Actinomyces naeslundii (DSM 17233, ATCC 19039, CCUG 35337)

Name: Actinomyces naeslundii (DSM 17233, ATCC 19039, CCUG 35337)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 153

Type strain

Strain Designation Bowden X600S-96, CS 1752, X-600

Culture col. no. DSM 17233 ATCC 19039 CCUG 35337 DSM 43325 WVU 447 8 more

NCBI tax ID(s) 1655

Special Collections DSMZ CCUG JCM CIP

History DSMZ <- CCUG; <- G. Bowden; <- M. A. Gerencser; WVU 447 <- L. K. Georg; CDC X-600 <- A. Howell; CS 1752 JCM <-- N. Maeda TPR-9 <-- ATCC 19039 <-- L. Georg CDC X-600 <-- A. Howell CS1752. CIP <- 1982, ATCC <- L. Georg, CDC: strain X-600 <- A. Howell: strain CS 1752

Links

Actinomyces naeslundii Bowden X600S-96 is a microaerophile, Gram-positive, rod-shaped human pathogen that was isolated from human dental plaque.

Gram-positive rod-shaped microaerophile human pathogen 16S sequence Bacteria

Name and taxonomic classification

SI-ID 36817

ATCC 19039,CCUG 35337,DSM 43325,CIP 100654,CIP 104837,JCM 8350,CIP 82.9,DSM 17233

@ref 20215

Last LPSN update 2026-05-29 08:24:57

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Actinomycetales

Family Actinomycetaceae

Genus Actinomyces

Species Actinomyces naeslundii

Full scientific name Actinomyces naeslundii corrig. Thompson and Lovestedt 1951 (Approved Lists 1980)

Synonyms (1)

Actinomyces naeslundi

BacDive ID	Other strains from **Actinomyces naeslundii** (80)	Type strain
154	A. naeslundii DSM 43013, ATCC 12104, CCUG 2238, NCTC 10301, ... (type strain)
136024	A. naeslundii 729-85, CIP 101863
136035	A. naeslundii 981-85, CIP 102031
136096	A. naeslundii 473-86, CIP 102471
137742	A. naeslundii 223-83, CIP 100149
137754	A. naeslundii 982-83, CIP 100594
137852	A. naeslundii 727-85, CIP 101864
138018	A. naeslundii 403-82, CIP 102481
138635	A. naeslundii 480-85, CIP 101693
139080	A. naeslundii 716-84, CIP 101115
143351	A. naeslundii CCUG 18701
144956	A. naeslundii CCUG 27287
146052	A. naeslundii CCUG 30267
147102	A. naeslundii CCUG 32866
147393	A. naeslundii CCUG 33517
147395	A. naeslundii CCUG 33519
147397	A. naeslundii CCUG 33521
147398	A. naeslundii CCUG 33522
147399	A. naeslundii CCUG 33523
147447	A. naeslundii CCUG 33596
147448	A. naeslundii CCUG 33597
147621	A. naeslundii CCUG 33912
147622	A. naeslundii CCUG 33913
147623	A. naeslundii CCUG 33914
147628	A. naeslundii CCUG 33919
147637	A. naeslundii CCUG 33928
147638	A. naeslundii CCUG 33929
147663	A. naeslundii CCUG 33970
147665	A. naeslundii CCUG 33972
147678	A. naeslundii CCUG 33995
147687	A. naeslundii CCUG 34004
147691	A. naeslundii CCUG 34008
147761	A. naeslundii CCUG 34187
147762	A. naeslundii CCUG 34188
147763	A. naeslundii CCUG 34189
147764	A. naeslundii CCUG 34190
147765	A. naeslundii CCUG 34191
147766	A. naeslundii CCUG 34193
147778	A. naeslundii CCUG 34212
148045	A. naeslundii CCUG 34725
148046	A. naeslundii CCUG 34726
148047	A. naeslundii CCUG 34727
148048	A. naeslundii CCUG 34728
148087	A. naeslundii CCUG 34801
148088	A. naeslundii CCUG 34802
148089	A. naeslundii CCUG 34803
148090	A. naeslundii CCUG 34804
148091	A. naeslundii CCUG 34805
148092	A. naeslundii CCUG 34806
148094	A. naeslundii CCUG 34808
148096	A. naeslundii CCUG 34810
148098	A. naeslundii CCUG 34812
148099	A. naeslundii CCUG 34813
148100	A. naeslundii CCUG 34814
148101	A. naeslundii CCUG 34815
148102	A. naeslundii CCUG 34816
148106	A. naeslundii CCUG 34820
148107	A. naeslundii CCUG 34821
148117	A. naeslundii CCUG 34838
148387	A. naeslundii CCUG 35334
148430	A. naeslundii CCUG 35425
148814	A. naeslundii CCUG 35999
149367	A. naeslundii CCUG 37599
150536	A. naeslundii CCUG 41524
150657	A. naeslundii CCUG 41882
151234	A. naeslundii CCUG 43520 A
151237	A. naeslundii CCUG 43520 D
152609	A. naeslundii CCUG 47191
152642	A. naeslundii CCUG 47269
153158	A. naeslundii CCUG 48600
153535	A. naeslundii CCUG 50100
153994	A. naeslundii CCUG 51873
153997	A. naeslundii CCUG 51890
154739	A. naeslundii CCUG 55048
155214	A. naeslundii CCUG 56934 B
155289	A. naeslundii CCUG 57217
155904	A. naeslundii CCUG 59618
156424	A. naeslundii CCUG 61684
156697	A. naeslundii CCUG 64199
156892	A. naeslundii CCUG 66423

