Streptococcus thermophilus (CCUG 21957, LMG 6896, CCTM 3104)

Name: Streptococcus thermophilus (CCUG 21957, LMG 6896, CCTM 3104)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 14786

Type strain

Strain Designation (B of R), B of R

Culture col. no. CCUG 21957 LMG 6896 CCTM 3104 DSM 20617 ATCC 19258 16 more

NCBI tax ID(s) 1091038 1308

Special Collections DSMZ CCUG JCM KCTC CIP

History <- NCDO <- P.M.F. Shattock, (B of R) NRIC 0256 <-- GIFU 8593 <-- NCDO 573 <-- A. T. R. Mattick <-- P. M. F. Shattock strain B of R. CIP <- 1986, NCFB <- Shattock: strain B of R

Links

Streptococcus thermophilus is a microaerophile, mesophilic, Gram-positive prokaryote that was isolated from pasteurized milk.

Gram-positive coccus-shaped microaerophile mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 92381

LMG 6896,ATCC 19258,CCUG 21957,DSM 20617,LMG 13102,NCFB 573,NCIMB 8510,NCTC 12958,NCDO 573,NCIB 8510,CIP 102303,CECT986,CCRC 13869,KCTC 3658,NCCB 97162,LMD 97.162,BCRC 13869,NBIMCC 3916,CNCTC 6717,VTT E-96665,JCM 17834

@ref 20215

Last LPSN update 2025-12-16 09:50:26

Domain Bacillati

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Streptococcaceae

Genus Streptococcus

Species Streptococcus thermophilus

Full scientific name Streptococcus thermophilus Orla-Jensen 1919 (Approved Lists 1980)

Synonyms (1)

Streptococcus salivarius subsp. thermophilus

BacDive ID	Other strains from **Streptococcus thermophilus** (8)	Type strain
14784	S. thermophilus 1, DSM 20259
14785	S. thermophilus LRA 094 11 78, A1, DSM 20479, NCDO 489, NCIB ...
134805	S. thermophilus TJ, CIP 67.57, NCDO 1611, NCDO 2564, CNRZ ...
136029	S. thermophilus CIP 102019
136971	S. thermophilus 1, CIP 66.31
137122	S. thermophilus CIP 67.56, NCDO 2563, CNRZ 21
138719	S. thermophilus 10, CIP 105446, ATCC 19987
162699	S. thermophilus JCM 20026, ATU L-20, IAM 1047

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
123510	positive	coccus-shaped
125438			91
125438	positive		92.519

Colony morphology

@ref	Incubation period	Hemolysis ability
8965	1-2 days
123510		1

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
8965	TODD-HEWITT MEDIUM (DSMZ Medium 697)	Medium recipe at MediaDive	Name: TODD-HEWITT MEDIUM (DSMZ Medium 697; with strain-specific modifications) Composition: Casein peptone 20.0 g/l Meat infusion 10.0 g/l NaCl 2.0 g/l NaHCO3 2.0 g/l Dextrose 2.0 g/l Choline 1.0 g/l Na2HPO4 0.4 g/l Distilled water
8965	MRS MEDIUM (DSMZ Medium 11)	Medium recipe at MediaDive	Name: MRS MEDIUM (DSMZ Medium 11) Composition: Glucose 20.0 g/l Casein peptone 10.0 g/l Meat extract 10.0 g/l Na-acetate 5.0 g/l Yeast extract 5.0 g/l (NH4)3 citrate 2.0 g/l K2HPO4 2.0 g/l Tween 80 1.0 g/l MgSO4 x 7 H2O 0.2 g/l MnSO4 x H2O 0.05 g/l Distilled water
8965	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
41772	MEDIUM 6 - Columbia agar with 10 % horse blood		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
123510	CIP Medium 6	Medium recipe at CIP
123510	CIP Medium 29	Medium recipe at CIP
123510	CIP Medium 72	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
8965	positive	growth	37	mesophilic
41772	positive	growth	37	mesophilic
47525	positive	growth	37-42
67770	positive	growth	37	mesophilic
123510	positive	growth	25-45
123510	negative	growth	10

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
8965	microaerophile
47525	aerobe
123510	facultative anaerobe
125439	microaerophile	97.9

Spore formation

@ref	Spore formation	Confidence
125438		92.42
125439		97.5

Halophily

@ref	Salt	Growth	Tested relation	Concentration
123510	NaCl		growth	6.5 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68381	40585 ChEBI	alpha-cyclodextrin	-	builds acid from	from API rID32STR
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68370	29016 ChEBI	arginine	-	hydrolysis	from API 20STR
68381	29016 ChEBI	arginine	-	hydrolysis	from API rID32STR
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68381	18333 ChEBI	D-arabitol	-	builds acid from	from API rID32STR
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68381	16899 ChEBI	D-mannitol	-	builds acid from	from API rID32STR
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68370	16899 ChEBI	D-mannitol	-	builds acid from	from API 20STR
68381	16988 ChEBI	D-ribose	-	builds acid from	from API rID32STR
68370	16988 ChEBI	D-ribose	-	builds acid from	from API 20STR
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68370	17924 ChEBI	D-sorbitol	-	builds acid from	from API 20STR
68381	16443 ChEBI	D-tagatose	-	builds acid from	from API rID32STR
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
123510	4853 ChEBI	esculin	-	hydrolysis
68370	4853 ChEBI	esculin	-	hydrolysis	from API 20STR
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68381	28087 ChEBI	glycogen	-	builds acid from	from API rID32STR
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68370	28087 ChEBI	glycogen	-	builds acid from	from API 20STR
68381	606565 ChEBI	hippurate	-	hydrolysis	from API rID32STR
123510	606565 ChEBI	hippurate	-	hydrolysis
68370	606565 ChEBI	hippurate	-	hydrolysis	from API 20STR
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68370	15443 ChEBI	inulin	-	builds acid from	from API 20STR
68381	30849 ChEBI	L-arabinose	-	builds acid from	from API rID32STR
68370	30849 ChEBI	L-arabinose	-	builds acid from	from API 20STR
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68381	17716 ChEBI	lactose	+	builds acid from	from API rID32STR
68370	17716 ChEBI	lactose	+	builds acid from	from API 20STR
68381	6731 ChEBI	melezitose	-	builds acid from	from API rID32STR
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68381	28053 ChEBI	melibiose	-	builds acid from	from API rID32STR
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68381	320055 ChEBI	methyl beta-D-glucopyranoside	-	builds acid from	from API rID32STR
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	-	builds acid from	from API 50CH acid
123510	17632 ChEBI	nitrate	-	reduction
123510	16301 ChEBI	nitrite	-	reduction
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68381	27941 ChEBI	pullulan	-	builds acid from	from API rID32STR
68381	16634 ChEBI	raffinose	-	builds acid from	from API rID32STR
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68370	16634 ChEBI	raffinose	-	builds acid from	from API 20STR
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68381	30911 ChEBI	sorbitol	-	builds acid from	from API rID32STR
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68370	28017 ChEBI	starch	-	builds acid from	from API 20STR
68381	17992 ChEBI	sucrose	+	builds acid from	from API rID32STR
68381	27082 ChEBI	trehalose	-	builds acid from	from API rID32STR
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68370	27082 ChEBI	trehalose	-	builds acid from	from API 20STR
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Antibiotic resistance

@ref	Metabolite	Is sensitive	Is resistant
123510	0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68370	15688 ChEBI	acetoin		from API 20STR
123510	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test
68370	15688 ChEBI	acetoin	+		from API 20STR
123510	15688 ChEBI	acetoin	+
123510	17234 ChEBI	glucose		+

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	-	3.1.3.2	from API zym
68381	Alanyl-Phenylalanyl-Proline arylamidase	+		from API rID32STR
123510	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68370	alkaline phosphatase	-	3.1.3.1	from API 20STR
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68381	alpha-galactosidase	-	3.2.1.22	from API rID32STR
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68370	alpha-galactosidase	-	3.2.1.22	from API 20STR
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68381	arginine dihydrolase	-	3.5.3.6	from API rID32STR
68370	arginine dihydrolase	-	3.5.3.6	from API 20STR
68381	beta-galactosidase	+	3.2.1.23	from API rID32STR
68382	beta-galactosidase	-	3.2.1.23	from API zym
123510	beta-galactosidase	+	3.2.1.23
68370	beta-galactosidase	+	3.2.1.23	from API 20STR
68381	beta-glucosidase	-	3.2.1.21	from API rID32STR
68382	beta-glucosidase	-	3.2.1.21	from API zym
68370	beta-glucosidase	-	3.2.1.21	from API 20STR
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68381	beta-glucuronidase	-	3.2.1.31	from API rID32STR
68370	beta-glucuronidase	-	3.2.1.31	from API 20STR
68381	beta-mannosidase	-	3.2.1.25	from API rID32STR
123510	catalase	-	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
8965	cytochrome-c oxidase	-	1.9.3.1
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
123510	gamma-glutamyltransferase	-	2.3.2.2
68382	leucine arylamidase	+	3.4.11.1	from API zym
68370	leucine arylamidase	+	3.4.11.1	from API 20STR
68382	lipase (C 14)	-		from API zym
123510	lysine decarboxylase	-	4.1.1.18
68381	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32STR
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	-		from API zym
123510	ornithine decarboxylase	-	4.1.1.17
123510	oxidase	-
68381	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32STR
68370	pyrrolidonyl arylamidase	-	3.4.19.3	from API 20STR
68382	trypsin	-	3.4.21.4	from API zym
123510	urease	+	3.5.1.5
68382	valine arylamidase	+		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
123510	-	-	+	+	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-

API 20STR

@ref	Acetoin production (Voges Proskauer test)VP	HIP	ESC	PYRA	alpha GAL	beta GUR	beta GAL	PAL	LAP	ADH	RIB	ARA	MAN	SOR	LAC	TRE	INU	RAF	AMD	GLYG	beta hemolysis presentbeta HEM
8965	+	-	-	-	-	-	+	-	+	-	-	-	-	-	+	-	-	-	-	-	-
8965	+	-	-	-	-	-	+	-	+	-	-	-	-	-	+	-	-	-	-	-	not determinedn.d.
8965	+	-	-	-	-	-	+	-	+	-	-	-	-	-	+	-	-	-	-	-	not determinedn.d.

