Enterococcus faecium M74 is a facultative anaerobe, mesophilic, Gram-positive prokaryote that was isolated from Human, Faeces.
Gram-positive coccus-shaped facultative anaerobe mesophilic| @ref 20215 |
Last LPSN update
2025-12-16 10:03:09 |
| Domain Bacillati |
| Phylum Bacillota |
| Class Bacilli |
| Order Lactobacillales |
| Family Enterococcaceae |
| Genus Enterococcus |
| Species Enterococcus faecium |
| Full scientific name Enterococcus faecium (Orla-Jensen 1919) Schleifer and Kilpper-Bälz 1984 |
| Synonyms (1) |
| 40574 | Oxygen tolerancefacultative anaerobe |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68371 | 27613 ChEBI | amygdalin | + | builds acid from | from API 50CH acid |
| 68371 | 18305 ChEBI | arbutin | + | builds acid from | from API 50CH acid |
| 68371 | 17057 ChEBI | cellobiose | + | builds acid from | from API 50CH acid |
| 68371 | 17108 ChEBI | D-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18333 ChEBI | D-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 15824 ChEBI | D-fructose | + | builds acid from | from API 50CH acid |
| 68371 | 28847 ChEBI | D-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 12936 ChEBI | D-galactose | + | builds acid from | from API 50CH acid |
| 68371 | 17634 ChEBI | D-glucose | + | builds acid from | from API 50CH acid |
| 68371 | 62318 ChEBI | D-lyxose | - | builds acid from | from API 50CH acid |
| 68371 | 16899 ChEBI | D-mannitol | + | builds acid from | from API 50CH acid |
| 68371 | 16024 ChEBI | D-mannose | + | builds acid from | from API 50CH acid |
| 68371 | 16988 ChEBI | D-ribose | + | builds acid from | from API 50CH acid |
| 68371 | 17924 ChEBI | D-sorbitol | - | builds acid from | from API 50CH acid |
| 68371 | 16443 ChEBI | D-tagatose | + | builds acid from | from API 50CH acid |
| 68371 | 65327 ChEBI | D-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17113 ChEBI | erythritol | - | builds acid from | from API 50CH acid |
| 68371 | 4853 ChEBI | esculin | + | builds acid from | from API 50CH acid |
| 68371 | 16813 ChEBI | galactitol | - | builds acid from | from API 50CH acid |
| 68371 | 28066 ChEBI | gentiobiose | + | builds acid from | from API 50CH acid |
| 68371 | 24265 ChEBI | gluconate | - | builds acid from | from API 50CH acid |
| 68371 | 17754 ChEBI | glycerol | + | builds acid from | from API 50CH acid |
| 68371 | 28087 ChEBI | glycogen | - | builds acid from | from API 50CH acid |
| 68371 | 15443 ChEBI | inulin | - | builds acid from | from API 50CH acid |
| 68371 | 30849 ChEBI | L-arabinose | + | builds acid from | from API 50CH acid |
| 68371 | 18403 ChEBI | L-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 18287 ChEBI | L-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 62345 ChEBI | L-rhamnose | + | builds acid from | from API 50CH acid |
| 68371 | 17266 ChEBI | L-sorbose | - | builds acid from | from API 50CH acid |
| 68371 | 65328 ChEBI | L-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17716 ChEBI | lactose | + | builds acid from | from API 50CH acid |
| 68371 | 17306 ChEBI | maltose | + | builds acid from | from API 50CH acid |
| 68371 | 6731 ChEBI | melezitose | - | builds acid from | from API 50CH acid |
| 68371 | 320061 ChEBI | methyl alpha-D-glucopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 43943 ChEBI | methyl alpha-D-mannoside | - | builds acid from | from API 50CH acid |
| 68371 | 74863 ChEBI | methyl beta-D-xylopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 17268 ChEBI | myo-inositol | - | builds acid from | from API 50CH acid |
