Streptomyces althioticus (DSM 40092, ATCC 19724, CBS 463.68)

Name: Streptomyces althioticus (DSM 40092, ATCC 19724, CBS 463.68)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 14970

Type strain

Strain Designation 245-22

Culture col. no. DSM 40092 ATCC 19724 CBS 463.68 IFO 12740 ISP 5092 11 more

NCBI tax ID(s) 83380

Special Collections DSMZ JCM KCTC Wink compendium

History DSMZ <- E.B. Shirling, ISP <- B. Yamaguchi, 245-22 JCM <-- KCC S-0344 <-- IFO 12740 <-- SAJ <-- ISP 5092 <-- T. Yamaguchi 254-Z2.

Links

Streptomyces althioticus 245-22 is a bacterium that builds an aerial mycelium and produces antibiotic compounds.

antibiotic compound production genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 92862

ATCC 19724,IFO 12740,IFO 15956,DSM 40092,JCM 4344,CCRC 13686,NRRL B-3981,VKM Ac-705,CBS 463.68,KCTC 9752,AS 4.1608,NBRC 12740,NBRC 15956,BCRC 13686,NRRL 3981,CGMCC 4.1608

@ref 20215

Last LPSN update 2026-05-29 08:28:25

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Kitasatosporales

Family Streptomycetaceae

Genus Streptomyces

Species Streptomyces althioticus

Full scientific name Streptomyces althioticus Yamaguchi et al. 1957 (Approved Lists 1980)

Synonyms (3)

Streptomyces matensis
Streptomyces griseorubens
"Actinomyces griseorubens"

Morphology

Cell morphology

@ref	Confidence	Gram stain
125439	93.567
125439	99.122	positive
125438	90.456	positive

Colony morphology

@ref	Colony color	Incubation period	Medium used
19401	Terra brown	10-14 days	ISP 2
19401	Terra brown	10-14 days	ISP 3
19401	Brown beige	10-14 days	ISP 4
19401	Brown beige	10-14 days	ISP 5
19401	Beige	10-14 days	ISP 6
19401	Ochre brown	10-14 days	ISP 7

Multicellular morphology

@ref	Complex name	Complex color	Medium name
19401	Aerial Mycelium	Light grey	ISP 2
19401	Aerial Mycelium	Light grey	ISP 3
19401	Aerial Mycelium	Cream	ISP 4
19401			ISP 5
19401			ISP 6
19401			ISP 7

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
9304	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)	Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
19401	ISP 2		Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
19401	ISP 3		Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
19401	ISP 4		Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
19401	ISP 5		Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
19401	ISP 6		Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
19401	ISP 7		Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes
9304	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)	Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
9304	positive	growth	28
19401	positive	optimum	28
67770	positive	growth	28

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125438	aerobe	91.439
125439	obligate aerobe	99.071

Spore formation

@ref	Spore formation	Confidence
125439		90.707
125438		93.303

Compound production

@ref	Compound
9304	althiomycin
9304	matamycin

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
19401	22599 ChEBI	arabinose	+
68368	29016 ChEBI	arginine	+	hydrolysis	from API 20E
19401	62968 ChEBI	cellulose	+
68368	16947 ChEBI	citrate	+	assimilation	from API 20E
19401	28757 ChEBI	fructose	+
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
19401	17234 ChEBI	glucose	+
68368	25094 ChEBI	lysine	+	degradation	from API 20E
19401	29864 ChEBI	mannitol	+
19401	17268 ChEBI	myo-inositol	+
68368	18257 ChEBI	ornithine	+	degradation	from API 20E
19401	16634 ChEBI	raffinose	-
19401	26546 ChEBI	rhamnose	+
19401	17992 ChEBI	sucrose	-
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	+	hydrolysis	from API 20E
19401	18222 ChEBI	xylose	-

Metabolite production

@ref	Chebi-ID	Metabolite
68368	15688 ChEBI	acetoin	from API 20E
68368	16136 ChEBI	hydrogen sulfide	from API 20E
68368	35581 ChEBI	indole	from API 20E
67770		matamycin

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	-		from API 20E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	+	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	+	3.2.1.24	from API zym
68368	arginine dihydrolase	+	3.5.3.6	from API 20E
68382	beta-galactosidase	+	3.2.1.23	from API zym
68368	beta-galactosidase	+	3.2.1.23	from API 20E
68382	beta-glucosidase	+	3.2.1.21	from API zym
68382	beta-glucuronidase	+	3.2.1.31	from API zym
68382	cystine arylamidase	+	3.4.11.3	from API zym
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
68368	gelatinase	+		from API 20E
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	+		from API zym
68368	lysine decarboxylase	+	4.1.1.18	from API 20E
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
68368	ornithine decarboxylase	+	4.1.1.17	from API 20E
68382	trypsin	+	3.4.21.4	from API zym
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68368	urease	+	3.5.1.5	from API 20E
68382	valine arylamidase	+		from API zym

