Clostridium botulinum (CCUG 7974, NCTC 8266)

Name: Clostridium botulinum (CCUG 7974, NCTC 8266)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 141869

Type strain

Culture col. no. CCUG 7974 NCTC 8266

NCBI tax ID(s) 1491

Special Collections CCUG

Links

Clostridium botulinum CCUG 7974 is a prokaryote of the family Clostridiaceae.

genome sequence

Name and taxonomic classification

SI-ID 52862

CCUG 7974,NCTC 8266,CECT 4611

@ref 20215

Last LPSN update 2026-02-09 11:34:03

Domain Bacteria

Phylum Bacillota

Class Clostridia

Order Eubacteriales

Family Clostridiaceae

Genus Clostridium

Species Clostridium botulinum

Full scientific name Clostridium botulinum (van Ermengem 1896) Bergey et al. 1923 (Approved Lists 1980)

Synonyms (1)

"Bacillus botulinus"

BacDive ID	Other strains from **Clostridium botulinum** (14)	Type strain
166627	C. botulinum CIP 104310, ATCC 25763 (type strain)
141845	C. botulinum CCUG 7735
141865	C. botulinum CCUG 7968, ATCC 19397, NCTC 7272
141866	C. botulinum CCUG 7969, NCTC 7273
141867	C. botulinum CCUG 7970, NCTC 8264
141868	C. botulinum CCUG 7971, NCTC 8265
142345	C. botulinum CCUG 11910
142708	C. botulinum CCUG 14228
144075	C. botulinum CCUG 22775
146789	C. botulinum CCUG 32121
146790	C. botulinum CCUG 32122
146791	C. botulinum CCUG 32123
149343	C. botulinum CCUG 37546
150472	C. botulinum CCUG 41389

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	positive	91.2

Culture and growth conditions

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	anaerobe	99.4

Isolation, sampling and environmental information

Isolation

@ref	Country	Country ISO 3 Code	Continent
45055	Canada	CAN	North America

Interaction and safety

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM82793v1 assembly for Clostridium botulinum NCTC 8266	complete	GCA_000827935	1491.354	2651869840	1491	99.25
124043	ASM1101509v1 assembly for Clostridium botulinum NCTC 8266	contig	GCA_011015095			1491	47.2

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Clostridium botulinum NCTC 8266
NCBI: GCA_000827935

