Streptomyces atroolivaceus (DSM 40137, ATCC 19725, CBS 464.68)

Name: Streptomyces atroolivaceus (DSM 40137, ATCC 19725, CBS 464.68)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 15005

Type strain

Culture col. no. DSM 40137 ATCC 19725 CBS 464.68 IFO 12741 INA 4776/54 17 more

NCBI tax ID(s) 66869

Special Collections DSMZ CCUG JCM CIP Wink compendium

History <- E.B. Shirling, ISP <- T.P. Preobrazhenskaya, INA KCC S-0345 <-- IFO 12741 <-- SAJ <-- ISP 5137 <-- INA 4776. CIP <- 2004, CCUG <- 1981, M. Ridell, Göteborg Univ., Göteborg, Sweden <- S.T. Williams

Links

Streptomyces atroolivaceus DSM 40137 is an obligate aerobe, mesophilic, Gram-positive prokaryote that was isolated from soil.

Gram-positive rod-shaped obligate aerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 13329

LMG 19306,ATCC 19725,CCRC 12073,CCUG 11112,DSM 40137,IFO 12741,IMET 43088,JCM 4345,VKM Ac-970,CBS 464.68,AS 4.1405,CECT 3316,KCTC 9017,NBRC 12741,NRRL ISP-5137,BCRC 12073,CIP 108257,CGMCC 4.1405,VTT E-052933

@ref 20215

Last LPSN update 2026-02-09 11:21:34

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Kitasatosporales

Family Streptomycetaceae

Genus Streptomyces

Species Streptomyces atroolivaceus

Full scientific name Streptomyces atroolivaceus (Preobrazhenskaya et al. 1957) Pridham et al. 1958 (Approved Lists 1980)

Synonyms (3)

"Actinomyces atroolivaceus"
Streptomyces olivoviridis
"Actinomyces olivoviridis"

BacDive ID	Other strains from **Streptomyces atroolivaceus** (4)	Type strain
15006	S. atroolivaceus DSM 40211, ATCC 15882, ATCC 23944, CBS 928.68, ...
15007	S. atroolivaceus DSM 46459, IMET 41324
128378	S. atroolivaceus STI10636(IMET), NCTC 7238
160204	S. atroolivaceus BCRU MITI 12, DSM 42161

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
116541	positive	rod-shaped
125438	positive			91.363

Colony morphology

116541

Hemolysis ability1

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
9339	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)	Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
36711	MEDIUM 57 - for Streptomyces, Nocardioides, Lentzea albidocapillata and Streptoverticillium reticulum		Distilled water make up to (1000.000 ml);Agar (15.000 g);Glucose (4.000g);Yeast extract (4.000 g);Malt extract (10.000 g);Calcium carbonate (2.000 g)
116541	CIP Medium 57	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
9339	positive	growth	28	mesophilic
18542	positive	optimum	28	mesophilic
36711	positive	growth	25	mesophilic
67770	positive	growth	28	mesophilic
116541	positive	growth	10-37
116541	negative	growth	41
116541	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
116541	obligate aerobe
125438	aerobe	91.888

Spore formation

@ref	Spore formation	Confidence
125438		93.468

Halophily

@ref	Salt	Growth	Tested relation	Concentration
116541	NaCl	positive	growth	0-6 %
116541	NaCl		growth	8 %
116541	NaCl		growth	10 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
18542	22599 ChEBI	arabinose	+/-
68368	29016 ChEBI	arginine	+	hydrolysis	from API 20E
18542	62968 ChEBI	cellulose	-
116541	16947 ChEBI	citrate	-	carbon source
68368	16947 ChEBI	citrate	+	assimilation	from API 20E
116541	4853 ChEBI	esculin	+	hydrolysis
18542	28757 ChEBI	fructose	-
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
18542	17234 ChEBI	glucose	+
116541	606565 ChEBI	hippurate	+	hydrolysis
68368	25094 ChEBI	lysine	+	degradation	from API 20E
18542	29864 ChEBI	mannitol	-
18542	17268 ChEBI	myo-inositol	-
116541	17632 ChEBI	nitrate	-	reduction
116541	17632 ChEBI	nitrate	-	respiration
116541	16301 ChEBI	nitrite	-	reduction
68368	18257 ChEBI	ornithine	+	degradation	from API 20E
18542	16634 ChEBI	raffinose	-
18542	26546 ChEBI	rhamnose	+
18542	17992 ChEBI	sucrose	-
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	+	hydrolysis	from API 20E
18542	18222 ChEBI	xylose	-

Antibiotic resistance

@ref	Metabolite	Is sensitive	Is resistant
116541	0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)