| 68371 | 59640 ChEBI | N-acetylglucosamine | + | builds acid from | from API 50CH acid |
| 40574 | 17632 ChEBI | nitrate | - | reduction | |
| 40574 | 16301 ChEBI | nitrite | - | reduction | |
| 68371 | Potassium 2-ketogluconate | - | builds acid from | from API 50CH acid | |
| 68371 | Potassium 5-ketogluconate | - | builds acid from | from API 50CH acid | |
| 68371 | 16634 ChEBI | raffinose | - | builds acid from | from API 50CH acid |
| 68371 | 15963 ChEBI | ribitol | - | builds acid from | from API 50CH acid |
| 68371 | 17814 ChEBI | salicin | + | builds acid from | from API 50CH acid |
| 68371 | 28017 ChEBI | starch | + | builds acid from | from API 50CH acid |
| 68371 | 17992 ChEBI | sucrose | + | builds acid from | from API 50CH acid |
| 68371 | 27082 ChEBI | trehalose | + | builds acid from | from API 50CH acid |
| 68371 | 32528 ChEBI | turanose | - | builds acid from | from API 50CH acid |
| 68371 | 17151 ChEBI | xylitol | - | builds acid from | from API 50CH acid |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 68382 | alkaline phosphatase | - | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | + | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 68382 | beta-galactosidase | + | 3.2.1.23 | from API zym |
| 68382 | beta-glucosidase | + | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 40574 | catalase | - | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | + | from API zym | |
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 68382 | lipase (C 14) | - | from API zym | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 40574 | oxidase | - | ||
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 40574 | urease | - | 3.5.1.5 | |
| 68382 | valine arylamidase | - | from API zym |
| @ref | ControlQ | GLY | ERY | DARA | LARA | RIB | DXYL | LXYL | ADO | MDX | GAL | GLU | FRU | MNE | SBE | RHA | DUL | INO | MAN | SOR | MDM | MDG | NAG | AMY | ARB | ESC | SAL | CEL | MAL | LAC | MEL | SAC | TRE | INU | MLZ | RAF | AMD | GLYG | XLT | GEN | TUR | LYX | TAG | DFUC | LFUC | DARL | LARL | GNT | 2KG | 5KG | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 40574 | not determinedn.d. | + | - | - | + | + | - | - | - | - | + | + | + | + | - | + | - | - | + | - | - | - | + | + | + | + | + | + | + | + | +/- | + | + | - | - | - | + | - | - | + | - | - | + | - | - | - | - | - | - | - |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Characterization of the chromosomal aac(6')-Ii gene specific for Enterococcus faecium. | Costa Y, Galimand M, Leclercq R, Duval J, Courvalin P. | Antimicrob Agents Chemother | 10.1128/aac.37.9.1896 | 1993 | | |
| Dietary Enterococcus faecium NCIMB 11181 supplementation mitigates intestinal and systemic inflammation induced by avian pathogenic Escherichia coli O78 infection in broiler chickens | Li P, Wu Y, Bi R, Cao C, Hu J, Chen X, Luo T, Wang Z. | Poultry Science. | 2025 | | ||
| Efficacy of a feed additive consisting of Enterococcus lactisNCIMB 11181 (Lactiferm®) for chickens for fattening or reared for laying, other poultry species for fattening or reared for laying and ornamental birds (Chr. Hansen A/S). | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, Lopez-Alonso M, Marcon F, Nebbia C, Pechova A, Prieto-Maradona M, Rohe I, Theodoridou K, Puente SL, Anguita M, Innocenti ML, Ortuno J. | EFSA J | 10.2903/j.efsa.2025.9680 | 2025 | | |
| Pathogenicity | Dietary Enterococcus faecium NCIMB 11181 supplementation mitigates intestinal and systemic inflammation induced by avian pathogenic Escherichia coli O78 infection in broiler chickens. | Li P, Wu Y, Bi R, Cao C, Hu J, Chen X, Luo T, Wang Z. | Poult Sci | 10.1016/j.psj.2025.105656 | 2025 | |
