Clostridium botulinum CCUG 7969 is a prokaryote of the family Clostridiaceae.
genome sequence 16S sequence| @ref 20215 |
Last LPSN update
2026-02-09 11:34:03 |
| Domain Bacteria |
| Phylum Bacillota |
| Class Clostridia |
| Order Eubacteriales |
| Family Clostridiaceae |
| Genus Clostridium |
| Species Clostridium botulinum |
| Full scientific name Clostridium botulinum (van Ermengem 1896) Bergey et al. 1923 (Approved Lists 1980) |
| Synonyms (1) |
| @ref | Oxygen tolerance | Confidence | |
|---|---|---|---|
| 125439 | anaerobe | 98 |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68380 | 29016 ChEBI | arginine | + | hydrolysis | from API rID32A |
| 68380 | 16024 ChEBI | D-mannose | - | fermentation | from API rID32A |
| 68380 | 29985 ChEBI | L-glutamate | - | degradation | from API rID32A |
| 68380 | 17632 ChEBI | nitrate | - | reduction | from API rID32A |
| 68380 | 16634 ChEBI | raffinose | - | fermentation | from API rID32A |
| 68380 | 27897 ChEBI | tryptophan | - | energy source | from API rID32A |
| 68380 | 16199 ChEBI | urea | - | hydrolysis | from API rID32A |
| @ref | Chebi-ID | Metabolite | Production | |
|---|---|---|---|---|
| 68380 | 35581 ChEBI | indole | from API rID32A |
| @ref | Chebi-ID | Metabolite | Indole test | |
|---|---|---|---|---|
| 68380 | 35581 ChEBI | indole | - | from API rID32A |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | - | 3.1.3.2 | from API zym |
| 68380 | alanine arylamidase | - | 3.4.11.2 | from API rID32A |
| 68382 | alkaline phosphatase | - | 3.1.3.1 | from API zym |
| 68380 | alkaline phosphatase | - | 3.1.3.1 | from API rID32A |
| 68380 | alpha-arabinosidase | - | 3.2.1.55 | from API rID32A |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68380 | alpha-fucosidase | - | 3.2.1.51 | from API rID32A |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68380 | alpha-galactosidase | - | 3.2.1.22 | from API rID32A |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68380 | alpha-glucosidase | - | 3.2.1.20 | from API rID32A |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68380 | arginine dihydrolase | + | 3.5.3.6 | from API rID32A |
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 68380 | beta-galactosidase | - | 3.2.1.23 | from API rID32A |
| 68380 | beta-Galactosidase 6-phosphate | - | from API rID32A | |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68380 | beta-glucosidase | + | 3.2.1.21 | from API rID32A |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 68380 | beta-glucuronidase | - | 3.2.1.31 | from API rID32A |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | - | from API zym | |
| 68380 | glutamate decarboxylase | - | 4.1.1.15 | from API rID32A |
| 68380 | glutamyl-glutamate arylamidase | - | from API rID32A | |
| 68380 | glycin arylamidase | - | from API rID32A | |
| 68380 | histidine arylamidase | - | from API rID32A | |
| 68380 | L-arginine arylamidase | - | from API rID32A | |
| 68382 | leucine arylamidase | - | 3.4.11.1 | from API zym |
| 68380 | leucine arylamidase | - | 3.4.11.1 | from API rID32A |
| 68380 | leucyl glycin arylamidase | - | 3.4.11.1 | from API rID32A |
| 68382 | lipase (C 14) | - | from API zym | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68380 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API rID32A |
| 68382 | naphthol-AS-BI-phosphohydrolase | - | from API zym | |
| 68380 | phenylalanine arylamidase | - | from API rID32A | |
| 68380 | proline-arylamidase | - | 3.4.11.5 | from API rID32A |
| 68380 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API rID32A |
| 68380 | serine arylamidase | - | from API rID32A | |
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68380 | tryptophan deaminase | - | 4.1.99.1 | from API rID32A |
| 68380 | tyrosine arylamidase | - | from API rID32A | |
| 68380 | urease | - | 3.5.1.5 | from API rID32A |
| 68382 | valine arylamidase | - | from API zym |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|
| 124043 | ASM1101395v1 assembly for Clostridium botulinum NCTC 7273 (2) | contig | GCA_011013955   | 1491 | 27.2 | | |
