganisms	10.3390/microorganisms9061191	2021
	[Calcium ions and the differentiation of Streptomyces hygroscopicus 155, a producer of an antibiotic complex].	Moncheva PA, Danova ST, Gocheva Ia, Ivanova IV.	Antibiot Khimioter		2000
	Novel sulfur-containing rapamycin analogs prepared by precursor-directed biosynthesis.	Graziani EI, Ritacco FV, Summers MY, Zabriskie TM, Yu K, Bernan VS, Greenstein M, Carter GT.	Org Lett	10.1021/ol034591k	2003
Metabolism	Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae.	Rodriguez E, Ward S, Fu H, Revill WP, McDaniel R, Katz L.	Appl Microbiol Biotechnol	10.1007/s00253-004-1658-7	2004
	Anti-tumor activity of WK88-1, a novel geldanamycin derivative, in gefitinib-resistant non-small cell lung cancers with Met amplification.	Jang WJ, Jung SK, Kang JS, Jeong JW, Bae MK, Joo SH, Park GH, Kundu JK, Hong YS, Jeong CH.	Cancer Sci	10.1111/cas.12497	2014
	The target of rapamycin signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity in Aspergillus flavus.	Li G, Cao X, Tumukunde E, Zeng Q, Wang S.	Elife	10.7554/elife.89478	2024
Metabolism	Molecular actions of sirolimus: sirolimus and mTor.	Kirken RA, Wang YL.	Transplant Proc	10.1016/s0041-1345(03)00230-6	2003
Metabolism	CRISPR-Cpf1-Assisted Multiplex Genome Editing and Transcriptional Repression in Streptomyces.	Li L, Li L, Wei K, Zheng G, Liu X, Chen S, Jiang W, Lu Y.	Appl Environ Microbiol	10.1128/aem.00827-18	2018
	Identification and expression of the gene encoding phosphonopyruvate decarboxylase of Streptomyces hygroscopicus.	Nakashita H, Kozuka K, Hidaka T, Hara O, Seto H.	Biochim Biophys Acta	10.1016/s0167-4781(99)00249-3	2000
	The actin gene promoter-driven bar as a dominant selectable marker for nuclear transformation of Dunaliella salina.	Jiang GZ, Lu YM, Niu XL, Xue LX.	Yi Chuan Xue Bao		2005
	Optofluidic detection setup for multi-parametric analysis of microbiological samples in droplets.	Hengoju S, Wohlfeil S, Munser AS, Boehme S, Beckert E, Shvydkiv O, Tovar M, Roth M, Rosenbaum MA.	Biomicrofluidics	10.1063/1.5139603	2020
Metabolism	Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence.	Mecca C, Giambanco I, Donato R, Arcuri C.	Dis Markers	10.1155/2018/9230479	2018
Metabolism	The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.	Wu K, Chung L, Revill WP, Katz L, Reeves CD.	Gene	10.1016/s0378-1119(00)00171-2	2000
	Salicylic acid fights against Fusarium wilt by inhibiting target of rapamycin signaling pathway in Fusarium oxysporum.	Li L, Zhu T, Song Y, Feng L, Kear PJ, Riseh RS, Sitohy M, Datla R, Ren M.	J Adv Res	10.1016/j.jare.2021.10.014	2022
	Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action.	Castro-Falcon G, Hahn D, Reimer D, Hughes CC.	ACS Chem Biol	10.1021/acschembio.5b00924	2016
Pathogenicity	Histone Deacetylase Inhibitor, Trichostatin A, Synergistically Enhances Paclitaxel-Induced Cytotoxicity in Urothelial Carcinoma Cells by Suppressing the ERK Pathway.	Hsu FS, Wu JT, Lin JY, Yang SP, Kuo KL, Lin WC, Shi CS, Chow PM, Liao SM, Pan CI, Hong JY, Chang HC, Huang KH.	Int J Mol Sci	10.3390/ijms20051162	2019
Enzymology	Homologous expression of Phanerochaete chrysosporium manganese peroxidase, using bialaphos resistance as a dominant selectable marker.	Ma B, Mayfield MB, Gold MH.	Curr Genet	10.1007/s00294-003-0418-z	2003
	Decreased Phosphorylated Protein Kinase B (Akt) in Individuals with Autism Associated with High Epidermal Growth Factor Receptor (EGFR) and Low Gamma-Aminobutyric Acid (GABA).	Russo AJ.	Biomark Insights	10.4137/bmi.s21946	2015
Pathogenicity	Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation.	Lin HC, Chen YJ, Wei YH, Lin HA, Chen CC, Liu TF, Hsieh YL, Huang KY, Lin KH, Wang HH, Chen LC.	Front Immunol	10.3389/fimmu.2021.630380	2021
	Targeted Next Generation Sequencing to study insert stability in genetically modified plants.	Boutigny AL, Barranger A, De Boisseson C, Blanchard Y, Rolland M.	Sci Rep	10.1038/s41598-019-38701-9	2019
	mTOR function and therapeutic targeting in breast cancer.	Hare SH, Harvey AJ.	Am J Cancer Res		2017
	Sirolimus: its discovery, biological properties, and mechanism of action.	Sehgal SN.	Transplant Proc	10.1016/s0041-1345(03)00211-2	2003
Phylogeny	Antimicrobial activity of bacteria isolated from Red Sea marine invertebrates.	El Samak M, Solyman SM, Hanora A.	Biotechnol Rep (Amst)	10.1016/j.btre.2018.e00275	2018
	Efficacy of amikacin combinations for nocardiosis.	Kanemitsu K, Kunishima H, Saga T, Harigae H, Ishikawa S, Takemura H, Kaku M.	Tohoku J Exp Med	10.1620/tjem.201.157	2003
Metabolism	Guanosine monophosphate synthase upregulation mediates cervical cancer progression by inhibiting the apoptosis of cervical cancer cells via the Stat3/P53 pathway.	Wang J, Wu Y, Li Y, Wang Y, Shen F, Zhou J, Chen Y.	Int J Oncol	10.3892/ijo.2021.5183	2021
	The Effect of Fluid Shear Stress on the In Vitro Release Kinetics of Sirolimus from PLGA Films.	Zheng Q, Chu Z, Li X, Kang H, Yang X, Fan Y.	Polymers (Basel)	10.3390/polym9110618	2017
	Effects of different straw returning amounts and fertilizer conditions on bacteria of rice's different part in rare earth mining area.	Jin S, Huang Y, Dong C, Bai Y, Pan H, Hu Z.	Sci Rep	10.1038/s41598-023-27553-z	2023
Pathogenicity	Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.	Strong R, Miller RA, Bogue M, Fernandez E, Javors MA, Libert S, Marinez PA, Murphy MP, Musi N, Nelson JF, Petrascheck M, Reifsnyder P, Richardson A, Salmon AB, Macchiarini F, Harrison DE.	Aging Cell	10.1111/acel.13269	2020
	Nanomaterials Enhance Pyroptosis-Based Tumor Immunotherapy.	Ji F, Shi C, Shu Z, Li Z.	Int J Nanomedicine	10.2147/ijn.s457309	2024
Metabolism	Quantitative Proteomics Reveals Changes Induced by TIMP-3 on Cell Membrane Composition and Novel Metalloprotease Substrates.	Carreca AP, Pravata VM, D'Apolito D, Bonelli S, Calligaris M, Monaca E, Muller SA, Lichtenthaler SF, Scilabra SD.	Int J Mol Sci	10.3390/ijms22052392	2021
Enzymology	Development and comparative study of a pat/bar real-time PCR assay for integrating the screening strategy of a GMO testing laboratory.	Verginelli D, Paterno A, De Marchis ML, Quarchioni C, Vinciguerra D, Bonini P, Peddis S, Fusco C, Misto M, Marfoglia C, Pomilio F, Marchesi U.	J Sci Food Agric	10.1002/jsfa.10235	2020
Pathogenicity	Non-specific activities of the major herbicide-resistance gene BAR.	Christ B, Hochstrasser R, Guyer L, Francisco R, Aubry S, Hortensteiner S, Weng JK.	Nat Plants	10.1038/s41477-017-0061-1	2017
Metabolism	The putative elaiophylin biosynthetic gene cluster in Streptomyces sp. DSM4137 is adjacent to genes encoding adenosylcobalamin-dependent methylmalonyl CoA mutase and to genes for synthesis of cobalamin.	Haydock SF, Mironenko T, Ghoorahoo HI, Leadlay PF.	J Biotechnol	10.1016/j.jbiotec.2004.03.022	2004
	The evolving experience using everolimus in clinical transplantation.	Formica RN, Lorber KM, Friedman AL, Bia MJ, Lakkis F, Smith JD, Lorber MI.	Transplant Proc	10.1016/j.transproceed.2004.01.015	2004
	Identification of a novel strain, Streptomyces blastmyceticus JZB130180, and evaluation of its biocontrol efficacy against Monilinia fructicola.	Ni M, Wu Q, Wang HL, Liu WC, Hu B, Zhang DP, Zhao J, Liu DW, Lu CG.	J Zhejiang Univ Sci B	10.1631/jzus.b1700609	2019
Metabolism	Changing oxidoreduction potential to improve water-soluble yellow pigment production with Monascus ruber CGMCC 10910.	Huang T, Tan H, Lu F, Chen G, Wu Z.	Microb Cell Fact	10.1186/s12934-017-0828-0	2017
	A reversed phase high performance liquid chromatographic method for determination of rapamycin.	Sobhani H, Shafaati A, Nafissi-Varcheh N, Aboofazeli R.	Iran J Pharm Res		2013
Metabolism	Cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum: effect of surfactants and organic solvents on activity.	Pollegioni L, Gadda G, Ambrosius D, Ghisla S, Pilone MS.	Biotechnol Appl Biochem	10.1111/j.1470-8744.1999.tb01155.x	1999
	Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches.	Ordonez-Robles M, Santos-Beneit F, Martin JF.	Antibiotics (Basel)	10.3390/antibiotics7020039	2018
	Benefit-risk assessment of sirolimus in renal transplantation.	Kuypers DR.	Drug Saf	10.2165/00002018-200528020-00006	2005
Metabolism	The promoter of a cold-shock-like gene has pleiotropic effects on Streptomyces antibiotic biosynthesis.	Martinez-Costa OH, Zalacain M, Holmes DJ, Malpartida F.	FEMS Microbiol Lett	10.1016/s0378-1097(03)00101-0	2003
