Clostridioides difficile (CCUG 37780, ATCC 43593)

Name: Clostridioides difficile (CCUG 37780, ATCC 43593)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 149458

Type strain

Culture col. no. CCUG 37780 ATCC 43593

NCBI tax ID(s) 1496

Special Collections CCUG

Links

Clostridioides difficile CCUG 37780 is an anaerobe, mesophilic prokaryote of the family Peptostreptococcaceae.

anaerobe mesophilic

Name and taxonomic classification

SI-ID 41928

ATCC 43593,CCUG 37780,ACM 5047

@ref 20215

Last LPSN update 2025-12-16 10:05:52

Domain Bacillati

Phylum Bacillota

Class Clostridia

Order Peptostreptococcales

Family Peptostreptococcaceae

Genus Clostridioides

Species Clostridioides difficile

Full scientific name Clostridioides difficile (Hall and O'Toole 1935) Lawson et al. 2016

Synonyms (3)

"Peptoclostridium difficile"
"Bacillus difficilis"
Clostridium difficile

BacDive ID	Other strains from **Clostridioides difficile** (81)	Type strain
2582	C. difficile 1780, McClung 1780, 90556-M6S, 10008, DSM ... (type strain)
2583	C. difficile AA1, DSM 12056
2584	C. difficile A90, DSM 12057
22963	C. difficile R20291, DSM 27147, NCTC 13366
23853	C. difficile 630, DSM 27543, ATCC BAA-1382, NCTC 13307
23854	C. difficile 1470, DSM 27544, ATCC 43598, NCTC 13569, ...
23855	C. difficile 630 Delta erm, DSM 28645
134676	C. difficile CD196, CIP 107932
134703	C. difficile CIP 109239
135237	C. difficile W 1194, CIP 104903, ATCC 43594, CCUG 37779
135760	C. difficile CIP 110322
137137	C. difficile CIP 109238
137139	C. difficile CIP 109240, ATCC 43255, CCUG 19126, VPI 10463
138126	C. difficile 2149, CIP 104905, ATCC 43600, CCUG 37784
138128	C. difficile 545, CIP 104904, ATCC 43596, CCUG 37766
141963	C. difficile CCUG 8884
141965	C. difficile CCUG 9004
141966	C. difficile CCUG 9018
143578	C. difficile CCUG 20309
143948	C. difficile CCUG 22019
143949	C. difficile CCUG 22020
143950	C. difficile CCUG 22023
145666	C. difficile CCUG 29183
148544	C. difficile CCUG 35620
149446	C. difficile CCUG 37767
149447	C. difficile CCUG 37768
149448	C. difficile CCUG 37769
149449	C. difficile CCUG 37770
149450	C. difficile CCUG 37771
149451	C. difficile CCUG 37772
149452	C. difficile CCUG 37773
149453	C. difficile CCUG 37774
149454	C. difficile CCUG 37775
149455	C. difficile CCUG 37776
149456	C. difficile CCUG 37777
149457	C. difficile CCUG 37778
149459	C. difficile CCUG 37781, ATCC 43597
149460	C. difficile CCUG 37783, ATCC 43599
149461	C. difficile CCUG 37785, ATCC 43601
149462	C. difficile CCUG 37787, ATCC 43603
149536	C. difficile CCUG 37922
151958	C. difficile CCUG 45344
151959	C. difficile CCUG 45345
152338	C. difficile CCUG 46468
152339	C. difficile CCUG 46469
152340	C. difficile CCUG 46470
154467	C. difficile CCUG 53741
154468	C. difficile CCUG 53742
154474	C. difficile CCUG 53749
154520	C. difficile CCUG 54206
156075	C. difficile CCUG 60275, LBM 08.01.040
156076	C. difficile CCUG 60276, LBM 08.01.058
156768	C. difficile CCUG 64977
156771	C. difficile CCUG 65028
157662	C. difficile 4167/2013 1, DSM 27638
157663	C. difficile 4167/2013 2, DSM 27639
157664	C. difficile 4167/2013 3, DSM 27640
157665	C. difficile SC037-01-01, 6551/2013, DSM 28196
157666	C. difficile SC052-01-01, DSM 29688
157667	C. difficile SC009-01-01, DSM 29745
157668	C. difficile SC052-02-01, DSM 29747
157669	C. difficile CD-16-113, D/6474/2015, DSM 102978
157670	C. difficile 3525/15, Goe-91, DSM 105001
158911	C. difficile 3022, CD3022, DSM 101085
165126	C. difficile JCM 5243
165127	C. difficile JCM 5244
165128	C. difficile JCM 5245
165129	C. difficile JCM 5246
165130	C. difficile JCM 5247
165131	C. difficile JCM 5248
165132	C. difficile JCM 5249
165133	C. difficile JCM 5250
165134	C. difficile JCM 5251
165135	C. difficile JCM 5252
165136	C. difficile JCM 5253
165137	C. difficile JCM 5254
165138	C. difficile JCM 5256
165139	C. difficile JCM 5257
165140	C. difficile JCM 5258
176413	C. difficile RT 023, DSM 102859
176414	C. difficile RT 127, DSM 102860

