Streptomyces cacaoi subsp. cacaoi (DSM 40057, ATCC 19732, ATCC 3082)

Cell morphology

Multimedia

• @ref:	9240
  multimedia content:	DSM_40057.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40057.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9240	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
9240	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)		Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM653916v1 assembly for Streptomyces cacaoi NBRC 12748	contig	GCA_006539165	66857.5		1898	37.85
67770	ASM1300445v1 assembly for Streptomyces cacaoi DSM 40057	contig	GCA_013004455	1898.4	8115138810	1898	0
67770	ASM215449v1 assembly for Streptomyces cacaoi NRRL B-1220	scaffold	GCA_002154495	1898.12	2806311026	1898	0

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Streptomyces cacaoi gene for 16S rRNA, partial sequence	AB122771	565		66857
20218	Streptomyces cacaoi gene for 16S ribosomal RNA, partial sequence, strain: JCM 4352	D44070	121		66857
20218	Streptomyces cacaoi subsp. cacaoi strain KCTC 9758 16S ribosomal RNA gene, partial sequence	AY999819	1419		66857
20218	Streptomyces cacaoi gene for 16S rRNA, partial sequence, strain: NBRC 12748	AB184115	1479		66857

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Enzymology	One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from Streptomyces cacaoi CA-170360.	Roman-Hurtado F, Sanchez-Hidalgo M, Martin J, Ortiz-Lopez FJ, Carretero-Molina D, Reyes F, Genilloud O.	Microorganisms	10.3390/microorganisms9010135	2021
	Scalp abscess due to Streptomyces cacaoi subsp. cacaoi, first report in a human infection.	Pellegrini GJ, Graziano JC, Ragunathan L, Bhat MA, Hemashettar BM, Brown JM.	J Clin Microbiol	10.1128/jcm.06372-11	2012
	The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity.	Perez-Llarena F, Martin JF, Galleni M, Coque JJ, Fuente JL, Frere JM, Liras P.	J Bacteriol	10.1128/jb.179.19.6035-6040.1997	1997
	Sequence and molecular characterization of the ROB-1 beta-lactamase gene from Pasteurella haemolytica.	Livrelli V, Peduzzi J, Joly B.	Antimicrob Agents Chemother	10.1128/aac.35.2.242	1991
Metabolism	Penicillin-binding proteins of Streptomyces cacaoi, Streptomyces olivaceus, and Streptomyces clavuligerus.	Ogawara H, Horikawa S.	Antimicrob Agents Chemother	10.1128/aac.17.1.1	1980
	Biosynthesis and Heterologous Expression of Cacaoidin, the First Member of the Lanthidin Family of RiPPs.	Roman-Hurtado F, Sanchez-Hidalgo M, Martin J, Ortiz-Lopez FJ, Genilloud O.	Antibiotics (Basel)	10.3390/antibiotics10040403	2021
Genetics	Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces.	Lee N, Hwang S, Kim J, Cho S, Palsson B, Cho BK.	Comput Struct Biotechnol J	10.1016/j.csbj.2020.06.024	2020
	Bioactive Natural Products in Actinobacteria Isolated in Rainwater From Storm Clouds Transported by Western Winds in Spain.	Sarmiento-Vizcaino A, Martin J, Reyes F, Garcia LA, Blanco G.	Front Microbiol	10.3389/fmicb.2021.773095	2021
Enzymology	Distribution of beta-lactamases in actinomycetes.	Ogawara H, Kawamura N, Kudo T, Suzuki KI, Nakase T.	Antimicrob Agents Chemother	10.1128/aac.43.12.3014	1999
	Undescribed polyether ionophores from Streptomyces cacaoi and their antibacterial and antiproliferative activities.	Gezer E, Uner G, Kucuksolak M, Kurt MU, Dogan G, Kirmizibayrak PB, Bedir E.	Phytochemistry	10.1016/j.phytochem.2021.113038	2022
