Shigella flexneri 2457T is a facultative anaerobe, mesophilic, Gram-negative prokaryote that was isolated from Human, Feces.
Gram-negative rod-shaped facultative anaerobe mesophilic| @ref 20215 |
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| Domain Pseudomonadati |
| Phylum Pseudomonadota |
| Class Gammaproteobacteria |
| Order Enterobacterales |
| Family Enterobacteriaceae |
| Genus Shigella |
| Species Shigella flexneri |
| Full scientific name Shigella flexneri Castellani and Chalmers 1919 (Approved Lists 1980) |
| @ref | Gram stain | Cell shape | Motility | |
|---|---|---|---|---|
| 41696 | negative | rod-shaped |
| @ref | Name | Growth | Composition | Medium link | |
|---|---|---|---|---|---|
| 41696 | MEDIUM 72- for trypto casein soja agar | Distilled water make up to (1000.000 ml);Trypto casein soy agar (40.000 g) | |||
| 41696 | CIP Medium 72 | Medium recipe at CIP |
| 41696 | Oxygen tolerancefacultative anaerobe |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 41696 | 16947 ChEBI | citrate | - | carbon source | |
| 41696 | 17234 ChEBI | glucose | + | fermentation | |
| 41696 | 17716 ChEBI | lactose | - | fermentation | |
| 41696 | 15792 ChEBI | malonate | - | assimilation | |
| 41696 | 29864 ChEBI | mannitol | + | fermentation | |
| 41696 | 17632 ChEBI | nitrate | + | reduction | |
| 41696 | 16301 ChEBI | nitrite | - | reduction | |
| 41696 | 132112 ChEBI | sodium thiosulfate | - | builds gas from |
| @ref | Metabolite | Is sensitive | Is resistant | |
|---|---|---|---|---|
| 41696 | 0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate) |
| @ref | pathway | enzyme coverage | annotated reactions | external links | |
|---|---|---|---|---|---|
| 66794 | L-lactaldehyde degradation | 100 | 3 of 3 | ||
| 66794 | coenzyme A metabolism | 100 | 4 of 4 | ||
| 66794 | anapleurotic synthesis of oxalacetate | 100 | 1 of 1 | ||
| 66794 | aerobactin biosynthesis | 100 | 1 of 1 | ||
| 66794 | 4-hydroxyphenylacetate degradation | 100 | 10 of 10 | ||
| 66794 | ppGpp biosynthesis | 100 | 4 of 4 | ||
| 66794 | methylglyoxal degradation | 100 | 5 of 5 | ||
| 66794 | taurine degradation | 100 | 1 of 1 | ||
| 66794 | adipate degradation | 100 | 2 of 2 | ||
| 66794 | suberin monomers biosynthesis | 100 | 2 of 2 | ||
| 66794 | CDP-diacylglycerol biosynthesis | 100 | 2 of 2 | ||
| 66794 | UDP-GlcNAc biosynthesis | 100 | 3 of 3 | ||
| 66794 | starch degradation | 100 | 10 of 10 | ||
| 66794 | biotin biosynthesis | 100 | 4 of 4 | ||
| 66794 | sulfopterin metabolism | 100 | 4 of 4 | ||
| 66794 | formaldehyde oxidation | 100 | 3 of 3 | ||
| 66794 | acetate fermentation | 100 | 4 of 4 | ||
| 66794 | enterobactin biosynthesis | 100 | 3 of 3 | ||
| 66794 | tetrahydrofolate metabolism | 100 | 14 of 14 | ||
| 66794 | folate polyglutamylation | 100 | 1 of 1 | ||
| 66794 | ubiquinone biosynthesis | 100 | 7 of 7 | ||
| 66794 | sulfoquinovose degradation | 100 | 3 of 3 | ||
| 66794 | gluconeogenesis | 100 | 8 of 8 | ||