Metabolism	Expression of a Streptomyces 3-hydroxysteroid oxidase gene in oilseeds for converting phytosterols to phytostanols.	Venkatramesh M, Karunanandaa B, Sun B, Gunter CA, Boddupalli S, Kishore GM.	Phytochemistry	10.1016/s0031-9422(02)00431-4	2003
Metabolism	ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.	Lee J, Kim J, Shin J, Kang Y, Choi J, Cheong H.	Int J Mol Sci	10.3390/ijms22179182	2021
Metabolism	The Production and Utilization of GDP-glucose in the Biosynthesis of Trehalose 6-Phosphate by Streptomyces venezuelae.	Asencion Diez MD, Miah F, Stevenson CE, Lawson DM, Iglesias AA, Bornemann S.	J Biol Chem	10.1074/jbc.m116.758664	2017
Enzymology	Kinetics of Synthesis of Gold Nanoparticles by Acinetobacter sp. SW30 Isolated from Environment.	Wadhwani SA, Shedbalkar UU, Singh R, Vashisth P, Pruthi V, Chopade BA.	Indian J Microbiol	10.1007/s12088-016-0598-0	2016
	The effect of rapamycin and its analogues on age-related musculoskeletal diseases: a systematic review.	Lin H, Salech F, Lim A, Vogrin S, Duque G.	Aging Clin Exp Res	10.1007/s40520-022-02190-0	2022
	Co-culture: stimulate the metabolic potential and explore the molecular diversity of natural products from microorganisms.	Peng XY, Wu JT, Shao CL, Li ZY, Chen M, Wang CY.	Mar Life Sci Technol	10.1007/s42995-020-00077-5	2021
Metabolism	Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion.	Delgoffe GM, Powell JD.	Mol Immunol	10.1016/j.molimm.2015.07.026	2015
Metabolism	Antifungal potential of extracellular metabolites produced by Streptomyces hygroscopicus against phytopathogenic fungi.	Prapagdee B, Kuekulvong C, Mongkolsuk S.	Int J Biol Sci	10.7150/ijbs.4.330	2008
Enzymology	Kinetic mechanisms of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum.	Pollegioni L, Wels G, Pilone MS, Ghisla S.	Eur J Biochem	10.1046/j.1432-1327.1999.00586.x	1999
	Sirolimus-based immunosuppression with reduce dose cyclosporine or tacrolimus after renal transplantation.	Formica RN, Lorber KM, Friedman AL, Bia MJ, Lakkis F, Smith JD, Lorber MI.	Transplant Proc	10.1016/s0041-1345(03)00216-1	2003
	Exploring Endophytic Fungi as Natural Antagonists against Fungal Pathogens of Food Crops.	Manathunga KK, Gunasekara NW, Meegahakumbura MK, Ratnaweera PB, Faraj TK, Wanasinghe DN.	J Fungi (Basel)	10.3390/jof10090606	2024
Pathogenicity	Drugs that target aging: how do we discover them?	Myers A, Lithgow GJ.	Expert Opin Drug Discov	10.1080/17460441.2019.1597049	2019
Pathogenicity	Sirolimus augments hematopoietic stem and progenitor cell regeneration following hematopoietic insults.	Lin Z, Hollinger MK, Wu Z, Sun W, Batey K, Kim J, Chen J, Feng X, Young NS.	Stem Cells	10.1002/stem.3313	2021
	It Takes Two to Tango: A Bacterial Biofilm Provides Protection against a Fungus-Feeding Bacterial Predator.	Sharma S, Compant S, Franken P, Ruppel S, Ballhausen MB.	Microorganisms	10.3390/microorganisms9081566	2021
Pathogenicity	Drug Candidates for Autoimmune Diseases.	Saurin S, Meineck M, Erkel G, Opatz T, Weinmann-Menke J, Pautz A.	Pharmaceuticals (Basel)	10.3390/ph15050503	2022
	Complete biosynthetic pathway to the antidiabetic drug acarbose.	Tsunoda T, Samadi A, Burade S, Mahmud T.	Nat Commun	10.1038/s41467-022-31232-4	2022
Genetics	Recent Advances in Synthetic Biology Approaches to Optimize Production of Bioactive Natural Products in Actinobacteria.	Li L, Li L, Liu X, Jiang W, Lu Y.	Front Microbiol	10.3389/fmicb.2019.02467	2019
	Rapamycin in cardiovascular medicine.	Ruygrok PN, Muller DW, Serruys PW.	Intern Med J	10.1046/j.1445-5994.2003.00331.x	2003
Genetics	Exploring the Potential of Antibiotic Production From Rare Actinobacteria by Whole-Genome Sequencing and Guided MS/MS Analysis.	Hu D, Sun C, Jin T, Fan G, Mok KM, Li K, Lee SM.	Front Microbiol	10.3389/fmicb.2020.01540	2020
Metabolism	Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition.	Lin HC, Chen YJ, Wei YH, Chuang YT, Hsieh SH, Hsieh JY, Hsieh YL, Ojcius DM, Huang KY, Chung IC, Yuan SN, Chang YS, Chen LC.	Int J Mol Sci	10.3390/ijms21145104	2020
	Evaluation of Biocontrol Activities of Streptomyces spp. against Rice Blast Disease Fungi.	Chaiharn M, Theantana T, Pathom-Aree W.	Pathogens	10.3390/pathogens9020126	2020
Metabolism	Acyltransferase AniI, a Tailoring Enzyme with Broad Substrate Tolerance for High-Level Production of Anisomycin.	Wang Q, Kong L, Zheng X, Shen J, Wang J, Zhang D, Qiao Y, Wang J, Deng Z, You D.	Appl Environ Microbiol	10.1128/aem.00172-21	2021
Enzymology	Structural and functional characterization of MppR, an enduracididine biosynthetic enzyme from streptomyces hygroscopicus: functional diversity in the acetoacetate decarboxylase-like superfamily.	Burroughs AM, Hoppe RW, Goebel NC, Sayyed BH, Voegtline TJ, Schwabacher AW, Zabriskie TM, Silvaggi NR.	Biochemistry	10.1021/bi400397k	2013
Metabolism	Biosynthesis of Ag, Se, and ZnO nanoparticles with antimicrobial activities against resistant pathogens using waste isolate Streptomyces enissocaesilis.	Shaaban M, El-Mahdy AM.	IET Nanobiotechnol	10.1049/iet-nbt.2017.0213	2018
	Characterization of female germline stem cells from adult mouse ovaries and the role of rapamycin on them.	Yang H, Yao X, Tang F, Wei Y, Hua J, Peng S.	Cytotechnology	10.1007/s10616-018-0196-6	2018
Metabolism	Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22.	Wang J, Yu Y, Tang K, Liu W, He X, Huang X, Deng Z.	Appl Environ Microbiol	10.1128/aem.01790-09	2010
Metabolism	Conserved biosynthetic pathways for phosalacine, bialaphos and newly discovered phosphonic acid natural products.	Blodgett JA, Zhang JK, Yu X, Metcalf WW.	J Antibiot (Tokyo)	10.1038/ja.2015.77	2016
Metabolism	Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.	Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B.	Proc Natl Acad Sci U S A	10.1073/pnas.1015773108	2011
Pathogenicity	Cadmium-Induced Cell Homeostasis Impairment is Suppressed by the Tor1 Deficiency in Fission Yeast.	Pozgajova M, Navratilova A, Sebova E, Kovar M, Kacaniova M.	Int J Mol Sci	10.3390/ijms21217847	2020
	Inhibition of NLRP3 inflammasome in tumor microenvironment leads to suppression of metastatic potential of cancer cells.	Lee HE, Lee JY, Yang G, Kang HC, Cho YY, Lee HS, Lee JY.	Sci Rep	10.1038/s41598-019-48794-x	2019
Metabolism	Genetically engineered production of 1,1'-bis-valienamine and validienamycin in Streptomyces hygroscopicus and their conversion to valienamine.	Xu H, Yang J, Bai L, Deng Z, Mahmud T.	Appl Microbiol Biotechnol	10.1007/s00253-008-1711-z	2009
	Molecular Docking studies of FKBP12-mTOR inhibitors using binding predictions.	Nasr AB, Ponnala D, Sagurthi SR, Kattamuri RK, Marri VK, Gudala S, Lakkaraju C, Bandaru S, Nayarisseri A.	Bioinformation	10.6026/97320630011307	2015
	Efficacy and safety of mTOR inhibitors (rapamycin and its analogues) for tuberous sclerosis complex: a meta-analysis.	Li M, Zhou Y, Chen C, Yang T, Zhou S, Chen S, Wu Y, Cui Y.	Orphanet J Rare Dis	10.1186/s13023-019-1012-x	2019
	Improved the expression level of active transglutaminase by directional increasing copy of mtg gene in Pichia pastoris.	Song X, Shao C, Guo Y, Wang Y, Cai J.	BMC Biotechnol	10.1186/s12896-019-0542-6	2019
	Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B.	Kato Y, Bai L, Xue Q, Revill WP, Yu TW, Floss HG.	J Am Chem Soc	10.1021/ja0127483	2002
Metabolism	Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity.	Barzilay E, Ben-Califa N, Supino-Rosin L, Kashman Y, Hirschberg K, Elazar Z, Neumann D.	J Biol Chem	10.1074/jbc.m312799200	2004
	HS1 Is Involved in Hygromycin Resistance Through Facilitating Hygromycin Phosphotransferase Transportation From Cytosol to Chloroplast.	Luo Y, Zhang L, Li W, Xu M, Zhang C, Wang L.	Front Plant Sci	10.3389/fpls.2020.00613	2020
Metabolism	[Glutamate oxalacetate and glutamate pyruvate aminotransferase activity in Streptomyces hygroscopicus 155 producing antibiotic complex].	Chipeva VA, Ivanova IV, Gocheva B.	Antibiot Khimioter		1997
Metabolism	Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism.	Amara A, Takano E, Breitling R.	BMC Genomics	10.1186/s12864-018-4905-5	2018
Metabolism	Growth of Steptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits rapamycin production.	Fang A, Pierson DL, Mishra SK, Demain AL.	Appl Microbiol Biotechnol	10.1007/s002539900303	2000
Metabolism	Gene Replacement for the Generation of Designed Novel Avermectin Derivatives with Enhanced Acaricidal and Nematicidal Activities.	Huang J, Chen AL, Zhang H, Yu Z, Li MH, Li N, Lin JT, Bai H, Wang JD, Zheng YG.	Appl Environ Microbiol	10.1128/aem.01025-15	2015