Phylogeny	Endophytic actinobacteria from Mentha longifolia and Lonicera nummulariifolia: a novel source against antibiotic resistance.	Hatami H, Bahrami Y, Kakaei E.	BMC Microbiol	10.1186/s12866-025-04089-y	2025
	Pentaminomycins F and G, Nonribosomal Peptides Containing 2-Pyridylalanine.	Carretero-Molina D, Ortiz-Lopez FJ, Martin J, Gonzalez I, Sanchez-Hidalgo M, Roman-Hurtado F, Diaz C, de la Cruz M, Genilloud O, Reyes F.	J Nat Prod	10.1021/acs.jnatprod.0c01199	2021
Genetics	Metagenomics and Metagenome-Assembled Genomes: Analysis of Cupei from Sichuan Baoning Vinegar, One of the Four Traditional Renowned Vinegars in China.	Wu J, Zhao N, Li Q, Zhao K, Tu M, Li J, Hu K, Chen S, Liu S, Liu A.	Foods	10.3390/foods14030398	2025
	Chronic suppurative otitis media due to Streptomyces cacaoi, the second case report in human infection.	Ai L, Huang H, Wu Z, Liu P, Huang J, Chen Y.	BMC Infect Dis	10.1186/s12879-020-05222-0	2020
Pathogenicity	Polyethers isolated from the marine actinobacterium Streptomyces cacaoi inhibit autophagy and induce apoptosis in cancer cells.	Khan N, Yilmaz S, Aksoy S, Uzel A, Tosun C, Kirmizibayrak PB, Bedir E.	Chem Biol Interact	10.1016/j.cbi.2019.04.035	2019
	Biological efficacy of polyoxin D in crop protection.	Suda K, Kochi SI.	J Pestic Sci	10.1584/jpestics.d24-055	2025
	Nontargeted Metabolomics of Streptomyces Sourced from Thailand Reveals the Presence of Bioactive Metabolites.	Sunghanghwa Y, Paemanee A, Do KM, Meethangdee M, Plechata M, Pathom-Aree W, Punsawad C, Morita H, Tangphatsornruang S, Kamenik Z, Jaisi A.	ACS Omega	10.1021/acsomega.5c00669	2025
	Cacaoidin, First Member of the New Lanthidin RiPP Family.	Ortiz-Lopez FJ, Carretero-Molina D, Sanchez-Hidalgo M, Martin J, Gonzalez I, Roman-Hurtado F, de la Cruz M, Garcia-Fernandez S, Reyes F, Deisinger JP, Muller A, Schneider T, Genilloud O.	Angew Chem Int Ed Engl	10.1002/anie.202005187	2020
Metabolism	Ansamycins with Antiproliferative and Antineuroinflammatory Activity from Moss-Soil-Derived Streptomyces cacaoi subsp. asoensis H2S5.	Tang D, Liu LL, He QR, Yan W, Li D, Gao JM.	J Nat Prod	10.1021/acs.jnatprod.8b00203	2018
	Systematic Review of Actinomycetes in the Baijiu Fermentation Microbiome.	Chen C, Yang H, Liu J, Luo H, Zou W.	Foods	10.3390/foods11223551	2022
Metabolism	PenA, a penicillin-binding protein-type thioesterase specialized for small peptide cyclization.	Matsuda K, Fujita K, Wakimoto T.	J Ind Microbiol Biotechnol	10.1093/jimb/kuab023	2021
	Repurposing Iron- and 2-Oxoglutarate-Dependent Oxygenases to Catalyze Olefin Hydration.	Wang B, Lu Y, Cha L, Chen TY, Palacios PM, Li L, Guo Y, Chang WC, Chen C.	Angew Chem Int Ed Engl	10.1002/anie.202311099	2023
	AFB1 Microbial Degradation by Bacillus subtilis WJ6 and Its Degradation Mechanism Exploration Based on the Comparative Transcriptomics Approach.	Yang P, Wu W, Zhang D, Cao L, Cheng J.	Metabolites	10.3390/metabo13070785	2023
	Azetidine amino acid biosynthesis by non-haem iron-dependent enzymes.	Du Y, Thanapipatsiri A, Blancas Cortez JJ, Salas-Sola XE, Lin CY, Boal AK, Krebs C, Bollinger JM, Yokoyama K.	Nat Chem	10.1038/s41557-025-01958-x	2025
