Saccharopolyspora erythraea (DSM 40517, AS 4.166, ATCC 11635)

Cell morphology

Multimedia

• @ref:	9612
  multimedia content:	DSM_40517-1.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40517-1.jpg
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

• @ref:	9612
  multimedia content:	DSM_40517.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40517.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9612	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water

Culture temp

Oxygen tolerance

Compound production

Halophily

Observation

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68369	17128 ChEBI	adipate	+	assimilation	from API 20NE
68368	27613 ChEBI	amygdalin	-	fermentation	from API 20E
18604	22599 ChEBI	arabinose	+
68369	29016 ChEBI	arginine	-	hydrolysis	from API 20NE
68368	29016 ChEBI	arginine	-	hydrolysis	from API 20E
18604	62968 ChEBI	cellulose	+
68369	17634 ChEBI	D-glucose	+	assimilation	from API 20NE
68369	17634 ChEBI	D-glucose	-	fermentation	from API 20NE
68368	17634 ChEBI	D-glucose	-	fermentation	from API 20E
68369	16899 ChEBI	D-mannitol	+	assimilation	from API 20NE
68368	16899 ChEBI	D-mannitol	-	fermentation	from API 20E
68369	16024 ChEBI	D-mannose	+	assimilation	from API 20NE
68369	27689 ChEBI	decanoate	-	assimilation	from API 20NE
68369	4853 ChEBI	esculin	+	hydrolysis	from API 20NE
18604	28757 ChEBI	fructose	+
68369	5291 ChEBI	gelatin	+	hydrolysis	from API 20NE
68369	24265 ChEBI	gluconate	+	assimilation	from API 20NE
18604	17234 ChEBI	glucose	+
68368	30849 ChEBI	L-arabinose	-	fermentation	from API 20E
68368	62345 ChEBI	L-rhamnose	-	fermentation	from API 20E
68368	25094 ChEBI	lysine	-	degradation	from API 20E
68369	25115 ChEBI	malate	+	assimilation	from API 20NE
68369	17306 ChEBI	maltose	+	assimilation	from API 20NE
18604	29864 ChEBI	mannitol	+
68368	28053 ChEBI	melibiose	-	fermentation	from API 20E
18604	17268 ChEBI	myo-inositol	+
68368	17268 ChEBI	myo-inositol	-	fermentation	from API 20E
68369	59640 ChEBI	N-acetylglucosamine	+	assimilation	from API 20NE
68369	17632 ChEBI	nitrate	-	reduction	from API 20NE
68368	17632 ChEBI	nitrate	-	reduction	from API 20E
68368	18257 ChEBI	ornithine	-	degradation	from API 20E
18604	16634 ChEBI	raffinose	+
18604	26546 ChEBI	rhamnose	+
68368	30911 ChEBI	sorbitol	-	fermentation	from API 20E
18604	17992 ChEBI	sucrose	+
68368	17992 ChEBI	sucrose	-	fermentation	from API 20E
68369	27897 ChEBI	tryptophan	-	energy source	from API 20NE
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68369	16199 ChEBI	urea	+	hydrolysis	from API 20NE
68368	16199 ChEBI	urea	+	hydrolysis	from API 20E
18604	18222 ChEBI	xylose	+

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	17997 ChEBI	dinitrogen		from API 20E
67770	42355 ChEBI	erythromycin A
67770	28196 ChEBI	erythromycin B
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68369	35581 ChEBI	indole		from API 20NE
68368	35581 ChEBI	indole		from API 20E
68368	16301 ChEBI	nitrite		from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68369	35581 ChEBI	indole	-	from API 20NE
68368	35581 ChEBI	indole	-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68369	arginine dihydrolase	-	3.5.3.6	from API 20NE
68368	arginine dihydrolase	-	3.5.3.6	from API 20E
68368	beta-galactosidase	-	3.2.1.23	from API 20E
68369	beta-glucosidase	+	3.2.1.21	from API 20NE
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68369	gelatinase	+		from API 20NE
68382	lipase (C 14)	-		from API zym
68368	lysine decarboxylase	-	4.1.1.18	from API 20E
68368	ornithine decarboxylase	-	4.1.1.17	from API 20E
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68369	urease	+	3.5.1.5	from API 20NE
68368	urease	+	3.5.1.5	from API 20E

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	butanoate fermentation	100	4 of 4
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	glycine betaine biosynthesis	100	5 of 5
66794	molybdenum cofactor biosynthesis	100	9 of 9
66794	formaldehyde oxidation	100	3 of 3
66794	chorismate metabolism	100	9 of 9
66794	coenzyme A metabolism	100	4 of 4
66794	palmitate biosynthesis	100	22 of 22
66794	adipate degradation	100	2 of 2
66794	Entner Doudoroff pathway	100	10 of 10
66794	3-chlorocatechol degradation	100	5 of 5
66794	acetate fermentation	100	4 of 4
66794	enterobactin biosynthesis	100	3 of 3
66794	teichoic acid biosynthesis	100	1 of 1
66794	propanol degradation	100	7 of 7
66794	vitamin K metabolism	100	5 of 5
66794	valine metabolism	100	9 of 9
66794	ketogluconate metabolism	100	8 of 8
66794	serine metabolism	100	9 of 9
66794	kanosamine biosynthesis II	100	2 of 2
66794	pentose phosphate pathway	100	11 of 11
66794	methylglyoxal degradation	100	5 of 5
66794	lipoate biosynthesis	100	5 of 5
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	reductive acetyl coenzyme A pathway	100	7 of 7
66794	ppGpp biosynthesis	100	4 of 4
66794	ribulose monophosphate pathway	100	2 of 2
66794	cardiolipin biosynthesis	100	7 of 7
66794	L-lactaldehyde degradation	100	3 of 3
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	aspartate and asparagine metabolism	100	9 of 9
66794	4-hydroxymandelate degradation	100	9 of 9
66794	taurine degradation	100	1 of 1
66794	suberin monomers biosynthesis	100	2 of 2
66794	biotin biosynthesis	100	4 of 4
66794	ceramide biosynthesis	100	1 of 1
66794	ethanol fermentation	100	2 of 2
66794	threonine metabolism	100	10 of 10
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	CO2 fixation in Crenarchaeota	100	9 of 9
66794	lactate fermentation	100	4 of 4
66794	glycogen metabolism	100	5 of 5
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	cellulose degradation	100	5 of 5
66794	folate polyglutamylation	100	1 of 1
66794	degradation of sugar acids	96	24 of 25
66794	citric acid cycle	92.86	13 of 14
66794	leucine metabolism	92.31	12 of 13
66794	phenylalanine metabolism	92.31	12 of 13
66794	proline metabolism	90.91	10 of 11
66794	myo-inositol biosynthesis	90	9 of 10
66794	4-hydroxyphenylacetate degradation	90	9 of 10
66794	propionate fermentation	90	9 of 10
66794	glutamate and glutamine metabolism	89.29	25 of 28
66794	NAD metabolism	88.89	16 of 18
66794	allantoin degradation	88.89	8 of 9
66794	vitamin B12 metabolism	88.24	30 of 34
66794	dTDPLrhamnose biosynthesis	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	purine metabolism	87.23	82 of 94
66794	flavin biosynthesis	86.67	13 of 15
66794	heme metabolism	85.71	12 of 14
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	glutathione metabolism	85.71	12 of 14
66794	pyrimidine metabolism	84.44	38 of 45
66794	tryptophan metabolism	84.21	32 of 38
66794	selenocysteine biosynthesis	83.33	5 of 6
66794	glycolate and glyoxylate degradation	83.33	5 of 6
66794	degradation of hexoses	83.33	15 of 18
66794	glycolysis	82.35	14 of 17
66794	degradation of pentoses	82.14	23 of 28
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	hydrogen production	80	4 of 5
66794	gallate degradation	80	4 of 5
66794	elloramycin biosynthesis	80	4 of 5
66794	starch degradation	80	8 of 10
66794	metabolism of amino sugars and derivatives	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	alanine metabolism	79.31	23 of 29
66794	arginine metabolism	79.17	19 of 24
66794	photosynthesis	78.57	11 of 14
66794	d-mannose degradation	77.78	7 of 9
66794	lipid metabolism	77.42	24 of 31
66794	vitamin B1 metabolism	76.92	10 of 13
66794	urea cycle	76.92	10 of 13
66794	methionine metabolism	76.92	20 of 26
66794	histidine metabolism	75.86	22 of 29
66794	degradation of sugar alcohols	75	12 of 16
66794	gluconeogenesis	75	6 of 8
66794	cyclohexanol degradation	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	sulfopterin metabolism	75	3 of 4
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	non-pathway related	73.68	28 of 38
66794	d-xylose degradation	72.73	8 of 11
66794	oxidative phosphorylation	72.53	66 of 91
66794	tetrahydrofolate metabolism	71.43	10 of 14
66794	tyrosine metabolism	71.43	10 of 14
66794	phenol degradation	70	14 of 20
66794	isoprenoid biosynthesis	69.23	18 of 26
66794	methane metabolism	66.67	2 of 3
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	cysteine metabolism	66.67	12 of 18
66794	lysine metabolism	66.67	28 of 42
66794	cyanate degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	nitrate assimilation	66.67	6 of 9
66794	IAA biosynthesis	66.67	2 of 3
66794	octane oxidation	66.67	2 of 3
66794	polyamine pathway	65.22	15 of 23
66794	cholesterol biosynthesis	63.64	7 of 11
66794	metabolism of disaccharids	63.64	7 of 11
66794	vitamin B6 metabolism	63.64	7 of 11
66794	C4 and CAM-carbon fixation	62.5	5 of 8
66794	carnitine metabolism	62.5	5 of 8
66794	sulfate reduction	61.54	8 of 13
66794	glycine metabolism	60	6 of 10
66794	coenzyme M biosynthesis	60	6 of 10
66794	D-cycloserine biosynthesis	60	3 of 5
66794	carotenoid biosynthesis	59.09	13 of 22
66794	aclacinomycin biosynthesis	57.14	4 of 7
66794	androgen and estrogen metabolism	56.25	9 of 16
66794	daunorubicin biosynthesis	55.56	5 of 9
66794	ascorbate metabolism	54.55	12 of 22
66794	phenylpropanoid biosynthesis	53.85	7 of 13
66794	phosphatidylethanolamine bioynthesis	53.85	7 of 13
66794	3-phenylpropionate degradation	53.33	8 of 15
66794	toluene degradation	50	2 of 4
66794	sphingosine metabolism	50	3 of 6
66794	chlorophyll metabolism	50	9 of 18
66794	resorcinol degradation	50	1 of 2
66794	phenylmercury acetate degradation	50	1 of 2
66794	pantothenate biosynthesis	50	3 of 6
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	quinate degradation	50	1 of 2
66794	vitamin E metabolism	50	2 of 4
66794	degradation of aromatic, nitrogen containing compounds	50	6 of 12
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	alginate biosynthesis	50	2 of 4
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	lipid A biosynthesis	44.44	4 of 9
66794	benzoyl-CoA degradation	42.86	3 of 7
66794	creatinine degradation	40	2 of 5
66794	bacilysin biosynthesis	40	2 of 5
66794	arachidonate biosynthesis	40	2 of 5
66794	methanogenesis from CO2	33.33	4 of 12
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	sulfoquinovose degradation	33.33	1 of 3
66794	arachidonic acid metabolism	27.78	5 of 18
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	catecholamine biosynthesis	25	1 of 4
66794	CMP-KDO biosynthesis	25	1 of 4

API 20E

API zym

API 20NE

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM6288v1 assembly for Saccharopolyspora erythraea NRRL 2338	complete	GCA_000062885	405948.11	640069329	405948	99.38
67770	ASM256406v1 assembly for Saccharopolyspora erythraea NRRL 2338 DSM 40517	contig	GCA_002564065	405948.30	2630968997	405948	79.46
67770	ASM17163v1 assembly for Saccharopolyspora erythraea NRRL 2338	contig	GCA_000171635	405948.14	647000310	405948	30.81

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Saccharopolyspora erythraea gene for 16S ribosomal RNA, partial sequence, strain: JCM 4748	D44332	121		405948
20218	Saccharopolyspora erythraea 16S rRNA (part.)	X53198	1327		405948

