Streptococcus gordonii (DSM 6777, ATCC 10558, CIP 105258)

Name: Streptococcus gordonii (DSM 6777, ATCC 10558, CIP 105258)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 14790

Type strain

Strain Designation SK3, SK 3

Culture col. no. DSM 6777 ATCC 10558 CIP 105258 NCTC 7865 SK3 6 more

NCBI tax ID(s) 1302

Special Collections DSMZ CCUG JCM CIP

History DSMZ <- ATCC; ATCC 10558 <- J. M. Sherman; SK3 JCM <-- CCUG 33482 <-- NCTC 7865 <-- ATCC 10558 <-- J. M. Sherman. CIP <- 1997, DSMZ <- ATCC <- J.M. Sherman, Streptococcus sanguis: strain SK 3

Links

Streptococcus gordonii SK3 is a microaerophile, Gram-positive, coccus-shaped bacterium that was isolated from subacute bacterial endocarditis, human.

Gram-positive coccus-shaped microaerophile genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 10362

LMG 14518,ATCC 10558,CCUG 25608,NCTC 7865,CCUG 33482,CCUG 35801,CIP 105258,DSM 6777,KCTC 3286,BCRC 14731,CCRC 14731,JCM 12995,CNCTC 6731,CGMCC 1.2496

@ref 20215

Last LPSN update 2026-05-29 08:28:22

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Streptococcaceae

Genus Streptococcus

Species Streptococcus gordonii

Full scientific name Streptococcus gordonii Kilian et al. 1989

BacDive ID	Other strains from **Streptococcus gordonii** (53)	Type strain
14791	S. gordonii SK 51, DSM 20568, ATCC 33399, NCTC 3165, ...
135109	S. gordonii Challis, CIP 110914, NCTC 7868, NCTC 5337
136743	S. gordonii GN72, LMG 14549, CIP 105038, CCUG 28204
137101	S. gordonii H11, CIP 55.121
139476	S. gordonii BM120, CIP 105336
141638	S. gordonii CCUG 4216, NCTC 10231, LMG 14515
144962	S. gordonii CCUG 27309
144963	S. gordonii CCUG 27310
144964	S. gordonii CCUG 27312
144965	S. gordonii CCUG 27313
145044	S. gordonii CCUG 27509
145045	S. gordonii CCUG 27510
145046	S. gordonii CCUG 27511
145047	S. gordonii CCUG 27515 A
146448	S. gordonii CCUG 31163
146804	S. gordonii CCUG 32146
146927	S. gordonii CCUG 32460
147163	S. gordonii CCUG 32974
147267	S. gordonii CCUG 33229
147340	S. gordonii CCUG 33396
147931	S. gordonii CCUG 34533
148249	S. gordonii CCUG 35100
148363	S. gordonii CCUG 35287
148632	S. gordonii CCUG 35746
148641	S. gordonii CCUG 35757
148642	S. gordonii CCUG 35758
148643	S. gordonii CCUG 35759
148644	S. gordonii CCUG 35760
148645	S. gordonii CCUG 35761
148646	S. gordonii CCUG 35762
148901	S. gordonii CCUG 36568
149226	S. gordonii CCUG 37297
149527	S. gordonii CCUG 37907
149990	S. gordonii CCUG 38808
150298	S. gordonii CCUG 39571
150300	S. gordonii CCUG 39576
150769	S. gordonii CCUG 42257
151092	S. gordonii CCUG 43252
151122	S. gordonii CCUG 43322
151929	S. gordonii CCUG 45239
152180	S. gordonii CCUG 45984
152992	S. gordonii CCUG 48204
153202	S. gordonii CCUG 48709
153534	S. gordonii CCUG 50099
153669	S. gordonii CCUG 50583
153683	S. gordonii CCUG 50640
153769	S. gordonii CCUG 50919
153898	S. gordonii CCUG 51552
154594	S. gordonii CCUG 54513
155056	S. gordonii CCUG 56319
155487	S. gordonii CCUG 57864
156032	S. gordonii CCUG 60137
156036	S. gordonii CCUG 60144

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
125438				90.5
119711	positive	coccus-shaped

Colony morphology

@ref	Type of hemolysis	Hemolysis ability	Incubation period
2811	alpha	1	1-2 days
119711		0

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
2811	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
2811	TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)	Medium recipe at MediaDive	Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water
42091	MEDIUM 29- Brain heart agar		Distilled water make up to (1000.000 ml);Brain heart infusion agar (52.000 g)
119711	CIP Medium 72	Medium recipe at CIP
119711	CIP Medium 29	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
2811	positive	growth	37
42091	positive	growth	37
67770	positive	growth	37
119711	positive	growth	25-41
119711	negative	growth	10
119711	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
2811	microaerophile
119711	facultative anaerobe
125439	facultative anaerobe	93.484

Spore formation

@ref	Spore formation	Confidence
125439		98.306

Halophily

@ref	Salt	Growth	Tested relation	Concentration
119711	NaCl		growth	6.5 %

Murein

@ref	Murein short key	Type
2811	A11.05	A3alpha L-Lys-L-Ala₂

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68381	40585 ChEBI	alpha-cyclodextrin	-	builds acid from	from API rID32STR
68381	29016 ChEBI	arginine	-	hydrolysis	from API rID32STR
68381	18333 ChEBI	D-arabitol	-	builds acid from	from API rID32STR
68381	16899 ChEBI	D-mannitol	-	builds acid from	from API rID32STR
119711	4853 ChEBI	esculin	+	hydrolysis
68381	28087 ChEBI	glycogen	-	builds acid from	from API rID32STR
119711	606565 ChEBI	hippurate	-	hydrolysis
68381	30849 ChEBI	L-arabinose	-	builds acid from	from API rID32STR
68381	17716 ChEBI	lactose	+	builds acid from	from API rID32STR
68381	17306 ChEBI	maltose	+	builds acid from	from API rID32STR
68381	6731 ChEBI	melezitose	-	builds acid from	from API rID32STR
68381	28053 ChEBI	melibiose	-	builds acid from	from API rID32STR
119711	17632 ChEBI	nitrate	-	reduction
119711	16301 ChEBI	nitrite	-	reduction
68381	27941 ChEBI	pullulan	-	builds acid from	from API rID32STR
68381	16634 ChEBI	raffinose	-	builds acid from	from API rID32STR
68381	30911 ChEBI	sorbitol	-	builds acid from	from API rID32STR
68381	17992 ChEBI	sucrose	+	builds acid from	from API rID32STR
68381	27082 ChEBI	trehalose	+	builds acid from	from API rID32STR
68381	16199 ChEBI	urea	-	hydrolysis	from API rID32STR

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68381	15688 ChEBI	acetoin		from API rID32STR

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test
68381	15688 ChEBI	acetoin	-	from API rID32STR
119711	15688 ChEBI	acetoin	-

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68381	Alanyl-Phenylalanyl-Proline arylamidase	+		from API rID32STR
119711	alcohol dehydrogenase	+	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68381	arginine dihydrolase	-	3.5.3.6	from API rID32STR
68382	beta-galactosidase	+	3.2.1.23	from API zym
119711	beta-galactosidase	+	3.2.1.23
68381	beta-glucosidase	+	3.2.1.21	from API rID32STR
68382	beta-glucosidase	+	3.2.1.21	from API zym
68381	beta-glucuronidase	-	3.2.1.31	from API rID32STR
68382	beta-glucuronidase	-	3.2.1.31	from API zym
2811	catalase	-	1.11.1.6
119711	catalase	-	1.11.1.6
68382	cystine arylamidase	+	3.4.11.3	from API zym
2811	cytochrome-c oxidase	-	1.9.3.1
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
119711	gamma-glutamyltransferase	-	2.3.2.2
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	+		from API zym
119711	lysine decarboxylase	-	4.1.1.18
68381	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32STR
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
119711	ornithine decarboxylase	-	4.1.1.17
119711	oxidase	-
68381	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32STR
68382	trypsin	-	3.4.21.4	from API zym
68381	urease	-	3.5.1.5	from API rID32STR
68382	valine arylamidase	+		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
119711	-	+	+	+	+	+	+	+	-	-	+	+	-	+	-	+	+	-	-	-

API rID32STR

@ref	ADH (Arg)	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	TAG	beta MAN	URE
2811	-	+	+	-	+/-	+	-	-	-	+	+	-	+	-	-	-	-	+	+	-	-	+	-	-	-	+	-	-	+	+	+	-
2811	-	+	+	-	-	+	-	-	-	+	+	-	+	-	-	-	-	+	+	-	-	+	-	-	-	+	-	-	+	+	+	-
2811	-	+	+	-	-	+	-	-	-	+	+	-	+	-	-	-	-	+	+	-	-	-	-	-	-	+	-	-	+	+	+/-	-
2811	-	+	-	-	-	-	+	-	-	+	+	-	+	-	-	-	-	+	-	-	-	-	-	-	-	+	-	-	-	+	-	-
2811	-	+	-	-	-	+	-	-	-	+	+	-	+	-	-	-	-	+	-	-	-	-	+	-	-	+	-	-	-	+/-	-	-
2811	-	+	+	-	-	+	+/-	-	-	+	+	-	+	-	-	-	-	+	-	-	-	-	-	-	-	+	-	-	-	+	+	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Infection	#Disease	-
#Host	#Microbial	#Bacteria
#Host Body-Site	#Organ	#Heart