| 66794 | vitamin K metabolism | 100 | 5 of 5 | ||
| 66794 | palmitate biosynthesis | 95.45 | 21 of 22 | ||
| 66794 | NAD metabolism | 94.44 | 17 of 18 | ||
| 66794 | heme metabolism | 92.86 | 13 of 14 | ||
| 66794 | glutathione metabolism | 92.86 | 13 of 14 | ||
| 66794 | photosynthesis | 92.86 | 13 of 14 | ||
| 66794 | vitamin B6 metabolism | 90.91 | 10 of 11 | ||
| 66794 | pentose phosphate pathway | 90.91 | 10 of 11 | ||
| 66794 | Entner Doudoroff pathway | 90 | 9 of 10 | ||
| 66794 | threonine metabolism | 90 | 9 of 10 | ||
| 66794 | valine metabolism | 88.89 | 8 of 9 | ||
| 66794 | serine metabolism | 88.89 | 8 of 9 | ||
| 66794 | lipid A biosynthesis | 88.89 | 8 of 9 | ||
| 66794 | chorismate metabolism | 88.89 | 8 of 9 | ||
| 66794 | molybdenum cofactor biosynthesis | 88.89 | 8 of 9 | ||
| 66794 | C4 and CAM-carbon fixation | 87.5 | 7 of 8 | ||
| 66794 | degradation of sugar alcohols | 87.5 | 14 of 16 | ||
| 66794 | isoleucine metabolism | 87.5 | 7 of 8 | ||
| 66794 | reductive acetyl coenzyme A pathway | 85.71 | 6 of 7 | ||
| 66794 | vitamin B1 metabolism | 84.62 | 11 of 13 | ||
| 66794 | glycolate and glyoxylate degradation | 83.33 | 5 of 6 | ||
| 66794 | purine metabolism | 82.98 | 78 of 94 | ||
| 66794 | gallate degradation | 80 | 4 of 5 | ||
| 66794 | peptidoglycan biosynthesis | 80 | 12 of 15 | ||
| 66794 | glycogen metabolism | 80 | 4 of 5 | ||
| 66794 | metabolism of amino sugars and derivatives | 80 | 4 of 5 | ||
| 66794 | pyrimidine metabolism | 80 | 36 of 45 | ||
| 66794 | alanine metabolism | 79.31 | 23 of 29 | ||
| 66794 | glutamate and glutamine metabolism | 78.57 | 22 of 28 | ||
| 66794 | citric acid cycle | 78.57 | 11 of 14 | ||
| 66794 | aspartate and asparagine metabolism | 77.78 | 7 of 9 | ||
| 66794 | d-mannose degradation | 77.78 | 7 of 9 | ||
| 66794 | phenylalanine metabolism | 76.92 | 10 of 13 | ||
| 66794 | urea cycle | 76.92 | 10 of 13 | ||
| 66794 | glycogen biosynthesis | 75 | 3 of 4 | ||
| 66794 | lactate fermentation | 75 | 3 of 4 | ||
| 66794 | dTDPLrhamnose biosynthesis | 75 | 6 of 8 | ||
| 66794 | CMP-KDO biosynthesis | 75 | 3 of 4 | ||
| 66794 | 6-hydroxymethyl-dihydropterin diphosphate biosynthesis | 75 | 6 of 8 | ||
| 66794 | flavin biosynthesis | 73.33 | 11 of 15 | ||
| 66794 | oxidative phosphorylation | 72.53 | 66 of 91 | ||
| 66794 | degradation of sugar acids | 72 | 18 of 25 | ||
| 66794 | cardiolipin biosynthesis | 71.43 | 5 of 7 | ||
| 66794 | lipid metabolism | 70.97 | 22 of 31 | ||
| 66794 | glycolysis | 70.59 | 12 of 17 | ||
| 66794 | leucine metabolism | 69.23 | 9 of 13 | ||
| 66794 | non-pathway related | 68.42 | 26 of 38 | ||
| 66794 | degradation of pentoses | 67.86 | 19 of 28 | ||
| 66794 | allantoin degradation | 66.67 | 6 of 9 | ||
| 66794 | CO2 fixation in Crenarchaeota | 66.67 | 6 of 9 | ||
| 66794 | cyanate degradation | 66.67 | 2 of 3 | ||
| 66794 | octane oxidation | 66.67 | 2 of 3 | ||
| 66794 | selenocysteine biosynthesis | 66.67 | 4 of 6 | ||
