Helicobacter felis (CIP 104084, ATCC 49179, CCUG 28539)

Name: Helicobacter felis (CIP 104084, ATCC 49179, CCUG 28539)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 138426

Type strain

Strain Designation CS1

Culture col. no. CIP 104084 ATCC 49179 CCUG 28539 NCTC 12482 CIP 104382 1 more

NCBI tax ID(s) 936155 214

Special Collections CCUG CIP

History CIP <- 1994, R.L. Ferrero, Inst. Pasteur, Paris, France <- A. Lee: strain CS1

Links

Helicobacter felis CS1 is a Gram-negative, motile, rod-shaped bacterium of the family Helicobacteraceae.

Gram-negative motile rod-shaped genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 42337

ATCC 49179,CCUG 28539,CIP 104382,NCTC 12482,NCTC 12436,CIP 104084

@ref 20215

Last LPSN update 2026-05-29 08:39:16

Domain Bacteria

Phylum Pseudomonadota

Class Epsilonproteobacteria

Order Campylobacterales

Family Helicobacteraceae

Genus Helicobacter

Species Helicobacter felis

Full scientific name Helicobacter felis Paster et al. 1991

BacDive ID	Other strains from **Helicobacter felis** (1)	Type strain
135394	H. felis CS6, CIP 104083, ATCC 51211

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
39710	negative	rod-shaped
125438	negative			97.477

Culture and growth conditions

Culture medium

@ref	Name	Composition	Medium link
39710	MEDIUM 45 - for Columbia agar with sheep blood	Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Sheepblood (100.000 ml)
39710	CIP Medium 45		Medium recipe at CIP
39710	CIP Medium 6		Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
39710	positive	growth	37

Physiology and metabolism

Spore formation

@ref	Spore formation	Confidence
39710
125438		94.532
125439		98.64

Isolation, sampling and environmental information

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent	Isolation date
39710		Sydney	Australia	AUS	Australia and Oceania
39710	Animal, Cat, gastric mucosa	Sydney, New South Wales	Australia	AUS	Australia and Oceania	1987

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
39710	2	Risk group (French classification)

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM20059v1 assembly for Helicobacter felis ATCC 49179	complete	GCA_000200595	936155.3	649633054	936155	98.98

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
124043	Helicobacter felis strain CS1 16S ribosomal RNA gene, complete sequence.	M57398	1474		936155