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Heterologous activation and metabolites identification of the pks7 gene cluster from Saccharopolyspora erythraea.	Tang H, Yang X, Wang W, Cui X, Wei W, Wu J, Sun P, Ye BC.	Synth Syst Biotechnol	10.1016/j.synbio.2024.05.004	2024
	Oxygen determines the requirement for cobalamin but not riboflavin in the growth of Propionibacterium freudenreichii.	Zhang R, Sha Y, Chamlagain B, Edelmann M, Savijoki K, Piironen V, Deptula P, Varmanen P.	Sci Rep	10.1038/s41598-025-12983-8	2025
Enzymology	The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines.	Cardenas-Fernandez M, Roddan R, Carter EM, Hailes HC, Ward JM.	ChemCatChem	10.1002/cctc.202201126	2023
Metabolism	GntR Family Regulator DasR Controls Acetate Assimilation by Directly Repressing the acsA Gene in Saccharopolyspora erythraea.	You D, Zhang BQ, Ye BC.	J Bacteriol	10.1128/jb.00685-17	2018
Metabolism	Phosphate regulator PhoP directly and indirectly controls transcription of the erythromycin biosynthesis genes in Saccharopolyspora erythraea.	Xu Y, You D, Yao LL, Chu X, Ye BC.	Microb Cell Fact	10.1186/s12934-019-1258-y	2019
Genetics	Metagenomic analysis of soybean endosphere microbiome to reveal signatures of microbes for health and disease.	Chouhan U, Gamad U, Choudhari JK.	J Genet Eng Biotechnol	10.1186/s43141-023-00535-4	2023
Enzymology	Eis, a novel family of arylalkylamine N-acetyltransferase (EC 2.3.1.87).	Pan Q, Zhao FL, Ye BC.	Sci Rep	10.1038/s41598-018-20802-6	2018
Metabolism	PccD Regulates Branched-Chain Amino Acid Degradation and Exerts a Negative Effect on Erythromycin Production in Saccharopolyspora erythraea.	Xu Z, Liu Y, Ye BC.	Appl Environ Microbiol	10.1128/aem.00049-18	2018
Metabolism	Identification and characterization of two types of amino acid-regulated acetyltransferases in actinobacteria.	Lu YX, Liu XX, Liu WB, Ye BC.	Biosci Rep	10.1042/bsr20170157	2017
Metabolism	TetR Family Transcriptional Regulator PccD Negatively Controls Propionyl Coenzyme A Assimilation in Saccharopolyspora erythraea.	Xu Z, Wang M, Ye BC.	J Bacteriol	10.1128/jb.00281-17	2017
	GlnR and PhoP Directly Regulate the Transcription of Genes Encoding Starch-Degrading, Amylolytic Enzymes in Saccharopolyspora erythraea.	Xu Y, Liao CH, Yao LL, Ye X, Ye BC.	Appl Environ Microbiol	10.1128/aem.02117-16	2016
Metabolism	Acetyl coenzyme A synthetase is acetylated on multiple lysine residues by a protein acetyltransferase with a single Gcn5-type N-acetyltransferase (GNAT) domain in Saccharopolyspora erythraea.	You D, Yao LL, Huang D, Escalante-Semerena JC, Ye BC.	J Bacteriol	10.1128/jb.01961-14	2014
Metabolism	Reciprocal Regulation of GlnR and PhoP in Response to Nitrogen and Phosphate Limitations in Saccharopolyspora erythraea.	Yao LL, Ye BC.	Appl Environ Microbiol	10.1128/aem.02960-15	2016
	An isotopic labeling approach linking natural products with biosynthetic gene clusters.	McCaughey CS, van Santen JA, van der Hooft JJJ, Medema MH, Linington RG.	Nat Chem Biol	10.1038/s41589-021-00949-6	2022
Metabolism	Random transposon mutagenesis of the Saccharopolyspora erythraea genome reveals additional genes influencing erythromycin biosynthesis.	Fedashchin A, Cernota WH, Gonzalez MC, Leach BI, Kwan N, Wesley RK, Weber JM.	FEMS Microbiol Lett	10.1093/femsle/fnv180	2015
	The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds.	Buyachuihan L, Reiners S, Zhao Y, Grininger M.	Commun Chem	10.1038/s42004-024-01269-1	2024
Metabolism	Biotransformation and recovery of the isoflavones genistein and daidzein from industrial antibiotic fermentations.	Weber JM, Reeves AR, Seshadri R, Cernota WH, Gonzalez MC, Gray DL, Wesley RK.	Appl Microbiol Biotechnol	10.1007/s00253-013-4839-4	2013
Metabolism	An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strain.	Weber JM, Cernota WH, Gonzalez MC, Leach BI, Reeves AR, Wesley RK.	Appl Microbiol Biotechnol	10.1007/s00253-011-3650-3	2012
Metabolism	Knockout of the erythromycin biosynthetic cluster gene, eryBI, blocks isoflavone glucoside bioconversion during erythromycin fermentations in Aeromicrobium erythreum but not in Saccharopolyspora erythraea.	Reeves AR, Seshadri R, Brikun IA, Cernota WH, Gonzalez MC, Weber JM.	Appl Environ Microbiol	10.1128/aem.01759-08	2008
	The secondary metabolites of rare actinomycetes: chemistry and bioactivity.	Ding T, Yang LJ, Zhang WD, Shen YH.	RSC Adv	10.1039/c9ra03579f	2019
	Analysis of an 8.1-kb DNA fragment contiguous with the erythromycin gene cluster of Saccharopolyspora erythraea in the eryCI-flanking region.	Reeves AR, Weber G, Cernota WH, Weber JM.	Antimicrob Agents Chemother	10.1128/aac.46.12.3892-3899.2002	2002
Metabolism	Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production.	Reeves AR, Brikun IA, Cernota WH, Leach BI, Gonzalez MC, Weber JM.	Metab Eng	10.1016/j.ymben.2007.02.001	2007
	DNA in antibiotic preparations: absence of intact resistance genes.	Woegerbauer M, Lagler H, Graninger W, Burgmann H.	Antimicrob Agents Chemother	10.1128/aac.49.6.2490-2494.2005	2005
	Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli.	Paulus TJ, Tuan JS, Luebke VE, Maine GT, DeWitt JP, Katz L.	J Bacteriol	10.1128/jb.172.5.2541-2546.1990	1990
Pathogenicity	Microbial conversion of avermectins by Saccharopolyspora erythraea: glycosylation at C-4' and C-4''.	Schulman M, Doherty P, Arison B.	Antimicrob Agents Chemother	10.1128/aac.37.9.1737	1993
Metabolism	Cytosine deaminase as a negative selection marker for gene disruption and replacement in the genus Streptomyces and other actinobacteria.	Dubeau MP, Ghinet MG, Jacques PE, Clermont N, Beaulieu C, Brzezinski R.	Appl Environ Microbiol	10.1128/aem.02139-08	2009
	Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics.	Wong WR, Oliver AG, Linington RG.	Chem Biol	10.1016/j.chembiol.2012.09.014	2012
Metabolism	Microbial conversion products of leptomycin B.	Kuhnt M, Bitsch F, Ponelle M, Sanglier JJ, Wang Y, Wolff B.	Appl Environ Microbiol	10.1128/aem.64.2.714-720.1998	1998
Metabolism	Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved conditions for expression of secondary metabolites from actinomycetes.	Zahn JA, Higgs RE, Hilton MD.	Appl Environ Microbiol	10.1128/aem.67.1.377-386.2001	2001
	Bacteriophages of Saccharopolyspora erythraea.	Grund AD, Hutchinson CR.	J Bacteriol	10.1128/jb.169.7.3013-3022.1987	1987
	Transduction of plasmid DNA in Streptomyces spp. and related genera by bacteriophage FP43.	McHenney MA, Baltz RH.	J Bacteriol	10.1128/jb.170.5.2276-2282.1988	1988
Metabolism	Denitrification by actinomycetes and purification of dissimilatory nitrite reductase and azurin from Streptomyces thioluteus.	Shoun H, Kano M, Baba I, Takaya N, Matsuo M.	J Bacteriol	10.1128/jb.180.17.4413-4415.1998	1998
Phylogeny	Distribution and phylogenetic analysis of family 19 chitinases in Actinobacteria.	Kawase T, Saito A, Sato T, Kanai R, Fujii T, Nikaidou N, Miyashita K, Watanabe T.	Appl Environ Microbiol	10.1128/aem.70.2.1135-1144.2004	2004
	Biosensor-based dual-color droplet microfluidic platform for precise high-throughput screening of erythromycin hyperproducers.	Zhao L, Li S, Yang Y, Qi L, Zhu Q, Zhao Y, Qi H, Liao X, Zhang Y, Wang M.	Biosens Bioelectron	10.1016/j.bios.2025.117376	2025
Genetics	CRISPR/Cas9-Mediated Promoter Engineering in Saccharopolyspora erythraea.	Zhang Y, Qi H, Wang M.	Methods Mol Biol	10.1007/978-1-0716-4063-0_8	2024
	Transcriptomics-guided optimization of vitamins to enhance erythromycin yield in saccharopolyspora erythraea.	Ke X, Jiang X, Wang S, Tian X, Chu J.	Bioresour Bioprocess	10.1186/s40643-024-00817-w	2024
	Fusariumpernambucanum Causing Leaf Yellow Spot on Melon (Cucumis melo), a New Disease in China	Gao JL, Gao M, Wang LW, Sun PN, Sun YC, Xing XW, Wang J, Zhang XH, Sun JG.	Plant Dis		2024
Genetics	Oxford Nanopore long read-based shotgun metagenomic data sets of simulated bacterial communities originating from fresh spinach and surface water.	Chen Z, Grim CJ, Ramachandran P, Meng J.	Microbiol Resour Announc	10.1128/mra.00586-24	2024
Phylogeny	Characterization of Silver Carbonate Nanoparticles Biosynthesized Using Marine Actinobacteria and Exploring of Their Antimicrobial and Antibiofilm Activity.	Messaoudi O, Benamar I, Azizi A, Albukhaty S, Khane Y, Sulaiman GM, Salem-Bekhit MM, Hamdi K, Ghoummid S, Zoukel A, Messahli I, Kerchich Y, Benaceur F, Salem MM, Bendahou M.	Mar Drugs	10.3390/md21100536	2023
Biotechnology	Copy number variants impact phenotype-genotype relationships for adaptation of industrial yeast Saccharomyces cerevisiae.	Liu ZL, Huang X.	Appl Microbiol Biotechnol	10.1007/s00253-022-12137-0	2022
	Flavacol and Its Novel Derivative 3-beta-Hydroxy Flavacol from Streptomyces sp. Pv 4-95 after the Expression of Heterologous AdpA.	Tistechok S, Stierhof M, Kachor A, Myronovskyi M, Gromyko O, Luzhetskyy A.	Microorganisms	10.3390/microorganisms10122335	2022
Biotechnology	Reasons for 2-furaldehyde and 5-hydroxymethyl-2-furaldehyde resistance in Saccharomyces cerevisiae: current state of knowledge and perspectives for further improvements.	Liu ZL.	Appl Microbiol Biotechnol	10.1007/s00253-021-11256-4	2021
Genetics	An improved Lodderomyces elongisporus NRRL YB-4239 genome assembly substantiated by its electrophoretic karyotype.	Hoyer LL, Hogan EK, Freeman BA, Walden KKO, Hernandez AG.	Microbiol Resour Announc	10.1128/mra.00596-23	2023
	Droplet-Microfluidic-Based Promoter Engineering and Expression Fine-Tuning for Improved Erythromycin Production in Saccharopolyspora erythraea NRRL 23338.	Yun K, Zhang Y, Li S, Wang Y, Tu R, Liu H, Wang M.	Front Bioeng Biotechnol	10.3389/fbioe.2022.864977	2022
	Draft Genome Sequence of Terrestrial Streptomyces sp. Strain VITNK9, Isolated from Vellore, Tamil Nadu, India, Exhibiting Antagonistic Activity against Fish Pathogens.	Saha S, Ishaque NM, Burgsdorf I, Macho M, Ewe D, Steindler L, Hrouzek P, Kannabiran K, Saurav K.	Microbiol Resour Announc	10.1128/mra.01282-20	2021
Biotechnology	Saccharopolyspora sp. NFXS83 in Marine Biotechnological Applications: From Microalgae Growth Promotion to the Production of Secondary Metabolites.	Bertrand CDF, Martins R, Quintas-Nunes F, Reynolds-Brandao P, Crespo MTB, Nascimento FX.	Microorganisms	10.3390/microorganisms11040902	2023
	Role of fourteen XRE-DUF397 pairs from Streptomyces coelicolor as regulators of antibiotic production and differentiation. New players in a complex regulatory network.	Riascos C, Martinez-Carrasco A, Diaz M, Santamaria RI.	Front Microbiol	10.3389/fmicb.2023.1217350	2023
Metabolism	The Modulation of SCO2730/31 Copper Chaperone/Transporter Orthologue Expression Enhances Secondary Metabolism in Streptomycetes.	Gonzalez-Quinonez N, Gutierrez-Del-Rio I, Garcia-Cancela P, Fernandez-Garcia G, Alonso-Fernandez S, Yague P, Perez-Valero A, Montes-Bayon M, Lombo F, Manteca A.	Int J Mol Sci	10.3390/ijms221810143	2021
	Engineering the Erythromycin-Producing Strain Saccharopolyspora erythraea HOE107 for the Heterologous Production of Polyketide Antibiotics.	Lu J, Long Q, Zhao Z, Chen L, He W, Hong J, Liu K, Wang Y, Pang X, Deng Z, Tao M.	Front Microbiol	10.3389/fmicb.2020.593217	2020
	Efficacy of powdered alfalfa leaves to ameliorate the toxic effects of aflatoxin B1 in turkey poults.	Nava-Ramirez MJ, Maguey-Gonzalez JA, Gomez-Rosales S, Hernandez-Ramirez JO, Latorre JD, Du X, Lopez-Coello C, Hargis BM, Tellez-Isaias G, Vazquez-Duran A, Mendez-Albores A.	Mycotoxin Res	10.1007/s12550-024-00527-4	2024
	Identification and Heterologous Expression of the Kendomycin B Biosynthetic Gene Cluster from Verrucosispora sp. SCSIO 07399.	Chen J, Zhang S, Chen Y, Tian X, Gu Y, Ju J.	Mar Drugs	10.3390/md19120673	2021
	Distribution and functional analysis of the phosphopantetheinyl transferase superfamily in Actinomycetales microorganisms.	Kim JH, Komatsu M, Shin-Ya K, Omura S, Ikeda H.	Proc Natl Acad Sci U S A	10.1073/pnas.1800715115	2018
	Development of an Improved System for the Generation of Knockout Mutants of Amycolatopsis sp. Strain ATCC 39116.	Meyer F, Pupkes H, Steinbuchel A.	Appl Environ Microbiol	10.1128/aem.02660-16	2017
	Comparative genomics of the niche-specific plant pathogen Streptomyces ipomoeae reveal novel genome content and organization.	Soares NR, Huguet-Tapia JC, Guan D, Clark CA, Yang K-T, Kluchka OR, Thombal RS, Kartika R, Badger JH, Pettis GS.	Appl Environ Microbiol	10.1128/aem.00308-23	2023
	Draft Genome Sequence of Amycolatopsis decaplanina Strain DSM 44594T.	Kaur N, Kumar S, Bala M, Raghava GP, Mayilraj S.	Genome Announc	10.1128/genomea.00138-13	2013
	Comprehensive genome analysis of Lentzea reveals repertoire of polymer-degrading enzymes and bioactive compounds with clinical relevance.	Maiti PK, Mandal S.	Sci Rep	10.1038/s41598-022-12427-7	2022
Genetics	Comparative functional genomics of the acarbose producers reveals potential targets for metabolic engineering.	Xie H, Zhao Q, Zhang X, Kang Q, Bai L.	Synth Syst Biotechnol	10.1016/j.synbio.2019.01.001	2019
Metabolism	Zn-dependent bifunctional proteases are responsible for leader peptide processing of class III lanthipeptides.	Chen S, Xu B, Chen E, Wang J, Lu J, Donadio S, Ge H, Wang H.	Proc Natl Acad Sci U S A	10.1073/pnas.1815594116	2019
Phylogeny	Genome Content and Phylogenomics Reveal both Ancestral and Lateral Evolutionary Pathways in Plant-Pathogenic Streptomyces Species.	Huguet-Tapia JC, Lefebure T, Badger JH, Guan D, Pettis GS, Stanhope MJ, Loria R.	Appl Environ Microbiol	10.1128/aem.03504-15	2016
	Enzymatic Hydrolysis of Bitter Sorghum for Bioethanol Production	Deenanathe ED, Iyuke SD, Lindsay D.	Technical quarterly - Master Brewers Association of the Americas.		2010
	Identification of Microbial Populations Associated with Sorghum Fermentation	Deenanath ED, Iyuke SE, Lindsay D.	Technical quarterly - Master Brewers Association of the Americas.		2010
Metabolism	Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae.	Rebets Y, Tokovenko B, Lushchyk I, Ruckert C, Zaburannyi N, Bechthold A, Kalinowski J, Luzhetskyy A.	BMC Genomics	10.1186/1471-2164-15-885	2014
Metabolism	New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant.	Zhang S, Zhu J, Zechel DL, Jessen-Trefzer C, Eastman RT, Paululat T, Bechthold A.	Chembiochem	10.1002/cbic.201700428	2018
	Draft genome sequence of Actinomadura sp. K4S16 and elucidation of the nonthmicin biosynthetic pathway.	Komaki H, Harunari E, Ichikawa N, Hosoyama A, Hamada M, Duangmal K, Thamchaipenet A, Igarashi Y.	J Genomics	10.7150/jgen.44650	2020
	S-Adenosylmethionine (SAM)-Dependent Methyltransferase MftM is Responsible for Methylation of the Redox Cofactor Mycofactocin.	Ellerhorst M, Barth SA, Graca AP, Al-Jammal WK, Pena-Ortiz L, Vilotijevic I, Lackner G.	ACS Chem Biol	10.1021/acschembio.2c00659	2022
Metabolism	Insoluble glucans from planktonic and biofilm cultures of mutants of Leuconostoc mesenteroides NRRL B-1355.	Cote GL, Leathers TD.	Appl Microbiol Biotechnol	10.1007/s00253-008-1767-9	2009
Metabolism	Biofilm formation by exopolysaccharide mutants of Leuconostoc mesenteroides strain NRRL B-1355.	Leathers TD, Cote GL.	Appl Microbiol Biotechnol	10.1007/s00253-008-1384-7	2008
Metabolism	Actinobacterial acyl coenzyme A synthetases involved in steroid side-chain catabolism.	Casabon I, Swain K, Crowe AM, Eltis LD, Mohn WW.	J Bacteriol	10.1128/jb.01012-13	2014
Metabolism	Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction.	Hara R, Yamagata K, Miyake R, Kawabata H, Uehara H, Kino K.	Appl Environ Microbiol	10.1128/aem.00693-17	2017
Enzymology	Cryptic polyketide synthase genes in non-pathogenic Clostridium SPP.	Behnken S, Hertweck C.	PLoS One	10.1371/journal.pone.0029609	2012
Genetics	Biosynthetic novelty index reveals the metabolic potential of rare actinobacteria isolated from highly oligotrophic sediments.	Gonzalez-Salazar LA, Quezada M, Rodriguez-Orduna L, Ramos-Aboites H, Capon RJ, Souza-Saldivar V, Barona-Gomez F, Licona-Cassani C.	Microb Genom	10.1099/mgen.0.000921	2023
Genetics	Comparative genomics of the dormancy regulons in mycobacteria.	Gerasimova A, Kazakov AE, Arkin AP, Dubchak I, Gelfand MS.	J Bacteriol	10.1128/jb.00179-11	2011
Metabolism	A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.	Sasaki E, Ogasawara Y, Liu HW.	J Am Chem Soc	10.1021/ja1014037	2010
Pathogenicity	Effect of spice hydrosols on the growth of Aspergillus parasiticus NRRL 2999 strain.	Ozcan M.	J Med Food	10.1089/jmf.2005.8.275	2005
	Pyridine Nucleotide Coenzyme Specificity of p-Hydroxybenzoate Hydroxylase and Related Flavoprotein Monooxygenases.	Westphal AH, Tischler D, Heinke F, Hofmann S, Groning JAD, Labudde D, van Berkel WJH.	Front Microbiol	10.3389/fmicb.2018.03050	2018
	Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae.	Strobel T, Al-Dilaimi A, Blom J, Gessner A, Kalinowski J, Luzhetska M, Puhler A, Szczepanowski R, Bechthold A, Ruckert C.	BMC Genomics	10.1186/1471-2164-13-465	2012
	Transformation of alternan-producing strains of Leuconostoc by electroporation	Leathers TD, Jones JD, Wyckoff HA.	Biotechnol Lett		2004
Metabolism	Transformation of alternan-producing strains of Leuconostoc by electroporation.	Leathers TD, Jones JD, Wyckoff HA.	Biotechnol Lett	10.1023/b:bile.0000035482.41491.7e	2004
Metabolism	Structural elucidation of a novel erythromycin, 13-cyclopentyl-13-desethyl-erythromycin B, from a recombinant Saccharopolyspora erythraea strain, NRRL 2338 pIG/1.	Parsons IC, Everett JR, Pacey MS, Ruddock JC, Swanson AG, Thompson CM.	J Antibiot (Tokyo)	10.7164/antibiotics.52.190	1999
Metabolism	Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643.	Brown MS, Dirlam JP, McArthur HA, McCormick EL, Morse BK, Murphy PA, O'Connell TN, Pacey M, Rescek DM, Ruddock J, Wax RG.	J Antibiot (Tokyo)	10.7164/antibiotics.52.742	1999
	Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.	Komatsu M, Komatsu K, Koiwai H, Yamada Y, Kozone I, Izumikawa M, Hashimoto J, Takagi M, Omura S, Shin-ya K, Cane DE, Ikeda H.	ACS Synth Biol	10.1021/sb3001003	2013
	Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor.	Alam MT, Takano E, Breitling R.	BMC Res Notes	10.1186/1756-0500-4-325	2011
Metabolism	Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.	Imai Y, Sato S, Tanaka Y, Ochi K, Hosaka T.	Appl Environ Microbiol	10.1128/aem.04214-14	2015
Genetics	Whole genome sequencing for deciphering the resistome of Chryseobacterium indologenes, an emerging multidrug-resistant bacterium isolated from a cystic fibrosis patient in Marseille, France.	Cimmino T, Rolain JM.	New Microbes New Infect	10.1016/j.nmni.2016.03.006	2016
Enzymology	Purification and biochemical characterization of the ErmSF macrolide-lincosamide-streptogramin B resistance factor protein expressed as a hexahistidine-tagged protein in Escherichia coli.	Jin HJ, Yang YD.	Protein Expr Purif	10.1006/prep.2002.1621	2002
	Cellulosic Ethanol Production Using a Dual Functional Novel Yeast.	Liu ZL, Dien BS.	Int J Microbiol	10.1155/2022/7853935	2022
Enzymology	novPTMenzy: a database for enzymes involved in novel post-translational modifications.	Khater S, Mohanty D.	Database (Oxford)	10.1093/database/bav039	2015
Phylogeny	Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages.	Shulse CN, Allen EE.	PLoS One	10.1371/journal.pone.0020146	2011
	Plasticity of Streptomyces coelicolor Membrane Composition Under Different Growth Conditions and During Development.	Sandoval-Calderon M, Nguyen DD, Kapono CA, Herron P, Dorrestein PC, Sohlenkamp C.	Front Microbiol	10.3389/fmicb.2015.01465	2015
	In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.	Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S.	J Am Chem Soc	10.1021/ja053704n	2005
Metabolism	The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.	Keller U, Lang M, Crnovcic I, Pfennig F, Schauwecker F.	J Bacteriol	10.1128/jb.01526-09	2010
Metabolism	Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.	Wu X, Flatt PM, Xu H, Mahmud T.	Chembiochem	10.1002/cbic.200800527	2009
Enzymology	Kinetic, mutational, and structural analysis of malonate semialdehyde decarboxylase from Coryneform bacterium strain FG41: mechanistic implications for the decarboxylase and hydratase activities.	Guo Y, Serrano H, Poelarends GJ, Johnson WH, Hackert ML, Whitman CP.	Biochemistry	10.1021/bi400567a	2013
Metabolism	Cloning, Expression and Characterization of a Thermostable Esterase HydS14 from Actinomadura sp. Strain S14 in Pichia pastoris.	Sriyapai P, Kawai F, Siripoke S, Chansiri K, Sriyapai T.	Int J Mol Sci	10.3390/ijms160613579	2015
Metabolism	Some structural features of an insoluble alpha-D-glucan from a mutant strain of Leuconostoc mesenteroides NRRL B-1355.	Cote GL, Ahlgren JA, Smith MR.	J Ind Microbiol Biotechnol	10.1038/sj.jim.2900678	1999
Genetics	Comparative genomic analysis of Brevibacterium strains: insights into key genetic determinants involved in adaptation to the cheese habitat.	Pham NP, Layec S, Dugat-Bony E, Vidal M, Irlinger F, Monnet C.	BMC Genomics	10.1186/s12864-017-4322-1	2017
	Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.	Flinspach K, Kapitzke C, Tocchetti A, Sosio M, Apel AK.	PLoS One	10.1371/journal.pone.0090499	2014
Metabolism	F420H2-dependent degradation of aflatoxin and other furanocoumarins is widespread throughout the actinomycetales.	Lapalikar GV, Taylor MC, Warden AC, Scott C, Russell RJ, Oakeshott JG.	PLoS One	10.1371/journal.pone.0030114	2012
	In silico characterization of pectate lyase protein sequences from different source organisms.	Dubey AK, Yadav S, Kumar M, Singh VK, Sarangi BK, Yadav D.	Enzyme Res	10.4061/2010/950230	2010
	Multi-CAR: a tool of contig scaffolding using multiple references.	Chen KT, Chen CJ, Shen HT, Liu CL, Huang SH, Lu CL.	BMC Bioinformatics	10.1186/s12859-016-1328-7	2016
Metabolism	Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.	Nepal KK, Wang G.	Biotechnol Adv	10.1016/j.biotechadv.2018.10.003	2019
	Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis.	Stassi D, Donadio S, Staver MJ, Katz L.	J Bacteriol	10.1128/jb.175.1.182-189.1993	1993
	Prokaryotic gene clusters: a rich toolbox for synthetic biology.	Fischbach M, Voigt CA.	Biotechnol J	10.1002/biot.201000181	2010
Metabolism	Insights into the evolution of lanthipeptide biosynthesis.	Yu Y, Zhang Q, van der Donk WA.	Protein Sci	10.1002/pro.2358	2013
	Growth and Aflatoxin Production by Aspergillus parasiticus NRRL 2999 as Affected by the Fungicide Iprodione 1.	Arino AA, Bullerman LB.	J Food Prot	10.4315/0362-028x-56.8.718	1993
Metabolism	Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions.	Robertsen HL, Musiol-Kroll EM, Ding L, Laiple KJ, Hofeditz T, Wohlleben W, Lee SY, Grond S, Weber T.	Sci Rep	10.1038/s41598-018-21507-6	2018
	PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis.	Vicente CM, Santos-Aberturas J, Guerra SM, Payero TD, Martin JF, Aparicio JF.	Microb Cell Fact	10.1186/1475-2859-8-33	2009
Metabolism	Differential proteomic profiling reveals regulatory proteins and novel links between primary metabolism and spinosad production in Saccharopolyspora spinosa.	Yang Q, Ding X, Liu X, Liu S, Sun Y, Yu Z, Hu S, Rang J, He H, He L, Xia L.	Microb Cell Fact	10.1186/1475-2859-13-27	2014
Genetics	Using Genomics to Shape the Definition of the Agglutinin-Like Sequence (ALS) Family in the Saccharomycetales.	Oh SH, Schliep K, Isenhower A, Rodriguez-Bobadilla R, Vuong VM, Fields CJ, Hernandez AG, Hoyer LL.	Front Cell Infect Microbiol	10.3389/fcimb.2021.794529	2021
Genetics	CAR: contig assembly of prokaryotic draft genomes using rearrangements.	Lu CL, Chen KT, Huang SY, Chiu HT.	BMC Bioinformatics	10.1186/s12859-014-0381-3	2014
Metabolism	Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework.	Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W.	ACS Chem Biol	10.1021/cb900133x	2009