Metabolite production

@ref	Chebi-ID	Metabolite
68368	15688 ChEBI	acetoin	from API 20E
68368	16136 ChEBI	hydrogen sulfide	from API 20E
116541	35581 ChEBI	indole
68368	35581 ChEBI	indole	from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test	Indole test
116541	15688 ChEBI	acetoin	-
68368	15688 ChEBI	acetoin	+			from API 20E
116541	17234 ChEBI	glucose		-
68368	35581 ChEBI	indole			-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
116541	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
116541	amylase	+
68368	arginine dihydrolase	+	3.5.3.6	from API 20E
68382	beta-galactosidase	+	3.2.1.23	from API zym
116541	beta-galactosidase	+	3.2.1.23
68368	beta-galactosidase	+	3.2.1.23	from API 20E
68382	beta-glucosidase	+	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
116541	caseinase	-	3.4.21.50
116541	catalase	+	1.11.1.6
68382	cystine arylamidase	+	3.4.11.3	from API zym
116541	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
116541	gamma-glutamyltransferase	+	2.3.2.2
116541	gelatinase	+/-
68368	gelatinase	+		from API 20E
116541	lecithinase	+
68382	leucine arylamidase	+	3.4.11.1	from API zym
116541	lipase	-
68382	lipase (C 14)	+		from API zym
116541	lysine decarboxylase	-	4.1.1.18
68368	lysine decarboxylase	+	4.1.1.18	from API 20E
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
116541	ornithine decarboxylase	-	4.1.1.17
68368	ornithine decarboxylase	+	4.1.1.17	from API 20E
116541	oxidase	-
116541	phenylalanine ammonia-lyase	-	4.3.1.24
68382	trypsin	+	3.4.21.4	from API zym
116541	tryptophan deaminase	-
68368	tryptophan deaminase	+	4.1.99.1	from API 20E
116541	tween esterase	+
116541	urease	+	3.5.1.5
68368	urease	+	3.5.1.5	from API 20E
68382	valine arylamidase	+		from API zym

API 20E

@ref	ONPG	ADH (Arg)	LDC (Lys)	ODC	CIT	H2S productionH2S	URE	TDA (Trp)	IND	Acetoin production (Voges Proskauer test)VP	GEL	GLU	MAN	INO	Sor	RHA	SAC	MEL	AMY	ARA	OX	Nitrite productionNO2	Reduction to N2N2	MotilityMOB	Growth on MacConkey mediumMAC	OF-O	OF-F
18542	+	+	+	+	+	-	+	+	-	+	+	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
116541	-	+	+	+	+	+	+	+	+	-	+	+	-	+	-	+	+	-	-	-

API biotype100

@ref	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
116541	not determinedn.d.	+	+	+	+	+	-	-	-	-	+	+	+	+	-	-	+	+	-	+	+	+	-	-	+	+	-	-	-	-	-	-	+	-	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	+	+	-	+	+	-	+	-	-	-	-	-	+	+	-	+	+	-	-	-	+	+	-	-	-	-	-	-	-	-	+	+	-	-	-	-	-	+	+	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Soil

Isolation

@ref	Sample type	Country	Continent
9339	soil	USSR	Asia
67770	Soil

Taxonmaps

69479

Global distribution of 16S sequence AJ781320 (>99% sequence identity) for Streptomyces from Microbeatlas

Aquatic Samples	286
Soil Samples	2441
Animal Samples	1009
Plant Samples	294
Total Samples	4030

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
9339	1	Risk group (German classification) According to TRBA 466
18542	1	German classification According to TRBA 466
116541	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
124043	ASM4265220v1 assembly for Streptomyces atroolivaceus CGMCC 4.1405	scaffold	GCA_042652205			66869	69.21
124043	ASM4266190v1 assembly for Streptomyces atroolivaceus CCUG 11112	scaffold	GCA_042661905			66869	67.63
67770	ASM71702v1 assembly for Streptomyces atroolivaceus NRRL ISP-5137	contig	GCA_000717025	66869.3	2772190708	66869	58.56

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptomyces atroolivaceus gene for 16S ribosomal RNA, partial sequence, strain: JCM 4345	D44064	120	66869
20218	Streptomyces atroolivaceus strain KCTC 9017 16S ribosomal RNA gene, partial sequence	AY999832	1420	66869
20218	Streptomyces atroolivaceus 16S rRNA gene, type strain LMG 19306	AJ781320	1478	66869
20218	Streptomyces atroolivaceus gene for 16S rRNA, partial sequence, strain: NBRC 12741	AB184113	1473	66869