Isolation

@ref	Sample type	Host species
2811	subacute bacterial endocarditis, human	Homo sapiens
67770	Human subacute endocarditis	Homo sapiens
119711	Subacute bacterial endocarditis

Taxonmaps

69479

Global distribution of 16S sequence LC258133 (>99% sequence identity) for Streptococcus from Microbeatlas

Aquatic Samples	4744
Soil Samples	2729
Animal Samples	143458
Plant Samples	1045
Total Samples	151976

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
2811	2	Risk group (German classification) According to TRBA 466
119711	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
124043	ASM1904694v1 assembly for Streptococcus gordonii FDAARGOS 1454	complete	GCA_019046945	1302.425	8120286010	1302	99.51
66792	41975_E01 assembly for Streptococcus gordonii NCTC7865	complete	GCA_900475015	1302.168	8115644048	1302	98.49
66792	ASM155385v1 assembly for Streptococcus gordonii CCUG 33482	scaffold	GCA_001553855	1302.20	2728369123	1302	68.94
66792	ASM146929v1 assembly for Streptococcus gordonii ATCC 10558	scaffold	GCA_001469295	1302.19	2823469221	1302	65.47

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptococcus gordonii DNA, 16S-23S rRNA intergenic spacer region	AB051019	246	1302
20218	Streptococcus gordonii 16S ribosomal RNA gene, complete sequence	AF003931	1512	1302
20218	Streptococcus gordonii strain ATCC 10558 16S-23S ribosomal RNA intergenic spacer, partial sequence	AY353081	246	1302
20218	Streptococcus gordonii strain ATCC 10558 16S small subunit ribosomal RNA gene, partial sequence	AY485606	1479	1302
20218	Streptococcus gordonii strain ATCC 10558 16S ribosomal RNA gene, partial sequence	EU156758	1329	1302
20218	Streptococcus gordonii strain ATCC 10558 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA internal transcribed spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence	JN181383	511	1302
20218	Streptococcus gordonii strain KCTC 3286 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence	HM241933	458	1302
20218	Streptococcus gordonii 16S rRNA gene	D38483	1413	1302
20218	Streptococcus gordonii strain NCTC 7865 16S-23S ribosomal RNA intergenic spacer, partial sequence	EU860346	323	1302
67770	Streptococcus gordonii gene for 16S ribosomal RNA, partial sequence, strain: JCM 12995	LC258133	1498	1302
124043	Streptococcus gordonii ATCC 10558 gene for 16S rRNA, partial sequence.	LC752418	588	1302

GC content

@ref	GC-content (mol%)	Method
2811	41.0	thermal denaturation, midpoint method (Tm)
67770	41

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM1904694v1 assembly for Streptococcus gordonii FDAARGOS 1454
NCBI: GCA_019046945