	Actinoquinazolinone, a New Quinazolinone Derivative from a Marine Bacterium Streptomyces sp. CNQ-617, Suppresses the Motility of Gastric Cancer Cells.	Pulat S, Kim DA, Hillman PF, Oh DC, Kim H, Nam SJ, Fenical W.	Mar Drugs	10.3390/md21090489	2023
	Challenging old microbiological treasures for natural compound biosynthesis capacity.	Nouioui I, Zimmermann A, Hennrich O, Xia S, Rossler O, Makitrynskyy R, Pablo Gomez-Escribano J, Potter G, Jando M, Doppner M, Wolf J, Neumann-Schaal M, Hughes C, Mast Y.	Front Bioeng Biotechnol	10.3389/fbioe.2024.1255151	2024
	Substrate Specificity of a Methyltransferase Involved in the Biosynthesis of the Lantibiotic Cacaoidin.	Liang H, Luo Y, van der Donk WA.	Biochemistry	10.1021/acs.biochem.4c00150	2024
	Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in Streptomyces malaysiensis F913.	Wei J, Ma M, Guo S, Xu Y, Xie J, Pan G, Zhou Z.	Antibiotics (Basel)	10.3390/antibiotics11070938	2022
Genetics	Delving into the lifestyle of Sundarban Wetland resident, biofilm producing, halotolerant Salinicoccus roseus: a comparative genomics-based intervention.	Dutta B, Halder U, Chitikineni A, Varshney RK, Bandopadhyay R.	BMC Genomics	10.1186/s12864-023-09764-w	2023
Metabolism	Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617.	Lee SE, Kim MJ, Hillman PF, Oh DC, Fenical W, Nam SJ, Lim KM.	Mar Drugs	10.3390/md20020155	2022
	Dimeric Benzodiazepines as Peptide Mimetics to Overcome p53-Dependent Drug Resistance of Tumors.	Speina E, Wilczek M, Mieczkowski A.	Biomolecules	10.3390/biom13020291	2023
	Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase.	Antypenko L, Meyer F, Sadyk Z, Shabelnyk K, Kovalenko S, Steffens KG, Garbe LA.	J Fungi (Basel)	10.3390/jof9010079	2023
Metabolism	Analysis of Volatile Molecules Present in the Secretome of the Fungal Pathogen Candida glabrata.	Lopez-Ramos JE, Bautista E, Gutierrez-Escobedo G, Mancilla-Montelongo G, Castano I, Gonzalez-Chavez MM, De Las Penas A.	Molecules	10.3390/molecules26133881	2021
Metabolism	Crystal structure of the flavin-dependent thymidylate synthase Thy1 from Thermus thermophilus with an extra C-terminal domain.	Ogawa A, Sampei GI, Kawai G.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x19007192	2019
	PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi.	Li R, Liu G, Xie Z, He X, Chen W, Deng Z, Tan H.	Mol Microbiol	10.1111/j.1365-2958.2009.06968.x	2010
Metabolism	polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis.	Li R, Xie Z, Tian Y, Yang H, Chen W, You D, Liu G, Deng Z, Tan H.	Microbiology (Reading)	10.1099/mic.0.028639-0	2009
Metabolism	Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties.	Li J, Li L, Tian Y, Niu G, Tan H.	Metab Eng	10.1016/j.ymben.2011.01.002	2011
	Mechanistic Studies on Dehydration in Class V Lanthipeptides.	Liang H, Lopez IJ, Sanchez-Hidalgo M, Genilloud O, van der Donk WA.	ACS Chem Biol	10.1021/acschembio.2c00458	2022
	Pentaminomycins C-E: Cyclic Pentapeptides as Autophagy Inducers from a Mealworm Beetle Gut Bacterium.	Hwang S, Le LTHL, Jo SI, Shin J, Lee MJ, Oh DC.	Microorganisms	10.3390/microorganisms8091390	2020
	Dual targeting of the class V lanthipeptide antibiotic cacaoidin.	Deisinger JP, Arts M, Kotsogianni I, Puls JS, Grein F, Ortiz-Lopez FJ, Martin NI, Muller A, Genilloud O, Schneider T.	iScience	10.1016/j.isci.2023.106394	2023
	Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics.	He N, Wu P, Lei Y, Xu B, Zhu X, Xu G, Gao Y, Qi J, Deng Z, Tang G, Chen W, Xiao Y.	Chem Sci	10.1039/c6sc01826b	2017
	Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase.	Budimir ZL, Patel RS, Eggly A, Evans CN, Rondon-Cordero HM, Adams JJ, Das C, Parkinson EI.	Nat Chem Biol	10.1038/s41589-023-01495-z	2024
Metabolism	Novel polyoxins generated by heterologously expressing polyoxin biosynthetic gene cluster in the sanN inactivated mutant of Streptomyces ansochromogenes.	Li J, Li L, Feng C, Chen Y, Tan H.	Microb Cell Fact	10.1186/1475-2859-11-135	2012
	Butterfly Wing Color Pattern Modification Inducers May Act on Chitin in the Apical Extracellular Site: Implications in Morphogenic Signals for Color Pattern Determination.	Otaki JM, Nakazato Y.	Biology (Basel)	10.3390/biology11111620	2022
	Non-enzymatic Transformation of Aflatoxin B1 by Pseudomonas geniculata m29.	Yao Y, Shu X, Wang D, Kan W, Su P, Hu H, Chen X, Wang D, Huang S, Wu L.	Front Microbiol	10.3389/fmicb.2021.724103	2021
	Effects of griseoviridin and viridogrisein against swine dysentery in experimental infection by using mice and pigs.	Asano T, Adachi Y.	J Vet Med Sci	10.1292/jvms.68.555	2006
Pathogenicity	Evaluation of Nematicidal Activity of Streptomyces yatensis KRA-28 against Meloidogyne incognita.	Park EJ, Jang HJ, Park CS, Lee SJ, Lee S, Kim KH, Yun BS, Lee SW, Rho MC.	J Microbiol Biotechnol	10.4014/jmb.1908.08038	2020
Biotechnology	Synthetic and Natural Antifungal Substances in Cereal Grain Protection: A Review of Bright and Dark Sides.	Szczygiel T, Kozirog A, Otlewska A.	Molecules	10.3390/molecules29163780	2024
	Co-expression of a SARP Family Activator ChlF2 and a Type II Thioesterase ChlK Led to High Production of Chlorothricin in Streptomyces antibioticus DSM 40725.	Li Y, Zhang J, Zheng J, Guan H, Liu W, Tan H.	Front Bioeng Biotechnol	10.3389/fbioe.2020.01013	2020
	Reconstitution of a mini-gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus.	Li D, Tian Y, Liu X, Wang W, Li Y, Tan H, Zhang J.	Microb Biotechnol	10.1111/1751-7915.13686	2021
	Endophytic Diaporthe as Promising Leads for the Development of Biopesticides and Biofertilizers for a Sustainable Agriculture.	Hilario S, Goncalves MFM.	Microorganisms	10.3390/microorganisms10122453	2022
Metabolism	An ATP-Dependent Ligase with Substrate Flexibility Involved in Assembly of the Peptidyl Nucleoside Antibiotic Polyoxin.	Gong R, Qi J, Wu P, Cai YS, Ma H, Liu Y, Duan H, Wang M, Deng Z, Price NPJ, Chen W.	Appl Environ Microbiol	10.1128/aem.00501-18	2018
Metabolism	Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes.	Lilla EA, Yokoyama K.	Nat Chem Biol	10.1038/nchembio.2187	2016
	The two beta-lactamase genes of Streptomyces cacaoi, blaL and blaU, are under the control of the same regulatory system.	Magdalena J, Gerard C, Joris B, Forsman M, Dusart J.	Mol Gen Genet	10.1007/s004380050488	1997
	Arbuscular mycorrhizal fungi-mediated activation of plant defense responses in direct seeded rice (Oryza sativa L.) against root-knot nematode Meloidogyne graminicola.	Malviya D, Singh P, Singh UB, Paul S, Kumar Bisen P, Rai JP, Verma RL, Fiyaz RA, Kumar A, Kumari P, Dei S, Ahmed MR, Bagyaraj DJ, Singh HV.	Front Microbiol	10.3389/fmicb.2023.1104490	2023