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM20059v1 assembly for Helicobacter felis ATCC 49179
BV-BRC: 936155.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	89.93	no
125439	gram_stain	BacteriaNetⓘ	negative	76.83	no
125439	motility	BacteriaNetⓘ	no	83.80	no
125439	spore_formation	BacteriaNetⓘ	no	98.64	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Helicobacter felis ATCC 49179 ATCC 49179
NCBI: GCA_000200595.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	97.48	no
125438	anaerobic	anaerobicⓘ	no	75.84	no
125438	aerobic	aerobicⓘ	no	89.02	no
125438	spore-forming	spore-formingⓘ	no	94.53	no
125438	thermophilic	thermophileⓘ	no	83.00	yes
125438	flagellated	motile2+ⓘ	no	52.10	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Protocol to establish an accelerated murine model for Helicobacter-induced gastric cancer.	Bali P, Lozano-Pope I, Hernandez J, Estrada MV, Benner C, Obonyo M.	STAR Protoc	10.1016/j.xpro.2024.103302	2024
Pathogenicity	Chronic Infection With Gastric Helicobacters Induces Hepatic Lesions in Mice.	Seeneevassen L, Sifre E, Khalid S, Managau M, Megraud F, Menard A, Dubus P, Spuul P, Varon C.	Helicobacter	10.1111/hel.70032	2025
Pathogenicity	Comparison of gastric inflammation and metaplasia induced by Helicobacter pylori or Helicobacter felis colonization in mice.	Druffner SR, Venkateshwaraprabu S, Khadka S, Duncan BC, Morris MT, Sen-Kilic E, Damron FH, Liechti GW, Busada JT.	Microbiol Spectr	10.1128/spectrum.00015-24	2024
	Endogenous glucocorticoids are required for normal macrophage activation and gastric Helicobacter pylori immunity.	Khadka S, Dziadowicz SA, Xu X, Wang L, Hu G, Carrero JA, DiPaolo RJ, Busada JT.	Am J Physiol Gastrointest Liver Physiol	10.1152/ajpgi.00114.2024	2024
	TRIF-IFN-I pathway in Helicobacter-induced gastric cancer in an accelerated murine disease model and patient biopsies.	Bali P, Lozano-Pope I, Hernandez J, Estrada MV, Corr M, Turner MA, Bouvet M, Benner C, Obonyo M.	iScience	10.1016/j.isci.2024.109457	2024
Metabolism	Silk fibroin hydrogel as mucosal vaccine carrier: induction of gastric CD4+TRM cells mediated by inflammatory response induces optimal immune protection against Helicobacter felis.	Hu C, Liu W, Xu N, Huang A, Zhang Z, Fan M, Ruan G, Wang Y, Xi T, Xing Y.	Emerg Microbes Infect	10.1080/22221751.2020.1830719	2020
Genetics	Whole-Genome Sequencing and Bioinformatics as Pertinent Tools to Support Helicobacteracae Taxonomy, Based on Three Strains Suspected to Belong to Novel Helicobacter Species.	Berthenet E, Benejat L, Menard A, Varon C, Lacomme S, Gontier E, Raymond J, Boussaba O, Toulza O, Ducournau A, Buissonniere A, Giese A, Megraud F, Bessede E, Jehanne Q, Lehours P.	Front Microbiol	10.3389/fmicb.2019.02820	2019
Pathogenicity	Anti-inflammatory and Anti-tumorigenic Effects of Açai Berry in Helicobacter felis-infected mice.	Lee JY, Kim N, Choi YJ, Nam RH, Lee S, Ham MH, Suh JH, Choi YJ, Lee HS, Lee DH.	J Cancer Prev	10.15430/jcp.2016.21.1.48	2016
	Effect of N-Methyl-N-Nitrosourea on Helicobacter-induced Gastric Carcinogenesis in C57BL/6 Mice.	Lee JY, Kim N, Choi YJ, Nam RH, Choi YJ, Lee S, Choi D, Lee HS, Kim JW, Lee DH.	J Cancer Prev	10.15430/jcp.2016.21.3.182	2016
	Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo-YAP1 pathway.	Liu D, Liu Y, Zhu W, Lu Y, Zhu J, Ma X, Xing Y, Yuan M, Ning B, Wang Y, Jia Y.	BMC Med	10.1186/s12916-023-02842-6	2023
Pathogenicity	Histologic Findings and Inflammatory Reactions After Long-term Colonization of Helicobacter felis in C57BL/6 Mice.	Lee JY, Kim N, Choi YJ, Nam RH, Choi YJ, Kwon YH, Yoon K, Suh JH, Lee SM, Lee HS, Lee DH.	J Cancer Prev	10.15430/jcp.2014.19.3.224	2014
	Helicobacter-induced gastric inflammation alters the properties of gastric tissue stem/progenitor cells.	Shibata W, Sue S, Tsumura S, Ishii Y, Sato T, Kameta E, Sugimori M, Yamada H, Kaneko H, Sasaki T, Ishii T, Tamura T, Kondo M, Maeda S.	BMC Gastroenterol	10.1186/s12876-017-0706-6	2017
