Streptococcus oralis subsp. oralis (DSM 20627, ATCC 35037, KCTC 13048)

Name: Streptococcus oralis subsp. oralis (DSM 20627, ATCC 35037, KCTC 13048)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 14740

Type strain

Strain Designation LVG/l, PB182, PB 182

Culture col. no. DSM 20627 ATCC 35037 KCTC 13048 NCTC 11427 NBRC 113011 12 more

NCBI tax ID(s) 1303 1891914

Special Collections DSMZ CCUG JCM KCTC CIP

History DSMZ <- NCTC; NCTC 11427 <- P. H. A. Sneath; PB182 <- J. Carlson; LVG/l JCM <-- CCUG 13229 <-- NCTC 11427 <-- P. H. A. Sneath PB182 <-- J. Carlsson LVG/1. KCTC <- DSM <- NCTC <- PHA Sneath, PB182 <- J Carlsson, LVG/1(GroupIA) CIP <- 1987, NCTC <- P.H.A. Sneath: strain PB 182 <- J. Carlsson: strain LVG/1, Group IA

Links

Streptococcus oralis subsp. oralis LVG/l is a microaerophile, coccus-shaped bacterium that was isolated from human mouth.

coccus-shaped microaerophile genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 8045

LMG 14532,ATCC 35037,CCRC 14749,CCUG 13229,CCUG 24689,CCUG 24891,CIP 102922,DSM 20627,NCFB 2680,NCTC 11427,NBRC 113011,CCUG 25610,NCDO 2680,NCIMB 702680,CECT 907,KCTC 3285,BCRC 14749,JCM 12997,KCTC 13048

@ref 20215

Last LPSN update 2026-05-29 08:28:21

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Streptococcaceae

Genus Streptococcus

Species Streptococcus oralis subsp. oralis

Full scientific name Streptococcus oralis subsp. oralis (Bridge and Sneath 1982) Jensen et al. 2016

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
67771		coccus-shaped
67771	positive
125439			91.164
125438			90.5
125438	positive		90.102
121429	positive	coccus-shaped

Colony morphology

@ref	Type of hemolysis	Hemolysis ability	Incubation period
8975	alpha	1	1-2 days
121429		0

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
8975	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
8975	TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)	Medium recipe at MediaDive	Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water
42198	MEDIUM 72- for trypto casein soja agar		Distilled water make up to (1000.000 ml);Trypto casein soy agar (40.000 g)
121429	CIP Medium 72	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
8975	positive	growth	37
42198	positive	growth	37
67770	positive	growth	37
67771	positive	growth	37
121429	positive	growth	30
121429	negative	growth	10
121429	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
8975	microaerophile
67771	microaerophile
121429	facultative anaerobe
125439	facultative anaerobe	93.261

Spore formation

@ref	Spore formation	Confidence
67771
125439		97.055

Halophily

@ref	Salt	Growth	Tested relation	Concentration
121429	NaCl		growth	6.5 %

Murein

@ref	Murein short key	Type
8975	A11	A1alpha L-Lys-direct

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68381	40585 ChEBI	alpha-cyclodextrin	-	builds acid from	from API rID32STR
68381	29016 ChEBI	arginine	-	hydrolysis	from API rID32STR
68381	18333 ChEBI	D-arabitol	-	builds acid from	from API rID32STR
68381	16899 ChEBI	D-mannitol	-	builds acid from	from API rID32STR
68381	16988 ChEBI	D-ribose	-	builds acid from	from API rID32STR
68381	28087 ChEBI	glycogen	-	builds acid from	from API rID32STR
68381	606565 ChEBI	hippurate	-	hydrolysis	from API rID32STR
68381	30849 ChEBI	L-arabinose	-	builds acid from	from API rID32STR
68381	6731 ChEBI	melezitose	-	builds acid from	from API rID32STR
68381	28053 ChEBI	melibiose	-	builds acid from	from API rID32STR
68381	320055 ChEBI	methyl beta-D-glucopyranoside	-	builds acid from	from API rID32STR
121429	17632 ChEBI	nitrate	-	reduction
121429	16301 ChEBI	nitrite	-	reduction
68381	16634 ChEBI	raffinose	-	builds acid from	from API rID32STR
68381	30911 ChEBI	sorbitol	-	builds acid from	from API rID32STR
68381	27082 ChEBI	trehalose	+	builds acid from	from API rID32STR
68381	16199 ChEBI	urea	-	hydrolysis	from API rID32STR

Antibiotic resistance

@ref	Metabolite	Is sensitive	Is resistant
121429	0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68381	15688 ChEBI	acetoin		from API rID32STR

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test
68381	15688 ChEBI	acetoin	-	from API rID32STR

Enzymes

@ref	Value	Activity	Ec
68381	Alanyl-Phenylalanyl-Proline arylamidase	+		from API rID32STR
121429	alcohol dehydrogenase	-	1.1.1.1
68381	alkaline phosphatase	+	3.1.3.1	from API rID32STR
68381	alpha-galactosidase	-	3.2.1.22	from API rID32STR
68381	arginine dihydrolase	-	3.5.3.6	from API rID32STR
68381	beta-galactosidase	-	3.2.1.23	from API rID32STR
68381	beta-glucosidase	-	3.2.1.21	from API rID32STR
68381	beta-glucuronidase	-	3.2.1.31	from API rID32STR
68381	beta-mannosidase	-	3.2.1.25	from API rID32STR
8975	catalase	-	1.11.1.6
121429	catalase	-	1.11.1.6
8975	cytochrome-c oxidase	-	1.9.3.1
68381	glycyl tryptophan arylamidase	+		from API rID32STR
121429	lysine decarboxylase	-	4.1.1.18
121429	ornithine decarboxylase	-	4.1.1.17
121429	oxidase	-
68381	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32STR
68381	urease	-	3.5.1.5	from API rID32STR

API rID32STR

@ref	ADH (Arg)	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	TAG	beta MAN	URE
8975	-	-	+	-	-	+	-	-	-	+	+	-	+	-	-	-	-	+	-	-	-	+	-	-	+	+	-	-	-	+/-	-	-
8975	-	-	+	-	-	+	-	-	-	-	+	-	+/-	-	-	-	-	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-
8975	-	-	+	-	-	+	-	-	-	+	+	-	+	-	-	-	-	+	-	-	+/-	+	-	-	+	+	-	-	-	-	-	-
8975	-	-	+	-	-	+	-	-	-	+	+	-	+	-	-	-	-	+	-	-	-	+	-	-	+	+	-	-	-	-	-	-
8975	-	-	+	-	-	+	-	-	-	+	+	-	+	-	-	-	-	+	-	-	-	+	-	-	+	+/-	-	-	-	+/-	-	-
8975	-	-	+	-	-	+	-	-	-	+	+	-	+	-	-	-	-	+	-	-	-	+	-	-	+	+	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body-Site	#Oral cavity and airways	#Mouth

Isolation

@ref	Sample type	Host species
8975	human mouth	Homo sapiens
67770	Human mouth	Homo sapiens
67771	From Human mouth	Homo sapiens
121429	Human, Mouth	Homo sapiens

Taxonmaps

69479

Global distribution of 16S sequence LC383838 (>99% sequence identity) for Streptococcus from Microbeatlas

Aquatic Samples	1515
Soil Samples	819
Animal Samples	56551
Plant Samples	407
Total Samples	59292

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
8975	2	Risk group (German classification) According to TRBA 466
121429	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	46338_H01 assembly for Streptococcus oralis ATCC 35037 NCTC11427	complete	GCA_900637025	655813.19	2872627392	655813	99.36
124043	ASM1612755v1 assembly for Streptococcus oralis FDAARGOS_1020	complete	GCA_016127555	1303.920		1303	99.28
66792	ASM201488v1 assembly for Streptococcus oralis CCUG 13229	scaffold	GCA_002014885	1303.137	8043534465	1303	76.5
67771	ASM16409v1 assembly for Streptococcus oralis ATCC 35037	scaffold	GCA_000164095	655813.3	647000325	655813	74.75
66792	ASM14856v1 assembly for Streptococcus oralis ATCC 35037	contig	GCA_000148565	655813.4	648276739	655813	71.88
66792	ASM163937v1 assembly for Streptococcus oralis CCUG 24891	scaffold	GCA_001639375	1303.89	2744054846	1303	70.9

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptococcus oralis 16S ribosomal RNA gene, complete sequence	AF003932	1460	655813
20218	Streptococcus oralis strain ATCC 35037 16S-23S ribosomal RNA intergenic spacer, complete sequence	AY347551	246	655813
20218	Streptococcus oralis strain ATCC 35037 16S ribosomal RNA gene, partial sequence	EU156768	1269	655813
20218	Streptococcus oralis strain KCTC 13048 16S ribosomal RNA gene, partial sequence	GU045377	1421	1303
20218	Streptococcus oralis strain KCTC 13048 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence	HM241936	458	1303
20218	Streptococcus oralis ATCC 35037 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA internal transcribed spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence	JN181389	460	655813
20218	S.oralis 16S rRNA	X58308	1333	655813
8975	Streptococcus oralis strain ATCC 35037 16S small subunit ribosomal RNA gene, partial sequence	AY485602	1471	655813
67770	Streptococcus oralis subsp. oralis JCM 12997 gene for 16S ribosomal RNA, partial sequence	LC383838	1487	1891914
67771	Streptococcus oralis strain CCUG 24891 16S ribosomal RNA gene, partial sequence	DQ303190	1472	1303
124043	Streptococcus oralis ATCC 35037 gene for 16S rRNA, partial sequence.	LC752403	589	655813
124043	Streptococcus oralis ATCC 35037 16S ribosomal RNA gene, partial sequence.	OR501326	1430	655813

GC content

@ref	GC-content (mol%)
8975	39.9
67770	41

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: 46338_H01 assembly for Streptococcus oralis ATCC 35037 NCTC11427
BV-BRC: 655813.19

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	93.26	no
125439	gram_stain	BacteriaNetⓘ	positive	79.90	no
125439	motility	BacteriaNetⓘ	no	91.16	no
125439	spore_formation	BacteriaNetⓘ	no	97.06	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptococcus oralis ATCC 35037 NCTC11427
NCBI: GCA_900637025.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	90.10	yes
125438	anaerobic	anaerobicⓘ	no	89.94	yes
125438	aerobic	aerobicⓘ	no	98.30	yes
125438	spore-forming	spore-formingⓘ	no	86.78	yes
125438	thermophilic	thermophileⓘ	no	96.50	yes
125438	flagellated	motile2+ⓘ	no	90.50	yes

