Actinomyces israelii (DSM 43320, ATCC 12102, JCM 12964)

Name: Actinomyces israelii (DSM 43320, ATCC 12102, JCM 12964)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 151

Type strain

Strain Designation Jr 277 (CDC W855)

Culture col. no. DSM 43320 ATCC 12102 JCM 12964 CCUG 18307 IMET 10792 7 more

NCBI tax ID(s) 1120944 1659

Special Collections DSMZ CCUG JCM KCTC CIP

History <- M. A. Gerencser; WVU 46 <- ATCC; ATCC 12102 <- A. Howell, NIH; NIH 277 DSM 43320 <-- M. A. Gerencser WVU 46 <-- ATCC 12102 <-- A. Howell NIH 277. CIP <- 1988, ATCC <- A. Howell: strain Jr 277 (CDC W855)

Links

Actinomyces israelii Jr 277 is an anaerobe, Gram-positive, rod-shaped bacterium that was isolated from human brain abscess.

Gram-positive rod-shaped anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 35496

ATCC 12102,CCUG 18307,IMET 10792,DSM 43320,CCUG 2271,CIP 103259,NCTC 12972,IMET 10972,JCM 12964

@ref 20215

Last LPSN update 2026-02-09 11:17:48

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Actinomycetales

Family Actinomycetaceae

Genus Actinomyces

Species Actinomyces israelii

Full scientific name Actinomyces israelii (Kruse 1896) Lachner-Sandoval 1898 (Approved Lists 1980)

Synonyms (2)

"Actinobacterium israeli"
"Streptothrix israeli"

BacDive ID	Other strains from **Actinomyces israelii** (36)	Type strain
150	A. israelii CCUG 34702, DSM 43011, ATCC 10048, NHI 1829
152	A. israelii DSM 43323, WVU 339
105476	A. israelii STI09064(IMET), 1110-009,
105477	A. israelii STI09079(IMET), 1141-014,
135348	A. israelii B1, CIP 53.109
136339	A. israelii CIP 104730, CCUG 4867, NCTC 4860
137141	A. israelii 1912, CIP 60.40
137277	A. israelii CIP 104876, NCTC 10236, CCUG 34502
138098	A. israelii CIP 104874, NCTC 6826, CCUG 34495
138099	A. israelii CCUG 34501, CIP 104875, NCTC 10215
141881	A. israelii CCUG 8060
146033	A. israelii CCUG 30217
147537	A. israelii CCUG 33763
147818	A. israelii CCUG 34284, ATCC 12597
147919	A. israelii CCUG 34496, NCTC 6827
147920	A. israelii CCUG 34497, NCTC 6830
147921	A. israelii CCUG 34498, NCTC 6831
147922	A. israelii CCUG 34499, NCTC 8047
147923	A. israelii CCUG 34500, NCTC 8439
147946	A. israelii CCUG 34556
147947	A. israelii CCUG 34557
148445	A. israelii CCUG 35455
148548	A. israelii CCUG 35624
148770	A. israelii CCUG 35922
148771	A. israelii CCUG 35923
148772	A. israelii CCUG 35924
148773	A. israelii CCUG 35925
148774	A. israelii CCUG 35926
149130	A. israelii CCUG 36904
149131	A. israelii CCUG 36905
149316	A. israelii CCUG 37486 C
149320	A. israelii CCUG 37496
152583	A. israelii CCUG 47135
154406	A. israelii CCUG 53438
154704	A. israelii CCUG 54890
156688	A. israelii CCUG 64147

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
120287	positive	rod-shaped
125438			93.875
125439			94.2
125439	positive		98.9

Colony morphology

@ref	Incubation period
46802	2-3 days
120287

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
40615	MEDIUM 39 - for Actinomyces		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
10954	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
10954	BBL ACTINOMYCES BROTH (DSMZ Medium 1029)	Medium recipe at MediaDive	Name: BBL ACTINOMYCES BROTH (DSMZ Medium 1029) Composition: Infusion Broth 1.425 g/l Potassium Phosphate 0.855 g/l Dextrose 0.285 g/l Yeast extract 0.285 g/l Pancreatic digest of casein 0.228 g/l L-Cysteine HCl 0.057 g/l Starch 0.057 g/l Ammonium Sulfate 0.057 g/l Magnesium sulfate 0.0114 g/l Calcium Chloride 0.00057 g/l Distilled water
120287	CIP Medium 6	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
10954	positive	growth	37
40615	positive	growth	37
46802	positive	growth	37
67770	positive	growth	37
120287	positive	growth	30-37
120287	negative	growth	10
120287	negative	growth	25
120287	negative	growth	41
120287	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
10954	anaerobe
46802	anaerobe
120287	facultative anaerobe
125439	microaerophile	91.1