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	93.48	no
125439	gram_stain	BacteriaNetⓘ	positive	81.83	no
125439	motility	BacteriaNetⓘ	no	87.47	no
125439	spore_formation	BacteriaNetⓘ	no	98.31	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptococcus gordonii NCTC7865
NCBI: GCA_900475015.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	87.39	no
125438	anaerobic	anaerobicⓘ	no	86.12	yes
125438	aerobic	aerobicⓘ	no	95.48	yes
125438	spore-forming	spore-formingⓘ	no	82.10	no
125438	thermophilic	thermophileⓘ	no	95.78	yes
125438	flagellated	motile2+ⓘ	no	90.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Inhibitory effect of natural flavone luteolin on Streptococcus mutans biofilm formation.	Rudin L, Roth N, Kneubuhler J, Dubey BN, Bornstein MM, Shyp V.	Microbiol Spectr	10.1128/spectrum.05223-22	2023
	Surface properties and initial bacterial biofilm growth on 3D-printed oral appliances: a comparative in vitro study.	Wuersching SN, Westphal D, Stawarczyk B, Edelhoff D, Kollmuss M.	Clin Oral Investig	10.1007/s00784-022-04838-7	2023
	Evaluation of microbiota associated with Herpesviruses in active sites of generalized aggressive periodontitis.	Passariello C, Gigola P, Testarelli L, Puttini M, Schippa S, Petti S.	Ann Stomatol (Roma)	10.11138/ads/2017.8.2.071	2017
Enzymology	Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs.	Wernecke M, Mullen C, Sharma V, Morrison J, Barry T, Maher M, Smith T.	BMC Infect Dis	10.1186/1471-2334-9-148	2009
	In-Vitro Effect of Manuka Honey / Propolis Toothpastes on Bacteria and Biofilm Associated with Caries and Gingivitis.	Jungbauer G, Lechner R, Stahli A, Sculean A, Eick S.	Oral Health Prev Dent	10.3290/j.ohpd.c_1910	2025
	Microbial Coaggregation in the Oral Cavity: Molecular Interactions and Current Insights.	Oogai Y, Tanaka Y, Nakata M.	Int J Mol Sci	10.3390/ijms262110552	2025
	Effect of Surface Wettability and Energy on Bacterial Adhesion to Dental Aligners: A Comparative In Vitro Study.	Martinez Gil-Ortega A, Paz-Cortes MM, Vinas MJ, Cintora-Lopez P, Martin-Vacas A, Gil J, Aragoneses JM.	Bioengineering (Basel)	10.3390/bioengineering12090898	2025
	Inhibitory effect of helium cold atmospheric plasma on cariogenic biofilms.	Figueira LW, Bessa Muniz A, Doria ACOC, Castaldelli Nishime TM, Kostov KG, Koga-Ito CY.	J Oral Microbiol	10.1080/20002297.2024.2397831	2024
	Effect of sodium hypochlorite gel on bacteria associated with periodontal disease.	Irani D, Jungbauer G, Sculean A, Eick S.	Clin Oral Investig	10.1007/s00784-023-05446-9	2024
	Silica nanoparticles containing nano-silver and chlorhexidine to suppress Porphyromonas gingivalis biofilm and modulate multispecies biofilms toward healthy tendency.	Fang L, Zhang Y, Cheng L, Zheng H, Wang Y, Qin L, Cai Y, Cheng L, Zhou W, Liu F, Wang S.	J Oral Microbiol	10.1080/20002297.2024.2361403	2024
Pathogenicity	Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques.	Karhunen PJ, Pessi T, Horkko S, Karhunen V, Goebeler S, Louhelainen AM, Martiskainen M, Haapaniemi T, Lappetelainen J, Ijas T, Lyytikainen LP, Raitoharju E, Sioris T, Tuomisto S, Huhtala H, Wang C, Monaco C, Oksala N, Lehtimaki T, Laaksonen R.	J Am Heart Assoc	10.1161/jaha.125.041521	2025
	In-vitro effect of different instrumentations on adhesion of a multispecies bacterial mixture to root surfaces and the subsequent response of pulpal cells.	Stahli A, Feuz S, Jutzi AE, Berto LP, Nietzsche S, Sculean A, Eick S.	Clin Oral Investig	10.1007/s00784-025-06321-5	2025
	Effect of scaling on the invasion of oral microorganisms into dentinal tubules including the response of pulpal cells-an in vitro study.	Stahli A, Schatt ASJ, Stoffel M, Nietzsche S, Sculean A, Gruber R, Cvikl B, Eick S.	Clin Oral Investig	10.1007/s00784-020-03705-7	2021
	Antibacterial activity and biocompatibility of silver coating via aerosol deposition on titanium and zirconia surfaces.	Choi S, Jo YH, Han JS, Yoon HI, Lee JH, Yeo IL.	Int J Implant Dent	10.1186/s40729-023-00488-w	2023
Pathogenicity	Dietary Fibre Modulates Body Composition, Blood Glucose, Inflammation, Microbiome, and Metabolome in a Murine Model of Periodontitis.	Jayasinghe T, Jenkins J, Medara N, Choowong P, Dharmarathne G, Kong F, Cho H, Kim SH, Zhang Y, Franco-Duarte R, Eberhard J, Spahr A.	Nutrients	10.3390/nu17071146	2025
	Study of an arginine- and tryptophan-rich antimicrobial peptide in peri-implantitis.	Zhang Q, Jiang Y, He X, Liu L, Zhang X.	Front Bioeng Biotechnol	10.3389/fbioe.2024.1486213	2024
	Salivary pellicle modulates biofilm formation on titanium surfaces.	Martinez-Hernandez M, Reyes-Grajeda JP, Hannig M, Almaguer-Flores A.	Clin Oral Investig	10.1007/s00784-023-05230-9	2023
	The effect of surface material, roughness and wettability on the adhesion and proliferation of Streptococcus gordonii, Fusobacterium nucleatum and Porphyromonas gingivalis.	Choi S, Jo YH, Luke Yeo IS, Yoon HI, Lee JH, Han JS.	J Dent Sci	10.1016/j.jds.2022.09.010	2023
	Screening and characterization of aptamers recognizing the periodontal pathogen Tannerella forsythia.	Mizgalska D, Malicki S, Golda A, Chruscicka-Smaga B, Potempa J.	FEBS Open Bio	10.1002/2211-5463.13772	2024
	Thrombus Aspirates From Patients With Acute Ischemic Stroke Are Infiltrated by Viridans Streptococci.	Patrakka O, Tuomisto S, Pienimaki JP, Ollikainen J, Oksala N, Lampinen V, Ojanen MJT, Huhtala H, Hytonen VP, Lehtimaki T, Martiskainen M, Karhunen PJ.	J Am Heart Assoc	10.1161/jaha.123.030639	2023
	Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in beta-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci.	Nomura R, Suehiro Y, Tojo F, Matayoshi S, Okawa R, Hamada M, Naka S, Matsumoto-Nakano M, Unesaki R, Koumoto K, Kawauchi K, Nishikata T, Akitomo T, Mitsuhata C, Yagi M, Mizoguchi T, Fujikawa K, Taniguchi T, Nakano K.	Int J Mol Sci	10.3390/ijms25021075	2024
Pathogenicity	Spent culture supernatant of Streptococcus gordonii mitigates inflammation of human periodontal cells and inhibits proliferation of pathogenic oral microbes.	Shu Y, Upara C, Ding Q, Zhu M, Zeng E, Banas JA, Hong L.	J Periodontol	10.1002/jper.22-0333	2023
	Antimicrobial Activity of Methylene Blue Associated with Photodynamic Therapy: In Vitro Study in Multi-Species Oral Biofilm.	Bueno-Silva B, Parma-Garcia J, Frigo L, Suarez LJ, Macedo TT, Uyeda FH, Melo MARDC, Sacco R, Mourao CF, Feres M, Shibli JA, Figueiredo LC.	Pathogens	10.3390/pathogens13040342	2024
	Lactobacillus acidophilus impairs the establishment of pathogens in a subgingival multispecies biofilm.	Bueno MR, Dudu-Silva G, Macedo TT, Gomes APAP, Rodrigues Oliveira Braga A, Aguiar Silva LD, Bueno-Silva B.	Front Dent Med	10.3389/fdmed.2023.1212773	2023
	Genomic and phenotypic characterization of Streptococcus mutans isolates suggests key gene clusters in regulating its interaction with Streptococcus gordonii.	Liu S, Sun Y, Liu Y, Hu F, Xu L, Zheng Q, Wang Q, Zeng G, Zhang K.	Front Microbiol	10.3389/fmicb.2022.945108	2022
	Evaluation of the Microbial Profile on the Polydioxanone Membrane and the Collagen Membrane Exposed to Multi-Species Subgingival Biofilm: An In Vitro Study.	Cintra Moreira MV, Figueiredo LC, da Cunha Melo MAR, Uyeda FH, da Silva LDA, Macedo TT, Sacco R, Mourao CF, Shibli JA, Bueno-Silva B.	Membranes (Basel)	10.3390/membranes13120907	2023
Pathogenicity	In vitro investigation of the antibacterial and anti-inflammatory effects of LED irradiation.	Lee J, Song HY, Ahn SH, Song W, Seol YJ, Lee YM, Koo KT.	J Periodontal Implant Sci	10.5051/jpis.2200920046	2023
	In Vitro Activity of Propolis on Oral Microorganisms and Biofilms.	Stahli A, Schroter H, Bullitta S, Serralutzu F, Dore A, Nietzsche S, Milia E, Sculean A, Eick S.	Antibiotics (Basel)	10.3390/antibiotics10091045	2021
	Tetrahedral framework nucleic acid-based small-molecule inhibitor delivery for ecological prevention of biofilm.	Liu Y, Li K, Zhuang W, Liang L, Chen X, Yu D.	Cell Prolif	10.1111/cpr.13678	2024
	Effect of etchant containing an Urushiol monomer from lacquer sap on dentin biostability and bonding performance.	Zhao Y, Xu X, Li L, Zheng K, Wang X, Zhang M, Xu Y.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1251655	2023
	An In Vitro study to Compare Dental Laser with other Treatment Modalities on Biofilm Ablation from Implant and Tooth Surfaces.	Vaddamanu SK, Vyas R, Kavita K, Sushma R, Rani RP, Dixit A, Badiyani BK.	J Pharm Bioallied Sci	10.4103/jpbs.jpbs_98_22	2022
	Multimodal inhibitory effect of matcha on Porphyromonas gingivalis.	Nakao R, Takatsuka A, Mandokoro K, Narisawa N, Ikeda T, Takai H, Ogata Y.	Microbiol Spectr	10.1128/spectrum.03426-23	2024