Literature

Topic	Title	Authors	Journal	DOI	Year
	Assessment of the Effect on Periodontitis of Antibiotic Therapy and Bacterial Lysate Treatment.	Ancuta DL, Alexandru DM, Muselin F, Cristina RT, Coman C.	Int J Mol Sci	10.3390/ijms25105432	2024
Phylogeny	Full-length 16S rRNA gene sequencing by PacBio improves taxonomic resolution in human microbiome samples.	Buetas E, Jordan-Lopez M, Lopez-Roldan A, D'Auria G, Martinez-Priego L, De Marco G, Carda-Dieguez M, Mira A.	BMC Genomics	10.1186/s12864-024-10213-5	2024
	Fluorescence Spectroscopy Shows Porphyrins Produced by Cultured Oral Bacteria Differ Depending on Composition of Growth Media.	Lennon AM, Brune L, Techert S, Buchalla W.	Caries Res	10.1159/000528731	2023
	A Comparative Analysis of the Efficacy of Bacterial Lysate versus Antibiotic Therapy in the Treatment of Experimental Peri-Implantitis in Rats.	Ancuta DL, Alexandru DM, Tucureanu C, Coman C.	Microorganisms	10.3390/microorganisms12081537	2024
	Thermoplastic Zinc-Infused Polymer for Chairside Socket Seal Abutments Enhances Antimicrobial and Tissue-Integrative Properties.	Van Holm W, Vandamme K, Hadisurya J, Pamuk F, Zayed N, Aktan MK, Braem A, Temmerman A, Teughels W.	Antibiotics (Basel)	10.3390/antibiotics14050441	2025
	Induction of Experimental Peri-Implantitis with Strains Selected from the Human Oral Microbiome.	Ancuta DL, Alexandru DM, Crivineanu M, Coman C.	Biomedicines	10.3390/biomedicines12040715	2024
	Spatiotemporal monitoring of a periodontal multispecies biofilm model: demonstration of prebiotic treatment responses.	Ghesquiere J, Simoens K, Koos E, Boon N, Teughels W, Bernaerts K.	Appl Environ Microbiol	10.1128/aem.01081-23	2023
	Induction of Periodontitis Using Bacterial Strains Isolated from the Human Oral Microbiome in an Experimental Rat Model.	Ancuta DL, Alexandru DM, Crivineanu M, Coman C.	Biomedicines	10.3390/biomedicines11082098	2023
	Evaluation of the Performance Characteristics of a New POC Multiplex PCR Assay for the Diagnosis of Viral and Bacterial Neuromeningeal Infections.	Le Bars H, Madany N, Lamoureux C, Beauruelle C, Vallet S, Payan C, Pilorge L.	Diagnostics (Basel)	10.3390/diagnostics13061110	2023
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	Effect of Low-Level Laser Irradiation (810 nm) on the Proliferation and Differentiation of Osteoblast-Like Cells Cultured on SLA Titanium Discs Exposed to a Peri-implantitis Environment.	Zampa EP, Kyriakidou K, Papaparaskevas J, Pepelassi E, Karoussis IK.	J Lasers Med Sci	10.34172/jlms.2023.57	2023
	Inhibitory effect of natural flavone luteolin on Streptococcus mutans biofilm formation.	Rudin L, Roth N, Kneubuhler J, Dubey BN, Bornstein MM, Shyp V.	Microbiol Spectr	10.1128/spectrum.05223-22	2023
	Antibacterial Effect of Cupral^® on Oral Biofilms - An In-Vitro Study.	Von Maltzahn NF, Stumpp NS, Stiesch M.	Eur Endod J	10.14744/eej.2019.83997	2020
	Assessment of Disinfection Potential of Q-Switch Nd: YAG Laser on Contaminated Titanium Implant Surfaces.	Namour M, Mobadder ME, Mulongo B, Fagnart O, Harb A, Peremans A, Verspecht T, Teughels W, Nammour S, Rompen E.	Materials (Basel)	10.3390/ma14206078	2021
	In Vitro Effects of Streptococcus oralis Biofilm on Peri-Implant Soft Tissue Cells.	Ingendoh-Tsakmakidis A, Eberhard J, Falk CS, Stiesch M, Winkel A.	Cells	10.3390/cells9051226	2020
Pathogenicity	Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model.	Ingendoh-Tsakmakidis A, Mikolai C, Winkel A, Szafranski SP, Falk CS, Rossi A, Walles H, Stiesch M.	Cell Microbiol	10.1111/cmi.13078	2019
	Assessing Antimicrobial Efficacy on Plastics and Other Non-Porous Surfaces: A Closer Look at Studies Using the ISO 22196:2011 Standard.	Bento de Carvalho T, Barbosa JB, Teixeira P.	Biology (Basel)	10.3390/biology13010059	2024
	Surface properties and initial bacterial biofilm growth on 3D-printed oral appliances: a comparative in vitro study.	Wuersching SN, Westphal D, Stawarczyk B, Edelhoff D, Kollmuss M.	Clin Oral Investig	10.1007/s00784-022-04838-7	2023
	Antimicrobial Mechanisms of Leucocyte- and Platelet Rich Fibrin Exudate Against Planktonic Porphyromonas gingivalis and Within Multi-Species Biofilm: A Pilot Study.	Rodriguez Sanchez F, Verspecht T, Castro AB, Pauwels M, Andres CR, Quirynen M, Teughels W.	Front Cell Infect Microbiol	10.3389/fcimb.2021.722499	2021
Metabolism	Potential prebiotic substrates modulate composition, metabolism, virulence and inflammatory potential of an in vitro multi-species oral biofilm.	Verspecht T, Van Holm W, Boon N, Bernaerts K, Daep CA, Masters JG, Zayed N, Quirynen M, Teughels W.	J Oral Microbiol	10.1080/20002297.2021.1910462	2021
	Mode of killing determines the necrotrophic response of oral bacteria.	Zayed N, Figueiredo J, Van Holm W, Boon N, Bernaerts K, Teughels W.	J Oral Microbiol	10.1080/20002297.2023.2184930	2023
	Erythritol-enriched powder and oral biofilm regrowth on dental implants: an in vitro study.	Amate-Fernandez P, Figueiredo R, Blanc V, Alvarez G, Leon R, Valmaseda-Castellon E.	Med Oral Patol Oral Cir Bucal	10.4317/medoral.24622	2021
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	Q-Switch Nd:YAG Laser-Assisted Elimination of Multi-Species Biofilm on Titanium Surfaces.	Namour M, Namour M, Verspecht T, El Mobadder M, Teughels W, Peremans A, Nammour S, Rompen E.	Materials (Basel)	10.3390/ma13071573	2020
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Phylogeny	INC-Seq: accurate single molecule reads using nanopore sequencing.	Li C, Chng KR, Boey EJ, Ng AH, Wilm A, Nagarajan N.	Gigascience	10.1186/s13742-016-0140-7	2016
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	Comparison of the modulatory effects of three structurally similar potential prebiotic substrates on an in vitro multi-species oral biofilm.	Verspecht T, Van Holm W, Boon N, Bernaerts K, Daep CA, Zayed N, Quirynen M, Teughels W.	Sci Rep	10.1038/s41598-021-94510-z	2021
Metabolism	Dysbiosis by neutralizing commensal mediated inhibition of pathobionts.	Herrero ER, Slomka V, Boon N, Bernaerts K, Hernandez-Sanabria E, Quirynen M, Teughels W.	Sci Rep	10.1038/srep38179	2016
	Use of an oligonucleotide array for laboratory diagnosis of bacteria responsible for acute upper respiratory infections.	Roth SB, Jalava J, Ruuskanen O, Ruohola A, Nikkari S.	J Clin Microbiol	10.1128/jcm.42.9.4268-4274.2004	2004
	Protective mechanisms of respiratory tract Streptococci against Streptococcus pyogenes biofilm formation and epithelial cell infection.	Fiedler T, Riani C, Koczan D, Standar K, Kreikemeyer B, Podbielski A.	Appl Environ Microbiol	10.1128/aem.03350-12	2013
Metabolism	Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms.	Rodriguez Herrero E, Boon N, Pauwels M, Bernaerts K, Slomka V, Quirynen M, Teughels W.	Sci Rep	10.1038/s41598-017-01239-9	2017
Phylogeny	Duplex quantitative real-time PCR assay for the detection and discrimination of the eggs of Toxocara canis and Toxocara cati (Nematoda, Ascaridoidea) in soil and fecal samples.	Durant JF, Irenge LM, Fogt-Wyrwas R, Dumont C, Doucet JP, Mignon B, Losson B, Gala JL.	Parasit Vectors	10.1186/1756-3305-5-288	2012
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Enzymology	Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes.	Franks AH, Harmsen HJ, Raangs GC, Jansen GJ, Schut F, Welling GW.	Appl Environ Microbiol	10.1128/aem.64.9.3336-3345.1998	1998
	Complete genome sequence of Streptococcus oralis subsp. tigurinus J22, a model strain for antagonistic interaction against Streptococcus mutans.	Jung H-Y, Cai J-N, Kim D.	Microbiol Resour Announc	10.1128/mra.00677-25	2025
	Antibiofilm potential of plant extracts: inhibiting oral microorganisms and Streptococcus mutans.	Bartels N, Argyropoulou A, Al-Ahmad A, Hellwig E, Skaltsounis AL, Wittmer A, Vach K, Karygianni L.	Front Dent Med	10.3389/fdmed.2025.1535753	2025
	Unleashing nature's defense: potent antimicrobial power of plant extracts against oral pathogens and Streptococcus mutans biofilms.	Hickl J, Argyropoulou A, Al-Ahmad A, Hellwig E, Skaltsounis AL, Wittmer A, Vach K, Karygianni L.	Front Oral Health	10.3389/froh.2024.1469174	2024
Genetics	Whole-genome sequencing and analysis of a novel strain Streptococcus oralis CRC211 from colorectal tumor.	Shi Y, Liu L, Wu J, Gao M, Sheng K, Hou W, Li X, Wang H.	Microbiome Res Rep	10.20517/mrr.2025.41	2025
	Functional divergence of MdpS and MdpS2 reveals mucin-targeting strategies in Streptococcus oralis.	Leo F, Nilsson J, Arike L, Kumar S, Hilton E, Lood R, Thornton DJ, Duncan GA, Svensater G, Wickstrom C.	J Oral Microbiol	10.1080/20002297.2025.2571186	2025