Genetics	Discovery of a gene cluster for the biosynthesis of novel cyclic peptide compound, KK-1, in Curvularia clavata.	Yamaguchi S, Fujioka T, Yoshimi A, Kumagai T, Umemura M, Abe K, Machida M, Kawai K.	Front Fungal Biol	10.3389/ffunb.2022.1081179	2022
	A Comparative Analysis of Microbe-Based Technologies Developed at ICAR-NBAIM Against Erysiphe necator Causing Powdery Mildew Disease in Grapes (Vitis vinifera L.).	Malviya D, Thosar R, Kokare N, Pawar S, Singh UB, Saha S, Rai JP, Singh HV, Somkuwar RG, Saxena AK.	Front Microbiol	10.3389/fmicb.2022.871901	2022
Enzymology	Aspergillus flavus Growth Inhibition and Aflatoxin B1 Decontamination by Streptomyces Isolates and Their Metabolites.	Campos-Avelar I, Colas de la Noue A, Durand N, Cazals G, Martinez V, Strub C, Fontana A, Schorr-Galindo S.	Toxins (Basel)	10.3390/toxins13050340	2021
	Two different beta-lactamase genes are present in Streptomyces cacaoi.	Magdalena J, Forsman M, Lenzini MV, Brans A, Dusart J.	FEMS Microbiol Lett	10.1016/0378-1097(92)90295-y	1992
Metabolism	Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes.	Sirand-Pugnet P, Bregeon D, Beven L, Goyenvalle C, Blanchard A, Rose S, Grosjean H, Douthwaite S, Hamdane D, Crecy-Lagard V.	Biomolecules	10.3390/biom10040587	2020
	Induction of a Streptomyces cacaoi beta-lactamase gene cloned in S. lividans.	Lenzini VM, Magdalena J, Fraipont C, Joris B, Matagne A, Dusart J.	Mol Gen Genet	10.1007/bf00286179	1992
Metabolism	Primary structure and inhibitory properties of a proteinase inhibitor produced by Streptomyces cacaoi.	Kojima S, Terabe M, Taguchi S, Momose H, Miura K.	Biochim Biophys Acta	10.1016/0167-4838(94)90060-4	1994
Metabolism	BlaB, a protein involved in the regulation of Streptomyces cacaoi beta-lactamases, is a penicillin-binding protein.	Raskin C, Gerard C, Donfut S, Giannotta E, Van Driessche G, Van Beeumen J, Dusart J.	Cell Mol Life Sci	10.1007/s00018-003-3008-9	2003
	Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H.	Chen W, Huang T, He X, Meng Q, You D, Bai L, Li J, Wu M, Li R, Xie Z, Zhou H, Zhou X, Tan H, Deng Z.	J Biol Chem	10.1074/jbc.m807534200	2009
Enzymology	Extracellular autoprocessing of a metalloprotease from Streptomyces cacaoi.	Chang PC, Lee YH.	J Biol Chem	10.1016/s0021-9258(19)50618-4	1992
	Cryptic phosphorylation in nucleoside natural product biosynthesis.	Draelos MM, Thanapipatsiri A, Sucipto H, Yokoyama K.	Nat Chem Biol	10.1038/s41589-020-00656-8	2021
	Transcriptional induction of Streptomyces cacaoi beta-lactamase by a beta-lactam compound.	Forsman M, Lindgren L, Haggstrom B, Jaurin B.	Mol Microbiol	10.1111/j.1365-2958.1989.tb00125.x	1989
	Extracellular metalloprotease gene of Streptomyces cacaoi: structure, nucleotide sequence and characterization of the cloned gene product.	Chang PC, Kuo TC, Tsugita A, Lee YH.	Gene	10.1016/0378-1119(90)90063-w	1990
Enzymology	Crystal structure of a member of a novel family of dioxygenases (PF10014) reveals a conserved cupin fold and active site.	Xu Q, Grant J, Chiu HJ, Farr CL, Jaroszewski L, Knuth MW, Miller MD, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA.	Proteins	10.1002/prot.24362	2014