	The In-Vitro Activity of a Cold Atmospheric Plasma Device Utilizing Ambient Air against Bacteria and Biofilms Associated with Periodontal or Peri-Implant Diseases.	Jungbauer G, Favaro L, Muller S, Sculean A, Eick S.	Antibiotics (Basel)	10.3390/antibiotics11060752	2022
	Antibacterial and Bactericidal Effects of the Er: YAG Laser on Oral Bacteria: A Systematic Review of Microbiological Evidence.	Fiegler-Rudol J, Skaba D, Kawczyk-Krupka A, Wiench R.	J Funct Biomater	10.3390/jfb16060209	2025
Pathogenicity	Impact of honey on dental erosion and adhesion of early bacterial colonizers.	Habluetzel A, Schmid C, Carvalho TS, Lussi A, Eick S.	Sci Rep	10.1038/s41598-018-29188-x	2018
Metabolism	Identification and characterization of a novel Fusobacterium nucleatum adhesin involved in physical interaction and biofilm formation with Streptococcus gordonii.	Lima BP, Shi W, Lux R.	Microbiologyopen	10.1002/mbo3.444	2017
	In Vitro Evaluation of Antimicrobial Activity of Minocycline Formulations for Topical Application in Periodontal Therapy.	Schmid JL, Kirchberg M, Sarembe S, Kiesow A, Sculean A, Mader K, Buchholz M, Eick S.	Pharmaceutics	10.3390/pharmaceutics12040352	2020
	Anti-biofilm Activity of Oral Health-care Products Containing Chlorhexidine Digluconate and Citrox.	Jeyakumar J, Sculean A, Eick S.	Oral Health Prev Dent	10.3290/j.ohpd.a45437	2020
	In vitro activity of hyaluronic acid and human serum on periodontal biofilm and periodontal ligament fibroblasts.	Zhu X, von Werdt L, Zappala G, Sculean A, Eick S, Stahli A.	Clin Oral Investig	10.1007/s00784-023-05121-z	2023
	The antibacterial effect of sonication and its potential medical application.	Kamineni S, Huang C.	SICOT J	10.1051/sicotj/2019017	2019
	Oral mitis group streptococci reduce infectivity of influenza A virus via acidification and H2O2 production.	Okahashi N, Sumitomo T, Nakata M, Kuwata H, Kawabata S.	PLoS One	10.1371/journal.pone.0276293	2022
	Dual roles of photosynthetic hydrogel with sustained oxygen generation in promoting cell survival and eradicating anaerobic infection.	Kang J, Liang Y, Liu J, Hu M, Lin S, Zhong J, Wang C, Zeng Q, Zhang C.	Mater Today Bio	10.1016/j.mtbio.2024.101197	2024
	Cold Atmospheric Plasma Jet as a Possible Adjuvant Therapy for Periodontal Disease.	Lima GMG, Borges AC, Nishime TMC, Santana-Melo GF, Kostov KG, Mayer MPA, Koga-Ito CY.	Molecules	10.3390/molecules26185590	2021
Pathogenicity	Sonic irrigant activation for root canal disinfection: power modes matter!	Eggmann F, Vokac Y, Eick S, Neuhaus KW.	BMC Oral Health	10.1186/s12903-020-01088-5	2020
Pathogenicity	In-vitro effects of different hyaluronic acids on periodontal biofilm-immune cell interaction.	Zhu X, Sculean A, Eick S.	Front Cell Infect Microbiol	10.3389/fcimb.2024.1414861	2024
Pathogenicity	Ebselen Optimized the Therapeutic Effects of Silver Nanoparticles for Periodontal Treatment.	Liang Y, Wang B, Yu Q, Wang W, Ge S, Shao J.	Int J Nanomedicine	10.2147/ijn.s434579	2023
	Effect of Calcium Chloride Hydrothermal Treatment of Titanium on Protein, Cellular, and Bacterial Adhesion Properties.	Haraguchi T, Ayukawa Y, Shibata Y, Takeshita T, Atsuta I, Ogino Y, Yasunami N, Yamashita Y, Koyano K.	J Clin Med	10.3390/jcm9082627	2020
	Antibacterial and Anti-Inflammatory Properties of Peptide KN-17.	Zhang Q, Yu S, Hu M, Liu Z, Yu P, Li C, Zhang X.	Microorganisms	10.3390/microorganisms10112114	2022
	Selective activities of STAMPs against Streptococcus mutans.	Huo L, Huang X, Ling J, Liu H, Liu J.	Exp Ther Med	10.3892/etm.2017.5631	2018
	mucG, mucH, and mucI Modulate Production of Mutanocyclin and Reutericyclins in Streptococcus mutans B04Sm5.	Baker JL, Tang X, LaBonte S, Uranga C, Edlund A.	J Bacteriol	10.1128/jb.00042-22	2022
	Periodontitis induces endothelial dysfunction in mice.	Parvaneh M, Witting PK, Ku J, Moradi T, Eroglu E, Freedman B, Sutherland GT, McCorkindale A, Guennewig B, Choowong P, Bell-Anderson K, Cooney G, Thomas SR, Eberhard J.	Sci Rep	10.1038/s41598-021-94418-8	2021
Pathogenicity	Starvation Survival and Biofilm Formation under Subminimum Inhibitory Concentration of QAMs.	Tiwari SK, Wang S, Huang Y, Zhou X, Xu HHK, Ren B, Peng X, Xiao Y, Li M, Cheng L.	Biomed Res Int	10.1155/2021/8461245	2021
Metabolism	Porphyromonas gingivalis HmuY and Streptococcus gordonii GAPDH-Novel Heme Acquisition Strategy in the Oral Microbiome.	Slezak P, Smiga M, Smalley JW, Sieminska K, Olczak T.	Int J Mol Sci	10.3390/ijms21114150	2020
	In Vitro Comparison of the Efficacy of Peri-Implantitis Treatments on the Removal and Recolonization of Streptococcus gordonii Biofilm on Titanium Disks.	Toma S, Behets C, Brecx MC, Lasserre JF.	Materials (Basel)	10.3390/ma11122484	2018
	cAMP-independent Crp homolog adds to the multi-layer regulatory network in Porphyromonas gingivalis.	Smiga M, Roszkiewicz E, Slezak P, Tracz M, Olczak T.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1535009	2025
	Pellicle Modification with Casein and Mucin Does Not Promote In Vitro Bacterial Biofilm Formation.	Carvalho TS, Halter JE, Mucolli D, Lussi A, Eick S, Baumann T.	Oral Health Prev Dent	10.3290/j.ohpd.a43351	2020
	Gymnemic Acids Inhibit Adhesive Nanofibrillar Mediated Streptococcus gordonii-Candida albicans Mono-Species and Dual-Species Biofilms.	Veerapandian R, Vediyappan G.	Front Microbiol	10.3389/fmicb.2019.02328	2019
	Ursolic acid: biological functions and application in animal husbandry.	Liu G, Qin P, Cheng X, Wu L, Wang R, Gao W.	Front Vet Sci	10.3389/fvets.2023.1251248	2023
	Biofilm formation on polyetheretherketone and titanium surfaces.	Barkarmo S, Longhorn D, Leer K, Johansson CB, Stenport V, Franco-Tabares S, Kuehne SA, Sammons R.	Clin Exp Dent Res	10.1002/cre2.205	2019
	Er:YAG Laser Irradiation Reduces Microbial Viability When Used in Combination with Irrigation with Sodium Hypochlorite, Chlorhexidine, and Hydrogen Peroxide.	Golob Deeb J, Smith J, Belvin BR, Lewis J, Grzech-Lesniak K.	Microorganisms	10.3390/microorganisms7120612	2019
	Brazilian Red Propolis Is as Effective as Amoxicillin in Controlling Red-Complex of Multispecies Subgingival Mature Biofilm In Vitro.	de Figueiredo KA, da Silva HDP, Miranda SLF, Goncalves FJDS, de Sousa AP, de Figueiredo LC, Feres M, Bueno-Silva B.	Antibiotics (Basel)	10.3390/antibiotics9080432	2020
	Prevalence, diversity and transferability of the Tn916-Tn1545 family ICE in oral streptococci.	Lunde TM, Hjerde E, Al-Haroni M.	J Oral Microbiol	10.1080/20002297.2021.1896874	2021
	Metabolic activity of hydro-carbon-oxo-borate on a multispecies subgingival periodontal biofilm: a short communication.	Shibli JA, Rocha TF, Coelho F, de Oliveira Capote TS, Saska S, Melo MA, Pingueiro JMS, de Faveri M, Bueno-Silva B.	Clin Oral Investig	10.1007/s00784-021-03900-0	2021
Pathogenicity	The inhibitory effect of quaternary ammonium salt on bacteria in root canal.	Kumar Tiwari S, Guo X, Huang Y, Zhou X, Xu HHK, Ren B, Peng X, Weir MD, Li M, Cheng L.	Sci Rep	10.1038/s41598-019-48666-4	2019
	Curry Leaf Triggers Cell Death of P. gingivalis with Membrane Blebbing.	Nakao R, Ikeda T, Furukawa S, Morinaga Y.	Pathogens	10.3390/pathogens10101286	2021
	Role of Neuraminidase-Producing Bacteria in Exposing Cryptic Carbohydrate Receptors for Streptococcus gordonii Adherence.	Wong A, Grau MA, Singh AK, Woodiga SA, King SJ.	Infect Immun	10.1128/iai.00068-18	2018
Pathogenicity	Effects of Antimicrobial Peptide GH12 on the Cariogenic Properties and Composition of a Cariogenic Multispecies Biofilm.	Jiang W, Wang Y, Luo J, Li X, Zhou X, Li W, Zhang L.	Appl Environ Microbiol	10.1128/aem.01423-18	2018
Pathogenicity	Antibacterial Activity of a Bioactive Tooth-Coating Material Containing Surface Pre-Reacted Glass in a Complex Multispecies Subgingival Biofilm.	Tanaka CJ, Rodrigues JA, Pingueiro JMS, Macedo TT, Feres M, Shibli JA, Bueno-Silva B.	Pharmaceutics	10.3390/pharmaceutics15061727	2023
Enzymology	Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis.	Kaminska M, Aliko A, Hellvard A, Bielecka E, Binder V, Marczyk A, Potempa J, Delaleu N, Kantyka T, Mydel P.	J Periodontol	10.1002/jper.18-0179	2019
Phylogeny	Characterization of the arginolytic microflora provides insights into pH homeostasis in human oral biofilms.	Huang X, Schulte RM, Burne RA, Nascimento MM.	Caries Res	10.1159/000365296	2015