	Caffeic acid phenethyl ester inhibits multispecies biofilm formation and cariogenicity.	Kokilakanit P, Dungkhuntod N, Serikul N, Koontongkaew S, Utispan K.	PeerJ	10.7717/peerj.18942	2025
	Effect of Surface Wettability and Energy on Bacterial Adhesion to Dental Aligners: A Comparative In Vitro Study.	Martinez Gil-Ortega A, Paz-Cortes MM, Vinas MJ, Cintora-Lopez P, Martin-Vacas A, Gil J, Aragoneses JM.	Bioengineering (Basel)	10.3390/bioengineering12090898	2025
	Unveiling the impact of allulose on oral microbiota and biofilm formation via a cariogenic potential assessment platform.	Han S, Rajitha K, Park S, Lim J, Jung HY, Kim J, Kim D.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1670139	2025
	Pathogenic effects of Streptococcus oralis intestinal colonization on bladder health in mice.	Nakamura N, Iioka K, Morisaki H, Okahashi N, Kurosawa M, Fukamachi H, Matsui S, Funatsu T, Kuwata H, Itsumi M.	Curr Res Microb Sci	10.1016/j.crmicr.2025.100375	2025
	Co-culture of Helicobacter pylori with oral microorganisms in human saliva.	Scholz KJ, Hohne A, Wittmer A, Hacker G, Hellwig E, Cieplik F, Waidner B, Al-Ahmad A.	Clin Oral Investig	10.1007/s00784-025-06160-4	2025
	3Y-TZP/Ta Biocermet as a Dental Material: An Analysis of the In Vitro Adherence of Streptococcus Oralis Biofilm and an In Vivo Pilot Study in Dogs.	Smirnov A, Yanushevich O, Krikheli N, Solis Pinargote NW, Peretyagin P, Grigoriev S, Alou L, Sevillano D, Lopez-Piriz R, Guitian F, Bartolome JF.	Antibiotics (Basel)	10.3390/antibiotics13020175	2024
	In Vitro Eradication of Planktonic, Saliva and Biofilm Bacteria Using Lingonberry Extract as a Photosensitizer for Visible Light Plus Water-Filtered Infrared-A Irradiation.	Klein M, Al-Ahmad A, Follo M, Hellwig E, Vach K, Chrubasik-Hausmann S.	Nutrients	10.3390/nu15234988	2023
Phylogeny	Performance assessment of the Bruker Biotyper MALDI-TOF MS for the identification of difficult-to-identify viridans group streptococci.	Wan T-W, Lee T-F, Chen X-J, Hunag Y-T, Teng L-J, Hsueh P-R, Chiu H-C.	J Clin Microbiol	10.1128/jcm.01143-23	2023
	Nanotopography and oral bacterial adhesion on titanium surfaces: in vitro and in vivo studies.	Schwartz-Filho HO, Martins TR, Sano PR, Araujo MT, Chan DCH, Saldanha NR, Silva KP, Graziano TS, Brandt WC, Torres CVR, Cogo-Muller K.	Braz Oral Res	10.1590/1807-3107bor-2024.vol38.0021	2024
	Screening and characterization of aptamers recognizing the periodontal pathogen Tannerella forsythia.	Mizgalska D, Malicki S, Golda A, Chruscicka-Smaga B, Potempa J.	FEBS Open Bio	10.1002/2211-5463.13772	2024
	Antimicrobial Activity of Methylene Blue Associated with Photodynamic Therapy: In Vitro Study in Multi-Species Oral Biofilm.	Bueno-Silva B, Parma-Garcia J, Frigo L, Suarez LJ, Macedo TT, Uyeda FH, Melo MARDC, Sacco R, Mourao CF, Feres M, Shibli JA, Figueiredo LC.	Pathogens	10.3390/pathogens13040342	2024
	Comparison of In Vitro Biofilm Formation on Titanium and Zirconia Implants.	Chiou LL, Panariello BHD, Hamada Y, Gregory RL, Blanchard S, Duarte S.	Biomed Res Int	10.1155/2023/8728499	2023
	Lactobacillus acidophilus impairs the establishment of pathogens in a subgingival multispecies biofilm.	Bueno MR, Dudu-Silva G, Macedo TT, Gomes APAP, Rodrigues Oliveira Braga A, Aguiar Silva LD, Bueno-Silva B.	Front Dent Med	10.3389/fdmed.2023.1212773	2023
	Toxic cultures: e-cigarettes and the oral microbial exposome.	Beverly ML, Chaudhary PP, Dabdoub SM, Kim S, Chatzakis E, Williamson K, Ganesan SM, Yadav M, Ratley G, D'Souza BN, Myles IA, Kumar PS.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00709-7	2025
	The adhesive PitA pilus protein from the early dental plaque colonizer Streptococcus oralis: expression, purification, crystallization and X-ray diffraction analysis.	Kumari Yadav R, Krishnan V.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x1901642x	2020
	Evaluation of the Microbial Profile on the Polydioxanone Membrane and the Collagen Membrane Exposed to Multi-Species Subgingival Biofilm: An In Vitro Study.	Cintra Moreira MV, Figueiredo LC, da Cunha Melo MAR, Uyeda FH, da Silva LDA, Macedo TT, Sacco R, Mourao CF, Shibli JA, Bueno-Silva B.	Membranes (Basel)	10.3390/membranes13120907	2023
	Oral mitis group streptococci reduce infectivity of influenza A virus via acidification and H2O2 production.	Okahashi N, Sumitomo T, Nakata M, Kuwata H, Kawabata S.	PLoS One	10.1371/journal.pone.0276293	2022
Phylogeny	Quantifying synthetic bacterial community composition with flow cytometry: efficacy in mock communities and challenges in co-cultures.	Mermans F, Chatzigiannidou I, Teughels W, Boon N.	mSystems	10.1128/msystems.01009-24	2025
Metabolism	Phosphatidylcholine Biosynthesis in Mitis Group Streptococci via Host Metabolite Scavenging.	Joyce LR, Guan Z, Palmer KL.	J Bacteriol	10.1128/jb.00495-19	2019
Pathogenicity	Spent culture supernatant of Streptococcus gordonii mitigates inflammation of human periodontal cells and inhibits proliferation of pathogenic oral microbes.	Shu Y, Upara C, Ding Q, Zhu M, Zeng E, Banas JA, Hong L.	J Periodontol	10.1002/jper.22-0333	2023
	Utilizing a naturopathic mouthwash with selective antimicrobial effects against multispecies oral biofilms for prevention of dysbiosis	Siddiqui D, Tsai Y, Giron Bastidas J, Jazaeri M, Kotsakis G.	Front Oral Health		2025
	Identification of Clinically Relevant Streptococcus and Enterococcus Species Based on Biochemical Methods and 16S rRNA, sodA, tuf, rpoB, and recA Gene Sequencing.	Kosecka-Strojek M, Wolska M, Zabicka D, Sadowy E, Miedzobrodzki J.	Pathogens	10.3390/pathogens9110939	2020
Metabolism	Inhibition of Fibrinolysis by Streptococcal Phage Lysin_SM1.	Ji HJ, Zhi Y, Lee JH, Ahn KB, Seo HS, Sullam PM.	mBio	10.1128/mbio.00746-21	2021
	Membrane Phenotypic, Metabolic and Genotypic Adaptations of Streptococcus oralis Strains Destined to Rapidly Develop Stable, High-Level Daptomycin Resistance during Daptomycin Exposures.	Mishra NN, de Paula Baptista R, Tran TT, Lapitan CK, Garcia-de-la-Maria C, Miro JM, Proctor RA, Bayer AS.	Antibiotics (Basel)	10.3390/antibiotics12071083	2023
	Identifying single-strain growth patterns of human gut microbes in response to preterm human milk and formula.	Engevik MA, Stripe LK, Baatz JE, Wagner CL, Chetta KE.	Food Funct	10.1039/d2fo00447j	2022
Pathogenicity	Compounds from Olea europaea and Pistacia lentiscus inhibit oral microbial growth.	Karygianni L, Cecere M, Argyropoulou A, Hellwig E, Skaltsounis AL, Wittmer A, Tchorz JP, Al-Ahmad A.	BMC Complement Altern Med	10.1186/s12906-019-2461-4	2019
	Streptococcus pneumoniae, S. mitis, and S. oralis Produce a Phosphatidylglycerol-Dependent, ltaS-Independent Glycerophosphate-Linked Glycolipid.	Wei Y, Joyce LR, Wall AM, Guan Z, Palmer KL.	mSphere	10.1128/msphere.01099-20	2021
Metabolism	Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity.	Erttmann SF, Gekara NO.	Nat Commun	10.1038/s41467-019-11169-x	2019
Pathogenicity	Anti-biofilm activity of a novel pit and fissure self-adhesive sealant modified with metallic monomers.	Cocco AR, Cuevas-Suarez CE, Liu Y, Lund RG, Piva E, Hwang G.	Biofouling	10.1080/08927014.2020.1748603	2020
	An In Vitro Evaluation of Denture Cleansing Regimens against a Polymicrobial Denture Biofilm Model.	Brown JL, Young T, McKloud E, Butcher MC, Bradshaw D, Pratten JR, Ramage G.	Antibiotics (Basel)	10.3390/antibiotics11010113	2022
	Effect of flavonoids on antimicrobial activity of microorganisms present in dental plaque.	Gutierrez-Venegas G, Gomez-Mora JA, Meraz-Rodriguez MA, Flores-Sanchez MA, Ortiz-Miranda LF.	Heliyon	10.1016/j.heliyon.2019.e03013	2019
	Succession of oral bacterial colonizers on dental implant materials: An in vitro biofilm model.	Siddiqui DA, Fidai AB, Natarajan SG, Rodrigues DC.	Dent Mater	10.1016/j.dental.2021.12.021	2022
Genetics	Resolving Phylogenetic Relationships for Streptococcus mitis and Streptococcus oralis through Core- and Pan-Genome Analyses.	Velsko IM, Perez MS, Richards VP.	Genome Biol Evol	10.1093/gbe/evz049	2019
	Complete Genome Sequence of Streptococcus sp. Strain NPS 308.	Kondo Y, Ogura Y, Sato K, Imamura K, Hoshino T, Nishiguchi M, Hasuwa T, Moriuchi H, Hayashi T, Fujiwara T.	Genome Announc	10.1128/genomea.01349-16	2016
Pathogenicity	Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans.	Hickl J, Argyropoulou A, Sakavitsi ME, Halabalaki M, Al-Ahmad A, Hellwig E, Aligiannis N, Skaltsounis AL, Wittmer A, Vach K, Karygianni L.	PLoS One	10.1371/journal.pone.0207574	2018
