Streptococcus sobrinus (CCUG 21019, ATCC 27351, NCTC 10921)

Name: Streptococcus sobrinus (CCUG 21019, ATCC 27351, NCTC 10921)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 143690

Type strain

Culture col. no. CCUG 21019 ATCC 27351 NCTC 10921 CCM 7556

NCBI tax ID(s) 1310

Special Collections CCUG

Links

Streptococcus sobrinus CCUG 21019 is a bacterium that was isolated from Hamster inoculated with human dental plaque.

genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 8081

LMG 14640,ATCC 27351,CCUG 21019,NCTC 10921,KCTC 3289,NRRL B-14554

@ref 20215

Last LPSN update 2026-05-29 08:40:30

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Streptococcaceae

Genus Streptococcus

Species Streptococcus sobrinus

Full scientific name Streptococcus sobrinus (ex Coykendall 1974) Coykendall 1983

Synonyms (1)

"Streptococcus mutans subsp. sobrinus"

BacDive ID	Other strains from **Streptococcus sobrinus** (10)	Type strain
14769	S. sobrinus SL1, DSM 20742, ATCC 33478, CCM 6070, CCUG ... (type strain)
14768	S. sobrinus 25859, DSM 20381
135689	S. sobrinus CCUG 27644, CIP 74.16
145042	S. sobrinus CCUG 27507, NCTC 11061
145283	S. sobrinus CCUG 28076
145284	S. sobrinus CCUG 28077
148341	S. sobrinus CCUG 35254
152127	S. sobrinus CCUG 45855 B
154039	S. sobrinus CCUG 52073
165122	S. sobrinus JCM 5176

Morphology

Culture and growth conditions

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	facultative anaerobe	92.561

Spore formation

@ref	Spore formation	Confidence
125439		99.7
125438		90.5

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68381	40585 ChEBI	alpha-cyclodextrin	-	builds acid from	from API rID32STR
68381	29016 ChEBI	arginine	-	hydrolysis	from API rID32STR
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
68381	18333 ChEBI	D-arabitol	-	builds acid from	from API rID32STR
68381	16899 ChEBI	D-mannitol	+	builds acid from	from API rID32STR
68380	16024 ChEBI	D-mannose	+	fermentation	from API rID32A
68381	16988 ChEBI	D-ribose	-	builds acid from	from API rID32STR
68381	16443 ChEBI	D-tagatose	-	builds acid from	from API rID32STR
68381	28087 ChEBI	glycogen	-	builds acid from	from API rID32STR
68381	606565 ChEBI	hippurate	-	hydrolysis	from API rID32STR
68381	30849 ChEBI	L-arabinose	-	builds acid from	from API rID32STR
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68381	17716 ChEBI	lactose	-	builds acid from	from API rID32STR
68381	17306 ChEBI	maltose	+	builds acid from	from API rID32STR
68381	6731 ChEBI	melezitose	-	builds acid from	from API rID32STR
68381	28053 ChEBI	melibiose	-	builds acid from	from API rID32STR
68381	320055 ChEBI	methyl beta-D-glucopyranoside	-	builds acid from	from API rID32STR
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
68381	27941 ChEBI	pullulan	-	builds acid from	from API rID32STR
68381	16634 ChEBI	raffinose	-	builds acid from	from API rID32STR
68380	16634 ChEBI	raffinose	-	fermentation	from API rID32A
68381	30911 ChEBI	sorbitol	-	builds acid from	from API rID32STR
68381	17992 ChEBI	sucrose	+	builds acid from	from API rID32STR
68381	27082 ChEBI	trehalose	+	builds acid from	from API rID32STR
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68381	16199 ChEBI	urea	-	hydrolysis	from API rID32STR
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68381	15688 ChEBI	acetoin		from API rID32STR
68380	35581 ChEBI	indole		from API rID32A