Morphology

Culture and growth conditions

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
53866	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

53866

Oxygen toleranceanaerobe

Isolation, sampling and environmental information

Interaction and safety

Sequence information

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	Emerging Diagnostics in Clostridioides difficile Infection.	Hulme JP.	Int J Mol Sci	10.3390/ijms25168672	2024
Pathogenicity	PPAR-gamma agonist mitigates intestinal barrier dysfunction and inflammation induced by Clostridioides difficile SlpA in vitro.	Noori M, Noori M, Azimirad M, Ghorbaninejad M, Meyfour A, Zali MR, Yadegar A.	Sci Rep	10.1038/s41598-024-83815-4	2024
	Novel metal peroxide nanoboxes restrain Clostridioides difficile infection beyond the bactericidal and sporicidal activity.	Yang LX, Lai YH, Cheung CI, Ye Z, Huang TC, Wang YC, Chin YC, Chia ZC, Chen YJ, Li MJ, Tseng HY, Tsai YT, Zhang ZB, Chen KH, Tsai BY, Shieh DB, Lee NY, Tsai PJ, Huang CC.	Bioeng Transl Med	10.1002/btm2.10593	2023
	Octahedron Iron Oxide Nanocrystals Prohibited Clostridium difficile Spore Germination and Attenuated Local and Systemic Inflammation.	Lee WT, Wu YN, Chen YH, Wu SR, Shih TM, Li TJ, Yang LX, Yeh CS, Tsai PJ, Shieh DB.	Sci Rep	10.1038/s41598-017-08387-y	2017
Metabolism	Membrane Cholesterol Is Crucial for Clostridium difficile Surface Layer Protein Binding and Triggering Inflammasome Activation.	Chen Y, Huang K, Chen LK, Wu HY, Hsu CY, Tsai YS, Ko WC, Tsai PJ.	Front Immunol	10.3389/fimmu.2020.01675	2020
Pathogenicity	Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on Clostridioides difficile.	Chandra H, Sharma KK, Tuovinen OH, Sun X, Shukla P.	Gut Microbes	10.1080/19490976.2021.1979882	2021
	The ATP-P2X₇ Signaling Axis Is an Essential Sentinel for Intracellular Clostridium difficile Pathogen-Induced Inflammasome Activation.	Liu YH, Chang YC, Chen LK, Su PA, Ko WC, Tsai YS, Chen YH, Lai HC, Wu CY, Hung YP, Tsai PJ.	Front Cell Infect Microbiol	10.3389/fcimb.2018.00084	2018
Metabolism	Development of TaqMan-based quantitative PCR for sensitive and selective detection of toxigenic Clostridium difficile in human stools.	Kubota H, Sakai T, Gawad A, Makino H, Akiyama T, Ishikawa E, Oishi K.	PLoS One	10.1371/journal.pone.0111684	2014
	Importance of Ultraviolet-C (UV-C) Emitter Configuration for Clostridioides difficile Attenuation.	Brindeiro CT, Dexter F, Parra MC, Walker KM, Hwang SM, Wanta BT, Szeluga DJ, Hadder BA, Seering MS, Charnin JE, Loftus RW.	Cureus	10.7759/cureus.71096	2024
	Efficacy of three chemical disinfectants and steam against Clostridioides difficile endospores on nylon carpet with two different backing systems.	Huang J, Fraser A, Jiang X.	Appl Environ Microbiol	10.1128/aem.00861-25	2025
	A rationally designed antimicrobial peptide from structural and functional insights of Clostridioides difficile translation initiation factor 1.	Alanis E, Aguilar F, Banaei N, Dean FB, Villarreal A, Alanis M, Lozano K, Bullard JM, Zhang Y.	Microbiol Spectr	10.1128/spectrum.02773-23	2024
	Comparison of rectal swabs and fecal samples for the detection of Clostridioides difficile infections with a new in-house PCR assay.	Huletsky A, Loo VG, Longtin Y, Longtin J, Trottier S, Tremblay CL, Gilca R, Lavallee C, Brochu E, Berube E, Bastien M, Bernier M, Gagnon M, Frenette J, Bestman-Smith J, Deschenes L, Bergeron MG.	Microbiol Spectr	10.1128/spectrum.00225-24	2024