GC content

@ref	GC-content (mol%)	Method
67770	70.7	genome sequence analysis

Genome-based predictions

Predictions

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptomyces atroolivaceus NRRL ISP-5137
NCBI: GCA_000717025.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	91.36	no
125438	anaerobic	anaerobicⓘ	no	97.89	yes
125438	aerobic	aerobicⓘ	yes	91.89	yes
125438	spore-forming	spore-formingⓘ	yes	93.47	no
125438	thermophilic	thermophileⓘ	no	96.50	no
125438	flagellated	motile2+ⓘ	no	88.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74.	Arnal G, Stogios PJ, Asohan J, Attia MA, Skarina T, Viborg AH, Henrissat B, Savchenko A, Brumer H.	J Biol Chem	10.1074/jbc.ra119.009861	2019
	An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived Streptomyces sp. CPCC 203702.	Guo Z, Zhang D, Wang Y, Bai J, Hu J, Cen S, Yu L.	RSC Adv	10.1039/d4ra01496k	2024
Genetics	Genome Mining of Streptomyces sp. YIM 130001 Isolated From Lichen Affords New Thiopeptide Antibiotic.	Schneider O, Simic N, Aachmann FL, Ruckert C, Kristiansen KA, Kalinowski J, Jiang Y, Wang L, Jiang CL, Lale R, Zotchev SB.	Front Microbiol	10.3389/fmicb.2018.03139	2018
Phylogeny	Diversity of Culturable Bacteria Isolated from Highland Barley Cultivation Soil in Qamdo, Tibet Autonomous Region.	Pan HU, Zhou J, Dawa Z, Dai Y, Zhang Y, Yang H, Wang C, Liu H, Zhou H, Lu X, Tian Y.	Pol J Microbiol	10.33073/pjm-2021-008	2021
	Genomes of four Streptomyces strains reveal insights into putative new species and pathogenicity of scab-causing organisms.	Henao L, Zade RSH, Restrepo S, Husserl J, Abeel T.	BMC Genomics	10.1186/s12864-023-09190-y	2023
Phylogeny	Comprehensive investigation of marine Actinobacteria associated with the sponge Halichondria panicea.	Schneemann I, Nagel K, Kajahn I, Labes A, Wiese J, Imhoff JF.	Appl Environ Microbiol	10.1128/aem.00780-10	2010
Phylogeny	Endophytic actinobacteria from Mentha longifolia and Lonicera nummulariifolia: a novel source against antibiotic resistance.	Hatami H, Bahrami Y, Kakaei E.	BMC Microbiol	10.1186/s12866-025-04089-y	2025
	A comprehensive analysis of human gut microbial biosynthesis gene clusters unveiling the dominant role of Paenibacillus.	Gao H, Zhuang D, Zhou H, Su Q, Hu X, Wang Y, Bao W, Zhu L.	mSystems	10.1128/msystems.00610-25	2025
Metabolism	The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2R)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis.	Lohman JR, Shen B.	Biochemistry	10.1021/acs.biochem.0c00749	2020
Metabolism	Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.	Huang Y, Yang D, Pan G, Tang GL, Shen B.	Appl Microbiol Biotechnol	10.1007/s00253-016-7864-2	2016
Metabolism	P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.	Kwong T, Ma M, Pan G, Hindra, Yang D, Yang C, Lohman JR, Rudolf JD, Cleveland JL, Shen B.	Biochemistry	10.1021/acs.biochem.8b00623	2018
	Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.	Liu T, Ma M, Ge HM, Yang C, Cleveland J, Shen B.	Bioorg Med Chem Lett	10.1016/j.bmcl.2015.05.078	2015
Metabolism	Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine.	Tang GL, Cheng YQ, Shen B.	J Biol Chem	10.1074/jbc.m702814200	2007
Metabolism	Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species.	Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B.	Proc Natl Acad Sci U S A	10.1073/pnas.1506761112	2015
Phylogeny	Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA-DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species.	Rong X, Huang Y.	Int J Syst Evol Microbiol	10.1099/ijs.0.012419-0	2010
Metabolism	C-S bond cleavage by a polyketide synthase domain.	Ma M, Lohman JR, Liu T, Shen B.	Proc Natl Acad Sci U S A	10.1073/pnas.1508437112	2015
Enzymology	The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster.	Zhou W, Liang H, Qin X, Cao D, Zhu X, Ju J, Shen B, Duan Y, Huang Y.	J Nat Prod	10.1021/acs.jnatprod.9b00321	2020
Metabolism	Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.	Tang GL, Cheng YQ, Shen B.	Chem Biol	10.1016/j.chembiol.2003.12.014	2004
	Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy.	Aboelella NS, Brandle C, Kim T, Ding ZC, Zhou G.	Cancers (Basel)	10.3390/cancers13050986	2021
Metabolism	Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase.	Meng S, Steele AD, Yan W, Pan G, Kalkreuter E, Liu YC, Xu Z, Shen B.	Nat Commun	10.1038/s41467-021-25798-8	2021