	Beta-lactamase genes of Streptomyces badius, Streptomyces cacaoi and Streptomyces fradiae: cloning and expression in Streptomyces lividans.	Jaurin B, Forsman M, Haggstrom B.	Biochim Biophys Acta	10.1016/0167-4781(88)90154-6	1988
Enzymology	Cloning and amplified expression in Streptomyces lividans of the gene encoding the extracellular beta-lactamase from Streptomyces cacaoi.	Lenzini MV, Nojima S, Dusart J, Ogawara H, Dehottay P, Frere JM, Ghuysen JM.	J Gen Microbiol	10.1099/00221287-133-10-2915	1987
Enzymology	The roles of propeptide in maturation and secretion of Npr protease from Streptomyces.	Chang SC, Chang PC, Lee YH.	J Biol Chem	10.1016/s0021-9258(17)41898-9	1994
Phylogeny	Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis.	Labeda DP, Dunlap CA, Rong X, Huang Y, Doroghazi JR, Ju KS, Metcalf WW.	Antonie Van Leeuwenhoek	10.1007/s10482-016-0824-0	2017
	Antibacterial, Anticancer and Neuroprotective Activities of Rare Actinobacteria from Mangrove Forest Soils.	Azman AS, Othman I, Fang CM, Chan KG, Goh BH, Lee LH.	Indian J Microbiol	10.1007/s12088-016-0627-z	2017
Enzymology	The beta-lactamase of Streptomyces cacaoi: interaction with cefoxitin and beta-iodopenicillanate.	Lenzini MV, Frere JM.	J Enzyme Inhib	10.3109/14756368509031279	1985
	Molecular analysis of beta-lactamases from four species of Streptomyces: comparison of amino acid sequences with those of other beta-lactamases.	Forsman M, Haggstrom B, Lindgren L, Jaurin B.	J Gen Microbiol	10.1099/00221287-136-3-589	1990
	A Human Lung-Associated Streptomyces sp. TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and Modulation of Immune Response.	Herbrik A, Corretto E, Chronakova A, Langhansova H, Petraskova P, Hrdy J, Cihak M, Kristufek V, Bobek J, Petricek M, Petrickova K.	Front Microbiol	10.3389/fmicb.2019.03028	2019
	Enzyme production by genetically engineered Streptomyces strains: influence of culture conditions.	Erpicum T, Granier B, Delcour M, Lenzini VM, Nguyen-Disteche M, Dusart J, Frere JM.	Biotechnol Bioeng	10.1002/bit.260350709	1990
Metabolism	Fe(II)-dependent, uridine-5'-monophosphate alpha-ketoglutarate dioxygenases in the synthesis of 5'-modified nucleosides.	Yang Z, Unrine J, Nonaka K, Van Lanen SG.	Methods Enzymol	10.1016/b978-0-12-394291-3.00031-9	2012
Enzymology	Interaction of beta-lactamase of Streptomyces cacaoi. I. Clavulanic acid and PS-5.	Ogawara H, Mantoku A.	J Antibiot (Tokyo)	10.7164/antibiotics.34.1341	1981
Enzymology	Interaction of beta-lactamase of Streptomyces cacaoi. II. CP-45,899, izumenolide and cephamycins.	Mantoku A, Ogawara H.	J Antibiot (Tokyo)	10.7164/antibiotics.34.1347	1981
	Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review.	Mbaoji FN, Nweze JA, Yang L, Huang Y, Huang S, Onwuka AM, Peter IE, Mbaoji CC, Jiang M, Zhang Y, Pan L, Yang D.	Molecules	10.3390/molecules26195769	2021
Metabolism	Stereospecificity of the enzymatic dehydrogenation in the biosynthesis of 3-ethylidene-L-azetidine-2-carboxylic acid from isoleucine by Streptomyces cacaoi.	Hill RK, Rhee SW, Isono K, Crout DH, Suhadolnik RJ.	Biochemistry	10.1021/bi00527a041	1981
Enzymology	Regulation of the beta-lactamase BlaL of Streptomyces cacaoi: the product of the blaB regulatory gene is an internal membrane-bound protein.	Magdalena J, Joris B, Van Beeumen J, Brasseur R, Dusart J.	Biochem J	10.1042/bj3110155	1995
