Clostridioides difficile CD196 is an anaerobe, spore-forming, mesophilic prokaryote of the family Peptostreptococcaceae.
spore-forming Gram-positive rod-shaped anaerobe mesophilic genome sequence| @ref 20215 |
Last LPSN update
2025-12-16 10:02:07 |
| Domain Bacillati |
| Phylum Bacillota |
| Class Clostridia |
| Order Peptostreptococcales |
| Family Peptostreptococcaceae |
| Genus Clostridioides |
| Species Clostridioides difficile |
| Full scientific name Clostridioides difficile (Hall and O'Toole 1935) Lawson et al. 2016 |
| Synonyms (3) |
| 33182 | Spore formationyes |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 33182 | 17057 ChEBI | cellobiose | - | degradation | |
| 33182 | 17108 ChEBI | D-arabinose | - | degradation | |
| 33182 | 15824 ChEBI | D-fructose | + | degradation | |
| 33182 | 17634 ChEBI | D-glucose | + | degradation | |
| 33182 | 65327 ChEBI | D-xylose | - | degradation | |
| 33182 | 4853 ChEBI | esculin | + | hydrolysis | |
| 33182 | 17716 ChEBI | lactose | - | degradation | |
| 33182 | 17306 ChEBI | maltose | - | degradation | |
| 33182 | 17632 ChEBI | nitrate | - | reduction | |
| 33182 | 17632 ChEBI | nitrate | + | respiration | |
| 33182 | 16301 ChEBI | nitrite | - | reduction | |
| 33182 | 17814 ChEBI | salicin | - | degradation | |
| 33182 | 17992 ChEBI | sucrose | - | degradation |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | - | 3.1.3.2 | from API zym |
| 68382 | alkaline phosphatase | - | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | - | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 33182 | amylase | - | ||
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 33182 | beta-galactosidase | + | 3.2.1.23 | |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 33182 | caseinase | - | 3.4.21.50 | |
| 33182 | catalase | - | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 33182 | DNase | - | ||
| 68382 | esterase (C 4) | - | from API zym | |
| 68382 | esterase lipase (C 8) | - | from API zym | |
| 33182 | gelatinase | - | ||
| 33182 | lecithinase | - | ||
| 68382 | leucine arylamidase | - | 3.4.11.1 | from API zym |
| 33182 | lipase | - | ||
| 68382 | lipase (C 14) | - | from API zym | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | - | from API zym | |
| 33182 | oxidase | - | ||
| 33182 | protease | - | ||
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 33182 | tween esterase | - | ||
| 33182 | urease | - | 3.5.1.5 | |
| 68382 | valine arylamidase | - | from API zym |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 66792 | ASM8522v1 assembly for Clostridioides difficile CD196 | complete | GCA_000085225   | 645462.3  | 646311914  | 645462 | 99.02 | |
| 66792 | ASM2137841v1 assembly for Clostridioides difficile CD196 | complete | GCA_021378415 | 645462.89 | 8005870720 | 645462 | 98.97 | |
| 66792 | cdeaa assembly for Clostridioides difficile CIP 107932 | chromosome | GCA_000155045 | 499176.4 | 642791606 | 499176 | 76.2 | |
| 66792 | ASM44960v2 assembly for Clostridioides difficile CD196 | contig | GCA_000449605 | 645462.16 | 2541047488 | 645462 | |
| Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|
| Recognition of extracellular DNA by type IV pili promotes biofilm formation by Clostridioides difficile. | Ronish LA, Sidner B, Yu Y, Piepenbrink KH. | J Biol Chem | 10.1016/j.jbc.2022.102449 | 2022 | |
| Cwl0971, a novel peptidoglycan hydrolase, plays pleiotropic roles in Clostridioides difficile R20291. | Zhu D, Patabendige HMLW, Tomlinson BR, Wang S, Hussain S, Flores D, He Y, Shaw LN, Sun X. | Environ Microbiol | 10.1111/1462-2920.15529 | 2021 | |
| Cwp22, a novel peptidoglycan cross-linking enzyme, plays pleiotropic roles in Clostridioides difficile. | Zhu D, Zhu D, Bullock J, He Y, Sun X. | Environ Microbiol | 10.1111/1462-2920.14706 | 2019 | |
| Motility and flagellar glycosylation in Clostridium difficile. | Twine SM, Reid CW, Aubry A, McMullin DR, Fulton KM, Austin J, Logan SM. | J Bacteriol | 10.1128/jb.00861-09 | 2009 | |