	Mung Bean (Vigna radiata (L.) R. Wilczek) from Burkina Faso Used as Antidiabetic, Antioxidant and Antimicrobial Agent.	Kabre JAW, Dah-Nouvlessounon D, Dah-Nouvlessounon D, Hama-Ba F, Agonkoun A, Guinin F, Sina H, Kohonou AN, Tchogou P, Senou M, Savadogo A, Baba-Moussa L.	Plants (Basel)	10.3390/plants11243556	2022
	Impact of Three Nonsurgical, Full-Mouth Periodontal Treatments on Total Bacterial Load and Selected Pathobionts.	Abdelbary MMH, Schittenhelm F, Yekta-Michael SS, Reichert S, Schulz S, Kasaj A, Braun A, Conrads G, Stein JM.	Antibiotics (Basel)	10.3390/antibiotics11050686	2022
	Antibacterial, Hydrophilic Effect and Mechanical Properties of Orthodontic Resin Coated with UV-Responsive Photocatalyst.	Kuroiwa A, Nomura Y, Ochiai T, Sudo T, Nomoto R, Hayakawa T, Kanzaki H, Nakamura Y, Hanada N.	Materials (Basel)	10.3390/ma11060889	2018
	Advances in modeling periodontal host-microbe interactions: insights from organotypic and organ-on-chip systems.	Makkar H, Sriram G.	Lab Chip	10.1039/d4lc00871e	2025
	The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species.	He LY, Le YJ, Guo Z, Li S, Yang XY.	Front Microbiol	10.3389/fmicb.2021.693858	2021
	Biofilm formation on polyetheretherketone and titanium surfaces.	Barkarmo S, Longhorn D, Leer K, Johansson CB, Stenport V, Franco-Tabares S, Kuehne SA, Sammons R.	Clin Exp Dent Res	10.1002/cre2.205	2019
Genetics	Genomic differences between sequence types 1 and 104 of Streptococcus suis Serotype 2.	Kerdsin A, Takeuchi D, Akeda Y, Nakamura S, Gottschalk M, Oishi K.	PeerJ	10.7717/peerj.14144	2022
	Molecular Typing and Antimicrobial Susceptibility Profiles of Streptococcus uberis Isolated from Sheep Milk.	Rosa NM, Dupre I, Azara E, Longheu CM, Tola S.	Pathogens	10.3390/pathogens10111489	2021
Phylogeny	Concatenated 16S rRNA sequence analysis improves bacterial taxonomy.	Paul B.	F1000Res	10.12688/f1000research.128320.3	2022
	Brazilian Red Propolis Is as Effective as Amoxicillin in Controlling Red-Complex of Multispecies Subgingival Mature Biofilm In Vitro.	de Figueiredo KA, da Silva HDP, Miranda SLF, Goncalves FJDS, de Sousa AP, de Figueiredo LC, Feres M, Bueno-Silva B.	Antibiotics (Basel)	10.3390/antibiotics9080432	2020
	Low-Temperature Plasma Short Exposure to Decontaminate Peri-Implantitis-Related Multispecies Biofilms on Titanium Surfaces In Vitro.	Panariello BHD, Mody DP, Eckert GJ, Witek L, Coelho PG, Duarte S.	Biomed Res Int	10.1155/2022/1549774	2022
Metabolism	Hydrogen peroxide contributes to the epithelial cell death induced by the oral mitis group of streptococci.	Okahashi N, Sumitomo T, Nakata M, Sakurai A, Kuwata H, Kawabata S.	PLoS One	10.1371/journal.pone.0088136	2014
Metabolism	Streptococcal H2O2 inhibits IgE-triggered degranulation of RBL-2H3 mast cell/basophil cell line by inducing cell death.	Okahashi N, Nakata M, Hirose Y, Morisaki H, Kataoka H, Kuwata H, Kawabata S.	PLoS One	10.1371/journal.pone.0231101	2020
Pathogenicity	Antibacterial Activity of a Bioactive Tooth-Coating Material Containing Surface Pre-Reacted Glass in a Complex Multispecies Subgingival Biofilm.	Tanaka CJ, Rodrigues JA, Pingueiro JMS, Macedo TT, Feres M, Shibli JA, Bueno-Silva B.	Pharmaceutics	10.3390/pharmaceutics15061727	2023
	Differential immune responses of 3D gingival and periodontal connective tissue equivalents to microbial colonization.	Makkar H, Atkuru S, Tang YL, Sethi T, Lim CT, Tan KS, Sriram G.	J Tissue Eng	10.1177/20417314221111650	2022
Phylogeny	Streptococcus tigurinus is frequent among gtfR-negative Streptococcus oralis isolates and in the human oral cavity, but highly virulent strains are uncommon.	Conrads G, Barth S, Mockel M, Lenz L, van der Linden M, Henne K.	J Oral Microbiol	10.1080/20002297.2017.1307079	2017
Metabolism	Oral streptococci subvert the host innate immune response through hydrogen peroxide.	Tang YL, Sim TS, Tan KS.	Sci Rep	10.1038/s41598-021-04562-4	2022
Metabolism	Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide.	Okahashi N, Nakata M, Kuwata H, Kawabata S.	Infect Immun	10.1128/iai.00134-16	2016
	Genomic and phenotypic characterization of Streptococcus mutans isolates suggests key gene clusters in regulating its interaction with Streptococcus gordonii.	Liu S, Sun Y, Liu Y, Hu F, Xu L, Zheng Q, Wang Q, Zeng G, Zhang K.	Front Microbiol	10.3389/fmicb.2022.945108	2022
	Environment and colonisation sequence are key parameters driving cooperation and competition between Pseudomonas aeruginosa cystic fibrosis strains and oral commensal streptococci.	Whiley RA, Fleming EV, Makhija R, Waite RD.	PLoS One	10.1371/journal.pone.0115513	2015
	Metabolic activity of hydro-carbon-oxo-borate on a multispecies subgingival periodontal biofilm: a short communication.	Shibli JA, Rocha TF, Coelho F, de Oliveira Capote TS, Saska S, Melo MA, Pingueiro JMS, de Faveri M, Bueno-Silva B.	Clin Oral Investig	10.1007/s00784-021-03900-0	2021
	Propolis, Aloe Vera, Green Tea, Cranberry, Calendula, Myrrha and Salvia Properties against Periodontal Microorganisms.	Figueiredo LC, Freitas Figueiredo N, da Cruz DF, Baccelli GT, Sarachini GE, Bueno MR, Feres M, Bueno-Silva B.	Microorganisms	10.3390/microorganisms10112172	2022
	Prevalence, diversity and transferability of the Tn916-Tn1545 family ICE in oral streptococci.	Lunde TM, Hjerde E, Al-Haroni M.	J Oral Microbiol	10.1080/20002297.2021.1896874	2021
Pathogenicity	Deacidification of Cranberry Juice Reduces Its Antibacterial Properties against Oral Streptococci but Preserves Barrier Function and Attenuates the Inflammatory Response of Oral Epithelial Cells.	Pellerin G, Bazinet L, Grenier D.	Foods	10.3390/foods10071634	2021
	High-level antimicrobial efficacy of representative Mediterranean natural plant extracts against oral microorganisms.	Karygianni L, Cecere M, Skaltsounis AL, Argyropoulou A, Hellwig E, Aligiannis N, Wittmer A, Al-Ahmad A.	Biomed Res Int	10.1155/2014/839019	2014
Metabolism	Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts.	Gasiorek A, Dobosz E, Potempa B, Ciaston I, Wilamowski M, Oruba Z, Lamont RJ, Jura J, Potempa J, Koziel J.	mBio	10.1128/mbio.00502-21	2021
	A comprehensive in vitro comparison of the biological and physicochemical properties of bioactive root canal sealers.	Wuersching SN, Diegritz C, Hickel R, Huth KC, Kollmuss M.	Clin Oral Investig	10.1007/s00784-022-04570-2	2022
	Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome.	Seferovic MD, Mohammad M, Pace RM, Engevik M, Versalovic J, Bode L, Haymond M, Aagaard KM.	Sci Rep	10.1038/s41598-020-79022-6	2020
	Commensal Oral Rothia mucilaginosa Produces Enterobactin, a Metal-Chelating Siderophore.	Uranga CC, Arroyo P, Duggan BM, Gerwick WH, Edlund A.	mSystems	10.1128/msystems.00161-20	2020
	Exploring the Antibacterial Activity of Pestalotiopsis spp. under Different Culture Conditions and Their Chemical Diversity Using LC-ESI-Q-TOF-MS.	Aguilar-Perez MM, Torres-Mendoza D, Vasquez R, Rios N, Cubilla-Rios L.	J Fungi (Basel)	10.3390/jof6030140	2020
Pathogenicity	Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity.	Millet N, Solis NV, Swidergall M.	Front Immunol	10.3389/fimmu.2020.555363	2020
	Artificial Intelligence Applied to Improve Scientific Reviews: The Antibacterial Activity of Cistus Plants as Proof of Concept.	Alvarez-Martinez FJ, Borras-Rocher F, Micol V, Barrajon-Catalan E.	Antibiotics (Basel)	10.3390/antibiotics12020327	2023
	Acidogenicity and acid tolerance of Streptococcus oralis and Streptococcus mitis isolated from plaque of healthy and incipient caries teeth.	Banas JA, Zhu M, Dawson DV, Blanchette DR, Drake DR, Gu H, Frost R, McCaulley G, Levy SM.	J Oral Microbiol	10.3402/jom.v8.32940	2016
	Silver Nanoparticles at Biocompatible Dosage Synergistically Increases Bacterial Susceptibility to Antibiotics.	Ipe DS, Kumar PTS, Love RM, Hamlet SM.	Front Microbiol	10.3389/fmicb.2020.01074	2020
	Understanding the Role of Shape and Composition of Star-Shaped Polymers and their Ability to Both Bind and Prevent Bacteria Attachment on Oral Relevant Surfaces.	Mortazavian H, Picquet GA, Lejnieks J, Zaidel LA, Myers CP, Kuroda K.	J Funct Biomater	10.3390/jfb10040056	2019
	Microbial species associated with dental caries found in saliva and in situ after use of self-ligating and conventional brackets.	Bergamo AZN, Matsumoto MAN, Nascimento CD, Andrucioli MCD, Romano FL, Silva RAB, Silva LAB, Nelson-Filho P.	J Appl Oral Sci	10.1590/1678-7757-2018-0426	2019
	Prediction of Antimicrobial and Antioxidant Activities of Mexican Propolis by 1H-NMR Spectroscopy and Chemometrics Data Analysis	Rivero-Cruz J, Rodriguez de San Miguel E, Robles-Obregon S, Hernandez-Espino C, Rivero-Cruz B, Pedraza-Chaverri J, Esturau-Escofet N.	Molecules		2017
