Lactobacillus helveticus (CIP 104345, ATCC 10386, NCDO 261)

Name: Lactobacillus helveticus (CIP 104345, ATCC 10386, NCDO 261)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 136298

Type strain

Strain Designation H2

Culture col. no. CIP 104345 ATCC 10386 NCDO 261 NCIMB 8024 H2

NCBI tax ID(s) 1587

Special Collections CIP

Links

Lactobacillus helveticus H2 is a facultative anaerobe, mesophilic, Gram-positive prokaryote of the family Lactobacillaceae.

Gram-positive rod-shaped facultative anaerobe mesophilic genome sequence

Name and taxonomic classification

SI-ID 35235

ATCC 10386,NCDO 261,CIP 104345,NCIB 8024,NCIMB 700261,NCIMB 8024,BCRC 12258,CCRC 12258

@ref 20215

Last LPSN update 2025-12-16 10:02:32

Domain Bacillati

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Lactobacillaceae

Genus Lactobacillus

Species Lactobacillus helveticus

Full scientific name Lactobacillus helveticus (Orla-Jensen 1919) Bergey et al. 1925 (Approved Lists 1980)

Synonyms (2)

Lactobacillus suntoryeus
"Thermobacterium helveticum"

BacDive ID	Other strains from **Lactobacillus helveticus** (23)	Type strain
6471	L. helveticus 12, Lh12, DSM 20075, ATCC 15009, CCUG 30139, ... (type strain)
6525	L. helveticus CBP1, DSM 3748
134852	L. helveticus CIP 76.19, ATCC 521, JCM 1003, NCDO 87, NCIMB ...
136299	L. helveticus J2, CIP 104346
136381	L. helveticus 5, CIP 53.165, ATCC 7995, JCM 11039
137106	L. helveticus H-80, CIP 57.15, ATCC 12046, JCM 1554, NCDO ...
137173	L. helveticus J5, CIP 104343, ATCC 10812, IFO 3809, NCDO ...
139090	L. helveticus B2, CIP 104344, NCDO 99, JCM 1004, LMG 11446, ...
139247	L. helveticus CIP 104436, ATCC 7993
153568	L. helveticus CCUG 50205, NCIMB 14005, JCM 30912, BCRC ...
154986	L. helveticus CCUG 55959
160849	L. helveticus JCM 1005, ATCC 8001, CECT 404, NCFB 103, ...
160853	L. helveticus JCM 1006, LMG 18174
160862	L. helveticus JCM 1007, ATCC 10797, LMG 11474
160865	L. helveticus JCM 1008, ATCC 8018, CECT 414, LMG 11449, ...
161004	L. helveticus JCM 1062, BCRC 14035, LMG 18182
161122	L. helveticus JCM 1103, LMG 18183
162696	L. helveticus JCM 20023, ATU L-21, IAM 1042
162913	L. helveticus JCM 20397, IAM 12090
172918	L. helveticus 61 BZ, CRBIP24.47
172919	L. helveticus 60 A, CRBIP24.54
172920	L. helveticus 60 B, CRBIP24.55
172921	L. helveticus 64 AB, CRBIP24.65

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
125438			93.5
125438	positive		93.805
35660	positive	rod-shaped

Culture and growth conditions

Culture medium

@ref	Name	Growth	Composition	Medium link
35660	MEDIUM 41- for Lactobacillus, Leuconostoc, Weissella, Pediococcus, Sporolactobacillus inulinus		Distilled water make up to (1000.000 ml);Man Rogosa Sharp broth (55.000 g)
35660	CIP Medium 41			Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
35660	positive	growth	37	mesophilic
35660	positive	growth	22-45
35660	negative	growth	10
35660	negative	growth	15

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
35660	facultative anaerobe
125439	obligate aerobe	95.4

Spore formation

@ref	Spore formation	Confidence
125438		90.442

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	-	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	-	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	-	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	+	builds acid from	from API 50CH acid
35660	17632 ChEBI	nitrate	-	reduction
35660	17632 ChEBI	nitrate	+	respiration
35660	16301 ChEBI	nitrite	-	reduction
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	-	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	+	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test
35660	15688 ChEBI	acetoin	-