	Genetic improvement in Pleurotus (oyster mushroom): a review.	Barh A, Sharma VP, Annepu SK, Kamal S, Sharma S, Bhatt P.	3 Biotech	10.1007/s13205-019-1854-x	2019
Enzymology	Streptomycetes: Attractive Hosts for Recombinant Protein Production.	Berini F, Marinelli F, Binda E.	Front Microbiol	10.3389/fmicb.2020.01958	2020
	Expression of set is downregulated by rapamycin in human colorectal cancer cells.	Wen X, Chen Y.	Biomed Rep	10.3892/br.2013.133	2013
	Modern Approaches for the Development of New Herbicides Based on Natural Compounds.	Berestetskiy A.	Plants (Basel)	10.3390/plants12020234	2023
Metabolism	Auxin and Target of Rapamycin Spatiotemporally Regulate Root Organogenesis.	Xie X, Wang Y, Datla R, Ren M.	Int J Mol Sci	10.3390/ijms222111357	2021
	Transformation of three genera of orchid using the bar gene as a selectable marker.	Knapp JE, Kausch AP, Chandlee JM.	Plant Cell Rep	10.1007/s002990000202	2000
	Short open reading frame genes in innate immunity: from discovery to characterization.	Malekos E, Carpenter S.	Trends Immunol	10.1016/j.it.2022.07.005	2022
	The In Vitro Antimicrobial Susceptibility of Borrelia burgdorferi sensu lato: Shedding Light on the Known Unknowns.	Hunfeld KP, Kraiczy P, Norris DE, Lohr B.	Pathogens	10.3390/pathogens12101204	2023
	High-dose rapamycin exerts a temporary impact on T. reesei RUT-C30 through gene trFKBP12.	Pang AP, Wang H, Zhang F, Hu X, Wu FG, Zhou Z, Wang W, Lu Z, Lin F.	Biotechnol Biofuels	10.1186/s13068-021-01926-w	2021
Enzymology	Characterization of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum.	Gadda G, Wels G, Pollegioni L, Zucchelli S, Ambrosius D, Pilone MS, Ghisla S.	Eur J Biochem	10.1111/j.1432-1033.1997.0369a.x	1997
Pathogenicity	Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells After Transplantation into Infarcted Myocardium.	Li ZH, Wang YL, Wang HJ, Wu JH, Tan YZ.	Stem Cell Rev Rep	10.1007/s12015-020-09952-1	2020
Enzymology	Cloning, expression, and characterization of a type II 3-dehydroquinate dehydratase gene from Streptomyces hygroscopicus.	Florova G, Denoya CD, Morgenstern MR, Skinner DD, Reynolds KA.	Arch Biochem Biophys	10.1006/abbi.1997.0536	1998
Pathogenicity	A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90.	Palma LC, Ferreira LFGR, Petersen ALOA, Dias BRS, Menezes JPB, Moreira DRM, Hernandes MZ, Veras PST.	Sci Rep	10.1038/s41598-019-51239-0	2019
	Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+CD25+ Foxp3 regulatory T cells.	Yuan LF, Li GD, Ren XJ, Nian H, Li XR, Zhang XM.	Int J Ophthalmol	10.3980/j.issn.2222-3959.2015.04.03	2015
Metabolism	Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.	Arndt C, Cruz MC, Cardenas ME, Heitman J.	Microbiology (Reading)	10.1099/13500872-145-8-1989	1999
	Fatty acid composition of Streptomyces hygroscopicus strains producing antibiotics.	Gesheva V, Rachev R, Bojkova S.	Lett Appl Microbiol	10.1046/j.1472-765x.1997.00359.x	1997
Enzymology	Modulation of Gene Expression in Actinobacteria by Translational Modification of Transcriptional Factors and Secondary Metabolite Biosynthetic Enzymes.	Martin JF, Liras P, Sanchez S.	Front Microbiol	10.3389/fmicb.2021.630694	2021
	mTOR signaling and Alzheimer's disease: What we know and where we are?	Davoody S, Asgari Taei A, Khodabakhsh P, Dargahi L.	CNS Neurosci Ther	10.1111/cns.14463	2024
Metabolism	Effect of nitrogen source on biosynthesis of rapamycin by Streptomyces hygroscopicus.	Lee MS, Kojima I, Demain AL.	J Ind Microbiol Biotechnol	10.1038/sj.jim.2900434	1997
Pathogenicity	Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of rapamycin-p70S6 kinase in male rats.	Liu S, Huang L, Geng Y, He J, Chen X, Xu H, Li R, Wang Y, Ding Y, Liu X.	Mol Med Rep	10.3892/mmr.2017.7120	2017
Pathogenicity	Xylapeptide A, an Antibacterial Cyclopentapeptide with an Uncommon L-Pipecolinic Acid Moiety from the Associated Fungus Xylaria sp. (GDG-102).	Xu WF, Hou XM, Yao FH, Zheng N, Li J, Wang CY, Yang RY, Shao CL.	Sci Rep	10.1038/s41598-017-07331-4	2017
Metabolism	Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008.	Wu H, Qu S, Lu C, Zheng H, Zhou X, Bai L, Deng Z.	BMC Genomics	10.1186/1471-2164-13-337	2012
Pathogenicity	Nigericin Promotes NLRP3-Independent Bacterial Killing in Macrophages.	Armstrong H, Bording-Jorgensen M, Chan R, Wine E.	Front Immunol	10.3389/fimmu.2019.02296	2019
	Generating Heterokaryotic Cells via Bacterial Cell-Cell Fusion.	Shitut S, Shen MJ, Claushuis B, Derks RJE, Giera M, Rozen D, Claessen D, Kros A.	Microbiol Spectr	10.1128/spectrum.01693-22	2022
Transcriptome	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.	Xu Z, Shen J, Hua S, Wan D, Chen Q, Han Y, Ren R, Liu F, Du Z, Guo X, Shi J, Zhi Q.	BMC Genomics	10.1186/s12864-019-6032-3	2019
	Rapamycin-Loaded Lipid Nanocapsules Induce Selective Inhibition of the mTORC1-Signaling Pathway in Glioblastoma Cells.	Sehedic D, Roncali L, Djoudi A, Buchtova N, Avril S, Cherel M, Boury F, Lacoeuille F, Hindre F, Garcion E.	Front Bioeng Biotechnol	10.3389/fbioe.2020.602998	2020
	Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle.	Wang Y, Gallagher LA, Andrade PA, Liu A, Humphreys IR, Turkarslan S, Cutler KJ, Arrieta-Ortiz ML, Li Y, Radey MC, McLean JS, Cong Q, Baker D, Baliga NS, Peterson SB, Mougous JD.	Cell	10.1016/j.cell.2023.08.017	2023
	Resistance to the mTOR inhibitor everolimus is reversed by the downregulation of survivin in breast cancer cells.	Taglieri L, De Iuliis F, Giuffrida A, Giantulli S, Silvestri I, Scarpa S.	Oncol Lett	10.3892/ol.2017.6597	2017
	Autophagy Activation in Zebrafish Heart Regeneration.	Chavez MN, Morales RA, Lopez-Crisosto C, Roa JC, Allende ML, Lavandero S.	Sci Rep	10.1038/s41598-020-59106-z	2020
Pathogenicity	Plants rendered herbicide-susceptible by cauliflower mosaic virus-elicited suppression of a 35S promoter-regulated transgene.	Al-Kaff NS, Kreike MM, Covey SN, Pitcher R, Page AM, Dale PJ.	Nat Biotechnol	10.1038/79501	2000
	Biological Characteristics and Antimicrobial Activity of Endophytic Streptomyces sp. TQR12-4 Isolated from Elite Citrus nobilis Cultivar Ham Yen of Vietnam.	Hong-Thao PT, Mai-Linh NV, Hong-Lien NT, Van Hieu N.	Int J Microbiol	10.1155/2016/7207818	2016
	Development and validation of an HPLC method for the analysis of sirolimus in drug products.	Islambulchilar Z, Ghanbarzadeh S, Emami S, Valizadeh H, Zakeri-Milani P.	Adv Pharm Bull	10.5681/apb.2012.021	2012
	TOR kinase, a GPS in the complex nutrient and hormonal signaling networks to guide plant growth and development.	Meng Y, Zhang N, Li J, Shen X, Sheen J, Xiong Y.	J Exp Bot	10.1093/jxb/erac282	2022
Enzymology	A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain.	Ruan X, Stassi D, Lax SA, Katz L.	Gene	10.1016/s0378-1119(97)00450-2	1997
Metabolism	Arsinothricin, an arsenic-containing non-proteinogenic amino acid analog of glutamate, is a broad-spectrum antibiotic.	Nadar VS, Chen J, Dheeman DS, Galvan AE, Yoshinaga-Sakurai K, Kandavelu P, Sankaran B, Kuramata M, Ishikawa S, Rosen BP, Yoshinaga M, Yoshinaga M.	Commun Biol	10.1038/s42003-019-0365-y	2019
Enzymology	2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes.	Brock M, Darley D, Textor S, Buckel W.	Eur J Biochem	10.1046/j.1432-1327.2001.02262.x	2001
Metabolism	The pipecolate-incorporating enzyme for the biosynthesis of the immunosuppressant rapamycin--nucleotide sequence analysis, disruption and heterologous expression of rapP from Streptomyces hygroscopicus.	Konig A, Schwecke T, Molnar I, Bohm GA, Lowden PA, Staunton J, Leadlay PF.	Eur J Biochem	10.1111/j.1432-1033.1997.00526.x	1997
	Genetic transformation and mutagenesis of the entomopathogenic fungus paecilomyces fumosoroseus	Cantone FA, Vandenberg JD.	J Invertebr Pathol	10.1006/jipa.1999.4885	1999
	The insect-protected CTC91087-6 sugarcane event expresses Cry1Ac protein preferentially in leaves and presents compositional equivalence to conventional sugarcane.	Gianotto AC, Rocha MS, Cutri L, Lopes FC, Dal'Acqua W, Hjelle JJ, Lirette RP, Oliveira WS, Sereno ML.	GM Crops Food	10.1080/21645698.2019.1651191	2019
Metabolism	Genome-wide miRNA expression profiling in potato (Solanum tuberosum L.) reveals TOR-dependent post-transcriptional gene regulatory networks in diverse metabolic pathway.	Deng K, Yin H, Xiong F, Feng L, Dong P, Ren M.	PeerJ	10.7717/peerj.10704	2021
Pathogenicity	[Resistance to its own antibiotic nigericin and macromolecular synthesis in Streptomyces hygroscopicus 155].	Ivanova IV, Khristova KR, Moncheva PA, Miteva VI.	Antibiot Khimioter		1995