| 66792 | ASM1759111v1 assembly for Clostridium botulinum CCUG 7969 | contig | GCA_017591115 | 1491.1882  | 1491 | 20.92 | |
| 124043 | ASM1101723v1 assembly for Clostridium botulinum NCTC 7273 | contig | GCA_011017235 | 1491 | 20.6 | |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 124043 | Clostridium botulinum type B rrn gene for 16S RNA | X68186 | 1510 | | 1491 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Detection of Active BoNT/C and D by EndoPep-MS Using MALDI Biotyper Instrument and Comparison with the Mouse Test Bioassay. | Drigo I, Tonon E, Pascoletti S, Anniballi F, Kalb SR, Bano L. | Toxins (Basel) | 10.3390/toxins13010010 | 2020 | | |
| Pentaplexed quantitative real-time PCR assay for the simultaneous detection and quantification of botulinum neurotoxin-producing clostridia in food and clinical samples. | Kirchner S, Kramer KM, Schulze M, Pauly D, Jacob D, Gessler F, Nitsche A, Dorner BG, Dorner MB. | Appl Environ Microbiol | 10.1128/aem.02490-09 | 2010 | | |
| Physical Treatments to Control Clostridium botulinum Hazards in Food. | Munir MT, Mtimet N, Guillier L, Meurens F, Fravalo P, Federighi M, Kooh P. | Foods | 10.3390/foods12081580 | 2023 | | |
| Integration of Complete Plasmids Containing Bont Genes into Chromosomes of Clostridium parabotulinum, Clostridium sporogenes, and Clostridium argentinense. | Smith TJ, Tian R, Imanian B, Williamson CHD, Johnson SL, Daligault HE, Schill KM. | Toxins (Basel) | 10.3390/toxins13070473 | 2021 | | |
| Phylogeny | Diversity of Group I and II Clostridium botulinum Strains from France Including Recently Identified Subtypes. | Mazuet C, Legeay C, Sautereau J, Ma L, Bouchier C, Bouvet P, Popoff MR. | Genome Biol Evol | 10.1093/gbe/evw101 | 2016 | |
| Phylogeny | Clear distinction between Burkholderia mallei and Burkholderia pseudomallei using fluorescent motB primers. | Schmoock G, Elschner M, Sprague LD. | Acta Vet Scand | 10.1186/s13028-015-0104-4 | 2015 | |
| Biotechnology | Erythrophore cell response to food-associated pathogenic bacteria: implications for detection. | Hutchison JR, Dukovcic SR, Dierksen KP, Carlyle CA, Caldwell BA, Trempy JE. | Microb Biotechnol | 10.1111/j.1751-7915.2008.00045.x | 2008 | |
| Metabolism | Potential of the melanophore pigment response for detection of bacterial toxicity. | Dukovcic SR, Hutchison JR, Trempy JE. | Appl Environ Microbiol | 10.1128/aem.01241-10 | 2010 | |
| Coherent pipeline for biomarker discovery using mass spectrometry and bioinformatics. | Al-Shahib A, Misra R, Ahmod N, Fang M, Shah H, Gharbia S. | BMC Bioinformatics | 10.1186/1471-2105-11-437 | 2010 | | |
| Metabolism | Effects of carbon dioxide on growth of proteolytic Clostridium botulinum, its ability to produce neurotoxin, and its transcriptome. | Artin I, Mason DR, Pin C, Schelin J, Peck MW, Holst E, Radstrom P, Carter AT. | Appl Environ Microbiol | 10.1128/aem.02247-09 | 2010 | |
| Characterization of botulinum progenitor toxins by mass spectrometry. | Hines HB, Lebeda F, Hale M, Brueggemann EE. | Appl Environ Microbiol | 10.1128/aem.71.8.4478-4486.2005 | 2005 | | |
| Enzymology | Rapid affinity immunochromatography column-based tests for sensitive detection of Clostridium botulinum neurotoxins and Escherichia coli O157. | Brunt J, Webb MD, Peck MW. | Appl Environ Microbiol | 10.1128/aem.03059-09 | 2010 | |
| Phylogeny | Differentiation of Clostridium botulinum serotype A strains by multiple-locus variable-number tandem-repeat analysis. | Macdonald TE, Helma CH, Ticknor LO, Jackson PJ, Okinaka RT, Smith LA, Smith TJ, Hill KK. | Appl Environ Microbiol | 10.1128/aem.01539-07 | 2008 | |
| Gene probes for identification of the botulinal neurotoxin gene and specific identification of neurotoxin types B, E, and F. | Campbell KD, Collins MD, East AK. | J Clin Microbiol | 10.1128/jcm.31.9.2255-2262.1993 | 1993 | | |
| Enzymology | Specific detection of Clostridium botulinum type B by using the polymerase chain reaction. | Szabo EA, Pemberton JM, Desmarchelier PM. | Appl Environ Microbiol | 10.1128/aem.58.1.418-420.1992 | 1992 | |