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
121220	positive	rod-shaped

Colony morphology

121220

Hemolysis ability1

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
6829	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
37076	MEDIUM 6 - Columbia agar with 10 % horse blood		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
121220	CIP Medium 6	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
6829	positive	growth	37
37076	positive	growth	37
67770	positive	growth	37
121220	positive	growth	25-41
121220	negative	growth	10
121220	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
6829	microaerophile
121220	facultative anaerobe

Halophily

@ref	Salt	Growth	Tested relation	Concentration
121220	NaCl	positive	growth	0-2 %
121220	NaCl		growth	4 %
121220	NaCl		growth	6 %
121220	NaCl		growth	8 %
121220	NaCl		growth	10 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68381	40585 ChEBI	alpha-cyclodextrin	-	builds acid from	from API rID32STR
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	+	builds acid from	from API 50CH acid
68381	29016 ChEBI	arginine	-	hydrolysis	from API rID32STR
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
121220	16947 ChEBI	citrate	-	carbon source
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68381	18333 ChEBI	D-arabitol	-	builds acid from	from API rID32STR
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68379	17634 ChEBI	D-glucose	+	fermentation	from API Coryne
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68379	16899 ChEBI	D-mannitol	-	fermentation	from API Coryne
68381	16899 ChEBI	D-mannitol	-	builds acid from	from API rID32STR
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68380	16024 ChEBI	D-mannose	+	fermentation	from API rID32A
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68381	16988 ChEBI	D-ribose	-	builds acid from	from API rID32STR
68371	17924 ChEBI	D-sorbitol	+	builds acid from	from API 50CH acid
68381	16443 ChEBI	D-tagatose	-	builds acid from	from API rID32STR
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68379	65327 ChEBI	D-xylose	-	fermentation	from API Coryne
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68379	4853 ChEBI	esculin	+	hydrolysis	from API Coryne
121220	4853 ChEBI	esculin	+	hydrolysis
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68379	5291 ChEBI	gelatin	-	hydrolysis	from API Coryne
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	+	builds acid from	from API 50CH acid
68379	28087 ChEBI	glycogen	-	fermentation	from API Coryne
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68381	28087 ChEBI	glycogen	-	builds acid from	from API rID32STR
68381	606565 ChEBI	hippurate	-	hydrolysis	from API rID32STR
121220	606565 ChEBI	hippurate	-	hydrolysis
68381	30849 ChEBI	L-arabinose	-	builds acid from	from API rID32STR
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68379	17716 ChEBI	lactose	-	fermentation	from API Coryne
68381	17716 ChEBI	lactose	-	builds acid from	from API rID32STR
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68379	17306 ChEBI	maltose	+	fermentation	from API Coryne
68381	17306 ChEBI	maltose	+	builds acid from	from API rID32STR
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68381	6731 ChEBI	melezitose	-	builds acid from	from API rID32STR
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	+	builds acid from	from API 50CH acid
68381	28053 ChEBI	melibiose	+	builds acid from	from API rID32STR
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68381	320055 ChEBI	methyl beta-D-glucopyranoside	-	builds acid from	from API rID32STR
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	+	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	+	builds acid from	from API 50CH acid
68379	17632 ChEBI	nitrate	+	reduction	from API Coryne
68380	17632 ChEBI	nitrate	+	reduction	from API rID32A
121220	17632 ChEBI	nitrate	+	reduction
121220	17632 ChEBI	nitrate	+	respiration
121220	16301 ChEBI	nitrite	-	reduction
68371	0 ChEBI	Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371	0 ChEBI	Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68381	27941 ChEBI	pullulan	-	builds acid from	from API rID32STR
68381	16634 ChEBI	raffinose	+	builds acid from	from API rID32STR
68380	16634 ChEBI	raffinose	+	fermentation	from API rID32A
68371	16634 ChEBI	raffinose	+	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	+	builds acid from	from API 50CH acid
68381	30911 ChEBI	sorbitol	-	builds acid from	from API rID32STR
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68379	17992 ChEBI	sucrose	+	fermentation	from API Coryne
68381	17992 ChEBI	sucrose	+	builds acid from	from API rID32STR
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68381	27082 ChEBI	trehalose	+	builds acid from	from API rID32STR
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68379	16199 ChEBI	urea	-	hydrolysis	from API Coryne
68381	16199 ChEBI	urea	-	hydrolysis	from API rID32STR
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Antibiotic resistance