Genetics	Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1.	Wang YD, Su YJ, Li JY, Yao XC, Liang GJ.	Int J Clin Exp Pathol		2015
Metabolism	Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis.	Cheng YR, Hauck L, Demain AL.	J Ind Microbiol	10.1007/bf01569962	1995
Pathogenicity	Specialized Metabolites Produced by Phytotopatogen Fungi to Control Weeds and Parasite Plants.	Evidente A.	Microorganisms	10.3390/microorganisms11040843	2023
Metabolism	Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus.	Kojima I, Cheng YR, Mohan V, Demain AL.	J Ind Microbiol	10.1007/bf01573954	1995
	The effects of sirolimus on target organs during mesenteric ischemia and reperfusion damage in an experimental rat model.	Sagiroglu T, Sezer A, Altaner S, Umit H, Yalta T, Yagci MA.	Curr Ther Res Clin Exp	10.1016/j.curtheres.2011.03.004	2011
Metabolism	Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus.	Fang A, Demain AL.	Folia Microbiol (Praha)	10.1007/bf02818516	1995
	Bioautography with TLC-MS/NMR for Rapid Discovery of Anti-tuberculosis Lead Compounds from Natural Sources.	Grzelak EM, Hwang C, Cai G, Nam JW, Choules MP, Gao W, Lankin DC, McAlpine JB, Mulugeta SG, Napolitano JG, Suh JW, Yang SH, Cheng J, Lee H, Kim JY, Cho SH, Pauli GF, Franzblau SG, Jaki BU.	ACS Infect Dis	10.1021/acsinfecdis.5b00150	2016
Metabolism	Sequence of a P-methyltransferase-encoding gene isolated from a bialaphos-producing Streptomyces hygroscopicus.	Hidaka T, Hidaka M, Kuzuyama T, Seto H.	Gene	10.1016/0378-1119(95)00101-b	1995
	The carboxyphosphonoenolpyruvate synthase-encoding gene from the bialaphos-producing organism Streptomyces hygroscopicus.	Lee SH, Hidaka T, Nakashita H, Seto H.	Gene	10.1016/0378-1119(94)00832-d	1995
	Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies.	Musa M, Zeppieri M, Atuanya GN, Enaholo ES, Topah EK, Ojo OM, Salati C.	Life (Basel)	10.3390/life13051120	2023
	Effect of Single and Combined Expression of Lysophosphatidic Acid Acyltransferase, Glycerol-3-Phosphate Acyltransferase, and Diacylglycerol Acyltransferase on Lipid Accumulation and Composition in Neochloris oleoabundans.	Munoz CF, Weusthuis RA, D'Adamo S, Wijffels RH.	Front Plant Sci	10.3389/fpls.2019.01573	2019
	Large-scale T-DNA mutagenesis in Arabidopsis for functional genomic analysis.	Galbiati M, Moreno MA, Nadzan G, Zourelidou M, Dellaporta SL.	Funct Integr Genomics	10.1007/s101420000007	2000
Biotechnology	Marine Actinomycetes, New Sources of Biotechnological Products.	Jagannathan SV, Manemann EM, Rowe SE, Callender MC, Soto W.	Mar Drugs	10.3390/md19070365	2021
Metabolism	Bioconversion of milbemycin-related compounds: biosynthetic pathway of milbemycins.	Nonaka K, Kumasaka C, Okamoto Y, Maruyama F, Yoshikawa H.	J Antibiot (Tokyo)	10.7164/antibiotics.52.109	1999
	Antibacterial potential of streptomycete strains from Antarctic soils.	Encheva-Malinova M, Stoyanova M, Avramova H, Pavlova Y, Gocheva B, Ivanova I, Moncheva P.	Biotechnol Biotechnol Equip	10.1080/13102818.2014.947066	2014
	Rapamycin, an mTOR inhibitor, induced apoptosis via independent mitochondrial and death receptor pathway in retinoblastoma Y79 cell.	Wang YD, Su YJ, Li JY, Yao XC, Liang GJ.	Int J Clin Exp Med		2015
Metabolism	Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase.	Shen Y, Sun F, Zhang L, Cheng Y, Zhu H, Wang SP, Jiao WH, Leadlay PF, Zhou Y, Lin HW.	J Biol Chem	10.1074/jbc.ra119.010922	2020
	New Antimicrobial Phenyl Alkenoic Acids Isolated from an Oil Palm Rhizosphere-Associated Actinomycete, Streptomyces palmae CMU-AB204^T.	Sujarit K, Mori M, Dobashi K, Shiomi K, Pathom-Aree W, Lumyong S.	Microorganisms	10.3390/microorganisms8030350	2020
Pathogenicity	Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus.	Cheng YR, Fang A, Demain AL.	Appl Microbiol Biotechnol	10.1007/bf00166931	1995
Metabolism	Milbemycin A4 oxime as a probe of azole transport in Candida glabrata.	Walker B, Izumikawa K, Tsai HF, Bennett JE.	FEMS Yeast Res	10.1111/1567-1364.12164	2014
	Protein-protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics.	Carro L.	Beilstein J Org Chem	10.3762/bjoc.14.267	2018
	Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.	Burnett GL, Yang YC, Aggen JB, Pitzen J, Gliedt MK, Semko CM, Marquez A, Evans JW, Wang G, Won WS, Tomlinson ACA, Kiss G, Tzitzilonis C, Thottumkara AP, Cregg J, Mellem KT, Choi JS, Lee JC, Zhao Y, Lee BJ, Meyerowitz JG, Knox JE, Jiang J, Wang Z, Wildes D, Wang Z, Singh M, Smith JAM, Gill AL.	J Med Chem	10.1021/acs.jmedchem.2c01658	2023
	Biolistic co-transformation of Metarhizium anisopliae var. acridum strain CG423 with green fluorescent protein and resistance to glufosinate ammonium.	Inglis PW, Aragao FJ, Frazao H, Magalhaes BP, Valadares-Inglis MC.	FEMS Microbiol Lett	10.1111/j.1574-6968.2000.tb09347.x	2000
	Transcription Factor Engineering for High-Throughput Strain Evolution and Organic Acid Bioproduction: A Review.	Li JW, Zhang XY, Wu H, Wu H, Bai YP.	Front Bioeng Biotechnol	10.3389/fbioe.2020.00098	2020
Metabolism	[Molecular-genetic study of the functional role of the regulatory gene brpB of the bialaphos producer Streptomyces hygroscopicus ATCC21705].	Tabakov VIu, Tokmakova IL, Voeikova TA.	Genetika		1994
Metabolism	Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects.	Granata S, Dalla Gassa A, Carraro A, Brunelli M, Stallone G, Lupo A, Zaza G.	Int J Mol Sci	10.3390/ijms17050735	2016
	Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma.	Ferrin G, Guerrero M, Amado V, Rodriguez-Peralvarez M, De la Mata M.	Int J Mol Sci	10.3390/ijms21041266	2020
	Immunosuppression in Glomerular Diseases: Implications for SARS-CoV-2 Vaccines and COVID-19.	Yeaman MR.	Glomerular Dis	10.1159/000519182	2021
	A 12-month single arm pilot study to evaluate the efficacy and safety of sirolimus in combination with tacrolimus in kidney transplant recipients at high immunologic risk.	Lee J, Lee JJ, Kim BS, Lee JG, Huh KH, Park Y, Kim YS.	J Korean Med Sci	10.3346/jkms.2015.30.6.682	2015
	The effects of lyophilization on the physico-chemical stability of sirolimus liposomes.	Ghanbarzadeh S, Valizadeh H, Zakeri-Milani P.	Adv Pharm Bull	10.5681/apb.2013.005	2013
Metabolism	Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.	Molnar I, Aparicio JF, Haydock SF, Khaw LE, Schwecke T, Konig A, Staunton J, Leadlay PF.	Gene	10.1016/0378-1119(95)00799-7	1996
	Structure of teichoic acid of the cell wall of Streptomyces sparsogenes VKM Ac-1744T.	Shashkov AS, Tul'skaya EM, Grachev AA, Evtushenko LI, Bueva OV, Naumova IB.	Biochemistry (Mosc)		1998
Metabolism	Allelopathic bacteria and their impact on higher plants.	Barazani O, Friedman J.	Crit Rev Microbiol	10.1080/20014091096693	2001
Metabolism	Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?	Nacarelli T, Azar A, Sell C.	Exp Gerontol	10.1016/j.exger.2014.11.004	2015
	Progress and trends in the development of therapies for Hutchinson-Gilford progeria syndrome.	Lai WF, Wong WT.	Aging Cell	10.1111/acel.13175	2020
	A signal-on fluorosensor based on quench-release principle for sensitive detection of antibiotic rapamycin.	Jeong HJ, Itayama S, Ueda H.	Biosensors (Basel)	10.3390/bios5020131	2015
	Local release of rapamycin by microparticles delays islet rejection within the anterior chamber of the eye.	Fan Y, Zheng X, Ali Y, Berggren PO, Loo SCJ.	Sci Rep	10.1038/s41598-019-40404-0	2019
Metabolism	Milbemycins alpha 11, alpha 12, alpha 13, alpha 14 and alpha 15: a new family of milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus. Taxonomy, fermentation, isolation, structure elucidation and biological properties.	Takahashi S, Miyaoka H, Tanaka K, Enokita R, Okazaki T.	J Antibiot (Tokyo)	10.7164/antibiotics.46.1364	1993
	Five-year follow-up after conversion from calcineurin inhibitor to sirolimus-based treatment in kidney transplant patients with chronic allograft nephropathy.	Xia SQ, Fan Y, Tan MY, Zheng JH.	Int J Clin Exp Med		2015
	Crosstalk between the mTOR pathway and primary cilia in human diseases.	Prosseda PP, Dannewitz Prosseda S, Tran M, Liton PB, Sun Y.	Curr Top Dev Biol	10.1016/bs.ctdb.2023.09.004	2023
	Secondary metabolite scale-up to minimize homolog impurity levels	Junker B, Reddy J, Olewinski R, Gailliot P, Byrne K, Gbewonyo K.	Biotechnol Bioeng	10.1002/(sici)1097-0290(19980905)59:5<595::aid-bit10>3.0.co;2-9	1998
Pathogenicity	Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro.	Namba DR, Ma G, Samad I, Ding D, Pandian V, Powell JD, Horton MR, Hillel AT.	Otolaryngol Head Neck Surg	10.1177/0194599815573708	2015
	Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. III. Structural elucidation.	Leet JE, Schroeder DR, Golik J, Matson JA, Doyle TW, Lam KS, Hill SE, Lee MS, Whitney JL, Krishnan BS.	J Antibiot (Tokyo)	10.7164/antibiotics.49.299	1996
	Sirolimus induced granulomatous interstitial pneumonitis.	Ussavarungsi K, Elsanjak A, Laski M, Raj R, Nugent K.	Respir Med Case Rep	10.1016/j.rmcr.2012.09.002	2012
	Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy.	Bouyahya A, El Allam A, Aboulaghras S, Bakrim S, El Menyiy N, Alshahrani MM, Al Awadh AA, Benali T, Lee LH, El Omari N, Goh KW, Ming LC, Mubarak MS.	Cancers (Basel)	10.3390/cancers14225520	2022
Metabolism	Use of soybean oil and ammonium sulfate additions to optimize secondary metabolite production.	Junker B, Mann Z, Gailliot P, Byrne K, Wilson J.	Biotechnol Bioeng	10.1002/(sici)1097-0290(19981205)60:5<580::aid-bit8>3.0.co;2-d	1998
	[Structure determination of new antifungal antibiotics, polaramycins A and B].	Meng W, Jin WZ.	Yao Xue Xue Bao		1997
Pathogenicity	Synergistic Inhibition of Tumor Necrosis Factor-Alpha-Stimulated Pro-Inflammatory Cytokine Expression in HaCaT Cells by a Combination of Rapamycin and Mycophenolic Acid.	Kim MY, Lim YY, Kim HM, Park YM, Kang H, Kim BJ.	Ann Dermatol	10.5021/ad.2015.27.1.32	2015
	Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination.	Rao Z, Chen X, Wu J, Xiao M, Zhang J, Wang B, Fang L, Zhang H, Wang X, Yang S, Chen Y.	Front Immunol	10.3389/fimmu.2019.02783	2019
Genetics	The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth.	Gonzalez S, Rallis C.	Front Cell Dev Biol	10.3389/fcell.2017.00061	2017
Pathogenicity	[Resistance of the strain Streptomyces hygroscopicus 155 to autogenous and other antibiotics].	Moncheva PA, Gancheva AG, Khristova KR, Ivanova IV.	Antibiot Khimioter		1992
Metabolism	Enhanced Triacylglycerol Metabolism Contributes to Efficient Oil Utilization and High-Level Production of Salinomycin in Streptomyces albus ZD11.	Li H, Wei J, Dong J, Li Y, Li Y, Chen Y, Guan W.	Appl Environ Microbiol	10.1128/aem.00763-20	2020
	Stomatitis And Everolimus: A Review Of Current Literature On 8,201 Patients.	Arena C, Troiano G, Zhurakivska K, Nocini R, Lo Muzio L.	Onco Targets Ther	10.2147/ott.s195121	2019
Metabolism	[Preparation and regeneration of protoplasts of the strain Streptomyces hygroscopicus 155].	Khristova KR, Petkova VT, Danilenko VN, Ivanova IV, Bakalov BV.	Antibiot Khimioter		1992
	Therapeutic monitoring of sirolimus in human whole-blood samples by high-performance liquid chromatography.	Maleki S, Graves S, Becker S, Horwatt R, Hicks D, Stroshane RM, Kincaid H.	Clin Ther	10.1016/s0149-2918(00)89020-7	2000
	Cytotoxic, larvicidal, nematicidal, and antifeedant activities of piperidin-connected 2-thioxoimidazolidin-4-one derivatives.	Arif IA, Ahamed A, Kumar RS, Idhayadhulla A, Manilal A.	Saudi J Biol Sci	10.1016/j.sjbs.2017.12.007	2019
Enzymology	A suicide inhibitor of nematode trehalose-6-phosphate phosphatases.	Cross M, York M, Dlugosz E, Straub JH, Biberacher S, Herath HMPD, Logan SA, Kim JS, Gasser RB, Ryan JH, Hofmann A.	Sci Rep	10.1038/s41598-019-52593-9	2019
	Concerted Flexibility of Chromatin Structure, Methylome, and Histone Modifications along with Plant Stress Responses.	Santos AP, Ferreira LJ, Oliveira MM.	Biology (Basel)	10.3390/biology6010003	2017
	Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds.	Caruso DJ, Palombo EA, Moulton SE, Zaferanloo B.	Microorganisms	10.3390/microorganisms10101990	2022
Pathogenicity	[Effect of protoplasting on antibiotic activity and resistance in the strain Streptomyces hygroscopicus 155].	Ivanova IV, Khristova KG, Tishkov SKh, Moncheva PA.	Antibiot Khimioter		1992
	When to consider liver transplantation in hepatocellular carcinoma patients?	Ma KW, Cheung TT.	Hepat Oncol	10.2217/hep-2016-0010	2017
	Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma.	Lu Z, Peng K, Wang N, Liu HM, Hou G.	J Immunol Res	10.1155/2016/7828916	2016
	Studies on the biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation: discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate	Nakashita H, Watanabe K, Hara O, Hidaka T, Seto H.	J Antibiot (Tokyo)	10.7164/antibiotics.50.212	1997
	Oncolytic Viruses in Combination Therapeutic Approaches with Epigenetic Modulators: Past, Present, and Future Perspectives.	Chianese A, Santella B, Ambrosino A, Stelitano D, Rinaldi L, Galdiero M, Zannella C, Franci G.	Cancers (Basel)	10.3390/cancers13112761	2021
	Rapamycin Influences the Efficiency of In vitro Fertilization and Development in the Mouse: A Role for Autophagic Activation.	Lee GK, Shin H, Lim HJ.	Asian-Australas J Anim Sci	10.5713/ajas.15.0762	2016
Metabolism	Studies on the biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation: discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate.	Nakashita H, Watanabe K, Hara O, Hidaka T, Seto H.	J Antibiot (Tokyo)		1997
	Tuberous sclerosis complex: review based on new diagnostic criteria.	Portocarrero LKL, Quental KN, Samorano LP, Oliveira ZNP, Rivitti-Machado MCDM.	An Bras Dermatol	10.1590/abd1806-4841.20186972	2018
	ABSCISIC ACID INSENSITIVE5 Interacts With RIBOSOMAL S6 KINASE2 to Mediate ABA Responses During Seedling Growth in Arabidopsis.	Li L, Zhu T, Song Y, Feng L, Farag EAH, Ren M.	Front Plant Sci	10.3389/fpls.2020.598654	2020
	Synthesis and biological evaluation of rapamycin-derived, next generation small molecules.	Guduru SKR, Arya P.	Medchemcomm	10.1039/c7md00474e	2018
Metabolism	Secondary metabolism in simulated microgravity.	Demain AL, Fang A.	Chem Rec	10.1002/tcr.1018	2001
	Sequencing of regions downstream of addA (98 degrees) and citG (289 degrees) in Bacillus subtilis.	Medina N, Vannier F, Roche B, Autret S, Levine A, Seror SJ.	Microbiology (Reading)	10.1099/00221287-143-10-3305	1997
	Target of rapamycin controls hyphal growth and pathogenicity through FoTIP4 in Fusarium oxysporum.	Li L, Zhu T, Song Y, Luo X, Datla R, Ren M.	Mol Plant Pathol	10.1111/mpp.13108	2021
Genetics	Genome Mining Coupled with OSMAC-Based Cultivation Reveal Differential Production of Surugamide A by the Marine Sponge Isolate Streptomyces sp. SM17 When Compared to Its Terrestrial Relative S. albidoflavus J1074.	Almeida EL, Kaur N, Jennings LK, Carrillo Rincon AF, Jackson SA, Thomas OP, Dobson ADW.	Microorganisms	10.3390/microorganisms7100394	2019
Metabolism	Cloning and analysis of DNA sequences from Streptomyces hygroscopicus encoding geldanamycin biosynthesis.	Allen IW, Ritchie DA.	Mol Gen Genet	10.1007/bf00284208	1994
	Assessment for the identification of better HDAC inhibitor class through binding energy calculations and descriptor analysis.	Subha K, Kumar GR.	Bioinformation	10.6026/97320630003218	2008
	Utilization of Phenol as Carbon Source by the Thermoacidophilic Archaeon Saccharolobus solfataricus P2 Is Limited by Oxygen Supply and the Cellular Stress Response.	Wolf J, Koblitz J, Albersmeier A, Kalinowski J, Siebers B, Schomburg D, Neumann-Schaal M.	Front Microbiol	10.3389/fmicb.2020.587032	2020
	Biocontrol of Aspergillus flavus on Peanut Kernels Using Streptomyces yanglinensis 3-10.	Shakeel Q, Lyu A, Zhang J, Wu M, Li G, Hsiang T, Yang L.	Front Microbiol	10.3389/fmicb.2018.01049	2018
	Biological Therapy with Complementary and Alternative Medicine in Innocuous Integrative Oncology: A Case of Cervical Cancer.	Chizenga EP, Abrahamse H.	Pharmaceutics	10.3390/pharmaceutics13050626	2021
	[Chromosomal determinant of Streptomyces hygroscopicus with positive influence on resistance to bialaphos controlled by the bar gene].	Tabakov VIu, Tokmakova IL, Sezonov GV.	Antibiot Khimioter		1992
Metabolism	Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase.	Aparicio JF, Molnar I, Schwecke T, Konig A, Haydock SF, Khaw LE, Staunton J, Leadlay PF.	Gene	10.1016/0378-1119(95)00800-4	1996
	17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma.	Singh S, Abu-Zaid A, Lin W, Low J, Abdolvahabi A, Jin H, Wu Q, Cooke B, Fang J, Bowling J, Vaithiyalingam S, Currier D, Yun MK, Fernando DM, Maier J, Tillman H, Bulsara P, Lu Z, Das S, Shelat A, Li Z, Young B, Lee R, Rankovic Z, Murphy AJ, White SW, Davidoff AM, Chen T, Yang J.	iScience	10.1016/j.isci.2020.101996	2021
Metabolism	Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines.	Guo W, Tan HY, Chen F, Wang N, Feng Y.	Cancers (Basel)	10.3390/cancers12020404	2020