	A mixed population of Helicobacter pylori, Helicobacter bizzozeronii and "Helicobacter heilmannii" in the gastric mucosa of a domestic cat.	Canejo-Teixeira R, Oliveira M, Pissarra H, Niza MM, Vilela CL.	Ir Vet J	10.1186/2046-0481-67-25	2014
	Microbiome Signatures in a Fast- and Slow-Progressing Gastric Cancer Murine Model and Their Contribution to Gastric Carcinogenesis.	Bali P, Coker J, Lozano-Pope I, Zengler K, Obonyo M.	Microorganisms	10.3390/microorganisms9010189	2021
Phylogeny	Comparative analysis of prophage-like elements in Helicobacter sp. genomes.	Fan X, Li Y, He R, Li Q, He W.	PeerJ	10.7717/peerj.2012	2016
	Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice.	Lemos LM, Miyajima F, Castilho GR, Martins DT, Pritchard DM, Burkitt MD.	Front Pharmacol	10.3389/fphar.2017.00092	2017
Metabolism	Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection.	Esposito R, Morello S, Vllahu M, Eletto D, Porta A, Tosco A.	Front Cell Infect Microbiol	10.3389/fcimb.2017.00434	2017
	The validity evaluation of different 16srRNA gene primers for helicobacter detection urgently requesting to design new specific primers.	Abdelmalek S, Shokry K, Hamed W, Abdelnaser M, Aboubakr A, Elenin SA, Ali M, Mostafa M, Abou-Okada M.	Sci Rep	10.1038/s41598-022-14600-4	2022
	Molecular and clinical analyses of Helicobacter pylori colonization in inflamed dental pulp.	Nomura R, Ogaya Y, Matayoshi S, Morita Y, Nakano K.	BMC Oral Health	10.1186/s12903-018-0526-2	2018
Metabolism	TET repression and increased DNMT activity synergistically induce aberrant DNA methylation.	Takeshima H, Niwa T, Yamashita S, Takamura-Enya T, Iida N, Wakabayashi M, Nanjo S, Abe M, Sugiyama T, Kim YJ, Ushijima T.	J Clin Invest	10.1172/jci124070	2020
	Gastric Helicobacter species associated with dogs, cats and pigs: significance for public and animal health.	Taillieu E, Chiers K, Amorim I, Gartner F, Maes D, Van Steenkiste C, Haesebrouck F.	Vet Res	10.1186/s13567-022-01059-4	2022
Enzymology	Determination of the prevalence of Helicobacter heilmannii-like organisms type 2 (HHLO-2) infection in humans and dogs using non-invasive genus/species-specific PCR in Korea.	Chung TH, Kim HD, Lee YS, Hwang CY.	J Vet Med Sci	10.1292/jvms.13-0223	2014
	Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen Helicobacter felis.	Arnold IC, Zigova Z, Holden M, Lawley TD, Rad R, Dougan G, Falkow S, Bentley SD, Muller A.	Genome Biol Evol	10.1093/gbe/evr022	2011
	Activation of Signal Transduction and Activator of Transcription 3 Signaling Contributes to Helicobacter-Associated Gastric Epithelial Proliferation and Inflammation.	Ishii Y, Shibata W, Sugimori M, Kaneta Y, Kanno M, Sato T, Sue S, Kameta E, Kaneko H, Irie K, Sasaki T, Kondo M, Maeda S.	Gastroenterol Res Pract	10.1155/2018/9050715	2018
	Anti-CD40L therapy prevents the formation of precursor lesions to gastric B-cell MALT lymphoma in a mouse model.	Ying L, Liu P, Ding Z, Wray-McCann G, Emery J, Colon N, Le LH, Tran LS, Xu P, Yu L, Philpott DJ, Tu Y, Cheah DM, Cheng CL, Lim ST, Ong CK, Ferrero RL.	J Pathol	10.1002/path.6053	2023
	The temperature-dependent expression of type II secretion system controls extracellular product secretion and virulence in mesophilic Aeromonas salmonida SRW-OG1.	Yi X, Chen Y, Cai H, Wang J, Zhang Y, Zhu Z, Lin M, Qin Y, Jiang X, Xu X.	Front Cell Infect Microbiol	10.3389/fcimb.2022.945000	2022
Enzymology	Evaluation of a Novel Stool Antigen Rapid Test Kit for Detection of Helicobacter pylori Infection.	Kakiuchi T, Okuda M, Hashiguchi K, Imamura I, Nakayama A, Matsuo M.	J Clin Microbiol	10.1128/jcm.01825-18	2019
	Bone marrow-derived cells may not be the original cells for carcinogen-induced mouse gastrointestinal carcinomas.	Yang C, Gu L, Deng D.	PLoS One	10.1371/journal.pone.0079615	2013
	The Genus Iris Tourn. ex L.: Updates on Botany, Cultivation, Novel Niches and Impactful Applications.	Crisan I.	Plants (Basel)	10.3390/plants14182870	2025
	Role of Inflammatory Monocytes in Vaccine-Induced Reduction of Helicobacter felis Infection.	Moyat M, Mack M, Bouzourene H, Velin D.	Infect Immun	10.1128/iai.01026-15	2015