Pathogenicity	Penicillin-binding proteins in Streptomyces cacaoi. The effects on penicillin-binding proteins and the antibacterial activities of beta-lactams.	Ogawara H, Horikawa S.	J Antibiot (Tokyo)	10.7164/antibiotics.33.620	1980
Metabolism	Penicillin-binding proteins in Streptomyces cacaoi and Streptomyces clavuligerus. Kinetics of [13C]benzylpenicillin binding, temperature sensitivity and release of [14C]benzylpenicillin from the complex.	Horikawa S, Nakazawa H, Ogawara H.	J Antibiot (Tokyo)	10.7164/antibiotics.33.1363	1980
Enzymology	beta-lactamase from Streptomyces cacaoi. Purification and properties.	Ogawara H, Mantoku A, Shimada S.	J Biol Chem	10.1016/s0021-9258(19)69663-8	1981
	Induction of beta-lactamase and penicillin-binding proteins in Escherichia coli by introduction of Streptomyces DNA.	Nakazawa H, Nakano MM, Ogawara H.	J Antibiot (Tokyo)	10.7164/antibiotics.36.1543	1983
Metabolism	Cloning, Purification and Characterization of the Collagenase ColA Expressed by Bacillus cereus ATCC 14579.	Abfalter CM, Schonauer E, Ponnuraj K, Huemer M, Gadermaier G, Regl C, Briza P, Ferreira F, Huber CG, Brandstetter H, Posselt G, Wessler S.	PLoS One	10.1371/journal.pone.0162433	2016
	Beta-lactamase expression in Streptomyces cacaoi.	Urabe H, Lenzini MV, Mukaide M, Dusart J, Nakano MM, Ghuysen JM, Ogawara H.	J Bacteriol	10.1128/jb.172.11.6427-6434.1990	1990
Metabolism	Roles of the signal peptide and mature domains in the secretion and maturation of the neutral metalloprotease from Streptomyces cacaoi.	Chang SC, Su MH, Lee YH.	Biochem J	10.1042/bj3210029	1997
	Genetic dissection of the polyoxin building block-carbamoylpolyoxamic acid biosynthesis revealing the "pathway redundancy" in metabolic networks.	Chen W, Dai D, Wang C, Huang T, Zhai L, Deng Z.	Microb Cell Fact	10.1186/1475-2859-12-121	2013
	Studies on the ionophorous antibiotics. XI. The artifacts and the degradation products of lysocellin.	Koenuma M, Otake N.	J Antibiot (Tokyo)	10.7164/antibiotics.30.819	1977
Enzymology	The active sites of the beta-lactamases of Streptomyces cacaoi and Streptomyces albus G.	De Meester F, Joris B, Lenzini MV, Dehottay P, Erpicium T, Dusart J, Klein D, Ghuysen JM, Frere JM, Van Beeumen J.	Biochem J	10.1042/bj2440427	1987
	Nucleotide sequence and transcriptional analysis of activator-regulator proteins for beta-lactamase in Streptomyces cacaoi.	Urabe H, Ogawara H.	J Bacteriol	10.1128/jb.174.9.2834-2842.1992	1992
Pathogenicity	Expression of blaA underlies unexpected ampicillin-induced cell lysis of Shewanella oneidensis.	Yin J, Sun L, Dong Y, Chi X, Zhu W, Qi SH, Gao H.	PLoS One	10.1371/journal.pone.0060460	2013
	Interactions between active-site-serine beta-lactamases and mechanism-based inactivators: a kinetic study and an overview.	Matagne A, Ghuysen MF, Frere JM.	Biochem J	10.1042/bj2950705	1993
Enzymology	Full activation of Enterococcus faecalis gelatinase by a C-terminal proteolytic cleavage.	Del Papa MF, Hancock LE, Thomas VC, Perego M.	J Bacteriol	10.1128/jb.01311-07	2007
Enzymology	ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.	Galan JC, Reig M, Navas A, Baquero F, Blazquez J.	Antimicrob Agents Chemother	10.1128/aac.44.11.3144-3149.2000	2000
