Mycobacterium avium subsp. paratuberculosis (CIP 103967, ATCC 43545)

Name: Mycobacterium avium subsp. paratuberculosis (CIP 103967, ATCC 43545)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 135350

Type strain

Culture col. no. CIP 103967 ATCC 43545

NCBI tax ID(s) 1770

Special Collections CIP

History CIP <- 1994, ATCC <- R.J. Chiodini: strain Dominic, Mycobacterium paratuberculosis

Links

Mycobacterium avium subsp. paratuberculosis CIP 103967 is a Gram-positive, rod-shaped bacterium that was isolated from Human, With Crohn's disease, intestinal tissue.

Gram-positive rod-shaped Bacteria

Name and taxonomic classification

SI-ID 46842

ATCC 43545,CIP 103967

@ref 20215

Last LPSN update 2026-05-29 08:38:32

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Mycobacteriales

Family Mycobacteriaceae

Genus Mycobacterium

Species Mycobacterium avium subsp. paratuberculosis

Full scientific name Mycobacterium avium subsp. paratuberculosis (Bergey et al. 1923) Thorel et al. 1990

Synonyms (1)

Mycobacterium paratuberculosis

BacDive ID	Other strains from **Mycobacterium avium subsp. paratuberculosis** (9)	Type strain
8439	M. avium subsp. paratuberculosis DSM 44133, ATCC 19698, TMC 807, CCUG 55483, ... (type strain)
8440	M. avium subsp. paratuberculosis 1351, DSM 44135
135349	M. avium subsp. paratuberculosis JC31, CIP 103964, ATCC 19851, NCTC 8578
135351	M. avium subsp. paratuberculosis CIP 103968, ATCC 49164
135352	M. avium subsp. paratuberculosis 1001, CIP 103971
136665	M. avium subsp. paratuberculosis TB795/95, CIP 107488
136893	M. avium subsp. paratuberculosis CIP 103965, ATCC 43015
137548	M. avium subsp. paratuberculosis 4138, CIP 103978
169420	M. avium subsp. paratuberculosis JIII-386, DSM 108962

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
34446	positive	rod-shaped

Culture and growth conditions

Culture medium

@ref	Name	Composition	Medium link
34446	MEDIUM 72- for trypto casein soja agar	Distilled water make up to (1000.000 ml);Trypto casein soy agar (40.000 g)
34446	CIP Medium 750		Medium recipe at CIP
34446	CIP Medium 96		Medium recipe at CIP
34446	CIP Medium 72		Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
34446	positive	growth	37

Physiology and metabolism

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
34446	606565 ChEBI	hippurate	-	hydrolysis

Metabolite production

@ref	Chebi-ID	Metabolite	Production
34446	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68382	beta-galactosidase	-	3.2.1.23	from API zym
34446	beta-galactosidase	-	3.2.1.23
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
34446	catalase	+	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
34446	gamma-glutamyltransferase	-	2.3.2.2
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	-		from API zym
34446	oxidase	-
68382	trypsin	-	3.4.21.4	from API zym
34446	urease	-	3.5.1.5
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
34446	-	+	+	+	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation

@ref	Sample type	Host species	Isolation date
34446	Human, With Crohn's disease, intestinal tissue	Homo sapiens	1984

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
34446	2	Risk group (French classification)