API 20E

@ref	ONPG	ADH (Arg)	LDC (Lys)	ODC	CIT	H2S productionH2S	URE	TDA (Trp)	IND	Acetoin production (Voges Proskauer test)VP	GEL	GLU	MAN	INO	Sor	RHA	SAC	MEL	AMY	ARA	OX	Nitrite productionNO2	Reduction to N2N2	MotilityMOB	Growth on MacConkey mediumMAC	OF-O	OF-F
19401	+	+	+	+	+	-	+	-	-	-	+	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
19401	not determinedn.d.	+	+	+	+	+	+	+	+	-	+	+	+	+	+	+	+	+	+	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Soil

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
9304	soil		Japan	JPN	Asia
67770	Soil	Yachigusa, Kanzaki, Hyogo Pref.	Japan	JPN	Asia

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
9304	1	Risk group (German classification) According to TRBA 466
19401	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM1464935v1 assembly for Streptomyces althioticus JCM 4344	scaffold	GCA_014649355	83380.3	8109823374	83380	40.8

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptomyces althioticus gene for 16S rRNA, partial sequence	AB018205	121	83380
20218	Streptomyces althioticus strain KCTC 9752 16S ribosomal RNA gene, partial sequence	AY999808	1421	83380
20218	Streptomyces althioticus gene for 16S rRNA, partial sequence, strain: NBRC 12740	AB184112	1465	83380
20218	Streptomyces althioticus strain NRRL B-3981 16S ribosomal RNA gene, partial sequence	AY999791	1494	83380
124043	Streptomyces althioticus strain JCM 4344 16S ribosomal RNA gene, partial sequence.	MT760514	1223	83380