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
8965	-	-	-	-	-	-	-	-	-	-	+	+/-	+/-	+/-	-	-	-	-	-	-	-	-	-	-	-	+/-	-	-	+/-	+/-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

API rID32STR

@ref	ADH (Arg)	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	TAG	beta MAN	URE
8965	-	-	+	-	-	+/-	-	-	-	+	-	-	+	-	-	-	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-
8965	-	-	+	-	-	+	-	-	-	+	-	-	+	-	-	-	+	+	+	-	-	+	-	-	-	+/-	-	-	-	-	-	+
8965	-	-	+	-	-	+/-	-	-	-	+	-	-	+	-	-	-	+	+	+	-	-	+/-	-	-	-	+	-	-	-	-	-	+
8965	-	-	+	-	-	-	-	-	-	+	-	-	+	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	+
8965	-	-	+	-	-	-	not determinedn.d.	-	-	+	-	-	+	-	-	-	+	+	+	-	-	+	-	-	-	+	-	-	-	-	-	+
8965	-	-	+	-	-	-	-	-	-	+	-	-	+	-	-	-	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-
8965	-	-	+	-	-	-	-	-	-	+	-	-	+	-	-	-	+	+	+	-	-	-	-	-	-	-	-	-	-	-	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Food production	#Dairy product
#Engineered	#Treatment	#Preserved
#Engineered	#Treatment	#Sterilized (Desinfected)

Isolation

@ref	Sample type
8965	pasteurized milk
47525	Pasteurized milk
67770	Heated and pasteurized milk
123510	Food, Pasteurized milk

Taxonmaps

69479

Global distribution of 16S sequence AY188354 (>99% sequence identity) for Streptococcus from Microbeatlas

Aquatic Samples	10320
Soil Samples	3877
Animal Samples	212872
Plant Samples	1738
Total Samples	228807

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
8965	1	Risk group (German classification) According to TRBA 466
123510	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1012059v1 assembly for Streptococcus thermophilus ATCC 19258	complete	GCA_010120595	1308.1093	8115039888	1308	97.6
124043	41965_C01 assembly for Streptococcus thermophilus NCTC12958	complete	GCA_900474985	1308.566		1308	94.86
66792	Streptococcus thermophilus strain DSM 20617	contig		1308.1597		1308	62.69
66792	Streptococcus thermophilus strain DSM 20617	contig		1308.1537		1308	62.69
66792	Streptococcus thermophilus strain DSM 20617	contig		1308.1561		1308	62.69
124043	ASM4264998v1 assembly for Streptococcus thermophilus CCUG 21957	scaffold	GCA_042649985			1308	61.03
66792	ASM1997287v1 assembly for Streptococcus thermophilus DSM 20617	contig	GCA_019972875	1308.1519	8115806410	1308	61.02
67770	ASM435450v1 assembly for Streptococcus thermophilus ATCC 19258	scaffold	GCA_004354505	1308.965		1308	59.03

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptococcus thermophilus strain DSM 20617 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer and tRNA-Ala gene, complete sequence; and 23S ribosomal RNA gene, partial sequence	DQ839563	529	1308
20218	Streptococcus thermophilus strain ATCC 19258 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA internal transcribed spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence	JN181393	538	1308
20218	S.thermophilus gene for 16S rRNA	X68418	1542	1308
8965	Streptococcus thermophilus strain ATCC 19258 16S ribosomal RNA gene, complete sequence	AY188354	1539	1308
124043	Streptococcus thermophilus partial 16S rRNA gene, strain CIP 102303	AM411115	195	1308
124043	Streptococcus thermophilus ATCC 19258 gene for 16S rRNA, partial sequence.	LC752342	588	1308
124043	Streptococcus thermophilus strain BCRC 13869 16S ribosomal RNA gene and 16S-23S ribosomal RNA intergenic spacer, partial sequence.	DQ204555	363	1308

GC content

@ref	GC-content (mol%)	Method
8965	39.6
67770	40	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Streptococcus thermophilus strain ATCC 19258
PATRIC: 1308.1093