	Encoded expansion: an efficient algorithm to discover identical string motifs.	Azmi AM, Al-Ssulami A.	PLoS One	10.1371/journal.pone.0095148	2014
Metabolism	Multiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis.	Fayed B, Ashford DA, Hashem AM, Amin MA, El Gazayerly ON, Gregory MA, Smith MC.	Appl Environ Microbiol	10.1128/aem.02403-15	2015
Metabolism	Functional characterization of a vanillin dehydrogenase in Corynebacterium glutamicum.	Ding W, Si M, Zhang W, Zhang Y, Chen C, Zhang L, Lu Z, Chen S, Shen X.	Sci Rep	10.1038/srep08044	2015
Phylogeny	The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems.	Newton-Foot M, Warren RM, Sampson SL, van Helden PD, Gey van Pittius NC.	BMC Evol Biol	10.1186/s12862-016-0631-2	2016
Genetics	Genomic basis for natural product biosynthetic diversity in the actinomycetes.	Nett M, Ikeda H, Moore BS.	Nat Prod Rep	10.1039/b817069j	2009
	Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis.	Liu LL, Xu Y, Han Z, Li YX, Lu L, Lai PY, Zhong JL, Guo XR, Zhang XX, Qian PY.	Mar Drugs	10.3390/md10112571	2012
	Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity.	Liu T, Kharel MK, Zhu L, Bright SA, Mattingly C, Adams VR, Rohr J.	Chembiochem	10.1002/cbic.200800348	2009
	Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase.	Andersen JF, Hutchinson CR.	J Bacteriol	10.1128/jb.174.3.725-735.1992	1992
Metabolism	Plasmid DNA in the erythromycin producing microorganism, Streptomyces erythreus NRRL 2338.	Yi-guang W, Davies JE, Hutchinson CR.	J Antibiot (Tokyo)	10.7164/antibiotics.35.335	1982
Metabolism	Evolution of enzymatic activities in the enolase superfamily: stereochemically distinct mechanisms in two families of cis,cis-muconate lactonizing enzymes.	Sakai A, Fedorov AA, Fedorov EV, Schnoes AM, Glasner ME, Brown S, Rutter ME, Bain K, Chang S, Gheyi T, Sauder JM, Burley SK, Babbitt PC, Almo SC, Gerlt JA.	Biochemistry	10.1021/bi802277h	2009
	Cloning, characterization, and heterologous expression of the Saccharopolyspora erythraea (Streptomyces erythraeus) gene encoding an EF-hand calcium-binding protein.	Swan DG, Cortes J, Hale RS, Leadlay PF.	J Bacteriol	10.1128/jb.171.10.5614-5619.1989	1989
Enzymology	Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus.	Takagi M, Tamaki H, Miyamoto Y, Leonardi R, Hanada S, Jackowski S, Chohnan S.	J Bacteriol	10.1128/jb.01021-09	2010
Metabolism	Signature pathway expression of xylose utilization in the genetically engineered industrial yeast Saccharomyces cerevisiae.	Feng Q, Liu ZL, Weber SA, Li S.	PLoS One	10.1371/journal.pone.0195633	2018
Metabolism	Flavin-dependent N-hydroxylating enzymes: distribution and application.	Mugge C, Heine T, Baraibar AG, van Berkel WJH, Paul CE, Tischler D.	Appl Microbiol Biotechnol	10.1007/s00253-020-10705-w	2020
Metabolism	Two New Native beta-Glucosidases from Clavispora NRRL Y-50464 Confer Its Dual Function as Cellobiose Fermenting Ethanologenic Yeast.	Wang X, Liu ZL, Weber SA, Zhang X.	PLoS One	10.1371/journal.pone.0151293	2016
Phylogeny	Phenotypic and genotypic properties of Microbacterium yannicii, a recently described multidrug resistant bacterium isolated from a lung transplanted patient with cystic fibrosis in France.	Sharma P, Diene SM, Thibeaut S, Bittar F, Roux V, Gomez C, Reynaud-Gaubert M, Rolain JM.	BMC Microbiol	10.1186/1471-2180-13-97	2013
Genetics	Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.	Chandra G, Chater KF.	FEMS Microbiol Rev	10.1111/1574-6976.12047	2014
Pathogenicity	Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.	Bihlmaier C, Welle E, Hofmann C, Welzel K, Vente A, Breitling E, Muller M, Glaser S, Bechthold A.	Antimicrob Agents Chemother	10.1128/aac.00007-06	2006
	Recognition Site Generated by Natural Changes in Erm Proteins Leads to Unexpectedly High Susceptibility to Chymotrypsin.	Le T, Lee HJ, Jin HJ.	ACS Omega	10.1021/acsomega.7b00446	2017
Metabolism	Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis.	Gebhard S, Busby JN, Fritz G, Moreland NJ, Cook GM, Lott JS, Baker EN, Money VA.	J Bacteriol	10.1128/jb.01965-14	2014
Genetics	Chassis optimization as a cornerstone for the application of synthetic biology based strategies in microbial secondary metabolism.	Beites T, Mendes MV.	Front Microbiol	10.3389/fmicb.2015.00906	2015
Metabolism	Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics.	Anzai Y, Li S, Chaulagain MR, Kinoshita K, Kato F, Montgomery J, Sherman DH.	Chem Biol	10.1016/j.chembiol.2008.07.014	2008
	Cloning, characterization, and high-level expression in Escherichia coli of the Saccharopolyspora erythraea gene encoding an acyl carrier protein potentially involved in fatty acid biosynthesis.	Revill WP, Leadlay PF.	J Bacteriol	10.1128/jb.173.14.4379-4385.1991	1991
Enzymology	Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus).	Vara J, Lewandowska-Skarbek M, Wang YG, Donadio S, Hutchinson CR.	J Bacteriol	10.1128/jb.171.11.5872-5881.1989	1989
Metabolism	A walk into the LuxR regulators of Actinobacteria: phylogenomic distribution and functional diversity.	Santos CL, Correia-Neves M, Moradas-Ferreira P, Mendes MV.	PLoS One	10.1371/journal.pone.0046758	2012
	SIS: a program to generate draft genome sequence scaffolds for prokaryotes.	Dias Z, Dias U, Setubal JC.	BMC Bioinformatics	10.1186/1471-2105-13-96	2012
	Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea.	Weber JM, Leung JO, Maine GT, Potenz RH, Paulus TJ, DeWitt JP.	J Bacteriol	10.1128/jb.172.5.2372-2383.1990	1990
Enzymology	Identification of a fungal 1,8-cineole synthase from Hypoxylon sp. with specificity determinants in common with the plant synthases.	Shaw JJ, Berbasova T, Sasaki T, Jefferson-George K, Spakowicz DJ, Dunican BF, Portero CE, Narvaez-Trujillo A, Strobel SA.	J Biol Chem	10.1074/jbc.m114.636159	2015
Genetics	A systematic study of the whole genome sequence of Amycolatopsis methanolica strain 239T provides an insight into its physiological and taxonomic properties which correlate with its position in the genus.	Tang B, Xie F, Zhao W, Wang J, Dai S, Zheng H, Ding X, Cen X, Liu H, Yu Y, Zhou H, Zhou Y, Zhang L, Goodfellow M, Zhao GP.	Synth Syst Biotechnol	10.1016/j.synbio.2016.05.001	2016
	Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.	He Y, Sun Y, Liu T, Zhou X, Bai L, Deng Z.	Appl Environ Microbiol	10.1128/aem.02262-09	2010
Metabolism	Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae.	Zalacain M, Cundliffe E.	J Bacteriol	10.1128/jb.171.8.4254-4260.1989	1989
Genetics	Information theoretic perspective on genome clustering.	Veluchamy A, Mehta P, Srividhya KV, Vikram H, Govind MK, Gupta R, Aziz Bin Dukhyil A, Abdullah Alharbi R, Abdullah Aloyuni S, Hassan MM, Krishnaswamy S.	Saudi J Biol Sci	10.1016/j.sjbs.2020.12.039	2021
Enzymology	Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins.	Begley M, Cotter PD, Hill C, Ross RP.	Appl Environ Microbiol	10.1128/aem.00730-09	2009
	Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.	Haft DH.	BMC Genomics	10.1186/1471-2164-12-21	2011
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
Metabolism	Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis.	Sasaki E, Zhang X, Sun HG, Lu MY, Liu TL, Ou A, Li JY, Chen YH, Ealick SE, Liu HW.	Nature	10.1038/nature13256	2014
Enzymology	Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinase.	Santini S, Monchois V, Mouz N, Sigoillot C, Rousselle T, Claverie JM, Abergel C.	BMC Struct Biol	10.1186/1472-6807-8-33	2008
Transcriptome	In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.	Marsh AJ, O'Sullivan O, Ross RP, Cotter PD, Hill C.	BMC Genomics	10.1186/1471-2164-11-679	2010
	Functional Promiscuity of Homologues of the Bacterial ArsA ATPases.	Castillo R, Saier MH.	Int J Microbiol	10.1155/2010/187373	2010
	Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.	Kamimiya S, Weisblum B.	J Bacteriol	10.1128/jb.170.4.1800-1811.1988	1988
	Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family.	Silverio AL, Saier MH.	J Membr Biol	10.1007/s00232-011-9364-8	2011
	Insertion sequences.	Mahillon J, Chandler M.	Microbiol Mol Biol Rev	10.1128/mmbr.62.3.725-774.1998	1998
Metabolism	Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.	Bibb MJ, Biro S, Motamedi H, Collins JF, Hutchinson CR.	EMBO J	10.1002/j.1460-2075.1989.tb08414.x	1989
Metabolism	Production of aflatoxin on rice.	Shotwell OL, Hesseltine CW, Stubblefield RD, Sorenson WG.	Appl Microbiol	10.1128/am.14.3.425-428.1966	1966
Metabolism	ABC transporters involved in export of cell surface glycoconjugates.	Cuthbertson L, Kos V, Whitfield C.	Microbiol Mol Biol Rev	10.1128/mmbr.00009-10	2010
Phylogeny	Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.	Gao B, Gupta RS.	Microbiol Mol Biol Rev	10.1128/mmbr.05011-11	2012
	Compilation of small ribosomal subunit RNA structures.	Neefs JM, Van de Peer Y, De Rijk P, Chapelle S, De Wachter R.	Nucleic Acids Res	10.1093/nar/21.13.3025	1993
	Enhancing erythromycin production by Saccharopolyspora erythraea E3::sucBA in chemically defined medium.	Ke X, Wang S, Jiang X, Li X, Chu J, Tian X.	Bioresour Technol	10.1016/j.biortech.2025.133730	2025
	Re-engineering a transferase scaffold for indole C3 methylation in diketopiperazines.	Haase M, Weiergraber OH, Pietruszka J.	Protein Sci	10.1002/pro.70254	2025
Genetics	A whole-genome study suggests a taxonomic rearrangement of Saccharopolyspora subtropica as a later heterotypic synonym of Saccharopolyspora thermophila and Saccharopolyspora spinosporotrichia as a later heterotypic synonym of Saccharopolyspora erythraea.	Dif G, Djemouai N, Meklat A, Zitouni A.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006731	2025
	Succinylome Profiling the Function and Distribution of Lysine Succinylation in Saccharopolyspora erythraea.	Ke X, Jiang X, Hussain MH, Tian X, Chu J.	Appl Biochem Biotechnol	10.1007/s12010-024-05176-y	2025
	Tunable dynamic engineering of cellular NAD boosts the production of antibiotics in actinomycetes.	Wu P, Xu Z, Meng Z, Chen K, Lin H, Zhang M, Zhang L, Zhang B, Wu H.	Trends Biotechnol	10.1016/j.tibtech.2025.06.003	2025
	Redefining the role of the EryM acetyltransferase in natural product biosynthetic pathways.	Li Y, Liu X, Harris NR, Roberts JR, Valdivia EM, Ji X, Smith JL.	Structure	10.1016/j.str.2025.05.011	2025
	Metabolic Blockade-Based Genome Mining of Saccharopolyspora erythraea SCSIO 07745: Discovery and Biosynthetic Pathway of Aminoquinolinone Alkaloids Bearing 6/6/5 Tricyclic and 6/6/6/5 Tetracyclic Scaffolds.	Li K, Zhu H, Sun C, Tian G, Ma X, Saravana Kumar P, Weng X, Yang H, Fang R, Liu W, Shang Z, Ma J, Ju J.	Org Lett	10.1021/acs.orglett.4c04491	2025
	Enhancing erythromycin production in Saccharopolyspora erythraea through rational engineering and fermentation refinement: A Design-Build-Test-Learn approach.	Shao M, Xu F, Ke X, Huang M, Chu J.	Biotechnol J	10.1002/biot.202400039	2024
	Glucose-1-phosphate thymidylyltransferase promotes the production of 3-O-alpha-mycarosylerythronolide B in Streptomyces coelicolor.	Gao H, Langer S, Larson T, Gregory MA, Smith MCM.	J Appl Microbiol	10.1093/jambio/lxae291	2024
	An inducible CRISPRi circuit for tunable dynamic regulation of gene expression in Saccharopolyspora erythraea	Jiang X, Ke X, Tian X, Chu J.	Biotechnol Lett.		2024
Metabolism	Engineering the TCA cycle regulator GarA to increase erythromycin production in Saccharopolyspora erythraea.	Liuzzi AD, Tompkins HL, Pallett SK, Webster L, Mukamolova GV, Gregory MA, Sim M, O'Hare HM.	Microbiology (Reading)	10.1099/mic.0.001583	2025
	An inducible CRISPRi circuit for tunable dynamic regulation of gene expression in Saccharopolyspora erythraea.	Jiang X, Ke X, Tian X, Chu J.	Biotechnol Lett	10.1007/s10529-023-03462-z	2024
	Engineering Streptomyces albus B4 for Enhanced Production of (R)-Mellein: A High-Titer Heterologous Biosynthesis Approach.	Tang H, Wei W, Wu J, Cui X, Wang W, Qian T, Wo J, Ye BC.	J Agric Food Chem	10.1021/acs.jafc.4c02463	2024
	Ammonium sulfate supplementation enhances erythromycin biosynthesis by augmenting intracellular metabolism and precursor supply in Saccharopolyspora erythraea.	Yuan Y, Xu F, Ke X, Lu J, Huang M, Chu J.	Bioprocess Biosyst Eng	10.1007/s00449-023-02898-x	2023
	High-Frequency Microfluidic Fractionation for Compound-Resolved Bioactivity-Based Metabolomics.	Geibel C, Schubert J, Knoblauch SB, Hernandez A, Boldt L, Schneider DC, Papadopoulos Lambidis S, Vitale GA, Fleischer J, Haussmann M, Gross H, Wang M, Brotz-Oesterhelt H, Petras D.	Anal Chem	10.1021/acs.analchem.5c04612	2025
	dTSR enables efficient improvement of heterologous production of spinosad in Saccharopolyspora erythraea.	He W, Lu J, Bai L, Deng Z, Tao M.	Synth Syst Biotechnol	10.1016/j.synbio.2025.02.003	2025
	[Rational design of a 500 m3 fermenter for erythromycin production by Saccharopolyspora erythraea].	Tan X, Li C, Guo M.	Sheng Wu Gong Cheng Xue Bao	10.13345/j.cjb.220292	2022
	Modulating Sensitivity of an Erythromycin Biosensor for Precise High-Throughput Screening of Strains with Different Characteristics.	Wang Y, Li S, Xue N, Wang L, Zhang X, Zhao L, Guo Y, Zhang Y, Wang M.	ACS Synth Biol	10.1021/acssynbio.3c00059	2023
Genetics	Genome scale metabolic model combined with single molecule real-time sequencing to analyze Actinomycete chromosomal heterogeneity.	Han B, Li Z, Li Z.	Gene	10.1016/j.gene.2022.146959	2023
	Chameleon-like microbes promote microecological differentiation of Daqu	Yang L, Fan W, Xu Y.	Food Microbiology.		2023
	Whole-Cell Biosensor and Producer Co-cultivation-Based Microfludic Platform for Screening Saccharopolyspora erythraea with Hyper Erythromycin Production.	Hua E, Zhang Y, Yun K, Pan W, Liu Y, Li S, Wang Y, Tu R, Wang M.	ACS Synth Biol	10.1021/acssynbio.2c00102	2022
	Complete sequences of pIJ101-based Streptomyces-Escherichia coli shuttle vectors.	Brown KV, Nybo SE.	Access Microbiol	10.1099/acmi.0.000893.v3	2024
	Chameleon-like microbes promote microecological differentiation of Daqu.	Yang L, Fan W, Xu Y.	Food Microbiol	10.1016/j.fm.2022.104144	2023
	Acyltransferase Domain Swapping for the Production of Tenvermectin B Metabolites in Genetically Engineered Strain Streptomyces avermitilis HU02.	Zhang H, Zhang S, Zhang J, Qi H, Wang H, Zhang L, Huang J, Wang J.	J Agric Food Chem	10.1021/acs.jafc.2c04482	2022
	Exploring the metabolic fate of propanol in industrial erythromycin-producing strain via 13C labeling experiments and enhancement of erythromycin production by rational metabolic engineering of Saccharopolyspora erythraea.	Xu F, Ke X, Hong M, Huang M, Chen C, Tian X, Hang H, Chu J.	Biochem Biophys Res Commun	10.1016/j.bbrc.2021.01.024	2021
	The Roles of Carbon-Nitrogen Synergy and Phosphate Regulation in Producing Higher Yield of Vancomycin by Amycolatopsis orientalis.	Mani V, Jeyachandran S, Aman M.	Microbiologyopen	10.1002/mbo3.70072	2025
	Joint engineering of SACE_Lrp and its target MarR enhances the biosynthesis and export of erythromycin in Saccharopolyspora erythraea.	Liu J, Li L, Wang Y, Li B, Cai X, Tang L, Dong S, Yang E, Wu H, Zhang B.	Appl Microbiol Biotechnol	10.1007/s00253-021-11228-8	2021
Metabolism	Engineering the TetR-family transcriptional regulator XNR_0706 to enhance heterologous spinosad production in Streptomyces albus B4 chassis.	Cui X, Tang H, Wang W, Wei W, Wu J, Ye BC.	Synth Syst Biotechnol	10.1016/j.synbio.2024.08.008	2025
	Metagenomics-based insights into the microbial community profiling and flavor development potentiality of baijiu Daqu and huangjiu wheat Qu	Zhang J, Liu S, Sun H, Jiang Z, Xu Y, Mao J, Qian B, Wang L, Mao J.	Food Res Int		2022
Metabolism	Metabolomic analysis of the impact of MtrA on carbon metabolism in Streptomyces coelicolor.	Zhu Y, Zhang H, Pang X.	Microbiol Spectr	10.1128/spectrum.00096-25	2025
	TetR family regulator AbrT controls lincomycin production and morphological development in Streptomyces lincolnensis.	Xu Y, Liu M, Zhao R, Pan Y, Wu P, Zhang C, Chi X, Zhang B, Wu H.	Microb Cell Fact	10.1186/s12934-024-02498-8	2024
	CRISPR/Cas9-Mediated Multi-Locus Promoter Engineering in ery Cluster to Improve Erythromycin Production in Saccharopolyspora erythraea.	Zhang X, Wang Y, Zhang Y, Wang M.	Microorganisms	10.3390/microorganisms11030623	2023
Genetics	Metagenomics-based insights into the microbial community profiling and flavor development potentiality of baijiu Daqu and huangjiu wheat Qu.	Zhang J, Liu S, Sun H, Jiang Z, Xu Y, Mao J, Qian B, Wang L, Mao J.	Food Res Int	10.1016/j.foodres.2021.110707	2022
Metabolism	Cofactor Engineering Redirects Secondary Metabolism and Enhances Erythromycin Production in Saccharopolyspora erythraea.	Li X, Chen J, Andersen JM, Chu J, Jensen PR.	ACS Synth Biol	10.1021/acssynbio.9b00528	2020
	Effect of Castor Oil on Bioprocess Parameters of Erythromycin Fermentation by Saccharopolyspora Erythraea.	Kianinejad N, Labbeiki G, Attar H.	Iran J Biotechnol	10.30498/ijb.2021.242170.2827	2021
	Allosteric regulation by c-di-AMP modulates a complete N-acetylglucosamine signaling cascade in Saccharopolyspora erythraea.	You D, Zhao LC, Fu Y, Peng ZY, Chen ZQ, Ye BC.	Nat Commun	10.1038/s41467-024-48063-0	2024
Metabolism	Co-cultivation strategies for natural product discovery from actinomycetes: unlocking silent secondary metabolism with mycolic acid-containing bacteria.	Asamizu S.	World J Microbiol Biotechnol	10.1007/s11274-025-04406-7	2025
	Cryo-electron microscopy structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis.	Johnston HE, Batt SM, Brown AK, Savva CG, Besra GS, Futterer K.	Microbiology (Reading)	10.1099/mic.0.001505	2024
	A CRISPR-Cas9 Strategy for Activating the Saccharopolyspora erythraea Erythromycin Biosynthetic Gene Cluster with Knock-in Bidirectional Promoters.	Liu Y, Ren CY, Wei WP, You D, Yin BC, Ye BC.	ACS Synth Biol	10.1021/acssynbio.9b00024	2019
Genetics	In silico identification of silent primycin biosynthetic gene clusters within the family Pseudonocardiaceae.	Kovacs-Valasek M, Fekete C, Kovacs-Valasek A.	Heliyon	10.1016/j.heliyon.2024.e41065	2025
Metabolism	Characterization and engineering of the Lrp/AsnC family regulator SACE_5717 for erythromycin overproduction in Saccharopolyspora erythraea.	Liu J, Chen Y, Li L, Yang E, Wang Y, Wu H, Zhang L, Wang W, Zhang B.	J Ind Microbiol Biotechnol	10.1007/s10295-019-02178-2	2019
	Heterologous Expression of the Formicamycin Biosynthetic Gene Cluster Unveils Glycosylated Fasamycin Congeners.	McDonald HP, Alford A, Devine R, Hems ES, Nepogodiev SA, Arnold CJ, Rejzek M, Stanley-Smith A, Holmes NA, Hutchings MI, Wilkinson B.	J Nat Prod	10.1021/acs.jnatprod.3c00052	2023
	A network of acetyl phosphate-dependent modification modulates c-di-AMP homeostasis in Actinobacteria.	Fu Y, Zhao L-C, Shen J-L, Zhou S-Y, Yin B-C, Ye B-C, You D.	mBio	10.1128/mbio.01411-24	2024
	PhoP- and GlnR-mediated regulation of metK transcription and its impact upon S-adenosyl-methionine biosynthesis in Saccharopolyspora erythraea.	Pei JF, Li YX, Tang H, Wei W, Ye BC.	Microb Cell Fact	10.1186/s12934-022-01846-w	2022
Metabolism	Lysine propionylation modulates the transcriptional activity of phosphate regulator PhoP in Saccharopolyspora erythraea.	Xu Y, Li YX, Ye BC.	Mol Microbiol	10.1111/mmi.14122	2018
	SacAcuA/SacSrtN system modulates the metabolism by controlling the special proteins in Saccharopolyspora erythraea	Zhou Y, Li ZH, Ye BC.	Ann Microbiol		2018
Genetics	High GC Content Cas9-Mediated Genome-Editing and Biosynthetic Gene Cluster Activation in Saccharopolyspora erythraea.	Liu Y, Wei WP, Ye BC.	ACS Synth Biol	10.1021/acssynbio.7b00448	2018
Genetics	Reconstruction of the Genome-Scale Metabolic Model of Saccharopolyspora erythraea and Its Application in the Overproduction of Erythromycin.	Xu F, Lu J, Ke X, Shao M, Huang M, Chu J.	Metabolites	10.3390/metabo12060509	2022
	Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products.	Covington BC, Seyedsayamdost MR.	Nat Prod Rep	10.1039/d4np00026a	2025
Genetics	Improving butenyl-spinosyn production in Saccharopolyspora pogona through combination of metabolic engineering and medium optimization.	Zhao X, Lu H, Peng S, Hang H, Aldahmash W, Al-Ghadi MQ, Tang W, Pei J, Xun W, Guo M, Mohsin A.	Front Microbiol	10.3389/fmicb.2025.1561042	2025
	Lrp Family Regulator SCAB_Lrp2 Responds to the Precursor Tryptophan and Represses the Thaxtomin Biosynthesis in Streptomyces scabies.	He H, Tang L, Song M, Chen H, Zou Y, Li X, Yang E, Wu H, Zhang B, Liu J.	Mol Plant Pathol	10.1111/mpp.70036	2024
	Overproduction of Erythromycin by Ultraviolet Mutagenesis and Expression of ermE Gene in Saccharopolyspora erythraea.	Fallahpour N, Adnani S, Rassi H, Asli E.	Assay Drug Dev Technol	10.1089/adt.2017.802	2017
	Impact of the Deletion of Genes of the Nitrogen Metabolism on Triacylglycerol, Cardiolipin and Actinorhodin Biosynthesis in Streptomyces coelicolor.	Abreu S, Lejeune C, David M, Chaminade P, Virolle MJ.	Microorganisms	10.3390/microorganisms12081560	2024
Metabolism	GlnR and PhoP regulate beta-glucosidases involved in cellulose digestion in response to nitrogen and phosphate availability.	Xu Y, Ye BC.	Microbiology (Reading)	10.1099/mic.0.000654	2018
	How c-di-GMP controls progression through the Streptomyces life cycle.	Gallagher KA, Tschowri N, Brennan RG, Schumacher MA, Buttner MJ.	Curr Opin Microbiol	10.1016/j.mib.2024.102516	2024
Metabolism	Metabolomics for industrial fermentation.	Choi KR, Kim WJ, Lee SY.	Bioprocess Biosyst Eng	10.1007/s00449-018-1967-3	2018
Metabolism	Developmental regulator BldD directly regulates lincomycin biosynthesis in Streptomyces lincolnensis.	Li J, Wang N, Tang Y, Cai X, Xu Y, Liu R, Wu H, Zhang B.	Biochem Biophys Res Commun	10.1016/j.bbrc.2019.08.079	2019
	Strategic Acyl Carrier Protein Engineering Enables Functional Type II Polyketide Synthase Reconstitution In Vitro.	Li K, Cho YI, Tran MA, Wiedemann C, Zhang S, Koweek RS, Hoang NK, Hamrick GS, Bowen MA, Kokona B, Stallforth P, Beld J, Hellmich UA, Charkoudian LK.	ACS Chem Biol	10.1021/acschembio.4c00678	2025
	Repurposing a Fully Reducing Polyketide Synthase toward 2-Methyl Guerbet-like Lipids.	Herrera MA, McColm S, Craigie LM, Simpson J, Brown F, Clarke DJ, Carr R, Campopiano DJ.	ACS Catal	10.1021/acscatal.4c04714	2024
Metabolism	13C-assisted metabolomics analysis reveals the positive correlation between specific erythromycin production rate and intracellular propionyl-CoA pool size in Saccharopolyspora erythraea.	Hong M, Mou H, Liu X, Huang M, Chu J.	Bioprocess Biosyst Eng	10.1007/s00449-017-1792-0	2017
	Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus.	Sarrazin M, Poncin I, Fourquet P, Audebert S, Camoin L, Denis Y, Santucci P, Spilling CD, Kremer L, Le Moigne V, Herrmann JL, Cavalier JF, Canaan S.	J Biomed Sci	10.1186/s12929-024-01091-w	2024
	Uncovering and Engineering a Mini-Regulatory Network of the TetR-Family Regulator SACE_0303 for Yield Improvement of Erythromycin in Saccharopolyspora erythraea.	Liu Y, Khan S, Wu P, Li B, Liu L, Ni J, Zhang H, Chen K, Wu H, Zhang B.	Front Bioeng Biotechnol	10.3389/fbioe.2021.692901	2021
Enzymology	Comparative structural analysis provides new insights into the function of R2-like ligand-binding oxidase.	Diamanti R, Srinivas V, Johansson AI, Nordstrom A, Griese JJ, Lebrette H, Hogbom M.	FEBS Lett	10.1002/1873-3468.14319	2022
Proteome	DNA origami-enhanced force spectroscopy and AlphaFold structural analyses reveal the folding landscape of calcium-binding proteins.	Zhang H, Canari-Chumpitaz C, Alexander L, Zhang H, Fan C, Bustamante C.	Sci Adv	10.1126/sciadv.adv1962	2025
Transcriptome	Priestia megaterium Metabolism: Isolation, Identification of Naringenin Analogues and Genes Elevated Associated with Nanoparticle Intervention.	Al-Theyab NS, Abuelizz HA, Al-Hamoud GA, Aldossary A, Liang M.	Curr Issues Mol Biol	10.3390/cimb45080424	2023