	Survey of Helicobacter infection in domestic and feral cats in Korea.	Ghil HM, Yoo JH, Jung WS, Chung TH, Youn HY, Hwang CY.	J Vet Sci	10.4142/jvs.2009.10.1.67	2009
Metabolism	Evolution of Helicobacter: Acquisition by Gastric Species of Two Histidine-Rich Proteins Essential for Colonization.	Vinella D, Fischer F, Vorontsov E, Gallaud J, Malosse C, Michel V, Cavazza C, Robbe-Saule M, Richaud P, Chamot-Rooke J, Brochier-Armanet C, De Reuse H.	PLoS Pathog	10.1371/journal.ppat.1005312	2015
Pathogenicity	The bactericidal effects of Lactobacillus acidophilus, garcinol and Protykin compared to clarithromycin, on Helicobacter pylori.	Chatterjee A, Yasmin T, Bagchi D, Stohs SJ.	Mol Cell Biochem	10.1023/a:1021649427988	2003
	bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice.	Duckworth CA, Abuderman AA, Burkitt MD, Williams JM, O'Reilly LA, Pritchard DM.	Am J Physiol Gastrointest Liver Physiol	10.1152/ajpgi.00404.2014	2015
Metabolism	Gastric Helicobacter infection induces iron deficiency in the INS-GAS mouse.	Thomson MJ, Pritchard DM, Boxall SA, Abuderman AA, Williams JM, Varro A, Crabtree JE.	PLoS One	10.1371/journal.pone.0050194	2012
Phylogeny	Whole genome-based phylogeny of reptile-associated Helicobacter indicates independent niche adaptation followed by diversification in a poikilothermic host.	Gilbert MJ, Duim B, Timmerman AJ, Zomer AL, Wagenaar JA.	Sci Rep	10.1038/s41598-017-09091-7	2017
	Incidence of Helicobacter felis and the effect of coinfection with Helicobacter pylori on the gastric mucosa in the African population.	Fritz EL, Slavik T, Delport W, Olivier B, van der Merwe SW.	J Clin Microbiol	10.1128/jcm.44.5.1692-1696.2006	2006
Enzymology	Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia.	Yakoob J, Abbas Z, Khan R, Naz S, Ahmad Z, Islam M, Awan S, Jafri F, Jafri W.	BMC Gastroenterol	10.1186/1471-230x-12-3	2012
Phylogeny	A Potential New Human Pathogen Belonging to Helicobacter Genus, Identified in a Bloodstream Infection.	van der Mee-Marquet NL, Benejat L, Diene SM, Lemaignen A, Gaia N, Smet A, Haesebrouck F, Cherkaoui A, Ducournau A, Lacomme S, Gontier E, Bernard L, Megraud F, Goudeau A, Lehours P, Francois P.	Front Microbiol	10.3389/fmicb.2017.02533	2017
	Use of the cockroach antigen model of acute asthma to determine the immunomodulatory role of early exposure to gastrointestinal infection.	Durham CG, Schwiebert LM, Lorenz RG.	Methods Mol Biol	10.1007/978-1-62703-496-8_21	2013
Metabolism	Programmed Death Ligand 1-Expressing Classical Dendritic Cells MitigateHelicobacter-Induced Gastritis.	Go DM, Lee SH, Lee SH, Woo SH, Kim K, Kim K, Park KS, Park JH, Ha SJ, Kim WH, Choi JH, Kim DY.	Cell Mol Gastroenterol Hepatol	10.1016/j.jcmgh.2021.04.007	2021
Metabolism	Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice.	Kenny S, Gamble J, Lyons S, Vlatkovic N, Dimaline R, Varro A, Dockray GJ.	Endocrinology	10.1210/en.2012-1913	2013
Phylogeny	Diagnosis of Genus Helicobacter through a hemi-nested PCR assay of 16S rRNA.	Qin H, Tang G, Yi P, Pan X, Huang H, Chang R, Shi Z, Ashraf MA.	Saudi Pharm J	10.1016/j.jsps.2016.04.015	2016
	Helicobacter felis--associated gastric disease in microbiota-restricted mice.	Schmitz JM, Durham CG, Schoeb TR, Soltau TD, Wolf KJ, Tanner SM, McCracken VJ, Lorenz RG.	J Histochem Cytochem	10.1369/0022155411416242	2011
	Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis.	Chang W, Wang H, Kim W, Liu Y, Deng H, Liu H, Jiang Z, Niu Z, Sheng W, Napoles OC, Sun Y, Xu J, Sepulveda A, Hayakawa Y, Bass AJ, Wang TC.	Cell Stem Cell	10.1016/j.stem.2020.01.020	2020
	Mucosal immunization with helicobacter, CpG DNA, and cholera toxin is protective.	Jiang W, Baker HJ, Smith BF.	Infect Immun	10.1128/iai.71.1.40-46.2003	2003
	Fibroblastic colony-forming unit bone marrow cells delay progression to gastric dysplasia in a helicobacter model of gastric tumorigenesis.	Wang SS, Asfaha S, Okumura T, Betz KS, Muthupalani S, Rogers AB, Tu S, Takaishi S, Jin G, Yang X, Wu DC, Fox JG, Wang TC.	Stem Cells	10.1002/stem.165	2009
	Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response.	Obonyo M, Rickman B, Guiney DG.	Helicobacter	10.1111/j.1523-5378.2011.00861.x	2011
	Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses.	Kurt-Jones EA, Cao L, Sandor F, Rogers AB, Whary MT, Nambiar PR, Cerny A, Bowen G, Yan J, Takaishi S, Chi AL, Reed G, Houghton J, Fox JG, Wang TC.	Infect Immun	10.1128/iai.02039-05	2007
	K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia.	Okumura T, Ericksen RE, Takaishi S, Wang SS, Dubeykovskiy Z, Shibata W, Betz KS, Muthupalani S, Rogers AB, Fox JG, Rustgi AK, Wang TC.	Cancer Res	10.1158/0008-5472.can-10-1506	2010
	Production and application of new monoclonal antibodies specific for a fecal Helicobacter pylori antigen.	Suzuki N, Wakasugi M, Nakaya S, Okada K, Mochida R, Sato M, Kajiyama H, Takahashi R, Hirata H, Ezure Y, Koga Y, Fukuda Y, Shimoyama T.	Clin Diagn Lab Immunol	10.1128/cdli.9.1.75-78.2002	2002
Phylogeny	Discordant 16S and 23S rRNA gene phylogenies for the genus Helicobacter: implications for phylogenetic inference and systematics.	Dewhirst FE, Shen Z, Scimeca MS, Stokes LN, Boumenna T, Chen T, Paster BJ, Fox JG.	J Bacteriol	10.1128/jb.187.17.6106-6118.2005	2005
Metabolism	Effect of purified lipopolysaccharides from strains of Helicobacter pylori and Helicobacter felis on acid secretion in mouse gastric glands in vitro.	Padol IT, Moran AP, Hunt RH.	Infect Immun	10.1128/iai.69.6.3891-3896.2001	2001
Metabolism	NF-kappaB activation during acute Helicobacter pylori infection in mice.	Ferrero RL, Ave P, Ndiaye D, Bambou JC, Huerre MR, Philpott DJ, Memet S.	Infect Immun	10.1128/iai.01107-07	2008
	Lengths of Orthologous Prokaryotic Proteins Are Affected by Evolutionary Factors.	Tatarinova T, Salih B, Dien Bard J, Cohen I, Bolshoy A.	Biomed Res Int	10.1155/2015/786861	2015
	Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer.	Lozano-Pope I, Sharma A, Matthias M, Doran KS, Obonyo M.	BMC Cancer	10.1186/s12885-017-3114-y	2017
	Post-immunisation gastritis and Helicobacter infection in the mouse: a long term study.	Sutton P, Danon SJ, Walker M, Thompson LJ, Wilson J, Kosaka T, Lee A.	Gut	10.1136/gut.49.4.467	2001
Metabolism	Gastric mucus alterations associated with murine Helicobacter infection.	Schmitz JM, Durham CG, Ho SB, Lorenz RG.	J Histochem Cytochem	10.1369/jhc.2009.952473	2009
Metabolism	Prokaryotic viperins produce diverse antiviral molecules.	Bernheim A, Millman A, Ofir G, Meitav G, Avraham C, Avraham C, Shomar H, Rosenberg MM, Tal N, Melamed S, Amitai G, Sorek R.	Nature	10.1038/s41586-020-2762-2	2021
Metabolism	Deficiency of the myeloid differentiation primary response molecule MyD88 leads to an early and rapid development of Helicobacter-induced gastric malignancy.	Banerjee A, Thamphiwatana S, Carmona EM, Rickman B, Doran KS, Obonyo M.	Infect Immun	10.1128/iai.01344-13	2014
	The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of helicobacter-induced mucosa-associated lymphoid tissue lymphoma.	Mueller A, O'rourke J, Chu P, Chu A, Dixon MF, Bouley DM, Lee A, Falkow S.	Am J Pathol	10.1016/s0002-9440(10)62052-4	2005
	MALToma-like lesions in the murine gastric mucosa after long-term infection with Helicobacter felis. A mouse model of Helicobacter pylori-induced gastric lymphoma.	Enno A, O'Rourke JL, Howlett CR, Jack A, Dixon MF, Lee A.	Am J Pathol		1995
Enzymology	Specific detection of Arcobacter and Campylobacter strains in water and sewage by PCR and fluorescent in situ hybridization.	Moreno Y, Botella S, Alonso JL, Ferrus MA, Hernandez M, Hernandez J.	Appl Environ Microbiol	10.1128/aem.69.2.1181-1186.2003	2003
Enzymology	Catalase, a specific antigen in the feces of human subjects infected with Helicobacter pylori.	Suzuki N, Wakasugi M, Nakaya S, Kokubo N, Sato M, Kajiyama H, Takahashi R, Hirata H, Ezure Y, Fukuda Y, Shimoyama T.	Clin Diagn Lab Immunol	10.1128/cdli.9.4.784-788.2002	2002
	Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis.	Sakagami T, Dixon M, O'Rourke J, Howlett R, Alderuccio F, Vella J, Shimoyama T, Lee A.	Gut	10.1136/gut.39.5.639	1996
Metabolism	Properties of the P-type ATPases encoded by the copAP operons of Helicobacter pylori and Helicobacter felis.	Bayle D, Wangler S, Weitzenegger T, Steinhilber W, Volz J, Przybylski M, Schafer KP, Sachs G, Melchers K.	J Bacteriol	10.1128/jb.180.2.317-329.1998	1998
Metabolism	Helicobacter pylori promotes the production of thymic stromal lymphopoietin by gastric epithelial cells and induces dendritic cell-mediated inflammatory Th2 responses.	Kido M, Tanaka J, Aoki N, Iwamoto S, Nishiura H, Chiba T, Watanabe N.	Infect Immun	10.1128/iai.00762-09	2010
Enzymology	Urease-encoding genes in ammonia-oxidizing bacteria.	Koper TE, El-Sheikh AF, Norton JM, Klotz MG.	Appl Environ Microbiol	10.1128/aem.70.4.2342-2348.2004	2004
Metabolism	Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4.	Mandell L, Moran AP, Cocchiarella A, Houghton J, Taylor N, Fox JG, Wang TC, Kurt-Jones EA.	Infect Immun	10.1128/iai.72.11.6446-6454.2004	2004
	Effect of oral immunization with recombinant urease on murine Helicobacter felis gastritis.	Pappo J, Thomas WD, Kabok Z, Taylor NS, Murphy JC, Fox JG.	Infect Immun	10.1128/iai.63.4.1246-1252.1995	1995
Metabolism	Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium.	Okumura T, Wang SS, Takaishi S, Tu SP, Ng V, Ericksen RE, Rustgi AK, Wang TC.	Lab Invest	10.1038/labinvest.2009.88	2009
Phylogeny	Development of a real-time fluorescence resonance energy transfer PCR to detect arcobacter species.	Abdelbaqi K, Buissonniere A, Prouzet-Mauleon V, Gresser J, Wesley I, Megraud F, Menard A.	J Clin Microbiol	10.1128/jcm.00256-07	2007
	Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10(-/-) mice.	Berg DJ, Lynch NA, Lynch RG, Lauricella DM.	Am J Pathol		1998
Enzymology	Gastric helicobacters in cats.	Lecoindre P, Chevallier M, Peyrol S, Boude M, Ferrero RL, Labigne A.	J Feline Med Surg	10.1053/jfms.2000.0063	2000
	Recombinant antigens prepared from the urease subunits of Helicobacter spp.: evidence of protection in a mouse model of gastric infection.	Ferrero RL, Thiberge JM, Huerre M, Labigne A.	Infect Immun	10.1128/iai.62.11.4981-4989.1994	1994
	Replication-defective adenovirus infection reduces Helicobacter felis colonization in the mouse in a gamma interferon- and interleukin-12-dependent manner.	Jiang B, Jordana M, Xing Z, Smaill F, Snider DP, Borojevic R, Steele-Norwood D, Hunt RH, Croitoru K.	Infect Immun	10.1128/iai.67.9.4539-4544.1999	1999
Enzymology	Characterization of a culturable "Gastrospirillum hominis" (Helicobacter heilmannii) strain isolated from human gastric mucosa.	Andersen LP, Boye K, Blom J, Holck S, Norgaard A, Elsborg L.	J Clin Microbiol	10.1128/jcm.37.4.1069-1076.1999	1999
Metabolism	Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells.	Azzi-Martin L, He W, Pere-Vedrenne C, Korolik V, Alix C, Prochazkova-Carlotti M, Morel JL, Le Roux-Goglin E, Lehours P, Djavaheri-Mergny M, Grosset CF, Varon C, Dubus P, Menard A.	PLoS Pathog	10.1371/journal.ppat.1007921	2019
	Successful immunization against gastric infection with Helicobacter species: use of a cholera toxin B-subunit-whole-cell vaccine.	Lee A, Chen M.	Infect Immun	10.1128/iai.62.8.3594-3597.1994	1994
Enzymology	Partial characterization and effect of omeprazole on ATPase activity in Helicobacter pylori by using permeabilized cells.	Belli WA, Fryklund J.	Antimicrob Agents Chemother	10.1128/aac.39.8.1717	1995
Metabolism	Expression of intrinsic factor in rat and murine gastric mucosal cell lineages is modified by inflammation.	Shao J, Sartor RB, Dial E, Lichtenberger LM, Schepp W, Alpers DH.	Am J Pathol	10.1016/s0002-9440(10)64635-4	2000
Metabolism	Role for complement in development of Helicobacter-induced gastritis in interleukin-10-deficient mice.	Ismail HF, Zhang J, Lynch RG, Wang Y, Berg DJ.	Infect Immun	10.1128/iai.71.12.7140-7148.2003	2003