| Enzymology | Sensitive detection of botulinum neurotoxin types C and D with an immunoaffinity chromatographic column test. | Gessler F, Hampe K, Bohnel H. | Appl Environ Microbiol | 10.1128/aem.71.12.7897-7903.2005 | 2005 | |
| Genetics | Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes. | Sebaihia M, Peck MW, Minton NP, Thomson NR, Holden MT, Mitchell WJ, Carter AT, Bentley SD, Mason DR, Crossman L, Paul CJ, Ivens A, Wells-Bennik MH, Davis IJ, Cerdeno-Tarraga AM, Churcher C, Quail MA, Chillingworth T, Feltwell T, Fraser A, Goodhead I, Hance Z, Jagels K, Larke N, Maddison M, Moule S, Mungall K, Norbertczak H, Rabbinowitsch E, Sanders M, Simmonds M, White B, Whithead S, Parkhill J. | Genome Res | 10.1101/gr.6282807 | 2007 | |
| Detection of the genes encoding botulinum neurotoxin types A to E by the polymerase chain reaction. | Szabo EA, Pemberton JM, Desmarchelier PM. | Appl Environ Microbiol | 10.1128/aem.59.9.3011-3020.1993 | 1993 | | |
| Application of PCR to a clinical and environmental investigation of a case of equine botulism. | Szabo EA, Pemberton JM, Gibson AM, Thomas RJ, Pascoe RR, Desmarchelier PM. | J Clin Microbiol | 10.1128/jcm.32.8.1986-1991.1994 | 1994 | | |
| Biotechnology | Development of an in vitro bioassay for Clostridium botulinum type B neurotoxin in foods that is more sensitive than the mouse bioassay. | Wictome M, Newton K, Jameson K, Hallis B, Dunnigan P, Mackay E, Clarke S, Taylor R, Gaze J, Foster K, Shone C. | Appl Environ Microbiol | 10.1128/aem.65.9.3787-3792.1999 | 1999 | |
| Genetic diversity among Botulinum Neurotoxin-producing clostridial strains. | Hill KK, Smith TJ, Helma CH, Ticknor LO, Foley BT, Svensson RT, Brown JL, Johnson EA, Smith LA, Okinaka RT, Jackson PJ, Marks JD. | J Bacteriol | 10.1128/jb.01180-06 | 2007 | | |
| Metabolism | The production of Clostridium botulinum type A, B and D toxin in rotting carcasses. | Ortiz NE, Smith GR. | Epidemiol Infect | 10.1017/s0950268800051761 | 1994 | |
| Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum. | Carter AT, Paul CJ, Mason DR, Twine SM, Alston MJ, Logan SM, Austin JW, Peck MW. | BMC Genomics | 10.1186/1471-2164-10-115 | 2009 | | |
| Enzymology | Microbial identification by mass cataloging. | Zhang Z, Jackson GW, Fox GE, Willson RC. | BMC Bioinformatics | 10.1186/1471-2105-7-117 | 2006 | |
| Enzymology | Ruminococcin A, a new lantibiotic produced by a Ruminococcus gnavus strain isolated from human feces. | Dabard J, Bridonneau C, Phillipe C, Anglade P, Molle D, Nardi M, Ladire M, Girardin H, Marcille F, Gomez A, Fons M. | Appl Environ Microbiol | 10.1128/aem.67.9.4111-4118.2001 | 2001 | |
| Development of novel assays for botulinum type A and B neurotoxins based on their endopeptidase activities. | Hallis B, James BA, Shone CC. | J Clin Microbiol | 10.1128/jcm.34.8.1934-1938.1996 | 1996 | | |
| Biotechnology | Synergistic inactivation of spores of proteolytic Clostridium botulinum strains by high pressure and heat is strain and product dependent. | Bull MK, Olivier SA, van Diepenbeek RJ, Kormelink F, Chapman B | Appl Environ Microbiol | 10.1128/AEM.01426-08 | 2008 | |
| Phylogeny | Isolation and characterization of proteolytic ruminal bacteria from sheep and goats fed the tannin-containing shrub legume Calliandra calothyrsus. | McSweeney CS, Palmer B, Bunch R, Krause DO | Appl Environ Microbiol | 10.1128/AEM.65.7.3075-3083.1999 | 1999 | |
| Phylogeny | Organization and phylogenetic interrelationships of genes encoding components of the botulinum toxin complex in proteolytic Clostridium botulinum types A, B, and F: evidence of chimeric sequences in the gene encoding the nontoxic nonhemagglutinin component. | East AK, Bhandari M, Stacey JM, Campbell KD, Collins MD | Int J Syst Bacteriol | 10.1099/00207713-46-4-1105 | 1996 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive141866.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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