@ref	Metabolite	Is sensitive	Is resistant
121220	0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)

Metabolite production

@ref	Chebi-ID	Metabolite
68381	15688 ChEBI	acetoin	from API rID32STR
68380	35581 ChEBI	indole	from API rID32A
121220	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test	Indole test
68381	15688 ChEBI	acetoin	-			from API rID32STR
121220	15688 ChEBI	acetoin	-
121220	17234 ChEBI	glucose		+
68380	35581 ChEBI	indole			-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68380	alanine arylamidase	-	3.4.11.2	from API rID32A
68381	Alanyl-Phenylalanyl-Proline arylamidase	-		from API rID32STR
121220	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68381	alkaline phosphatase	-	3.1.3.1	from API rID32STR
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68382	alpha-galactosidase	+	3.2.1.22	from API zym
68381	alpha-galactosidase	+	3.2.1.22	from API rID32STR
68380	alpha-galactosidase	+	3.2.1.22	from API rID32A
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68380	alpha-glucosidase	+	3.2.1.20	from API rID32A
68382	alpha-mannosidase	-	3.2.1.24	from API zym
121220	amylase	+
68381	arginine dihydrolase	-	3.5.3.6	from API rID32STR
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68382	beta-galactosidase	+	3.2.1.23	from API zym
121220	beta-galactosidase	+	3.2.1.23
68380	beta-galactosidase	+	3.2.1.23	from API rID32A
68381	beta-galactosidase	+	3.2.1.23	from API rID32STR
68379	beta-galactosidase	+	3.2.1.23	from API Coryne
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68382	beta-glucosidase	+	3.2.1.21	from API zym
68381	beta-glucosidase	+	3.2.1.21	from API rID32STR
68380	beta-glucosidase	+	3.2.1.21	from API rID32A
68379	beta-glucosidase	+	3.2.1.21	from API Coryne
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
68381	beta-glucuronidase	-	3.2.1.31	from API rID32STR
68379	beta-glucuronidase	-	3.2.1.31	from API Coryne
68381	beta-mannosidase	-	3.2.1.25	from API rID32STR
121220	caseinase	-	3.4.21.50
121220	catalase	-	1.11.1.6
68379	catalase	-	1.11.1.6	from API Coryne
68382	cystine arylamidase	-	3.4.11.3	from API zym
121220	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	-		from API zym
121220	gamma-glutamyltransferase	-	2.3.2.2
121220	gelatinase	-
68379	gelatinase	-		from API Coryne
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	glycin arylamidase	-		from API rID32A
68381	glycyl tryptophan arylamidase	-		from API rID32STR
68380	histidine arylamidase	-		from API rID32A
68380	L-arginine arylamidase	-		from API rID32A
121220	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
68380	leucine arylamidase	+	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
121220	lipase	-
68382	lipase (C 14)	-		from API zym
121220	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68381	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32STR
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68379	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API Coryne
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
121220	ornithine decarboxylase	-	4.1.1.17
121220	oxidase	-
121220	phenylalanine ammonia-lyase	-	4.3.1.24
68380	phenylalanine arylamidase	+		from API rID32A
68380	proline-arylamidase	+	3.4.11.5	from API rID32A
121220	protease	-
68379	pyrazinamidase	+	3.5.1.B15	from API Coryne
68381	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32STR
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68379	pyrrolidonyl arylamidase	-	3.4.19.3	from API Coryne
68380	serine arylamidase	-		from API rID32A
68382	trypsin	-	3.4.21.4	from API zym
121220	tryptophan deaminase	-
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
121220	tween esterase	-
68380	tyrosine arylamidase	+		from API rID32A
121220	urease	+	3.5.1.5
68380	urease	-	3.5.1.5	from API rID32A
68379	urease	-	3.5.1.5	from API Coryne
68381	urease	-	3.5.1.5	from API rID32STR
68382	valine arylamidase	+		from API zym