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68381	15688 ChEBI	acetoin	+		from API rID32STR
68380	35581 ChEBI	indole		-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68380	alanine arylamidase	+	3.4.11.2	from API rID32A
68381	Alanyl-Phenylalanyl-Proline arylamidase	+		from API rID32STR
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68381	alkaline phosphatase	-	3.1.3.1	from API rID32STR
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68381	alpha-galactosidase	-	3.2.1.22	from API rID32STR
68380	alpha-galactosidase	-	3.2.1.22	from API rID32A
68380	alpha-glucosidase	+	3.2.1.20	from API rID32A
68381	arginine dihydrolase	-	3.5.3.6	from API rID32STR
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68381	beta-galactosidase	-	3.2.1.23	from API rID32STR
68380	beta-galactosidase	-	3.2.1.23	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68380	beta-glucosidase	+	3.2.1.21	from API rID32A
68381	beta-glucosidase	-	3.2.1.21	from API rID32STR
68381	beta-glucuronidase	-	3.2.1.31	from API rID32STR
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
68381	beta-mannosidase	-	3.2.1.25	from API rID32STR
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	glycin arylamidase	+		from API rID32A
68381	glycyl tryptophan arylamidase	-		from API rID32STR
68380	histidine arylamidase	+		from API rID32A
68380	L-arginine arylamidase	+		from API rID32A
68380	leucine arylamidase	+	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68381	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32STR
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68380	phenylalanine arylamidase	+		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68381	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32STR
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68380	serine arylamidase	+		from API rID32A
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	+		from API rID32A
68381	urease	-	3.5.1.5	from API rID32STR
68380	urease	-	3.5.1.5	from API rID32A

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
47253	-	-	-	-	-	+	+	-	-	-	+	-	-	-	-	-	-	+	-	-	+	+	-	+	+	+	+	-	+

API rID32STR

@ref	ADH (Arg)	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	TAG	beta MAN	URE
47253	-	-	-	-	-	-	-	+	-	-	+	-	+	-	-	-	+	+	-	-	-	-	-	-	-	+	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host	#Mammals	#Rodentia (Other)
#Host Body-Site	#Oral cavity and airways	#Plaque

Isolation

47253

Sample typeHamster inoculated with human dental plaque

Interaction and safety

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	43908_G01 assembly for Streptococcus sobrinus NCTC10921	complete	GCA_900475365	1310.9	2986664025	1310	98.14

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
124043	Streptococcus sobrinus strain CCUG 21019 16S-23S ribosomal RNA intergenic spacer, partial sequence.	DQ204559	407		1310

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: 43908_G01 assembly for Streptococcus sobrinus NCTC10921
BV-BRC: 1310.9