| Enterococcus faecium B13 Affects Mice Growth by Regulating Gut Microbiota and Metabolites | Luo F, Wu J, Wang S, Zhang M, Song Y, Lin Y. | Food Sci Nutr | 2025 | | ||
| Safety and efficacy of a feed additive consisting of Enterococcus lactis NCIMB 11181 (Lactiferm®) for chickens for fattening or reared for laying, other poultry species for fattening or reared for laying, and ornamental birds (Chr. Hansen A/S). | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Dusemund B, Kouba M, Lopez-Alonso M, Lopez Puente S, Marcon F, Mayo B, Pechova A, Petkova M, Ramos F, Villa RE, Woutersen R, Anguita M, Ortuno Casanova J, Pettenati E, Tarres-Call J. | EFSA J | 10.2903/j.efsa.2024.8623 | 2024 | | |
| Assessment of a feed additive containing Enterococcus lactis NCIMB 11181 (Lactiferm®) for weaned piglets, calves for fattening and calves for rearing for the renewal of its authorisation (Chr. Hansen A/S). | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Dusemund B, Kouba M, Lopez-Alonso M, Lopez Puente S, Marcon F, Mayo B, Pechova A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Saarela M, Anguita M, Brozzi R, Pettenati E, Pizzo F, Tarres-Call J. | EFSA J | 10.2903/j.efsa.2023.8466 | 2023 | | |
| Investigating the potential immunomodulatory effects of commercial oral probiotic supplements on equine gastrointestinal tract barrier function. | Zak-Bochenek A, Zebrowska-Rozanska P, Bajzert J, Laczmanski L, Szponar B, Siwinska N, Gladysz K, Sikorska K, Chelmonska-Soyta A. | Front Immunol | 10.3389/fimmu.2024.1487664 | 2024 | | |
| Effects of Enterococcus faecium SLB 130 probiotic on the performance of weaning pigs. | Sureshkumar S, Park JH, Kim IH. | Vet Med (Praha) | 10.17221/41/2022-vetmed | 2022 | | |
| Enterococcus faecalis strains derived from wild bird provide protection against Clostridium perfringens challenge in locally-sourced broilers. | Zhang G, Zahra A, Yang T, Guo Q, Sun Y, Zhang Y, Gao Y, Zhang Y, Wang M, Gong J, Huang H, Wang Z, Wang C, Jiang Y. | Front Vet Sci | 10.3389/fvets.2025.1601605 | 2025 | | |
| A Multi-Sensor Mini-Bioreactor to Preselect Silage Inoculants by Tracking Metabolic Activity in situ During Fermentation. | Shan G, Rosner V, Milimonka A, Buescher W, Lipski A, Maack C, Berchtold W, Wang Y, Grantz DA, Sun Y. | Front Microbiol | 10.3389/fmicb.2021.673795 | 2021 | | |
| Biotechnology | The Role of Whey in Functional Microorganism Growth and Metabolite Generation: A Biotechnological Perspective. | Malos IG, Ghizdareanu AI, Vidu L, Matei CB, Pasarin D. | Foods | 10.3390/foods14091488 | 2025 | |
| Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 18: Suitability of taxonomic units notified to EFSA until March 2023. | EFSA Panel on Biological Hazards (BIOHAZ), Koutsoumanis K, Allende A, Alvarez-Ordonez A, Bolton D, Bover-Cid S, Chemaly M, De Cesare A, Hilbert F, Lindqvist R, Nauta M, Nonno R, Peixe L, Ru G, Simmons M, Skandamis P, Suffredini E, Cocconcelli PS, Fernandez Escamez PS, Maradona MP, Querol A, Sijtsma L, Suarez JE, Sundh I, Barizzone F, Correia S, Herman L. | EFSA J | 10.2903/j.efsa.2023.8092 | 2023 | | |
| Effects of probiotic Enterococcus faecium NCIMB 11181 administration on swine fecal microbiota diversity and composition using barcoded pyrosequencing | Pajarillo EAB, Chae JP, Balolong MP, Kim HB, Park CS, Kang DK. | Anim Feed Sci Technol | 10.1016/j.anifeedsci.2015.01.011 | 2015 | | |