	Highly Variable Streptococcus oralis Strains Are Common among Viridans Streptococci Isolated from Primates.	Denapaite D, Rieger M, Kondgen S, Bruckner R, Ochigava I, Kappeler P, Matz-Rensing K, Leendertz F, Hakenbeck R.	mSphere	10.1128/msphere.00041-15	2016
	Probing oral microbial functionality--expression of spxB in plaque samples.	Zhu L, Xu Y, Ferretti JJ, Kreth J.	PLoS One	10.1371/journal.pone.0086685	2014
Metabolism	Effects of Complex DNA and MVs with GTF Extracted from Streptococcus mutans on the Oral Biofilm.	Senpuku H, Nakamura T, Iwabuchi Y, Hirayama S, Nakao R, Ohnishi M.	Molecules	10.3390/molecules24173131	2019
	Differential oxidative stress tolerance of Streptococcus mutans isolates affects competition in an ecological mixed-species biofilm model.	Liu Y, Palmer SR, Chang H, Combs AN, Burne RA, Koo H.	Environ Microbiol Rep	10.1111/1758-2229.12600	2018
	Synthesis and Biological Activity of Highly Cationic Dendrimer Antibiotics.	VanKoten HW, Dlakic WM, Engel R, Cloninger MJ.	Mol Pharm	10.1021/acs.molpharmaceut.6b00628	2016
Pathogenicity	Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity.	Drago L, Bortolin M, Vassena C, Taschieri S, Del Fabbro M.	BMC Microbiol	10.1186/1471-2180-13-47	2013
	Role of Pneumocystis jirovecii in patients with different pulmonary underlying condition using a nested-PCR.	Martinez Lamas L, Perez Rodriguez MT, Alvarez Ramos I, Bouza Soage ME, Figueroa Lamas MP, Alvarez Fernandez M.	Rev Esp Quimioter		2018
	Parallel evolution of Streptococcus pneumoniae and Streptococcus mitis to pathogenic and mutualistic lifestyles.	Kilian M, Riley DR, Jensen A, Bruggemann H, Tettelin H.	mBio	10.1128/mbio.01490-14	2014
	Associations between Periodontal Microbiota and Death Rates.	Chiu CJ, Chang ML, Taylor A.	Sci Rep	10.1038/srep35428	2016
Enzymology	In Vitro Effect of Porphyromonas gingivalis Methionine Gamma Lyase on Biofilm Composition and Oral Inflammatory Response.	Stephen AS, Millhouse E, Sherry L, Aduse-Opoku J, Culshaw S, Ramage G, Bradshaw DJ, Burnett GR, Allaker RP.	PLoS One	10.1371/journal.pone.0169157	2016
Pathogenicity	Reduced Glutathione Mediates Resistance to H2S Toxicity in Oral Streptococci.	Ooi XJ, Tan KS.	Appl Environ Microbiol	10.1128/aem.03946-15	2016
	Interkingdom interactions on the denture surface: Implications for oral hygiene.	Delaney C, O'Donnell LE, Kean R, Sherry L, Brown JL, Calvert G, Nile CJ, Cross L, Bradshaw DJ, Brandt BW, Robertson D, Ramage G.	Biofilm	10.1016/j.bioflm.2019.100002	2019
	Biofilm in Endodontics: In Vitro Cultivation Possibilities, Sonic-, Ultrasonic- and Laser-Assisted Removal Techniques and Evaluation of the Cleaning Efficacy.	Josic U, Mazzitelli C, Maravic T, Fidler A, Breschi L, Mazzoni A.	Polymers (Basel)	10.3390/polym14071334	2022
Metabolism	Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms.	Koo H, Xiao J, Klein MI, Jeon JG.	J Bacteriol	10.1128/jb.01649-09	2010
Metabolism	Differential Utilization of Basic Proline-Rich Glycoproteins during Growth of Oral Bacteria in Saliva.	Zhou Y, Yang J, Zhang L, Zhou X, Cisar JO, Palmer RJ.	Appl Environ Microbiol	10.1128/aem.01111-16	2016
	PCR-Based Identification of Oral Streptococcal Species.	Banas JA, Zhu M, Dawson DV, Cao H, Levy SM.	Int J Dent	10.1155/2016/3465163	2016
Pathogenicity	Effect of smokeless tobacco products on human oral bacteria growth and viability.	Liu M, Jin J, Pan H, Feng J, Cerniglia CE, Yang M, Chen H.	Anaerobe	10.1016/j.anaerobe.2016.10.006	2016
	Antibody binding to Streptococcus mitis and Streptococcus oralis cell fractions.	Wirth KA, Bowden GH, Richmond DA, Sheridan MJ, Cole MF.	Arch Oral Biol	10.1016/j.archoralbio.2007.08.003	2008
	Adverse effects of electronic cigarettes on the disease-naive oral microbiome.	Ganesan SM, Dabdoub SM, Nagaraja HN, Scott ML, Pamulapati S, Berman ML, Shields PG, Wewers ME, Kumar PS.	Sci Adv	10.1126/sciadv.aaz0108	2020
	Modulation of Neutrophil Extracellular Trap and Reactive Oxygen Species Release by Periodontal Bacteria.	Hirschfeld J, White PC, Milward MR, Cooper PR, Chapple ILC.	Infect Immun	10.1128/iai.00297-17	2017
Metabolism	Streptococcus mutans protein synthesis during mixed-species biofilm development by high-throughput quantitative proteomics.	Klein MI, Xiao J, Lu B, Delahunty CM, Yates JR, Koo H.	PLoS One	10.1371/journal.pone.0045795	2012
	PCR-Based Multiple Species Cell Counting for In Vitro Mixed Culture.	Huang R, Zhang J, Yang XF, Gregory RL.	PLoS One	10.1371/journal.pone.0126628	2015
	Candida albicans as an Essential "Keystone" Component within Polymicrobial Oral Biofilm Models?	Young T, Alshanta OA, Kean R, Bradshaw D, Pratten J, Williams C, Woodall C, Ramage G, Brown JL.	Microorganisms	10.3390/microorganisms9010059	2020
	Estimation of bacterial hydrogen sulfide production in vitro.	Basic A, Blomqvist S, Carlen A, Dahlen G.	J Oral Microbiol	10.3402/jom.v7.28166	2015
	Nanotechnology in combating biofilm: A smart and promising therapeutic strategy.	Mohanta YK, Chakrabartty I, Mishra AK, Chopra H, Mahanta S, Avula SK, Patowary K, Ahmed R, Mishra B, Mohanta TK, Saravanan M, Sharma N.	Front Microbiol	10.3389/fmicb.2022.1028086	2022
Metabolism	Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence.	Kharat AS, Denapaite D, Gehre F, Bruckner R, Vollmer W, Hakenbeck R, Tomasz A.	J Bacteriol	10.1128/jb.00628-08	2008
	In vivo biofilm formation on stainless steel bonded retainers during different oral health-care regimens.	Jongsma MA, van der Mei HC, Atema-Smit J, Busscher HJ, Ren Y.	Int J Oral Sci	10.1038/ijos.2014.69	2015
	Endocarditis-associated oral streptococci promote rapid differentiation of monocytes into mature dendritic cells.	Hahn CL, Schenkein HA, Tew JG.	Infect Immun	10.1128/iai.73.8.5015-5021.2005	2005
	Spatial mapping of polymicrobial communities reveals a precise biogeography associated with human dental caries.	Kim D, Barraza JP, Arthur RA, Hara A, Lewis K, Liu Y, Scisci EL, Hajishengallis E, Whiteley M, Koo H.	Proc Natl Acad Sci U S A	10.1073/pnas.1919099117	2020
Phylogeny	Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma.	Pushalkar S, Ji X, Li Y, Estilo C, Yegnanarayana R, Singh B, Li X, Saxena D.	BMC Microbiol	10.1186/1471-2180-12-144	2012
Enzymology	Rapid identification of clinically relevant Enterococcus species by fluorescence in situ hybridization.	Wellinghausen N, Bartel M, Essig A, Poppert S.	J Clin Microbiol	10.1128/jcm.00861-07	2007
Pathogenicity	Influences of trans-trans farnesol, a membrane-targeting sesquiterpenoid, on Streptococcus mutans physiology and survival within mixed-species oral biofilms.	Jeon JG, Pandit S, Xiao J, Gregoire S, Falsetta ML, Klein MI, Koo H.	Int J Oral Sci	10.4248/ijos11038	2011
	Viable Compositional Analysis of an Eleven Species Oral Polymicrobial Biofilm.	Sherry L, Lappin G, O'Donnell LE, Millhouse E, Millington OR, Bradshaw DJ, Axe AS, Williams C, Nile CJ, Ramage G.	Front Microbiol	10.3389/fmicb.2016.00912	2016
Phylogeny	Use of groESL as a target for identification of Abiotrophia, Granulicatella, and Gemella species.	Hung WC, Tseng SP, Chen HJ, Tsai JC, Chang CH, Lee TF, Hsueh PR, Teng LJ.	J Clin Microbiol	10.1128/jcm.00787-10	2010
Enzymology	Identification of Virulence-Associated Properties by Comparative Genome Analysis of Streptococcus pneumoniae, S. pseudopneumoniae, S. mitis, Three S. oralis Subspecies, and S. infantis.	Kilian M, Tettelin H.	mBio	10.1128/mbio.01985-19	2019
Pathogenicity	Cranberry Flavonoids Modulate Cariogenic Properties of Mixed-Species Biofilm through Exopolysaccharides-Matrix Disruption.	Kim D, Hwang G, Liu Y, Wang Y, Singh AP, Vorsa N, Koo H.	PLoS One	10.1371/journal.pone.0145844	2015
	Characterization of a Signaling System in Streptococcus mitis That Mediates Interspecies Communication with Streptococcus pneumoniae.	Junges R, Sturod K, Salvadori G, Amdal HA, Chen T, Petersen FC.	Appl Environ Microbiol	10.1128/aem.02297-18	2019
	Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw.	Pushalkar S, Li X, Kurago Z, Ramanathapuram LV, Matsumura S, Fleisher KE, Glickman R, Yan W, Li Y, Saxena D.	Int J Oral Sci	10.1038/ijos.2014.46	2014
Metabolism	The exopolysaccharide matrix modulates the interaction between 3D architecture and virulence of a mixed-species oral biofilm.	Xiao J, Klein MI, Falsetta ML, Lu B, Delahunty CM, Yates JR, Heydorn A, Koo H.	PLoS Pathog	10.1371/journal.ppat.1002623	2012