API coryne

@ref	Reduction of nitrateNIT	PYZ	PYRA	PAL	beta GUR	beta GAL	alpha GLU	beta NAG	ESC	URE	GEL	Control fermentationControl	GLU	RIB	XYL	MAN	MAL	LAC	SAC	GLYG	CAT
6829	+	+	-	-	-	+	-	-	+	-	-	-	+	+/-	-	-	+	-	+	-	-
52676	+	+	-	+	-	+	+	-	+	-	-	-	+	+	-	-	+	-	+	-	-

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
121220	-	-	+	-	-	+	+	-	-	-	+	+	+	+	-	+	+	-	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
121220	not determinedn.d.	+	-	-	-	+/-	-	-	-	-	+	+	+	+	-	-	-	+	-	+	-	-	+	-	+	+	+	+/-	+	-	+	+	+/-	+/-	-	+	-	-	-	-	+/-	-	-	-	-	-	-	+/-	-	-

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
6829	-	-	+	+	-	+	+	-	-	-	+	+	-	-	+	-	-	-	+	-	+	+	-	+	-	-	-	-	-

API rID32STR

@ref	ADH (Arg)	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	TAG	beta MAN	URE
52676	-	+	-	-	+	-	-	-	-	-	+	+	+	-	-	-	-	-	+	-	-	-	-	-	-	+	+	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body-Site	#Oral cavity and airways	#Plaque

Isolation

@ref	Sample type	Host species	Country	Country ISO 3 Code	Continent
6829	human dental plaque	Homo sapiens	USA	USA	North America
52676	Human dental plaque [6551]	Homo sapiens
67770	Plaque from human tooth	Homo sapiens
121220	Human, Dental plaque	Homo sapiens

Taxonmaps

69479

Global distribution of 16S sequence LC037216 (>99% sequence identity) for Actinomyces naeslundii subclade from Microbeatlas

Aquatic Samples	595
Soil Samples	345
Animal Samples	22069
Plant Samples	125
Total Samples	23134

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Pathogenicity animal	Biosafety level	Biosafety level comment
6829			2	Risk group (German classification) According to TRBA 466
121220			2	Risk group (French classification) According to TRBA 466

Sequence information

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
67770	Actinomyces naeslundii gene for 16S ribosomal RNA, partial sequence, strain: JCM 8350	LC037216	1522		1655