Metabolism	Identification of gastric cancer stem cells using the cell surface marker CD44.	Takaishi S, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC.	Stem Cells	10.1002/stem.30	2009
	A genetic basis for atrophy: dominant non-responsiveness and helicobacter induced gastritis in F(1) hybrid mice.	Sutton P, Wilson J, Genta R, Torrey D, Savinainen A, Pappo J, Lee A.	Gut	10.1136/gut.45.3.335	1999
	Urease-specific monoclonal antibodies prevent Helicobacter felis infection in mice.	Blanchard TG, Czinn SJ, Maurer R, Thomas WD, Soman G, Nedrud JG.	Infect Immun	10.1128/iai.63.4.1394-1399.1995	1995
Enzymology	Specific detection and prevalence of Helicobacter heilmannii-like organisms in the human gastric mucosa by fluorescent in situ hybridization and partial 16S ribosomal DNA sequencing.	Trebesius K, Adler K, Vieth M, Stolte M, Haas R.	J Clin Microbiol	10.1128/jcm.39.4.1510-1516.2001	2001
Phylogeny	Detection of Helicobacter pylori in gastric mucosa of patients with gastroduodenal diseases by PCR-restriction analysis using the RNA polymerase gene (rpoB).	Lim CY, Lee KH, Cho MJ, Chang MW, Kim SY, Myong NH, Lee WK, Rhee KH, Kook YH.	J Clin Microbiol	10.1128/jcm.41.7.3387-3391.2003	2003
	Antigen-dependent progression of mucosa-associated lymphoid tissue (MALT)-type lymphoma in the stomach. Effects of antimicrobial therapy on gastric MALT lymphoma in mice.	Enno A, O'Rourke J, Braye S, Howlett R, Lee A.	Am J Pathol		1998
	Methods of combinatorial optimization to reveal factors affecting gene length.	Bolshoy A, Tatarinova T.	Bioinform Biol Insights	10.4137/bbi.s10525	2012
	Transmission of Helicobacter spp. A challenge to the dogma of faecal-oral spread.	Lee A, Fox JG, Otto G, Dick EH, Krakowka S.	Epidemiol Infect	10.1017/s095026880004872x	1991
	The endotoxin of Helicobacter pylori is a modulator of host-dependent gastritis.	Sakagami T, Vella J, Dixon MF, O'Rourke J, Radcliff F, Sutton P, Shimoyama T, Beagley K, Lee A.	Infect Immun	10.1128/iai.65.8.3310-3316.1997	1997
	Helicobacter felis gastritis in gnotobiotic rats: an animal model of Helicobacter pylori gastritis.	Fox JG, Lee A, Otto G, Taylor NS, Murphy JC.	Infect Immun	10.1128/iai.59.3.785-791.1991	1991
	Local and systemic immune responses in murine Helicobacter felis active chronic gastritis.	Fox JG, Blanco M, Murphy JC, Taylor NS, Lee A, Kabok Z, Pappo J.	Infect Immun	10.1128/iai.61.6.2309-2315.1993	1993
	The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice.	Ferrero RL, Thiberge JM, Kansau I, Wuscher N, Huerre M, Labigne A.	Proc Natl Acad Sci U S A	10.1073/pnas.92.14.6499	1995
	Antagonistic activity against Helicobacter infection in vitro and in vivo by the human Lactobacillus acidophilus strain LB.	Coconnier MH, Lievin V, Hemery E, Servin AL.	Appl Environ Microbiol	10.1128/aem.64.11.4573-4580.1998	1998
	Catalase, a novel antigen for Helicobacter pylori vaccination.	Radcliff FJ, Hazell SL, Kolesnikow T, Doidge C, Lee A.	Infect Immun	10.1128/iai.65.11.4668-4674.1997	1997
	The spatial orientation of Helicobacter pylori in the gastric mucus.	Schreiber S, Konradt M, Groll C, Scheid P, Hanauer G, Werling HO, Josenhans C, Suerbaum S.	Proc Natl Acad Sci U S A	10.1073/pnas.0308386101	2004
Phylogeny	The aquatic budding bacterium Blastobacter denitrificans is a nitrogen-fixing symbiont of Aeschynomene indica.	van Berkum P, Eardly BD.	Appl Environ Microbiol	10.1128/aem.68.3.1132-1136.2002	2002
Genetics	Genome sequencing reveals a phage in Helicobacter pylori.	Lehours P, Vale FF, Bjursell MK, Melefors O, Advani R, Glavas S, Guegueniat J, Gontier E, Lacomme S, Alves Matos A, Menard A, Megraud F, Engstrand L, Andersson AF.	mBio	10.1128/mbio.00239-11	2011
	Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis.	Daughtry KD, Huang H, Malashkevich V, Patskovsky Y, Liu W, Ramagopal U, Sauder JM, Burley SK, Almo SC, Dunaway-Mariano D, Allen KN.	Biochemistry	10.1021/bi400659k	2013
	NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.	Pan Q, Kravchenko V, Katz A, Huang S, Ii M, Mathison JC, Kobayashi K, Flavell RA, Schreiber RD, Goeddel D, Ulevitch RJ.	Infect Immun	10.1128/iai.74.4.2121-2127.2006	2006
Metabolism	Evasion of Toll-like receptor 5 by flagellated bacteria.	Andersen-Nissen E, Smith KD, Strobe KL, Barrett SL, Cookson BT, Logan SM, Aderem A.	Proc Natl Acad Sci U S A	10.1073/pnas.0502040102	2005
Enzymology	Differentiation of Helicobacter pylori strains directly from gastric biopsy specimens by PCR-based restriction fragment length polymorphism analysis without culture.	Li C, Ha T, Chi DS, Ferguson DA, Jiang C, Laffan JJ, Thomas E.	J Clin Microbiol	10.1128/jcm.35.12.3021-3025.1997	1997
Metabolism	Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma.	Mueller A, O'Rourke J, Grimm J, Guillemin K, Dixon MF, Lee A, Falkow S.	Proc Natl Acad Sci U S A	10.1073/pnas.242741699	2003
	Compilation of small ribosomal subunit RNA structures.	Neefs JM, Van de Peer Y, De Rijk P, Chapelle S, De Wachter R.	Nucleic Acids Res	10.1093/nar/21.13.3025	1993
Metabolism	Glycoconjugate binding of gastric and enterohepatic Helicobacter spp.	Hynes SO, Teneberg S, Roche N, Wadstrom T.	Infect Immun	10.1128/iai.71.5.2976-2980.2003	2003
Phylogeny	Rapid identification and quantification of Campylobacter coli and Campylobacter jejuni by real-time PCR in pure cultures and in complex samples.	Leblanc-Maridor M, Beaudeau F, Seegers H, Denis M, Belloc C.	BMC Microbiol	10.1186/1471-2180-11-113	2011
	Serological discrimination of dogs infected with gastric Helicobacter spp. and uninfected dogs.	Strauss-Ayali D, Simpson KW, Schein AH, McDonough PL, Jacobson RH, Valentine BA, Peacock J	J Clin Microbiol	10.1128/JCM.37.5.1280-1287.1999	1999
Genetics	Immunological and molecular characterization of Helicobacter felis urease.	Gootz TD, Perez-Perez GI, Clancy J, Martin BA, Tait-Kamradt A, Blaser MJ	Infect Immun	10.1128/iai.62.3.793-798.1994	1994
Metabolism	Laboratory appraisal of optimal gaseous conditions for growth of zoonotic Helicobacter felis ATCC 49179.	Shiohara M, Kawakubo M, Matsumoto T, Kumagai T, Yamauchi K, Oana K, Ota H, Kawakami Y	Microbiol Immunol	10.1111/j.1348-0421.2009.00117.x	2009
Phylogeny	The inflammatory response in the mouse stomach to Helicobacter bizzozeronii, Helicobacter salomonis and two Helicobacter felis Strains.	De Bock M, Decostere A, Van den Bulck K, Baele M, Duchateau L, Haesebrouck F, Ducatelle R	J Comp Pathol	10.1016/j.jcpa.2005.01.007	2005
Metabolism	Helicobacter felis infection is associated with lymphoid follicular hyperplasia and mild gastritis but normal gastric secretory function in cats.	Simpson KW, Strauss-Ayali D, Scanziani E, Straubinger RK, McDonough PL, Straubinger AF, Chang YF, Domeneghini C, Arebi N, Calam J	Infect Immun	10.1128/IAI.68.2.779-790.2000	2000
Metabolism	Helicobacter felis infection in dogs: effect on gastric structure and function.	Simpson KW, McDonough PL, Strauss-Ayali D, Chang YF, Harpending P, Valentine BA	Vet Pathol	10.1354/vp.36-3-237	1999
	Helicobacter zhangjianzhongii sp. nov., isolated from dog feces.	Wang H, Gu Y, Zhou G, Chen X, Zhang X, Shao Z, Zhang M.	Front Genet	10.3389/fgene.2023.1240581	2023
Phylogeny	Helicobacter mesocricetorum sp. nov., A novel Helicobacter isolated from the feces of Syrian hamsters.	Simmons JH, Riley LK, Besch-Williford CL, Franklin CL.	J Clin Microbiol	10.1128/jcm.38.5.1811-1817.2000	2000
Phylogeny	Phylogeny of Helicobacter felis sp. nov., Helicobacter mustelae, and related bacteria.	Paster BJ, Lee A, Fox JG, Dewhirst FE, Tordoff LA, Fraser GJ, O'Rourke JL, Taylor NS, Ferrero R	Int J Syst Bacteriol	10.1099/00207713-41-1-31	1991

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#39710	Collection of Institut Pasteur ; Curators of the CIP; CIP 104084
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Helicobacter felis (CIP 104084, ATCC 49179, CCUG 28539)

Name and taxonomic classification

Morphology

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Physiology and metabolism

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