	Subgingival microbiota in adult Down syndrome periodontitis.	Khocht A, Yaskell T, Janal M, Turner BF, Rams TE, Haffajee AD, Socransky SS.	J Periodontal Res	10.1111/j.1600-0765.2011.01459.x	2012
Pathogenicity	Effects of three different infant dentifrices on biofilms and oral microorganisms.	Modesto A, Lima KC, de Uzeda M.	J Clin Pediatr Dent		2000
Metabolism	Capsular Polysaccharide Expression in Commensal Streptococcus Species: Genetic and Antigenic Similarities to Streptococcus pneumoniae.	Skov Sorensen UB, Yao K, Yang Y, Tettelin H, Kilian M.	mBio	10.1128/mbio.01844-16	2016
	Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model.	Soares GM, Teles F, Starr JR, Feres M, Patel M, Martin L, Teles R.	Antimicrob Agents Chemother	10.1128/aac.04974-14	2015
	Complete structure of the adhesin receptor polysaccharide of Streptococcus oralis ATCC 55229 (Streptococcus sanguis H1).	Glushka J, Cassels FJ, Carlson RW, van Halbeek H.	Biochemistry	10.1021/bi00159a014	1992
Phylogeny	Differentiation of Streptococcus pneumoniae conjunctivitis outbreak isolates by matrix-assisted laser desorption ionization-time of flight mass spectrometry.	Williamson YM, Moura H, Woolfitt AR, Pirkle JL, Barr JR, Carvalho Mda G, Ades EP, Carlone GM, Sampson JS.	Appl Environ Microbiol	10.1128/aem.00791-08	2008
	Monitoring the prevalence of viable and dead cariogenic bacteria in oral specimens and in vitro biofilms by qPCR combined with propidium monoazide.	Yasunaga A, Yoshida A, Morikawa K, Maki K, Nakamura S, Soh I, Awano S, Ansai T.	BMC Microbiol	10.1186/1471-2180-13-157	2013
	Complete structure of the cell surface polysaccharide of Streptococcus oralis ATCC 10557: a receptor for lectin-mediated interbacterial adherence.	Abeygunawardana C, Bush CA, Cisar JO.	Biochemistry	10.1021/bi00240a025	1991
	Antibiotic effects on bacterial profile in osteonecrosis of the jaw.	Ji X, Pushalkar S, Li Y, Glickman R, Fleisher K, Saxena D.	Oral Dis	10.1111/j.1601-0825.2011.01848.x	2012
Pathogenicity	Photoactive porphyrin derivative with broad-spectrum activity against oral pathogens In vitro.	Rovaldi CR, Pievsky A, Sole NA, Friden PM, Rothstein DM, Spacciapoli P.	Antimicrob Agents Chemother	10.1128/aac.44.12.3364-3367.2000	2000
	Characterization of a Streptococcus sp.-Veillonella sp. community micromanipulated from dental plaque.	Chalmers NI, Palmer RJ, Cisar JO, Kolenbrander PE.	J Bacteriol	10.1128/jb.00983-08	2008
	Molecular approaches for viable bacterial population and transcriptional analyses in a rodent model of dental caries.	Klein MI, Scott-Anne KM, Gregoire S, Rosalen PL, Koo H.	Mol Oral Microbiol	10.1111/j.2041-1014.2012.00647.x	2012
Phylogeny	Molecular analysis of oral and respiratory bacterial species associated with ventilator-associated pneumonia.	Bahrani-Mougeot FK, Paster BJ, Coleman S, Barbuto S, Brennan MT, Noll J, Kennedy T, Fox PC, Lockhart PB.	J Clin Microbiol	10.1128/jcm.01963-06	2007
	QC-Chain: fast and holistic quality control method for next-generation sequencing data.	Zhou Q, Su X, Wang A, Xu J, Ning K.	PLoS One	10.1371/journal.pone.0060234	2013
Enzymology	Rapid and reliable identification of Streptococcus pneumoniae isolates by pneumolysin-mediated agglutination.	Cima-Cabal MD, Vazquez F, de los Toyos JR, Mendez FJ.	J Clin Microbiol	10.1128/jcm.37.6.1964-1966.1999	1999
Pathogenicity	Molecular Assay for Detection of Genetic Markers Associated with Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae.	Peterson SW, Martin I, Demczuk W, Bharat A, Hoang L, Wylie J, Allen V, Lefebvre B, Tyrrell G, Horsman G, Haldane D, Garceau R, Wong T, Mulvey MR.	J Clin Microbiol	10.1128/jcm.00493-15	2015
	An in vitro biofilm model of subgingival plaque.	Walker C, Sedlacek MJ.	Oral Microbiol Immunol	10.1111/j.1399-302x.2007.00336.x	2007
Enzymology	Oral streptococci with genetic determinants similar to the glucosyltransferase regulatory gene, rgg.	Vickerman MM, Sulavik MC, Clewell DB.	Infect Immun	10.1128/iai.63.11.4524-4527.1995	1995
	Microbial Biofilm Decontamination on Dental Implant Surfaces: A Mini Review.	Dhaliwal JS, Abd Rahman NA, Ming LC, Dhaliwal SKS, Knights J, Albuquerque Junior RF.	Front Cell Infect Microbiol	10.3389/fcimb.2021.736186	2021
Enzymology	Quantitative detection of Moraxella catarrhalis in nasopharyngeal secretions by real-time PCR.	Greiner O, Day PJ, Altwegg M, Nadal D.	J Clin Microbiol	10.1128/jcm.41.4.1386-1390.2003	2003
Enzymology	Genetic profiling of the oral microbiota associated with severe early-childhood caries.	Li Y, Ge Y, Saxena D, Caufield PW.	J Clin Microbiol	10.1128/jcm.01622-06	2007
	Phosphorylcholine-dependent cross-reactivity between dental plaque bacteria and oxidized low-density lipoproteins.	Schenkein HA, Berry CR, Purkall D, Burmeister JA, Brooks CN, Tew JG.	Infect Immun	10.1128/iai.69.11.6612-6617.2001	2001
	Humoral immunity to commensal oral bacteria in human infants: salivary secretory immunoglobulin A antibodies reactive with Streptococcus mitis biovar 1, Streptococcus oralis, Streptococcus mutans, and Enterococcus faecalis during the first two years of life.	Cole MF, Bryan S, Evans MK, Pearce CL, Sheridan MJ, Sura PA, Wientzen RL, Bowden GH.	Infect Immun	10.1128/iai.67.4.1878-1886.1999	1999
Pathogenicity	Nanotechnology-based drug delivery systems for control of microbial biofilms: a review.	Dos Santos Ramos MA, Da Silva PB, Sposito L, De Toledo LG, Bonifacio BV, Rodero CF, Dos Santos KC, Chorilli M, Bauab TM.	Int J Nanomedicine	10.2147/ijn.s146195	2018
Metabolism	Periodontal pathogens produce quorum sensing signal molecules.	Frias J, Olle E, Alsina M.	Infect Immun	10.1128/iai.69.5.3431-3434.2001	2001
Metabolism	Regulation of bacteriocin production and cell death by the VicRK signaling system in Streptococcus mutans.	Senadheera DB, Cordova M, Ayala EA, Chavez de Paz LE, Singh K, Downey JS, Svensater G, Goodman SD, Cvitkovitch DG.	J Bacteriol	10.1128/jb.06071-11	2012
Phylogeny	groESL sequence determination, phylogenetic analysis, and species differentiation for viridans group streptococci.	Teng LJ, Hsueh PR, Tsai JC, Chen PW, Hsu JC, Lai HC, Lee CN, Ho SW.	J Clin Microbiol	10.1128/jcm.40.9.3172-3178.2002	2002
Phylogeny	Evaluation of a rapid direct assay for identification of bacteria and the mec A and van genes from positive-testing blood cultures.	Eigner U, Weizenegger M, Fahr AM, Witte W.	J Clin Microbiol	10.1128/jcm.43.10.5256-5262.2005	2005
Enzymology	Mannosidase production by viridans group streptococci.	Homer KA, Roberts G, Byers HL, Tarelli E, Whiley RA, Philpott-Howard J, Beighton D.	J Clin Microbiol	10.1128/jcm.39.3.995-1001.2001	2001
	The vaginal microflora in relation to gingivitis.	Persson R, Hitti J, Verhelst R, Vaneechoutte M, Persson R, Hirschi R, Weibel M, Rothen M, Temmerman M, Paul K, Eschenbach D.	BMC Infect Dis	10.1186/1471-2334-9-6	2009
Metabolism	The role of hydrogen peroxide in environmental adaptation of oral microbial communities.	Zhu L, Kreth J.	Oxid Med Cell Longev	10.1155/2012/717843	2012
Enzymology	Identification of clinically relevant viridans group streptococci by sequence analysis of the 16S-23S ribosomal DNA spacer region.	Chen CC, Teng LJ, Chang TC.	J Clin Microbiol	10.1128/jcm.42.6.2651-2657.2004	2004
Enzymology	Semiquantitative detection by real-time PCR of Aspergillus fumigatus in bronchoalveolar lavage fluids and tissue biopsy specimens from patients with invasive aspergillosis.	Rantakokko-Jalava K, Laaksonen S, Issakainen J, Vauras J, Nikoskelainen J, Viljanen MK, Salonen J.	J Clin Microbiol	10.1128/jcm.41.9.4304-4311.2003	2003
Enzymology	Identity of streptococcal blood isolates and oral isolates from two patients with infective endocarditis.	Fiehn NE, Gutschik E, Larsen T, Bangsborg JM.	J Clin Microbiol	10.1128/jcm.33.5.1399-1401.1995	1995
	Streptococcus salivarius fimbriae are composed of a glycoprotein containing a repeated motif assembled into a filamentous nondissociable structure.	Levesque C, Vadeboncoeur C, Chandad F, Frenette M.	J Bacteriol	10.1128/jb.183.9.2724-2732.2001	2001
Phylogeny	Use of restriction fragment polymorphism analysis of rRNA genes to assign species to unknown clinical isolates of oral viridans streptococci.	Rudney JD, Larson CJ.	J Clin Microbiol	10.1128/jcm.32.2.437-443.1994	1994
Enzymology	Development of conventional and real-time PCR assays for detection of Legionella DNA in respiratory specimens.	Rantakokko-Jalava K, Jalava J.	J Clin Microbiol	10.1128/jcm.39.8.2904-2910.2001	2001
Metabolism	Physiological and serological variation in Streptococcus mitis biovar 1 from the human oral cavity during the first year of life.	Kirchherr JL, Bowden GH, Cole MF, Kawamura Y, Richmond DA, Sheridan MJ, Wirth KA.	Arch Oral Biol	10.1016/j.archoralbio.2006.07.003	2007