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Co-culture of Helicobacter pylori with oral microorganisms in human saliva.	Scholz KJ, Hohne A, Wittmer A, Hacker G, Hellwig E, Cieplik F, Waidner B, Al-Ahmad A.	Clin Oral Investig	10.1007/s00784-025-06160-4	2025
	Antibacterial potential of silver and zinc loaded plasma-electrolytic oxidation coatings for dental titanium implants.	Paiwand S, Schafer S, Kopp A, Beikler T, Fiedler I, Gosau M, Fuest S, Smeets R.	Int J Implant Dent	10.1186/s40729-025-00595-w	2025
	Nitrate and a nitrate-reducing Rothia aeria strain as potential prebiotic or synbiotic treatments for periodontitis.	Mazurel D, Carda-Dieguez M, Langenburg T, Ziemyte M, Johnston W, Martinez CP, Albalat F, Llena C, Al-Hebshi N, Culshaw S, Mira A, Rosier BT.	NPJ Biofilms Microbiomes	10.1038/s41522-023-00406-3	2023
	Marginal Adaptation and Microbial Leakage at Conometric Prosthetic Connections for Implant-Supported Single Crowns: An In Vitro Investigation.	Gehrke P, Hartjen P, Smeets R, Gosau M, Peters U, Beikler T, Fischer C, Stolzer C, Geis-Gerstorfer J, Weigl P, Schafer S.	Int J Mol Sci	10.3390/ijms22020881	2021
	Bacterial Adhesion of TESPSA and Citric Acid on Different Titanium Surfaces Substrate Roughness: An In Vitro Study with a Multispecies Oral Biofilm Model.	Vilarrasa J, Alvarez G, Soler-Olle A, Gil J, Nart J, Blanc V.	Materials (Basel)	10.3390/ma16134592	2023
	Surface properties and initial bacterial biofilm growth on 3D-printed oral appliances: a comparative in vitro study.	Wuersching SN, Westphal D, Stawarczyk B, Edelhoff D, Kollmuss M.	Clin Oral Investig	10.1007/s00784-022-04838-7	2023
	Erythritol-enriched powder and oral biofilm regrowth on dental implants: an in vitro study.	Amate-Fernandez P, Figueiredo R, Blanc V, Alvarez G, Leon R, Valmaseda-Castellon E.	Med Oral Patol Oral Cir Bucal	10.4317/medoral.24622	2021
	Rapid identification of oral Actinomyces species cultivated from subgingival biofilm by MALDI-TOF-MS.	Stingu CS, Borgmann T, Rodloff AC, Vielkind P, Jentsch H, Schellenberger W, Eschrich K.	J Oral Microbiol	10.3402/jom.v7.26110	2015
Enzymology	In Vitro Effect of Porphyromonas gingivalis Methionine Gamma Lyase on Biofilm Composition and Oral Inflammatory Response.	Stephen AS, Millhouse E, Sherry L, Aduse-Opoku J, Culshaw S, Ramage G, Bradshaw DJ, Burnett GR, Allaker RP.	PLoS One	10.1371/journal.pone.0169157	2016
Phenotype	Biofilm viability checker: An open-source tool for automated biofilm viability analysis from confocal microscopy images.	Mountcastle SE, Vyas N, Villapun VM, Cox SC, Jabbari S, Sammons RL, Shelton RM, Walmsley AD, Kuehne SA.	NPJ Biofilms Microbiomes	10.1038/s41522-021-00214-7	2021
	Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells.	Brown JL, Johnston W, Delaney C, Rajendran R, Butcher J, Khan S, Bradshaw D, Ramage G, Culshaw S.	Sci Rep	10.1038/s41598-019-52115-7	2019
	The antibacterial and antibiofilm role of cannabidiol against periodontopathogenic bacteria.	Santos ALO, Santiago MB, Silva NBS, Souza SL, Almeida JMD, Martins CHG.	J Appl Microbiol	10.1093/jambio/lxae316	2025
	Potential in vitro anti-periodontopathogenic, anti-Chikungunya activities and in vivo toxicity of Brazilian red propolis.	Silva NBS, de Souza JH, Santiago MB, da Silva Aguiar JR, Martins DOS, da Silva RA, de Andrade Santos I, Aldana-Mejia JA, Jardim ACG, Dos Santos Pedroso R, Ambrosio SR, Veneziani RCS, Bastos JK, Pires RH, Martins CHG.	Sci Rep	10.1038/s41598-022-24776-4	2022
	Antibacterial Effect of Combined Electrolytic and Chemical Decontamination Methods on Dental Implant Surfaces: In Vitro Study.	Odeh V, Virto L, Garcia-Quismondo E, Herrera D, Palma J, Sanz M.	Clin Oral Implants Res	10.1111/clr.70012	2025
	The Impact of Candida albicans in the Development, Kinetics, Structure, and Cell Viability of Biofilms on Implant Surfaces-An In Vitro Study with a Validated Multispecies Biofilm Model.	Bravo E, Arce M, Ribeiro-Vidal H, Herrera D, Sanz M.	Int J Mol Sci	10.3390/ijms25063277	2024