| The First Two Clostridium difficile Ribotype 027/ST1 Isolates Identified in Beijing, China-an Emerging Problem or a Neglected Threat? | Cheng JW, Xiao M, Kudinha T, Xu ZP, Hou X, Sun LY, Zhang L, Fan X, Kong F, Xu YC. | Sci Rep | 10.1038/srep18834 | 2016 | |
| Analysis of ultra low genome conservation in Clostridium difficile. | Scaria J, Ponnala L, Janvilisri T, Yan W, Mueller LA, Chang YF. | PLoS One | 10.1371/journal.pone.0015147 | 2010 | |
| Structure of Clostridium difficile PilJ exhibits unprecedented divergence from known type IV pilins. | Piepenbrink KH, Maldarelli GA, de la Pena CF, Mulvey GL, Snyder GA, De Masi L, von Rosenvinge EC, Gunther S, Armstrong GD, Donnenberg MS, Sundberg EJ. | J Biol Chem | 10.1074/jbc.m113.534404 | 2014 | |
| Clostridium difficile is an autotrophic bacterial pathogen. | Kopke M, Straub M, Durre P. | PLoS One | 10.1371/journal.pone.0062157 | 2013 | |
| Fourteen-genome comparison identifies DNA markers for severe-disease-associated strains of Clostridium difficile. | Forgetta V, Oughton MT, Marquis P, Brukner I, Blanchette R, Haub K, Magrini V, Mardis ER, Gerding DN, Loo VG, Miller MA, Mulvey MR, Rupnik M, Dascal A, Dewar K. | J Clin Microbiol | 10.1128/jcm.00391-11 | 2011 | |
| Sequence similarity of Clostridium difficile strains by analysis of conserved genes and genome content is reflected by their ribotype affiliation. | Kurka H, Ehrenreich A, Ludwig W, Monot M, Rupnik M, Barbut F, Indra A, Dupuy B, Liebl W. | PLoS One | 10.1371/journal.pone.0086535 | 2014 | |
| Clostridioides difficile strain-dependent and strain-independent adaptations to a microaerobic environment. | Weiss A, Lopez CA, Beavers WN, Rodriguez J, Skaar EP | Microb Genom | 10.1099/mgen.0.000738 | 2021 | |
| Analysis of metabolic evolution in bacteria using whole-genome metabolic models. | Bryant WA, Faruqi AA, Pinney JW | J Comput Biol | 10.1089/cmb.2013.0079 | 2013 | |
| Fidaxomicin inhibits toxin production in Clostridium difficile. | Babakhani F, Bouillaut L, Sears P, Sims C, Gomez A, Sonenshein AL | J Antimicrob Chemother | 10.1093/jac/dks450 | 2012 | |
| Secretome analysis of Clostridium difficile strains. | Boetzkes A, Felkel KW, Zeiser J, Jochim N, Just I, Pich A | Arch Microbiol | 10.1007/s00203-012-0802-5 | 2012 | |
| Assessing the role of p-cresol tolerance in Clostridium difficile. | Dawson LF, Stabler RA, Wren BW | J Med Microbiol | 10.1099/jmm.0.47744-0 | 2008 | |
| ADP-ribosylating binary toxin genes of Clostridium difficile strain CCUG 20309. | Chang SY, Song KP | DNA Seq | 10.3109/10425170109047564 | 2001 | |
| Production of a complete binary toxin (actin-specific ADP-ribosyltransferase) by Clostridium difficile CD196. | Perelle S, Gibert M, Bourlioux P, Corthier G, Popoff MR | Infect Immun | 10.1128/iai.65.4.1402-1407.1997 | 1997 | |
| Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain. | Popoff MR, Rubin EJ, Gill DM, Boquet P | Infect Immun | 10.1128/iai.56.9.2299-2306.1988 | 1988 | |
| A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile. | Thanissery R, Zeng D, Doyle RG, Theriot CM | Front Microbiol | 10.3389/fmicb.2018.01206 | 2018 | |
| Comparative genomic analysis of Clostridium difficile ribotype 027 strains including the newly sequenced strain NCKUH-21 isolated from a patient in Taiwan. | Suzuki H, Tomita M, Tsai PJ, Ko WC, Hung YP, Huang IH, Chen JW | Gut Pathog | 10.1186/s13099-017-0219-4 | 2017 | |
| Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids. | Thanissery R, Winston JA, Theriot CM | Anaerobe | 10.1016/j.anaerobe.2017.03.004 | 2017 | |
| Clostridium-DT(DB): a comprehensive database for potential drug targets of Clostridium difficile. | Jadhav A, Ezhilarasan V, Prakash Sharma O, Pan A | Comput Biol Med | 10.1016/j.compbiomed.2013.01.009 | 2013 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive134676.20251217.10
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BacDive in 2025: the core database for prokaryotic strain data
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