	Comparison of clinical severity, genotype and toxin gene expression of binary toxin-producing Clostridioides difficile clinical isolates in Japan.	Matsumoto A, Yamagishi Y, Miyamoto K, Higashi S, Oka K, Takahashi M, Mikamo H.	Access Microbiol	10.1099/acmi.0.000362	2022
	Robust and Transparent Silver Oxide Coating Fabricated at Room Temperature Kills Clostridioides difficile Spores, MRSA, and Pseudomonas aeruginosa.	Hosseini M, Huang J, Williams MD, Gonzalez GA, Jiang X, Falkinham JO, Ducker WA.	Microorganisms	10.3390/microorganisms12010083	2023
	Chemical Profile and Biological Properties of Methanolic and Ethanolic Extracts from the Aerial Parts of Inula britannica L. Growing in Central Asia.	Ibadullayeva AK, Kasela M, Kozhanova KK, Kadyrbayeva GM, Widelski J, Wojtanowski K, Jozefczyk A, Susniak K, Okinczyc P, Tleubayeva MI, Karaubayeva AA, Zhandabayeva MA, Mukhamedsadykova AZ, Malm A.	Molecules	10.3390/molecules29235749	2024
Phylogeny	Rapid and reliable species-level identification from clinical samples using 16 S rRNA gene nanopore sequencing analysis.	Ivens MJR, Kamminga S, Benchamach K, Akile C, Wessels E, Claas ECJ, Boers SA.	Sci Rep	10.1038/s41598-025-14071-3	2025
	Efficacy of EPA-registered disinfectants against two human norovirus surrogates and Clostridioides difficile endospores.	Huang J, Park GW, Jones RM, Fraser AM, Vinje J, Jiang X.	J Appl Microbiol	10.1111/jam.15524	2022
	Development of a rapid-viability PCR method for detection of Clostridioides difficile spores from environmental samples.	Shams AM, Rose LJ, Noble-Wang JA.	Anaerobe	10.1016/j.anaerobe.2019.102077	2020
	Pterostilbene attenuates intestinal barrier damage and secondary liver oxidative stress in a murine model of Clostridium difficile infection by regulating the gut microbiota.	Yang H, Kuang Y, Wang L, Ma X, Galvez JAV, Lu J, Dai Y, Liu S, Yao J, Chen X, Cao Y.	Food Funct	10.1039/d4fo06413e	2025
	Characterization of the Dynamic Germination of Individual Clostridium difficile Spores Using Raman Spectroscopy and Differential Interference Contrast Microscopy.	Wang S, Shen A, Setlow P, Li YQ.	J Bacteriol	10.1128/jb.00200-15	2015
	Unlocking the Sporicidal Potential of Ethanol: Induced Sporicidal Activity of Ethanol against Clostridium difficile and Bacillus Spores under Altered Physical and Chemical Conditions.	Nerandzic MM, Sunkesula VC, C TS, Setlow P, Donskey CJ.	PLoS One	10.1371/journal.pone.0132805	2015
	DNA Damage Kills Bacterial Spores and Cells Exposed to 222-Nanometer UV Radiation.	Taylor W, Camilleri E, Craft DL, Korza G, Granados MR, Peterson J, Szczpaniak R, Weller SK, Moeller R, Douki T, Mok WWK, Setlow P.	Appl Environ Microbiol	10.1128/aem.03039-19	2020
	Inhibition of Clostridium difficile growth and adhesion to enterocytes by Bifidobacterium supernatants.	Trejo FM, Minnaard J, Perez PF, De Antoni GL.	Anaerobe	10.1016/j.anaerobe.2006.03.004	2006
Enzymology	Isolation of Toxigenic Clostridium difficile from Animal Manure and Composts Being Used as Biological Soil Amendments.	Dharmasena M, Jiang X.	Appl Environ Microbiol	10.1128/aem.00738-18	2018
	Evaluation of a hand-held far-ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens.	Nerandzic MM, Cadnum JL, Eckart KE, Donskey CJ.	BMC Infect Dis	10.1186/1471-2334-12-120	2012
Pathogenicity	Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile.	Rea MC, Sit CS, Clayton E, O'Connor PM, Whittal RM, Zheng J, Vederas JC, Ross RP, Hill C.	Proc Natl Acad Sci U S A	10.1073/pnas.0913554107	2010