	The Pharmaceutical Ability of Pistacia lentiscus L. Leaves Essential Oil Against Periodontal Bacteria and Candida sp. and Its Anti-Inflammatory Potential.	Milia E, Usai M, Szotakova B, Elstnerova M, Kralova V, D'hallewin G, Spissu Y, Barberis A, Marchetti M, Bortone A, Campanella V, Mastandrea G, Langhansova L, Eick S.	Antibiotics (Basel)	10.3390/antibiotics9060281	2020
	Insight into the Effect of Small RNA srn225147 on Mutacin IV in Streptococcus mutans.	Liu S, Li H, Guo Z, Guan J, Sun Y, Zhang K.	Indian J Microbiol	10.1007/s12088-019-00820-2	2019
Pathogenicity	Cytotoxicity and Antimicrobial Activity of Oral Rinses In Vitro.	Muller HD, Eick S, Moritz A, Lussi A, Gruber R.	Biomed Res Int	10.1155/2017/4019723	2017
	Bovine Milk and Yogurt Affect Oral Microorganisms and Biofilms In-Vitro.	Tennert C, Sarra G, Stahli A, Sculean A, Eick S.	Oral Health Prev Dent	10.3290/j.ohpd.b3920023	2023
	Antibacterial, Hydrophilic Effect and Mechanical Properties of Orthodontic Resin Coated with UV-Responsive Photocatalyst.	Kuroiwa A, Nomura Y, Ochiai T, Sudo T, Nomoto R, Hayakawa T, Kanzaki H, Nakamura Y, Hanada N.	Materials (Basel)	10.3390/ma11060889	2018
Metabolism	Modulation of Candida albicans virulence in in vitro biofilms by oral bacteria.	Morse DJ, Wilson MJ, Wei X, Bradshaw DJ, Lewis MAO, Williams DW.	Lett Appl Microbiol	10.1111/lam.13145	2019
	Propolis, Aloe Vera, Green Tea, Cranberry, Calendula, Myrrha and Salvia Properties against Periodontal Microorganisms.	Figueiredo LC, Freitas Figueiredo N, da Cruz DF, Baccelli GT, Sarachini GE, Bueno MR, Feres M, Bueno-Silva B.	Microorganisms	10.3390/microorganisms10112172	2022
Pathogenicity	In-vitro antibiofilm activity of chlorhexidine digluconate on polylactide-based and collagen-based membranes.	Rudolf JL, Moser C, Sculean A, Eick S.	BMC Oral Health	10.1186/s12903-019-0979-y	2019
	Diversity in Antagonistic Interactions between Commensal Oral Streptococci and Streptococcus mutans.	Huang X, Browngardt CM, Jiang M, Ahn SJ, Burne RA, Nascimento MM.	Caries Res	10.1159/000479091	2018
	The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans.	Senpuku H, Tuna EB, Nagasawa R, Nakao R, Ohnishi M.	PLoS One	10.1371/journal.pone.0225584	2019
Pathogenicity	Biofilm-induced profiles of immune response gene expression by oral epithelial cells.	Ebersole JL, Peyyala R, Gonzalez OA.	Mol Oral Microbiol	10.1111/omi.12251	2019
Pathogenicity	Short-Time Antibacterial Effects of Dimethylaminododecyl Methacrylate on Oral Multispecies Biofilm In Vitro.	Zhou Y, Wang S, Zhou X, Zou Y, Li M, Peng X, Ren B, Xu HHK, Weir MD, Cheng L, Chen Y, Han Q.	Biomed Res Int	10.1155/2019/6393470	2019
	Host range, morphological and genomic characterisation of bacteriophages with activity against clinical Streptococcus agalactiae isolates.	Furfaro LL, Payne MS, Chang BJ.	PLoS One	10.1371/journal.pone.0235002	2020
	An experimental murine model to study periodontitis.	Marchesan J, Girnary MS, Jing L, Miao MZ, Zhang S, Sun L, Morelli T, Schoenfisch MH, Inohara N, Offenbacher S, Jiao Y.	Nat Protoc	10.1038/s41596-018-0035-4	2018
	Periodontal Application of Manuka Honey: Antimicrobial and Demineralising Effects In Vitro.	Safii SH, Tompkins GR, Duncan WJ.	Int J Dent	10.1155/2017/9874535	2017
Pathogenicity	A Bioengineered Nisin Derivative To Control Streptococcus uberis Biofilms.	Perez-Ibarreche M, Field D, Ross RP, Hill C.	Appl Environ Microbiol	10.1128/aem.00391-21	2021
	Inhibition of osteoclastogenesis by opsonized Porphyromonas gingivalis.	Pandruvada SN, Ebersole JL, Huja SS.	FASEB Bioadv	10.1096/fba.2018-00018	2019
	Microbial species associated with dental caries found in saliva and in situ after use of self-ligating and conventional brackets.	Bergamo AZN, Matsumoto MAN, Nascimento CD, Andrucioli MCD, Romano FL, Silva RAB, Silva LAB, Nelson-Filho P.	J Appl Oral Sci	10.1590/1678-7757-2018-0426	2019
Pathogenicity	Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability.	Hasegawa T, Takenaka S, Oda M, Domon H, Hiyoshi T, Sasagawa K, Ohsumi T, Hayashi N, Okamoto Y, Yamamoto H, Ohshima H, Terao Y, Noiri Y.	BMC Microbiol	10.1186/s12866-020-02033-w	2020
Metabolism	Effects of Complex DNA and MVs with GTF Extracted from Streptococcus mutans on the Oral Biofilm.	Senpuku H, Nakamura T, Iwabuchi Y, Hirayama S, Nakao R, Ohnishi M.	Molecules	10.3390/molecules24173131	2019
	Modulation of Neutrophil Extracellular Trap and Reactive Oxygen Species Release by Periodontal Bacteria.	Hirschfeld J, White PC, Milward MR, Cooper PR, Chapple ILC.	Infect Immun	10.1128/iai.00297-17	2017
Pathogenicity	Synergistic antibacterial effect between silibinin and antibiotics in oral bacteria.	Lee YS, Jang KA, Cha JD.	J Biomed Biotechnol	10.1155/2012/618081	2012
	Anti-Caries Effects of Dental Adhesives Containing Quaternary Ammonium Methacrylates with Different Chain Lengths.	Han Q, Li B, Zhou X, Ge Y, Wang S, Li M, Ren B, Wang H, Zhang K, Xu HHK, Peng X, Feng M, Weir MD, Chen Y, Cheng L.	Materials (Basel)	10.3390/ma10060643	2017
	A proposed mechanism for the interaction between the Candida albicans Als3 adhesin and streptococcal cell wall proteins.	Hoyer LL, Oh SH, Jones R, Cota E.	Front Microbiol	10.3389/fmicb.2014.00564	2014
	Antimicrobial Efficiency of Pistacia lentiscus L. Derivates against Oral Biofilm-Associated Diseases-A Narrative Review.	Milia EP, Sardellitti L, Eick S.	Microorganisms	10.3390/microorganisms11061378	2023
	In Vitro-Activity of Er:YAG Laser in Comparison with other Treatment Modalities on Biofilm Ablation from Implant and Tooth Surfaces.	Eick S, Meier I, Spoerle F, Bender P, Aoki A, Izumi Y, Salvi GE, Sculean A.	PLoS One	10.1371/journal.pone.0171086	2017
	Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair.	Wang B, Zhou L, Guo Y, Guo H, Zhong Y, Huang X, Ge Y, Wang Q, Chu X, Jin Y, Lan K, Yang M, Qu J.	Bioact Mater	10.1016/j.bioactmat.2021.10.032	2022
Enzymology	Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis.	Taudte N, Linnert M, Rahfeld JU, Piechotta A, Ramsbeck D, Buchholz M, Kolenko P, Parthier C, Houston JA, Veillard F, Eick S, Potempa J, Schilling S, Demuth HU, Stubbs MT.	J Biol Chem	10.1016/j.jbc.2021.100263	2021
	PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains.	Smiga M, Stepien P, Olczak M, Olczak T.	BMC Microbiol	10.1186/s12866-019-1511-x	2019
Pathogenicity	Oral epithelial cell responses to multispecies microbial biofilms.	Peyyala R, Kirakodu SS, Novak KF, Ebersole JL.	J Dent Res	10.1177/0022034512472508	2013
	Three-Dimensional In Vitro Oral Mucosa Models of Fungal and Bacterial Infections.	Tabatabaei F, Moharamzadeh K, Tayebi L.	Tissue Eng Part B Rev	10.1089/ten.teb.2020.0016	2020
Pathogenicity	Identification of Anion Channels Responsible for Fluoride Resistance in Oral Streptococci.	Men X, Shibata Y, Takeshita T, Yamashita Y.	PLoS One	10.1371/journal.pone.0165900	2016
	Metabolic Fingerprints from the Human Oral Microbiome Reveal a Vast Knowledge Gap of Secreted Small Peptidic Molecules.	Edlund A, Garg N, Mohimani H, Gurevich A, He X, Shi W, Dorrestein PC, McLean JS.	mSystems	10.1128/msystems.00058-17	2017
	Comprehensive Evaluation of the Biological Properties of Surface-Modified Titanium Alloy Implants.	Piszczek P, Radtke A, Ehlert M, Jedrzejewski T, Sznarkowska A, Sadowska B, Bartmanski M, Erdogan YK, Ercan B, Jedrzejczyk W.	J Clin Med	10.3390/jcm9020342	2020
Metabolism	Streptococcal H2O2 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death.	Okahashi N, Nakata M, Hirose Y, Morisaki H, Kataoka H, Kuwata H, Kawabata S.	PLoS One	10.1371/journal.pone.0231101	2020
Metabolism	Impact of Porphyromonas gingivalis Peptidylarginine Deiminase on Bacterial Biofilm Formation, Epithelial Cell Invasion, and Epithelial Cell Transcriptional Landscape.	Aliko A, Kaminska M, Bergum B, Gawron K, Benedyk M, Lamont RJ, Malicki S, Delaleu N, Potempa J, Mydel P.	Sci Rep	10.1038/s41598-018-32603-y	2018
	Ratiometric imaging of extracellular pH in bacterial biofilms with C-SNARF-4.	Schlafer S, Garcia JE, Greve M, Raarup MK, Nyvad B, Dige I.	Appl Environ Microbiol	10.1128/aem.02831-14	2015
	PgRsp Is a Novel Redox-Sensing Transcription Regulator Essential for Porphyromonas gingivalis Virulence.	Smiga M, Olczak T.	Microorganisms	10.3390/microorganisms7120623	2019
Metabolism	Epithelial interleukin-8 responses to oral bacterial biofilms.	Peyyala R, Kirakodu S, Novak KF, Ebersole JL.	Clin Vaccine Immunol	10.1128/cvi.05162-11	2011
Metabolism	Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits.	Bryzek D, Ciaston I, Dobosz E, Gasiorek A, Makarska A, Sarna M, Eick S, Puklo M, Lech M, Potempa B, Potempa J, Koziel J.	PLoS Pathog	10.1371/journal.ppat.1007773	2019