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	97.50	no
125439	motility	BacteriaNetⓘ	no	77.50	no
125439	gram_stain	BacteriaNetⓘ	positive	69.80	no
125439	oxygen_tolerance	BacteriaNetⓘ	microaerophile	97.90	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptococcus thermophilus ATCC 19258
NCBI: GCA_010120595.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	92.52	no
125438	anaerobic	anaerobicⓘ	no	90.81	no
125438	aerobic	aerobicⓘ	no	97.27	no
125438	spore-forming	spore-formingⓘ	no	92.42	no
125438	thermophilic	thermophileⓘ	no	94.53	no
125438	flagellated	motile2+ⓘ	no	91.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Establishment and Validation of a Two-Step LAMP Assay for Detection of Bacillus cereus-Group Isolates in Food and Their Possibility of Non-haemolytic Enterotoxin Production.	Busch A, Schotte U, Jessberger N, Frentzel H, Plotz M, Abdulmawjood A.	Front Microbiol	10.3389/fmicb.2022.930648	2022
	Rapid Diagnostic of Streptococcus suis in Necropsy Samples of Pigs by thrA-Based Loop-Mediated Isothermal Amplification Assay.	Hess J, Kreitlow A, Rohn K, Hennig-Pauka I, Abdulmawjood A.	Microorganisms	10.3390/microorganisms11102447	2023
	Specificity of the AMP-6000 Method for Enumerating Clostridium Endospores in Milk.	Burtscher J, Rudavsky T, Zitz U, Domig KJ.	Foods	10.3390/foods13081192	2024
Phylogeny	Dynamics of whole and lysed bacterial cells during Parmigiano-Reggiano cheese production and ripening.	Gatti M, De Dea Lindner J, De Lorentiis A, Bottari B, Santarelli M, Bernini V, Neviani E.	Appl Environ Microbiol	10.1128/aem.00871-08	2008
	Substitution of Asp29 with Asn29 in the metallochaperone UreE of Streptococcus thermophilus DSM 20617^T increases the urease activity and anticipates urea hydrolysis during milk fermentation.	Arioli S, Mangieri N, Zanchetta Y, Russo P, Mora D.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2024.110684	2024
Genetics	RRNPP quorum-sensing repertoires in the salivarius group genomes: overrepresentation and synchronous activation of SHP/Rgg systems in Streptococcus thermophilus.	Caillot Q, Guillot A, Lacroix T, Oliveira-Correia L, Huillet E, Andre G, Nicolas P, Gardan R.	J Bacteriol	10.1128/jb.00231-25	2025
	The Effects of High-Dose Probiotic Supplementation on Immune Activation and Neurocognitive Disorders in People Living with HIV Undergoing Successful Antiretroviral Treatment: The Procog Study.	Vassallo M, Zerlini M, Fabre R, Joly H, Durant J, Makinson A, Mauries A, Capeau J, Fellahi S, Bastard JP, Pradier C, Lebrun-Frenay C.	Pathogens	10.3390/pathogens14060568	2025
	Effects of Probiotics, Prebiotics, and Synbiotics on Sarcopenia Parameters in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.	Besora-Moreno M, Llaurado E, Valls RM, Pedret A, Sola R.	Nutr Rev	10.1093/nutrit/nuae145	2025
Biotechnology	In vitro digestive system simulation and anticancer activity of soymilk fermented by probiotics and synbiotics immobilised on agro-industrial residues.	Gad AI, Orabi MM, Abou-Taleb KA, Abdelghani DY, Amin SA.	Sci Rep	10.1038/s41598-024-68086-3	2024
	Bacteriophage-host interactions in Streptococcus thermophilus and their impact on co-evolutionary processes.	Lavelle K, McDonnell B, Fitzgerald G, van Sinderen D, Mahony J.	FEMS Microbiol Rev	10.1093/femsre/fuad032	2023
	Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature.	Beltran-Velasco AI, Reiriz M, Uceda S, Echeverry-Alzate V.	Int J Mol Sci	10.3390/ijms25053010	2024
Pathogenicity	Long-term Probiotics Intervention Facilitates Recovery of Motor and Non-motor Functions by Regulating Inflammation and Modulating Gut-brain Axis in 6-OHDA Rat Model of Parkinson's Disease.	Sharma S, Jain S, Chittora R, Chaudhry R, Nag TC, A E, Radhakrishnan DM, Pandey S, Das S, Bamola VD, Kochhar KP.	Ann Neurosci	10.1177/09727531251335746	2025
	Effect of In Ovo Supplementation of Slab51 Probiotic Mixture, Associated with Marek's Disease Vaccine, on Growth Performance, Intestinal Morphology and Eimeria spp. Infection in Broiler Chickens.	Biagini L, Galosi L, Tambella AM, Roncarati A, De Bellis D, Pesaro S, Attili AR, Berardi S, Rossi G.	Animals (Basel)	10.3390/ani14233435	2024
Biotechnology	Manipulating the growth environment through co-culture to enhance stress tolerance and viability of probiotic strains in the gastrointestinal tract.	Oana K, Shimizu K, Takada T, Makino H, Yamazaki M, Katto M, Ando M, Kurakawa T, Oishi K.	Appl Environ Microbiol	10.1128/aem.01502-23	2023
	Viability-PCR for the selective detection of Lactobacillus acidophilus and Bifidobacterium bifidum in live bacteria-containing products.	Catone S, Iannantuono S, Genovese D, Von Hunolstein C, Franciosa G.	Front Microbiol	10.3389/fmicb.2024.1400529	2024
Metabolism	Probiotics as Potential Tool to Mitigate Nucleotide Metabolism Alterations Induced by DiNP Dietary Exposure in Danio rerio.	Giommi C, Maradonna F, Ladisa C, Habibi HR, Carnevali O.	Int J Mol Sci	10.3390/ijms252011151	2024
	Clove and Thyme Essential Oils: From Molecular Docking to Food Application-A Study of Their Preservative Properties in Buttermilk.	Atteya MR, Romeilah RM, Ramadan KMA, El-Beltagi HS, Gaber AM, Al Hashedi SA, AboZaid NA, Mahmoud MAA, Youssef R, Mohamed RA, Bendary ESA.	ACS Omega	10.1021/acsomega.4c11538	2025
	Bifidobacterium infantis and Bifidobacterium breve Improve Symptomatology and Neuronal Damage in Neurodegenerative Disease: A Systematic Review.	Reiriz M, Beltran-Velasco AI, Echeverry-Alzate V, Martinez-Miguel E, Gomez-Senent S, Uceda S, Clemente-Suarez VJ.	Nutrients	10.3390/nu17030391	2025
	Probiotics and Functional Gastrointestinal Disorders in Pediatric Age: A Narrative Review.	Capozza M, Laforgia N, Rizzo V, Salvatore S, Guandalini S, Baldassarre M.	Front Pediatr	10.3389/fped.2022.805466	2022
	Efficacy of probiotic Streptococcus thermophilus in counteracting TGF-beta1-induced fibrotic response in normal human dermal fibroblasts.	Lombardi F, Augello FR, Artone S, Bahiti B, Sheldon JM, Giuliani M, Cifone MG, Palumbo P, Cinque B.	J Inflamm (Lond)	10.1186/s12950-022-00324-9	2022
	Looking for the Ideal Probiotic Healing Regime.	Menni A, Moysidis M, Tzikos G, Stavrou G, Tsetis JK, Shrewsbury AD, Filidou E, Kotzampassi K.	Nutrients	10.3390/nu15133055	2023
Pathogenicity	Promysalin is a salicylate-containing antimicrobial with a cell-membrane-disrupting mechanism of action on Gram-positive bacteria.	Kaduskar RD, Scala GD, Al Jabri ZJH, Arioli S, Musso L, Oggioni MR, Dallavalle S, Mora D.	Sci Rep	10.1038/s41598-017-07567-0	2017
	Bacterial Lysate from the Multi-Strain Probiotic SLAB51 Triggers Adaptative Responses to Hypoxia in Human Caco-2 Intestinal Epithelial Cells under Normoxic Conditions and Attenuates LPS-Induced Inflammatory Response.	Lombardi F, Augello FR, Palumbo P, Bonfili L, Artone S, Altamura S, Sheldon JM, Latella G, Cifone MG, Eleuteri AM, Cinque B.	Int J Mol Sci	10.3390/ijms24098134	2023
Metabolism	Strategic Modification of Gut Microbiota through Oral Bacteriotherapy Influences Hypoxia Inducible Factor-1alpha: Therapeutic Implication in Alzheimer's Disease.	Bonfili L, Gong C, Lombardi F, Cifone MG, Eleuteri AM.	Int J Mol Sci	10.3390/ijms23010357	2021
	rBet v 1 immunotherapy of sensitized mice with Streptococcus thermophilus as vehicle and adjuvant.	Petrarca C, Clemente E, Toto V, Iezzi M, Rossi C, Zanotta S, Mistrello G, Zanoni I, Granucci F, Arioli S, Mora D, Guglielmetti S, Paganelli R, Di Gioacchino M.	Hum Vaccin Immunother	10.4161/hv.28155	2014
Enzymology	Screening and characterization of soil bacteria for lignin and textile dye effluent bioremediation and optimization using response surface methodology.	Milad S, Saleh SE, Aboulwafa MM, Hassouna NA.	Sci Rep	10.1038/s41598-025-04789-5	2025
	Human microbiome in post-acute COVID-19 syndrome (PACS).	Fallah A, Sedighian H, Kachuei R, Fooladi AAI.	Curr Res Microb Sci	10.1016/j.crmicr.2024.100324	2025
Pathogenicity	CRISPR spacers acquired from plasmids primarily target backbone genes, making them valuable for predicting potential hosts and host range.	Androsiuk L, Maane S, Tal S.	Microbiol Spectr	10.1128/spectrum.00104-24	2024
Genetics	Genome Analysis and Physiological Characterization of Four Streptococcus thermophilus Strains Isolated From Chinese Traditional Fermented Milk.	Hu T, Cui Y, Zhang Y, Qu X, Zhao C.	Front Microbiol	10.3389/fmicb.2020.00184	2020
	Soluble Fraction from Lysate of a High Concentration Multi-Strain Probiotic Formulation Inhibits TGF-beta1-Induced Intestinal Fibrosis on CCD-18Co Cells.	Lombardi F, Augello FR, Palumbo P, Mollsi E, Giuliani M, Cimini AM, Cifone MG, Cinque B.	Nutrients	10.3390/nu13030882	2021