Enzymology	Novel strategies for enhanced removal of persistent Bacillus anthracis surrogates and Clostridium difficile spores from skin.	Nerandzic MM, Rackaityte E, Jury LA, Eckart K, Donskey CJ.	PLoS One	10.1371/journal.pone.0068706	2013
Metabolism	Tigecycline exhibits inhibitory activity against Clostridium difficile in the colon of mice and does not promote growth or toxin production.	Jump RL, Li Y, Pultz MJ, Kypriotakis G, Donskey CJ.	Antimicrob Agents Chemother	10.1128/aac.00839-10	2011
Enzymology	A low complexity rapid molecular method for detection of Clostridium difficile in stool.	McElgunn CJ, Pereira CR, Parham NJ, Smythe JE, Wigglesworth MJ, Smielewska A, Parmar SA, Gandelman OA, Brown NM, Tisi LC, Curran MD.	PLoS One	10.1371/journal.pone.0083808	2014
Metabolism	Novel high-molecular-weight, R-type bacteriocins of Clostridium difficile.	Gebhart D, Williams SR, Bishop-Lilly KA, Govoni GR, Willner KM, Butani A, Sozhamannan S, Martin D, Fortier LC, Scholl D.	J Bacteriol	10.1128/jb.01272-12	2012
Pathogenicity	Effect of ceftobiprole treatment on growth of and toxin production by Clostridium difficile in cecal contents of mice.	Nerandzic MM, Donskey CJ.	Antimicrob Agents Chemother	10.1128/aac.01612-10	2011
Pathogenicity	Examination of potential mechanisms to explain the association between proton pump inhibitors and Clostridium difficile infection.	Nerandzic MM, Pultz MJ, Donskey CJ.	Antimicrob Agents Chemother	10.1128/aac.00252-09	2009
Pathogenicity	Evaluation of an automated ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms.	Nerandzic MM, Cadnum JL, Pultz MJ, Donskey CJ.	BMC Infect Dis	10.1186/1471-2334-10-197	2010
	Role of FliC and FliD flagellar proteins of Clostridium difficile in adherence and gut colonization.	Tasteyre A, Barc MC, Collignon A, Boureau H, Karjalainen T.	Infect Immun	10.1128/iai.69.12.7937-7940.2001	2001
	Triggering germination represents a novel strategy to enhance killing of Clostridium difficile spores.	Nerandzic MM, Donskey CJ.	PLoS One	10.1371/journal.pone.0012285	2010
Metabolism	Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice.	Pultz NJ, Donskey CJ.	Antimicrob Agents Chemother	10.1128/aac.49.8.3529-3532.2005	2005
Phylogeny	Comparison of typing methods for Clostridium difficile isolates.	Wolfhagen MJ, Fluit AC, Torensma R, Jansze M, Kuypers AF, Verhage EA, Verhoef J.	J Clin Microbiol	10.1128/jcm.31.8.2208-2211.1993	1993
Enzymology	Automated detection of toxigenic Clostridium difficile in clinical samples: isothermal tcdB amplification coupled to array-based detection.	Hicke B, Pasko C, Groves B, Ager E, Corpuz M, Frech G, Munns D, Smith W, Warcup A, Denys G, Ledeboer NA, Lindsey W, Owen C, Rea L, Jenison R.	J Clin Microbiol	10.1128/jcm.00621-12	2012
	Activate to eradicate: inhibition of Clostridium difficile spore outgrowth by the synergistic effects of osmotic activation and nisin.	Nerandzic MM, Donskey CJ.	PLoS One	10.1371/journal.pone.0054740	2013
Transcriptome	Array comparative hybridisation reveals a high degree of similarity between UK and European clinical isolates of hypervirulent Clostridium difficile.	Marsden GL, Davis IJ, Wright VJ, Sebaihia M, Kuijper EJ, Minton NP.	BMC Genomics	10.1186/1471-2164-11-389	2010
Metabolism	Molecular characterization of fliD gene encoding flagellar cap and its expression among Clostridium difficile isolates from different serogroups.	Tasteyre A, Karjalainen T, Avesani V, Delmee M, Collignon A, Bourlioux P, Barc MC.	J Clin Microbiol	10.1128/jcm.39.3.1178-1183.2001	2001