| 66794 | methane metabolism | 66.67 | 2 of 3 | ||
| 66794 | acetoin degradation | 66.67 | 2 of 3 | ||
| 66794 | tryptophan metabolism | 65.79 | 25 of 38 | ||
| 66794 | isoprenoid biosynthesis | 65.38 | 17 of 26 | ||
| 66794 | proline metabolism | 63.64 | 7 of 11 | ||
| 66794 | ketogluconate metabolism | 62.5 | 5 of 8 | ||
| 66794 | methionine metabolism | 61.54 | 16 of 26 | ||
| 66794 | degradation of hexoses | 61.11 | 11 of 18 | ||
| 66794 | hydrogen production | 60 | 3 of 5 | ||
| 66794 | lipoate biosynthesis | 60 | 3 of 5 | ||
| 66794 | propanol degradation | 57.14 | 4 of 7 | ||
| 66794 | cysteine metabolism | 55.56 | 10 of 18 | ||
| 66794 | nitrate assimilation | 55.56 | 5 of 9 | ||
| 66794 | phenol degradation | 55 | 11 of 20 | ||
| 66794 | arginine metabolism | 54.17 | 13 of 24 | ||
| 66794 | sulfate reduction | 53.85 | 7 of 13 | ||
| 66794 | 3-phenylpropionate degradation | 53.33 | 8 of 15 | ||
| 66794 | lysine metabolism | 52.38 | 22 of 42 | ||
| 66794 | histidine metabolism | 51.72 | 15 of 29 | ||
| 66794 | carnitine metabolism | 50 | 4 of 8 | ||
| 66794 | myo-inositol biosynthesis | 50 | 5 of 10 | ||
| 66794 | toluene degradation | 50 | 2 of 4 | ||
| 66794 | pantothenate biosynthesis | 50 | 3 of 6 | ||
| 66794 | ribulose monophosphate pathway | 50 | 1 of 2 | ||
| 66794 | propionate fermentation | 50 | 5 of 10 | ||
| 66794 | quinate degradation | 50 | 1 of 2 | ||
| 66794 | butanoate fermentation | 50 | 2 of 4 | ||
| 66794 | ethanol fermentation | 50 | 1 of 2 | ||
| 66794 | cis-vaccenate biosynthesis | 50 | 1 of 2 | ||
| 66794 | tyrosine metabolism | 50 | 7 of 14 | ||
| 66794 | polyamine pathway | 47.83 | 11 of 23 | ||
| 66794 | ascorbate metabolism | 45.45 | 10 of 22 | ||
| 66794 | d-xylose degradation | 45.45 | 5 of 11 | ||
| 66794 | metabolism of disaccharids | 45.45 | 5 of 11 | ||
| 66794 | degradation of aromatic, nitrogen containing compounds | 41.67 | 5 of 12 | ||
| 66794 | ethylmalonyl-CoA pathway | 40 | 2 of 5 | ||
| 66794 | coenzyme M biosynthesis | 40 | 4 of 10 | ||
| 66794 | glycine metabolism | 40 | 4 of 10 | ||
| 66794 | 3-chlorocatechol degradation | 40 | 2 of 5 | ||
| 66794 | phosphatidylethanolamine bioynthesis | 38.46 | 5 of 13 | ||
| 66794 | phenylpropanoid biosynthesis | 38.46 | 5 of 13 | ||
| 66794 | acetyl CoA biosynthesis | 33.33 | 1 of 3 | ||
| 66794 | IAA biosynthesis | 33.33 | 1 of 3 | ||
| 66794 | methanogenesis from CO2 | 33.33 | 4 of 12 | ||
| 66794 | sphingosine metabolism | 33.33 | 2 of 6 | ||
| 66794 | vitamin B12 metabolism | 32.35 | 11 of 34 | ||
| 66794 | androgen and estrogen metabolism | 31.25 | 5 of 16 | ||
| 66794 | arachidonic acid metabolism | 27.78 | 5 of 18 | ||
| 66794 | cyclohexanol degradation | 25 | 1 of 4 |
| 41696 | Sample typeHuman, Feces |
| @ref | Biosafety level | Biosafety level comment | |
|---|---|---|---|