GC content

@ref	GC-content (mol%)	Method
67770	72.5	genome sequence analysis

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM1464935v1 assembly for Streptomyces althioticus JCM 4344
BV-BRC: 83380.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.07	no
125439	gram_stain	BacteriaNetⓘ	positive	99.12	no
125439	motility	BacteriaNetⓘ	no	93.57	no
125439	spore_formation	BacteriaNetⓘ	yes	90.71	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptomyces althioticus strain JCM 4344
PATRIC: 83380.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	90.46	no
125438	anaerobic	anaerobicⓘ	no	97.40	no
125438	aerobic	aerobicⓘ	yes	91.44	no
125438	spore-forming	spore-formingⓘ	yes	93.30	no
125438	thermophilic	thermophileⓘ	no	97.00	yes
125438	flagellated	motile2+ⓘ	no	89.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Validation List no. 224. Valid publication of new names and new combinations effectively published outside the IJSEM.	Oren A, Goker M.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006801	2025
Metabolism	Bioproduction, characterization, anticancer and antioxidant activities of extracellular melanin pigment produced by newly isolated microbial cell factories Streptomyces glaucescens NEAE-H.	El-Naggar NE, El-Ewasy SM.	Sci Rep	10.1038/srep42129	2017
Pathogenicity	Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.	Brana AF, Sarmiento-Vizcaino A, Perez-Victoria I, Martin J, Otero L, Palacios-Gutierrez JJ, Fernandez J, Mohamedi Y, Fontanil T, Salmon M, Cal S, Reyes F, Garcia LA, Blanco G.	Mar Drugs	10.3390/md17020114	2019
Phylogeny	Reclassification of 15 Streptomyces species as synonyms of Streptomyces albogriseolus, Streptomyces althioticus, Streptomyces anthocyanicus, Streptomyces calvus, Streptomyces griseoincarnatus, Streptomyces mutabilis, Streptomyces pilosus or Streptomyces rochei.	Komaki H.	Int J Syst Evol Microbiol	10.1099/ijsem.0.004718	2019
	Cultivation and sequencing of microbiota members unveil the functional potential of yak gut microbiota.	Dai M, Zhao F, Shi X, Tian C, Lin Y, Bai L, Li T, Jin X, Xiao L, Kristiansen K, Li X, Zhang Z.	mSystems	10.1128/msystems.00367-25	2025
	Characterization and evaluation of actinomycete from the Protaetia brevitarsis Larva Frass.	Zhang L, Zhao T, Geng L, Zhang C, Xiang W, Zhang J, Wang X, Shu C.	Front Microbiol	10.3389/fmicb.2024.1385734	2024
	Biotechnological and pharmaceutical potential of twenty-eight novel type strains of Actinomycetes from different environments worldwide.	Nouioui I, Boldt J, Zimmermann A, Makitrynskyy R, Potter G, Jando M, Doppner M, Kirstein S, Neumann-Schaal M, Gomez-Escribano JP, Nubel U, Mast Y.	Curr Res Microb Sci	10.1016/j.crmicr.2024.100290	2024
Phylogeny	Taxonomic and Metabolite Diversities of Moss-Associated Actinobacteria from Thailand.	Insuk C, Pongpamorn P, Forsythe A, Matsumoto A, Omura S, Pathom-Aree W, Cheeptham N, Xu J.	Metabolites	10.3390/metabo12010022	2021
	Rational design and synthesis of new pyrrolone candidates as prospective insecticidal agents against Culex pipiens L. Larvae.	Hekal MH, Hashem AI, El-Azm FSMA, Abdel-Haleem DR, Rafat EH, Ali YM.	Sci Rep	10.1038/s41598-024-74011-5	2024
	Actinoflavosides B-D, Flavonoid Type Glycosides from Tidal Mudflat-Derived Actinomyces.	Jeong H, Jo SJ, Bae M, Kim YR, Moon K.	Mar Drugs	10.3390/md20090565	2022
	Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia.	Liu SW, Jadambaa N, Nikandrova AA, Osterman IA, Sun CH.	Microorganisms	10.3390/microorganisms10050989	2022
	Diversity and Biocontrol Potential of Cultivable Endophytic Bacteria Associated with Halophytes from the West Aral Sea Basin.	Gao L, Ma J, Liu Y, Huang Y, Mohamad OAA, Jiang H, Egamberdieva D, Li W, Li L.	Microorganisms	10.3390/microorganisms9071448	2021
	Streptomyces polyketides mediate bacteria-fungi interactions across soil environments.	Krespach MKC, Stroe MC, Netzker T, Rosin M, Zehner LM, Komor AJ, Beilmann JM, Kruger T, Scherlach K, Kniemeyer O, Schroeckh V, Hertweck C, Brakhage AA.	Nat Microbiol	10.1038/s41564-023-01382-2	2023
Metabolism	Improvement of bread making quality by supplementation with a recombinant xylanase produced by Pichia pastoris.	de Queiroz Brito Cunha CC, Gama AR, Cintra LC, Bataus LAM, Ulhoa CJ.	PLoS One	10.1371/journal.pone.0192996	2018
Genetics	Antibiotics from predatory bacteria.	Korp J, Vela Gurovic MS, Nett M.	Beilstein J Org Chem	10.3762/bjoc.12.58	2016
Pathogenicity	Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus.	Haste NM, Thienphrapa W, Tran DN, Loesgen S, Sun P, Nam SJ, Jensen PR, Fenical W, Sakoulas G, Nizet V, Hensler ME.	J Antibiot (Tokyo)	10.1038/ja.2012.77	2012
Metabolism	The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin.	Gerc AJ, Song L, Challis GL, Stanley-Wall NR, Coulthurst SJ.	PLoS One	10.1371/journal.pone.0044673	2012
Phylogeny	Characterization and phylogenetic analysis of antituberculous compound producing actinomycete strain D25 isolated from Thar Desert soil, Rajasthan.	Radhakrishnan M, Gopikrishnan V, Suresh A, Selvakumar N, Balagurunathan R, Kumar V	Bioinformation	10.6026/97320630009018	2013
Phylogeny	Streptomyces lichenis sp. nov., isolated from lichen.	Saeng-In P, Phongsopitanun W, Savarajara A, Tanasupawat S	Int J Syst Evol Microbiol	10.1099/ijsem.0.003052	2018
Phylogeny	Streptomyces fuscigenes sp. nov., isolated from bamboo (Sasa borealis) litter.	Lee HJ, Whang KS	Int J Syst Evol Microbiol	10.1099/ijsem.0.002706	2018
Phylogeny	Streptomyces wuyuanensis sp. nov., an actinomycete from soil.	Zhang X, Zhang J, Zheng J, Xin D, Xin Y, Pang H	Int J Syst Evol Microbiol	10.1099/ijs.0.047050-0	2013

References

#9304	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 40092
#19401	Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68368	Automatically annotated from API 20E .
#68382	Automatically annotated from API zym .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptomyces althioticus (DSM 40092, ATCC 19724, CBS 463.68)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Multicellular morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Compound production

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

API 20E

API zym

Isolation, sampling and environmental information

Isolation source categories

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_014649355

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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