Pathogenicity	Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction.	Zheng Y, Zhang L, Bonfili L, de Vivo L, Eleuteri AM, Bellesi M.	Nutrients	10.3390/nu15061518	2023
	Oxygen Sparing Effect of Bacteriotherapy in COVID-19.	Ceccarelli G, Marazzato M, Celani L, Lombardi F, Piccirilli A, Mancone M, Trinchieri V, Pugliese F, Mastroianni CM, d'Ettorre G.	Nutrients	10.3390/nu13082898	2021
Phylogeny	Isolation of bacteria from artificial bronchoalveolar lavage fluid using density gradient centrifugation and their accessibility by Raman spectroscopy.	Wichmann C, Rosch P, Popp J.	Anal Bioanal Chem	10.1007/s00216-021-03488-0	2021
	Oral Bacteriotherapy in Patients With COVID-19: A Retrospective Cohort Study.	Ceccarelli G, Borrazzo C, Pinacchio C, Santinelli L, Innocenti GP, Cavallari EN, Celani L, Marazzato M, Alessandri F, Ruberto F, Pugliese F, Venditti M, Mastroianni CM, d'Ettorre G.	Front Nutr	10.3389/fnut.2020.613928	2020
	Clinical effectiveness of adding probiotics to a low FODMAP diet: Randomized double-blind placebo-controlled study.	Turan B, Bengi G, Cehreli R, Akpinar H, Soyturk M.	World J Clin Cases	10.12998/wjcc.v9.i25.7417	2021
	Factors Associated With Short-Term Eradication of Rectal Colonization by KPC-2 Producing Klebsiella pneumoniae in an Outbreak Setting.	Pellice M, Rodriguez-Nunez O, Rico V, Aguero D, Morata L, Cardozo C, Puerta-Alcalde P, Garcia-Vidal C, Rubio E, Fernandez-Pittol MJ, Vergara A, Pitart C, Marco F, Santana G, Rodriguez-Serna L, Vilella A, Lopez E, Soriano A, Martinez JA, Del Rio A.	Front Microbiol	10.3389/fmicb.2021.630826	2021
Phylogeny	Characterization of Silver Carbonate Nanoparticles Biosynthesized Using Marine Actinobacteria and Exploring of Their Antimicrobial and Antibiofilm Activity.	Messaoudi O, Benamar I, Azizi A, Albukhaty S, Khane Y, Sulaiman GM, Salem-Bekhit MM, Hamdi K, Ghoummid S, Zoukel A, Messahli I, Kerchich Y, Benaceur F, Salem MM, Bendahou M.	Mar Drugs	10.3390/md21100536	2023
	Impact of inulin and yeast containing synbiotic on calves' productivity and greenhouse gas production.	Jonova S, Ilgaza A, Zolovs M, Balins A.	Vet World	10.14202/vetworld.2020.1017-1024	2020
	Potential Role of Probiotics for Inflammaging: A Narrative Review.	Jukic Peladic N, Dell'Aquila G, Carrieri B, Maggio M, Cherubini A, Orlandoni P.	Nutrients	10.3390/nu13092919	2021
	Innovative Fermented Beverages Made with Red Rice, Barley, and Buckwheat.	Cardinali F, Osimani A, Milanovic V, Garofalo C, Aquilanti L.	Foods	10.3390/foods10030613	2021
Metabolism	Type I/II Interferon in HIV-1-Infected Patients: Expression in Gut Mucosa and in Peripheral Blood Mononuclear Cells and Its Modification upon Probiotic Supplementation.	Pinacchio C, Scheri GC, Statzu M, Santinelli L, Ceccarelli G, Innocenti GP, Vullo V, Antonelli G, Brenchley JM, d'Ettorre G, Scagnolari C.	J Immunol Res	10.1155/2018/1738676	2018
	Can Probiotics, Particularly Limosilactobacillus fermentum UCO-979C and Lacticaseibacillus rhamnosus UCO-25A, Be Preventive Alternatives against SARS-CoV-2?	Valdebenito-Navarrete H, Fuentes-Barrera V, Smith CT, Salas-Burgos A, Zuniga FA, Gomez LA, Garcia-Cancino A.	Biology (Basel)	10.3390/biology12030384	2023
	The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)-A Critical Review.	Jakubczyk D, Leszczynska K, Gorska S.	Nutrients	10.3390/nu12071973	2020
	Quality of Life: Psychological Symptoms-Effects of a 2-Month Healthy Diet and Nutraceutical Intervention; A Randomized, Open-Label Intervention Trial (RISTOMED).	Bourdel-Marchasson I, Ostan R, Regueme SC, Pinto A, Pryen F, Charrouf Z, d'Alessio P, Baudron CR, Guerville F, Durrieu J, Donini LM, Franceschi C, Valentini L.	Nutrients	10.3390/nu12030800	2020
Metabolism	Aspartate biosynthesis is essential for the growth of Streptococcus thermophilus in milk, and aspartate availability modulates the level of urease activity.	Arioli S, Monnet C, Guglielmetti S, Parini C, De Noni I, Hogenboom J, Halami PM, Mora D.	Appl Environ Microbiol	10.1128/aem.00533-07	2007
	Effectiveness and Safety of a Probiotic-Mixture for the Treatment of Infantile Colic: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial with Fecal Real-Time PCR and NMR-Based Metabolomics Analysis.	Baldassarre ME, Di Mauro A, Tafuri S, Rizzo V, Gallone MS, Mastromarino P, Capobianco D, Laghi L, Zhu C, Capozza M, Laforgia N.	Nutrients	10.3390/nu10020195	2018
	The immune response modulated by inoculation of commensal bacteria at birth impacts the gut microbiota and prevents Salmonella colonization.	Kempf F, Drumo R, Chausse AM, Menanteau P, Kubasova T, Roche S, Lalmanach AC, Guabiraba R, Chaumeil T, Lariviere-Gauthier G, Caballero-Posadas I, Laroche B, Rychlik I, Virlogeux-Payant I, Velge P.	Gut Microbes	10.1080/19490976.2025.2474151	2025
Pathogenicity	The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment.	Wang M, Zhang Y, Li C, Chang W, Zhang L.	Front Immunol	10.3389/fimmu.2023.1180336	2023
Enzymology	Evaluation of culture media for selective enumeration of bifidobacteria and lactic acid bacteria.	Sule J, Korosi T, Hucker A, Varga L.	Braz J Microbiol	10.1590/s1517-83822014000300035	2014
	Administration of a Multi-Strain Probiotic Product to Women in the Perinatal Period Differentially Affects the Breast Milk Cytokine Profile and May Have Beneficial Effects on Neonatal Gastrointestinal Functional Symptoms. A Randomized Clinical Trial.	Baldassarre ME, Di Mauro A, Mastromarino P, Fanelli M, Martinelli D, Urbano F, Capobianco D, Laforgia N.	Nutrients	10.3390/nu8110677	2016
Metabolism	Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches.	Gioacchini G, Rossi G, Carnevali O.	Sci Rep	10.1038/s41598-017-01322-1	2017
	Probiotic supplementation in trained trotter horses: effect on blood clinical pathology data and urine metabolomic assessed in field.	Laghi L, Zhu C, Campagna G, Rossi G, Bazzano M, Laus F.	J Appl Physiol (1985)	10.1152/japplphysiol.01131.2017	2018
	Viral Abundance and Diversity of Production Fluids in Oil Reservoirs.	Zheng L, Liang X, Shi R, Li P, Zhao J, Li G, Wang S, Han S, Radosevich M, Zhang Y.	Microorganisms	10.3390/microorganisms8091429	2020
	High potency multistrain probiotic improves liver histology in non-alcoholic fatty liver disease (NAFLD): a randomised, double-blind, proof of concept study.	Duseja A, Acharya SK, Mehta M, Chhabra S, Shalimar, Rana S, Das A, Dattagupta S, Dhiman RK, Chawla YK.	BMJ Open Gastroenterol	10.1136/bmjgast-2019-000315	2019
Pathogenicity	Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide.	Wendler J, Schroeder BO, Ehmann D, Koeninger L, Mailander-Sanchez D, Lemberg C, Wanner S, Schaller M, Stange EF, Malek NP, Weidenmaier C, LeibundGut-Landmann S, Wehkamp J.	Sci Rep	10.1038/s41598-019-40216-2	2019
	Probiotics Differently Affect Gut-Associated Lymphoid Tissue Indolamine-2,3-Dioxygenase mRNA and Cerebrospinal Fluid Neopterin Levels in Antiretroviral-Treated HIV-1 Infected Patients: A Pilot Study.	Scagnolari C, Corano Scheri G, Selvaggi C, Schietroma I, Najafi Fard S, Mastrangelo A, Giustini N, Serafino S, Pinacchio C, Pavone P, Fanello G, Ceccarelli G, Vullo V, d'Ettorre G.	Int J Mol Sci	10.3390/ijms17101639	2016
Pathogenicity	A pilot study on the effects of probiotic supplementation on neuropsychological performance and microRNA-29a-c levels in antiretroviral-treated HIV-1-infected patients.	Ceccarelli G, Fratino M, Selvaggi C, Giustini N, Serafino S, Schietroma I, Corano Scheri G, Pavone P, Passavanti G, Alunni Fegatelli D, Mezzaroma I, Antonelli G, Vullo V, Scagnolari C, d'Ettorre G.	Brain Behav	10.1002/brb3.756	2017
	The Impact of Low-FODMAPs, Gluten-Free, and Ketogenic Diets on Gut Microbiota Modulation in Pathological Conditions.	Reddel S, Putignani L, Del Chierico F.	Nutrients	10.3390/nu11020373	2019
Genetics	Identification of the Biosynthetic Gene Cluster of Thermoactinoamides and Discovery of New Congeners by Integrated Genome Mining and MS-Based Molecular Networking.	Della Sala G, Mangoni A, Costantino V, Teta R.	Front Chem	10.3389/fchem.2020.00397	2020
	Kefir Supplementation Modifies Gut Microbiota Composition, Reduces Physical Fatigue, and Improves Exercise Performance in Mice.	Hsu YJ, Huang WC, Lin JS, Chen YM, Ho ST, Huang CC, Tung YT.	Nutrients	10.3390/nu10070862	2018
	Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals.	Ceccarelli G, Brenchley JM, Cavallari EN, Scheri GC, Fratino M, Pinacchio C, Schietroma I, Fard SN, Scagnolari C, Mezzaroma I, Vullo V, d'Ettorre G.	Nutrients	10.3390/nu9111269	2017
	Production Conditions Affect the In Vitro Anti-Tumoral Effects of a High Concentration Multi-Strain Probiotic Preparation.	Cinque B, La Torre C, Lombardi F, Palumbo P, Van der Rest M, Cifone MG.	PLoS One	10.1371/journal.pone.0163216	2016