| 41696 | 2 | Risk group (French classification) |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Proteome | Estimating relative biomasses of organisms in microbiota using "phylopeptidomics". | Pible O, Allain F, Jouffret V, Culotta K, Miotello G, Armengaud J. | Microbiome | 10.1186/s40168-020-00797-x | 2020 | |
| Transcriptome | Multidimensional third-generation sequencing of modified DNA bases allows interrogation of complex biological systems. | David SS, Pacheco BA, Kishimoto K, Vantine S, Hu K, Liu H, Davis DL, Tran H, Sallis BF, Ali L, Haynes CM, McCormick BA, Zhu LJ, Flavahan WA. | Nat Commun | 10.1038/s41467-025-60896-x | 2025 | |
| Novel inhibitors that target bacterial virulence identified via HTS against intra-macrophage survival of Shigella flexneri. | Miljkovic M, Lozano S, Castellote I, de Cozar C, Villegas-Moreno AI, Gamallo P, Jimenez-Alfaro Martinez D, Fernandez-Alvaro E, Ballell L, Garcia GA. | mSphere | 10.1128/msphere.00154-23 | 2023 | ||
| Phylogeny | Phylogenomics, evolution and origin of multidrug-resistant Acinetobacter baumannii ST15. | Abu Sabah E, Tobin LA, Lebreton F, McGann PT, Hamidian M. | Microb Genom | 10.1099/mgen.0.001450 | 2025 | |
| Metabolism | Formate Metabolism in Shigella flexneri and Its Effect on HeLa Cells at Different Stages during the Infectious Process. | Wang KC, Lerche MH, Ardenkjaer-Larsen JH, Jensen PR. | Microbiol Spectr | 10.1128/spectrum.00631-22 | 2023 | |
| Enzymology | Monoclonal Antibodies to Shigella Lipopolysaccharide Are Useful for Vaccine Production. | Lin J, Smith MA, Benjamin WH, Kaminski RW, Wenzel H, Nahm MH. | Clin Vaccine Immunol | 10.1128/cvi.00148-16 | 2016 | |
| The integrase of genomic island GIsul2 mediates the mobilization of GIsul2 and ISCR-related element CR2-sul2 unit through site-specific recombination. | Zhang G, Cui Q, Li J, Guo R, Leclercq SO, Du L, Tang N, Song Y, Wang C, Zhao F, Feng J. | Front Microbiol | 10.3389/fmicb.2022.905865 | 2022 | ||
| Chrysanthemum indicum and Chrysanthemum morifolium: Chemical Composition of Their Essential Oils and Their Potential Use as Natural Preservatives with Antimicrobial and Antioxidant Activities. | Youssef FS, Eid SY, Alshammari E, Ashour ML, Wink M, El-Readi MZ, El-Readi MZ. | Foods | 10.3390/foods9101460 | 2020 | ||
| Efficient production of immunologically active Shigella invasion plasmid antigens IpaB and IpaH using a cell-free expression system. | Kapoor N, Ndungo E, Pill L, Desalegn G, Berges A, Oaks EV, Fairman J, Pasetti MF. | Appl Microbiol Biotechnol | 10.1007/s00253-021-11701-4 | 2022 | ||
| The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp. | Fernandez Alvaro E, Voong Vinh P, de Cozar C, Wille DR, Urones B, Cortes A, Price A, Tran Do Hoang N, Ha Thanh T, McCloskey M, Shaheen S, Dayao D, Martinot A, de Mercado J, Castaneda P, Garcia-Perez A, Singa B, Pavlinac P, Walson J, Martinez-Martinez MS, Arnold SLM, Tzipori S, Ballell Pages L, Baker S. | Elife | 10.7554/elife.69798 | 2022 | ||