	Effect of TetR Family Transcriptional Regulator PccD on Phytosterol Metabolism of Mycolicibacterium.	Xiao P, Pan D, Li F, Liu Y, Huang Y, Zhou X, Zhang Y.	Microorganisms	10.3390/microorganisms12112349	2024
Enzymology	Bioinformatic prediction of the stereoselectivity of modular polyketide synthase: an update of the sequence motifs in ketoreductase domain.	Xiang C, Yao S, Wang R, Zhang L.	Beilstein J Org Chem	10.3762/bjoc.20.131	2024
	Application of In Vitro Transposon Mutagenesis to Erythromycin Strain Improvement in Saccharopolyspora erythraea.	Weber JM, Reeves A, Cernota WH, Wesley RK.	Methods Mol Biol	10.1007/978-1-4939-6472-7_17	2017
Metabolism	Blocking the flow of propionate into TCA cycle through a mutB knockout leads to a significant increase of erythromycin production by an industrial strain of Saccharopolyspora erythraea.	Chen C, Hong M, Chu J, Huang M, Ouyang L, Tian X, Zhuang Y.	Bioprocess Biosyst Eng	10.1007/s00449-016-1687-5	2017
Enzymology	Acetyl-CoA synthetases of Saccharopolyspora erythraea are regulated by the nitrogen response regulator GlnR at both transcriptional and post-translational levels.	You D, Wang MM, Ye BC.	Mol Microbiol	10.1111/mmi.13595	2017
	Reconstruction of Secondary Metabolic Pathway to Synthesize Novel Metabolite in Saccharopolyspora erythraea.	Ren CY, Liu Y, Wei WP, Dai J, Ye BC.	Front Bioeng Biotechnol	10.3389/fbioe.2021.628569	2021
	A Combinatorial Approach of High-Throughput Genomics and Mass Proteomics for Understanding the Regulation and Expression of Secondary Metabolite Production in Actinobacteria.	Gupta V, Singhvi N.	mSystems	10.1128/msystems.00862-21	2021
Metabolism	Impacts of proline on the central metabolism of an industrial erythromycin-producing strain Saccharopolyspora erythraea via (13)C labeling experiments.	Hong M, Huang M, Chu J, Zhuang Y, Zhang S.	J Biotechnol	10.1016/j.jbiotec.2016.05.026	2016
	The PurR family transcriptional regulator promotes butenyl-spinosyn production in Saccharopolyspora pogona.	Li X, Wang J, Su C, Guo C, Xu Z, Wang K, Pang J, Lv B, Wang C, Li C.	Appl Microbiol Biotechnol	10.1007/s00253-024-13390-1	2025
	The global nitrogen regulator GlnR is a direct transcriptional repressor of the key gluconeogenic gene pckA in actinomycetes.	Liu X, Wang X, Shao Z, Dang J, Wang W, Liu C, Wang J, Yuan H, Zhao G.	J Bacteriol	10.1128/jb.00003-24	2024
	Engineering of an Lrp family regulator SACE_Lrp improves erythromycin production in Saccharopolyspora erythraea.	Liu J, Chen Y, Wang W, Ren M, Wu P, Wang Y, Li C, Zhang L, Wu H, Weaver DT, Zhang B.	Metab Eng	10.1016/j.ymben.2016.10.012	2017
Metabolism	Lysine Malonylome May Affect the Central Metabolism and Erythromycin Biosynthesis Pathway in Saccharopolyspora erythraea.	Xu JY, Xu Z, Zhou Y, Ye BC.	J Proteome Res	10.1021/acs.jproteome.6b00131	2016
Metabolism	Nitrogen regulator GlnR directly controls transcription of genes encoding lysine deacetylases in Actinobacteria.	Xu Y, You D, Ye BC.	Microbiology (Reading)	10.1099/mic.0.000553	2017
	Highly parallel bending tests for fungal hyphae enabled by two-photon polymerization of microfluidic mold.	Brinkmann S, Schrader M, Meinen S, Kampen I, Kwade A, Dietzel A.	Front Bioeng Biotechnol	10.3389/fbioe.2024.1449167	2024
Proteome	Quantitative Proteomic Analysis of Lysine Malonylation in Response to Salicylic Acid in the Roots of Platycodon grandiflorus.	Ding W, Duan Y, Wang Y, Fan J, Rao W, Xing S.	Int J Mol Sci	10.3390/ijms26031392	2025
	Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential.	Greunke C, Duell ER, D'Agostino PM, Glockle A, Lamm K, Gulder TAM.	Metab Eng	10.1016/j.ymben.2018.03.010	2018
Enzymology	Protocol for the purification, analysis, and handling of acyl carrier proteins from type I fatty acid and polyketide synthases.	Gusenda C, Berlage S, Burkhart I, Chagot B, Weissman KJ, Schwalbe H, Grininger M.	STAR Protoc	10.1016/j.xpro.2025.103762	2025
	Antioxidant and Pro-Oxidant Properties of Selected Clinically Applied Antibiotics: Therapeutic Insights.	Maliar T, Blazkova M, Polak J, Maliarova M, Urgeova E, Viskupicova J.	Pharmaceuticals (Basel)	10.3390/ph17101257	2024
Metabolism	Protein Acylation is a General Regulatory Mechanism in Biosynthetic Pathway of Acyl-CoA-Derived Natural Products.	Xu JY, Xu Y, Xu Z, Zhai LH, Ye Y, Zhao Y, Chu X, Tan M, Ye BC.	Cell Chem Biol	10.1016/j.chembiol.2018.05.005	2018
	Enhanced Natamycin production in Streptomyces gilvosporeus through phosphate tolerance screening and transcriptome-based analysis of high-yielding mechanisms.	Wang L, Xiao W, Qiu T, Zhang H, Zhang J, Chen X.	Microb Cell Fact	10.1186/s12934-025-02696-y	2025
	Bioinformatic identification of ClpI, a distinct class of Clp unfoldases in Actinomycetota.	Jiang J, Schmitz KR.	Front Microbiol	10.3389/fmicb.2023.1161764	2023
Metabolism	DasR is a pleiotropic regulator required for antibiotic production, pigment biosynthesis, and morphological development in Saccharopolyspora erythraea.	Liao CH, Xu Y, Rigali S, Ye BC.	Appl Microbiol Biotechnol	10.1007/s00253-015-6892-7	2015
Metabolism	In vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea.	Wu H, Li W, Xin C, Zhang C, Wang Y, Ren S, Ren M, Zhao W, Yuan L, Xu Z, Yuan H, Geng M, Zhang L, Weaver DT, Zhang B.	Appl Microbiol Biotechnol	10.1007/s00253-015-7036-9	2016
Enzymology	On the phosphorylase activity of GH3 enzymes: A beta-N-acetylglucosaminidase from Herbaspirillum seropedicae SmR1 and a glucosidase from Saccharopolyspora erythraea.	Ducatti DR, Carroll MA, Jakeman DL.	Carbohydr Res	10.1016/j.carres.2016.09.015	2016
	Unveiling the Secrets of Calcium-Dependent Proteins in Plant Growth-Promoting Rhizobacteria: An Abundance of Discoveries Awaits.	Agaras BC, Grossi CEM, Ulloa RM.	Plants (Basel)	10.3390/plants12193398	2023
	Unveiling the microbial communities and metabolic pathways of Keem, a traditional starter culture, through whole-genome sequencing.	Rana B, Chandola R, Sanwal P, Joshi GK.	Sci Rep	10.1038/s41598-024-53350-3	2024
Metabolism	Lysine acetylproteome analysis suggests its roles in primary and secondary metabolism in Saccharopolyspora erythraea.	Huang D, Li ZH, You D, Zhou Y, Ye BC.	Appl Microbiol Biotechnol	10.1007/s00253-014-6144-2	2015
Genetics	Exploring Tetraselmis chui microbiomes-functional metagenomics for novel catalases and superoxide dismutases.	Macdonald JFH, Han Y, Astafyeva Y, Bergmann L, Gurschke M, Dirksen P, Blumke P, Schneider YKH, Alawi M, Lippemeier S, Andersen JH, Krohn I.	Appl Microbiol Biotechnol	10.1007/s00253-024-13395-w	2025
Metabolism	Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolor.	Liu J, Li J, Dong H, Chen Y, Wang Y, Wu H, Li C, Weaver DT, Zhang L, Zhang B.	Appl Microbiol Biotechnol	10.1007/s00253-017-8339-9	2017
	Capturing the target genes of BldD in Saccharopolyspora erythraea using improved genomic SELEX method.	Wu H, Mao Y, Chen M, Pan H, Huang X, Ren M, Wu H, Li J, Xu Z, Yuan H, Geng M, Weaver DT, Zhang L, Zhang B.	Appl Microbiol Biotechnol	10.1007/s00253-014-6255-9	2015
	Three genes encoding citrate synthases in Saccharopolyspora erythraea are regulated by the global nutrient-sensing regulators GlnR, DasR, and CRP.	Liao CH, Yao LL, Ye BC.	Mol Microbiol	10.1111/mmi.12818	2014
	Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2.	Bagde SR, Kim CY.	Nat Prod Rep	10.1039/d3np00060e	2024
	A meet-up of acetyl phosphate and c-di-GMP modulates BldD activity for development and antibiotic production.	Fu Y, Dong YQ, Shen JL, Yin BC, Ye BC, You D.	Nucleic Acids Res	10.1093/nar/gkad494	2023
Metabolism	DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis.	Zhang Y, Lin CY, Li XM, Tang ZK, Qiao J, Zhao GR.	J Ind Microbiol Biotechnol	10.1007/s10295-016-1845-4	2016
Genetics	Exploring extreme environments in Türkiye for novel P450s through metagenomic analysis.	Mumcu H, Zaugg J, Keles I, Kayrav A, Balci N, Nelson DR, Hugenholtz P, Gillam EMJ, Gul Karaguler N.	PLoS One	10.1371/journal.pone.0330523	2025
Transcriptome	Effects of the pleiotropic regulator DasR on lincomycin production in Streptomyces lincolnensis.	Pai H, Liu Y, Zhang C, Su J, Lu W.	Appl Microbiol Biotechnol	10.1007/s00253-024-13201-7	2024
Metabolism	GlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolyspora erythraea.	Yao LL, Liao CH, Huang G, Zhou Y, Rigali S, Zhang B, Ye BC.	Appl Microbiol Biotechnol	10.1007/s00253-014-5878-1	2014
Phylogeny	Streptomyces iakyrus TA 36 as First-Reported Source of Quinone Antibiotic gamma-Rubromycin.	Charousova I, Hlebova M, Hleba L, Medo J, Wink J.	Molecules	10.3390/molecules28165977	2023
	Multi-strategy engineering unusual sugar TDP-l-mycarose biosynthesis to improve the production of 3-O-alpha-mycarosylerythronolide B in Escherichia coli.	Liu Z, Xu J, Feng Z, Wang Y.	Synth Syst Biotechnol	10.1016/j.synbio.2022.03.002	2022
Metabolism	SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea.	Wu P, Pan H, Zhang C, Wu H, Yuan L, Huang X, Zhou Y, Ye BC, Weaver DT, Zhang L, Zhang B.	J Ind Microbiol Biotechnol	10.1007/s10295-014-1449-9	2014
Phylogeny	Age-specific composition of milk microbiota in Tibetan sheep and goats.	Cao X, Fang Y, Bandan P, Suo L, Jiacuo G, Wu Y, Cuoji A, Zhuoga D, Chen Y, Ji, Quzhen C, Zhang K.	Appl Microbiol Biotechnol	10.1007/s00253-024-13252-w	2024
Metabolism	Sirtuin-dependent reversible lysine acetylation of the o-succinylbenzoyl-coenzyme A synthetase of Bacillus subtilis.	Burckhardt RM, Escalante-Semerena JC.	Microbiol Spectr	10.1128/spectrum.02011-24	2024
Metabolism	Control of chitin and N-acetylglucosamine utilization in Saccharopolyspora erythraea.	Liao C, Rigali S, Cassani CL, Marcellin E, Nielsen LK, Ye BC.	Microbiology (Reading)	10.1099/mic.0.078261-0	2014
	Role of two alternate water networks in Compound I formation in P450eryF.	Sen K, Thiel W.	J Phys Chem B	10.1021/jp411272h	2014
	Fluorometric Analysis of Carrier-Protein-Dependent Biosynthesis through a Conformationally Sensitive Solvatochromic Pantetheinamide Probe.	Miyada MG, Choi Y, Stepanauskas R, Woyke T, La Clair JJ, Burkart MD.	ACS Chem Biol	10.1021/acschembio.4c00169	2024
	TrkA of Streptococcus mitis CCUG31611 binds cyclic di-adenosine monophosphate and is required for growth in low potassium conditions.	Vevik K, Sribasgaran B, Cai K, Naemi AO, Pedersen Kaspersen H, Uhlig S, Okstad OA, Simm R.	Microbiology (Reading)	10.1099/mic.0.001597	2025
	Engineering of a TetR family transcriptional regulator BkdR enhances heterologous spinosad production in Streptomyces albus B4 chassis.	Wang W, Tang H, Cui X, Wei W, Wu J, Ye B-C.	Appl Environ Microbiol	10.1128/aem.00838-24	2024
Metabolism	The Expression of NOX From Synthetic Promoters Reveals an Important Role of the Redox Status in Regulating Secondary Metabolism of Saccharopolyspora erythraea.	Li X, Chu J, Jensen PR.	Front Bioeng Biotechnol	10.3389/fbioe.2020.00818	2020
Genetics	Complete Genome Sequence Analysis of Kribbella sp. CA-293567 and Identification of the Kribbellichelins A & B and Sandramycin Biosynthetic Gene Clusters.	Sanchez-Hidalgo M, Garcia MJ, Gonzalez I, Oves-Costales D, Genilloud O.	Microorganisms	10.3390/microorganisms11020265	2023
	The leucine-responsive regulatory protein SCAB_Lrp modulates thaxtomin biosynthesis, pathogenicity, and morphological development in Streptomyces scabies.	Liu J, Wang Y, He H, Dong S, Tang L, Yang E, Wang W, Zhang B.	Mol Plant Pathol	10.1111/mpp.13285	2023
	The DNA cytosine methylome revealed two methylation motifs in the upstream regions of genes related to morphological and physiological differentiation in Streptomyces coelicolor A(3)2 M145.	Pisciotta A, Sampino AM, Presentato A, Galardini M, Manteca A, Alduina R.	Sci Rep	10.1038/s41598-023-34075-1	2023
	The molecular mechanisms of the bacterial iron sensor IdeR.	Marcos-Torres FJ, Juniar L, Griese JJ.	Biochem Soc Trans	10.1042/bst20221539	2023
	From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota.	Tahmasebi H, Arjmand N, Monemi M, Babaeizad A, Alibabaei F, Alibabaei N, Bahar A, Oksenych V, Eslami M.	Biomolecules	10.3390/biom15010093	2025
	Transcriptome-guided target identification of the TetR-like regulator SACE_5754 and engineered overproduction of erythromycin in Saccharopolyspora erythraea.	Wu H, Chu Z, Zhang W, Zhang C, Ni J, Fang H, Chen Y, Wang Y, Zhang L, Zhang B.	J Biol Eng	10.1186/s13036-018-0135-2	2019
Metabolism	Biochemical parameters of Saccharopolyspora erythraea during feeding ammonium sulphate in erythromycin biosynthesis phase.	Zou X, Li WJ, Zeng W, Hang HF, Chu J, Zhuang YP, Zhang SL.	Prikl Biokhim Mikrobiol	10.7868/s0555109913020189	2013
	Accumulation of antibiotic-resistant genes in anaerobic biofilm reactor fed with household chemical products.	Khuntia HK, Chanakya HN.	SN Appl Sci	10.1007/s42452-020-3143-z	2020
	Integrated meta-omics approaches reveal Saccharopolyspora as the core functional genus in huangjiu fermentations.	Liu S, Zhang ZF, Mao J, Zhou Z, Zhang J, Shen C, Wang S, Marco ML, Mao J.	NPJ Biofilms Microbiomes	10.1038/s41522-023-00432-1	2023
	Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria.	Shi J, Feng Z, Xu J, Li F, Zhang Y, Wen A, Wang F, Song Q, Wang L, Cui H, Tong S, Chen P, Zhu Y, Zhao G, Wang S, Feng Y, Lin W.	Proc Natl Acad Sci U S A	10.1073/pnas.2300282120	2023
Enzymology	Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance.	Stsiapanava A, Selmer M.	Sci Rep	10.1038/s41598-019-51174-0	2019
	Antimicrobial Residue Accumulation Contributes to Higher Levels of Rhodococcus equi Carrying Resistance Genes in the Environment of Horse-Breeding Farms.	Higgins C, Cohen ND, Slovis N, Boersma M, Gaonkar PP, Golden DR, Huber L.	Vet Sci	10.3390/vetsci11020092	2024
	Carbon catabolite regulation of secondary metabolite formation, an old but not well-established regulatory system.	Ruiz-Villafan B, Cruz-Bautista R, Manzo-Ruiz M, Passari AK, Villarreal-Gomez K, Rodriguez-Sanoja R, Sanchez S.	Microb Biotechnol	10.1111/1751-7915.13791	2022
Metabolism	Analysis of a draft genome sequence of Kitasatospora cheerisanensis KCTC 2395 producing bafilomycin antibiotics.	Hwang JY, Kim SH, Oh HR, Kwon E, Nam DH.	J Microbiol	10.1007/s12275-015-4340-0	2015
Metabolism	A novel multidomain acyl-CoA carboxylase in Saccharopolyspora erythraea provides malonyl-CoA for de novo fatty acid biosynthesis.	Livieri AL, Navone L, Marcellin E, Gramajo H, Rodriguez E.	Sci Rep	10.1038/s41598-019-43223-5	2019
Transcriptome	Enhancement of acarbose production by genetic engineering and fed-batch fermentation strategy in Actinoplanes sp. SIPI12-34.	Li Z, Yang S, Zhang Z, Wu Y, Tang J, Wang L, Chen S.	Microb Cell Fact	10.1186/s12934-022-01969-0	2022
	Genome Sequence of Saccharopolyspora erythraea D, a Hyperproducer of Erythromycin.	Liu WB, Yu WB, Gao SH, Ye BC.	Genome Announc	10.1128/genomea.00718-13	2013
Metabolism	Structural modification of herboxidiene by substrate-flexible cytochrome P450 and glycosyltransferase.	Jha AK, Dhakal D, Van PT, Pokhrel AR, Yamaguchi T, Jung HJ, Yoon YJ, Sohng JK.	Appl Microbiol Biotechnol	10.1007/s00253-015-6431-6	2015
	Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster.	Eckert N, Rebets Y, Horbal L, Zapp J, Herrmann J, Busche T, Muller R, Kalinowski J, Luzhetskyy A.	Microb Cell Fact	10.1186/s12934-023-02231-x	2023
Metabolism	Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production.	Licona-Cassani C, Marcellin E, Quek LE, Jacob S, Nielsen LK.	Antonie Van Leeuwenhoek	10.1007/s10482-012-9783-2	2012
Transcriptome	Transcriptomic insights into the interplay between polyketide biosynthesis and other secondary metabolite biosynthetic clusters and biological pathways in entomopathogen Beauveria bassiana	Toopaang W, Yoocha T, Naktang C, Wichienchote N, Pechsrichuang P, Tangphatsornruang S, Tanticharoen M, Yang Y, Amnuaykanjanasin A.	Front Microbiol		2025
Genetics	Complete genome sequence, metabolic model construction, and huangjiu application of Saccharopolyspora rosea A22, a thermophilic, high amylase and glucoamylase actinomycetes.	Ma D, Liu S, Han X, Nan M, Xu Y, Qian B, Wang L, Mao J.	Front Microbiol	10.3389/fmicb.2022.995978	2022
	Diversity of Actinobacteria Isolated from Date Palms Rhizosphere and Saline Environments: Isolation, Identification and Biological Activity Evaluation.	Messaoudi O, Wink J, Bendahou M.	Microorganisms	10.3390/microorganisms8121853	2020
	The ssgB gene is required for the early stages of sporangium formation in Actinoplanes missouriensis.	Akutsu T, Tezuka T, Maruko M, Hirata A, Ohnishi Y.	J Bacteriol	10.1128/jb.00428-23	2024
Genetics	Karakum desert: a unique source of cultivable novel and rare actinomycetes with a remarkable biosynthetic potential.	Saygin H, Sahin N, Goodfellow M.	World J Microbiol Biotechnol	10.1007/s11274-025-04399-3	2025
	Calcium modulates growth and biofilm formation of Lactobacillus acidophilus ATCC 4356 and Lactiplantibacillus plantarum ATCC 14917.	Huynh U, King J, Zastrow ML.	Sci Rep	10.1038/s41598-025-98577-w	2025
Metabolism	Asymmetric Stetter reactions catalyzed by thiamine diphosphate-dependent enzymes.	Kasparyan E, Richter M, Dresen C, Walter LS, Fuchs G, Leeper FJ, Wacker T, Andrade SL, Kolter G, Pohl M, Muller M.	Appl Microbiol Biotechnol	10.1007/s00253-014-5850-0	2014
	Integrated analysis of transcriptomics and metabolomics and high-throughput amplicon sequencing reveals the synergistic effects of secondary metabolites and rhizosphere microbiota on root rot resistance in Psammosilene tunicoides.	Yingtao L, Qiaofeng L, Lijuan W, Shuyun Q, Zhou J, Wenping Z, Aili Z.	Front Microbiol	10.3389/fmicb.2025.1554406	2025
	Bio-Derived Furanic Compounds with Natural Metabolism: New Sustainable Possibilities for Selective Organic Synthesis.	Romashov LV, Kucherov FA, Kozlov KS, Ananikov VP.	Int J Mol Sci	10.3390/ijms24043997	2023
Metabolism	Identification of SACE_7040, a member of TetR family related to the morphological differentiation of Saccharopolyspora erythraea.	Han S, Song P, Ren T, Huang X, Cao C, Zhang B.	Curr Microbiol	10.1007/s00284-011-9943-z	2011
	Regulation of Nir gene in Lactobacillus plantarum WU14 mediated by GlnR.	Qiu H, Chang X, Luo Y, Shen F, Yin A, Miao T, Li Y, Xiao Y, Hai J, Xu B.	Front Microbiol	10.3389/fmicb.2022.983485	2022
Enzymology	Malonyl-proteome profiles of Staphylococcus aureus reveal lysine malonylation modification in enzymes involved in energy metabolism.	Shi Y, Zhu J, Xu Y, Tang X, Yang Z, Huang A.	Proteome Sci	10.1186/s12953-020-00169-1	2021
	An atypical two-component system, AtcR/AtcK, simultaneously regulates the biosynthesis of multiple secondary metabolites in Streptomyces bingchenggensis.	Yan Y-S, Zou L-S, Wei H-G, Yang M-Y, Yang Y-Q, Li X-F, Xia H-Y.	Appl Environ Microbiol	10.1128/aem.01300-23	2024
	Improving the production of carbamoyltobramycin by an industrial Streptoalloteichus tenebrarius through metabolic engineering.	Feng Y, Jiang Y, Chen X, Zhu L, Xue H, Wu M, Yang L, Yu H, Lin J.	Appl Microbiol Biotechnol	10.1007/s00253-024-13141-2	2024
	Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP.	De Sciscio ML, Nardi AN, Parisi G, Bulfaro G, Costanzo A, Gugole E, Exertier C, Freda I, Savino C, Vallone B, Montemiglio LC, D'Abramo M.	Molecules	10.3390/molecules28020832	2023
Pathogenicity	Complex natural product production methods and options.	Park D, Swayambhu G, Lyga T, Pfeifer BA.	Synth Syst Biotechnol	10.1016/j.synbio.2020.12.001	2021
Metabolism	Improved heterologous erythromycin A production through expression plasmid re-design.	Jiang M, Fang L, Pfeifer BA.	Biotechnol Prog	10.1002/btpr.1759	2013
	The acetyltransferase SCO0988 controls positively specialized metabolism and morphological differentiation in the model strains Streptomyces coelicolor and Streptomyces lividans.	Bi Y, An H, Chi Z, Xu Z, Deng Y, Ren Y, Wang R, Lu X, Guo J, Hu R, Virolle MJ, Xu D.	Front Microbiol	10.3389/fmicb.2024.1366336	2024
	Flow-cytometric cell sorting coupled with UV mutagenesis for improving pectin lyase expression.	Fang K, Ma J, Wang X, Xu Z, Zhang Z, Li P, Wang R, Wang J, Sun C, Dong Z.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1251342	2023
Transcriptome	Transcriptional regulation of the fidaxomicin gene cluster and cellular development in Actinoplanes deccanensis YP-1 by the pleiotropic regulator MtrA.	Xie H, Ruan J-Y, Bu Q-T, Li Y-P, Su Y-T, Zhao Q-W, Du Y-L, Li Y-Q.	Microbiol Spectr	10.1128/spectrum.02702-23	2023
Transcriptome	Two-Component-System RspA1/A2-Dependent Regulation on Primary Metabolism in Streptomyces albus A30 Cultivated With Glutamate as the Sole Nitrogen Source.	Zhang K, Mohsin A, Yu J, Hu Y, Ali MF, Chen Z, Zhuang Y, Chu J, Guo M.	Front Microbiol	10.3389/fmicb.2020.01658	2020
	Chemoenzymatic synthesis of fluorinated polyketides.	Rittner A, Joppe M, Schmidt JJ, Mayer LM, Reiners S, Heid E, Herzberg D, Sherman DH, Grininger M.	Nat Chem	10.1038/s41557-022-00996-z	2022
Metabolism	Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C and D at different conversion ratios.	Zhang Q, Wu J, Qian J, Chu J, Zhuang Y, Zhang S, Liu W.	Lett Appl Microbiol	10.1111/j.1472-765x.2010.02973.x	2011
Metabolism	Production of a novel O-methyl-isoflavone by regioselective sequential hydroxylation and O-methylation reactions in Streptomyces avermitilis host system.	Choi KY, Jung E, Yang YH, Kim BG.	Biotechnol Bioeng	10.1002/bit.24931	2013
Genetics	Comprehensive whole metagenomics analysis uncovers microbial community and resistome variability across anthropogenically contaminated soils in urban and suburban areas of Tamil Nadu, India.	Vasanthrao R, Nidhin IK, Taj Z, Chattopadhyay I.	Front Microbiol	10.3389/fmicb.2025.1649872	2025
	Construction of over-expression shuttle vectors in Streptomyces	Sun N, Wang ZB, Wu HP, Mao XM, Li YQ.	Ann Microbiol	10.1007/s13213-011-0408-1	2012
Metabolism	Volatile communication in Actinobacteria: a language for secondary metabolism regulation.	Cuervo L, Mendez C, Salas JA, Olano C, Malmierca MG.	Microb Cell Fact	10.1186/s12934-024-02456-4	2024
Metabolism	An assessment of seed quality on erythromycin production by recombinant Saccharopolyspora erythraea strain.	Zou X, Li WJ, Zeng W, Chu J, Zhuang YP, Zhang SL.	Bioresour Technol	10.1016/j.biortech.2010.11.065	2011
Metabolism	The scent of bacteria: headspace analysis for the discovery of natural products.	Citron CA, Rabe P, Dickschat JS.	J Nat Prod	10.1021/np300468h	2012
Enzymology	Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer.	Yan J, Hazzard C, Bonnett SA, Reynolds KA.	Biochemistry	10.1021/bi300830q	2012
Metabolism	Robust reporter system based on chalcone synthase rppA gene from Saccharopolyspora erythraea.	Magdevska V, Gaber R, Goranovic D, Kuscer E, Boakes S, Duran Alonso MB, Santamaria RI, Raspor P, Leadlay PF, Fujs S, Petkovic H.	J Microbiol Methods	10.1016/j.mimet.2010.08.001	2010
	Comparative study of lysine acetylation in Vesicomyidae clam Archivesica marissinica and the manila clam Ruditapes philippinarum: adaptation mechanisms in cold seep environments.	Kong X, Wang W, Chen S, Song M, Zhi Y, Cai Y, Zhang H, Shen X.	BMC Genomics	10.1186/s12864-024-10916-9	2024
	Computer-Aided (In Silico) Modeling of Cytochrome P450-Mediated Food-Drug Interactions (FDI).	Guttman Y, Kerem Z.	Int J Mol Sci	10.3390/ijms23158498	2022
	The Role of Wastewater Treatment Plants in Dissemination of Antibiotic Resistance: Source, Measurement, Removal and Risk Assessment.	Drane K, Sheehan M, Whelan A, Ariel E, Kinobe R.	Antibiotics (Basel)	10.3390/antibiotics13070668	2024
Metabolism	Erythrochelin--a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea.	Robbel L, Knappe TA, Linne U, Xie X, Marahiel MA.	FEBS J	10.1111/j.1742-4658.2009.07512.x	2010