	Effect of probiotic treatment on the clinical course, intestinal microbiome, and toxigenic Clostridium perfringens in dogs with acute hemorrhagic diarrhea.	Ziese AL, Suchodolski JS, Hartmann K, Busch K, Anderson A, Sarwar F, Sindern N, Unterer S.	PLoS One	10.1371/journal.pone.0204691	2018
	The Utilisation of Acrylamide by Selected Microorganisms Used for Fermentation of Food.	Petka K, Wajda L, Duda-Chodak A.	Toxics	10.3390/toxics9110295	2021
	Effects of probiotics (Vivomixx®) in obese pregnant women and their newborn: study protocol for a randomized controlled trial.	Halkjaer SI, Nilas L, Carlsen EM, Cortes D, Halldorsson TI, Olsen SF, Pedersen AE, Krogfelt KA, Petersen AM.	Trials	10.1186/s13063-016-1617-5	2016
	Formation and Characterization of Early Bacterial Biofilms on Different Wood Typologies Applied in Dairy Production.	Cruciata M, Gaglio R, Scatassa ML, Sala G, Cardamone C, Palmeri M, Moschetti G, La Mantia T, Settanni L.	Appl Environ Microbiol	10.1128/aem.02107-17	2018
Metabolism	A Review on Role of Microbiome in Obesity and Antiobesity Properties of Probiotic Supplements.	Sivamaruthi BS, Kesika P, Suganthy N, Chaiyasut C.	Biomed Res Int	10.1155/2019/3291367	2019
	The emerging role of probiotics as a mitigation strategy against coronavirus disease 2019 (COVID-19).	Mirzaei R, Attar A, Papizadeh S, Jeda AS, Hosseini-Fard SR, Hosseini-Fard SR, Jamasbi E, Kazemi S, Amerkani S, Talei GR, Moradi P, Jalalifar S, Yousefimashouf R, Hossain MA, Keyvani H, Karampoor S.	Arch Virol	10.1007/s00705-021-05036-8	2021
Pathogenicity	Manipulation of Gut Microbiota Influences Immune Responses, Axon Preservation, and Motor Disability in a Model of Progressive Multiple Sclerosis.	Mestre L, Carrillo-Salinas FJ, Mecha M, Feliu A, Espejo C, Alvarez-Cermeno JC, Villar LM, Guaza C.	Front Immunol	10.3389/fimmu.2019.01374	2019
	Autism Spectrum Disorders and the Gut Microbiota.	Fattorusso A, Di Genova L, Dell'Isola GB, Mencaroni E, Esposito S.	Nutrients	10.3390/nu11030521	2019
	Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease.	White R, Atherly T, Guard B, Rossi G, Wang C, Mosher C, Webb C, Hill S, Ackermann M, Sciabarra P, Allenspach K, Suchodolski J, Jergens AE.	Gut Microbes	10.1080/19490976.2017.1334754	2017
Phylogeny	[A molecular biology approach to the species identification of coagulase-negative staphylococci].	Akatova EA, Schumacher-Perdreau F, Pulverer G.	Zh Mikrobiol Epidemiol Immunobiol		1993
Enzymology	A DNA-probe for the detection of the species Staphylococcus haemolyticus.	Akatova E, Schumacher-Perdreau F, Pulverer G.	FEMS Microbiol Lett	10.1016/0378-1097(92)90495-a	1992
	Enhancement of disease resistance, growth potential, and photosynthesis in tomato (Solanum lycopersicum) by inoculation with an endophytic actinobacterium, Streptomyces thermocarboxydus strain BPSAC147.	Passari AK, Upadhyaya K, Singh G, Abdel-Azeem AM, Thankappan S, Uthandi S, Hashem A, Abd Allah EF, Malik JA, As A, Gupta VK, Ranjan S, Singh BP.	PLoS One	10.1371/journal.pone.0219014	2019
Metabolism	Cholesterol assimilation by lactic acid bacteria and bifidobacteria isolated from the human gut.	Pereira DI, Gibson GR.	Appl Environ Microbiol	10.1128/aem.68.9.4689-4693.2002	2002
	Gut microbiota and old age: Modulating factors and interventions for healthy longevity.	Coman V, Vodnar DC.	Exp Gerontol	10.1016/j.exger.2020.111095	2020
Pathogenicity	Synergistic effect of membrane-active peptides polymyxin B and gramicidin S on multidrug-resistant strains and biofilms of Pseudomonas aeruginosa.	Berditsch M, Jager T, Strempel N, Schwartz T, Overhage J, Ulrich AS.	Antimicrob Agents Chemother	10.1128/aac.00682-15	2015
	A novel real-time PCR assay for specific detection and quantification of Mycobacterium avium subsp. paratuberculosis in milk with the inherent possibility of differentiation between viable and dead cells.	Dzieciol M, Volgger P, Khol J, Baumgartner W, Wagner M, Hein I.	BMC Res Notes	10.1186/1756-0500-3-251	2010
Phenotype	Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters.	Santocchi E, Guiducci L, Fulceri F, Billeci L, Buzzigoli E, Apicella F, Calderoni S, Grossi E, Morales MA, Muratori F.	BMC Psychiatry	10.1186/s12888-016-0887-5	2016
	Early-Life Immune System Maturation in Chickens Using a Synthetic Community of Cultured Gut Bacteria.	Zenner C, Hitch TCA, Riedel T, Wortmann E, Tiede S, Buhl EM, Abt B, Neuhaus K, Velge P, Overmann J, Kaspers B, Clavel T.	mSystems	10.1128/msystems.01300-20	2021
	A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations.	Huang YJ, Kim E, Cox MJ, Brodie EL, Brown R, Wiener-Kronish JP, Lynch SV.	OMICS	10.1089/omi.2009.0100	2010
	Construction and optimization of a nisin-controlled expression vector using a pre-screened strong promoter in Streptococcus thermophilus.	Ye Y, Zhao R, Li L, Li Z, Chen Y, Xu Z.	Front Microbiol	10.3389/fmicb.2025.1586348	2025
	The impact of Streptococcus thermophilus IDCC 2201 on gut microbiota and its potential as a prophylactic agent for colorectal cancer.	Nam EH, Lee M, Kim H, Kim D, Lee Y, Jung YH, Yang J, Shin M.	Sci Rep	10.1038/s41598-025-20976-w	2025
	Thermophilin 13: In Silico Analysis Provides New Insight in Genes Involved in Bacteriocin Production.	Salini F, Iacumin L, Comi G, Dicks LMT.	Microorganisms	10.3390/microorganisms11030611	2023
	New Genetic Determinants for qPCR Identification and the Enumeration of Selected Lactic Acid Bacteria in Raw-Milk Cheese.	Stachelska MA, Ekielski A, Karpinski P, Zelazinski T, Kruszewski B.	Molecules	10.3390/molecules29071533	2024
	Synergistic antibacterial effects of postbiotics combined with linezolid and amikacin against nosocomial pathogens.	Yaprak Colak E, Duran N.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1616501	2025
	Emerging Roles of the Gut Microbiome in Musculoskeletal Injury and Repair.	Roberts JL, Park CC.	Microorganisms	10.3390/microorganisms13092193	2025
	PMA-qPCR method for the selective quantitation of viable lactic acid bacteria in fermented milk.	Shi Z, Li X, Fan X, Xu J, Liu Q, Wu Z, Pan D.	Front Microbiol	10.3389/fmicb.2022.984506	2022
Pathogenicity	Exploring the Potential of Novel Animal-Origin Probiotics as Key Players in One Health: Opportunities and Challenges.	Gorzelanna Z, Mamrot A, Bedkowska D, Bubak J, Miszczak M.	Int J Mol Sci	10.3390/ijms26115143	2025
	Developing Bioactive Hydrogels with Peptides for Dental Application.	Muntean A, Sarosi C, Petean I, Cuc S, Carpa R, Chis IA, Ilea A, Delean AG, Moldovan M.	Biomedicines	10.3390/biomedicines12030694	2024
	Development of optimized functional clove fortified probiotic yoghurt.	Saleena LAK, Song AA, Yusof YA, In LLA, Lin NK, Pui LP.	J Food Sci Technol	10.1007/s13197-023-05904-y	2024
	Gene expression dynamics in Bacillus cereus and Bacillus subtilis treated with Thymus vulgaris and Origanum vulgare subsp. hirtum essential oils.	Anniballi F, Purgatorio C, Serio A, Scalfaro C, Taglieri S, Paparella A.	Front Microbiol	10.3389/fmicb.2025.1643608	2025
	A novel SUCNR1 inhibitor alleviates dysbiosis through inhibition of host responses without direct interaction with host microbiota.	Thomas SC, Guo Y, Xu F, Saxena D, Li X.	Mol Oral Microbiol	10.1111/omi.12431	2024
	Antimicrobial activities of Asian plant extracts against pathogenic and spoilage bacteria.	Han A, Hwang JH, Lee SY.	Food Sci Biotechnol	10.1007/s10068-022-01182-0	2023
	Quantitative real-time PCR analysis of bacterial biomarkers enable fast and accurate monitoring in inflammatory bowel disease.	Sezgin E, Terlemez G, Bozkurt B, Bengi G, Akpinar H, Buyuktorun I.	PeerJ	10.7717/peerj.14217	2022
Biotechnology	Genome-Scale Metabolic Modeling Combined with Transcriptome Profiling Provides Mechanistic Understanding of Streptococcus thermophilus CH8 Metabolism.	Rau MH, Gaspar P, Jensen ML, Geppel A, Neves AR, Zeidan AA.	Appl Environ Microbiol	10.1128/aem.00780-22	2022
	An overview of probiotic camel milk as a nutritional beverage: Challenges and perspectives.	Ansari F, Pourjafar H, Samakkhah SA, Mirzakhani E.	Food Sci Nutr	10.1002/fsn3.4298	2024
	In Vivo Functional Properties of Dairy Bacteria.	Aprea G, Del Matto I, Tucci P, Marino L, Scattolini S, Rossi F.	Microorganisms	10.3390/microorganisms11071787	2023
	Unveiling the Potential Ways to Apply Citrus Oil to Control Causative Agents of Pullorum Disease and Fowl Typhoid in Floor Materials.	Julianingsih D, Tung CW, Thapa K, Biswas D.	Animals (Basel)	10.3390/ani14010023	2023
	Changes in Cell Membrane Fatty Acid Composition of Streptococcus thermophilus in Response to Gradually Increasing Heat Temperature.	Min B, Kim K, Li V, Cho S, Kim H.	J Microbiol Biotechnol	10.4014/jmb.1912.12053	2020