	The Effect of Xanthohumol and Thymol on Candida albicans Filamentation and Its Impact on the Structure, Size, and Cell Viability of Biofilms Developed over Implant Surfaces.	Bravo E, Arce M, Herrera D, Sanz M.	Cells	10.3390/cells13221877	2024
	The Antimicrobial Activity of Curcumin and Xanthohumol on Bacterial Biofilms Developed over Dental Implant Surfaces.	Alonso-Espanol A, Bravo E, Ribeiro-Vidal H, Virto L, Herrera D, Alonso B, Sanz M.	Int J Mol Sci	10.3390/ijms24032335	2023
	Antibacterial Effect of Functionalized Polymeric Nanoparticles on Titanium Surfaces Using an In Vitro Subgingival Biofilm Model.	Bueno J, Virto L, Toledano-Osorio M, Figuero E, Toledano M, Medina-Castillo AL, Osorio R, Sanz M, Herrera D.	Polymers (Basel)	10.3390/polym14030358	2022
	Identification of Substances Produced by Cercospora brachiata in Absence of Light and Evaluation of Antibacterial Activity.	Felisbino JKRP, Vieira BS, de Oliveira A, da Silva NA, Martins CHG, Santiago MB, Munoz RAA, Cunha LCS, Sousa RMF.	J Fungi (Basel)	10.3390/jof7090680	2021
	Interspecies metabolite transfer fuels the methionine metabolism of Fusobacterium nucleatum to stimulate volatile methyl mercaptan production.	Hara T, Sakanaka A, Lamont RJ, Amano A, Kuboniwa M.	mSystems	10.1128/msystems.00764-23	2024
	Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites.	Munir A, Marovic D, Nogueira LP, Simm R, Naemi AO, Landro SM, Helgerud M, Zheng K, Par M, Taubock TT, Attin T, Tarle Z, Boccaccini AR, Haugen HJ.	Pharmaceutics	10.3390/pharmaceutics14102241	2022
	An In Vitro Evaluation of Denture Cleansing Regimens against a Polymicrobial Denture Biofilm Model.	Brown JL, Young T, McKloud E, Butcher MC, Bradshaw D, Pratten JR, Ramage G.	Antibiotics (Basel)	10.3390/antibiotics11010113	2022
	New Evidences of Antibacterial Effects of Cranberry Against Periodontal Pathogens.	Sanchez MC, Sanchez MC, Ribeiro-Vidal H, Bartolome B, Figuero E, Moreno-Arribas MV, Sanz M, Herrera D.	Foods	10.3390/foods9020246	2020
	Evaluation of photosensitizer-containing superhydrophobic surfaces for the antibacterial treatment of periodontal biofilms.	Tonon CC, Ashraf S, de Souza Rastelli AN, Ghosh G, Hasan T, Xu Q, Greer A, Lyons AM.	J Photochem Photobiol B	10.1016/j.jphotobiol.2022.112458	2022
Pathogenicity	Antimicrobial Activity of EPA and DHA against Oral Pathogenic Bacteria Using an In Vitro Multi-Species Subgingival Biofilm Model.	Ribeiro-Vidal H, Sanchez MC, Sanchez MC, Alonso-Espanol A, Figuero E, Ciudad MJ, Collado L, Herrera D, Sanz M.	Nutrients	10.3390/nu12092812	2020
Transcriptome	Gene expression of Porphyromonas gingivalis ATCC 33277 when growing in an in vitro multispecies biofilm.	Romero-Lastra P, Sanchez MC, Sanchez MC, Llama-Palacios A, Figuero E, Herrera D, Sanz M.	PLoS One	10.1371/journal.pone.0221234	2019
Pathogenicity	Antimicrobial activity of red wine and oenological extracts against periodontal pathogens in a validated oral biofilm model.	Sanchez MC, Sanchez MC, Ribeiro-Vidal H, Esteban-Fernandez A, Bartolome B, Figuero E, Moreno-Arribas MV, Sanz M, Herrera D.	BMC Complement Altern Med	10.1186/s12906-019-2533-5	2019
	Chemical Constituents and Antileishmanial and Antibacterial Activities of Essential Oils from Scheelea phalerata.	Oliveira DM, Furtado FB, Gomes AAS, Belut BR, Nascimento EA, Morais SAL, Martins CHG, Santos VCO, da Silva CV, Teixeira TL, Cunha LCS, Oliveira A, de Aquino FJT.	ACS Omega	10.1021/acsomega.9b01962	2020
	Evaluation of antimicrobial activity of extracts of Tibouchina candolleana (melastomataceae), isolated compounds and semi-synthetic derivatives against endodontic bacteria.	Dos Santos FM, de Souza MG, Crotti AE, Martins CH, Ambrosio SR, Veneziani RC, E Silva ML, Cunha WR.	Braz J Microbiol	10.1590/s1517-83822012000200045	2012
	Evaluating Streptococcus mutans Strain Dependent Characteristics in a Polymicrobial Biofilm Community.	Zhou Y, Millhouse E, Shaw T, Lappin DF, Rajendran R, Bagg J, Lin H, Ramage G.	Front Microbiol	10.3389/fmicb.2018.01498	2018