Genetics	Combating Antimicrobial Resistance in the Post-Genomic Era: Rapid Antibiotic Discovery.	Yang Y, Kessler MGC, Marchan-Rivadeneira MR, Han Y, Han Y.	Molecules	10.3390/molecules28104183	2023
	Acetylome and Succinylome Profiling of Edwardsiella tarda Reveals Key Roles of Both Lysine Acylations in Bacterial Antibiotic Resistance.	Fu Y, Zhang L, Song H, Liao J, Lin L, Jiang W, Wu X, Wang G.	Antibiotics (Basel)	10.3390/antibiotics11070841	2022
Metabolism	SACE_0012, a TetR-family transcriptional regulator, affects the morphogenesis of Saccharopolyspora erythraea.	Yin X, Xu X, Wu H, Yuan L, Huang X, Zhang B.	Curr Microbiol	10.1007/s00284-013-0410-x	2013
Metabolism	In vivo trapping of polyketide intermediates from an assembly line synthase using malonyl carba(dethia)-N-acetyl cysteamines.	Tosin M, Demydchuk Y, Parascandolo JS, Per CB, Leeper FJ, Leadlay PF.	Chem Commun (Camb)	10.1039/c0cc05077f	2011
	An aurora of natural products-based drug discovery is coming.	Tong Y, Deng Z.	Synth Syst Biotechnol	10.1016/j.synbio.2020.05.003	2020
Metabolism	CPLM 4.0: an updated database with rich annotations for protein lysine modifications.	Zhang W, Tan X, Lin S, Gou Y, Han C, Zhang C, Ning W, Wang C, Xue Y.	Nucleic Acids Res	10.1093/nar/gkab849	2022
	Efficient editing DNA regions with high sequence identity in actinomycetal genomes by a CRISPR-Cas9 system.	Mo J, Wang S, Zhang W, Li C, Deng Z, Zhang L, Qu X.	Synth Syst Biotechnol	10.1016/j.synbio.2019.02.004	2019
	High frequency transformation of the industrial erythromycin-producing bacterium Saccharopolyspora erythraea	Wang Y, Wang Y, Zhang S.	Biotechnol Lett		2008
Phylogeny	Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity.	Harper CP, Day A, Tsingos M, Ding E, Zeng E, Stumpf SD, Qi Y, Robinson A, Greif J, Blodgett JAV.	Appl Environ Microbiol	10.1128/aem.00600-24	2024
Metabolism	The Enzyme Lysine Malonylation of Calvin Cycle and Gluconeogenesis Regulated Glycometabolism in Nostoc flagelliforme to Adapt to Drought Stress.	Wang M, Zhu Q, Yao N, Liang W, Ma X, Li J, Li X, Wang L, Liang W.	Int J Mol Sci	10.3390/ijms24098446	2023
Metabolism	High Level of Spinosad Production in the Heterologous Host Saccharopolyspora erythraea.	Huang J, Yu Z, Li MH, Wang JD, Bai H, Zhou J, Zheng YG.	Appl Environ Microbiol	10.1128/aem.00618-16	2016
	Specialized Metabolism of Gordonia Genus: An Integrated Survey on Chemodiversity Combined with a Comparative Genomics-Based Analysis.	Sanchez-Suarez J, Diaz L, Coy-Barrera E, Villamil L.	BioTech (Basel)	10.3390/biotech11040053	2022
Metabolism	Enhanced oxygen transfer rate and bioprocess yield by using magnetite nanoparticles in fermentation media of erythromycin.	Labbeiki G, Attar H, Heydarinasab A, Sorkhabadi S, Rashidi A.	Daru	10.1186/s40199-014-0066-5	2014
Metabolism	Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host.	Zhang H, Wang Y, Wu J, Skalina K, Pfeifer BA.	Chem Biol	10.1016/j.chembiol.2010.09.013	2010
Metabolism	Application of oxygen uptake rate and response surface methodology for erythromycin production by Saccharopolyspora erythraea.	Zou X, Hang HF, Chen CF, Chu J, Zhuang YP, Zhang SL.	J Ind Microbiol Biotechnol	10.1007/s10295-008-0407-9	2008
	How Combined Macrolide Nanomaterials are Effective Against Resistant Pathogens? A Comprehensive Review of the Literature.	Siraj EA, Yayehrad AT, Belete A.	Int J Nanomedicine	10.2147/ijn.s418588	2023
Metabolism	High frequency transformation of the industrial erythromycin-producing bacterium Saccharopolyspora erythraea.	Wang Y, Wang Y, Zhang S.	Biotechnol Lett	10.1007/s10529-007-9547-7	2008
Enzymology	Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of C-12 hydroxylase EryK from Saccharopolyspora erythraea.	Savino C, Sciara G, Miele AE, Kendrew SG, Vallone B.	Protein Pept Lett	10.2174/092986608786071201	2008
	Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea.	Wu H, Wang Y, Yuan L, Mao Y, Wang W, Zhu L, Wu P, Fu C, Muller R, Weaver DT, Zhang L, Zhang B.	Synth Syst Biotechnol	10.1016/j.synbio.2016.01.004	2016
	Research progress on GlnR-mediated regulation in Actinomycetes.	Gao B, Li G, Gu D, Wang J.	Front Microbiol	10.3389/fmicb.2023.1282523	2023
Pathogenicity	The transcriptome analysis on urea response mechanism in the process of ergosterol synthesis by Cordyceps cicadae.	Su Q, Zhang Z, Liu X, Wang F.	Sci Rep	10.1038/s41598-021-90377-2	2021
Genetics	Physiological and biochemical characterization and genome analysis of Rhodococcus qingshengii strain 7B capable of crude oil degradation and plant stimulation.	Iminova L, Delegan Y, Frantsuzova E, Bogun A, Zvonarev A, Suzina N, Anbumani S, Solyanikova I.	Biotechnol Rep (Amst)	10.1016/j.btre.2022.e00741	2022
Metabolism	Improvement of erythromycin production by Saccharopolyspora erythraea in molasses based medium through cultivation medium optimization.	El-Enshasy HA, Mohamed NA, Farid MA, El-Diwany AI.	Bioresour Technol	10.1016/j.biortech.2007.08.050	2008
	Transcriptional Regulator DasR Represses Daptomycin Production through Both Direct and Cascade Mechanisms in Streptomyces roseosporus.	Chen Q, Zhu J, Li X, Wen Y.	Antibiotics (Basel)	10.3390/antibiotics11081065	2022
	RclS Sensor Kinase Modulates Virulence of Pseudomonas capeferrum.	Novovic K, Malesevic M, Dinic M, Gardijan L, Kojic M, Jovcic B.	Int J Mol Sci	10.3390/ijms23158232	2022
Metabolism	Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction.	Cogan DP, Li X, Sevillano N, Mathews II, Matsui T, Craik CS, Khosla C.	J Am Chem Soc	10.1021/jacs.0c05133	2020
	Erythromycin Scavenging from Aqueous Solutions by Zeolitic Materials Derived from Fly Ash.	Grela A, Kuc J, Klimek A, Matusik J, Pamula J, Franus W, Urbanski K, Bajda T.	Molecules	10.3390/molecules28020798	2023
Metabolism	Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes.	Wu P, Chen K, Li B, Zhang Y, Wu H, Chen Y, Ren S, Khan S, Zhang L, Zhang B.	mBio	10.1128/mbio.02298-21	2021
Phylogeny	A novel isoquinoline alkaloid, DD-carboxypeptidase inhibitor, with antibacterial activity isolated from Streptomyces sp. 8812. Part I: Taxonomy, fermentation, isolation and biological activities.	Solecka J, Rajnisz A, Laudy AE.	J Antibiot (Tokyo)	10.1038/ja.2009.85	2009
Transcriptome	Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.	Oliynyk M, Samborskyy M, Lester JB, Mironenko T, Scott N, Dickens S, Haydock SF, Leadlay PF.	Nat Biotechnol	10.1038/nbt1297	2007
	Glycosylation engineering of spinosyn analogues containing an L-olivose moiety.	Gaisser S, Carletti I, Schell U, Graupner PR, Sparks TC, Martin CJ, Wilkinson B.	Org Biomol Chem	10.1039/b900233b	2009
	The mud-dwelling clam Meretrix petechialis secretes endogenously synthesized erythromycin.	Yue X, Zhang S, Wang H, Yu J, Peng Q, McFall-Ngai M, Liu B.	Proc Natl Acad Sci U S A	10.1073/pnas.2214150119	2022
Metabolism	Biosynthesis of the putative siderophore erythrochelin requires unprecedented crosstalk between separate nonribosomal peptide gene clusters.	Lazos O, Tosin M, Slusarczyk AL, Boakes S, Cortes J, Sidebottom PJ, Leadlay PF.	Chem Biol	10.1016/j.chembiol.2010.01.011	2010
	Actinoplanes Swims into the Molecular Age.	Buttner MJ.	J Bacteriol	10.1128/jb.00070-17	2017
	Re-annotation of the Saccharopolyspora erythraea genome using a systems biology approach.	Marcellin E, Licona-Cassani C, Mercer TR, Palfreyman RW, Nielsen LK.	BMC Genomics	10.1186/1471-2164-14-699	2013
	Apis andreniformis associated Actinomycetes show antimicrobial activity against black rot pathogen (Xanthomonas campestris pv. campestris).	Promnuan Y, Promsai S, Pathom-Aree W, Meelai S.	PeerJ	10.7717/peerj.12097	2021
	RedEx: a method for seamless DNA insertion and deletion in large multimodular polyketide synthase gene clusters.	Song C, Luan J, Li R, Jiang C, Hou Y, Cui Q, Cui T, Tan L, Ma Z, Tang YJ, Stewart AF, Fu J, Zhang Y, Wang H.	Nucleic Acids Res	10.1093/nar/gkaa956	2020
Biotechnology	Synthetic biology approaches to actinomycete strain improvement.	Breitling R, Avbelj M, Bilyk O, Carratore FD, Filisetti A, Hanko EKR, Iorio M, Redondo RP, Reyes F, Rudden M, Severi E, Slemc L, Schmidt K, Whittall DR, Donadio S, Garcia AR, Genilloud O, Kosec G, De Lucrezia D, Petkovic H, Thomas G, Takano E.	FEMS Microbiol Lett	10.1093/femsle/fnab060	2021
	Predicting the oxidation states of Mn ions in the oxygen-evolving complex of photosystem II using supervised and unsupervised machine learning.	Amin M.	Photosynth Res	10.1007/s11120-022-00941-8	2023
	Midecamycin Is Inactivated by Several Different Sugar Moieties at Its Inactivation Site.	Lin R, Hong LL, Jiang ZK, Li KM, He WQ, Kong JQ.	Int J Mol Sci	10.3390/ijms222312636	2021
Enzymology	Tetramic acid analogues produced by coculture of Saccharopolyspora erythraea with Fusarium pallidoroseum.	Whitt J, Shipley SM, Newman DJ, Zuck KM.	J Nat Prod	10.1021/np400761g	2014
Metabolism	Prediction and characterization of small non-coding RNAs related to secondary metabolites in Saccharopolyspora erythraea.	Liu WB, Shi Y, Yao LL, Zhou Y, Ye BC.	PLoS One	10.1371/journal.pone.0080676	2013
	Acidophilic and Acid Tolerant Actinobacteria as New Sources of Antimicrobial Agents against Helicobacter Pylori.	Eftekharivash L, Hamedi J, Zarrini G, Bakhtiari R.	Arch Razi Inst	10.22092/ari.2019.128039.1401	2021
Metabolism	The bacterial iron sensor IdeR recognizes its DNA targets by indirect readout.	Marcos-Torres FJ, Maurer D, Juniar L, Griese JJ.	Nucleic Acids Res	10.1093/nar/gkab711	2021
Metabolism	Properties of Saccharopolyspora erythraea strains after protoplast regeneration.	Rajnisz A, Solecka J, Kurzatkowski W.	Folia Microbiol (Praha)	10.1007/bf02931288	2005
Metabolism	Identification of erythrobactin, a hydroxamate-type siderophore produced by Saccharopolyspora erythraea.	Oliveira PH, Batagov A, Ward J, Baganz F, Krabben P.	Lett Appl Microbiol	10.1111/j.1472-765x.2006.01849.x	2006
	Identification and characterization of a strong constitutive promoter stnYp for activating biosynthetic genes and producing natural products in streptomyces.	Guo W, Xiao Z, Huang T, Zhang K, Pan HX, Tang GL, Deng Z, Liang R, Lin S.	Microb Cell Fact	10.1186/s12934-023-02136-9	2023
Metabolism	Increased erythromycin production by alginate as a medium ingredient or immobilization support in cultures of Saccharopolyspora erythraea.	Hamedi J, Khodagholi F, Hassani-Nasab A.	Biotechnol Lett	10.1007/s10529-005-4476-9	2005
	Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli.	Liu Z, Xu J, Liu H, Wang Y.	Microb Biotechnol	10.1111/1751-7915.14000	2022
Metabolism	[Biogenesis and regulation of biosynthesis of erythromycins in Saccharopolyspora erythraea: a review].	Mironov VA, Sergienko OV, Nastasiak IN, Danilenko VN.	Prikl Biokhim Mikrobiol	10.1023/b:abim.0000046985.66328.7a	2004
Enzymology	Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea.	Reeves AR, Brikun IA, Cernota WH, Leach BI, Gonzalez MC, Weber JM.	J Ind Microbiol Biotechnol	10.1007/s10295-006-0094-3	2006
Genetics	Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.	Zhao W, Zhong Y, Yuan H, Wang J, Zheng H, Wang Y, Cen X, Xu F, Bai J, Han X, Lu G, Zhu Y, Shao Z, Yan H, Li C, Peng N, Zhang Z, Zhang Y, Lin W, Fan Y, Qin Z, Hu Y, Zhu B, Wang S, Ding X, Zhao GP.	Cell Res	10.1038/cr.2010.87	2010
Metabolism	Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis.	Kumpfmuller J, Methling K, Fang L, Pfeifer BA, Lalk M, Schweder T.	Appl Microbiol Biotechnol	10.1007/s00253-015-6990-6	2016
	Structure and Mechanisms of Assembly-Line Polyketide Synthases.	Soohoo AM, Cogan DP, Brodsky KL, Khosla C.	Annu Rev Biochem	10.1146/annurev-biochem-080923-043654	2024
	Global Identification and Systematic Analysis of Lysine Malonylation in Maize (Zea mays L.).	Xu M, Tian X, Ku T, Wang G, Zhang E.	Front Plant Sci	10.3389/fpls.2021.728338	2021
Metabolism	Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics.	Basnet DB, Park JW, Yoon YJ.	J Biotechnol	10.1016/j.jbiotec.2008.03.001	2008
Metabolism	Improved bioconversion of 15-fluoro-6-deoxyerythronolide B to 15-fluoro-erythromycin A by overexpression of the eryK Gene in Saccharopolyspora erythraea.	Desai RP, Rodriguez E, Galazzo JL, Licari P.	Biotechnol Prog	10.1021/bp0497435	2004
Pathogenicity	[Antioxidant effect on the growth of Saccharopolyspora erythraea and biosynthesis of erythromycins].	Michurina TA, Sergeeva AV, Mironov VA.	Antibiot Khimioter		2005
	Current status and future opportunities for serial crystallography at MAX IV Laboratory.	Shilova A, Lebrette H, Aurelius O, Nan J, Welin M, Kovacic R, Ghosh S, Safari C, Friel RJ, Milas M, Matej Z, Hogbom M, Branden G, Kloos M, Shoeman RL, Doak B, Ursby T, Hakansson M, Logan DT, Mueller U.	J Synchrotron Radiat	10.1107/s1600577520008735	2020
	Melleins-Intriguing Natural Compounds.	Reveglia P, Masi M, Evidente A.	Biomolecules	10.3390/biom10050772	2020
	Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform.	Arsic B, Barber J, Cikos A, Kadirvel M, Kostic E, McBain AJ, Milicevic J, Oates A, Regan A.	Molecules	10.3390/molecules27217280	2022
Enzymology	Purification, cloning, and properties of alpha-galactosidase from Saccharopolyspora erythraea and its use as a reporter system.	Post DA, Luebke VE.	Appl Microbiol Biotechnol	10.1007/s00253-004-1764-6	2005
Metabolism	A new member of the bacterial ribonuclease inhibitor family from Saccharopolyspora erythraea.	Krajcikova D, Hartley RW.	FEBS Lett	10.1016/s0014-5793(03)01468-6	2004
Pathogenicity	Enhancing of erythromycin production by Saccharopolyspora erythraea with common and uncommon oils.	Hamedi J, Malekzadeh F, Saghafi-nia AE.	J Ind Microbiol Biotechnol	10.1007/s10295-004-0166-1	2004
Metabolism	Bacterial Sirtuins Overview: An Open Niche to Explore.	Gallego-Jara J, Ortega A, Lozano Terol G, Sola Martinez RA, Canovas Diaz M, de Diego Puente T.	Front Microbiol	10.3389/fmicb.2021.744416	2021
	Actinomycete integrative and conjugative pMEA-like elements of Amycolatopsis and Saccharopolyspora decoded.	te Poele EM, Samborskyy M, Oliynyk M, Leadlay PF, Bolhuis H, Dijkhuizen L.	Plasmid	10.1016/j.plasmid.2008.01.003	2008
	Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis.	Lin CY, Pang AP, Zhang Y, Qiao J, Zhao GR.	Microb Cell Fact	10.1186/s12934-020-01298-0	2020
	Zinc-Responsive Regulator Zur Regulates Zinc Homeostasis, Secondary Metabolism, and Morphological Differentiation in Streptomyces avermitilis.	Lyu M, Cheng Y, Dai Y, Wen Y, Song Y, Li J, Chen Z.	Appl Environ Microbiol	10.1128/aem.00278-22	2022
Enzymology	A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.	Boakes S, Oliynyk M, Cortes J, Bohm I, Rudd BA, Revill WP, Staunton J, Leadlay PF.	J Mol Microbiol Biotechnol	10.1159/000084562	2004
Metabolism	Impact on Multiple Antibiotic Pathways Reveals MtrA as a Master Regulator of Antibiotic Production in Streptomyces spp. and Potentially in Other Actinobacteria.	Zhu Y, Zhang P, Zhang J, Wang J, Lu Y, Pang X.	Appl Environ Microbiol	10.1128/aem.01201-20	2020
	A novel fluorinated erythromycin antibiotic.	Goss RJ, Hong H.	Chem Commun (Camb)	10.1039/b506635b	2005
Enzymology	Characterization and regulation of NADP+-isocitrate dehydrogenase from Saccharopolyspora erythraea.	Alvarado A, Flores ME.	Biotechnol Lett	10.1023/a:1024542426956	2003
	Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase.	Martin CJ, Timoney MC, Sheridan RM, Kendrew SG, Wilkinson B, Staunton JC, Leadlay PF.	Org Biomol Chem	10.1039/b310740j	2003
	[Study on relationship between length of homologous sequences and chromosomic recombination rate in Saccharopolyspora erythraea].	Zhang BC, Zhao ZH, Wang YG, Yu XQ, Liu CX, Ma QJ.	Sheng Wu Gong Cheng Xue Bao		2003
	A Bioinformatics Analysis Reveals a Group of MocR Bacterial Transcriptional Regulators Linked to a Family of Genes Coding for Membrane Proteins.	Milano T, Angelaccio S, Tramonti A, Di Salvo ML, Contestabile R, Pascarella S.	Biochem Res Int	10.1155/2016/4360285	2016
	Heterologous Production of 6-Deoxyerythronolide B in Escherichia coli through the Wood Werkman Cycle.	Gonzalez-Garcia RA, Nielsen LK, Marcellin E.	Metabolites	10.3390/metabo10060228	2020
Metabolism	NMR solution structure of calerythrin, an EF-hand calcium-binding protein from Saccharopolyspora erythraea.	Tossavainen H, Permi P, Annila A, Kilpelainen I, Drakenberg T.	Eur J Biochem	10.1046/j.1432-1033.2003.03623.x	2003
	Analysis and review of techniques and tools based on machine learning and deep learning for prediction of lysine malonylation sites in protein sequences.	Ramazi S, Tabatabaei SAH, Khalili E, Nia AG, Motarjem K.	Database (Oxford)	10.1093/database/baad094	2024
	Preparation of erythromycin analogs having functional groups at C-15.	Ashley GW, Burlingame M, Desai R, Fu H, Leaf T, Licari PJ, Tran C, Abbanat D, Bush K, Macielag M.	J Antibiot (Tokyo)	10.1038/ja.2006.56	2006
Metabolism	Sirtuin-dependent reversible lysine acetylation of glutamine synthetases reveals an autofeedback loop in nitrogen metabolism.	You D, Yin BC, Li ZH, Zhou Y, Yu WB, Zuo P, Ye BC.	Proc Natl Acad Sci U S A	10.1073/pnas.1525654113	2016
Metabolism	The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis.	Lee SK, Basnet DB, Choi CY, Sohng JK, Ahn JS, Yoon YJ.	Bioorg Chem	10.1016/j.bioorg.2004.06.002	2004
	Effects of Nonionic Surfactants on Xanthan Gum Production: a Survey on Cellular Interactions.	Ghashghaei T, Soudi MR, Hoseinkhani S, Shiri M.	Iran J Biotechnol	10.21859/ijb.1483	2018
	Two strategies to improve the supply of PKS extender units for ansamitocin P-3 biosynthesis by CRISPR-Cas9.	Guo S, Sun X, Li R, Zhang T, Hu F, Liu F, Hua Q.	Bioresour Bioprocess	10.1186/s40643-022-00583-7	2022
	Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii.	Nie LB, Liang QL, Du R, Elsheikha HM, Han NJ, Li FC, Zhu XQ.	Front Microbiol	10.3389/fmicb.2020.00776	2020
Genetics	Saccharopolyspora erythraea's genome is organised in high-order transcriptional regions mediated by targeted degradation at the metabolic switch.	Marcellin E, Mercer TR, Licona-Cassani C, Palfreyman RW, Dinger ME, Steen JA, Mattick JS, Nielsen LK.	BMC Genomics	10.1186/1471-2164-14-15	2013
Metabolism	Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea.	Wu H, Chen M, Mao Y, Li W, Liu J, Huang X, Zhou Y, Ye BC, Zhang L, Weaver DT, Zhang B.	Microb Cell Fact	10.1186/s12934-014-0158-4	2014
Metabolism	Temporal dynamics of the Saccharopolyspora erythraea phosphoproteome.	Licona-Cassani C, Lim S, Marcellin E, Nielsen LK.	Mol Cell Proteomics	10.1074/mcp.m113.033951	2014
	Improved production of erythromycin by Saccharopolyspora erythraea by various plant oils	Hamedi J, Malekzadeh F, Niknam V.	Biotechnol Lett	10.1023/a:1015282016388	2002
Metabolism	Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase.	Ward SL, Desai RP, Hu Z, Gramajo H, Katz L.	J Ind Microbiol Biotechnol	10.1007/s10295-006-0156-6	2007
Enzymology	Isolation and structure of a new macrolide antibiotic, erythromycin G, and a related biosynthetic intermediate from a culture of Saccharopolyspora erythraea.	Cevallos A, Guerriero A.	J Antibiot (Tokyo)	10.7164/antibiotics.56.280	2003
Metabolism	Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea.	Weissman KJ, Hong H, Oliynyk M, Siskos AP, Leadlay PF.	Chembiochem	10.1002/cbic.200300775	2004
Metabolism	Release of Soybean Isoflavones by Using a beta-Glucosidase from Alicyclobacillus herbarius.	Delgado L, Heckmann CM, Di Pisa F, Gourlay L, Paradisi F.	Chembiochem	10.1002/cbic.202000688	2021
	Guidelines for metabolomics-guided transposon mutagenesis for microbial natural product discovery.	Covington BC, Seyedsayamdost MR.	Methods Enzymol	10.1016/bs.mie.2021.11.020	2022
	Regulatory Patterns of Crp on Monensin Biosynthesis in Streptomyces cinnamonensis.	Lin CY, Zhang Y, Wu JH, Xie RH, Qiao J, Zhao GR.	Microorganisms	10.3390/microorganisms8020271	2020
Enzymology	A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases.	Hu Z, Pfeifer BA, Chao E, Murli S, Kealey J, Carney JR, Ashley G, Khosla C, Hutchinson CR.	Microbiology (Reading)	10.1099/mic.0.26015-0	2003
Metabolism	Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tü57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1.	Weitnauer G, Gaisser S, Kellenberger L, Leadlay PF, Bechthold A.	Microbiology (Reading)	10.1099/00221287-148-2-373	2002
Pathogenicity	Engineering of the spinosyn PKS: directing starter unit incorporation.	Sheehan LS, Lill RE, Wilkinson B, Sheridan RM, Vousden WA, Kaja AL, Crouse GD, Gifford J, Graupner PR, Karr L, Lewer P, Sparks TC, Leadlay PF, Waldron C, Martin CJ.	J Nat Prod	10.1021/np0602517	2006
Metabolism	Subtilisin-Involved Morphology Engineering for Improved Antibiotic Production in Actinomycetes.	Wu Y, Kang Q, Zhang LL, Bai L.	Biomolecules	10.3390/biom10060851	2020
	Viability, strength, and fragmentation of Saccharopolyspora erythraea in submerged fermentation.	Stocks SM, Thomas CR.	Biotechnol Bioeng	10.1002/bit.10017	2001
Metabolism	Nitrogen regulator GlnR controls uptake and utilization of non-phosphotransferase-system carbon sources in actinomycetes.	Liao CH, Yao L, Xu Y, Liu WB, Zhou Y, Ye BC.	Proc Natl Acad Sci U S A	10.1073/pnas.1508465112	2015
Metabolism	Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation.	Hong JS, Park SJ, Parajuli N, Park SR, Koh HS, Jung WS, Choi CY, Yoon YJ.	Gene	10.1016/j.gene.2006.08.021	2007
Metabolism	Precursor-directed production of erythromycin analogs by Saccharopolyspora erythraea.	Frykman S, Leaf T, Carreras C, Licari P.	Biotechnol Bioeng	10.1002/bit.10086	2001
Metabolism	Dissolution of the Disparate: Co-ordinate Regulation in Antibiotic Biosynthesis.	McLean TC, Wilkinson B, Hutchings MI, Devine R.	Antibiotics (Basel)	10.3390/antibiotics8020083	2019
Metabolism	Identification and cloning of a type III polyketide synthase required for diffusible pigment biosynthesis in Saccharopolyspora erythraea.	Cortes J, Velasco J, Foster G, Blackaby AP, Rudd BA, Wilkinson B.	Mol Microbiol	10.1046/j.1365-2958.2002.02975.x	2002
	The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope bridge for phospholipid trafficking.	Grasekamp KP, Beaud Benyahia B, Taib N, Audrain B, Bardiaux B, Rossez Y, Izadi-Pruneyre N, Lejeune M, Trivelli X, Chouit Z, Guerardel Y, Ghigo JM, Gribaldo S, Beloin C.	Nat Commun	10.1038/s41467-023-43411-y	2023
Metabolism	Intelligent modelling of bioprocesses: a comparison of structured and unstructured approaches.	Hodgson BJ, Taylor CN, Ushio M, Leigh JR, Kalganova T, Baganz F.	Bioprocess Biosyst Eng	10.1007/s00449-004-0382-0	2004
Metabolism	Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins.	Carreras C, Frykman S, Ou S, Cadapan L, Zavala S, Woo E, Leaf T, Carney J, Burlingame M, Patel S, Ashley G, Licari P.	J Biotechnol	10.1016/s0168-1656(01)00372-8	2002
Metabolism	Analysis of genes involved in 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraea.	Doumith M, Weingarten P, Wehmeier UF, Salah-Bey K, Benhamou B, Capdevila C, Michel JM, Piepersberg W, Raynal MC.	Mol Gen Genet	10.1007/s004380000329	2000
Metabolism	Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea.	Gaisser S, Lill R, Staunton J, Mendez C, Salas J, Leadlay PF.	Mol Microbiol	10.1046/j.1365-2958.2002.02910.x	2002
Genetics	Bioactive Metabolites from Terrestrial and Marine Actinomycetes.	Ngamcharungchit C, Chaimusik N, Panbangred W, Euanorasetr J, Intra B.	Molecules	10.3390/molecules28155915	2023
Metabolism	Improvement of macrolactins production by the genetic adaptation of Bacillus siamensis A72 to saline stress via adaptive laboratory evolution.	Gan Y, Bai M, Lin X, Liu K, Huang B, Jiang X, Liu Y, Gao C.	Microb Cell Fact	10.1186/s12934-022-01871-9	2022
Metabolism	Strength of mid-logarithmic and stationary phase Saccharopolyspora erythraea hyphae during a batch fermentation in defined nitrate-limited medium.	Stocks SM, Thomas CR.	Biotechnol Bioeng	10.1002/bit.1070	2001
