Mycobacterium avium subsp. paratuberculosis (CIP 103968, ATCC 49164)

Name: Mycobacterium avium subsp. paratuberculosis (CIP 103968, ATCC 49164)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 135351

Type strain

Culture col. no. CIP 103968 ATCC 49164

NCBI tax ID(s) 1770

Special Collections CIP

History CIP <- 1994, ATCC <- R.J. Chiodini: strain Holland-1, Mycobacterium paratuberculosis <- J. Haagsma

Links

Mycobacterium avium subsp. paratuberculosis CIP 103968 is a rod-shaped bacterium of the family Mycobacteriaceae.

rod-shaped Bacteria

Name and taxonomic classification

SI-ID 42332

ATCC 49164,CIP 103968

@ref 20215

Last LPSN update 2026-05-29 08:38:32

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Mycobacteriales

Family Mycobacteriaceae

Genus Mycobacterium

Species Mycobacterium avium subsp. paratuberculosis

Full scientific name Mycobacterium avium subsp. paratuberculosis (Bergey et al. 1923) Thorel et al. 1990

Synonyms (1)

Mycobacterium paratuberculosis

BacDive ID	Other strains from **Mycobacterium avium subsp. paratuberculosis** (9)	Type strain
8439	M. avium subsp. paratuberculosis DSM 44133, ATCC 19698, TMC 807, CCUG 55483, ... (type strain)
8440	M. avium subsp. paratuberculosis 1351, DSM 44135
135349	M. avium subsp. paratuberculosis JC31, CIP 103964, ATCC 19851, NCTC 8578
135350	M. avium subsp. paratuberculosis CIP 103967, ATCC 43545
135352	M. avium subsp. paratuberculosis 1001, CIP 103971
136665	M. avium subsp. paratuberculosis TB795/95, CIP 107488
136893	M. avium subsp. paratuberculosis CIP 103965, ATCC 43015
137548	M. avium subsp. paratuberculosis 4138, CIP 103978
169420	M. avium subsp. paratuberculosis JIII-386, DSM 108962

Morphology

Cell morphology

@ref	Cell shape	Motility
34447	rod-shaped

Culture and growth conditions

Culture medium

@ref	Name	Growth	Composition	Medium link
34447	MEDIUM 96 - for Mycobacterium avium subsp. paratuberculosis		Tween 80 (0.500 ml);Middlebrook 7H9 broth (4.700 g);Middelbrook OADC enrichment (100.000 ml);Distilled water (900.000 ml);Mycobactine (2.000 ml)
34447	CIP Medium 96			Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
34447	positive	growth	37
34447	positive	growth	30-37
34447	negative	growth	10
34447	negative	growth	22
34447	negative	growth	45

Physiology and metabolism

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
34447	606565 ChEBI	hippurate	-	hydrolysis
34447	17632 ChEBI	nitrate	-	reduction
34447	16301 ChEBI	nitrite	-	reduction

Metabolite production

@ref	Chebi-ID	Metabolite	Production
34447	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	-	3.1.3.2	from API zym
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68382	beta-galactosidase	-	3.2.1.23	from API zym
34447	beta-galactosidase	-	3.2.1.23
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
34447	catalase	+	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
34447	gamma-glutamyltransferase	+	2.3.2.2
34447	gelatinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
34447	oxidase	-
68382	trypsin	-	3.4.21.4	from API zym
34447	urease	-	3.5.1.5
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
34447	-	-	+	+	-	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation

@ref	Sample type	Host species	Country	Country ISO 3 Code	Continent	Isolation date
34447			Netherlands	NLD	Europe
34447	Human, With Crohn's disease, intestine	Homo sapiens	Netherlands	NLD	Europe	1987

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
34447	2	Risk group (French classification)

Sequence information

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	A novel real-time PCR assay for specific detection and quantification of Mycobacterium avium subsp. paratuberculosis in milk with the inherent possibility of differentiation between viable and dead cells.	Dzieciol M, Volgger P, Khol J, Baumgartner W, Wagner M, Hein I.	BMC Res Notes	10.1186/1756-0500-3-251	2010
Phylogeny	Efficient differentiation of Mycobacterium avium complex species and subspecies by use of five-target multiplex PCR.	Shin SJ, Lee BS, Koh WJ, Manning EJ, Anklam K, Sreevatsan S, Lambrecht RS, Collins MT.	J Clin Microbiol	10.1128/jcm.00904-10	2010
Enzymology	New PCR systems to confirm real-time PCR detection of Mycobacterium avium subsp. paratuberculosis.	Herthnek D, Bolske G.	BMC Microbiol	10.1186/1471-2180-6-87	2006
Phylogeny	Mycobacterium avium subsp. paratuberculosis strains isolated from Crohn's disease patients and animal species exhibit similar polymorphic locus patterns.	Ghadiali AH, Strother M, Naser SA, Manning EJ, Sreevatsan S.	J Clin Microbiol	10.1128/jcm.42.11.5345-5348.2004	2004
Phylogeny	Amplified fragment length polymorphism reveals specific epigenetic distinctions between Mycobacterium avium subspecies paratuberculosis isolates of various isolation types.	O'Shea B, Khare S, Klein P, Roussel A, Adams LG, Ficht TA, Rice-Ficht AC.	J Clin Microbiol	10.1128/jcm.01123-10	2011
	Comparative genomic analysis of Mycobacterium avium subspecies obtained from multiple host species.	Paustian ML, Zhu X, Sreevatsan S, Robbe-Austerman S, Kapur V, Bannantine JP.	BMC Genomics	10.1186/1471-2164-9-135	2008

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#34447	Collection of Institut Pasteur ; Curators of the CIP; CIP 103968
#68382	Automatically annotated from API zym .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Mycobacterium avium subsp. paratuberculosis (CIP 103968, ATCC 49164)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Metabolite utilization

Metabolite production

Enzymes

API zym

Isolation, sampling and environmental information

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome-based predictions

Literature

Literature

References

BacDive

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