Spore formation

@ref	Spore formation	Confidence
125439		90.9

Halophily

@ref	Salt	Growth	Tested relation	Concentration
120287	NaCl	positive	growth	0-4 %
120287	NaCl		growth	6 %
120287	NaCl		growth	8 %
120287	NaCl		growth	10 %

Murein

@ref	Murein short key	Type
10954	A11.52	A5alpha L-Lys-L-Lys-D-Asp

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
120287	16947 ChEBI	citrate	-	carbon source
68377	15824 ChEBI	D-fructose	+	builds acid from	from API NH
68377	17634 ChEBI	D-glucose	+	builds acid from	from API NH
68379	16899 ChEBI	D-mannitol	-	fermentation	from API Coryne
68379	16988 ChEBI	D-ribose	-	fermentation	from API Coryne
68379	65327 ChEBI	D-xylose	-	fermentation	from API Coryne
68379	4853 ChEBI	esculin	-	hydrolysis	from API Coryne
120287	4853 ChEBI	esculin	-	hydrolysis
68379	5291 ChEBI	gelatin	-	hydrolysis	from API Coryne
68379	28087 ChEBI	glycogen	-	fermentation	from API Coryne
120287	606565 ChEBI	hippurate	-	hydrolysis
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68379	17716 ChEBI	lactose	-	fermentation	from API Coryne
68379	17306 ChEBI	maltose	-	fermentation	from API Coryne
68377	17306 ChEBI	maltose	+	builds acid from	from API NH
68379	17632 ChEBI	nitrate	-	reduction	from API Coryne
120287	17632 ChEBI	nitrate	+	reduction
120287	17632 ChEBI	nitrate	-	respiration
120287	16301 ChEBI	nitrite	-	reduction
68377	18257 ChEBI	ornithine	-	degradation	from API NH
68380	16634 ChEBI	raffinose	+	fermentation	from API rID32A
68379	17992 ChEBI	sucrose	+	fermentation	from API Coryne
68377	17992 ChEBI	sucrose	-	builds acid from	from API NH
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68377	27897 ChEBI	tryptophan	-	energy source	from API NH
68379	16199 ChEBI	urea	-	hydrolysis	from API Coryne
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A
68377	16199 ChEBI	urea	-	hydrolysis	from API NH

Metabolite production

@ref	Chebi-ID	Metabolite
68380	35581 ChEBI	indole	from API rID32A
68377	35581 ChEBI	indole	from API NH
120287	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test	Voges-proskauer-test	Methylred-test
120287	15688 ChEBI	acetoin		-
120287	17234 ChEBI	glucose			-
68380	35581 ChEBI	indole	-			from API rID32A
68377	35581 ChEBI	indole	-			from API NH