Metabolism	Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.	Tang GL, Cheng YQ, Shen B.	J Nat Prod	10.1021/np050467t	2006
Phylogeny	Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis.	Labeda DP, Dunlap CA, Rong X, Huang Y, Doroghazi JR, Ju KS, Metcalf WW.	Antonie Van Leeuwenhoek	10.1007/s10482-016-0824-0	2017
Metabolism	Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis.	Suroto DA, Kitani S, Arai M, Ikeda H, Nihira T.	PLoS One	10.1371/journal.pone.0190973	2018
Metabolism	Type I polyketide synthases that require discrete acyltransferases.	Cheng YQ, Coughlin JM, Lim SK, Shen B.	Methods Enzymol	10.1016/s0076-6879(09)04608-4	2009
	Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.	Cheng YQ, Tang GL, Shen B.	J Bacteriol	10.1128/jb.184.24.7013-7024.2002	2002
Metabolism	Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis.	Cheng YQ, Tang GL, Shen B.	Proc Natl Acad Sci U S A	10.1073/pnas.0537286100	2003
Metabolism	The study of variability and strain selection in Streptomyces atroolivaceus. III. Isolation and preliminary characteristics of mutants impaired in the biosynthesis of mithramycin.	Blumauerova M, Lipavska H, Stajner K, Vanek Z.	Folia Microbiol (Praha)	10.1007/bf02876904	1976
Metabolism	Decoding and reprogramming fungal iterative nonribosomal peptide synthetases.	Yu D, Xu F, Zhang S, Zhan J.	Nat Commun	10.1038/ncomms15349	2017
	Recent synthesis of thietanes.	Xu J.	Beilstein J Org Chem	10.3762/bjoc.16.116	2020
Enzymology	Type I pyridoxal 5'-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly lines.	Milano T, Paiardini A, Grgurina I, Pascarella S.	BMC Struct Biol	10.1186/1472-6807-13-26	2013
Metabolism	Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthase.	Wesener SR, Potharla VY, Cheng YQ.	Appl Environ Microbiol	10.1128/aem.01513-10	2011
Metabolism	Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.	Zhao C, Ju J, Christenson SD, Smith WC, Song D, Zhou X, Shen B, Deng Z.	J Bacteriol	10.1128/jb.00173-06	2006
Enzymology	Polyketide synthase gene responsible for citrinin biosynthesis in Monascus purpureus.	Shimizu T, Kinoshita H, Ishihara S, Sakai K, Nagai S, Nihira T.	Appl Environ Microbiol	10.1128/aem.71.7.3453-3457.2005	2005
Metabolism	Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449.	Jorgensen H, Degnes KF, Dikiy A, Fjaervik E, Klinkenberg G, Zotchev SB.	Appl Environ Microbiol	10.1128/aem.00744-09	2010
Metabolism	Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein.	Rawat M, Uppal M, Newton G, Steffek M, Fahey RC, Av-Gay Y.	J Bacteriol	10.1128/jb.186.18.6050-6058.2004	2004
	Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42.	Chen XH, Vater J, Piel J, Franke P, Scholz R, Schneider K, Koumoutsi A, Hitzeroth G, Grammel N, Strittmatter AW, Gottschalk G, Sussmuth RD, Borriss R.	J Bacteriol	10.1128/jb.00052-06	2006
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Metabolism	Biosynthetic Genes for the Tetrodecamycin Antibiotics.	Gverzdys T, Nodwell JR	J Bacteriol	10.1128/JB.00140-16	2016
Phylogeny	Streptomyces castrisilvae sp. nov. and Streptomyces glycanivorans sp. nov., novel soil streptomycetes metabolizing mutan and alternan.	Widen T, Rangel AT, Lombard V, Drula E, Mazurkewich S, Terrapon N, Kerkhoven EJ, Larsbrink J.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006514	2024
Genetics	Genome insights into the pharmaceutical and plant growth promoting features of the novel species Nocardia alni sp. nov.	Nouioui I, Ha SM, Baek I, Chun J, Goodfellow M.	BMC Genomics	10.1186/s12864-021-08257-y	2022
Phylogeny	Streptomyces silvae sp. nov., isolated from forest soil.	Besaury L, Martinet L, Muhle E, Clermont D, Remond C	Int J Syst Evol Microbiol	10.1099/ijsem.0.005147	2021

References

#9339	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40137
#18542	Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#36711	; Curators of the CIP;
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68368	Automatically annotated from API 20E .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#116541	Collection of Institut Pasteur ; Curators of the CIP; CIP 108257
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptomyces atroolivaceus (DSM 40137, ATCC 19725, CBS 464.68)

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