| Genetics | Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host. | Seishima J, Iida N, Kitamura K, Yutani M, Wang Z, Seki A, Yamashita T, Sakai Y, Honda M, Yamashita T, Kagaya T, Shirota Y, Fujinaga Y, Mizukoshi E, Kaneko S. | Genome Biol | 10.1186/s13059-019-1879-9 | 2019 | |
| Influence of Three Probiotics Strains, Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. Lactis BB-12 and Saccharomyces boulardii CNCM I-745 on the Biochemical and Haematological Profiles and Body Weight of Healthy Rabbits. | Kadja L, Dib AL, Lakhdara N, Bouaziz A, Espigares E, Gagaoua M. | Biology (Basel) | 10.3390/biology10111194 | 2021 | | |
| Probiotics as Alternatives to Antibiotics for the Prevention and Control of Necrotic Enteritis in Chickens. | Kulkarni RR, Gaghan C, Gorrell K, Sharif S, Taha-Abdelaziz K. | Pathogens | 10.3390/pathogens11060692 | 2022 | | |
| Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics. | Rajput DS, Zeng D, Khalique A, Rajput SS, Wang H, Zhao Y, Sun N, Ni X. | AMB Express | 10.1186/s13568-020-01153-w | 2020 | | |
| Probiotics mitigating subclinical necrotic enteritis (SNE) as potential alternatives to antibiotics in poultry. | Khalique A, Zeng D, Shoaib M, Wang H, Qing X, Rajput DS, Pan K, Ni X. | AMB Express | 10.1186/s13568-020-00989-6 | 2020 | | |
| Ramifications of Heat Stress on Rabbit Production and Role of Nutraceuticals in Alleviating Its Negative Impacts: An Updated Review. | Ebeid TA, Aljabeili HS, Al-Homidan IH, Volek Z, Barakat H. | Antioxidants (Basel) | 10.3390/antiox12071407 | 2023 | | |
| Metabolism | Dopamine production in Enterococcus faecium: A microbial endocrinology-based mechanism for the selection of probiotics based on neurochemical-producing potential. | Villageliu D, Lyte M. | PLoS One | 10.1371/journal.pone.0207038 | 2018 | |
| Isolation and in vitro assessment of chicken gut microbes for probiotic potential. | Shahbaz F, Muccee F, Shahab A, Safi SZ, Alomar SY, Qadeer A. | Front Microbiol | 10.3389/fmicb.2024.1278439 | 2024 | | |
| Phylogeny | Piglet gut microbial shifts early in life: causes and effects. | Guevarra RB, Lee JH, Lee SH, Seok MJ, Kim DW, Kang BN, Johnson TJ, Isaacson RE, Kim HB. | J Anim Sci Biotechnol | 10.1186/s40104-018-0308-3 | 2019 | |
| The Effect of Recently Developed Synbiotic Preparations on Dominant Fecal Microbiota and Organic Acids Concentrations in Feces of Piglets from Nursing to Fattening. | Chlebicz-Wojcik A, Slizewska K. | Animals (Basel) | 10.3390/ani10111999 | 2020 | | |
| Bacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review). | Jenab A, Roghanian R, Emtiazi G. | Drug Des Devel Ther | 10.2147/dddt.s261283 | 2020 | | |
| Clostridium perfringens as Foodborne Pathogen in Broiler Production: Pathophysiology and Potential Strategies for Controlling Necrotic Enteritis. | Mora ZV, Macias-Rodriguez ME, Arratia-Quijada J, Gonzalez-Torres YS, Nuno K, Villarruel-Lopez A. | Animals (Basel) | 10.3390/ani10091718 | 2020 | | |
| Fecal microbiota colonization dynamics in dairy heifers associated with early-life rumen microbiota modulation and gut health. | Huuki H, Vilkki J, Vanhatalo A, Tapio I. | Front Microbiol | 10.3389/fmicb.2024.1353874 | 2024 | | |
| Response of Growth Performance, Blood Biochemistry Indices, and Rumen Bacterial Diversity in Lambs to Diets Containing Supplemental Probiotics and Chinese Medicine Polysaccharides. | Chen H, Guo B, Yang M, Luo J, Hu Y, Qu M, Song X. | Front Vet Sci | 10.3389/fvets.2021.681389 | 2021 | | |
| Current Status of the Preharvest Application of Pro- and Prebiotics to Farm Animals to Enhance the Microbial Safety of Animal Products. | Joerger RD, Ganguly A. | Microbiol Spectr | 10.1128/microbiolspec.pfs-0012-2016 | 2017 | | |
| Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections. | Lamichhane B, Mawad AMM, Saleh M, Kelley WG, Harrington PJ, Lovestad CW, Amezcua J, Sarhan MM, El Zowalaty ME, Ramadan H, Morgan M, Helmy YA. | Antibiotics (Basel) | 10.3390/antibiotics13010076 | 2024 | | |
| Pathogenicity | Effect of dietary Lactobacilli mixture on Listeria monocytogenes infection and virulence property in broilers. | Deng Q, Shi H, Luo Y, Zhao H, Liu N. | Poult Sci | 10.1016/j.psj.2020.03.058 | 2020 | |
| Evaluation of the in-field efficacy of oregano essential oil administration on the control of neonatal diarrhea syndrome in calves. | Katsoulos PD, Karatzia MA, Dovas CI, Filioussis G, Papadopoulos E, Kiossis E, Arsenopoulos K, Papadopoulos T, Boscos C, Karatzias H. | Res Vet Sci | 10.1016/j.rvsc.2017.07.029 | 2017 | | |
| Comparison of Biogenic Amines and Mycotoxins in Alfalfa and Red Clover Fodder Depending on Additives. | Skladanka J, Adam V, Zitka O, Mlejnkova V, Kalhotka L, Horky P, Konecna K, Hodulikova L, Knotova D, Balabanova M, Slama P, Skarpa P. | Int J Environ Res Public Health | 10.3390/ijerph14040418 | 2017 | | |
| Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs. | Shin D, Chang SY, Bogere P, Won K, Choi JY, Choi YJ, Lee HK, Hur J, Park BY, Kim Y, Heo J. | PLoS One | 10.1371/journal.pone.0220843 | 2019 | | |
| Antimicrobial Resistance and Recent Alternatives to Antibiotics for the Control of Bacterial Pathogens with an Emphasis on Foodborne Pathogens. | Helmy YA, Taha-Abdelaziz K, Hawwas HAE, Ghosh S, AlKafaas SS, Moawad MMM, Saied EM, Kassem II, Mawad AMM. | Antibiotics (Basel) | 10.3390/antibiotics12020274 | 2023 | | |
| Enzymology | Recovery of probiotic bacteria from the intestinal tract of broilers after noninvasive pre-hatch application. | Thofner I, Sandvang D, Aagaard K, Poulsen LL | Benef Microbes | 10.3920/BM2020.0227 | 2021 | |
| Metabolism | Pretreatment with probiotic Enterococcus faecium NCIMB 11181 ameliorates necrotic enteritis-induced intestinal barrier injury in broiler chickens. | Wu Y, Zhen W, Geng Y, Wang Z, Guo Y | Sci Rep | 10.1038/s41598-019-46578-x | 2019 | |
| Effects of dietary Enterococcus faecium NCIMB 11181 supplementation on growth performance and cellular and humoral immune responses in broiler chickens. | Wu Y, Zhen W, Geng Y, Wang Z, Guo Y | Poult Sci | 10.3382/ps/pey368 | 2019 | | |
| Pathogenicity | Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens. | Huang L, Luo L, Zhang Y, Wang Z, Xia Z | Probiotics Antimicrob Proteins | 10.1007/s12602-018-9434-7 | 2019 | |
| Transcriptome | Revealing the combined effects of lactulose and probiotic enterococci on the swine faecal microbiota using 454 pyrosequencing. | Chae JP, Pajarillo EA, Oh JK, Kim H, Kang DK | Microb Biotechnol | 10.1111/1751-7915.12370 | 2016 | |
| A newly developed strain of Enterococcus faecium isolated from fresh dairy products to be used as a probiotic in lactating Holstein cows. | Azzaz HH, Kholif AE, Murad HA, Vargas-Bello-Perez E | Front Vet Sci | 10.3389/fvets.2022.989606 | 2022 | | |
| Pretreatment with probiotics Enterococcus faecium NCIMB 11181 attenuated Salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses with barrier function in broiler chickens. | Shao Y, Zhen W, Guo F, Hu Z, Zhang K, Kong L, Guo Y, Wang Z | J Anim Sci Biotechnol | 10.1186/s40104-022-00765-5 | 2022 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive138782.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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