Pathogenicity	The oral commensal, Streptococcus gordonii, synergizes with Tat protein to induce HIV-1 promoter activation in monocytes/macrophages.	Gonzalez OA, Ebersole JL, Huang CB.	Cell Immunol	10.1016/j.cellimm.2011.03.008	2011
Pathogenicity	Antibacterial activity of dental composites containing zinc oxide nanoparticles.	Aydin Sevinc B, Hanley L.	J Biomed Mater Res B Appl Biomater	10.1002/jbm.b.31620	2010
Metabolism	Oral microbial biofilm stimulation of epithelial cell responses.	Peyyala R, Kirakodu SS, Novak KF, Ebersole JL.	Cytokine	10.1016/j.cyto.2011.12.016	2012
	A Biofilm Pocket Model to Evaluate Different Non-Surgical Periodontal Treatment Modalities in Terms of Biofilm Removal and Reformation, Surface Alterations and Attachment of Periodontal Ligament Fibroblasts.	Hagi TT, Klemensberger S, Bereiter R, Nietzsche S, Cosgarea R, Flury S, Lussi A, Sculean A, Eick S.	PLoS One	10.1371/journal.pone.0131056	2015
Pathogenicity	Antibacterial effects of blackberry extract target periodontopathogens.	Gonzalez OA, Escamilla C, Danaher RJ, Dai J, Ebersole JL, Mumper RJ, Miller CS.	J Periodontal Res	10.1111/j.1600-0765.2012.01506.x	2013
	Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms.	Huang CB, Alimova Y, Myers TM, Ebersole JL.	Arch Oral Biol	10.1016/j.archoralbio.2011.01.011	2011
	[Antibacterial activity of synthetic antimicrobial decapeptide against oral bacteria].	Yi L, Wei F, Lina W, Guangyan D, Hongkun W.	Hua Xi Kou Qiang Yi Xue Za Zhi	10.7518/hxkq.2014.06.017	2014
	Macrophage polarization in response to oral commensals and pathogens.	Huang CB, Alimova Y, Ebersole JL.	Pathog Dis	10.1093/femspd/ftw011	2016
Metabolism	Molecular interactions of surface protein peptides of Streptococcus gordonii with human salivary components.	Hamada T, Kawashima M, Watanabe H, Tagami J, Senpuku H.	Infect Immun	10.1128/iai.72.8.4819-4826.2004	2004
Metabolism	Diffusion of macromolecules in model oral biofilms.	Takenaka S, Pitts B, Trivedi HM, Stewart PS.	Appl Environ Microbiol	10.1128/aem.02279-08	2009
Metabolism	Novel model for multispecies biofilms that uses rigid gas-permeable lenses.	Peyyala R, Kirakodu SS, Ebersole JL, Novak KF.	Appl Environ Microbiol	10.1128/aem.00039-11	2011
	Subgingival microbiota in adult Down syndrome periodontitis.	Khocht A, Yaskell T, Janal M, Turner BF, Rams TE, Haffajee AD, Socransky SS.	J Periodontal Res	10.1111/j.1600-0765.2011.01459.x	2012
	Investigation of salivary function and oral microbiota of radiation caries-free people with nasopharyngeal carcinoma.	Zhang J, Liu H, Liang X, Zhang M, Wang R, Peng G, Li J.	PLoS One	10.1371/journal.pone.0123137	2015
Metabolism	Mutacins from Streptococcus mutans UA159 are active against multiple streptococcal species.	Hossain MS, Biswas I.	Appl Environ Microbiol	10.1128/aem.02320-10	2011
Phylogeny	Identification of clinically relevant viridans group streptococci to the species level by PCR.	Garnier F, Gerbaud G, Courvalin P, Galimand M.	J Clin Microbiol	10.1128/jcm.35.9.2337-2341.1997	1997
Metabolism	Effects of DNA methylation on expression of virulence genes in Streptococcus mutans.	Banas JA, Biswas S, Zhu M.	Appl Environ Microbiol	10.1128/aem.00543-11	2011
Pathogenicity	Antimicrobial penetration and efficacy in an in vitro oral biofilm model.	Corbin A, Pitts B, Parker A, Stewart PS.	Antimicrob Agents Chemother	10.1128/aac.00206-11	2011
Pathogenicity	Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology.	Guo L, McLean JS, Yang Y, Eckert R, Kaplan CW, Kyme P, Sheikh O, Varnum B, Lux R, Shi W, He X.	Proc Natl Acad Sci U S A	10.1073/pnas.1506207112	2015
Genetics	Bacteriocin (mutacin) production by Streptococcus mutans genome sequence reference strain UA159: elucidation of the antimicrobial repertoire by genetic dissection.	Hale JD, Ting YT, Jack RW, Tagg JR, Heng NC.	Appl Environ Microbiol	10.1128/aem.71.11.7613-7617.2005	2005
	Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model.	Soares GM, Teles F, Starr JR, Feres M, Patel M, Martin L, Teles R.	Antimicrob Agents Chemother	10.1128/aac.04974-14	2015
Pathogenicity	Direct visualization of spatial and temporal patterns of antimicrobial action within model oral biofilms.	Takenaka S, Trivedi HM, Corbin A, Pitts B, Stewart PS.	Appl Environ Microbiol	10.1128/aem.02218-07	2008
Metabolism	The Fusobacterium nucleatum outer membrane protein RadD is an arginine-inhibitable adhesin required for inter-species adherence and the structured architecture of multispecies biofilm.	Kaplan CW, Lux R, Haake SK, Shi W.	Mol Microbiol	10.1111/j.1365-2958.2008.06503.x	2009
	Cloning of the Streptococcus gordonii PK488 gene, encoding an adhesin which mediates coaggregation with Actinomyces naeslundii PK606.	Andersen RN, Ganeshkumar N, Kolenbrander PE.	Infect Immun	10.1128/iai.61.3.981-987.1993	1993
	An in vitro biofilm model of subgingival plaque.	Walker C, Sedlacek MJ.	Oral Microbiol Immunol	10.1111/j.1399-302x.2007.00336.x	2007
Enzymology	Purification, characterization, and molecular analysis of the gene encoding glucosyltransferase from Streptococcus oralis.	Fujiwara T, Hoshino T, Ooshima T, Sobue S, Hamada S.	Infect Immun	10.1128/iai.68.5.2475-2483.2000	2000
Metabolism	Comparative genomics and evolution of the amylase-binding proteins of oral streptococci.	Haase EM, Kou Y, Sabharwal A, Liao YC, Lan T, Lindqvist C, Scannapieco FA.	BMC Microbiol	10.1186/s12866-017-1005-7	2017
	Analysis of loci required for determination of serotype antigenicity in Streptococcus mutans and its clinical utilization.	Shibata Y, Ozaki K, Seki M, Kawato T, Tanaka H, Nakano Y, Yamashita Y.	J Clin Microbiol	10.1128/jcm.41.9.4107-4112.2003	2003
Phylogeny	Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains.	Nakano K, Nomura R, Shimizu N, Nakagawa I, Hamada S, Ooshima T.	J Clin Microbiol	10.1128/jcm.42.11.4925-4930.2004	2004
	Characterization of a Streptococcus sp.-Veillonella sp. community micromanipulated from dental plaque.	Chalmers NI, Palmer RJ, Cisar JO, Kolenbrander PE.	J Bacteriol	10.1128/jb.00983-08	2008
Metabolism	Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis.	Wegner N, Wait R, Sroka A, Eick S, Nguyen KA, Lundberg K, Kinloch A, Culshaw S, Potempa J, Venables PJ.	Arthritis Rheum	10.1002/art.27552	2010
Pathogenicity	Molecule Targeting Glucosyltransferase Inhibits Streptococcus mutans Biofilm Formation and Virulence.	Ren Z, Cui T, Zeng J, Chen L, Zhang W, Xu X, Cheng L, Li M, Li J, Zhou X, Li Y.	Antimicrob Agents Chemother	10.1128/aac.00919-15	2016
Pathogenicity	Molecular Assay for Detection of Genetic Markers Associated with Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae.	Peterson SW, Martin I, Demczuk W, Bharat A, Hoang L, Wylie J, Allen V, Lefebvre B, Tyrrell G, Horsman G, Haldane D, Garceau R, Wong T, Mulvey MR.	J Clin Microbiol	10.1128/jcm.00493-15	2015
Metabolism	Nucleotide sequence of the Streptococcus gordonii PK488 coaggregation adhesin gene, scaA, and ATP-binding cassette.	Kolenbrander PE, Andersen RN, Ganeshkumar N.	Infect Immun	10.1128/iai.62.10.4469-4480.1994	1994
	Transcriptional responses of Treponema denticola to other oral bacterial species.	Sarkar J, McHardy IH, Simanian EJ, Shi W, Lux R.	PLoS One	10.1371/journal.pone.0088361	2014
	Intrageneric coaggregation among strains of human oral bacteria: potential role in primary colonization of the tooth surface.	Kolenbrander PE, Andersen RN, Moore LV.	Appl Environ Microbiol	10.1128/aem.56.12.3890-3894.1990	1990
	Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.	Dhaliwal JS, Abd Rahman NA, Ming LC, Dhaliwal SKS, Knights J, Albuquerque Junior RF.	Front Cell Infect Microbiol	10.3389/fcimb.2021.736186	2021
Metabolism	The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.	Qi F, Chen P, Caufield PW.	Appl Environ Microbiol	10.1128/aem.67.1.15-21.2001	2001
	Mutacin production by Streptococcus mutans may promote transmission of bacteria from mother to child.	Gronroos L, Saarela M, Matto J, Tanner-Salo U, Vuorela A, Alaluusua S.	Infect Immun	10.1128/iai.66.6.2595-2600.1998	1998
	Anti-Planktonic and Anti-Biofilm Properties of Pentacyclic Triterpenes-Asiatic Acid and Ursolic Acid as Promising Antibacterial Future Pharmaceuticals.	Sycz Z, Tichaczek-Goska D, Wojnicz D.	Biomolecules	10.3390/biom12010098	2022
	Binding of salivary glycoprotein-secretory immunoglobulin A complex to the surface protein antigen of Streptococcus mutans.	Oho T, Yu H, Yamashita Y, Koga T.	Infect Immun	10.1128/iai.66.1.115-121.1998	1998