Metabolism	New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster.	Gaisser S, Lill R, Wirtz G, Grolle F, Staunton J, Leadlay PF.	Mol Microbiol	10.1046/j.1365-2958.2001.02594.x	2001
Metabolism	Morphology engineering of Streptomyces coelicolor M145 by sub-inhibitory concentrations of antibiotics.	Wang H, Zhao G, Ding X.	Sci Rep	10.1038/s41598-017-13493-y	2017
Metabolism	Chitinolytic functions in actinobacteria: ecology, enzymes, and evolution.	Lacombe-Harvey ME, Brzezinski R, Beaulieu C.	Appl Microbiol Biotechnol	10.1007/s00253-018-9149-4	2018
	Dodecin as carrier protein for immunizations and bioengineering applications.	Bourdeaux F, Kopp Y, Lautenschlager J, Gossner I, Besir H, Vabulas RM, Grininger M.	Sci Rep	10.1038/s41598-020-69990-0	2020
Metabolism	Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.	Volchegursky Y, Hu Z, Katz L, McDaniel R.	Mol Microbiol	10.1046/j.1365-2958.2000.02059.x	2000
Metabolism	Droplet-based microfluidic platform for high-throughput screening of Streptomyces.	Tu R, Zhang Y, Hua E, Bai L, Huang H, Yun K, Wang M.	Commun Biol	10.1038/s42003-021-02186-y	2021
Metabolism	Engineering intracellular malonyl-CoA availability in microbial hosts and its impact on polyketide and fatty acid synthesis.	Milke L, Marienhagen J.	Appl Microbiol Biotechnol	10.1007/s00253-020-10643-7	2020
Metabolism	Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli.	Lau J, Tran C, Licari P, Galazzo J.	J Biotechnol	10.1016/j.jbiotec.2004.02.001	2004
Metabolism	Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays.	Lum AM, Huang J, Hutchinson CR, Kao CM.	Metab Eng	10.1016/j.ymben.2003.12.001	2004
	Molecular docking of azole drugs and their analogs on CYP121 of Mycobacterium tuberculosis.	Sundaramurthi JC, Kumar S, Silambuchelvi K, Hanna LE.	Bioinformation	10.6026/97320630007130	2011
Metabolism	Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.	Kawasaki T, Hirashima R, Maruta T, Sato H, Maeda A, Yamada Y, Takeda M, Hayakawa Y.	Appl Environ Microbiol	10.1128/aem.00668-10	2010
	The erythromycin biosynthetic gene cluster of Aeromicrobium erythreum.	Brikun IA, Reeves AR, Cernota WH, Luu MB, Weber JM.	J Ind Microbiol Biotechnol	10.1007/s10295-004-0154-5	2004
	Trends in Helicobacter pylori resistance to clarithromycin: from phenotypic to genomic approaches.	Marques AT, Vitor JMB, Santos A, Oleastro M, Vale FF.	Microb Genom	10.1099/mgen.0.000344	2020
	The Effect of Rapeseed Oil Uptake on the Production of Erythromycin and Triketide Lactone by Saccharopolyspora erythraea.	Mirjalili N, Zormpaidis V, Leadlay PF, Ison AP.	Biotechnol Prog	10.1021/bp990099h	1999
	Semi-constant-time HMSQC (SCT-HMSQC-HA) for the measurement of (3)J(H(N))(H(alpha)) couplings in (15)N-labeled proteins.	Aitio H, Permi P.	J Magn Reson	10.1006/jmre.1999.2010	2000
Metabolism	Staphylococcus aureus modulates the activity of acetyl-Coenzyme A synthetase (Acs) by sirtuin-dependent reversible lysine acetylation.	Burckhardt RM, Buckner BA, Escalante-Semerena JC.	Mol Microbiol	10.1111/mmi.14276	2019
Metabolism	A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea.	Gaisser S, Reather J, Wirtz G, Kellenberger L, Staunton J, Leadlay PF.	Mol Microbiol	10.1046/j.1365-2958.2000.01856.x	2000
Enzymology	Active-site residue, domain and module swaps in modular polyketide synthases.	Del Vecchio F, Petkovic H, Kendrew SG, Low L, Wilkinson B, Lill R, Cortes J, Rudd BA, Staunton J, Leadlay PF.	J Ind Microbiol Biotechnol	10.1007/s10295-003-0062-0	2003
Metabolism	Mechanisms, Detection, and Relevance of Protein Acetylation in Prokaryotes.	Christensen DG, Baumgartner JT, Xie X, Jew KM, Basisty N, Schilling B, Kuhn ML, Wolfe AJ.	mBio	10.1128/mbio.02708-18	2019
Metabolism	Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.	Skiba MA, Tran CL, Dan Q, Sikkema AP, Klaver Z, Gerwick WH, Sherman DH, Smith JL.	Structure	10.1016/j.str.2019.11.004	2020
Metabolism	In vitro reconstruction of tetronate RK-682 biosynthesis.	Sun Y, Hahn F, Demydchuk Y, Chettle J, Tosin M, Osada H, Leadlay PF.	Nat Chem Biol	10.1038/nchembio.285	2010
Metabolism	Proteome-wide profiling of protein lysine acetylation in Aspergillus flavus.	Lv Y.	PLoS One	10.1371/journal.pone.0178603	2017
Metabolism	Studies on the interaction of fermentation and microfiltration operations: erythromycin recovery from Saccharopolyspora erythraea fermentation broths.	Davies JL, Baganz F, Ison AP, Lye GJ.	Biotechnol Bioeng	10.1002/1097-0290(20000820)69:4<429::aid-bit9>3.0.co;2-5	2000
Metabolism	A genetically engineered strain of Saccharopolyspora erythraea that produces 6,12-dideoxyerythromycin A as the major fermentation product.	Stassi D, Post D, Satter M, Jackson M, Maine G.	Appl Microbiol Biotechnol	10.1007/s002530051238	1998
Metabolism	Engineered biosynthesis of novel spinosyns bearing altered deoxyhexose substituents.	Gaisser S, Martin CJ, Wilkinson B, Sheridan RM, Lill RE, Weston AJ, Ready SJ, Waldron C, Crouse GD, Leadlay PF, Staunton J.	Chem Commun (Camb)	10.1039/b200536k	2002
Metabolism	Interspecies complementation in Saccharopolyspora erythraea : elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives.	Doumith M, Legrand R, Lang C, Salas JA, Raynal MC.	Mol Microbiol	10.1046/j.1365-2958.1999.01666.x	1999
Metabolism	The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis.	Hou B, Lin Y, Wu H, Guo M, Petkovic H, Tao L, Zhu X, Ye J, Zhang H.	J Bacteriol	10.1128/jb.00447-17	2018
	Reactor heterogeneity with saccharopolyspora erythraea airlift fermentations	Pollard DJ, Ison AP, Shamlou PA, Lilly MD.	Biotechnol Bioeng	10.1002/(sici)1097-0290(19980605)58:5<453::aid-bit1>3.0.co;2-c	1998
Pathogenicity	[Isolation and characterization of Saccharopolyspora erythraea mutants, resistant to chloramphenicol].	Nastasiak IN, Zavorotnaia SA, Fedorenko VA, Danilenko VN.	Antibiot Khimioter		1999
	Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea.	Salah-Bey K, Doumith M, Michel JM, Haydock S, Cortes J, Leadlay PF, Raynal MC.	Mol Gen Genet	10.1007/s004380050680	1998
	Improved erythromycin production in a genetically engineered industrial strain of Saccharopolyspora erythraea.	Minas W, Brunker P, Kallio PT, Bailey JE.	Biotechnol Prog	10.1021/bp980055t	1998
Metabolism	Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains.	Rodriguez E, Hu Z, Ou S, Volchegursky Y, Hutchinson CR, McDaniel R.	J Ind Microbiol Biotechnol	10.1007/s10295-003-0045-1	2003
Metabolism	Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes.	Tanaka Y, Komatsu M, Okamoto S, Tokuyama S, Kaji A, Ikeda H, Ochi K.	Appl Environ Microbiol	10.1128/aem.00681-09	2009
	Nucleotide sequence of the ermE distal flank of the erythromycin biosynthesis cluster in Saccharopolyspora erythraea.	Pereda A, Summers R, Katz L.	Gene	10.1016/s0378-1119(97)00086-3	1997
	[Localization of rifampicin resistance determinants on genetic map of Saccharopolyspora erythraea].	Nastasyak IN.	Antibiot Khimioter		1997
Enzymology	Streptomycetes: Attractive Hosts for Recombinant Protein Production.	Berini F, Marinelli F, Binda E.	Front Microbiol	10.3389/fmicb.2020.01958	2020
	Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica.	Rego A, Sousa AGG, Santos JP, Pascoal F, Canario J, Leao PN, Magalhaes C.	Microorganisms	10.3390/microorganisms8020279	2020
Metabolism	Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2.	Glaser L, Kuhl M, Stegmuller J, Ruckert C, Myronovskyi M, Kalinowski J, Luzhetskyy A, Wittmann C.	Microb Cell Fact	10.1186/s12934-021-01602-6	2021
	Protein acetylation-mediated cross regulation of acetic acid and ethanol synthesis in the gas-fermenting Clostridium ljungdahlii.	Liu Y, Zhang Z, Jiang W, Gu Y.	J Biol Chem	10.1016/j.jbc.2021.101538	2022
	Genetic engineering of an industrial strain of Saccharopolyspora erythraea for stable expression of the Vitreoscilla haemoglobin gene (vhb).	Brunker P, Minas W, Kallio PT, Baile JE.	Microbiology (Reading)	10.1099/00221287-144-9-2441	1998
Metabolism	Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.	Gaisser S, Bohm GA, Doumith M, Raynal MC, Dhillon N, Cortes J, Leadlay PF.	Mol Gen Genet	10.1007/s004380050709	1998
	Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea.	Gaisser S, Bohm GA, Cortes J, Leadlay PF.	Mol Gen Genet	10.1007/s004380050566	1997
	Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B.	Kato Y, Bai L, Xue Q, Revill WP, Yu TW, Floss HG.	J Am Chem Soc	10.1021/ja0127483	2002
Metabolism	Evaluation of vector systems and promoters for overexpression of the acarbose biosynthesis gene acbC in Actinoplanes sp. SE50/110.	Schaffert L, Marz C, Burkhardt L, Droste J, Brandt D, Busche T, Rosen W, Schneiker-Bekel S, Persicke M, Puhler A, Kalinowski J.	Microb Cell Fact	10.1186/s12934-019-1162-5	2019
Enzymology	[The isolation and characteristics of mutants of the Saccharopolyspora erythraea strain resistant to thiostrepton].	Nastasiak IN, Fedorenko VA, Danilenko VN.	Antibiot Khimioter		1997
Metabolism	Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism.	Amara A, Takano E, Breitling R.	BMC Genomics	10.1186/s12864-018-4905-5	2018
	Increasing the efficiency of heterologous promoters in actinomycetes.	Wilkinson CJ, Hughes-Thomas ZA, Martin CJ, Bohm I, Mironenko T, Deacon M, Wheatcroft M, Wirtz G, Staunton J, Leadlay PF.	J Mol Microbiol Biotechnol		2002
Metabolism	Molecular and Biochemical Characterization of a Type II Thioesterase From the Zoonotic Protozoan Parasite Cryptosporidium parvum.	Guo F, Zhang H, Eltahan R, Zhu G.	Front Cell Infect Microbiol	10.3389/fcimb.2019.00199	2019
Metabolism	Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea.	Hessler PE, Larsen PE, Constantinou AI, Schram KH, Weber JM.	Appl Microbiol Biotechnol	10.1007/s002530050947	1997
	Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead.	Bauman KD, Shende VV, Chen PY, Trivella DBB, Gulder TAM, Vellalath S, Romo D, Moore BS.	Nat Chem Biol	10.1038/s41589-022-00993-w	2022
Metabolism	The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea.	Pereda A, Summers RG, Stassi DL, Ruan X, Katz L.	Microbiology (Reading)	10.1099/00221287-144-2-543	1998
	Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.	Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C.	Science	10.1126/science.1058092	2001
Genetics	Chromosome topology and genome size of selected actinomycetes species.	Redenbach M, Scheel J, Schmidt U.	Antonie Van Leeuwenhoek	10.1023/a:1010289326752	2000
Metabolism	Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination.	Wu J, Zhang Q, Deng W, Qian J, Zhang S, Liu W.	Appl Environ Microbiol	10.1128/aem.06034-11	2011
	Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis.	Klopries S, Bravo-Rodriguez K, Koopmans KR, Sundermann U, Yahiaoui S, Arens J, Kushnir S, Sanchez-Garcia E, Schulz F.	Data Brief	10.1016/j.dib.2015.09.052	2015
	Effects of Nanopillar Size and Spacing on Mechanical Perturbation and Bactericidal Killing Efficiency.	Velic A, Jaggessar A, Tesfamichael T, Li Z, Yarlagadda PKDV.	Nanomaterials (Basel)	10.3390/nano11102472	2021
Metabolism	Comparative metabolomics analysis of amphotericin B high-yield mechanism for metabolic engineering.	Zhang B, Chen Y, Jiang SX, Cai X, Huang K, Liu ZQ, Zheng YG.	Microb Cell Fact	10.1186/s12934-021-01552-z	2021
Metabolism	Stereochemistry of catalysis by the ketoreductase activity in the first extension module of the erythromycin polyketide synthase.	Ostergaard LH, Kellenberger L, Cortes J, Roddis MP, Deacon M, Staunton J, Leadlay PF.	Biochemistry	10.1021/bi0117605	2002
	Novel macrolides through genetic engineering.	Katz L, McDaniel R.	Med Res Rev	10.1002/(sici)1098-1128(199911)19:6<543::aid-med5>3.0.co;2-z	1999
	Assessing similarities and disparities in the skin microbiota between wild and laboratory populations of house mice.	Belheouane M, Vallier M, Cepic A, Chung CJ, Ibrahim S, Baines JF.	ISME J	10.1038/s41396-020-0690-7	2020
Metabolism	New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway.	Malmierca MG, Perez-Victoria I, Martin J, Reyes F, Mendez C, Salas JA, Olano C.	Appl Environ Microbiol	10.1128/aem.02453-19	2020
Metabolism	AccR, a TetR Family Transcriptional Repressor, Coordinates Short-Chain Acyl Coenzyme A Homeostasis in Streptomyces avermitilis.	Lyu M, Cheng Y, Han X, Wen Y, Song Y, Li J, Chen Z.	Appl Environ Microbiol	10.1128/aem.00508-20	2020
	NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo)trypsin-like serine fold proteases.	Denesyuk AI, Johnson MS, Salo-Ahen OMH, Uversky VN, Denessiouk K.	Int J Biol Macromol	10.1016/j.ijbiomac.2020.03.025	2020
	Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus.	Zdouc MM, Iorio M, Maffioli SI, Crusemann M, Donadio S, Sosio M.	J Nat Prod	10.1021/acs.jnatprod.0c00807	2021
Metabolism	Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.	Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.	Microbiology (Reading)	10.1099/00221287-143-10-3251	1997
Metabolism	Erythromycin production in Saccharopolyspora erythraea does not require a functional propionyl-CoA carboxylase.	Donadio S, Staver MJ, Katz L.	Mol Microbiol	10.1046/j.1365-2958.1996.439969.x	1996
	The use of PCR to isolate a putative ABC transporter from Saccharopolyspora erythraea.	O'Neill MP, Eady EA, Radford A, Baumberg S, Cove JH.	FEMS Microbiol Lett	10.1111/j.1574-6968.1995.tb07776.x	1995
Metabolism	SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.	Kirm B, Magdevska V, Tome M, Horvat M, Karnicar K, Petek M, Vidmar R, Baebler S, Jamnik P, Fujs S, Horvat J, Fonovic M, Turk B, Gruden K, Petkovic H, Kosec G.	Microb Cell Fact	10.1186/1475-2859-12-126	2013
	Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin.	Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R.	J Antibiot (Tokyo)	10.7164/antibiotics.53.502	2000
Metabolism	A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea.	Chng C, Lum AM, Vroom JA, Kao CM.	Proc Natl Acad Sci U S A	10.1073/pnas.0803622105	2008
Enzymology	Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase.	Rowe CJ, Bohm IU, Thomas IP, Wilkinson B, Rudd BA, Foster G, Blackaby AP, Sidebottom PJ, Roddis Y, Buss AD, Staunton J, Leadlay PF.	Chem Biol	10.1016/s1074-5521(01)00024-2	2001
	Cloning and heterologous expression of the genes encoding nonspecific electron transport components for a cytochrome P450 system of Saccharopolyspora erythraea involved in erythromycin production.	Zotchev SB, Hutchinson CR.	Gene	10.1016/0378-1119(95)00012-u	1995
Enzymology	Acetylation of Lactate Dehydrogenase Negatively Regulates the Acidogenicity of Streptococcus mutans.	Ma Q, Pan Y, Chen Y, Yu S, Huang J, Liu Y, Gong T, Zhang Q, Sun Q, Zou J, Li Y.	mBio	10.1128/mbio.02013-22	2022
Enzymology	Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum.	Wilkinson CJ, Frost EJ, Staunton J, Leadlay PF.	Chem Biol	10.1016/s1074-5521(01)00087-4	2001
Pathogenicity	Dispensable ribosomal resistance to spiramycin conferred by srmA in the spiramycin producer Streptomyces ambofaciens.	Pernodet JL, Gourmelen A, Blondelet-Rouault MH, Cundliffe E.	Microbiology (Reading)	10.1099/00221287-145-9-2355	1999
Metabolism	Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699.	Doi-Katayama Y, Yoon YJ, Choi CY, Yu TW, Floss HG, Hutchinson CR.	J Antibiot (Tokyo)	10.7164/antibiotics.53.484	2000
	Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2'-bipyridine formation.	Pang B, Liao R, Tang Z, Guo S, Wu Z, Liu W.	Nat Commun	10.1038/s41467-021-23475-4	2021
Metabolism	Lysine acetylation of the housekeeping sigma factor enhances the activity of the RNA polymerase holoenzyme.	Kim JE, Choi JS, Kim JS, Cho YH, Roe JH.	Nucleic Acids Res	10.1093/nar/gkaa011	2020
	Enhancement of precursor amino acid supplies for improving bacitracin production by activation of branched chain amino acid transporter BrnQ and deletion of its regulator gene lrp in Bacillus licheniformis.	Zhu J, Cai D, Xu H, Liu Z, Zhang B, Wu F, Li J, Chen S.	Synth Syst Biotechnol	10.1016/j.synbio.2018.10.009	2018
	Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2).	Rodri Guez E, Gramajo H.	Microbiology (Reading)	10.1099/00221287-145-11-3109	1999
Metabolism	Improving phytosterol biotransformation at low nitrogen levels by enhancing the methylcitrate cycle with transcriptional regulators PrpR and GlnR of Mycobacterium neoaurum.	Zhang Y, Zhou X, Wang X, Wang L, Xia M, Luo J, Shen Y, Wang M.	Microb Cell Fact	10.1186/s12934-020-1285-8	2020
Metabolism	Cloning of the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraea.	Linton KJ, Jarvis BW, Hutchinson CR.	Gene	10.1016/0378-1119(94)00809-7	1995
	Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.	Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukezic T, Bernecker S, Huttel S, Jansen R, Schmiedel J, Fritzenwanker M, Imirzalioglu C, Vogel J, Westermann AJ, Hesterkamp T, Stadler M, Wagenlehner F, Petkovic H, Herrmann J, Muller R.	Antibiotics (Basel)	10.3390/antibiotics9090619	2020
Pathogenicity	A genome-wide analysis of targets of macrolide antibiotics in mammalian cells.	Gupta A, Okesli-Armlovich A, Morgens D, Bassik MC, Khosla C.	J Biol Chem	10.1074/jbc.ra119.010770	2020
Metabolism	Estimation of the kinetic constants and elucidation of trends in growth and erythromycin production in batch and continuous cultures of Saccharopolyspora erythraea using curve-fitting techniques.	McDermott JF, Lethbridge G, Bushell ME.	Enzyme Microb Technol	10.1016/0141-0229(93)90065-a	1993
	Plausible Minimal Substrate for Erm Protein.	Lee HJ, Park YI, Jin HJ.	Antimicrob Agents Chemother	10.1128/aac.00023-20	2020
	Production of poly-beta-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces.	van Dissel D, Willemse J, Zacchetti B, Claessen D, Pier GB, van Wezel GP.	Microb Cell	10.15698/mic2018.06.635	2018
	Engineering of leucine-responsive regulatory protein improves spiramycin and bitespiramycin biosynthesis.	Lu Z, Zhang X, Dai J, Wang Y, He W.	Microb Cell Fact	10.1186/s12934-019-1086-0	2019
Metabolism	Engineering broader specificity into an antibiotic-producing polyketide synthase.	Marsden AF, Wilkinson B, Cortes J, Dunster NJ, Staunton J, Leadlay PF.	Science	10.1126/science.279.5348.199	1998
Metabolism	Suitable extracellular oxidoreduction potential inhibit rex regulation and effect central carbon and energy metabolism in Saccharopolyspora spinosa.	Zhang X, Xue C, Zhao F, Li D, Yin J, Zhang C, Caiyin Q, Lu W.	Microb Cell Fact	10.1186/s12934-014-0098-z	2014
	IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea.	Donadio S, Staver MJ.	Gene	10.1016/0378-1119(93)90604-2	1993
	Synergy Pattern of Short Cationic Antimicrobial Peptides Against Multidrug-Resistant Pseudomonas aeruginosa.	Ruden S, Rieder A, Chis Ster I, Schwartz T, Mikut R, Hilpert K.	Front Microbiol	10.3389/fmicb.2019.02740	2019
	A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters.	Covington BC, Xu F, Seyedsayamdost MR.	Annu Rev Biochem	10.1146/annurev-biochem-081420-102432	2021
	[Isolation and characterization of genetic recombinants in protoplast fusion in Saccharopolyspora erythraea].	Kirichenko NV, Nastasiak IN, Basiliia LI, Fedorenko VA, Danilenko VN.	Antibiot Khimioter		1993
Enzymology	The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome-binding site.	Bibb MJ, White J, Ward JM, Janssen GR.	Mol Microbiol	10.1111/j.1365-2958.1994.tb02187.x	1994
	Exploring the Promise of Endophytic Fungi: A Review of Novel Antimicrobial Compounds.	Caruso DJ, Palombo EA, Moulton SE, Zaferanloo B.	Microorganisms	10.3390/microorganisms10101990	2022
	Cloning and expression of the N-acetylmuramidase gene from Streptomyces rutgersensis H-46.	Shimonishi T, Nirasawa S, Hayashi K.	J Biosci Bioeng	10.1016/s1389-1723(99)80211-4	1999
Metabolism	ErmE methyltransferase recognizes features of the primary and secondary structure in a motif within domain V of 23 S rRNA.	Villsen ID, Vester B, Douthwaite S.	J Mol Biol	10.1006/jmbi.1998.2504	1999
	Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.	Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, Cooper DJ, Dawson MJ, Buss AD, Gaisser S, Bohm IU, Rowe CJ, Cortes J, Leadlay PF, Staunton J.	Chem Biol	10.1016/s1074-5521(00)00076-4	2000
Metabolism	Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters.	Schorn MA, Alanjary MM, Aguinaldo K, Korobeynikov A, Podell S, Patin N, Lincecum T, Jensen PR, Ziemert N, Moore BS.	Microbiology (Reading)	10.1099/mic.0.000386	2016
Enzymology	Purification of a thymidine-diphospho-4-keto-6-deoxy-D-glucose epimerase from an erythromycin-producing strain of Saccharopolyspora erythraea.	Jarvis BW, Hutchinson CR.	Arch Biochem Biophys	10.1006/abbi.1994.1025	1994
Metabolism	Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK.	Lambalot RH, Cane DE, Aparicio JJ, Katz L.	Biochemistry	10.1021/bi00006a006	1995
Metabolism	Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation.	Chen Y, Deng W, Wu J, Qian J, Chu J, Zhuang Y, Zhang S, Liu W.	Appl Environ Microbiol	10.1128/aem.02770-07	2008
Enzymology	Construction of new vectors for high-level expression in actinomycetes.	Rowe CJ, Cortes J, Gaisser S, Staunton J, Leadlay PF.	Gene	10.1016/s0378-1119(98)00327-8	1998
Metabolism	[Metabolism of alpha-ketoacids in erythromycin biosynthesis in various strains of Saccharopolyspora erythraea].	Bulgakova VG, Grushina VA, Orlova TI, Petrykina ZM, Polin AN, Mironov VA, Danilenko VN.	Antibiot Khimioter		1993
	From Erythromycin to Azithromycin and New Potential Ribosome-Binding Antimicrobials.	Jelic D, Antolovic R.	Antibiotics (Basel)	10.3390/antibiotics5030029	2016
	Advances in actinomycete research: an ActinoBase review of 2019.	Prudence SMM, Addington E, Castano-Espriu L, Mark DR, Pintor-Escobar L, Russell AH, McLean TC.	Microbiology (Reading)	10.1099/mic.0.000944	2020
Metabolism	ErmE methyltransferase recognition elements in RNA substrates.	Vester B, Nielsen AK, Hansen LH, Douthwaite S.	J Mol Biol	10.1006/jmbi.1998.2024	1998
	Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension.	Bohm I, Holzbaur IE, Hanefeld U, Cortes J, Staunton J, Leadlay PF.	Chem Biol	10.1016/s1074-5521(98)90157-0	1998
	Mechanics of Bacterial Interaction and Death on Nanopatterned Surfaces.	Velic A, Hasan J, Li Z, Yarlagadda PKDV.	Biophys J	10.1016/j.bpj.2020.12.003	2021
Metabolism	Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.	Lozano MJ, Remsing LL, Quiros LM, Brana AF, Fernandez E, Sanchez C, Mendez C, Rohr J, Salas JA.	J Biol Chem	10.1074/jbc.275.5.3065	2000
	Chromosomal position effect influences the heterologous expression of genes and biosynthetic gene clusters in Streptomyces albus J1074.	Bilyk B, Horbal L, Luzhetskyy A.	Microb Cell Fact	10.1186/s12934-016-0619-z	2017
	Characterization of the genes and attachment sites for site-specific integration of plasmid pSE101 in Saccharopolyspora erythraea and Streptomyces lividans.	Brown DP, Idler KB, Backer DM, Donadio S, Katz L.	Mol Gen Genet	10.1007/bf00391012	1994
Metabolism	A Phenotypic and Genotypic Analysis of the Antimicrobial Potential of Cultivable Streptomyces Isolated from Cave Moonmilk Deposits.	Maciejewska M, Adam D, Martinet L, Naome A, Calusinska M, Delfosse P, Carnol M, Barton HA, Hayette MP, Smargiasso N, De Pauw E, Hanikenne M, Baurain D, Rigali S.	Front Microbiol	10.3389/fmicb.2016.01455	2016
Genetics	Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction.	Wang R, Kong F, Wu H, Hou B, Kang Y, Cao Y, Duan S, Ye J, Zhang H.	Synth Syst Biotechnol	10.1016/j.synbio.2020.03.001	2020
Pathogenicity	EGTA induces the synthesis in Escherichia coli of three proteins that cross-react with calmodulin antibodies.	Laoudj D, Andersen CL, Bras A, Goldberg M, Jacq A, Holland IB.	Mol Microbiol	10.1111/j.1365-2958.1994.tb00439.x	1994
Genetics	Metagenomic Composition Analysis of an Ancient Sequenced Polar Bear Jawbone from Svalbard.	Pratas D, Hosseini M, Grilo G, Pinho AJ, Silva RM, Caetano T, Carneiro J, Pereira F.	Genes (Basel)	10.3390/genes9090445	2018