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	-	3.1.3.2	from API zym
120287	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68379	alkaline phosphatase	+	3.1.3.1	from API Coryne
68377	alkaline phosphatase	-	3.1.3.1	from API NH
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68380	alpha-glucosidase	+	3.2.1.20	from API rID32A
68379	alpha-glucosidase	+	3.2.1.20	from API Coryne
68382	alpha-mannosidase	-	3.2.1.24	from API zym
120287	amylase	+
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68382	beta-galactosidase	+	3.2.1.23	from API zym
120287	beta-galactosidase	-	3.2.1.23
68379	beta-galactosidase	-	3.2.1.23	from API Coryne
68377	beta-galactosidase	-	3.2.1.23	from API NH
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68382	beta-glucosidase	+	3.2.1.21	from API zym
68380	beta-glucosidase	+	3.2.1.21	from API rID32A
68379	beta-glucosidase	-	3.2.1.21	from API Coryne
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68379	beta-glucuronidase	-	3.2.1.31	from API Coryne
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
68377	beta-lactamase	-	3.5.2.6	from API NH
120287	caseinase	-	3.4.21.50
120287	catalase	+	1.11.1.6
68379	catalase	-	1.11.1.6	from API Coryne
68382	cystine arylamidase	-	3.4.11.3	from API zym
120287	DNase	-
68382	esterase (C 4)	-		from API zym
68382	esterase lipase (C 8)	-		from API zym
120287	gamma-glutamyltransferase	-	2.3.2.2
68377	gamma-glutamyltransferase	-	2.3.2.2	from API NH
120287	gelatinase	-
68379	gelatinase	-		from API Coryne
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
120287	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
68380	leucine arylamidase	+	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
120287	lipase	-
68377	lipase	-		from API NH
68382	lipase (C 14)	-		from API zym
120287	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68379	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API Coryne
68382	naphthol-AS-BI-phosphohydrolase	-		from API zym
120287	ornithine decarboxylase	-	4.1.1.17
68377	ornithine decarboxylase	-	4.1.1.17	from API NH
120287	oxidase	-
120287	phenylalanine ammonia-lyase	-	4.3.1.24
68380	phenylalanine arylamidase	+		from API rID32A
68377	proline-arylamidase	+	3.4.11.5	from API NH
68380	proline-arylamidase	+	3.4.11.5	from API rID32A
68379	pyrazinamidase	+	3.5.1.B15	from API Coryne
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68379	pyrrolidonyl arylamidase	-	3.4.19.3	from API Coryne
68382	trypsin	-	3.4.21.4	from API zym
120287	tryptophan deaminase	-
68377	tryptophan deaminase	-	4.1.99.1	from API NH
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
120287	tween esterase	-
68380	tyrosine arylamidase	+		from API rID32A
120287	urease	-	3.5.1.5
68380	urease	-	3.5.1.5	from API rID32A
68377	urease	-	3.5.1.5	from API NH
68379	urease	-	3.5.1.5	from API Coryne
68382	valine arylamidase	-		from API zym

API coryne

@ref	Reduction of nitrateNIT	PYZ	PYRA	PAL	beta GUR	beta GAL	alpha GLU	beta NAG	ESC	URE	GEL	Control fermentationControl	GLU	RIB	XYL	MAN	MAL	LAC	SAC	GLYG	CAT
46802	-	+	-	+	-	-	+	-	-	-	-	-	not determinedn.d.	-	-	-	-	-	+	-	-

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
120287	-	-	-	-	-	+	-	-	-	-	-	-	-	+	-	+	+	-	-	-

API NH

@ref	PEN	GLU	FRU	MAL	SAC	ODC	URE	LIP	PAL	beta GAL	ProA	GGT	IND
46802	-	+	+	+	-	-	-	-	-	-	+	-	-

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
10954	-	-	-	+	-	+	+	+	-	-	+/-	+	-	-	+	-	-	-	+	-	+	+	-	+	-	-	-	-	-
10954	-	-	+/-	+	-	+	+	+	-	-	+	+	-	-	-	-	-	-	+	-	+	+	-	+	-	-	-	-	-
10954	-	-	+/-	+/-	-	+	+	+/-	-	-	+	+	-	-	+	-	-	+/-	+	-	+	+	-	+	+	+	+/-	-	+/-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body-Site	#Organ	#Brain
#Host Body-Site	#Other	#Abscess
#Infection	#Patient	-

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
10954	human brain abscess
46802	Human brain abscess	MN,Rochester	USA	USA	North America
67770	Human brain abscess
120287	Human, Brain abscess	Rochester, Minnesota	United States of America	USA	North America

Taxonmaps

69479

Global distribution of 16S sequence X82450 (>99% sequence identity) for Actinomyces israelii subclade from Microbeatlas

Aquatic Samples	282
Soil Samples	91
Animal Samples	11935
Plant Samples	50
Total Samples	12358

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
10954	2	Risk group (German classification) According to TRBA 466
120287	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM71196v1 assembly for Actinomyces israelii DSM 43320	scaffold	GCA_000711965	1120944.3	2565956542	1120944	58.1
67770	50279_H01 assembly for Actinomyces israelii	complete	GCA_900637225	1659.4	2843235134	1659	24.41

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Actinomyces israelii strain ATCC 12102 16S ribosomal RNA gene, partial sequence	AF058042	280	1659
20218	A.israelii 16S rRNA gene	X82450	1441	1659
20218	Actinomyces israelii gene for 16S ribosomal RNA, partial sequence, strain: JCM 12964	AB849123	1512	1659