	The Application of Ribosome Engineering to Natural Product Discovery and Yield Improvement in Streptomyces.	Zhu S, Duan Y, Huang Y.	Antibiotics (Basel)	10.3390/antibiotics8030133	2019
Metabolism	Phosphinothricin-tripeptide synthetases from Streptomyces viridochromogenes.	Grammel N, Schwartz D, Wohlleben W, Keller U.	Biochemistry	10.1021/bi9719410	1998
	Neuroprotective effect of rapamycin on spinal cord injury via activation of the Wnt/beta-catenin signaling pathway.	Gao K, Wang YS, Yuan YJ, Wan ZH, Yao TC, Li HH, Tang PF, Mei XF.	Neural Regen Res	10.4103/1673-5374.158360	2015
Enzymology	Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants.	Fabre A, Oleastro M, Nunes A, Santos A, Sifre E, Ducournau A, Benejat L, Buissonniere A, Floch P, Megraud F, Dubois V, Lehours P.	J Clin Microbiol	10.1128/jcm.00390-18	2018
Enzymology	Nucleotide sequence of a carboxyphosphonoenolpyruvate phosphonomutase gene isolated from a bialaphos-producing organism, Streptomyces hygroscopicus, and its expression in Streptomyces lividans.	Hidaka T, Hidaka M, Uozumi T, Seto H.	Mol Gen Genet	10.1007/bf00265446	1992
Metabolism	Inducing perylenequinone production from a bambusicolous fungus Shiraia sp. S9 through co-culture with a fruiting body-associated bacterium Pseudomonas fulva SB1.	Ma YJ, Zheng LP, Wang JW.	Microb Cell Fact	10.1186/s12934-019-1170-5	2019
Metabolism	Rapamycin Re-Directs Lysosome Network, Stimulates ER-Remodeling, Involving Membrane CD317 and Affecting Exocytosis, in Campylobacter Jejuni-Lysate-Infected U937 Cells.	Canonico B, Cesarini E, Montanari M, Di Sario G, Campana R, Galluzzi L, Sola F, Gundogdu O, Luchetti F, Diotallevi A, Baffone W, Giordano A, Papa S.	Int J Mol Sci	10.3390/ijms21062207	2020
Phylogeny	[Studies on the classification of thermophilic actinomycetes. IV. Determination of thermophilic Streptomyces hygroscopicus group].	Lu YY, Xu DY, Dai HP.	Wei Sheng Wu Xue Bao		1991
	TETX: a novel nuclear selection marker for Chlamydomonas reinhardtii transformation.	Garcia-Echauri SA, Cardineau GA.	Plant Methods	10.1186/s13007-015-0064-8	2015
Metabolism	MKAN27435 is required for the biosynthesis of higher subclasses of lipooligosaccharides in Mycobacterium kansasii.	Nataraj V, Pang PC, Haslam SM, Veerapen N, Minnikin DE, Dell A, Besra GS, Bhatt A.	PLoS One	10.1371/journal.pone.0122804	2015
Pathogenicity	Oligo-carrageenan kappa increases glucose, trehalose and TOR-P and subsequently stimulates the expression of genes involved in photosynthesis, and basal and secondary metabolisms in Eucalyptus globulus.	Saucedo S, Gonzalez A, Gomez M, Contreras RA, Laporte D, Saez CA, Zuniga G, Moenne A.	BMC Plant Biol	10.1186/s12870-019-1858-z	2019
Metabolism	Resistance to the polyether ionophore antibiotic pandavir (nigericin) in two producing strains of Streptomyces.	Moncheva PA, Christova KR, Ivanova IV.	J Antibiot (Tokyo)	10.7164/antibiotics.48.811	1995
Enzymology	Response Surface Methodology-Genetic Algorithm Based Medium Optimization, Purification, and Characterization of Cholesterol Oxidase from Streptomyces rimosus.	Srivastava A, Singh V, Haque S, Pandey S, Mishra M, Jawed A, Shukla PK, Singh PK, Tripathi CKM.	Sci Rep	10.1038/s41598-018-29241-9	2018
	Conversion of bialaphos to other oligopeptides containing phosphinothricin by Streptomyces hygroscopicus.	Kumada Y, Imai S, Nagaoka K.	J Antibiot (Tokyo)	10.7164/antibiotics.44.1006	1991
Metabolism	Chromatin-modifying drugs and metabolites in cell fate control.	Yao Z, Chen Y, Cao W, Shyh-Chang N.	Cell Prolif	10.1111/cpr.12898	2020
	Antibiotic Production and Antibiotic Resistance: The Two Sides of AbrB1/B2, a Two-Component System of Streptomyces coelicolor.	Sanchez de la Nieta R, Antoraz S, Alzate JF, Santamaria RI, Diaz M.	Front Microbiol	10.3389/fmicb.2020.587750	2020
	Epilepsy in the mTORopathies: opportunities for precision medicine.	Moloney PB, Cavalleri GL, Delanty N.	Brain Commun	10.1093/braincomms/fcab222	2021
	Activity of everolimus (RAD001) in relapsed and/or refractory multiple myeloma: a phase I study.	Gunther A, Baumann P, Burger R, Kellner C, Klapper W, Schmidmaier R, Gramatzki M.	Haematologica	10.3324/haematol.2014.116269	2015
	Cutting-Edge Delivery Systems and Adjuvants in Tolerogenic Vaccines: A Review.	Puricelli C, Boggio E, Gigliotti CL, Stoppa I, Sutti S, Rolla R, Dianzani U.	Pharmaceutics	10.3390/pharmaceutics14091782	2022
	Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis.	Klopries S, Sundermann U, Schulz F.	Beilstein J Org Chem	10.3762/bjoc.9.75	2013
	Rodent-targeted approaches to reduce acarological risk of human exposure to pathogen-infected Ixodes ticks.	Eisen L.	Ticks Tick Borne Dis	10.1016/j.ttbdis.2023.102119	2023
	Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester.	Castro-Falcon G, Seiler GS, Demir O, Rathinaswamy MK, Hamelin D, Hoffmann RM, Makowski SL, Letzel AC, Field SJ, Burke JE, Amaro RE, Hughes CC.	J Med Chem	10.1021/acs.jmedchem.8b00975	2018
Metabolism	An O-phosphotransferase catalyzes phosphorylation of hygromycin A in the antibiotic-producing organism Streptomyces hygroscopicus.	Dhote V, Gupta S, Reynolds KA.	Antimicrob Agents Chemother	10.1128/aac.00157-08	2008
Metabolism	Investigation of enzymatic C-P bond formation using multiple quantum HCP nuclear magnetic resonance spectroscopy.	Hu K, Werner WJ, Allen KD, Wang SC.	Magn Reson Chem	10.1002/mrc.4190	2015
Enzymology	Swit_4259, an acetoacetate decarboxylase-like enzyme from Sphingomonas wittichii RW1.	Mydy LS, Mashhadi Z, Knight TW, Fenske T, Hagemann T, Hoppe RW, Han L, Miller TR, Schwabacher AW, Silvaggi NR.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x17015862	2017
Enzymology	Studies on N-acetylglucosaminidase activity produced by Streptomyces hygroscopicus.	Irhuma A, Gallagher J, Hackett TJ, McHale AP.	Biochim Biophys Acta	10.1016/0304-4165(91)90029-g	1991
Pathogenicity	Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy.	Eiden AM, Zhang S, Gary JM, Simmons JK, Mock BA.	Clin Cancer Res	10.1158/1078-0432.ccr-14-3239	2016
Metabolism	Rapamycin attenuates endothelial apoptosis induced by low shear stress via mTOR and sestrin1 related redox regulation.	Zhang J, Wang Z, Zhang J, Zuo G, Li B, Mao W, Chen S.	Mediators Inflamm	10.1155/2014/769608	2014
	NADH-GOGAT Overexpression Does Not Improve Maize (Zea mays L.) Performance Even When Pyramiding with NAD-IDH, GDH and GS.	Canas RA, Yesbergenova-Cuny Z, Belanger L, Rouster J, Brule L, Gilard F, Quillere I, Sallaud C, Hirel B.	Plants (Basel)	10.3390/plants9020130	2020
	[Overcoming restriction of Streptomyces hygroscopicus 10-22 by the modification of S. fradiae--an attempt to develop a transformation system for S. hygroscopicus 10-22].	Qin Z, Deng Z, Zhou Q, Chen H.	Yi Chuan Xue Bao		1993
Metabolism	Investigation of the biosynthetic potential of endophytes in traditional Chinese anticancer herbs.	Miller KI, Qing C, Sze DM, Neilan BA.	PLoS One	10.1371/journal.pone.0035953	2012
Pathogenicity	IKKbeta is required for the formation of the NLRP3 inflammasome.	Nanda SK, Prescott AR, Figueras-Vadillo C, Cohen P.	EMBO Rep	10.15252/embr.202050743	2021
	The Competence of Maize Shoot Meristems for Integrative Transformation and Inherited Expression of Transgenes.	Zhong H, Sun B, Warkentin D, Zhang S, Wu R, Wu T, Sticklen MB.	Plant Physiol	10.1104/pp.110.4.1097	1996
Metabolism	Hydantocidin: a new compound with herbicidal activity from Streptomyces hygroscopicus.	Nakajima M, Itoi K, Takamatsu Y, Kinoshita T, Okazaki T, Kawakubo K, Shindo M, Honma T, Tohjigamori M, Haneishi T.	J Antibiot (Tokyo)	10.7164/antibiotics.44.293	1991
Metabolism	mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target.	Babicheva A, Makino A, Yuan JX.	Int J Mol Sci	10.3390/ijms22042144	2021
Metabolism	A mass spectrometry-guided genome mining approach for natural product peptidogenomics.	Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach MA, Moore BS, Dorrestein PC.	Nat Chem Biol	10.1038/nchembio.684	2011
Metabolism	The effects of TORC signal interference on lipogenesis in the oleaginous yeast Trichosporon oleaginosus.	Bracharz F, Redai V, Bach K, Qoura F, Bruck T.	BMC Biotechnol	10.1186/s12896-017-0348-3	2017
Metabolism	Morphology engineering of Streptomyces coelicolor M145 by sub-inhibitory concentrations of antibiotics.	Wang H, Zhao G, Ding X.	Sci Rep	10.1038/s41598-017-13493-y	2017
Metabolism	[Impact of nitrogen assimilation on regulation of antibiotic production in Streptomyces hygroscopicus 155].	Chipeva V, Dumanova E, Todorov Ts, Ivanova I.	Antibiot Khimioter		1991