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
35660	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68382	beta-galactosidase	+	3.2.1.23	from API zym
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
35660	catalase	-	1.11.1.6
68382	cystine arylamidase	+	3.4.11.3	from API zym
68382	esterase (C 4)	-		from API zym
68382	esterase lipase (C 8)	-		from API zym
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
35660	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
35660	ornithine decarboxylase	-	4.1.1.17
35660	oxidase	-
68382	trypsin	-	3.4.21.4	from API zym
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
35660	-	-	-	-	-	+	-	+	-	-	+	+	-	+	-	+	-	-	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
35660	not determinedn.d.	-	-	-	-	-	-	-	-	-	-	+	-	+	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
35660	1	Risk group (French classification)

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM76546v1 assembly for Lactobacillus helveticus ATCC 10386	contig	GCA_000765465	1587.20	2627853918	1587	14.3

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Lactobacillus helveticus ATCC 10386
NCBI: GCA_000765465

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	62.50	no
125439	motility	BacteriaNetⓘ	yes	53.40	no
125439	gram_stain	BacteriaNetⓘ	positive	73.40	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	95.40	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Lactobacillus helveticus ATCC 10386
PATRIC: 1587.20

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	93.81	no
125438	anaerobic	anaerobicⓘ	no	73.57	yes
125438	spore-forming	spore-formingⓘ	no	90.44	no
125438	thermophilic	thermophileⓘ	no	96.00	yes
125438	aerobic	aerobicⓘ	no	96.57	yes
125438	flagellated	motile2+ⓘ	no	93.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	Genomic Comparison of Lactobacillus helveticus Strains Highlights Probiotic Potential.	Fontana A, Falasconi I, Molinari P, Treu L, Basile A, Vezzi A, Campanaro S, Morelli L.	Front Microbiol	10.3389/fmicb.2019.01380	2019
Pathogenicity	Neoteric Biofilms Applied to Enhance the Safety Characteristics of Ras Cheese during Ripening.	Ibrahim RA, Abd El-Salam BA, Alsulami T, Ali HS, Hoppe K, Badr AN.	Foods	10.3390/foods12193548	2023
	Molecular diversity within Lactobacillus helveticus as revealed by genotypic characterization.	Giraffa G, Gatti M, Rossetti L, Senini L, Neviani E.	Appl Environ Microbiol	10.1128/aem.66.4.1259-1265.2000	2000
Enzymology	Genetic characterization of a cell envelope-associated proteinase from Lactobacillus helveticus CNRZ32.	Pederson JA, Mileski GJ, Weimer BC, Steele JL.	J Bacteriol	10.1128/jb.181.15.4592-4597.1999	1999
Metabolism	Deamination of deoxycytidine and 5-methyldeoxycytidine in developing anthers of Lilium longiflorum (var. Croft).	HOTTA Y, STERN H.	J Biophys Biochem Cytol	10.1083/jcb.9.2.279	1961
Metabolism	Reciprocal replacement of oleic acid and CO2 in the nutrition of the minute streptococci and Lactobacillus leichmannii.	DEIBEL RH, NIVEN CF.	J Bacteriol	10.1128/jb.70.2.134-140.1955	1955
	A Lactobacillus helveticus-Specific DNA Probe Detects Restriction Fragment Length Polymorphisms in This Species.	de Los Reyes-Gavilan CG, Limsowtin GK, Tailliez P, Sechaud L, Accolas JP.	Appl Environ Microbiol	10.1128/aem.58.10.3429-3432.1992	1992
	Comparative Study of 35 Bacteriophages of Lactobacillus helveticus: Morphology and Host Range.	Sechaud L, Rousseau M, Fayard B, Callegari ML, Quenee P, Accolas JP.	Appl Environ Microbiol	10.1128/aem.58.3.1011-1018.1992	1992
	Survey on the phage resistance mechanisms displayed by a dairy Lactobacillus helveticus strain.	Zago M, Orru L, Rossetti L, Lamontanara A, Fornasari ME, Bonvini B, Meucci A, Carminati D, Cattivelli L, Giraffa G	Food Microbiol	10.1016/j.fm.2017.04.014	2017

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#35660	Collection of Institut Pasteur ; Curators of the CIP; CIP 104345
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#68371	Automatically annotated from API 50CH acid .
#68382	Automatically annotated from API zym .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Lactobacillus helveticus (CIP 104345, ATCC 10386, NCDO 261)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

Metabolite tests

Enzymes

API zym

API 50CHac

Isolation, sampling and environmental information

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_000765465

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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