Metabolism	Prokaryotic calcium-binding protein of the calmodulin superfamily. Calcium binding to a Saccharopolyspora erythraea 20 kDa protein.	Bylsma N, Drakenberg T, Andersson I, Leadlay PF, Forsen S.	FEBS Lett	10.1016/0014-5793(92)80096-y	1992
Metabolism	Systematic analysis of the lysine malonylome in common wheat.	Liu J, Wang G, Lin Q, Liang W, Gao Z, Mu P, Li G, Song L.	BMC Genomics	10.1186/s12864-018-4535-y	2018
	Crystallization and preliminary X-ray diffraction studies of the calcium-binding protein CalD from Streptomyces coelicolor.	Zhao X, Wang S, Pang H, Yang K, Bartlam M.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309108019891	2008
	Quantification of N-acetylcysteamine activated methylmalonate incorporation into polyketide biosynthesis.	Klopries S, Sundermann U, Schulz F.	Beilstein J Org Chem	10.3762/bjoc.9.75	2013
Pathogenicity	Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.	Woodhead JL, Yang K, Oldach D, MacLauchlin C, Fernandes P, Watkins PB, Siler SQ, Howell BA.	Pharm Res	10.1007/s11095-019-2582-y	2019
Metabolism	Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.	Pfeifer B, Hu Z, Licari P, Khosla C.	Appl Environ Microbiol	10.1128/aem.68.7.3287-3292.2002	2002
Metabolism	The physiology of erythromycin biosynthesis in cyclic fed batch culture.	Lynch HC, Bushell ME.	Microbiology (Reading)	10.1099/13500872-141-12-3105	1995
	Polyketide stereocontrol: a study in chemical biology.	Weissman KJ.	Beilstein J Org Chem	10.3762/bjoc.13.39	2017
	An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea.	Weber JM, Leung JO, Swanson SJ, Idler KB, McAlpine JB.	Science	10.1126/science.2011746	1991
Metabolism	Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.	Lowell AN, DeMars MD, Slocum ST, Yu F, Anand K, Chemler JA, Korakavi N, Priessnitz JK, Park SR, Koch AA, Schultz PJ, Sherman DH.	J Am Chem Soc	10.1021/jacs.7b02875	2017
Enzymology	Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea.	Caffrey P, Bevitt DJ, Staunton J, Leadlay PF.	FEBS Lett	10.1016/0014-5793(92)80624-p	1992
Genetics	Genome-scale model guided design of Propionibacterium for enhanced propionic acid production.	Navone L, McCubbin T, Gonzalez-Garcia RA, Nielsen LK, Marcellin E.	Metab Eng Commun	10.1016/j.meteno.2017.11.001	2018
	The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase.	Weissman KJ, Timoney M, Bycroft M, Grice P, Hanefeld U, Staunton J, Leadlay PF.	Biochemistry	10.1021/bi971566b	1997
	LmbU, a Cluster-Situated Regulator for Lincomycin, Consists of a DNA-Binding Domain, an Auto-Inhibitory Domain, and Forms Homodimer.	Hou B, Zhu X, Kang Y, Wang R, Wu H, Ye J, Zhang H.	Front Microbiol	10.3389/fmicb.2019.00989	2019
Metabolism	CabC, an EF-hand calcium-binding protein, is involved in Ca2+-mediated regulation of spore germination and aerial hypha formation in Streptomyces coelicolor.	Wang SL, Fan KQ, Yang X, Lin ZX, Xu XP, Yang KQ.	J Bacteriol	10.1128/jb.01954-07	2008
	Cloning and characterization of the Saccharopolyspora erythraea fdxA gene encoding ferredoxin.	Donadio S, Hutchinson CR.	Gene	10.1016/0378-1119(91)90372-i	1991
	A hybrid modular polyketide synthase obtained by domain swapping.	Oliynyk M, Brown MJ, Cortes J, Staunton J, Leadlay PF.	Chem Biol	10.1016/s1074-5521(96)90069-1	1996
Enzymology	Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea.	Donadio S, Katz L.	Gene	10.1016/0378-1119(92)90602-l	1992
Enzymology	An acyl-carrier-protein-thioesterase domain from the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-level production, purification and characterisation in Escherichia coli.	Caffrey P, Green B, Packman LC, Rawlings BJ, Staunton J, Leadlay PF.	Eur J Biochem	10.1111/j.1432-1033.1991.tb15771.x	1991
	ClusterMine360: a database of microbial PKS/NRPS biosynthesis.	Conway KR, Boddy CN.	Nucleic Acids Res	10.1093/nar/gks993	2013
	Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production.	Sulheim S, Kumelj T, van Dissel D, Salehzadeh-Yazdi A, Du C, van Wezel GP, Nieselt K, Almaas E, Wentzel A, Kerkhoven EJ.	iScience	10.1016/j.isci.2020.101525	2020
Metabolism	Site-specific and kinetic characterization of enzymatic and nonenzymatic protein acetylation in bacteria.	Wang MM, You D, Ye BC.	Sci Rep	10.1038/s41598-017-13897-w	2017
Transcriptome	DDBJ with new system and face.	Sugawara H, Ogasawara O, Okubo K, Gojobori T, Tateno Y.	Nucleic Acids Res	10.1093/nar/gkm889	2008
Enzymology	6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.	Bevitt DJ, Cortes J, Haydock SF, Leadlay PF.	Eur J Biochem	10.1111/j.1432-1033.1992.tb16603.x	1992
	Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases.	Haydock SF, Dowson JA, Dhillon N, Roberts GA, Cortes J, Leadlay PF.	Mol Gen Genet	10.1007/bf00290659	1991
Enzymology	Cloning of a cluster of chitinase genes from Aeromonas sp. No. 10S-24.	Shiro M, Ueda M, Kawaguchi T, Arai M.	Biochim Biophys Acta	10.1016/0167-4781(95)00213-8	1996
	Site-specific recombination in Escherichia coli between the att sites of plasmid pSE211 from Saccharopolyspora erythraea.	Katz L, Brown DP, Donadio S.	Mol Gen Genet	10.1007/bf00260721	1991
	Rheologies and morphologies of three actinomycetes in submerged culture.	Warren SJ, Keshavarz-Moore E, Shamlou PA, Lilly MD, Thomas CR, Dixon K.	Biotechnol Bioeng	10.1002/bit.260450111	1995
Metabolism	Regulation of Sporangium Formation by BldD in the Rare Actinomycete Actinoplanes missouriensis.	Mouri Y, Konishi K, Fujita A, Tezuka T, Ohnishi Y.	J Bacteriol	10.1128/jb.00840-16	2017
Enzymology	Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage.	Cortes J, Wiesmann KE, Roberts GA, Brown MJ, Staunton J, Leadlay PF.	Science	10.1126/science.7770773	1995
	An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes.	Aigle B, Schneider D, Morilhat C, Vandewiele D, Dary A, Holl AC, Simonet JM, Decaris B.	Microbiology (Reading)	10.1099/13500872-142-10-2815	1996
	[Cloning of clusters of erythromycin biosynthesis genes of Streptomyces erythraeus (Saccharopolyspora erythraea)].	Ukhabotina LS, Danilenko VN, Navashin SM.	Antibiot Khimioter		1990
	Importance of the latex-clearing protein (Lcp) for poly(cis-1,4-isoprene) rubber cleavage in Streptomyces sp. K30.	Yikmis M, Steinbuchel A.	Microbiologyopen	10.1002/mbo3.3	2012
Metabolism	Protein Acetylation in Bacteria.	VanDrisse CM, Escalante-Semerena JC.	Annu Rev Microbiol	10.1146/annurev-micro-020518-115526	2019
	A novel insertion sequence (IS)-like element of the thermophilic bacterium PS3 promotes expression of the alanine carrier protein-encoding gene.	Murai N, Kamata H, Nagashima Y, Yagisawa H, Hirata H.	Gene	10.1016/0378-1119(95)00384-i	1995
Metabolism	Erythromycin biosynthesis. Highly efficient incorporation of polyketide chain elongation intermediates into 6-deoxyerythronolide B in an engineered Streptomyces host.	Cane DE, Luo G, Khosla C, Kao CM, Katz L.	J Antibiot (Tokyo)	10.7164/antibiotics.48.647	1995
Metabolism	Systematic analysis of the lysine acetylome in Fusarium graminearum.	Zhou S, Yang Q, Yin C, Liu L, Liang W.	BMC Genomics	10.1186/s12864-016-3361-3	2016
Metabolism	Polyketide synthesis in vitro on a modular polyketide synthase.	Wiesmann KE, Cortes J, Brown MJ, Cutter AL, Staunton J, Leadlay PF.	Chem Biol	10.1016/1074-5521(95)90122-1	1995
Metabolism	Characterization of P450 FcpC, the enzyme responsible for bioconversion of diosgenone to isonuatigenone in Streptomyces virginiae IBL-14.	Wang W, Wang FQ, Wei DZ.	Appl Environ Microbiol	10.1128/aem.02606-08	2009
Enzymology	Overexpression of penicillin V acylase from Streptomyces lavendulae and elucidation of its catalytic residues.	Torres-Bacete J, Hormigo D, Torres-Guzman R, Arroyo M, Castillon MP, Garcia L, Acebal C, de la Mata I.	Appl Environ Microbiol	10.1128/aem.02352-14	2015
	A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var. beijingensis.	Shen J, Kong L, Li Y, Zheng X, Wang Q, Yang W, Deng Z, You D.	Synth Syst Biotechnol	10.1016/j.synbio.2018.12.004	2019
	An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.	Cortes J, Haydock SF, Roberts GA, Bevitt DJ, Leadlay PF.	Nature	10.1038/348176a0	1990
Metabolism	A repeated decapeptide motif in the C-terminal domain of the ribosomal RNA methyltransferase from the erythromycin producer Saccharopolyspora erythraea.	Dhillon N, Leadlay PF.	FEBS Lett	10.1016/0014-5793(90)80186-m	1990
	GlnR Activation Induces Peroxide Resistance in Mycobacterial Biofilms.	Yang Y, Richards JP, Gundrum J, Ojha AK.	Front Microbiol	10.3389/fmicb.2018.01428	2018
	Formulation optimization of erythromycin solid lipid nanocarrier using response surface methodology.	Sahu AK, Kumar T, Jain V.	Biomed Res Int	10.1155/2014/689391	2014
Metabolism	Mining the metabiome: identifying novel natural products from microbial communities.	Milshteyn A, Schneider JS, Brady SF.	Chem Biol	10.1016/j.chembiol.2014.08.006	2014
	Identification of a gene required for the terminal step in erythromycin A biosynthesis in Saccharopolyspora erythraea (Streptomyces erythreus).	Weber JM, Schoner B, Losick R.	Gene	10.1016/0378-1119(89)90269-2	1989
	Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome.	Merson-Davies LA, Cundliffe E.	Mol Microbiol	10.1111/j.1365-2958.1994.tb00428.x	1994
	The use of a chromosome integration vector to map erythromycin resistance and production genes in Saccharopolyspora erythraea (Streptomyces erythraeus).	Weber JM, Losick R.	Gene	10.1016/0378-1119(88)90019-4	1988
Metabolism	A cytochrome P450-like gene possibly involved in oleandomycin biosynthesis by Streptomyces antibioticus.	Rodriguez AM, Olano C, Mendez C, Hutchinson CR, Salas JA.	FEMS Microbiol Lett	10.1111/j.1574-6968.1995.tb07459.x	1995
	Characterization of SE-3, a virulent bacteriophage of Saccharopolyspora erythraea.	Smorawinska M, Denis F, Dery CV, Magny P, Brzezinski R.	J Gen Microbiol	10.1099/00221287-134-7-1773	1988
Metabolism	Assembly of a novel biosynthetic pathway for gentamicin B production in Micromonospora echinospora.	Ni X, Sun Z, Gu Y, Cui H, Xia H.	Microb Cell Fact	10.1186/s12934-015-0402-6	2016
	The evolutionary advantage of an aromatic clamp in plant family 3 glycoside exo-hydrolases.	Luang S, Fernandez-Luengo X, Nin-Hill A, Streltsov VA, Schwerdt JG, Alonso-Gil S, Ketudat Cairns JR, Pradeau S, Fort S, Marechal JD, Masgrau L, Rovira C, Hrmova M.	Nat Commun	10.1038/s41467-022-33180-5	2022
	Morphology and mechanics of fungal mycelium.	Islam MR, Tudryn G, Bucinell R, Schadler L, Picu RC.	Sci Rep	10.1038/s41598-017-13295-2	2017
	Molecular characterization of a gene from Saccharopolyspora erythraea (Streptomyces erythraeus) which is involved in erythromycin biosynthesis.	Dhillon N, Hale RS, Cortes J, Leadlay PF.	Mol Microbiol	10.1111/j.1365-2958.1989.tb00123.x	1989
	N-Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics.	Schneider O, Zehl M, Ueoka R, Ruckert C, Buche T, Jiang Y, Li QY, Piel J, Zotchev SB.	mBio	10.1128/mbio.01789-22	2022
Metabolism	Multifunctional SEVA shuttle vectors for actinomycetes and Gram-negative bacteria.	Garcia-Gutierrez C, Aparicio T, Torres-Sanchez L, Martinez-Garcia E, de Lorenzo V, Villar CJ, Lombo F.	Microbiologyopen	10.1002/mbo3.1024	2020
	Encapsulation of erythromycin and bacitracin antibiotics into natural sporopollenin microcapsules: antibacterial, cytotoxicity, in vitro and in vivo release studies for enhanced bioavailability.	Dyab AKF, Mohamed MA, Meligi NM, Mohamed SK.	RSC Adv	10.1039/c8ra05499a	2018
Enzymology	Purification of thymidine-diphospho-D-glucose 4,6-dehydratase from an erythromycin-producing strain of Saccharopolyspora erythraea by high resolution liquid chromatography.	Vara JA, Hutchinson CR.	J Biol Chem	10.1016/s0021-9258(18)68136-0	1988
	Taxonomy and Broad-Spectrum Antifungal Activity of Streptomyces sp. SCA3-4 Isolated From Rhizosphere Soil of Opuntia stricta.	Qi D, Zou L, Zhou D, Chen Y, Gao Z, Feng R, Zhang M, Li K, Xie J, Wang W.	Front Microbiol	10.3389/fmicb.2019.01390	2019
Metabolism	The logic, experimental steps, and potential of heterologous natural product biosynthesis featuring the complex antibiotic erythromycin A produced through E. coli.	Jiang M, Zhang H, Pfeifer BA.	J Vis Exp	10.3791/4346	2013
	Architecture of the polyketide synthase module: surprises from electron cryo-microscopy.	Smith JL, Skiniotis G, Sherman DH.	Curr Opin Struct Biol	10.1016/j.sbi.2015.02.014	2015
Metabolism	MnoSR Is a Bona Fide Two-Component System Involved in Methylotrophic Metabolism in Mycobacterium smegmatis.	Dubey AA, Jain V.	Appl Environ Microbiol	10.1128/aem.00535-19	2019
Enzymology	Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence.	Swan DG, Rodriguez AM, Vilches C, Mendez C, Salas JA.	Mol Gen Genet	10.1007/bf00280426	1994
Metabolism	4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of gamma-glutamyltranspeptidase homolog for C-C bond cleavage.	Zhong G, Zhao Q, Zhang Q, Liu W.	Nat Commun	10.1038/ncomms16109	2017
Biotechnology	Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease-A Systematic Literature Review.	De La Hoz-Romo MC, Diaz L, Villamil L.	Antibiotics (Basel)	10.3390/antibiotics11070965	2022
Metabolism	Antibiotic producing potentials of three freshwater actinomycetes isolated from the Eastern Cape Province of South Africa.	Sibanda T, Mabinya LV, Mazomba N, Akinpelu DA, Bernard K, Olaniran AO, Okoh AI.	Int J Mol Sci	10.3390/ijms11072612	2010
	From Worms to Drug Candidate: The Story of Odilorhabdins, a New Class of Antimicrobial Agents.	Racine E, Gualtieri M.	Front Microbiol	10.3389/fmicb.2019.02893	2019
Metabolism	Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia.	Bi J, Gou Z, Zhou F, Chen Y, Gan J, Liu J, Wang H, Zhang X.	Emerg Microbes Infect	10.1038/s41426-018-0112-3	2018
Enzymology	Macrolide antibiotic biosynthesis: isolation and properties of two forms of 6-deoxyerythronolide B hydroxylase from Saccharopolyspora erythraea (Streptomyces erythreus).	Shafiee A, Hutchinson CR.	Biochemistry	10.1021/bi00393a037	1987
Metabolism	Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.	Koryakina I, Kasey C, McArthur JB, Lowell AN, Chemler JA, Li S, Hansen DA, Sherman DH, Williams GJ.	ACS Chem Biol	10.1021/acschembio.6b00732	2017
Pathogenicity	Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes.	Tanaka Y, Kasahara K, Hirose Y, Murakami K, Kugimiya R, Ochi K.	J Bacteriol	10.1128/jb.00147-13	2013
	Biosynthesis of the erythromycin macrolactone and a rational approach for producing hybrid macrolides.	Donadio S, Staver MJ, McAlpine JB, Swanson SJ, Katz L.	Gene	10.1016/0378-1119(92)90546-2	1992
Enzymology	Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase.	Aparicio JF, Caffrey P, Marsden AF, Staunton J, Leadlay PF.	J Biol Chem	10.1016/s0021-9258(17)37226-5	1994
	Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid.	Tuan JS, Weber JM, Staver MJ, Leung JO, Donadio S, Katz L.	Gene	10.1016/0378-1119(90)90435-t	1990
	Co-Culture of Plant Beneficial Microbes as Source of Bioactive Metabolites.	Vinale F, Nicoletti R, Borrelli F, Mangoni A, Parisi OA, Marra R, Lombardi N, Lacatena F, Grauso L, Finizio S, Lorito M, Woo SL.	Sci Rep	10.1038/s41598-017-14569-5	2017
Enzymology	Analysis of antigens of Mycobacterium leprae by interaction to sera IgG, IgM, and IgA response to improve diagnosis of leprosy.	Kumar A, Parkash O, Girdhar BK.	Biomed Res Int	10.1155/2014/283278	2014
	Morphological and physiological characterization of filamentous Lentzea aerocolonigenes: Comparison of biopellets by microscopy and flow cytometry.	Schrinner K, Veiter L, Schmideder S, Doppler P, Schrader M, Munch N, Althof K, Kwade A, Briesen H, Herwig C, Krull R.	PLoS One	10.1371/journal.pone.0234125	2020
	Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.	Savino C, Montemiglio LC, Sciara G, Miele AE, Kendrew SG, Jemth P, Gianni S, Vallone B.	J Biol Chem	10.1074/jbc.m109.003590	2009
Enzymology	Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase.	Roberts GA, Staunton J, Leadlay PF.	Eur J Biochem	10.1111/j.1432-1033.1993.tb17925.x	1993
	The Skin Bacterium Propionibacterium acnes Employs Two Variants of Hyaluronate Lyase with Distinct Properties.	Nazipi S, Stodkilde-Jorgensen K, Scavenius C, Bruggemann H.	Microorganisms	10.3390/microorganisms5030057	2017
	Modular organization of genes required for complex polyketide biosynthesis.	Donadio S, Staver MJ, McAlpine JB, Swanson SJ, Katz L.	Science	10.1126/science.2024119	1991
Metabolism	Sonication-dependent electroporation of the erythromycin-producing bacterium Saccharopolyspora erythraea.	Fitzgerald NB, English RS, Lampel JS, Vanden Boom TJ.	Appl Environ Microbiol	10.1128/aem.64.4.1580-1583.1998	1998
	Regulation of Bottromycin Biosynthesis Involves an Internal Transcriptional Start Site and a Cluster-Situated Modulator.	Vior NM, Cea-Torrescassana E, Eyles TH, Chandra G, Truman AW.	Front Microbiol	10.3389/fmicb.2020.00495	2020
Metabolism	Short-chain ketone production by engineered polyketide synthases in Streptomyces albus.	Yuzawa S, Mirsiaghi M, Jocic R, Fujii T, Masson F, Benites VT, Baidoo EEK, Sundstrom E, Tanjore D, Pray TR, George A, Davis RW, Gladden JM, Simmons BA, Katz L, Keasling JD.	Nat Commun	10.1038/s41467-018-07040-0	2018
	Soil Bacteria Isolated From Tunisian Arid Areas Show Promising Antimicrobial Activities Against Gram-Negatives.	Nasfi Z, Busch H, Kehraus S, Linares-Otoya L, Konig GM, Schaberle TF, Bachoual R.	Front Microbiol	10.3389/fmicb.2018.02742	2018
Enzymology	Complex Evolution of Light-Dependent Protochlorophyllide Oxidoreductases in Aerobic Anoxygenic Phototrophs: Origin, Phylogeny, and Function.	Chernomor O, Peters L, Schneidewind J, Loeschcke A, Knieps-Grunhagen E, Schmitz F, von Lieres E, Kutta RJ, Svensson V, Jaeger KE, Drepper T, von Haeseler A, Krauss U.	Mol Biol Evol	10.1093/molbev/msaa234	2021
Metabolism	Unlocking Streptomyces spp. for use as sustainable industrial production platforms by morphological engineering.	van Wezel GP, Krabben P, Traag BA, Keijser BJ, Kerste R, Vijgenboom E, Heijnen JJ, Kraal B.	Appl Environ Microbiol	10.1128/aem.00808-06	2006
	Disclosing the Potential of the SARP-Type Regulator PapR2 for the Activation of Antibiotic Gene Clusters in Streptomycetes.	Krause J, Handayani I, Blin K, Kulik A, Mast Y.	Front Microbiol	10.3389/fmicb.2020.00225	2020
Metabolism	Promoter constructions for efficient secretion expression in Streptomyces lividans.	Schmitt-John T, Engels JW.	Appl Microbiol Biotechnol	10.1007/bf00170190	1992
Metabolism	Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes.	Makitrynskyy R, Tsypik O, Nuzzo D, Paululat T, Zechel DL, Bechthold A.	Nucleic Acids Res	10.1093/nar/gkz1220	2020
Enzymology	The Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific.	Lanois-Nouri A, Pantel L, Fu J, Houard J, Ogier JC, Polikanov YS, Racine E, Wang H, Gaudriault S, Givaudan A, Gualtieri M.	mBio	10.1128/mbio.02826-21	2022
Metabolism	Carbon Allocation in Rhodococcus jostii RHA1 in Response to Disruption and Overexpression of nlpR Regulatory Gene, Based on 13C-labeling Analysis.	Hernandez MA, Gleixner G, Sachse D, Alvarez HM.	Front Microbiol	10.3389/fmicb.2017.01992	2017
Metabolism	Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.	Gubbens J, Wu C, Zhu H, Filippov DV, Florea BI, Rigali S, Overkleeft HS, van Wezel GP.	ACS Chem Biol	10.1021/acschembio.7b00597	2017
Metabolism	The SsgA-like proteins in actinomycetes: small proteins up to a big task.	Traag BA, van Wezel GP.	Antonie Van Leeuwenhoek	10.1007/s10482-008-9225-3	2008
	NMR assignments, secondary structure, and global fold of calerythrin, an EF-hand calcium-binding protein from Saccharopolyspora erythraea.	Aitio H, Annila A, Heikkinen S, Thulin E, Drakenberg T, Kilpelainen I.	Protein Sci	10.1110/ps.8.12.2580	1999
Enzymology	Purification and characterization of TDP-D-glucose 4,6-dehydratase from anthracycline-producing streptomycetes.	Thompson MW, Strohl WR, Floss HG.	J Gen Microbiol	10.1099/00221287-138-4-779	1992
Metabolism	Differential roles of the hemerythrin-like proteins of Mycobacterium smegmatis in hydrogen peroxide and erythromycin susceptibility.	Li X, Li J, Hu X, Huang L, Xiao J, Chan J, Mi K.	Sci Rep	10.1038/srep16130	2015
Genetics	A Highly Efficient CRISPR-Cas9-Mediated Large Genomic Deletion in Bacillus subtilis.	So Y, Park SY, Park EH, Park SH, Kim EJ, Pan JG, Choi SK.	Front Microbiol	10.3389/fmicb.2017.01167	2017
Biotechnology	Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus.	Unsaldi E, Kurt-Kizildogan A, Voigt B, Becher D, Ozcengiz G.	Synth Syst Biotechnol	10.1016/j.synbio.2016.10.003	2017
	De Novo Biosynthesis of Apigenin, Luteolin, and Eriodictyol in the Actinomycete Streptomyces albus and Production Improvement by Feeding and Spore Conditioning.	Marin L, Gutierrez-Del-Rio I, Yague P, Manteca A, Villar CJ, Lombo F.	Front Microbiol	10.3389/fmicb.2017.00921	2017
Metabolism	A novel enzyme with antioxidant capacity produced by the ubiquitous skin colonizer Propionibacterium acnes.	Allhorn M, Arve S, Bruggemann H, Lood R.	Sci Rep	10.1038/srep36412	2016
Pathogenicity	Phenotypic suppression by aminoglycoside antibiotics of mutations blocking erythromycin biosynthesis in Saccharopolyspora erythraea.	Lewandowska-Skarbek M, Hutchinson CR.	J Bacteriol	10.1128/jb.172.11.6605-6606.1990	1990
	Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids.	Wu C, Zhu H, van Wezel GP, Choi YH.	Metabolomics	10.1007/s11306-016-1025-6	2016
Enzymology	Evolutionary Relationships Between Low Potential Ferredoxin and Flavodoxin Electron Carriers.	Campbell IJ, Bennett GN, Silberg JJ.	Front Energy Res	10.3389/fenrg.2019.00079	2019
Metabolism	Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.	Lechner A, Eustaquio AS, Gulder TA, Hafner M, Moore BS.	Chem Biol	10.1016/j.chembiol.2011.10.014	2011
	Rifampicin-Resistance Mutations in the rpoB Gene in Bacillus velezensis CC09 have Pleiotropic Effects.	Cai XC, Xi H, Liang L, Liu JD, Liu CH, Xue YR, Yu XY.	Front Microbiol	10.3389/fmicb.2017.00178	2017
Metabolism	A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.	Nardiz N, Santamarta I, Lorenzana LM, Martin JF, Liras P.	Microb Biotechnol	10.1111/j.1751-7915.2010.00222.x	2011
Proteome	Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding.	Alexander LM, Goldman DH, Wee LM, Bustamante C.	Nat Commun	10.1038/s41467-019-10647-6	2019
Genetics	Epilithic Biofilms in Lake Baikal: Screening and Diversity of PKS and NRPS Genes in the Genomes of Heterotrophic Bacteria.	Sukhanova E, Zimens E, Kaluzhnaya O, Parfenova V, Belykh O.	Pol J Microbiol	10.21307/pjm-2018-060	2018
	A Novel Alkaliphilic Streptomyces Inhibits ESKAPE Pathogens.	Terra L, Dyson PJ, Hitchings MD, Thomas L, Abdelhameed A, Banat IM, Gazze SA, Vujaklija D, Facey PD, Francis LW, Quinn GA.	Front Microbiol	10.3389/fmicb.2018.02458	2018
Metabolism	Signaling specificity in the c-di-GMP-dependent network regulating antibiotic synthesis in Lysobacter.	Xu G, Han S, Huo C, Chin KH, Chou SH, Gomelsky M, Qian G, Liu F.	Nucleic Acids Res	10.1093/nar/gky803	2018
	Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold.	Shao Z, Rao G, Li C, Abil Z, Luo Y, Zhao H.	ACS Synth Biol	10.1021/sb400058n	2013
Pathogenicity	Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex.	Buriankova K, Doucet-Populaire F, Dorson O, Gondran A, Ghnassia JC, Weiser J, Pernodet JL.	Antimicrob Agents Chemother	10.1128/aac.48.1.143-150.2004	2004
Metabolism	Development of Transcription Factor-Based Designer Macrolide Biosensors for Metabolic Engineering and Synthetic Biology.	Kasey CM, Zerrad M, Li Y, Cropp TA, Williams GJ.	ACS Synth Biol	10.1021/acssynbio.7b00287	2018