GC content

67770

GC-content (mol%)70

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Actinomyces israelii NCTC12972
IMG: 2843235134

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	microaerophile	91.10	no
125439	gram_stain	BacteriaNetⓘ	positive	98.90	no
125439	motility	BacteriaNetⓘ	no	94.20	no
125439	spore_formation	BacteriaNetⓘ	no	90.90	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Actinomyces israelii strain NCTC12972
PATRIC: 1659.4

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	89.03	no
125438	anaerobic	anaerobicⓘ	no	68.46	no
125438	spore-forming	spore-formingⓘ	no	85.16	no
125438	aerobic	aerobicⓘ	no	85.53	yes
125438	thermophilic	thermophileⓘ	no	93.86	no
125438	flagellated	motile2+ⓘ	no	93.88	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Fluorescence Spectroscopy Shows Porphyrins Produced by Cultured Oral Bacteria Differ Depending on Composition of Growth Media.	Lennon AM, Brune L, Techert S, Buchalla W.	Caries Res	10.1159/000528731	2023
	Metatranscriptomic analysis shows functional alterations in subgingival biofilm in young smokers with periodontitis: a pilot study.	Casarin RCV, Silva RVCD, Paz HES, Stolf CS, Carvalho LM, Noronha MF, Sallum AW, Monteiro MF.	J Appl Oral Sci	10.1590/1678-7757-2024-0031	2024
	Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus.	Uchida-Fukuhara Y, Shimamura S, Sawafuji R, Nishiuchi T, Yoneda M, Ishida H, Matsumura H, Tsutaya T.	Sci Rep	10.1038/s41598-024-55779-y	2024
Phylogeny	Denaturing gradient gel electrophoresis as a diagnostic tool in periodontal microbiology.	Zijnge V, Welling GW, Degener JE, van Winkelhoff AJ, Abbas F, Harmsen HJ.	J Clin Microbiol	10.1128/jcm.00122-06	2006
	Antibiofilm efficacy of plant extracts as root canal irrigants in endodontics: a systematic literature review.	Diouchi J, Toure B, Ghoul S.	Front Dent Med	10.3389/fdmed.2024.1479953	2024
	Zinc Phosphate Microparticles against Nosocomial and Oral Bacteria: Synthesis, Analytical Characterization, and Biocompatibility.	Reyes-Carmona L, Izzi M, Picca RA, Sportelli MC, Prado-Prone G, Silva-Bermudez P, Rodil SE, Cioffi N, Almaguer-Flores A.	ACS Omega	10.1021/acsomega.5c02071	2025
	Novel pulp capping material based on sodium trimetaphosphate: synthesis, characterization, and antimicrobial properties.	Franzin NRS, Sostena MMDS, Santos ADD, Moura MR, Camargo ER, Hosida TY, Delbem ACB, Moraes JCS.	J Appl Oral Sci	10.1590/1678-7757-2021-0483	2022
	Synergistic antimicrobial potential of EGCG and fosfomycin against biofilms associated with endodontic infections.	Duque C, Souza ACA, Aida KL, Pereira JA, Caiaffa KS, Santos VRD, Cosme-Silva L, Prakki A.	J Appl Oral Sci	10.1590/1678-7757-2022-0282	2023
	Antimicrobial Activity of Methylene Blue Associated with Photodynamic Therapy: In Vitro Study in Multi-Species Oral Biofilm.	Bueno-Silva B, Parma-Garcia J, Frigo L, Suarez LJ, Macedo TT, Uyeda FH, Melo MARDC, Sacco R, Mourao CF, Feres M, Shibli JA, Figueiredo LC.	Pathogens	10.3390/pathogens13040342	2024
	Evaluation of the Microbial Profile on the Polydioxanone Membrane and the Collagen Membrane Exposed to Multi-Species Subgingival Biofilm: An In Vitro Study.	Cintra Moreira MV, Figueiredo LC, da Cunha Melo MAR, Uyeda FH, da Silva LDA, Macedo TT, Sacco R, Mourao CF, Shibli JA, Bueno-Silva B.	Membranes (Basel)	10.3390/membranes13120907	2023
	Microbiological Properties and Cytotoxicity of PNVCL Hydrogels Containing Flavonoids as Intracanal Medication for Endodontic Therapy.	Braga GPA, Caiaffa KS, Pereira JA, Santos VRD, Souza ACA, Ribeiro LDS, Camargo ER, Prakki A, Duque C.	J Funct Biomater	10.3390/jfb13040305	2022