	Demonstration of human immunoglobulin G Fc-binding activity in oral bacteria.	Grenier D, Michaud J.	Clin Diagn Lab Immunol	10.1128/cdli.1.2.247-249.1994	1994
Enzymology	Distribution of proteins similar to IIIManH and IIIManL of the Streptococcus salivarius phosphoenolpyruvate:mannose-glucose phosphotransferase system among oral and nonoral bacteria.	Pelletier M, Frenette M, Vadeboncoeur C.	J Bacteriol	10.1128/jb.177.9.2270-2275.1995	1995
Phylogeny	Species identification of oral viridans streptococci by restriction fragment polymorphism analysis of rRNA genes.	Rudney JD, Larson CJ.	J Clin Microbiol	10.1128/jcm.31.9.2467-2473.1993	1993
	Propionate Attenuates Growth of Oral Streptococci through Enhancing Methionine Biosynthesis.	Park T, Im J, Kim AR, Lee D, Jeong S, Yun CH, Han SH.	J Microbiol Biotechnol	10.4014/jmb.2205.05037	2022
Genetics	Bacteriocin Producing Streptococcus agalactiae Strains Isolated from Bovine Mastitis in Brazil.	Vidal Amaral JR, Juca Ramos RT, Almeida Araujo F, Bentes Kato R, Figueira Aburjaile F, de Castro Soares S, Goes-Neto A, Matiuzzi da Costa M, Azevedo V, Brenig B, Soares de Oliveira S, Soares Rosado A.	Microorganisms	10.3390/microorganisms10030588	2022
	Fluorescence Imaging of Streptococcus pneumoniae with the Helix pomatia agglutinin (HPA) As a Potential, Rapid Diagnostic Tool.	Domenech M, Garcia E.	Front Microbiol	10.3389/fmicb.2017.01333	2017
Phylogeny	recA-based PCR assay for accurate differentiation of Streptococcus pneumoniae from other viridans streptococci.	Zbinden A, Kohler N, Bloemberg GV.	J Clin Microbiol	10.1128/jcm.01450-10	2011
Phylogeny	Identification of clinical isolates of alpha-hemolytic streptococci by 16S rRNA gene sequencing, matrix-assisted laser desorption ionization-time of flight mass spectrometry using MALDI Biotyper, and conventional phenotypic methods: a comparison.	Davies AP, Reid M, Hadfield SJ, Johnston S, Mikhail J, Harris LG, Jenkinson HF, Berry N, Lewis AM, El-Bouri K, Mack D.	J Clin Microbiol	10.1128/jcm.02387-12	2012
Pathogenicity	In vitro destruction of Streptococcus pneumoniae biofilms with bacterial and phage peptidoglycan hydrolases.	Domenech M, Garcia E, Moscoso M.	Antimicrob Agents Chemother	10.1128/aac.00492-11	2011
Phylogeny	Streptococcus pseudopneumoniae identification by pherotype: a method to assist understanding of a potentially emerging or overlooked pathogen.	Leung MH, Ling CL, Ciesielczuk H, Lockwood J, Thurston S, Charalambous BM, Gillespie SH.	J Clin Microbiol	10.1128/jcm.00131-12	2012
	Distribution and genetic diversity of the ABC transporter lipoproteins PiuA and PiaA within Streptococcus pneumoniae and related streptococci.	Whalan RH, Funnell SG, Bowler LD, Hudson MJ, Robinson A, Dowson CG.	J Bacteriol	10.1128/jb.188.3.1031-1038.2006	2006
	Population structure of Streptococcus oralis.	Do T, Jolley KA, Maiden MCJ, Gilbert SC, Clark D, Wade WG, Beighton D.	Microbiology (Reading)	10.1099/mic.0.027284-0	2009
Phylogeny	Use of quantitative PCR and culture methods to characterize ecological flux in bacterial biofilms.	Dalwai F, Spratt DA, Pratten J.	J Clin Microbiol	10.1128/jcm.01131-07	2007
	Potential role of Veillonella spp. as a reservoir of transferable tetracycline resistance in the oral cavity.	Ready D, Pratten J, Roberts AP, Bedi R, Mullany P, Wilson M.	Antimicrob Agents Chemother	10.1128/aac.00217-06	2006
	Antibiotic ResistanceCan Be Enhanced in Gram-Positive Species by Some Biocidal Agents Used for Disinfection.	Kampf G.	Antibiotics (Basel)	10.3390/antibiotics8010013	2019
Pathogenicity	Antimicrobial activity of two South African honeys produced from indigenous Leucospermum cordifolium and Erica species on selected micro-organisms.	Basson NJ, Grobler SR.	BMC Complement Altern Med	10.1186/1472-6882-8-41	2008
	Population density profiles of nasopharyngeal carriage of 5 bacterial species in pre-school children measured using quantitative PCR offer potential insights into the dynamics of transmission.	Thors V, Morales-Aza B, Pidwill G, Vipond I, Muir P, Finn A.	Hum Vaccin Immunother	10.1080/21645515.2015.1090069	2016
	Identification of the psaA gene, coding for pneumococcal surface adhesin A, in viridans group streptococci other than Streptococcus pneumoniae.	Jado I, Fenoll A, Casal J, Perez A.	Clin Diagn Lab Immunol	10.1128/cdli.8.5.895-898.2001	2001
Pathogenicity	Genetic characterization of optochin-susceptible viridans group streptococci.	Martin-Galiano AJ, Balsalobre L, Fenoll A, de la Campa AG.	Antimicrob Agents Chemother	10.1128/aac.47.10.3187-3194.2003	2003
	Viridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniae.	Balsalobre L, Ferrandiz MJ, Linares J, Tubau F, de la Campa AG.	Antimicrob Agents Chemother	10.1128/aac.47.7.2072-2081.2003	2003
Pathogenicity	Drug efflux and parC mutations are involved in fluoroquinolone resistance in viridans group streptococci.	Ferrandiz MJ, Oteo J, Aracil B, Gomez-Garces JL, De La Campa AG.	Antimicrob Agents Chemother	10.1128/aac.43.10.2520	1999
Pathogenicity	New mutations and horizontal transfer of rpoB among rifampin-resistant Streptococcus pneumoniae from four Spanish hospitals.	Ferrandiz MJ, Ardanuy C, Linares J, Garcia-Arenzana JM, Cercenado E, Fleites A, de la Campa AG, Spanish Pneumococcal Infection Study Network.	Antimicrob Agents Chemother	10.1128/aac.49.6.2237-2245.2005	2005
	Genetic relationships between clinical isolates of Streptococcus pneumoniae, Streptococcus oralis, and Streptococcus mitis: characterization of "Atypical" pneumococci and organisms allied to S. mitis harboring S. pneumoniae virulence factor-encoding genes.	Whatmore AM, Efstratiou A, Pickerill AP, Broughton K, Woodard G, Sturgeon D, George R, Dowson CG.	Infect Immun	10.1128/iai.68.3.1374-1382.2000	2000
Enzymology	pH gradient and distribution of streptococci, lactobacilli, prevotellae, and fusobacteria in carious dentine.	Kianoush N, Nguyen KA, Browne GV, Simonian M, Hunter N.	Clin Oral Investig	10.1007/s00784-013-1009-0	2014
Metabolism	Identification of a secreted cholesterol-dependent cytolysin (mitilysin) from Streptococcus mitis.	Jefferies J, Nieminen L, Kirkham LA, Johnston C, Smith A, Mitchell TJ.	J Bacteriol	10.1128/jb.01092-06	2007
Pathogenicity	Fluoroquinolone resistance mutations in the parC, parE, and gyrA genes of clinical isolates of viridans group streptococci.	Gonzalez I, Georgiou M, Alcaide F, Balas D, Linares J, de la Campa AG.	Antimicrob Agents Chemother	10.1128/aac.42.11.2792	1998
Pathogenicity	Composition and susceptibility to chlorhexidine of multispecies biofilms of oral bacteria.	Pratten J, Barnett P, Wilson M.	Appl Environ Microbiol	10.1128/aem.64.9.3515-3519.1998	1998
Phylogeny	Sequetyping: serotyping Streptococcus pneumoniae by a single PCR sequencing strategy.	Leung MH, Bryson K, Freystatter K, Pichon B, Edwards G, Charalambous BM, Gillespie SH.	J Clin Microbiol	10.1128/jcm.06384-11	2012
	Use of quantitative 16S ribosomal DNA detection for diagnosis of central vascular catheter-associated bacterial infection.	Warwick S, Wilks M, Hennessy E, Powell-Tuck J, Small M, Sharp J, Millar MR.	J Clin Microbiol	10.1128/jcm.42.4.1402-1408.2004	2004
Phylogeny	Description and evaluation of the semiautomated 4-hour rapid ID 32 Strep method for identification of streptococci and members of related genera.	Freney J, Bland S, Etienne J, Desmonceaux M, Boeufgras JM, Fleurette J.	J Clin Microbiol	10.1128/jcm.30.10.2657-2661.1992	1992
Metabolism	Homeologous recombination and mismatch repair during transformation in Streptococcus pneumoniae: saturation of the Hex mismatch repair system.	Humbert O, Prudhomme M, Hakenbeck R, Dowson CG, Claverys JP.	Proc Natl Acad Sci U S A	10.1073/pnas.92.20.9052	1995
	Eight-plex PCR and liquid-array detection of bacterial and viral pathogens in cerebrospinal fluid from patients with suspected meningitis.	Boving MK, Pedersen LN, Moller JK.	J Clin Microbiol	10.1128/jcm.01966-08	2009
Enzymology	A comprehensive genetic study of streptococcal immunoglobulin A1 proteases: evidence for recombination within and between species.	Poulsen K, Reinholdt J, Jespersgaard C, Boye K, Brown TA, Hauge M, Kilian M.	Infect Immun	10.1128/iai.66.1.181-190.1998	1998
	Barriers to genetic exchange between bacterial species: Streptococcus pneumoniae transformation.	Majewski J, Zawadzki P, Pickerill P, Cohan FM, Dowson CG.	J Bacteriol	10.1128/jb.182.4.1016-1023.2000	2000