Enzymology	Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. II. Isolation and characterization.	Leet JE, Schroeder DR, Krishnan BS, Matson JA.	J Antibiot (Tokyo)	10.7164/antibiotics.43.961	1990
	Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis.	Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, Bai L, Zhang H.	PLoS One	10.1371/journal.pone.0032033	2012
Enzymology	Isolation and characterization of a new 12-membered macrolide FD-895.	Seki-Asano M, Okazaki T, Yamagishi M, Sakai N, Takayama Y, Hanada K, Morimoto S, Takatsuki A, Mizoue K.	J Antibiot (Tokyo)	10.7164/antibiotics.47.1395	1994
	Development of a yeast heterologous expression cassette based on the promoter and terminator elements of the Eremothecium cymbalariae translational elongation factor 1alpha (EcTEF1) gene.	Linder T.	3 Biotech	10.1007/s13205-018-1224-0	2018
	mTOR inhibitors effects on regulatory T cells and on dendritic cells.	Stallone G, Infante B, Di Lorenzo A, Rascio F, Zaza G, Grandaliano G.	J Transl Med	10.1186/s12967-016-0916-7	2016
Pathogenicity	The integrative transformation of Pleurotus ostreatus using bialaphos resistance as a dominant selectable marker.	Yanai K, Yonekura K, Usami H, Hirayama M, Kajiwara S, Yamazaki T, Shishido K, Adachi T.	Biosci Biotechnol Biochem	10.1271/bbb.60.472	1996
	Major adverse limb events in patients with femoro-popliteal and below-the-knee peripheral arterial disease treated with either sirolimus-coated balloon or standard uncoated balloon angioplasty: a structured protocol summary of the "SirPAD" randomized controlled trial.	Barco S, Sebastian T, Voci D, Engelberger RP, Grigorean A, Holy E, Leeger C, Munger M, Periard D, Probst E, Spescha R, Held U, Kucher N.	Trials	10.1186/s13063-022-06242-8	2022
	Synthesis of the northern sector (C8-C19) of rapamycin via Chan rearrangement and oxidation of an alpha-acyloxyacetate.	White JD, Jeffrey SC.	Tetrahedron	10.1016/j.tet.2009.06.026	2009
Enzymology	Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.	Pollack SJ, Freeman S, Pompliano DL, Knowles JR.	Eur J Biochem	10.1111/j.1432-1033.1992.tb17342.x	1992
	An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes.	Aigle B, Schneider D, Morilhat C, Vandewiele D, Dary A, Holl AC, Simonet JM, Decaris B.	Microbiology (Reading)	10.1099/13500872-142-10-2815	1996
Pathogenicity	Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model.	Royster GD, Harris JC, Nelson A, Castro Y, Weitzel RP, Tisdale J, Heitmann RJ, DeCherney AH, Wolff EF.	Reprod Sci	10.1177/1933719119828110	2019
	Optimization of Fermentation Conditions and Media for Production of Glucose Isomerase from Bacillus megaterium Using Response Surface Methodology.	Thi Nguyen HY, Tran GB.	Scientifica (Cairo)	10.1155/2018/6842843	2018
Enzymology	Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells.	Jacquier M, Kuriakose S, Bhardwaj A, Zhang Y, Shrivastav A, Portet S, Varma Shrivastav S.	Sci Rep	10.1038/s41598-018-30447-0	2018
Metabolism	The Streptomyces leeuwenhoekii genome: de novo sequencing and assembly in single contigs of the chromosome, circular plasmid pSLE1 and linear plasmid pSLE2.	Gomez-Escribano JP, Castro JF, Razmilic V, Chandra G, Andrews B, Asenjo JA, Bibb MJ.	BMC Genomics	10.1186/s12864-015-1652-8	2015
	Nano-Antagonist Alleviates Inflammation and Allows for MRI of Atherosclerosis.	Mog B, Asase C, Chaplin A, Gao H, Rajagopalan S, Maiseyeu A.	Nanotheranostics	10.7150/ntno.37391	2019
	Optimization of medium compositions to improve a novel glycoprotein production by Streptomyces kanasenisi ZX01.	Zhou Y, Sun YB, He HW, Feng JT, Zhang X, Han LR.	AMB Express	10.1186/s13568-016-0316-7	2017
	Mechanical force-driven TNFalpha endocytosis governs stem cell homeostasis.	Yu W, Chen C, Kou X, Sui B, Yu T, Liu D, Wang R, Wang J, Shi S.	Bone Res	10.1038/s41413-020-00117-x	2021
Metabolism	Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. I. Taxonomy of producing organism, fermentation and biological activity.	Lam KS, Hesler GA, Mattei JM, Mamber SW, Forenza S, Tomita K.	J Antibiot (Tokyo)	10.7164/antibiotics.43.956	1990
Pathogenicity	Host-induced gene silencing of BcTOR in Botrytis cinerea enhances plant resistance to grey mould.	Xiong F, Liu M, Zhuo F, Yin H, Deng K, Feng S, Liu Y, Luo X, Feng L, Zhang S, Li Z, Ren M, Ren M.	Mol Plant Pathol	10.1111/mpp.12873	2019
	Aspergillus terreus Inhibits Growth and Induces Morphological Abnormalities in Pythium aphanidermatum and Suppresses Pythium-Induced Damping-Off of Cucumber.	Halo BA, Al-Yahyai RA, Al-Sadi AM.	Front Microbiol	10.3389/fmicb.2018.00095	2018
	A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var. beijingensis.	Shen J, Kong L, Li Y, Zheng X, Wang Q, Yang W, Deng Z, You D.	Synth Syst Biotechnol	10.1016/j.synbio.2018.12.004	2019
Metabolism	Global changes in gene expression related to antibiotic synthesis in Streptomyces hygroscopicus.	Holt TG, Chang C, Laurent-Winter C, Murakami T, Garrels JI, Davies JE, Thompson CJ.	Mol Microbiol	10.1111/j.1365-2958.1992.tb02163.x	1992
Pathogenicity	CP-60,993, a new dianemycin-like ionophore produced by Streptomyces hygroscopicus ATCC 39305: fermentation, isolation and characterization.	Cullen WP, Bordner J, Huang LH, Moshier PM, Oscarson JR, Presseau LA, Ware RS, Whipple EB, Kojima Y, Maeda H.	J Ind Microbiol	10.1007/bf01578095	1990
Metabolism	Protein tyrosine phosphorylation in streptomycetes.	Waters B, Vujaklija D, Gold MR, Davies J.	FEMS Microbiol Lett	10.1111/j.1574-6968.1994.tb07028.x	1994
	Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection.	Lo YC, Lee CF, Powell JD.	Curr Opin Organ Transplant	10.1097/mot.0000000000000098	2014
	An Update on Current Therapeutic Drugs Treating COVID-19.	Wu R, Wang L, Kuo HD, Shannar A, Peter R, Chou PJ, Li S, Hudlikar R, Liu X, Liu Z, Poiani GJ, Amorosa L, Brunetti L, Kong AN.	Curr Pharmacol Rep	10.1007/s40495-020-00216-7	2020
Metabolism	GdmRIII, a TetR Family Transcriptional Regulator, Controls Geldanamycin and Elaiophylin Biosynthesis in Streptomyces autolyticus CGMCC0516.	Jiang M, Yin M, Wu S, Han X, Ji K, Wen M, Lu T.	Sci Rep	10.1038/s41598-017-05073-x	2017
Genetics	Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms.	Alfatah M, Lim JJJ, Zhang Y, Naaz A, Cheng TYN, Yogasundaram S, Faidzinn NA, Lin JJ, Eisenhaber B, Eisenhaber F.	Elife	10.7554/elife.92178	2024
	A simple morphologically structured model describing the growth of filamentous microorganisms.	Nielsen J.	Biotechnol Bioeng	10.1002/bit.260410706	1993
Metabolism	Purification and characterization of citrate synthase from Streptomyces hygroscopicus SF-1293 and comparison of its properties with those of 2-phosphinomethylmalic acid synthase.	Shimotohno KW, Imai S, Murakami T, Seto H.	Agric Biol Chem	10.1080/00021369.1990.10869949	1990
Pathogenicity	Preconditioning of umbilical cord-derived mesenchymal stem cells by rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice via the CXCR4/CXCL12 axis.	Zheng J, Li H, He L, Huang Y, Cai J, Chen L, Zhou C, Fu H, Lu T, Zhang Y, Yao J, Yang Y.	Cell Prolif	10.1111/cpr.12546	2019
Metabolism	Long-term mTOR inhibitors administration evokes altered calcium homeostasis and platelet dysfunction in kidney transplant patients.	Lopez E, Berna-Erro A, Bermejo N, Brull JM, Martinez R, Garcia Pino G, Alvarado R, Salido GM, Rosado JA, Cubero JJ, Redondo PC.	J Cell Mol Med	10.1111/jcmm.12044	2013
Pathogenicity	Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus.	Wang C, Liu P, Luo J, Ding H, Gao Y, Sun L, Luo F, Liu X, He H.	Front Cell Infect Microbiol	10.3389/fcimb.2017.00267	2017
Pathogenicity	Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors.	Melick CH, Jewell JL.	Biochem J	10.1042/bcj20190958	2020
	Transcriptomic and Ultrastructural Analyses of Pyricularia Oryzae Treated With Fungicidal Peptaibol Analogs of Trichoderma Trichogin.	Sella L, Govind R, Caracciolo R, Quarantin A, Vu VV, Tundo S, Nguyen HM, Favaron F, Musetti R, De Zotti M.	Front Microbiol	10.3389/fmicb.2021.753202	2021
Metabolism	Production of novel rapamycin analogs by precursor-directed biosynthesis.	Ritacco FV, Graziani EI, Summers MY, Zabriskie TM, Yu K, Bernan VS, Carter GT, Greenstein M.	Appl Environ Microbiol	10.1128/aem.71.4.1971-1976.2005	2005
Enzymology	Enzymatic and molecular characterisation of leucine aminopeptidase of Burkholderia pseudomallei.	Liew SM, Tay ST, Puthucheary SD.	BMC Microbiol	10.1186/1471-2180-13-110	2013