	In vitro evaluation of membranes for regenerative procedures against oral bacteria.	Gil ACK, Prado MM, Rocha LRD, Benfatti C, Schuldt Filho G, Almeida J.	Braz Dent J	10.1590/0103-6440202305060	2023
	Lactobacillus acidophilus impairs the establishment of pathogens in a subgingival multispecies biofilm.	Bueno MR, Dudu-Silva G, Macedo TT, Gomes APAP, Rodrigues Oliveira Braga A, Aguiar Silva LD, Bueno-Silva B.	Front Dent Med	10.3389/fdmed.2023.1212773	2023
	Activity of five antimicrobial peptides against periodontal as well as non-periodontal pathogenic strains.	Enigk K, Jentsch H, Rodloff AC, Eschrich K, Stingu CS.	J Oral Microbiol	10.1080/20002297.2020.1829405	2020
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Pathogenicity	Antibacterial Activity of a Bioactive Tooth-Coating Material Containing Surface Pre-Reacted Glass in a Complex Multispecies Subgingival Biofilm.	Tanaka CJ, Rodrigues JA, Pingueiro JMS, Macedo TT, Feres M, Shibli JA, Bueno-Silva B.	Pharmaceutics	10.3390/pharmaceutics15061727	2023
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	Analytical Performance Characteristics of a New Transcription-Mediated Amplification Assay for Treponema pallidum.	Getman D, Lin M, Barakat N, Skvoretz R, Godornes C, Swenson P, Nenninger A, Golden MR, Lukehart SA.	J Clin Microbiol	10.1128/jcm.00511-21	2021
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Pathogenicity	Antimicrobial activity of NO-releasing compounds against periodontal pathogens.	Shim JS, Park DS, Baek DH, Jha N, Park SI, Yun HJ, Kim WJ, Ryu JJ.	PLoS One	10.1371/journal.pone.0199998	2018
	Scardovia wiggsiae and its potential role as a caries pathogen.	Kressirer CA, Smith DJ, King WF, Dobeck JM, Starr JR, Tanner ACR.	J Oral Biosci	10.1016/j.job.2017.05.002	2017
	Short-term antimicrobial properties of mineral trioxide aggregate with incorporated silver-zeolite.	Odabas ME, Cinar C, Akca G, Araz I, Ulusu T, Yucel H.	Dent Traumatol	10.1111/j.1600-9657.2011.00986.x	2011
	Metabolic activity of hydro-carbon-oxo-borate on a multispecies subgingival periodontal biofilm: a short communication.	Shibli JA, Rocha TF, Coelho F, de Oliveira Capote TS, Saska S, Melo MA, Pingueiro JMS, de Faveri M, Bueno-Silva B.	Clin Oral Investig	10.1007/s00784-021-03900-0	2021
Pathogenicity	The Comparative Evaluation of the Antimicrobial Effect of Propolis with Chlorhexidine against Oral Pathogens: An In Vitro Study.	Akca AE, Akca G, Topcu FT, Macit E, Pikdoken L, Ozgen IS.	Biomed Res Int	10.1155/2016/3627463	2016
Phylogeny	Evaluation of the new Vitek 2 ANC card for identification of medically relevant anaerobic bacteria.	Mory F, Alauzet C, Matuszeswski C, Riegel P, Lozniewski A.	J Clin Microbiol	10.1128/jcm.01778-08	2009
	An in vitro biofilm model of subgingival plaque.	Walker C, Sedlacek MJ.	Oral Microbiol Immunol	10.1111/j.1399-302x.2007.00336.x	2007
	Photodynamic treatment of endodontic polymicrobial infection in vitro.	Fimple JL, Fontana CR, Foschi F, Ruggiero K, Song X, Pagonis TC, Tanner AC, Kent R, Doukas AG, Stashenko PP, Soukos NS.	J Endod	10.1016/j.joen.2008.03.011	2008
Metabolism	Cariogenic actinomyces identified with a beta-glucosidase-dependent green color reaction to Gardenia jasminoides extract.	Chen L, Ma L, Park NH, Shi W.	J Clin Microbiol	10.1128/jcm.39.8.3009-3012.2001	2001
Phylogeny	Development of amplified 16S ribosomal DNA restriction analysis for identification of Actinomyces species and comparison with pyrolysis-mass spectrometry and conventional biochemical tests.	Hall V, O'Neill GL, Magee JT, Duerden BI.	J Clin Microbiol	10.1128/jcm.37.7.2255-2261.1999	1999
	Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model.	Soares GM, Teles F, Starr JR, Feres M, Patel M, Martin L, Teles R.	Antimicrob Agents Chemother	10.1128/aac.04974-14	2015
Enzymology	pH gradient and distribution of streptococci, lactobacilli, prevotellae, and fusobacteria in carious dentine.	Kianoush N, Nguyen KA, Browne GV, Simonian M, Hunter N.	Clin Oral Investig	10.1007/s00784-013-1009-0	2014
	The vaginal microflora in relation to gingivitis.	Persson R, Hitti J, Verhelst R, Vaneechoutte M, Persson R, Hirschi R, Weibel M, Rothen M, Temmerman M, Paul K, Eschenbach D.	BMC Infect Dis	10.1186/1471-2334-9-6	2009
	Design and evaluation of useful bacterium-specific PCR primers that amplify genes coding for bacterial 16S rRNA.	Marchesi JR, Sato T, Weightman AJ, Martin TA, Fry JC, Hiom SJ, Dymock D, Wade WG.	Appl Environ Microbiol	10.1128/aem.64.2.795-799.1998	1998
	Persistence of associated gram-negative bacteria in experimental actinomycotic lesions in mice.	Jordan HV, Kelly DM.	Infect Immun	10.1128/iai.40.2.847-849.1983	1983
Pathogenicity	Novel riboswitch-binding flavin analog that protects mice against Clostridium difficile infection without inhibiting cecal flora.	Blount KF, Megyola C, Plummer M, Osterman D, O'Connell T, Aristoff P, Quinn C, Chrusciel RA, Poel TJ, Schostarez HJ, Stewart CA, Walker DP, Wuts PG, Breaker RR.	Antimicrob Agents Chemother	10.1128/aac.01282-15	2015
	Evaluation of the analytical performance of the Xpert MTB/RIF assay.	Blakemore R, Story E, Helb D, Kop J, Banada P, Owens MR, Chakravorty S, Jones M, Alland D.	J Clin Microbiol	10.1128/jcm.00128-10	2010
	Evaluation of the oxyrase OxyPlate anaerobe incubation system.	Wiggs LS, Cavallaro JJ, Miller JM.	J Clin Microbiol	10.1128/jcm.38.2.499-507.2000	2000
Enzymology	Use of synthetic oligonucleotide DNA probes for identification and direct detection of Bacteroides forsythus in plaque samples.	Moncla BJ, Motley ST, Braham P, Ewing L, Adams TH, Vermeulen NM.	J Clin Microbiol	10.1128/jcm.29.10.2158-2162.1991	1991
Phylogeny	Determination and analysis of Actinomyces israelii serotypes by fluorescent-antibody procedures.	Brock DW, Georg LK.	J Bacteriol	10.1128/jb.97.2.581-588.1969	1969
	Morphological, biochemical, and serological studies on 64 strains of Actinomyces israelii.	Slack JM, Landfried S, Gerencser MA.	J Bacteriol	10.1128/jb.97.2.873-884.1969	1969
Phylogeny	Two new serological groups of Actinomyces.	Slack JM, Gerencser MA.	J Bacteriol	10.1128/jb.103.1.265-266.1970	1970
Enzymology	Quantitative microbiological study of human carious dentine by culture and real-time PCR: association of anaerobes with histopathological changes in chronic pulpitis.	Martin FE, Nadkarni MA, Jacques NA, Hunter N.	J Clin Microbiol	10.1128/jcm.40.5.1698-1704.2002	2002
	Multigeneric aggregations among oral bacteria: a network of independent cell-to-cell interactions.	Kolenbrander PE, Andersen RN.	J Bacteriol	10.1128/jb.168.2.851-859.1986	1986
Phylogeny	Motile nocardoid Actinomycetales.	Sukapure RS, Lechevalier MP, Reber H, Higgins ML, Lechevalier HA, Prauser H.	Appl Microbiol	10.1128/am.19.3.527-533.1970	1970
Metabolism	Sanguicin, a bacteriocin of oral Streptococcus sanguis.	Fujimura S, Nakamura T.	Antimicrob Agents Chemother	10.1128/aac.16.3.262	1979
Metabolism	Production, purification, and properties of a bacteriocin from Staphylococcus aureus isolated from saliva.	Nakamura T, Yamazaki N, Taniguchi H, Fujimura S.	Infect Immun	10.1128/iai.39.2.609-614.1983	1983