	Horizontal transfer of parC and gyrA in fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae.	Ferrandiz MJ, Fenoll A, Linares J, De La Campa AG.	Antimicrob Agents Chemother	10.1128/aac.44.4.840-847.2000	2000
Enzymology	Identification of Abiotrophia adiacens and Abiotrophia defectiva by 16S rRNA gene PCR and restriction fragment length polymorphism analysis.	Ohara-Nemoto Y, Tajika S, Sasaki M, Kaneko M.	J Clin Microbiol	10.1128/jcm.35.10.2458-2463.1997	1997
Enzymology	Molecular characterization of cap3A, a gene from the operon required for the synthesis of the capsule of Streptococcus pneumoniae type 3: sequencing of mutations responsible for the unencapsulated phenotype and localization of the capsular cluster on the pneumococcal chromosome.	Arrecubieta C, Lopez R, Garcia E.	J Bacteriol	10.1128/jb.176.20.6375-6383.1994	1994
Enzymology	Detection of Streptococcus pneumoniae in sputum samples by PCR.	Gillespie SH, Ullman C, Smith MD, Emery V.	J Clin Microbiol	10.1128/jcm.32.5.1308-1311.1994	1994
Enzymology	Molecular peculiarities of the lytA gene isolated from clinical pneumococcal strains that are bile insoluble.	Obregon V, Garcia P, Garcia E, Fenoll A, Lopez R, Garcia JL.	J Clin Microbiol	10.1128/jcm.40.7.2545-2554.2002	2002
	EJ-1, a temperate bacteriophage of Streptococcus pneumoniae with a Myoviridae morphotype.	Diaz E, Lopez R, Garcia JL.	J Bacteriol	10.1128/jb.174.17.5516-5525.1992	1992
Phylogeny	Comparison of phenotypic characteristics, DNA-DNA hybridization results, and results with a commercial rapid biochemical and enzymatic reaction system for identification of viridans group streptococci.	Kikuchi K, Enari T, Totsuka K, Shimizu K.	J Clin Microbiol	10.1128/jcm.33.5.1215-1222.1995	1995
	Role of the major pneumococcal autolysin in the atypical response of a clinical isolate of Streptococcus pneumoniae.	Diaz E, Lopez R, Garcia JL.	J Bacteriol	10.1128/jb.174.17.5508-5515.1992	1992
Phylogeny	Classification and identification of the viridans streptococci.	Coykendall AL.	Clin Microbiol Rev	10.1128/cmr.2.3.315	1989
	Evaluation of several biochemical and molecular techniques for identification of Streptococcus pneumoniae and Streptococcus pseudopneumoniae and their detection in respiratory samples.	Wessels E, Schelfaut JJ, Bernards AT, Claas EC.	J Clin Microbiol	10.1128/jcm.06609-11	2012
	Bactericidal nanotopography of titanium dental implants: in vitro and in vivo studies.	Gil J, Sanz M.	Clin Oral Investig	10.1007/s00784-025-06424-z	2025
	Antibacterial Effect of Combined Electrolytic and Chemical Decontamination Methods on Dental Implant Surfaces: In Vitro Study.	Odeh V, Virto L, Garcia-Quismondo E, Herrera D, Palma J, Sanz M.	Clin Oral Implants Res	10.1111/clr.70012	2025
Pathogenicity	Antimicrobial activity of red wine and oenological extracts against periodontal pathogens in a validated oral biofilm model.	Sanchez MC, Sanchez MC, Ribeiro-Vidal H, Esteban-Fernandez A, Bartolome B, Figuero E, Moreno-Arribas MV, Sanz M, Herrera D.	BMC Complement Altern Med	10.1186/s12906-019-2533-5	2019
	Method to quantify live and dead cells in multi-species oral biofilm by real-time PCR with propidium monoazide.	Alvarez G, Gonzalez M, Isabal S, Blanc V, Leon R.	AMB Express	10.1186/2191-0855-3-1	2013
Enzymology	Streptococcus mutans isolated from a 4-year-old girl diagnosed with infective endocarditis.	Kondo Y, Hoshino T, Ogawa M, Hidaka K, Hasuwa T, Moriuchi H, Fujiwara T.	Clin Exp Dent Res	10.1002/cre2.220	2019
	Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan.	Yabuuchi S, Oiki S, Minami S, Takase R, Watanabe D, Hashimoto W.	Sci Rep	10.1038/s41598-022-14857-9	2022
Enzymology	Neuraminidase-producing oral mitis group streptococci potentially contribute to influenza viral infection and reduction in antiviral efficacy of zanamivir.	Kamio N, Imai K, Shimizu K, Cueno ME, Tamura M, Saito Y, Ochiai K.	Cell Mol Life Sci	10.1007/s00018-014-1669-1	2015
	Surface properties of dental zirconia ceramics affected by ultrasonic scaling and low-temperature degradation.	Nakazawa K, Nakamura K, Harada A, Shirato M, Inagaki R, Ortengren U, Kanno T, Niwano Y, Egusa H.	PLoS One	10.1371/journal.pone.0203849	2018
	A New Approach Against Some Oral Pathogenic Bacteria Using a Chimeric Antimicrobial Peptide Derived from the Camel Milk; Lactoferrampin - Lactoferricin Chimer.	Mohammadipour HS, Akbari M, Tanhaeian A, Pourgonabadi S, Sekandari S, Karimian E	Curr Drug Discov Technol	10.2174/1570163817999201111193507	2021
	The effective and safe method for preventing and treating bacteria-induced dental diseases by herbal plants and a recombinant peptide.	Tanhaieian A, Pourgonabadi S, Akbari M, Mohammadipour HS	J Clin Exp Dent	10.4317/jced.55717	2020
Transcriptome	Top-Down LESA Mass Spectrometry Protein Analysis of Gram-Positive and Gram-Negative Bacteria.	Kocurek KI, Stones L, Bunch J, May RC, Cooper HJ	J Am Soc Mass Spectrom	10.1007/s13361-017-1718-8	2017
Pathogenicity	Effective oral health in infective endocarditis: efficacy of high-street mouthwashes against the viridans group streptococci.	Elshibly A, Coulter WA, Millar BC, Prendergast BD, Thornhill M, Irwin C, Goldsmith CE, Moore JE	J Investig Clin Dent	10.1111/jicd.12088	2014
Pathogenicity	Inhibitory effect on in vitro Streptococcus oralis biofilm of a soda-lime glass containing silver nanoparticles coating on titanium alloy.	Cabal B, Cafini F, Esteban-Tejeda L, Alou L, Bartolome JF, Sevillano D, Lopez-Piriz R, Torrecillas R, Moya JS	PLoS One	10.1371/journal.pone.0042393	2012
Metabolism	Mitis group streptococci express variable pilus islet 2 pili.	Zahner D, Gandhi AR, Yi H, Stephens DS	PLoS One	10.1371/journal.pone.0025124	2011
Biotechnology	Lactobacillus fermentum ACA-DC 179 displays probiotic potential in vitro and protects against trinitrobenzene sulfonic acid (TNBS)-induced colitis and Salmonella infection in murine models.	Zoumpopoulou G, Foligne B, Christodoulou K, Grangette C, Pot B, Tsakalidou E	Int J Food Microbiol	10.1016/j.ijfoodmicro.2007.10.013	2007
Pathogenicity	Inhibition of bacterial adherence to saliva-coated through plant lectins.	Oliveira MR, Napimoga MH, Cogo K, Goncalves RB, Macedo ML, Freire MG, Groppo FC	J Oral Sci	10.2334/josnusd.49.141	2007
Metabolism	Utilization and acid production of beta-galactosyllactose by oral streptococci and human dental plaque.	Hata S, Hata H, Kanou N, Saito T, Kamiyama K, Mayanagi H	Oral Microbiol Immunol	10.1034/j.1399-302x.2001.160110.x	2001
Enzymology	Identification and characterization of IS1381, a new insertion sequence in Streptococcus pneumoniae.	Sanchez-Beato AR, Garcia E, Lopez R, Garcia JL	J Bacteriol	10.1128/jb.179.7.2459-2463.1997	1997
Metabolism	Possible role of a choline-containing teichoic acid in the maintenance of normal cell shape and physiology in Streptococcus oralis.	Horne DS, Tomasz A	J Bacteriol	10.1128/jb.175.6.1717-1722.1993	1993
Enzymology	Infection of Streptococcus oralis NCTC 11427 by pneumococcal phages.	Ronda C, Garcia JL, Lopez R	FEMS Microbiol Lett	10.1016/0378-1097(89)90389-3	1989
Metabolism	Characterization of genetic transformation in Streptococcus oralis NCTC 11427: expression of the pneumococcal amidase in S. oralis using a new shuttle vector.	Ronda C, Garcia JL, Lopez R	Mol Gen Genet	10.1007/BF00331302	1988
Enzymology	Construction of a DNA probe for the specific identification of Streptococcus oralis.	Schmidhuber S, Ludwig W, Schleifer KH	J Clin Microbiol	10.1128/jcm.26.5.1042-1044.1988	1988
Genetics	Noncontiguous finished genome sequence and description of Streptococcus timonensis sp. nov. isolated from the human stomach.	Ricaboni D, Mailhe M, Lagier JC, Michelle C, Armstrong N, Bittar F, Vitton V, Benezech A, Raoult D, Million M.	New Microbes New Infect	10.1016/j.nmni.2016.11.013	2017
Phylogeny	Streptococcus oricebi sp. nov., isolated from the oral cavity of tufted capuchin.	Saito M, Shinozaki-Kuwahara N, Hirasawa M, Takada K	Int J Syst Evol Microbiol	10.1099/ijsem.0.000834	2015

References

#8975	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20627
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#42198	; Curators of the CIP;
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#67771	Korean Collection for Type Cultures (KCTC) ; Curators of the KCTC;
#68381	Automatically annotated from API rID32STR .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#121429	Collection of Institut Pasteur ; Curators of the CIP; CIP 102922
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptococcus oralis subsp. oralis (DSM 20627, ATCC 35037, KCTC 13048)

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