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	92.56	no
125439	motility	BacteriaNetⓘ	no	76.46	no
125439	gram_stain	BacteriaNetⓘ	negative	49.57	no
125439	spore_formation	BacteriaNetⓘ	no	99.70	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptococcus sobrinus NCTC10921
NCBI: GCA_900475365.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	88.07	no
125438	anaerobic	anaerobicⓘ	no	84.94	no
125438	aerobic	aerobicⓘ	no	98.20	no
125438	spore-forming	spore-formingⓘ	no	90.50	no
125438	thermophilic	thermophileⓘ	no	96.00	no
125438	flagellated	motile2+ⓘ	no	89.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity.	Erttmann SF, Gekara NO.	Nat Commun	10.1038/s41467-019-11169-x	2019
Phylogeny	Array-based identification of species of the genera Abiotrophia, Enterococcus, Granulicatella, and Streptococcus.	Tung SK, Teng LJ, Vaneechoutte M, Chen HM, Chang TC.	J Clin Microbiol	10.1128/jcm.01712-06	2006
	Trans, Trans-Farnesol Enhances the Anti-Bacterial and Anti-Biofilm Effect of Arachidonic Acid on the Cariogenic Bacteria Streptococcus mutans and Streptococcus sobrinus.	Haj-Yahya F, Steinberg D, Sionov RV.	Int J Mol Sci	10.3390/ijms252111770	2024
	Combined potential of copaifera officinalis oleoresin and chitosan against oral pathogens.	Gomes TV, de Oliveira MS, Polo AB, Tome BV, Cardoso MM, Tavares GD, Apolonio ACM.	Braz J Microbiol	10.1007/s42770-024-01523-7	2024
	Synergistic antimicrobial properties of nanoencapsulated clove oil and thymol against oral bacteria.	Lee JS, Choi YS, Lee HG.	Food Sci Biotechnol	10.1007/s10068-020-00803-w	2020
	Anti-Bacterial and Anti-Biofilm Activities of Anandamide against the Cariogenic Streptococcus mutans.	Wolfson G, Sionov RV, Smoum R, Korem M, Polacheck I, Steinberg D.	Int J Mol Sci	10.3390/ijms24076177	2023
	Anti-Bacterial Properties of Cannabigerol Toward Streptococcus mutans.	Aqawi M, Sionov RV, Gallily R, Friedman M, Steinberg D.	Front Microbiol	10.3389/fmicb.2021.656471	2021
Phylogeny	Repetitive extragenic palindromic PCR for study of Streptococcus mutans diversity and transmission in human populations.	Moser SA, Mitchell SC, Ruby JD, Momeni S, Osgood RC, Whiddon J, Childers NK.	J Clin Microbiol	10.1128/jcm.01828-09	2010
	The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics.	Hong H, Sloan L, Saxena D, Scott DA.	Biomedicines	10.3390/biomedicines10081959	2022
	Phylogenetic analyses and detection of viridans streptococci based on sequences and denaturing gradient gel electrophoresis of the rod shape-determining protein gene.	Konishi I, Hoshino T, Kondo Y, Saito K, Nishiguchi M, Sato K, Fujiwara T.	J Oral Microbiol	10.3402/jom.v1i0.2015	2009
Enzymology	Screening of Probiotic Candidates in Human Oral Bacteria for the Prevention of Dental Disease.	Terai T, Okumura T, Imai S, Nakao M, Yamaji K, Ito M, Nagata T, Kaneko K, Miyazaki K, Okada A, Nomura Y, Hanada N.	PLoS One	10.1371/journal.pone.0128657	2015
	Use of insertion sequence element IS1126 in a genotyping and transmission study of Porphyromonas gingivalis.	Park OJ, Min KM, Choe SJ, Choi BK, Kim KK.	J Clin Microbiol	10.1128/jcm.42.2.535-541.2004	2004
Metabolism	Regulation of bacteriocin production and cell death by the VicRK signaling system in Streptococcus mutans.	Senadheera DB, Cordova M, Ayala EA, Chavez de Paz LE, Singh K, Downey JS, Svensater G, Goodman SD, Cvitkovitch DG.	J Bacteriol	10.1128/jb.06071-11	2012
	Intergeneric coaggregation of oral Treponema spp. with Fusobacterium spp. and intrageneric coaggregation among Fusobacterium spp.	Kolenbrander PE, Parrish KD, Andersen RN, Greenberg EP.	Infect Immun	10.1128/iai.63.12.4584-4588.1995	1995
Pathogenicity	Antimicrobial activity of two South African honeys produced from indigenous Leucospermum cordifolium and Erica species on selected micro-organisms.	Basson NJ, Grobler SR.	BMC Complement Altern Med	10.1186/1472-6882-8-41	2008
Phylogeny	Description and evaluation of the semiautomated 4-hour rapid ID 32 Strep method for identification of streptococci and members of related genera.	Freney J, Bland S, Etienne J, Desmonceaux M, Boeufgras JM, Fleurette J.	J Clin Microbiol	10.1128/jcm.30.10.2657-2661.1992	1992
Phylogeny	Identification of clinically relevant nonhemolytic Streptococci on the basis of sequence analysis of 16S-23S intergenic spacer region and partial gdh gene.	Nielsen XC, Justesen US, Dargis R, Kemp M, Christensen JJ.	J Clin Microbiol	10.1128/jcm.01449-08	2009
Enzymology	Characterization of a rat salivary sialoglycoprotein complex which agglutinates Streptococcus mutans.	Brack CM, Reynolds EC	Infect Immun	10.1128/iai.55.5.1264-1273.1987	1987
Genetics	Complete Genome Sequences of Streptococcus sobrinus SL1 (ATCC 33478 = DSM 20742), NIDR 6715-7 (ATCC 27351), NIDR 6715-15 (ATCC 27352), and NCTC 10919 (ATCC 33402).	Sales MJ, Herbert WG, Du Y, Sandur AS, Stanley NM, Jensen PA	Microbiol Resour Announc	10.1128/MRA.00804-18	2018

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#47253	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 21019
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#68380	Automatically annotated from API rID32A .
#68381	Automatically annotated from API rID32STR .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptococcus sobrinus (CCUG 21019, ATCC 27351, NCTC 10921)

Name and taxonomic classification

Morphology

Culture and growth conditions

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

API rID32A

API rID32STR

Isolation, sampling and environmental information

Isolation source categories

Isolation

Interaction and safety

Sequence information

Genome sequences

Genome browser: GCA_900475365

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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