Metabolism	Incorporation of acetate, propionate, and methionine into rapamycin by Streptomyces hygroscopicus.	Paiva NL, Demain AL, Roberts MF.	J Nat Prod	10.1021/np50073a015	1991
Metabolism	Mechanism of validamycin A inhibiting DON biosynthesis and synergizing with DMI fungicides against Fusarium graminearum.	Bian C, Duan Y, Xiu Q, Wang J, Tao X, Zhou M.	Mol Plant Pathol	10.1111/mpp.13060	2021
Metabolism	Molecular cloning and characterization of the gene conferring curromycin resistance on a curromycin non-producing mutant derived from Streptomyces hygroscopicus 358AV2.	Ogura M, Tanaka T, Seto H, Otake N.	J Antibiot (Tokyo)	10.7164/antibiotics.43.873	1990
Enzymology	Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro.	Leitmeyer K, Glutz A, Radojevic V, Setz C, Huerzeler N, Bumann H, Bodmer D, Brand Y.	Biomed Res Int	10.1155/2015/925890	2015
	An Ecotype of Neorickettsia risticii Causing Potomac Horse Fever in Canada.	Xiong Q, Bekebrede H, Sharma P, Arroyo LG, Baird JD, Rikihisa Y.	Appl Environ Microbiol	10.1128/aem.01366-16	2016
	Targeting mTOR in HIV-Negative Classic Kaposi's Sarcoma.	Merimsky O, Jiveliouk I, Sagi-Eisenberg R.	Sarcoma	10.1155/2008/825093	2008
	The Two Translationally Controlled Tumor Protein Genes, CsTCTP1 and CsTCTP2, Are Negative Modulators in the Cucumis sativus Defense Response to Sphaerotheca fuliginea.	Meng X, Yu Y, Zhao J, Cui N, Song T, Yang Y, Fan H.	Front Plant Sci	10.3389/fpls.2018.00544	2018
	Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens.	Vellanki S, Garcia AE, Lee SC.	Front Mol Biosci	10.3389/fmolb.2020.588913	2020
	A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program.	Stanfield B, Kaeberlein M, Leroux B, Jones J, Lucas R, Arroll B.	Trials	10.1186/s13063-024-08490-2	2024
	Formulation, characterization and evaluation of morusin loaded niosomes for potentiation of anticancer therapy.	Agarwal S, Mohamed MS, Raveendran S, Rochani AK, Maekawa T, Kumar DS.	RSC Adv	10.1039/c8ra06362a	2018
Pathogenicity	Tumor growth effects of rapamycin on human biliary tract cancer cells.	Heuer M, Dreger NM, Cicinnati VR, Fingas C, Juntermanns B, Paul A, Kaiser GM.	Eur J Med Res	10.1186/2047-783x-17-20	2012
Metabolism	Age-related macular degeneration (AMD) mitochondria modulate epigenetic mechanisms in retinal pigment epithelial cells.	Nashine S, Nesburn AB, Kuppermann BD, Kenney MC.	Exp Eye Res	10.1016/j.exer.2019.107701	2019
Metabolism	[Storage of Actinobacteria of the Genera Streptomyces and Nonomuraea by Low Temperature Preservation].	Sineva ON, Kulikova NG, Filippova SN, Terekhova LP	Antibiot Khimioter		2014
Pathogenicity	Lipoteichoic acid in Streptomyces hygroscopicus: structural model and immunomodulatory activities.	Cot M, Ray A, Gilleron M, Vercellone A, Larrouy-Maumus G, Armau E, Gauthier S, Tiraby G, Puzo G, Nigou J	PLoS One	10.1371/journal.pone.0026316	2011
	An actinomycete isolate from solitary wasp mud nest having strong antibacterial activity and kills the Candida cells due to the shrinkage and the cytosolic loss.	Kumar V, Naik B, Gusain O, Bisht GS	Front Microbiol	10.3389/fmicb.2014.00446	2014
Metabolism	Enzymatic synthesis of aminoglycoside antibiotics: novel adenosylmethionine:2-deoxystreptamine N-methyltransferase activities in hygromycin B- and spectinomycin-producing Streptomyces spp. and uses of the methylated products.	Walker JB	Appl Environ Microbiol	10.1128/AEM.68.5.2404-2410.2002	2002
Metabolism	Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin.	Garrity GM, Heimbuch BK, Motamedi H, Shafiee A	J Ind Microbiol	10.1007/BF01570127	1993
Phylogeny	Cadeguomycin, a noval nucleoside analog antibiotic. I. The producing organism, production and isolation of cadeguomycin.	Tanaka N, Wu RT, Okabe T, Yamashita H, Shimazu A, Nishimura T	J Antibiot (Tokyo)	10.7164/antibiotics.35.272	1982
Phylogeny	Description of Streptomyces explomaris sp. nov., isolated from the coastal soil rhizosphere of Juniperus excelsa and reclassification of Streptomyces libani as a later heterotypic synonym of Streptomyces nigrescens.	Shu W, Ruckert-Reed C, Gromyko O, Tistechok S, Kalinowski J, Luzhetskyy A, Wittmann C.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006711	2025
Phylogeny	Reclassification of four subspecies in the genus Streptomyces to Streptomyces rubradiris sp. nov., Streptomyces asoensis sp. nov., Streptomyces fructofermentans sp. nov. and Streptomyces ossamyceticus sp. nov.	Komaki H, Tamura T.	Int J Syst Evol Microbiol	10.1099/ijsem.0.005078	2021
	A novel endophytic species, Streptomyces colwelliae sp. nov., isolated from root nodule of Alnus glutinosa.	Nouioui I, Gomez-Escribano JP, Potter G, Jando M, Wolf J, Neumann-Schaal M, Mast Y.	BMC Microbiol	10.1186/s12866-025-04290-z	2025
Genetics	Streptomyces huangiella sp. nov., an endophytic actinomycete isolated from Pheretima aspergillum, a promising candidate for biological pathogen control.	Huang D, Tan J, Liao J, Zhu L, Zhang X, Feng D, Liu W, Jin X.	Microbiol Spectr	10.1128/spectrum.00717-25	2025
Phylogeny	Streptomyces capitiformicae sp. nov., a novel actinomycete producing angucyclinone antibiotics isolated from the head of Camponotus japonicus Mayr.	Jiang S, Piao C, Yu Y, Cao P, Li C, Yang F, Li M, Xiang W, Liu C.	Int J Syst Evol Microbiol	10.1099/ijsem.0.002468	2018
	Streptomyces rugosispiralis sp. nov., a Novel Actinobacterium Isolated from Peat Swamp Forest Soil That Produces Ansamycin Derivatives and Nocardamines.	Weeraphan T, Supong K, Sripreechasak P, Jutakanoke R, Kowinthanaphat S, Tanasupawat S, Pittayakhajonwut P, Phongsopitanun W.	Antibiotics (Basel)	10.3390/antibiotics12091467	2023
Phylogeny	Reclassification of Streptomyces hygroscopicus strains as Streptomyces aldersoniae sp. nov., Streptomyces angustmyceticus sp. nov., comb. nov., Streptomyces ascomycinicus sp. nov., Streptomyces decoyicus sp. nov., comb. nov., Streptomyces milbemycinicus sp. nov. and Streptomyces wellingtoniae sp. nov.	Kumar Y, Goodfellow M.	Int J Syst Evol Microbiol	10.1099/ijs.0.012161-0	2010
Phylogeny	Five new members of the Streptomyces violaceusniger 16S rRNA gene clade: Streptomyces castelarensis sp. nov., comb. nov., Streptomyces himastatinicus sp. nov., Streptomyces mordarskii sp. nov., Streptomyces rapamycinicus sp. nov. and Streptomyces ruanii sp. nov.	Kumar Y, Goodfellow M.	Int J Syst Evol Microbiol	10.1099/ijs.0.65408-0	2008
Phylogeny	Streptomyces iranensis sp. nov., isolated from soil.	Hamedi J, Mohammadipanah F, Klenk HP, Potter G, Schumann P, Sproer C, von Jan M, Kroppenstedt RM.	Int J Syst Evol Microbiol	10.1099/ijs.0.015339-0	2010
Genetics	Genome insights into the pharmaceutical and plant growth promoting features of the novel species Nocardia alni sp. nov.	Nouioui I, Ha SM, Baek I, Chun J, Goodfellow M.	BMC Genomics	10.1186/s12864-021-08257-y	2022
Genetics	Genome-based classification of the Streptomyces violaceusniger clade and description of Streptomyces sabulosicollis sp. nov. from an Indonesian sand dune.	Kusuma AB, Nouioui I, Goodfellow M.	Antonie Van Leeuwenhoek	10.1007/s10482-021-01564-0	2021
Metabolism	Streptomyces cameroonensis sp. nov., a Geldanamycin Producer That Promotes Theobroma cacao Growth.	Boudjeko T, Tchinda RA, Zitouni M, Nana JA, Lerat S, Beaulieu C.	Microbes Environ	10.1264/jsme2.me16095	2017

References

#9659	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40578
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#25185	H. I. Komaki, N.,Oguchi, A.,Hamada, M.,Tamura, T.,Fujita, N.,Suzuki, K. I.: Genome analysis-based reclassification of Streptomyces endus and Streptomyces sporocinereus as later heterotypic synonyms of Streptomyces hygroscopicus subsp. hygroscopicus. IJSEM 67: 343 - 345 2017 ( DOI 10.1099/ijsem.0.001628 , PubMed 27902297 )
#35999	; Curators of the CIP;
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120019	Collection of Institut Pasteur ; Curators of the CIP; CIP 106840
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptomyces hygroscopicus subsp. hygroscopicus (DSM 40578, ATCC 27438, CBS 773.72)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Pigmentation

Multimedia

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Compound production

Halophily

Metabolite utilization

Antibiotic resistance

Metabolite production

Metabolite tests

Enzymes

API biotype100

Isolation, sampling and environmental information

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_001553455

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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