Pathogenicity	Effects of fruit and vegetable low molecular mass fractions on gene expression in gingival cells challenged with Prevotella intermedia and Actinomyces naeslundii.	Canesi L, Borghi C, Stauder M, Lingstrom P, Papetti A, Pratten J, Signoretto C, Spratt DA, Wilson M, Zaura E, Pruzzo C.	J Biomed Biotechnol	10.1155/2011/230630	2011
	Antimicrobial Constituents of Artemisia afra Jacq. ex Willd. against Periodontal Pathogens.	More G, Lall N, Hussein A, Tshikalange TE.	Evid Based Complement Alternat Med	10.1155/2012/252758	2012
	Chemical Constituents and Evaluation of Antimicrobial and Cytotoxic Activities of Kielmeyera coriacea Mart. & Zucc. Essential Oils.	Martins Cde M, do Nascimento EA, de Morais SA, de Oliveira A, Chang R, Cunha LC, Martins MM, Martins CH, Moraes Tda S, Rodrigues PV, da Silva CV, de Aquino FJ.	Evid Based Complement Alternat Med	10.1155/2015/842047	2015
Pathogenicity	A Bioengineered Nisin Derivative To Control Streptococcus uberis Biofilms.	Perez-Ibarreche M, Field D, Ross RP, Hill C.	Appl Environ Microbiol	10.1128/aem.00391-21	2021
Pathogenicity	Antimicrobial activity of diterpenes from Viguiera arenaria against endodontic bacteria.	Carvalho TC, Simao MR, Ambrosio SR, Furtado NA, Veneziani RC, Heleno VC, Da Costa FB, Gomes BP, Souza MG, Borges dos Reis E, Martins CH.	Molecules	10.3390/molecules160100543	2011
Pathogenicity	Antibacterial activity of dental composites containing zinc oxide nanoparticles.	Aydin Sevinc B, Hanley L.	J Biomed Mater Res B Appl Biomater	10.1002/jbm.b.31620	2010
	Chemical Analysis and Study of Phenolics, Antioxidant Activity, and Antibacterial Effect of the Wood and Bark of Maclura tinctoria (L.) D. Don ex Steud.	Lamounier KC, Cunha LC, de Morais SA, de Aquino FJ, Chang R, do Nascimento EA, de Souza MG, Martins CH, Cunha WR.	Evid Based Complement Alternat Med	10.1155/2012/451039	2012
	Seasonal variation of the chemical composition and antimicrobial and cytotoxic activities of the essential oils from Inga laurina (Sw.) Willd.	Furtado FB, de Aquino FJ, Nascimento EA, de M Martins C, de Morais SA, Chang R, Cunha LC, Leandro LF, Martins CH, Martins MM, da Silva CV, Machado FC, de Oliveira A.	Molecules	10.3390/molecules19044560	2014
	Interkingdom interactions on the denture surface: Implications for oral hygiene.	Delaney C, O'Donnell LE, Kean R, Sherry L, Brown JL, Calvert G, Nile CJ, Cross L, Bradshaw DJ, Brandt BW, Robertson D, Ramage G.	Biofilm	10.1016/j.bioflm.2019.100002	2019
Metabolism	Diffusion of macromolecules in model oral biofilms.	Takenaka S, Pitts B, Trivedi HM, Stewart PS.	Appl Environ Microbiol	10.1128/aem.02279-08	2009
	Candida albicans as an Essential "Keystone" Component within Polymicrobial Oral Biofilm Models?	Young T, Alshanta OA, Kean R, Bradshaw D, Pratten J, Williams C, Woodall C, Ramage G, Brown JL.	Microorganisms	10.3390/microorganisms9010059	2020
Metabolism	Comparison of cell-associated phosphate in Actinomyces israelii ATCC 12103 and Actinomyces naeslundii ATCC 19039.	Coles RS, Shovlin FE.	Clin Prev Dent		1986
	Viable Compositional Analysis of an Eleven Species Oral Polymicrobial Biofilm.	Sherry L, Lappin G, O'Donnell LE, Millhouse E, Millington OR, Bradshaw DJ, Axe AS, Williams C, Nile CJ, Ramage G.	Front Microbiol	10.3389/fmicb.2016.00912	2016
Pathogenicity	Validation of ATP bioluminescence as a tool to assess antimicrobial effects of mouthrinses in an in vitro subgingival-biofilm model.	Sanchez MC, Sanchez MC, Llama-Palacios A, Marin MJ, Figuero E, Leon R, Blanc V, Herrera D, Sanz M.	Med Oral Patol Oral Cir Bucal	10.4317/medoral.18376	2013
Pathogenicity	Direct visualization of spatial and temporal patterns of antimicrobial action within model oral biofilms.	Takenaka S, Trivedi HM, Corbin A, Pitts B, Stewart PS.	Appl Environ Microbiol	10.1128/aem.02218-07	2008