	Identification of a new DNA region specific for members of Mycobacterium tuberculosis complex.	Magdalena J, Vachee A, Supply P, Locht C.	J Clin Microbiol	10.1128/jcm.36.4.937-943.1998	1998
Metabolism	Transcriptional activation of the chlorocatechol degradative genes of Ralstonia eutropha NH9.	Ogawa N, McFall SM, Klem TJ, Miyashita K, Chakrabarty AM.	J Bacteriol	10.1128/jb.181.21.6697-6705.1999	1999
	Apis andreniformis associated Actinomycetes show antimicrobial activity against black rot pathogen (Xanthomonas campestris pv. campestris).	Promnuan Y, Promsai S, Pathom-Aree W, Meelai S	PeerJ	10.7717/peerj.12097	2021
Phylogeny	Isolation and structure determination of a new antibacterial peptide pentaminomycin C from Streptomyces cacaoi subsp. cacaoi.	Kaweewan I, Hemmi H, Komaki H, Kodani S	J Antibiot (Tokyo)	10.1038/s41429-019-0272-y	2020
Phylogeny	The search for synonyms among streptomycetes by using SDS-PAGE of whole-cell proteins. Emendation of the species Streptomyces aurantiacus, Streptomyces cacaoi subsp. cacaoi, Streptomyces caeruleus and Streptomyces violaceus.	Lanoot B, Vancanneyt M, Cleenwerck I, Wang L, Li W, Liu Z, Swings J	Int J Syst Evol Microbiol	10.1099/00207713-52-3-823	2002
Pathogenicity	Mechanisms of acquired penicillin-resistance in Streptomyces cacaoi. Role of penicillin-binding proteins in penicillin resistant mutants.	Nakazawa H, Ogawara H	J Antibiot (Tokyo)	10.7164/antibiotics.35.1683	1982
Genetics	Streptomyces phytophilus sp. nov., an endophytic actinobacterium with biosynthesis potential as an antibiotic producer.	Kaewkla O, Suriyachadkun C, Franco CMM.	Int J Syst Evol Microbiol	10.1099/ijsem.0.005834	2023
	Streptomyces coriariae sp. nov., a novel streptomycete isolated from actinorhizal nodules of Coriaria intermedia.	Berckx F, Bandong CM, Wibberg D, Kalinowski J, Willemse J, Brachmann A, Simbahan J, Pawlowski K.	Int J Syst Evol Microbiol	10.1099/ijsem.0.005603	2022
Phylogeny	Reclassification of four subspecies in the genus Streptomyces to Streptomyces rubradiris sp. nov., Streptomyces asoensis sp. nov., Streptomyces fructofermentans sp. nov. and Streptomyces ossamyceticus sp. nov.	Komaki H, Tamura T.	Int J Syst Evol Microbiol	10.1099/ijsem.0.005078	2021
Phylogeny	Identification of four novel Streptomyces isolated from machair grassland soil using a culture-based bioprospecting strategy: Streptomyces caledonius sp. nov., Streptomyces machairae sp. nov., Streptomyces pratisoli sp. nov. and Streptomyces achmelvichensis sp. nov.	Prole JR, Allenby N, Manning DAC, Goodfellow M.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006736	2025
Phylogeny	Streptomyces iconiensis sp. nov. and Streptomyces smyrnaeus sp. nov., two halotolerant actinomycetes isolated from a salt lake and saltern.	Tatar D, Guven K, Sproer C, Klenk HP, Sahin N	Int J Syst Evol Microbiol	10.1099/ijs.0.062216-0	2014
Phylogeny	Streptomyces nanshensis sp. nov., isolated from the Nansha Islands in the South China Sea.	Tian XP, Zhang YQ, Li QX, Zhi XY, Tang SK, Zhang S, Li WJ	Int J Syst Evol Microbiol	10.1099/ijs.0.003442-0	2009
Phylogeny	Streptomyces specialis sp. nov.	Kampfer P, Huber B, Buczolits S, Thummes K, Grun-Wollny I, Busse HJ	Int J Syst Evol Microbiol	10.1099/ijs.0.2008/001008-0	2008