Genetics	The genomic basis of the Streptococcus thermophilus health-promoting properties.	Roux E, Nicolas A, Valence F, Siekaniec G, Chuat V, Nicolas J, Le Loir Y, Guedon E.	BMC Genomics	10.1186/s12864-022-08459-y	2022
	Assessing probiotic viability in mixed species yogurt using a novel propidium monoazide (PMAxx)-quantitative PCR method.	Marole TA, Sibanda T, Buys EM.	Front Microbiol	10.3389/fmicb.2024.1325268	2024
	Enzyme-treated chicory for cosmetics: application assessment and techno-economic analysis.	Hakkinen ST, Cankar K, Nohynek L, Suomalainen M, van Arkel J, Siika-Aho M, Twarogowska A, Van Droogenbroeck B, Oksman-Caldentey KM.	AMB Express	10.1186/s13568-022-01494-8	2022
	Pneumatically Driven Microfluidic Platform and Fully Automated Particle Concentration System for the Capture and Enrichment of Pathogens.	Choi HJ, Ahn G, Yu US, Kim EJ, Ahn JY, Chan Jeong O.	ACS Omega	10.1021/acsomega.3c02264	2023
Pathogenicity	Probiotics Modulate Host Immune Response and Interact with the Gut Microbiota: Shaping Their Composition and Mediating Antibiotic Resistance.	Mousa WK, Mousa S, Ghemrawi R, Obaid D, Sarfraz M, Chehadeh F, Husband S.	Int J Mol Sci	10.3390/ijms241813783	2023
Pathogenicity	Characterization of the anti-Staphylococcus aureus fraction from Penthorum chinense Pursh stems.	Ding B, Ding Q, Zhang S, Jin Z, Wang Z, Li S, Dou X.	BMC Complement Altern Med	10.1186/s12906-019-2632-3	2019
	An efficient process for co-production of gamma-aminobutyric acid and probiotic Bacillus subtilis cells.	Wang H, Huang J, Sun L, Xu F, Zhang W, Zhan J.	Food Sci Biotechnol	10.1007/s10068-018-0461-7	2019
	Beneficial, safety, and antioxidant properties of lactic acid bacteria: A next step in their evaluation as potential probiotics.	Rwubuzizi R, Kim H, Holzapfel WH, Todorov SD.	Heliyon	10.1016/j.heliyon.2023.e15610	2023
	Streptococcus thermophiles DMST-H2 Promotes Recovery in Mice with Antibiotic-Associated Diarrhea.	Hu JS, Huang YY, Kuang JH, Yu JJ, Zhou QY, Liu DM.	Microorganisms	10.3390/microorganisms8111650	2020
	Structure similarity and molecular networking analysis for the discovery of polyphenol biotransformation products of gut microbes.	Xu R, Lee J, Zhang S, Chen L, Zhu J.	Anal Chim Acta	10.1016/j.aca.2022.340145	2022
Enzymology	Hydrolytic Enzymes Producing Bacterial Endophytes of Some Poaceae Plants.	Dogan G, Taskin B.	Pol J Microbiol	10.33073/pjm-2021-026	2021
Pathogenicity	Sulfites inhibit the growth of four species of beneficial gut bacteria at concentrations regarded as safe for food.	Irwin SV, Fisher P, Graham E, Malek A, Robidoux A.	PLoS One	10.1371/journal.pone.0186629	2017
Pathogenicity	Gut-joint axis: Oral Probiotic ameliorates Osteoarthritis.	Amin U, Jiang R, Raza SM, Fan M, Liang L, Feng N, Li X, Yang Y, Guo F.	J Tradit Complement Med	10.1016/j.jtcme.2023.06.002	2024
	Phenolic constituents of extract from mao luang seeds and skinâ??pulp residue and its antiradical and antimicrobial capacities	BUTKHUP L, SAMAPPITO S.	J Food Biochem	10.1111/j.1745-4514.2010.00491.x	2011
	Development of a Novel Chimeric Endolysin, Lys109 With Enhanced Lytic Activity Against Staphylococcus aureus.	Son B, Kong M, Lee Y, Ryu S.	Front Microbiol	10.3389/fmicb.2020.615887	2020
	Identification and characterization of lactic acid bacteria isolated from traditional cone yoghurt.	Bostan K, Unver Alcay A, Yalcin S, Eren Vapur U, Nizamlioglu M.	Food Sci Biotechnol	10.1007/s10068-017-0222-z	2017
Metabolism	Enhancing the Sweetness of Yoghurt through Metabolic Remodeling of Carbohydrate Metabolism in Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus.	Sorensen KI, Curic-Bawden M, Junge MP, Janzen T, Johansen E.	Appl Environ Microbiol	10.1128/aem.00462-16	2016
	Engineered phage with antibacterial CRISPR-Cas selectively reduce E. coli burden in mice.	Gencay YE, Jasinskyte D, Robert C, Semsey S, Martinez V, Petersen AO, Brunner K, de Santiago Torio A, Salazar A, Turcu IC, Eriksen MK, Koval L, Takos A, Pascal R, Schou TS, Bayer L, Bryde T, Johansen KC, Bak EG, Smrekar F, Doyle TB, Satlin MJ, Gram A, Carvalho J, Jessen L, Hallstrom B, Hink J, Damholt B, Troy A, Grove M, Clube J, Grondahl C, Haaber JK, van der Helm E, Zdravkovic M, Sommer MOA.	Nat Biotechnol	10.1038/s41587-023-01759-y	2024
	Enhancement of yogurt functionality by adding Mentha piprita phenolic extract and evaluation of its quality during cold storage.	Guemidi C, Ait Saada D, Ait Chabane O, Elmastas M, Erenler R, Yilmaz MA, Tarhan A, Akkal S, Khelifi H.	Food Sci Nutr	10.1002/fsn3.3981	2024
Genetics	Information Theoretic Metagenome Assembly Allows the Discovery of Disease Biomarkers in Human Microbiome.	Nalbantoglu OU.	Entropy (Basel)	10.3390/e23020187	2021
Metabolism	Crystal Structure of LysB4, an Endolysin from Bacillus cereus-Targeting Bacteriophage B4.	Hong S, Son B, Ryu S, Ha NC.	Mol Cells	10.14348/molcells.2018.0379	2019
	Lysyl-Phosphatidylglycerol: A Lipid Involved in the Resistance of Staphylococcus aureus to Antimicrobial Peptide Activity.	Vasquez A, Leidy C, Manrique-Moreno M.	Antibiotics (Basel)	10.3390/antibiotics14040349	2025
Metabolism	Small noncoding RNA sRNA0426 is involved in regulating biofilm formation in Streptococcus mutans.	Yin L, Zhu W, Chen D, Zhou Y, Lin H.	Microbiologyopen	10.1002/mbo3.1096	2020
Metabolism	Milk Proteins-Their Biological Activities and Use in Cosmetics and Dermatology.	Kazimierska K, Kalinowska-Lis U.	Molecules	10.3390/molecules26113253	2021
Metabolism	Enhanced Heavy Metal Tolerance and Accumulation by Transgenic Sugar Beets Expressing Streptococcus thermophilus StGCS-GS in the Presence of Cd, Zn and Cu Alone or in Combination.	Liu D, An Z, Mao Z, Ma L, Lu Z.	PLoS One	10.1371/journal.pone.0128824	2015
Enzymology	ThyA as a selection marker in construction of food-grade host-vector and integration systems for Streptococcus thermophilus.	Sasaki Y, Ito Y, Sasaki T.	Appl Environ Microbiol	10.1128/aem.70.3.1858-1864.2004	2004
	Characterization of a minimal pKW2124 replicon from Weissella cibaria KLC140 and its application for the construction of the Weissella expression vector pKUCm1.	Ku HJ, Park MS, Lee JH.	Front Microbiol	10.3389/fmicb.2015.00035	2015
	Distribution of two-component signal transduction systems BlpRH and ComDE across streptococcal species.	Dhaked HPS, Biswas I.	Front Microbiol	10.3389/fmicb.2022.960994	2022
Biotechnology	Salmonella enterica and Escherichia coli in Wheat Flour: Detection and Serotyping by a Quasimetagenomic Approach Assisted by Magnetic Capture, Multiple-Displacement Amplification, and Real-Time Sequencing.	Forghani F, Li S, Zhang S, Mann DA, Deng X, den Bakker HC, Diez-Gonzalez F.	Appl Environ Microbiol	10.1128/aem.00097-20	2020
Metabolism	Characterization of LysB4, an endolysin from the Bacillus cereus-infecting bacteriophage B4.	Son B, Yun J, Lim JA, Shin H, Heu S, Ryu S.	BMC Microbiol	10.1186/1471-2180-12-33	2012
Enzymology	Genetic and biochemical characterization of the phosphoenolpyruvate:glucose/mannose phosphotransferase system of Streptococcus thermophilus.	Cochu A, Vadeboncoeur C, Moineau S, Frenette M.	Appl Environ Microbiol	10.1128/aem.69.9.5423-5432.2003	2003
	Characterization of the cro-ori region of the Streptococcus thermophilus virulent bacteriophage DT1.	Lamothe G, Levesque C, Bissonnette F, Cochu A, Vadeboncoeur C, Frenette M, Duplessis M, Tremblay D, Moineau S.	Appl Environ Microbiol	10.1128/aem.71.3.1237-1246.2005	2005
Metabolism	Probiotics-host communication: Modulation of signaling pathways in the intestine.	Thomas CM, Versalovic J.	Gut Microbes	10.4161/gmic.1.3.11712	2010
Enzymology	Purification, Characterization, Identification, and Anticancer Activity of a Circular Bacteriocin From Enterococcus thailandicus.	Al-Madboly LA, El-Deeb NM, Kabbash A, Nael MA, Kenawy AM, Ragab AE.	Front Bioeng Biotechnol	10.3389/fbioe.2020.00450	2020
	Effect of water activity aw of milk on acid production by Streptococcus thermophilus and Lactobacillus bulgaricus	Larsen RF, Anon MC.	J Food Sci	10.1111/j.1365-2621.1989.tb07912.x	1989
	Interaction of antibiotics and water activity on Streptococcus thermophilus and Lactobacillus bulgaricus	Larson RF, Anon MC.	J Food Sci	10.1111/j.1365-2621.1989.tb07913.x	1989
	Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies.	Hudson LE, Anderson SE, Corbett AH, Lamb TJ.	Clin Microbiol Rev	10.1128/cmr.00049-16	2017
Metabolism	Resistance phenotypes mediated by aminoacyl-phosphatidylglycerol synthases.	Arendt W, Hebecker S, Jager S, Nimtz M, Moser J.	J Bacteriol	10.1128/jb.06576-11	2012
Metabolism	Dietary supplementation with probiotics during late pregnancy: outcome on vaginal microbiota and cytokine secretion.	Vitali B, Cruciani F, Baldassarre ME, Capursi T, Spisni E, Valerii MC, Candela M, Turroni S, Brigidi P.	BMC Microbiol	10.1186/1471-2180-12-236	2012