	Conservation of an Actinomyces viscosus T14V type 1 fimbrial subunit homolog among divergent groups of Actinomyces spp.	Yeung MK.	Infect Immun	10.1128/iai.60.3.1047-1054.1992	1992
	PCR primers and probes for the 16S rRNA gene of most species of pathogenic bacteria, including bacteria found in cerebrospinal fluid.	Greisen K, Loeffelholz M, Purohit A, Leong D.	J Clin Microbiol	10.1128/jcm.32.2.335-351.1994	1994
Phylogeny	IDENTIFICATION OF SPECIES OF ACTINOMYCES.	GEORG LK, ROBERTSTAD GW, BRINKMAN SA.	J Bacteriol	10.1128/jb.88.2.477-490.1964	1964
Metabolism	Ability of oral bacteria to degrade fibronectin.	Wikstrom M, Linde A.	Infect Immun	10.1128/iai.51.2.707-711.1986	1986
Enzymology	Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study.	Gao W, Weng J, Gao Y, Chen X.	BMC Infect Dis	10.1186/1471-2334-13-271	2013
	[Initial study on the discrimination of oral common Actinomycetes with metabonomics method].	Li MY, Guo Q, Zhou XD, Xiong P, Jia XM, Xiao XR, Li W, Xiao LY	Hua Xi Kou Qiang Yi Xue Za Zhi		2009
Cultivation	Production of antagonistic substance by Eikenella corrodens isolated from the oral cavity of human beings with and without periodontal disease.	Apolonio AC, Carvalho MA, Ribas RN, Sousa-Gaia LG, Santos KV, Lana MA, Nicoli JR, Farias LM	J Appl Microbiol	10.1111/j.1365-2672.2006.03211.x	2007
	[Transmission electron microscopic studies of fine structure by fast freeze method on Actinomyces israelii ATCC 12102].	Watanabe T, Matui T, Suzuki M	Shigaku		1989
Genetics	Genome characterisation and comparative analysis of Schaalia dentiphila sp. nov. and its subspecies, S. dentiphila subsp. denticola subsp. nov., from the human oral cavity.	Tian X, Teo WFA, Yang Y, Dong L, Wong A, Chen L, Ahmed H, Choo SW, Jakubovics NS, Tan GYA.	BMC Microbiol	10.1186/s12866-024-03346-w	2024
Genetics	Noncontiguous finished genome sequences and descriptions of Actinomyces ihuae, Actinomyces bouchesdurhonensis, Actinomyces urinae, Actinomyces marseillensis, Actinomyces mediterranea and Actinomyces oralis sp. nov. identified by culturomics.	Mbogning Fonkou MD, Mailhe M, Ndongo S, Ricaboni D, Morand A, Cornu F, Tidjani Alou M, Bilen M, Andrieu C, Levasseur A, Cadoret F, Raoult D.	New Microbes New Infect	10.1016/j.nmni.2018.06.004	2018
Genetics	Genome sequence and description of Actinomyces polynesiensis str. MS2 sp. nov. isolated from the human gut.	Cimmino T, Metidji S, Labas N, Le Page S, Musso D, Raoult D, Rolain JM.	New Microbes New Infect	10.1016/j.nmni.2016.02.014	2016

References

#10954	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 43320
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#40615	; Curators of the CIP;
#46802	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 18307
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68377	Automatically annotated from API NH .
#68379	Automatically annotated from API Coryne .
#68380	Automatically annotated from API rID32A .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120287	Collection of Institut Pasteur ; Curators of the CIP; CIP 103259
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Actinomyces israelii (DSM 43320, ATCC 12102, JCM 12964)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Halophily

Murein

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

API coryne

API zym

API NH

API rID32A

Isolation, sampling and environmental information

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Genome sequences

Genome browser: GCA_000711965

16S sequences

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