Enzymology	Particle size distribution of airborne microorganisms and pathogens during an Intense African dust event in the eastern Mediterranean.	Polymenakou PN, Mandalakis M, Stephanou EG, Tselepides A.	Environ Health Perspect	10.1289/ehp.10684	2008
	Identification of a 100-kilodalton putative coaggregation-mediating adhesin of Streptococcus gordonii DL1 (Challis).	Clemans DL, Kolenbrander PE.	Infect Immun	10.1128/iai.63.12.4890-4893.1995	1995
Enzymology	Detection of cariogenic Streptococcus mutans in extirpated heart valve and atheromatous plaque specimens.	Nakano K, Inaba H, Nomura R, Nemoto H, Takeda M, Yoshioka H, Matsue H, Takahashi T, Taniguchi K, Amano A, Ooshima T.	J Clin Microbiol	10.1128/jcm.00377-06	2006
	Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms.	Huang CB, George B, Ebersole JL.	Arch Oral Biol	10.1016/j.archoralbio.2010.05.009	2010
Enzymology	pH gradient and distribution of streptococci, lactobacilli, prevotellae, and fusobacteria in carious dentine.	Kianoush N, Nguyen KA, Browne GV, Simonian M, Hunter N.	Clin Oral Investig	10.1007/s00784-013-1009-0	2014
Metabolism	Regulation of bacteriocin production and cell death by the VicRK signaling system in Streptococcus mutans.	Senadheera DB, Cordova M, Ayala EA, Chavez de Paz LE, Singh K, Downey JS, Svensater G, Goodman SD, Cvitkovitch DG.	J Bacteriol	10.1128/jb.06071-11	2012
	Recognition of immunoglobulin A1 by oral actinomyces and streptococcal lectins.	Ruhl S, Sandberg AL, Cole MF, Cisar JO.	Infect Immun	10.1128/iai.64.12.5421-5424.1996	1996
Phylogeny	groESL sequence determination, phylogenetic analysis, and species differentiation for viridans group streptococci.	Teng LJ, Hsueh PR, Tsai JC, Chen PW, Hsu JC, Lai HC, Lee CN, Ho SW.	J Clin Microbiol	10.1128/jcm.40.9.3172-3178.2002	2002
Phylogeny	Molecular characterization of subject-specific oral microflora during initial colonization of enamel.	Diaz PI, Chalmers NI, Rickard AH, Kong C, Milburn CL, Palmer RJ, Kolenbrander PE.	Appl Environ Microbiol	10.1128/aem.72.4.2837-2848.2006	2006
	Differential expression of the Smb bacteriocin in Streptococcus mutans isolates.	Yonezawa H, Kuramitsu HK, Nakayama S, Mitobe J, Motegi M, Nakao R, Watanabe H, Senpuku H.	Antimicrob Agents Chemother	10.1128/aac.00235-08	2008
	Coaggregation of Streptococcus sanguis and other streptococci with Candida albicans.	Jenkinson HF, Lala HC, Shepherd MG.	Infect Immun	10.1128/iai.58.5.1429-1436.1990	1990
Metabolism	Coaggregation-mediated interactions of streptococci and actinomyces detected in initial human dental plaque.	Palmer RJ, Gordon SM, Cisar JO, Kolenbrander PE.	J Bacteriol	10.1128/jb.185.11.3400-3409.2003	2003
Pathogenicity	Genetic characterization of optochin-susceptible viridans group streptococci.	Martin-Galiano AJ, Balsalobre L, Fenoll A, de la Campa AG.	Antimicrob Agents Chemother	10.1128/aac.47.10.3187-3194.2003	2003
	Rapid identification of bacterial pathogens in positive blood culture bottles by use of a broad-based PCR assay coupled with high-resolution melt analysis.	Won H, Rothman R, Ramachandran P, Hsieh YH, Kecojevic A, Carroll KC, Aird D, Gaydos C, Yang S.	J Clin Microbiol	10.1128/jcm.00718-10	2010
	The vaginal microflora in relation to gingivitis.	Persson R, Hitti J, Verhelst R, Vaneechoutte M, Persson R, Hirschi R, Weibel M, Rothen M, Temmerman M, Paul K, Eschenbach D.	BMC Infect Dis	10.1186/1471-2334-9-6	2009
Phylogeny	Serotyping of Streptococcus pneumoniae based on capsular genes polymorphisms.	Raymond F, Boucher N, Allary R, Robitaille L, Lefebvre B, Tremblay C, Corbeil J, Gervaix A.	PLoS One	10.1371/journal.pone.0076197	2013
Metabolism	An extracelluar protease, SepM, generates functional competence-stimulating peptide in Streptococcus mutans UA159.	Hossain MS, Biswas I.	J Bacteriol	10.1128/jb.01381-12	2012
Enzymology	Identification of Abiotrophia adiacens and Abiotrophia defectiva by 16S rRNA gene PCR and restriction fragment length polymorphism analysis.	Ohara-Nemoto Y, Tajika S, Sasaki M, Kaneko M.	J Clin Microbiol	10.1128/jcm.35.10.2458-2463.1997	1997
Enzymology	Multiplex PCR assay for detection of Streptococcus suis species and serotypes 2 and 1/2 in tonsils of live and dead pigs.	Marois C, Bougeard S, Gottschalk M, Kobisch M.	J Clin Microbiol	10.1128/jcm.42.7.3169-3175.2004	2004
Metabolism	Insertional inactivation of genes responsible for the D-alanylation of lipoteichoic acid in Streptococcus gordonii DL1 (Challis) affects intrageneric coaggregations.	Clemans DL, Kolenbrander PE, Debabov DV, Zhang Q, Lunsford RD, Sakone H, Whittaker CJ, Heaton MP, Neuhaus FC.	Infect Immun	10.1128/iai.67.5.2464-2474.1999	1999
Metabolism	Mode of action of a lysostaphin-like bacteriolytic agent produced by Streptococcus zooepidemicus 4881.	Simmonds RS, Pearson L, Kennedy RC, Tagg JR.	Appl Environ Microbiol	10.1128/aem.62.12.4536-4541.1996	1996
	Streptococcus salivarius fimbriae are composed of a glycoprotein containing a repeated motif assembled into a filamentous nondissociable structure.	Levesque C, Vadeboncoeur C, Chandad F, Frenette M.	J Bacteriol	10.1128/jb.183.9.2724-2732.2001	2001
Metabolism	Delineation of a segment of adsorbed salivary acidic proline-rich proteins which promotes adhesion of Streptococcus gordonii to apatitic surfaces.	Gibbons RJ, Hay DI, Schlesinger DH.	Infect Immun	10.1128/iai.59.9.2948-2954.1991	1991
Phylogeny	Molecular identification of microorganisms from endodontic infections.	Rolph HJ, Lennon A, Riggio MP, Saunders WP, MacKenzie D, Coldero L, Bagg J.	J Clin Microbiol	10.1128/jcm.39.9.3282-3289.2001	2001
Phylogeny	Use of restriction fragment polymorphism analysis of rRNA genes to assign species to unknown clinical isolates of oral viridans streptococci.	Rudney JD, Larson CJ.	J Clin Microbiol	10.1128/jcm.32.2.437-443.1994	1994
	Detection of immunoglobulin A1 protease-induced Fab alpha fragments on dental plaque bacteria.	Ahl T, Reinholdt J.	Infect Immun	10.1128/iai.59.2.563-569.1991	1991
	Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge in mice.	Kawabata S, Kunitomo E, Terao Y, Nakagawa I, Kikuchi K, Totsuka K, Hamada S.	Infect Immun	10.1128/iai.69.2.924-930.2001	2001
Phylogeny	Subclass distribution of salivary secretory immunoglobulin A antibodies to oral streptococci.	Ahl T, Reinholdt J.	Infect Immun	10.1128/iai.59.10.3619-3625.1991	1991
Phylogeny	Species identification of oral viridans streptococci by restriction fragment polymorphism analysis of rRNA genes.	Rudney JD, Larson CJ.	J Clin Microbiol	10.1128/jcm.31.9.2467-2473.1993	1993
Enzymology	Distribution of proteins similar to IIIManH and IIIManL of the Streptococcus salivarius phosphoenolpyruvate:mannose-glucose phosphotransferase system among oral and nonoral bacteria.	Pelletier M, Frenette M, Vadeboncoeur C.	J Bacteriol	10.1128/jb.177.9.2270-2275.1995	1995
Metabolism	Regulation of bacteriocin production in Streptococcus mutans by the quorum-sensing system required for development of genetic competence.	van der Ploeg JR.	J Bacteriol	10.1128/jb.187.12.3980-3989.2005	2005
	Demonstration of human immunoglobulin G Fc-binding activity in oral bacteria.	Grenier D, Michaud J.	Clin Diagn Lab Immunol	10.1128/cdli.1.2.247-249.1994	1994
Phylogeny	Comparison of phenotypic characteristics, DNA-DNA hybridization results, and results with a commercial rapid biochemical and enzymatic reaction system for identification of viridans group streptococci.	Kikuchi K, Enari T, Totsuka K, Shimizu K.	J Clin Microbiol	10.1128/jcm.33.5.1215-1222.1995	1995
	Surface glycans of Candida albicans and other pathogenic fungi: physiological roles, clinical uses, and experimental challenges.	Masuoka J.	Clin Microbiol Rev	10.1128/cmr.17.2.281-310.2004	2004
Metabolism	Identification and characterization of a surface protein-releasing activity in Streptococcus mutans and other pathogenic streptococci.	Lee SF.	Infect Immun	10.1128/iai.60.10.4032-4039.1992	1992
	A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations.	Huang YJ, Kim E, Cox MJ, Brodie EL, Brown R, Wiener-Kronish JP, Lynch SV.	OMICS	10.1089/omi.2009.0100	2010
	Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma.	Zhou J, Hu Z, Wang L, Hu Q, Chen Z, Lin T, Zhou R, Cai Y, Wu Z, Zhang Z, Yang Y, Zhang C, Li G, Zeng L, Su K, Li H, Su Q, Zeng G, Cheng B, Wu T.	Microbiome	10.1186/s40168-024-01907-9	2024
Pathogenicity	Effective oral health in infective endocarditis: efficacy of high-street mouthwashes against the viridans group streptococci.	Elshibly A, Coulter WA, Millar BC, Prendergast BD, Thornhill M, Irwin C, Goldsmith CE, Moore JE.	J Investig Clin Dent	10.1111/jicd.12088	2014