Pathogenicity	Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria.	Souza AB, de Souza MG, Moreira MA, Moreira MR, Furtado NA, Martins CH, Bastos JK, dos Santos RA, Heleno VC, Ambrosio SR, Veneziani RC.	Molecules	10.3390/molecules16119611	2011
	Enamel Carious Lesion Development in Response to Sucrose and Fluoride Concentrations and to Time of Biofilm Formation: An Artificial-Mouth Study.	Arthur RA, Kohara EK, Waeiss RA, Eckert GJ, Zero D, Ando M.	J Oral Dis	10.1155/2014/348032	2014
Pathogenicity	Antimicrobial penetration and efficacy in an in vitro oral biofilm model.	Corbin A, Pitts B, Parker A, Stewart PS.	Antimicrob Agents Chemother	10.1128/aac.00206-11	2011
Metabolism	Periodontal pathogens produce quorum sensing signal molecules.	Frias J, Olle E, Alsina M.	Infect Immun	10.1128/iai.69.5.3431-3434.2001	2001
	Conservation of an Actinomyces viscosus T14V type 1 fimbrial subunit homolog among divergent groups of Actinomyces spp.	Yeung MK.	Infect Immun	10.1128/iai.60.3.1047-1054.1992	1992
Pathogenicity	Phevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression.	Secor PR, Jennings LK, James GA, Kirker KR, Pulcini ED, McInnerney K, Gerlach R, Livinghouse T, Hilmer JK, Bothner B, Fleckman P, Olerud JE, Stewart PS.	PLoS One	10.1371/journal.pone.0040973	2012
	In vitro activity of A-16686, a potential antiplaque agent.	Pallanza R, Scotti R, Beretta G, Cavalleri B, Arioli V.	Antimicrob Agents Chemother	10.1128/aac.26.4.462	1984
	Lactose-reversible coaggregation between oral actinomycetes and Streptococcus sanguis.	Kolenbrander PE, Williams BL.	Infect Immun	10.1128/iai.33.1.95-102.1981	1981
	The potential bactericidal effect of oral probiotics on extrinsic black stain-associated bacteria in children: An in-vitro and in-vivo study.	Wahba N, Sharaf D, Wagdy M, El-Motayam A, Nagi B.	J Dent Sci	10.1016/j.jds.2025.04.032	2025
	Antibacterial Effect of Copaifera duckei Dwyer Oleoresin and Its Main Diterpenes against Oral Pathogens and Their Cytotoxic Effect.	Abrao F, Alves JA, Andrade G, de Oliveira PF, Ambrosio SR, Veneziani RCS, Tavares DC, Bastos JK, Martins CHG	Front Microbiol	10.3389/fmicb.2018.00201	2018
Pathogenicity	Systematic screening of plant extracts from the Brazilian Pantanal with antimicrobial activity against bacteria with cariogenic relevance.	Brighenti FL, Salvador MJ, Delbem AC, Delbem AC, Oliveira MA, Soares CP, Freitas LS, Koga-Ito CY	Caries Res	10.1159/000357225	2014
Pathogenicity	Interactions between salivary Bifidobacterium adolescentis and other oral bacteria: in vitro coaggregation and coadhesion assays.	Nagaoka S, Hojo K, Murata S, Mori T, Ohshima T, Maeda N	FEMS Microbiol Lett	10.1111/j.1574-6968.2008.01092.x	2008
	In Vitro Anti-Biofilm and Antibacterial Properties of Streptococcus downii sp. nov.	Cuenca M, Sanchez MC, Diz P, Martinez-Lamas L, Alvarez M, Limeres J, Sanz M, Herrera D.	Microorganisms	10.3390/microorganisms9020450	2021

References

#6829	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 17233
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#37076	; Curators of the CIP;
#52676	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 35337
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#68379	Automatically annotated from API Coryne .
#68380	Automatically annotated from API rID32A .
#68381	Automatically annotated from API rID32STR .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#121220	Collection of Institut Pasteur ; Curators of the CIP; CIP 100654
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Actinomyces naeslundii (DSM 17233, ATCC 19039, CCUG 35337)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Halophily

Metabolite utilization

Antibiotic resistance

Metabolite production

Metabolite tests

Enzymes

API coryne

API zym

API 50CHac

API rID32A

API rID32STR

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

16S sequences

Genome-based predictions

Literature

Literature

References

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