	Anaerobic fermentation of Lactobacillus bulgaricus and streptococcus thermophilus on 3% nonfat dry milk with pure and mixed culture.	Oner MD, Erickson LE.	Biotechnol Bioeng	10.1002/bit.260280616	1986
Proteome	Proteome analysis of Streptococcus thermophilus grown in milk reveals pyruvate formate-lyase as the major upregulated protein.	Derzelle S, Bolotin A, Mistou MY, Rul F.	Appl Environ Microbiol	10.1128/aem.71.12.8597-8605.2005	2005
	Analysis of exponential growth data for yoghurt cultures.	Oner MD, Erickson LE, Yang SS.	Biotechnol Bioeng	10.1002/bit.260280617	1986
Phylogeny	Bifidobacterium lactis DSM 10140: identification of the atp (atpBEFHAGDC) operon and analysis of its genetic structure, characteristics, and phylogeny.	Ventura M, Canchaya C, van Sinderen D, Fitzgerald GF, Zink R.	Appl Environ Microbiol	10.1128/aem.70.5.3110-3121.2004	2004
Enzymology	pH gradient and distribution of streptococci, lactobacilli, prevotellae, and fusobacteria in carious dentine.	Kianoush N, Nguyen KA, Browne GV, Simonian M, Hunter N.	Clin Oral Investig	10.1007/s00784-013-1009-0	2014
	An effective strategy, applicable to Streptococcus salivarius and related bacteria, to enhance or confer electroporation competence.	Buckley ND, Vadeboncoeur C, LeBlanc DJ, Lee LN, Frenette M.	Appl Environ Microbiol	10.1128/aem.65.9.3800-3804.1999	1999
Metabolism	A novel probiotic, Lactobacillus johnsonii 456, resists acid and can persist in the human gut beyond the initial ingestion period.	Davoren MJ, Liu J, Castellanos J, Rodriguez-Malave NI, Schiestl RH.	Gut Microbes	10.1080/19490976.2018.1547612	2019
	Hydrophobic and electrostatic cell surface properties of thermophilic dairy streptococci.	van der Mei HC, de Vries J, Busscher HJ.	Appl Environ Microbiol	10.1128/aem.59.12.4305-4312.1993	1993
	Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine.	Bruni N, Capucchio MT, Biasibetti E, Pessione E, Cirrincione S, Giraudo L, Corona A, Dosio F.	Molecules	10.3390/molecules21060752	2016
Pathogenicity	Growth of some lactic acid bacteria in milk containing sulfadiazine.	Soback S.	Acta Vet Scand	10.1186/bf03548674	1981
	Protective effect of adonitol on lactic acid bacteria subjected to freeze-drying.	de Valdez GF, de Giori GS, de Ruiz Holgado AA, Oliver G.	Appl Environ Microbiol	10.1128/aem.45.1.302-304.1983	1983
	Effect of the rehydration medium on the recovery of freeze-dried lactic acid bacteria.	de Valdez GF, de Giori GS, de Ruiz Holgado AP, Oliver G.	Appl Environ Microbiol	10.1128/aem.50.5.1339-1341.1985	1985
Enzymology	Distribution of proteins similar to IIIManH and IIIManL of the Streptococcus salivarius phosphoenolpyruvate:mannose-glucose phosphotransferase system among oral and nonoral bacteria.	Pelletier M, Frenette M, Vadeboncoeur C.	J Bacteriol	10.1128/jb.177.9.2270-2275.1995	1995
	Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes.	Newton GL, Arnold K, Price MS, Sherrill C, Delcardayre SB, Aharonowitz Y, Cohen G, Davies J, Fahey RC, Davis C.	J Bacteriol	10.1128/jb.178.7.1990-1995.1996	1996
Phylogeny	Performances of VITEK 2 colorimetric cards for identification of gram-positive and gram-negative bacteria.	Wallet F, Loiez C, Renaux E, Lemaitre N, Courcol RJ.	J Clin Microbiol	10.1128/jcm.43.9.4402-4406.2005	2005
Metabolism	Current status and emerging role of glutathione in food grade lactic acid bacteria.	Pophaly SD, Singh R, Pophaly SD, Kaushik JK, Tomar SK.	Microb Cell Fact	10.1186/1475-2859-11-114	2012
	Transcriptional enhancement of the Listeria monocytogenes PCR and simple immunoenzymatic assay of the product using anti-RNA:DNA antibodies.	Blais BW.	Appl Environ Microbiol	10.1128/aem.60.1.348-352.1994	1994
	Effect of drying medium on residual moisture content and viability of freeze-dried lactic Acid bacteria.	de Valdez GF, de Giori GS, de Ruiz Holgado AP, Oliver G.	Appl Environ Microbiol	10.1128/aem.49.2.413-415.1985	1985
	The genus Weissella: taxonomy, ecology and biotechnological potential.	Fusco V, Quero GM, Cho GS, Kabisch J, Meske D, Neve H, Bockelmann W, Franz CM.	Front Microbiol	10.3389/fmicb.2015.00155	2015
Enzymology	Cloning of the Lactococcus lactis adhE gene, encoding a multifunctional alcohol dehydrogenase, by complementation of a fermentative mutant of Escherichia coli.	Arnau J, Jorgensen F, Madsen SM, Vrang A, Israelsen H.	J Bacteriol	10.1128/jb.180.12.3049-3055.1998	1998
	Conjugative mobilization as an alternative vector delivery system for lactic streptococci.	Romero DA, Slos P, Robert C, Castellino I, Mercenier A.	Appl Environ Microbiol	10.1128/aem.53.10.2405-2413.1987	1987
	PCR amplification of the fimA gene sequence of Salmonella typhimurium, a specific method for detection of Salmonella spp.	Cohen HJ, Mechanda SM, Lin W.	Appl Environ Microbiol	10.1128/aem.62.12.4303-4308.1996	1996
	Your Regulatory T Cells Are What You Eat: How Diet and Gut Microbiota Affect Regulatory T Cell Development.	Tan J, Taitz J, Sun SM, Langford L, Ni D, Macia L.	Front Nutr	10.3389/fnut.2022.878382	2022
Biotechnology	Soleris®Enterobacteriaceae for the Detection of Enterobacteriaceae in Select Foods: AOAC Performance Tested MethodSM 121901.	Alles S, Roman B, Betts G, Jordan S, Everis L, Montei C, Biswas P, Mozola M, Donofrio R.	J AOAC Int	10.1093/jaoacint/qsaa001	2020
	Fermented Colostrum Whey Upregulates Aquaporin-3 Expression in, and Proliferation of, Keratinocytes via p38/c-Jun N-Terminal Kinase Activation.	Seo SA, Park HJ, Han MG, Lee R, Kim JS, Park JH, Lee WY, Song H.	Food Sci Anim Resour	10.5851/kosfa.2021.e33	2021
Pathogenicity	Antimicrobial and Antibiofilm Activities of Sulfated Polysaccharides from Marine Algae against Dental Plaque Bacteria.	Jun JY, Jung MJ, Jeong IH, Yamazaki K, Kawai Y, Kim BM.	Mar Drugs	10.3390/md16090301	2018
Metabolism	Antimicrobials from Seaweeds for Food Applications.	Cabral EM, Oliveira M, Mondala JRM, Curtin J, Tiwari BK, Garcia-Vaquero M.	Mar Drugs	10.3390/md19040211	2021
Metabolism	Characterization of leucocin B-KM432Bz from Leuconostoc pseudomesenteroides isolated from boza, and comparison of its efficiency to pediocin PA-1.	Makhloufi KM, Carre-Mlouka A, Peduzzi J, Lombard C, van Reenen CA, Dicks LM, Rebuffat S.	PLoS One	10.1371/journal.pone.0070484	2013
	Nutritional and Phytochemical Composition and Associated Health Benefits of Oat (Avena sativa) Grains and Oat-Based Fermented Food Products.	Alemayehu GF, Forsido SF, Tola YB, Amare E.	ScientificWorldJournal	10.1155/2023/2730175	2023
	Oat Yogurts Enriched with Synbiotic Microcapsules: Physicochemical, Microbiological, Textural and Rheological Properties during Storage.	Luca L, Oroian M.	Foods	10.3390/foods11070940	2022
	Plant-Based Alternatives to Yogurt: State-of-the-Art and Perspectives of New Biotechnological Challenges.	Montemurro M, Pontonio E, Coda R, Rizzello CG.	Foods	10.3390/foods10020316	2021
	Evaluation of instrumental and sensory measurements using multivariate analysis in probiotic yogurt enriched with almond milk.	Yilmaz-Ersan L, Topcuoglu E.	J Food Sci Technol	10.1007/s13197-021-04994-w	2022
	Coconut milk beverage fermented by Lactobacillus reuteri: optimization process and stability during refrigerated storage.	Mauro CSI, Garcia S.	J Food Sci Technol	10.1007/s13197-018-3545-8	2019
Cultivation	A new selective medium for Bifidobacterium spp.	Nebra Y, Blanch AR.	Appl Environ Microbiol	10.1128/aem.65.11.5173-5176.1999	1999
Pathogenicity	Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms.	Xiao Y, Feng Y, Zhao J, Chen W, Lu W.	J Adv Res	10.1016/j.jare.2024.03.005	2025
	Molecular Identification and Selection of Probiotic Strains Able to Reduce the Serum TMAO Level in Mice Challenged with Choline.	Ramireddy L, Tsen HY, Chiang YC, Hung CY, Wu SR, Young SL, Lin JS, Huang CH, Chiu SH, Chen CC, Chen CC.	Foods	10.3390/foods10122931	2021
	A Review of the Impact of Maternal Prenatal Stress on Offspring Microbiota and Metabolites.	Yeramilli V, Cheddadi R, Shah J, Brawner K, Martin C.	Metabolites	10.3390/metabo13040535	2023
	Interplay of Good Bacteria and Central Nervous System: Cognitive Aspects and Mechanistic Considerations.	Salami M.	Front Neurosci	10.3389/fnins.2021.613120	2021
	Lactobacillus plantarum TWK10 Attenuates Aging-Associated Muscle Weakness, Bone Loss, and Cognitive Impairment by Modulating the Gut Microbiome in Mice.	Lee CC, Liao YC, Lee MC, Lin KJ, Hsu HY, Chiou SY, Young SL, Lin JS, Huang CC, Watanabe K.	Front Nutr	10.3389/fnut.2021.708096	2021