Enzymology	Streptococcus mutans isolated from a 4-year-old girl diagnosed with infective endocarditis.	Kondo Y, Hoshino T, Ogawa M, Hidaka K, Hasuwa T, Moriuchi H, Fujiwara T.	Clin Exp Dent Res	10.1002/cre2.220	2019
Enzymology	LytF, a novel competence-regulated murein hydrolase in the genus Streptococcus.	Berg KH, Ohnstad HS, Havarstein LS.	J Bacteriol	10.1128/jb.06273-11	2012
Metabolism	Role of LytF and AtlS in eDNA release by Streptococcus gordonii.	Xu Y, Kreth J.	PLoS One	10.1371/journal.pone.0062339	2013
Phenotype	Biofilm viability checker: An open-source tool for automated biofilm viability analysis from confocal microscopy images.	Mountcastle SE, Vyas N, Villapun VM, Cox SC, Jabbari S, Sammons RL, Shelton RM, Walmsley AD, Kuehne SA.	NPJ Biofilms Microbiomes	10.1038/s41522-021-00214-7	2021
Genetics	Bacteriocin Producing Streptococcus agalactiae Strains Isolated from Bovine Mastitis in Brazil.	Vidal Amaral JR, Juca Ramos RT, Almeida Araujo F, Bentes Kato R, Figueira Aburjaile F, de Castro Soares S, Goes-Neto A, Matiuzzi da Costa M, Azevedo V, Brenig B, Soares de Oliveira S, Soares Rosado A.	Microorganisms	10.3390/microorganisms10030588	2022
Phylogeny	Use of quantitative PCR and culture methods to characterize ecological flux in bacterial biofilms.	Dalwai F, Spratt DA, Pratten J.	J Clin Microbiol	10.1128/jcm.01131-07	2007
Metabolism	Prevalence of the amylase-binding protein A gene (abpA) in oral streptococci.	Brown AE, Rogers JD, Haase EM, Zelasko PM, Scannapieco FA.	J Clin Microbiol	10.1128/jcm.37.12.4081-4085.1999	1999
Metabolism	Fratricide is essential for efficient gene transfer between pneumococci in biofilms.	Wei H, Havarstein LS.	Appl Environ Microbiol	10.1128/aem.01343-12	2012
Phylogeny	Streptococcus pseudopneumoniae identification by pherotype: a method to assist understanding of a potentially emerging or overlooked pathogen.	Leung MH, Ling CL, Ciesielczuk H, Lockwood J, Thurston S, Charalambous BM, Gillespie SH.	J Clin Microbiol	10.1128/jcm.00131-12	2012
Metabolism	Properties and biological role of streptococcal fratricins.	Berg KH, Biornstad TJ, Johnsborg O, Havarstein LS.	Appl Environ Microbiol	10.1128/aem.00098-12	2012
Metabolism	Role of Streptococcus gordonii amylase-binding protein A in adhesion to hydroxyapatite, starch metabolism, and biofilm formation.	Rogers JD, Palmer RJ, Kolenbrander PE, Scannapieco FA.	Infect Immun	10.1128/iai.69.11.7046-7056.2001	2001
Enzymology	Inhibition of the synthesis and secretion of extracellular glucosyl- and fructosyltransferase in Streptococcus sanguis by sodium ions.	Keevil CW, West AA, Bourne N, Marsh PD.	J Gen Microbiol	10.1099/00221287-130-1-77	1984
Phylogeny	Sequetyping: serotyping Streptococcus pneumoniae by a single PCR sequencing strategy.	Leung MH, Bryson K, Freystatter K, Pichon B, Edwards G, Charalambous BM, Gillespie SH.	J Clin Microbiol	10.1128/jcm.06384-11	2012
Phylogeny	Description and evaluation of the semiautomated 4-hour rapid ID 32 Strep method for identification of streptococci and members of related genera.	Freney J, Bland S, Etienne J, Desmonceaux M, Boeufgras JM, Fleurette J.	J Clin Microbiol	10.1128/jcm.30.10.2657-2661.1992	1992
Metabolism	Regulation of glucose metabolism in oral streptococci through independent pathways of glucose 6-phosphate and glucose 1-phosphate formation.	Keevil CW, Marsh PD, Ellwood DC.	J Bacteriol	10.1128/jb.157.2.560-567.1984	1984
Enzymology	Sialidase activity of the "Streptococcus milleri group" and other viridans group streptococci.	Beighton D, Whiley RA.	J Clin Microbiol	10.1128/jcm.28.6.1431-1433.1990	1990
	Sugar Substitute Stevia Inhibits Biofilm Formation, Exopolysaccharide Production, and Downregulates the Expression of Streptococcal Genes Involved in Exopolysaccharide Synthesis.	AlKanderi S, AlFreeh M, Bhardwaj RG, Karched M.	Dent J (Basel)	10.3390/dj11120267	2023
Enzymology	Real-time polymerase chain reaction quantification of the salivary levels of cariogenic bacteria in patients with orthodontic fixed appliances.	Al-Melh MA, Bhardwaj RG, Pauline EM, Karched M.	Clin Exp Dent Res	10.1002/cre2.285	2020
	The Effect of Benzyl Isothiocyanate on the Expression of Genes Encoding NADH Oxidase and Fibronectin-Binding Protein in Oral Streptococcal Biofilms.	Alhandal H, Almesaileikh E, Bhardwaj RG, Al Khabbaz A, Karched M.	Front Oral Health	10.3389/froh.2022.863723	2022
	Biofilm growth and IL-8 & TNF-alpha-inducing properties of Candida albicans in the presence of oral gram-positive and gram-negative bacteria.	Bhardwaj RG, Ellepolla A, Drobiova H, Karched M.	BMC Microbiol	10.1186/s12866-020-01834-3	2020
Metabolism	The oral commensal Streptococcus mitis activates the aryl hydrocarbon receptor in human oral epithelial cells.	Engen SA, Rorvik GH, Schreurs O, Blix IJ, Schenck K.	Int J Oral Sci	10.1038/ijos.2017.17	2017
	Bifacial biological effects of ethanol: acetaldehyde production by oral Streptococcus species and the antibacterial effects of ethanol against these bacteria.	Tagaino R, Washio J, Otani H, Sasaki K, Takahashi N.	J Oral Microbiol	10.1080/20002297.2021.1937884	2021
	Effects of Green Tea Extract Epigallocatechin-3-Gallate on Oral Diseases: A Narrative Review.	Li Y, Cheng L, Li M.	Pathogens	10.3390/pathogens13080634	2024
Metabolism	Aciduricity and acid tolerance mechanisms of Streptococcus anginosus.	Sasaki M, Kodama Y, Shimoyama Y, Ishikawa T, Kimura S	J Gen Appl Microbiol	10.2323/jgam.2017.11.005	2018
Pathogenicity	Antimicrobial Activity of a Colloidal AgNP Suspension Demonstrated In Vitro against Monoculture Biofilms: Toward a Novel Tooth Disinfectant for Treating Dental Caries.	Schwass DR, Lyons KM, Love R, Tompkins GR, Meledandri CJ	Adv Dent Res	10.1177/0022034517736495	2018
Phylogeny	Bacterial invasion into radicular dentine-an in vitro study.	Stauffacher S, Lussi A, Nietzsche S, Neuhaus KW, Eick S	Clin Oral Investig	10.1007/s00784-016-1960-7	2016
Pathogenicity	Intensity and duration of in-vitro antibacterial activity of different adhesives used in orthodontics.	Passariello C, Sannino G, Petti S, Gigola P	Eur J Oral Sci	10.1111/eos.12120	2014
Pathogenicity	Systematic screening of plant extracts from the Brazilian Pantanal with antimicrobial activity against bacteria with cariogenic relevance.	Brighenti FL, Salvador MJ, Delbem AC, Delbem AC, Oliveira MA, Soares CP, Freitas LS, Koga-Ito CY	Caries Res	10.1159/000357225	2014
Pathogenicity	Invasion of human aortic endothelial cells by oral viridans group streptococci and induction of inflammatory cytokine production.	Nagata E, de Toledo A, Oho T	Mol Oral Microbiol	10.1111/j.2041-1014.2010.00597.x	2010
Pathogenicity	Anaerobic killing of oral streptococci by reduced, transition metal cations.	Dunning JC, Ma Y, Marquis RE	Appl Environ Microbiol	10.1128/AEM.64.1.27-33.1998	1998
Genetics	Identification of the streptococcal competence-pheromone receptor.	Havarstein LS, Gaustad P, Nes IF, Morrison DA	Mol Microbiol	10.1046/j.1365-2958.1996.521416.x	1996
Genetics	Draft Genome Sequence of Streptococcus gordonii Type Strain CCUG 33482T.	Salva-Serra F, Jakobsson HE, Thorell K, Gonzales-Siles L, Hallback ET, Jaen-Luchoro D, Boulund F, Sikora P, Karlsson R, Svensson L, Bennasar A, Engstrand L, Kristiansson E, Moore ER	Genome Announc	10.1128/genomeA.00175-16	2016
Genetics	Draft Genome Sequence of Type Strain Streptococcus gordonii ATCC 10558.	Rasmussen LH, Dargis R, Christensen JJ, Skovgaard O, Nielsen XC	Genome Announc	10.1128/genomeA.01745-15	2016
Pathogenicity	In vitro evaluation of surface roughness, adhesion of periodontal ligament fibroblasts, and Streptococcus gordonii following root instrumentation with Gracey curettes and subsequent polishing with diamond-coated curettes.	Eick S, Bender P, Flury S, Lussi A, Sculean A	Clin Oral Investig	10.1007/s00784-012-0719-z	2012
Metabolism	Turning on and turning off the arginine deiminase system in oral streptococci.	Curran TM, Ma Y, Rutherford GC, Marquis RE	Can J Microbiol	10.1139/cjm-44-11-1078	1998

References

#2811	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 6777
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#42091	; Curators of the CIP;
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68381	Automatically annotated from API rID32STR .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#119711	Collection of Institut Pasteur ; Curators of the CIP; CIP 105258
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptococcus gordonii (DSM 6777, ATCC 10558, CIP 105258)

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