Genetics	Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota.	Rea MC, O'Sullivan O, Shanahan F, O'Toole PW, Stanton C, Ross RP, Hill C.	J Clin Microbiol	10.1128/jcm.05176-11	2012
Phylogeny	Comparison of PCR-ribotyping, arbitrarily primed PCR, and pulsed-field gel electrophoresis for typing Clostridium difficile.	Bidet P, Lalande V, Salauze B, Burghoffer B, Avesani V, Delmee M, Rossier A, Barbut F, Petit JC.	J Clin Microbiol	10.1128/jcm.38.7.2484-2487.2000	2000
Phylogeny	Clostridium difficile genotyping based on slpA variable region in S-layer gene sequence: an alternative to serotyping.	Karjalainen T, Saumier N, Barc MC, Delmee M, Collignon A.	J Clin Microbiol	10.1128/jcm.40.7.2452-2458.2002	2002
Pathogenicity	Memory of Germinant Stimuli in Bacterial Spores.	Wang S, Faeder JR, Setlow P, Li YQ.	mBio	10.1128/mbio.01859-15	2015
Phylogeny	Typing of Clostridium difficile by western immunoblotting with 10 different antisera.	Kato H, Cavallaro JJ, Kato N, Bartley SL, Killgore GE, Watanabe K, Ueno K.	J Clin Microbiol	10.1128/jcm.31.2.413-415.1993	1993
Phylogeny	Phenotypic and genotypic diversity of the flagellin gene (fliC) among Clostridium difficile isolates from different serogroups.	Tasteyre A, Karjalainen T, Avesani V, Delmee M, Collignon A, Bourlioux P, Barc MC.	J Clin Microbiol	10.1128/jcm.38.9.3179-3186.2000	2000
Pathogenicity	The potential for emerging therapeutic options for Clostridium difficile infection.	Mathur H, Rea MC, Cotter PD, Ross RP, Hill C.	Gut Microbes	10.4161/19490976.2014.983768	2014
Metabolism	A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity.	Gebhart D, Lok S, Clare S, Tomas M, Stares M, Scholl D, Donskey CJ, Lawley TD, Govoni GR.	mBio	10.1128/mbio.02368-14	2015
Enzymology	Rapid detection of toxigenic Clostridium difficile in fecal samples by magnetic immuno PCR assay.	Wolfhagen MJ, Fluit AC, Torensma R, Poppelier MJ, Verhoef J.	J Clin Microbiol	10.1128/jcm.32.7.1629-1633.1994	1994
Phylogeny	Use of an enzyme-linked immunoassay for Clostridium difficile serogrouping.	Delmee M, Depitre C, Corthier G, Ahoyo A, Avesani V.	J Clin Microbiol	10.1128/jcm.31.9.2526-2528.1993	1993
	Characterization of flagella of Clostridium difficile and their role in serogrouping reactions.	Delmee M, Avesani V, Delferriere N, Burtonboy G.	J Clin Microbiol	10.1128/jcm.28.10.2210-2214.1990	1990
Phylogeny	Improving culture media for the isolation of Clostridium difficile from compost.	Dharmasena M, Jiang X	Anaerobe	10.1016/j.anaerobe.2018.03.002	2018
Phylogeny	The mosaic nature of intergenic 16S-23S rRNA spacer regions suggests rRNA operon copy number variation in Clostridium difficile strains.	Sadeghifard N, Gurtler V, Beer M, Seviour RJ	Appl Environ Microbiol	10.1128/AEM.01179-06	2006
Pathogenicity	[A study on clinical application of a novel reagent detecting toxigenic strains of Clostridium difficile].	Wang SM, Wang ZY	Zhonghua Yi Xue Za Zhi	10.3760/cma.j.issn.0376-2491.2018.48.013	2018

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#53866	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 37780
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Clostridioides difficile (CCUG 37780, ATCC 43593)

Name and taxonomic classification

Morphology

Culture and growth conditions

Culture temp

Physiology and metabolism

Oxygen tolerance

Isolation, sampling and environmental information

Interaction and safety

Sequence information

Genome-based predictions

Literature

Literature

References

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