	Development of culture methods capable of culturing a wide range of predominant species of intestinal bacteria.	Hirano R, Nishita I, Nakai R, Bito A, Sasabe R, Kurihara S.	Front Cell Infect Microbiol	10.3389/fcimb.2023.1056866	2023
Genetics	Genomic and transcriptomic analysis of genes involved in exopolysaccharide biosynthesis by Streptococcus thermophilus IMAU20561 grown on different sources of nitrogen.	Wang Y, Peng Q, Liu Y, Wu N, He Y, Cui X, Dan T.	Front Microbiol	10.3389/fmicb.2023.1328824	2023
Metabolism	Genomic and Metabolic Features of an Unexpectedly Predominant, Thermophilic, Assistant Starter Microorganism, Thermus thermophilus, in Chinese Inner Mongolian Cheese.	Zhu L, Hou Z, Hu X, Liu X, Dai T, Wang X, Zeng C, Wang Y, Wang C, Yang S, Cui H, Wei W.	Foods	10.3390/foods10122962	2021
Genetics	Bacteriocin Producing Streptococcus agalactiae Strains Isolated from Bovine Mastitis in Brazil.	Vidal Amaral JR, Juca Ramos RT, Almeida Araujo F, Bentes Kato R, Figueira Aburjaile F, de Castro Soares S, Goes-Neto A, Matiuzzi da Costa M, Azevedo V, Brenig B, Soares de Oliveira S, Soares Rosado A.	Microorganisms	10.3390/microorganisms10030588	2022
	In vitro and in vivo production and split-intein mediated ligation (SIML) of circular bacteriocins.	Pena N, Bland MJ, Sevillano E, Munoz-Atienza E, Lafuente I, Bakkoury ME, Cintas LM, Hernandez PE, Gabant P, Borrero J.	Front Microbiol	10.3389/fmicb.2022.1052686	2022
Phylogeny	Bioinformatic prospecting and phylogenetic analysis reveals 94 undescribed circular bacteriocins and key motifs.	Vezina B, Rehm BHA, Smith AT.	BMC Microbiol	10.1186/s12866-020-01772-0	2020
Metabolism	Microbial exopolysaccharide production of Streptococcus thermophilus and its antiquorum sensing activity.	Karadeniz DG, Kaskatepe B, Kiymaci ME, Tok KC, Gumustas M, Karaaslan C	Arch Microbiol	10.1007/s00203-021-02313-7	2021
Metabolism	Evaluation of acrylamide-removing properties of bacterial consortia under simulated gastrointestinal conditions.	Torres-Gregorio M, Santiago-Lopez L, Vallejo-Cordoba B, Gonzalez-Cordova AF, Garcia HS, Hernandez-Mendoza A	J Sci Food Agric	10.1002/jsfa.11149	2021
	Probiotic Potential and Technological Properties of Bacteriocinogenic Lactococcus lactis Subsp. Lactis UTNGt28 from a Native Amazonian Fruit as a Yogurt Starter Culture.	Tenea GN, Suarez J	Microorganisms	10.3390/microorganisms8050733	2020
Metabolism	Lactobacillus gasseri SBT2055 suppresses fatty acid release through enlargement of fat emulsion size in vitro and promotes fecal fat excretion in healthy Japanese subjects.	Ogawa A, Kobayashi T, Sakai F, Kadooka Y, Kawasaki Y	Lipids Health Dis	10.1186/s12944-015-0019-0	2015
Metabolism	Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes.	Yu ZT, Chen C, Newburg DS	Glycobiology	10.1093/glycob/cwt065	2013
Biotechnology	Characterization of urease genes cluster of Streptococcus thermophilus.	Mora D, Maguin E, Masiero M, Parini C, Ricci G, Manachini PL, Daffonchio D	J Appl Microbiol	10.1046/j.1365-2672.2003.02148.x	2004
Metabolism	Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC).	Resta-Lenert S, Barrett KE	Gut	10.1136/gut.52.7.988	2003
Enzymology	Hydrolysis of sequenced beta-casein peptides provides new insight into peptidase activity from thermophilic lactic acid bacteria and highlights intrinsic resistance of phosphopeptides.	Deutsch SM, Molle D, Gagnaire V, Piot M, Atlan D, Lortal S	Appl Environ Microbiol	10.1128/AEM.66.12.5360-5367.2000	2000
	Application of the extracellular alpha-amylase gene from Streptococcus bovis 148 to construction of a secretion vector for yogurt starter strains.	Satoh E, Ito Y, Sasaki Y, Sasaki T	Appl Environ Microbiol	10.1128/aem.63.11.4593-4596.1997	1997
Enzymology	Aminopeptidase N from Streptococcus salivarius subsp. thermophilus NCDO 573: purification and properties.	Midwinter RG, Pritchard GG	J Appl Bacteriol	10.1111/j.1365-2672.1994.tb03076.x	1994
Enzymology	Analysis of the lacZ sequences from two Streptococcus thermophilus strains: comparison with the Escherichia coli and Lactobacillus bulgaricus beta-galactosidase sequences.	Schroeder CJ, Robert C, Lenzen G, McKay LL, Mercenier A	J Gen Microbiol	10.1099/00221287-137-2-369	1991
Genetics	Genome analysis of Streptococcus salivarius subsp. thermophilus type strain ATCC 19258 and its comparison to equivalent strain NCTC 12958.	Cho H, Park KE, Kim KS	Arch Microbiol	10.1007/s00203-020-02156-8	2021
	Role of Temperate Bacteriophage varphi20617 on Streptococcus thermophilus DSM 20617(T) Autolysis and Biology.	Arioli S, Eraclio G, Della Scala G, Neri E, Colombo S, Scaloni A, Fortina MG, Mora D	Front Microbiol	10.3389/fmicb.2018.02719	2018
Metabolism	Characterization of tetA-like gene encoding for a major facilitator superfamily efflux pump in Streptococcus thermophilus.	Arioli S, Guglielmetti S, Amalfitano S, Viti C, Marchi E, Decorosi F, Giovannetti L, Mora D	FEMS Microbiol Lett	10.1111/1574-6968.12449	2014
	Temperate Streptococcus thermophilus phages expressing superinfection exclusion proteins of the Ltp type.	Ali Y, Koberg S, Hessner S, Sun X, Rabe B, Back A, Neve H, Heller KJ	Front Microbiol	10.3389/fmicb.2014.00098	2014
Pathogenicity	Effect of D-alanine in teichoic acid from the Streptococcus thermophilus cell wall on the barrier-protection of intestinal epithelial cells.	Miyauchi E, Morita M, Rossi M, Morita H, Suzuki T, Tanabe S	Biosci Biotechnol Biochem	10.1271/bbb.110646	2012
Pathogenicity	Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells.	Ogita T, Nakashima M, Morita H, Saito Y, Suzuki T, Tanabe S	J Biomed Biotechnol	10.1155/2011/378417	2011
Metabolism	Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ.	Shimosato T, Tohno M, Sato T, Nishimura J, Kawai Y, Saito T, Kitazawa H	Anim Sci J	10.1111/j.1740-0929.2009.00680.x	2009
Metabolism	The relevance of carbon dioxide metabolism in Streptococcus thermophilus.	Arioli S, Roncada P, Salzano AM, Deriu F, Corona S, Guglielmetti S, Bonizzi L, Scaloni A, Mora D	Microbiology (Reading)	10.1099/mic.0.024737-0	2009
Metabolism	Carbamoylphosphate synthetase activity is essential for the optimal growth of Streptococcus thermophilus in milk.	Arioli S, Monnet C, Guglielmetti S, Mora D	J Appl Microbiol	10.1111/j.1365-2672.2009.04213.x	2009
Metabolism	[Comparison of genotypic and biochemical characteristics of Streptococcus thermophilus strains isolated from sour milk products].	Botina SG, Trenina MA, Tsygankov IuD, Sukhodolets VV	Prikl Biokhim Mikrobiol		2007
Metabolism	Urease biogenesis in Streptococcus thermophilus.	Mora D, Monnet C, Parini C, Guglielmetti S, Mariani A, Pintus P, Molinari F, Daffonchio D, Manachini PL	Res Microbiol	10.1016/j.resmic.2005.04.005	2005
Metabolism	The doubly phosphorylated form of HPr, HPr(Ser~P)(His-P), is abundant in exponentially growing cells of Streptococcus thermophilus and phosphorylates the lactose transporter LacS as efficiently as HPr(His~P).	Cochu A, Roy D, Vaillancourt K, Lemay JD, Casabon I, Frenette M, Moineau S, Vadeboncoeur C	Appl Environ Microbiol	10.1128/AEM.71.3.1364-1372.2005	2005
Phylogeny	[Divergence in the level of DNA hybridization and formation of sibling species in the lactic acid bacteria Streptococcus thermophilus].	Lysenko AM, Botina SG, Ganina VI, Sukhodolets VV	Mikrobiologiia		2001
	Effect of Carbohydrate on the Viability of Streptococcus thermophilus.	Sinha RP	J Food Prot	10.4315/0362-028X-54.7.537	1991
Metabolism	Oxygen uptake activity and aerobic metabolism of Streptococcus thermophilus STH450.	Teraguchi S, Ono J, Kiyosawa I, Okonogi S	J Dairy Sci	10.3168/jds.S0022-0302(87)80036-X	1987
Phylogeny	Aspromonas composti gen. nov., sp. nov., a novel member of the family Xanthomonadaceae.	Jin L, Kim KK, Im WT, Yang HC, Lee ST.	Int J Syst Evol Microbiol	10.1099/ijs.0.64472-0	2007
Phylogeny	Streptococcus raffinosi sp. nov., isolated from human breast milk samples.	Nguyen HV, Trinh ATV, Bui LNH, Hoang ATL, Tran QTL, Trinh TT.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006442	2024

References

#8965	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20617
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#41772	; Curators of the CIP;
#47525	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 21957
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68370	Automatically annotated from API 20STR .
#68371	Automatically annotated from API 50CH acid .
#68381	Automatically annotated from API rID32STR .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#123510	Collection of Institut Pasteur ; Curators of the CIP; CIP 102303
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptococcus thermophilus (CCUG 21957, LMG 6896, CCTM 3104)

Name and taxonomic classification

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