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	82.30	no
125439	motility	BacteriaNetⓘ	yes	80.40	no
125439	gram_stain	BacteriaNetⓘ	positive	91.20	no
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	99.40	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Clostridium botulinum NCTC 8266
NCBI: GCA_000827935.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	55.91	no
125438	anaerobic	anaerobicⓘ	yes	89.32	no
125438	aerobic	aerobicⓘ	no	98.76	no
125438	spore-forming	spore-formingⓘ	yes	72.89	no
125438	thermophilic	thermophileⓘ	no	90.39	no
125438	flagellated	motile2+ⓘ	yes	78.83	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	Tracing and characterization of foodborne botulism caused by the new MLST type Clostridium botulinum A2 in Hebei province, China.	Lu Z, Feng J, Luo X, Sun H, Huang Y, Lu S, Wang D, Xu X, Lu X, Xu L.	Front Microbiol	10.3389/fmicb.2025.1567360	2025
	The Impact of Allicin on the Growth of Clostridium spp. in the Digestive Track of Quails.	Makuch A, Ziomek M, Sapala M, Drabik K, Batkowska J, Domaradzki P, Patyra E, Grenda T.	Animals (Basel)	10.3390/ani15070906	2025
	Potential Risk of Botulinum Neurotoxin -producing Clostridia Occurrence in Canned Fish.	Jarosz A, Grenda T, Goldsztejn M, Kozak B, Kwiatek K.	J Vet Res	10.2478/jvetres-2022-0060	2022
Phylogeny	Novel Putative Transposable Element Associated with the Subtype E5 Botulinum Toxin Gene Cluster of Neurotoxigenic Clostridium butyricum Type E Strains from China.	Li T, Ning N, Iacobino A, Zhang L, Wang H, Franciosa G.	Int J Mol Sci	10.3390/ijms23020906	2022
Enzymology	Clostridium botulinum and Clostridium perfringens Occurrence in Kazakh Honey Samples.	Maikanov B, Mustafina R, Auteleyeva L, Wisniewski J, Anusz K, Grenda T, Kwiatek K, Goldsztejn M, Grabczak M.	Toxins (Basel)	10.3390/toxins11080472	2019
Biotechnology	Clostridium botulinum spores in Polish honey samples.	Grenda T, Grabczak M, Sieradzki Z, Kwiatek K, Pohorecka K, Skubida M, Bober A.	J Vet Sci	10.4142/jvs.2018.19.5.635	2018
Genetics	Complete Genome Sequence of Clostridium estertheticum DSM 8809, a Microbe Identified in Spoiled Vacuum Packed Beef.	Yu Z, Gunn L, Brennan E, Reid R, Wall PG, Gaora PO, Hurley D, Bolton D, Fanning S.	Front Microbiol	10.3389/fmicb.2016.01764	2016
	Prevalence of C. Botulinum and C. Perfringens Spores in Food Products Available on Polish Market.	Grenda T, Grabczak M, Kwiatek K, Bober A.	J Vet Res	10.1515/jvetres-2017-0038	2017
Phylogeny	Evolution of Chromosomal Clostridium botulinum Type E Neurotoxin Gene Clusters: Evidence Provided by Their Rare Plasmid-Borne Counterparts.	Carter AT, Austin JW, Weedmark KA, Peck MW.	Genome Biol Evol	10.1093/gbe/evw017	2016
	Gut Microbiome of an 11th Century A.D. Pre-Columbian Andean Mummy.	Santiago-Rodriguez TM, Fornaciari G, Luciani S, Dowd SE, Toranzos GA, Marota I, Cano RJ.	PLoS One	10.1371/journal.pone.0138135	2015
Phylogeny	Clostridium botulinum Group II Isolate Phylogenomic Profiling Using Whole-Genome Sequence Data.	Weedmark KA, Mabon P, Hayden KL, Lambert D, Van Domselaar G, Austin JW, Corbett CR.	Appl Environ Microbiol	10.1128/aem.01155-15	2015
	Pentaplexed quantitative real-time PCR assay for the simultaneous detection and quantification of botulinum neurotoxin-producing clostridia in food and clinical samples.	Kirchner S, Kramer KM, Schulze M, Pauly D, Jacob D, Gessler F, Nitsche A, Dorner BG, Dorner MB.	Appl Environ Microbiol	10.1128/aem.02490-09	2010
Enzymology	Detection by PCR-enzyme-linked immunosorbent assay of Clostridium botulinum in fish and environmental samples from a coastal area in northern France.	Fach P, Perelle S, Dilasser F, Grout J, Dargaignaratz C, Botella L, Gourreau JM, Carlin F, Popoff MR, Broussolle V.	Appl Environ Microbiol	10.1128/aem.68.12.5870-5876.2002	2002
Enzymology	Sensitive detection of botulinum neurotoxin types C and D with an immunoaffinity chromatographic column test.	Gessler F, Hampe K, Bohnel H.	Appl Environ Microbiol	10.1128/aem.71.12.7897-7903.2005	2005
	Improvement in laboratory diagnosis of wound botulism and tetanus among injecting illicit-drug users by use of real-time PCR assays for neurotoxin gene fragments.	Akbulut D, Grant KA, McLauchlin J.	J Clin Microbiol	10.1128/jcm.43.9.4342-4348.2005	2005
Metabolism	The production of Clostridium botulinum toxin in mammalian, avian and piscine carrion.	Smith GR, Turner A.	Epidemiol Infect	10.1017/s0950268800030181	1989
Enzymology	Ruminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces.	Dabard J, Bridonneau C, Phillipe C, Anglade P, Molle D, Nardi M, Ladire M, Girardin H, Marcille F, Gomez A, Fons M.	Appl Environ Microbiol	10.1128/aem.67.9.4111-4118.2001	2001
Genetics	Two Complete and One Draft Genome Sequence of Nonproteolytic Clostridium botulinum Type E Strains NCTC 8266, NCTC 8550, and NCTC 11219.	Clauwers C, Briers Y, Lavigne R, Michiels CW	Genome Announc	10.1128/genomeA.00083-15	2015

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#45055	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 7974
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Clostridium botulinum (CCUG 7974, NCTC 8266)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Physiology and metabolism

Oxygen tolerance

Isolation, sampling and environmental information

Isolation

Interaction and safety

Sequence information

Genome sequences

Genome browser: GCA_000827935

Genome-based predictions

Predictions

Literature

Literature

References

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