Sequence information

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Discovery of Mycobacterium avium subsp. paratuberculosis Lytic Phages with Extensive Host Range Across Rapid- and Slow-Growing Pathogenic Mycobacterial Species.	Golla AC, Chaumontet J, Vande Voorde R, Danelishvili L.	Antibiotics (Basel)	10.3390/antibiotics13111009	2024
	A novel real-time PCR assay for specific detection and quantification of Mycobacterium avium subsp. paratuberculosis in milk with the inherent possibility of differentiation between viable and dead cells.	Dzieciol M, Volgger P, Khol J, Baumgartner W, Wagner M, Hein I.	BMC Res Notes	10.1186/1756-0500-3-251	2010
	Comparison of a mycobacterial phage assay to detect viable Mycobacterium avium subspecies paratuberculosis with standard diagnostic modalities in cattle with naturally infected Johne disease.	Greenstein RJ, Su L, Grant IR, Foddai ACG, Turner A, Nagati JS, Brown ST, Stabel JR.	Gut Pathog	10.1186/s13099-021-00425-5	2021
Phylogeny	Efficient differentiation of Mycobacterium avium complex species and subspecies by use of five-target multiplex PCR.	Shin SJ, Lee BS, Koh WJ, Manning EJ, Anklam K, Sreevatsan S, Lambrecht RS, Collins MT.	J Clin Microbiol	10.1128/jcm.00904-10	2010
	NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease.	Glubb DM, Gearry RB, Barclay ML, Roberts RL, Pearson J, Keenan JI, McKenzie J, Bentley RW.	World J Gastroenterol	10.3748/wjg.v17.i23.2829	2011
Pathogenicity	Vitamins A & D inhibit the growth of mycobacteria in radiometric culture.	Greenstein RJ, Su L, Brown ST.	PLoS One	10.1371/journal.pone.0029631	2012
Metabolism	Uptake and persistence of Mycobacterium avium subsp. paratuberculosis in human monocytes.	Keown DA, Collings DA, Keenan JI.	Infect Immun	10.1128/iai.00534-12	2012
Phylogeny	Mycobacterium avium subsp. paratuberculosis strains isolated from Crohn's disease patients and animal species exhibit similar polymorphic locus patterns.	Ghadiali AH, Strother M, Naser SA, Manning EJ, Sreevatsan S.	J Clin Microbiol	10.1128/jcm.42.11.5345-5348.2004	2004
	Monensin causes dose dependent inhibition of Mycobacterium avium subspecies paratuberculosis in radiometric culture.	Greenstein RJ, Su L, Whitlock RH, Brown ST.	Gut Pathog	10.1186/1757-4749-1-4	2009
Phylogeny	Amplified fragment length polymorphism reveals specific epigenetic distinctions between Mycobacterium avium subspecies paratuberculosis isolates of various isolation types.	O'Shea B, Khare S, Klein P, Roussel A, Adams LG, Ficht TA, Rice-Ficht AC.	J Clin Microbiol	10.1128/jcm.01123-10	2011
Pathogenicity	On the action of cyclosporine A, rapamycin and tacrolimus on M. avium including subspecies paratuberculosis.	Greenstein RJ, Su L, Juste RA, Brown ST.	PLoS One	10.1371/journal.pone.0002496	2008
Pathogenicity	The thioamides methimazole and thiourea inhibit growth of M. avium Subspecies paratuberculosis in culture.	Greenstein RJ, Su L, Brown ST.	PLoS One	10.1371/journal.pone.0011099	2010
	Comparative genomic analysis of Mycobacterium avium subspecies obtained from multiple host species.	Paustian ML, Zhu X, Sreevatsan S, Robbe-Austerman S, Kapur V, Bannantine JP.	BMC Genomics	10.1186/1471-2164-9-135	2008
Phylogeny	Identification of mycobacteria by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry.	Pignone M, Greth KM, Cooper J, Emerson D, Tang J.	J Clin Microbiol	10.1128/jcm.01959-05	2006
	On the etiology of Crohn disease.	Mishina D, Katsel P, Brown ST, Gilberts EC, Greenstein RJ.	Proc Natl Acad Sci U S A	10.1073/pnas.93.18.9816	1996

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#34446	Collection of Institut Pasteur ; Curators of the CIP; CIP 103967
#68382	Automatically annotated from API zym .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Mycobacterium avium subsp. paratuberculosis (CIP 103967, ATCC 43545)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Metabolite utilization

Metabolite production

Enzymes

API zym

Isolation, sampling and environmental information

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome-based predictions

Literature

Literature

References

BacDive

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