| Metabolism | Roles of H2 uptake hydrogenases in Shigella flexneri acid tolerance. | McNorton MM, Maier RJ. | Microbiology (Reading) | 10.1099/mic.0.058248-0 | 2012 | |
| Phylogeny | Multilocus variable-number tandem repeat analysis for molecular typing and phylogenetic analysis of Shigella flexneri. | Wang YW, Watanabe H, Phung DC, Tung SK, Lee YS, Terajima J, Liang SY, Chiou CS. | BMC Microbiol | 10.1186/1471-2180-9-278 | 2009 | |
| Metabolism | Construction of p16Slux, a novel vector for improved bioluminescent labeling of gram-negative bacteria. | Riedel CU, Casey PG, Mulcahy H, O'Gara F, Gahan CG, Hill C. | Appl Environ Microbiol | 10.1128/aem.01394-07 | 2007 | |
| Phylogeny | Selection and validation of a multilocus variable-number tandem-repeat analysis panel for typing Shigella spp. | Gorge O, Lopez S, Hilaire V, Lisanti O, Ramisse V, Vergnaud G. | J Clin Microbiol | 10.1128/jcm.02027-07 | 2008 | |
| Pathogenicity | Alternative hand contamination technique to compare the activities of antimicrobial and nonantimicrobial soaps under different test conditions. | Fuls JL, Rodgers ND, Fischler GE, Howard JM, Patel M, Weidner PL, Duran MH. | Appl Environ Microbiol | 10.1128/aem.02405-07 | 2008 | |
| Phylogeny | Multiplex PCR for detection of the Vibrio genus and five pathogenic Vibrio species with primer sets designed using comparative genomics. | Kim HJ, Ryu JO, Lee SY, Kim ES, Kim HY. | BMC Microbiol | 10.1186/s12866-015-0577-3 | 2015 | |
| Metabolism | Application of isothermal helicase-dependent amplification with a disposable detection device in a simple sensitive stool test for toxigenic Clostridium difficile. | Chow WH, McCloskey C, Tong Y, Hu L, You Q, Kelly CP, Kong H, Tang YW, Tang W. | J Mol Diagn | 10.2353/jmoldx.2008.080008 | 2008 | |
| Genetics | Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. | Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR. | Infect Immun | 10.1128/iai.71.5.2775-2786.2003 | 2003 | |
| Metabolism | Unc119 protects from Shigella infection by inhibiting the Abl family kinases. | Vepachedu R, Karim Z, Patel O, Goplen N, Alam R. | PLoS One | 10.1371/journal.pone.0005211 | 2009 | |
| Metabolism | GO4genome: a prokaryotic phylogeny based on genome organization. | Merkl R, Wiezer A. | J Mol Evol | 10.1007/s00239-009-9233-6 | 2009 | |
| Pathogenicity | Differential distribution of plasmid-mediated quinolone resistance genes in clinical enterobacteria with unusual phenotypes of quinolone susceptibility from Argentina. | Andres P, Lucero C, Soler-Bistue A, Guerriero L, Albornoz E, Tran T, Zorreguieta A, PMQR Group, Galas M, Corso A, Tolmasky ME, Petroni A. | Antimicrob Agents Chemother | 10.1128/aac.01615-12 | 2013 |
| #20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 ) |
| #41696 | Collection of Institut Pasteur ; Curators of the CIP; CIP 107659 |
| #66794 | Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 ) |
| #126262 | A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 ) |
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