Metabolism	Characterization of apo and partially saturated states of calerythrin, an EF-hand protein from S. erythraea: a molten globule when deprived of Ca(2+).	Aitio H, Laakso T, Pihlajamaa T, Torkkeli M, Kilpelainen I, Drakenberg T, Serimaa R, Annila A.	Protein Sci	10.1110/ps.31201	2001
Metabolism	Structural analysis of cytochrome P450 105N1 involved in the biosynthesis of the zincophore, coelibactin.	Zhao B, Moody SC, Hider RC, Lei L, Kelly SL, Waterman MR, Lamb DC.	Int J Mol Sci	10.3390/ijms13078500	2012
Metabolism	Discovery of Unusual Biaryl Polyketides by Activation of a Silent Streptomyces venezuelae Biosynthetic Gene Cluster.	Thanapipatsiri A, Gomez-Escribano JP, Song L, Bibb MJ, Al-Bassam M, Chandra G, Thamchaipenet A, Challis GL, Bibb MJ.	Chembiochem	10.1002/cbic.201600396	2016
Metabolism	Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway in Micromonospora sp. Strain TP-A0468.	Zhou Q, Luo GC, Zhang H, Tang GL.	Appl Environ Microbiol	10.1128/aem.02597-18	2019
Metabolism	Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering.	Gao W, Wu Z, Sun J, Ni X, Xia H.	PLoS One	10.1371/journal.pone.0181971	2017
Enzymology	New approaches to achieve high level enzyme production in Streptomyces lividans.	Sevillano L, Vijgenboom E, van Wezel GP, Diaz M, Santamaria RI.	Microb Cell Fact	10.1186/s12934-016-0425-7	2016
	Actinomycetes, an Inexhaustible Source of Naturally Occurring Antibiotics.	Takahashi Y, Nakashima T.	Antibiotics (Basel)	10.3390/antibiotics7020045	2018
	In silico biosynthesis of virenose, a methylated deoxy-sugar unique to Coxiella burnetii lipopolysaccharide.	Flores-Ramirez G, Janecek S, Miernyk JA, Skultety L.	Proteome Sci	10.1186/1477-5956-10-67	2012
	Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway.	Stulberg ER, Lozano GL, Morin JB, Park H, Baraban EG, Mlot C, Heffelfinger C, Phillips GM, Rush JS, Phillips AJ, Broderick NA, Thomas MG, Stabb EV, Handelsman J.	Front Microbiol	10.3389/fmicb.2016.00573	2016
	Evolution of the F0F1 ATP synthase complex in light of the patchy distribution of different bioenergetic pathways across prokaryotes.	Koumandou VL, Kossida S.	PLoS Comput Biol	10.1371/journal.pcbi.1003821	2014
Metabolism	The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.	Galm U, Wendt-Pienkowski E, Wang L, George NP, Oh TJ, Yi F, Tao M, Coughlin JM, Shen B.	Mol Biosyst	10.1039/b814075h	2009
Enzymology	Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase.	Edwards AL, Matsui T, Weiss TM, Khosla C.	J Mol Biol	10.1016/j.jmb.2014.03.015	2014
Metabolism	Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket.	Harvey CJ, Puglisi JD, Pande VS, Cane DE, Khosla C.	J Am Chem Soc	10.1021/ja304682q	2012
	Repurposing type III polyketide synthase as a malonyl-CoA biosensor for metabolic engineering in bacteria.	Yang D, Kim WJ, Yoo SM, Choi JH, Ha SH, Lee MH, Lee SY.	Proc Natl Acad Sci U S A	10.1073/pnas.1808567115	2018
Enzymology	Diversity analysis of streptomycetes and associated phosphotranspherase genes in soil.	Laskaris P, Sekine T, Wellington EM.	PLoS One	10.1371/journal.pone.0035756	2012
Metabolism	Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli.	Zhang H, Boghigian BA, Pfeifer BA.	Biotechnol Bioeng	10.1002/bit.22560	2010
	Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity.	Cupp-Vickery J, Anderson R, Hatziris Z.	Proc Natl Acad Sci U S A	10.1073/pnas.97.7.3050	2000
	Molecular evolution of hydrogen peroxide degrading enzymes.	Zamocky M, Gasselhuber B, Furtmuller PG, Obinger C.	Arch Biochem Biophys	10.1016/j.abb.2012.01.017	2012
Metabolism	Biosynthesis of 2-methylisoborneol in cyanobacteria.	Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT.	Environ Sci Technol	10.1021/es102992p	2011
Metabolism	The adnAB locus, encoding a putative helicase-nuclease activity, is essential in Streptomyces.	Zhang L, Nguyen HC, Chipot L, Piotrowski E, Bertrand C, Thibessard A, Leblond P.	J Bacteriol	10.1128/jb.01513-14	2014
Metabolism	The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism.	Duan L, Jogl G, Cane DE.	J Am Chem Soc	10.1021/jacs.6b08610	2016
Metabolism	Purification and separation of holo- and apo-forms of Saccharopolyspora erythraea acyl-carrier protein released from recombinant Escherichia coli by freezing and thawing.	Morris SA, Revill WP, Staunton J, Leadlay PF.	Biochem J	10.1042/bj2940521	1993
	The Balance Metabolism Safety Net: Integration of Stress Signals by Interacting Transcriptional Factors in Streptomyces and Related Actinobacteria.	Martin JF, Liras P.	Front Microbiol	10.3389/fmicb.2019.03120	2019
Pathogenicity	Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics.	Jednacak T, Mikulandra I, Novak P.	Int J Mol Sci	10.3390/ijms21207799	2020
Metabolism	Protein Acetylation and Butyrylation Regulate the Phenotype and Metabolic Shifts of the Endospore-forming Clostridium acetobutylicum.	Xu JY, Xu Z, Liu X, Tan M, Ye BC.	Mol Cell Proteomics	10.1074/mcp.ra117.000372	2018
Metabolism	Exploration and mining of the bacterial terpenome.	Cane DE, Ikeda H.	Acc Chem Res	10.1021/ar200198d	2012
	An integrative expression vector for Actinosynnema pretiosum.	Goh S, Camattari A, Ng D, Song R, Madden K, Westpheling J, Wong VV.	BMC Biotechnol	10.1186/1472-6750-7-72	2007
	Sequence and structural evolution of the KsgA/Dim1 methyltransferase family.	O'Farrell HC, Xu Z, Culver GM, Rife JP.	BMC Res Notes	10.1186/1756-0500-1-108	2008
Metabolism	Diversity of P450 enzymes in the biosynthesis of natural products.	Podust LM, Sherman DH.	Nat Prod Rep	10.1039/c2np20020a	2012
	Characterization of a Novel Nicotine Degradation Gene Cluster ndp in Sphingomonas melonis TY and Its Evolutionary Analysis.	Wang H, Zhi XY, Qiu J, Shi L, Lu Z.	Front Microbiol	10.3389/fmicb.2017.00337	2017
	Streptopyridines, volatile pyridine alkaloids produced by Streptomyces sp. FORM5.	Groenhagen U, Maczka M, Dickschat JS, Schulz S.	Beilstein J Org Chem	10.3762/bjoc.10.146	2014
Metabolism	FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis.	Goranovic D, Blazic M, Magdevska V, Horvat J, Kuscer E, Polak T, Santos-Aberturas J, Martinez-Castro M, Barreiro C, Mrak P, Kopitar G, Kosec G, Fujs S, Martin JF, Petkovic H.	BMC Microbiol	10.1186/1471-2180-12-238	2012
Enzymology	Putative monofunctional type I polyketide synthase units: a dinoflagellate-specific feature?	Eichholz K, Beszteri B, John U.	PLoS One	10.1371/journal.pone.0048624	2012
	Dam and Dcm methylations prevent gene transfer into Clostridium pasteurianum NRRL B-598: development of methods for electrotransformation, conjugation, and sonoporation.	Kolek J, Sedlar K, Provaznik I, Patakova P.	Biotechnol Biofuels	10.1186/s13068-016-0436-y	2016
Genetics	Genome Analysis of Two Pseudonocardia Phylotypes Associated with Acromyrmex Leafcutter Ants Reveals Their Biosynthetic Potential.	Holmes NA, Innocent TM, Heine D, Bassam MA, Worsley SF, Trottmann F, Patrick EH, Yu DW, Murrell JC, Schiott M, Wilkinson B, Boomsma JJ, Hutchings MI.	Front Microbiol	10.3389/fmicb.2016.02073	2016
	Transcriptional organization of the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea.	Reeves AR, English RS, Lampel JS, Post DA, Vanden Boom TJ.	J Bacteriol	10.1128/jb.181.22.7098-7106.1999	1999
Enzymology	A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate.	Park H, Kevany BM, Dyer DH, Thomas MG, Forest KT.	PLoS One	10.1371/journal.pone.0110965	2014
	Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.	Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L.	Antimicrob Agents Chemother	10.1128/aac.44.5.1214-1222.2000	2000
Metabolism	Multimodular type I polyketide synthases in algae evolve by module duplications and displacement of AT domains in trans.	Shelest E, Heimerl N, Fichtner M, Sasso S.	BMC Genomics	10.1186/s12864-015-2222-9	2015
Pathogenicity	Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases.	Cheong DHJ, Tan DWS, Wong FWS, Tran T.	Pharmacol Res	10.1016/j.phrs.2020.104901	2020
Metabolism	Overproduction of Ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17.	Spohn M, Kirchner N, Kulik A, Jochim A, Wolf F, Muenzer P, Borst O, Gross H, Wohlleben W, Stegmann E.	Antimicrob Agents Chemother	10.1128/aac.03512-14	2014
	Strategies for Fermentation Medium Optimization: An In-Depth Review.	Singh V, Haque S, Niwas R, Srivastava A, Pasupuleti M, Tripathi CK.	Front Microbiol	10.3389/fmicb.2016.02087	2016
Metabolism	Allosteric regulation of a protein acetyltransferase in Micromonospora aurantiaca by the amino acids cysteine and arginine.	Xu JY, You D, Leng PQ, Ye BC.	J Biol Chem	10.1074/jbc.m114.579078	2014
Metabolism	A Pseudomonas aeruginosa EF-hand protein, EfhP (PA4107), modulates stress responses and virulence at high calcium concentration.	Sarkisova SA, Lotlikar SR, Guragain M, Kubat R, Cloud J, Franklin MJ, Patrauchan MA.	PLoS One	10.1371/journal.pone.0098985	2014
Enzymology	Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosa.	Madduri K, Waldron C, Merlo DJ.	J Bacteriol	10.1128/jb.183.19.5632-5638.2001	2001
Enzymology	Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600.	Huang SX, Zhao LX, Tang SK, Jiang CL, Duan Y, Shen B.	Org Lett	10.1021/ol900143j	2009
Metabolism	Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii.	Castro JF, Razmilic V, Gomez-Escribano JP, Andrews B, Asenjo JA, Bibb MJ.	Appl Environ Microbiol	10.1128/aem.01039-15	2015
	Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering.	Stassi DL, Kakavas SJ, Reynolds KA, Gunawardana G, Swanson S, Zeidner D, Jackson M, Liu H, Buko A, Katz L.	Proc Natl Acad Sci U S A	10.1073/pnas.95.13.7305	1998
Metabolism	Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.	Olano C, Garcia I, Gonzalez A, Rodriguez M, Rozas D, Rubio J, Sanchez-Hidalgo M, Brana AF, Mendez C, Salas JA.	Microb Biotechnol	10.1111/1751-7915.12116	2014
	An engineered strong promoter for streptomycetes.	Wang W, Li X, Wang J, Xiang S, Feng X, Yang K.	Appl Environ Microbiol	10.1128/aem.00985-13	2013
Metabolism	A MarR Family Transcriptional Regulator, DptR3, Activates Daptomycin Biosynthesis and Morphological Differentiation in Streptomyces roseosporus.	Zhang Q, Chen Q, Zhuang S, Chen Z, Wen Y, Li J.	Appl Environ Microbiol	10.1128/aem.00057-15	2015
Metabolism	Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related organisms.	Ziemski M, Jomaa A, Jomaa A, Mayer D, Rutz S, Giese C, Veprintsev D, Weber-Ban E.	Elife	10.7554/elife.34055	2018
	A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum.	Chooi YH, Muria-Gonzalez MJ, Solomon PS.	Mycology	10.1080/21501203.2014.928386	2014
Proteome	Dynamic Characterization of Protein and Posttranslational Modification Levels in Mycobacterial Cholesterol Catabolism.	Xu JY, Zhao L, Xu Y, Li B, Zhai L, Tan M, Ye BC.	mSystems	10.1128/msystems.00424-19	2020
	Reactivity of platelia Aspergillus galactomannan antigen with piperacillin-tazobactam: clinical implications based on achievable concentrations in serum.	Singh N, Obman A, Husain S, Aspinall S, Mietzner S, Stout JE.	Antimicrob Agents Chemother	10.1128/aac.48.6.1989-1992.2004	2004
Pathogenicity	Small-molecule elicitation of microbial secondary metabolites.	Pettit RK.	Microb Biotechnol	10.1111/j.1751-7915.2010.00196.x	2011
Metabolism	Direct Involvement of the Master Nitrogen Metabolism Regulator GlnR in Antibiotic Biosynthesis in Streptomyces.	He JM, Zhu H, Zheng GS, Liu PP, Wang J, Zhao GP, Zhu GQ, Jiang WH, Lu YH.	J Biol Chem	10.1074/jbc.m116.762476	2016
Metabolism	Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess.	Boghigian BA, Myint M, Wu J, Pfeifer BA.	J Ind Microbiol Biotechnol	10.1007/s10295-011-0969-9	2011
Metabolism	Regulation, Function, and Detection of Protein Acetylation in Bacteria.	Carabetta VJ, Cristea IM.	J Bacteriol	10.1128/jb.00107-17	2017
	Disruption of a rhodaneselike gene results in cysteine auxotrophy in Saccharopolyspora erythraea.	Donadio S, Shafiee A, Hutchinson CR.	J Bacteriol	10.1128/jb.172.1.350-360.1990	1990
Metabolism	A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis.	Guo J, Zhang X, Luo S, He F, Chen Z, Wen Y, Li J.	PLoS One	10.1371/journal.pone.0071330	2013
Transcriptome	Systems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains.	Li YY, Chang X, Yu WB, Li H, Ye ZQ, Yu H, Liu BH, Zhang Y, Zhang SL, Ye BC, Li YX.	BMC Genomics	10.1186/1471-2164-14-523	2013
Metabolism	An erythromycin analog produced by reprogramming of polyketide synthesis.	Donadio S, McAlpine JB, Sheldon PJ, Jackson M, Katz L.	Proc Natl Acad Sci U S A	10.1073/pnas.90.15.7119	1993
Metabolism	Establishment of the Inducible Tet-On System for the Activation of the Silent Trichosetin Gene Cluster in Fusarium fujikuroi.	Janevska S, Arndt B, Baumann L, Apken LH, Mauriz Marques LM, Humpf HU, Tudzynski B.	Toxins (Basel)	10.3390/toxins9040126	2017
Metabolism	Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.	Trefzer A, Pelzer S, Schimana J, Stockert S, Bihlmaier C, Fiedler HP, Welzel K, Vente A, Bechthold A.	Antimicrob Agents Chemother	10.1128/aac.46.5.1174-1182.2002	2002
	Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.	Choulet F, Gallois A, Aigle B, Mangenot S, Gerbaud C, Truong C, Francou FX, Borges F, Fourrier C, Guerineau M, Decaris B, Barbe V, Pernodet JL, Leblond P.	J Bacteriol	10.1128/jb.00734-06	2006
Metabolism	A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria.	Larrouy-Maumus G, Skovierova H, Dhouib R, Angala SK, Zuberogoitia S, Pham H, Villela AD, Mikusova K, Noguera A, Gilleron M, Valentinova L, Kordulakova J, Brennan PJ, Puzo G, Nigou J, Jackson M.	J Biol Chem	10.1074/jbc.m112.400986	2012
Metabolism	Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae.	Jung WS, Jeong SJ, Park SR, Choi CY, Park BC, Park JW, Yoon YJ.	Appl Environ Microbiol	10.1128/aem.02296-07	2008
	Symbiosis-specific expression of Rhizobium etli casA encoding a secreted calmodulin-related protein.	Xi C, Schoeters E, Vanderleyden J, Michiels J.	Proc Natl Acad Sci U S A	10.1073/pnas.210181097	2000
Metabolism	Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008.	Wu H, Qu S, Lu C, Zheng H, Zhou X, Bai L, Deng Z.	BMC Genomics	10.1186/1471-2164-13-337	2012
	A Review of the Microbial Production of Bioactive Natural Products and Biologics.	Pham JV, Yilma MA, Feliz A, Majid MT, Maffetone N, Walker JR, Kim E, Cho HJ, Reynolds JM, Song MC, Park SR, Yoon YJ.	Front Microbiol	10.3389/fmicb.2019.01404	2019
Metabolism	Control of directionality in integrase-mediated recombination: examination of recombination directionality factors (RDFs) including Xis and Cox proteins.	Lewis JA, Hatfull GF.	Nucleic Acids Res	10.1093/nar/29.11.2205	2001
	Characterization of Streptomyces spp. isolated from the sea surface microlayer in the Trondheim Fjord, Norway.	Hakvag S, Fjaervik E, Josefsen KD, Ian E, Ellingsen TE, Zotchev SB.	Mar Drugs	10.3390/md6040620	2008
Metabolism	Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.	Chen D, Zhang Q, Zhang Q, Cen P, Xu Z, Liu W.	Appl Environ Microbiol	10.1128/aem.00450-12	2012
	Manipulating natural product biosynthetic pathways via DNA assembler.	Shao Z, Zhao H.	Curr Protoc Chem Biol	10.1002/9780470559277.ch130191	2014
	Experimental mapping of soluble protein domains using a hierarchical approach.	Pedelacq JD, Nguyen HB, Cabantous S, Mark BL, Listwan P, Bell C, Friedland N, Lockard M, Faille A, Mourey L, Terwilliger TC, Waldo GS.	Nucleic Acids Res	10.1093/nar/gkr548	2011
Metabolism	Novel extracellular PHB depolymerase from Streptomyces ascomycinicus: PHB copolymers degradation in acidic conditions.	Garcia-Hidalgo J, Hormigo D, Arroyo M, de la Mata I.	PLoS One	10.1371/journal.pone.0071699	2013
Metabolism	Novel marine actinobacteria from emerald Andaman & Nicobar Islands: a prospective source for industrial and pharmaceutical byproducts.	Meena B, Rajan LA, Vinithkumar NV, Kirubagaran R.	BMC Microbiol	10.1186/1471-2180-13-145	2013
	Inhibition of erythromycin synthesis by disruption of malonyl-coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea.	Hsieh YJ, Kolattukudy PE.	J Bacteriol	10.1128/jb.176.3.714-724.1994	1994
Metabolism	Comparative analysis of glycoside hydrolases activities from phylogenetically diverse marine bacteria of the genus Arenibacter.	Bakunina I, Nedashkovskaya O, Balabanova L, Zvyagintseva T, Rasskasov V, Mikhailov V.	Mar Drugs	10.3390/md11061977	2013
	Integrative gene cloning and expression system for Streptomyces sp. US 24 and Streptomyces sp. TN 58 bioactive molecule producing strains.	Sioud S, Aigle B, Karray-Rebai I, Smaoui S, Bejar S, Mellouli L.	J Biomed Biotechnol	10.1155/2009/464986	2009
Metabolism	Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions.	Boghigian BA, Zhang H, Pfeifer BA.	Biotechnol Bioeng	10.1002/bit.23069	2011
Metabolism	The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases.	Newton GL, Leung SS, Wakabayashi JI, Rawat M, Fahey RC.	Biochemistry	10.1021/bi201460j	2011
	Actinomycete integrative and conjugative elements.	te Poele EM, Bolhuis H, Dijkhuizen L.	Antonie Van Leeuwenhoek	10.1007/s10482-008-9255-x	2008
	New erm Gene in Staphylococcus aureus clinical isolates.	Matsuoka M, Inoue M, Nakajima Y, Endo Y.	Antimicrob Agents Chemother	10.1128/aac.46.1.211-215.2002	2002
Metabolism	Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.	Mendes MV, Anton N, Martin JF, Aparicio JF.	Biochem J	10.1042/bj20040490	2005
	Characterization of the genetic elements required for site-specific integration of plasmid pSE211 in Saccharopolyspora erythraea.	Brown DP, Idler KB, Katz L.	J Bacteriol	10.1128/jb.172.4.1877-1888.1990	1990
	Structure-based dissociation of a type I polyketide synthase module.	Chen AY, Cane DE, Khosla C.	Chem Biol	10.1016/j.chembiol.2007.05.015	2007
Metabolism	Engineering anthracycline biosynthesis toward angucyclines.	Metsa-Ketela M, Palmu K, Kunnari T, Ylihonko K, Mantsala P.	Antimicrob Agents Chemother	10.1128/aac.47.4.1291-1296.2003	2003
Metabolism	Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.	Fernandez E, Weissbach U, Sanchez Reillo C, Brana AF, Mendez C, Rohr J, Salas JA.	J Bacteriol	10.1128/jb.180.18.4929-4937.1998	1998
Metabolism	Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.	Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B.	Biochemistry	10.1021/bi501396v	2014
Metabolism	Mycelium differentiation and antibiotic production in submerged cultures of Streptomyces coelicolor.	Manteca A, Alvarez R, Salazar N, Yague P, Sanchez J.	Appl Environ Microbiol	10.1128/aem.02715-07	2008
	Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli.	Lee HY, Khosla C.	PLoS Biol	10.1371/journal.pbio.0050045	2007
Metabolism	Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferase.	Vester B, Douthwaite S.	J Bacteriol	10.1128/jb.176.22.6999-7004.1994	1994
Enzymology	Evolution of polyketide synthases in bacteria.	Ridley CP, Lee HY, Khosla C.	Proc Natl Acad Sci U S A	10.1073/pnas.0710107105	2008
	Miniature bioreactors: current practices and future opportunities.	Betts JI, Baganz F.	Microb Cell Fact	10.1186/1475-2859-5-21	2006
Metabolism	Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.	Warrilow AG, Jackson CJ, Parker JE, Marczylo TH, Kelly DE, Lamb DC, Kelly SL.	Antimicrob Agents Chemother	10.1128/aac.01237-08	2009
Metabolism	Radical SAM enzymes in the biosynthesis of sugar-containing natural products.	Ruszczycky MW, Ogasawara Y, Liu HW.	Biochim Biophys Acta	10.1016/j.bbapap.2011.11.006	2012
Metabolism	Combinatorial biosynthesis of antitumor indolocarbazole compounds.	Sanchez C, Zhu L, Brana AF, Salas AP, Rohr J, Mendez C, Salas JA.	Proc Natl Acad Sci U S A	10.1073/pnas.0407809102	2005
Metabolism	Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes.	Seyedsayamdost MR, Traxler MF, Clardy J, Kolter R.	Methods Enzymol	10.1016/b978-0-12-404634-4.00005-x	2012
Genetics	Comparative genomics and functional analysis of rhamnose catabolic pathways and regulons in bacteria.	Rodionova IA, Li X, Thiel V, Stolyar S, Stanton K, Fredrickson JK, Bryant DA, Osterman AL, Best AA, Rodionov DA.	Front Microbiol	10.3389/fmicb.2013.00407	2013
	Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages.	Del Sol A, Arauzo-Bravo MJ, Amoros D, Nussinov R.	Genome Biol	10.1186/gb-2007-8-5-r92	2007
	An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.	Baughn AD, Garforth SJ, Vilcheze C, Jacobs WR.	PLoS Pathog	10.1371/journal.ppat.1000662	2009
Metabolism	Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis.	Jenke-Kodama H, Borner T, Dittmann E.	PLoS Comput Biol	10.1371/journal.pcbi.0020132	2006
Metabolism	Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.	Liu M, Douthwaite S.	Antimicrob Agents Chemother	10.1128/aac.46.6.1629-1633.2002	2002
Metabolism	Engineered biosynthesis of natural products in heterologous hosts.	Luo Y, Li BZ, Liu D, Zhang L, Chen Y, Jia B, Zeng BX, Zhao H, Yuan YJ.	Chem Soc Rev	10.1039/c5cs00025d	2015
Metabolism	Structure of an MmyB-like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes.	Xu Q, van Wezel GP, Chiu HJ, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA.	PLoS One	10.1371/journal.pone.0041359	2012
Metabolism	One step assembly of multiple DNA fragments with a designed order and orientation in Bacillus subtilis plasmid.	Tsuge K, Matsui K, Itaya M.	Nucleic Acids Res	10.1093/nar/gng133	2003
Pathogenicity	In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides.	Abbanat D, Webb G, Foleno B, Li Y, Macielag M, Montenegro D, Wira E, Bush K.	Antimicrob Agents Chemother	10.1128/aac.49.1.309-315.2005	2005
Metabolism	Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius.	Stutzman-Engwall KJ, Otten SL, Hutchinson CR.	J Bacteriol	10.1128/jb.174.1.144-154.1992	1992
	Synthetic ecosystems based on airborne inter- and intrakingdom communication.	Weber W, Daoud-El Baba M, Fussenegger M.	Proc Natl Acad Sci U S A	10.1073/pnas.0701382104	2007
Metabolism	Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.	Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W.	BMC Genomics	10.1186/1471-2164-15-363	2014
	Erythromycin Formulations-A Journey to Advanced Drug Delivery.	Platon VM, Dragoi B, Marin L.	Pharmaceutics	10.3390/pharmaceutics14102180	2022
Metabolism	Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027.	Wang L, Hu Y, Zhang Y, Wang S, Cui Z, Bao Y, Jiang W, Hong B.	BMC Microbiol	10.1186/1471-2180-9-14	2009
	ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures.	Starcevic A, Zucko J, Simunkovic J, Long PF, Cullum J, Hranueli D.	Nucleic Acids Res	10.1093/nar/gkn685	2008
Enzymology	Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1.	Murli S, MacMillan KS, Hu Z, Ashley GW, Dong SD, Kealey JT, Reeves CD, Kennedy J.	Appl Environ Microbiol	10.1128/aem.71.8.4503-4509.2005	2005
Metabolism	The genome of Rhodobacter sphaeroides strain 2.4.1 encodes functional cobinamide salvaging systems of archaeal and bacterial origins.	Gray MJ, Tavares NK, Escalante-Semerena JC.	Mol Microbiol	10.1111/j.1365-2958.2008.06437.x	2008
Enzymology	Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.	Chenge JT, Duyet LV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW.	J Biol Chem	10.1074/jbc.m116.748822	2017
Metabolism	Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights.	Goto Y, Li B, Claesen J, Shi Y, Bibb MJ, van der Donk WA.	PLoS Biol	10.1371/journal.pbio.1000339	2010
Metabolism	Purification and reconstitution of the electron transport components for 6-deoxyerythronolide B hydroxylase, a cytochrome P-450 enzyme of macrolide antibiotic (erythromycin) biosynthesis.	Shafiee A, Hutchinson CR.	J Bacteriol	10.1128/jb.170.4.1548-1553.1988	1988
Phylogeny	Heterogeneity of mycolactones produced by clinical isolates of Mycobacterium ulcerans: implications for virulence.	Mve-Obiang A, Lee RE, Portaels F, Small PL.	Infect Immun	10.1128/iai.71.2.774-783.2003	2003
Enzymology	Isolation and characterization of a sulfur-regulated gene encoding a periplasmically localized protein with sequence similarity to rhodanese.	Laudenbach DE, Ehrhardt D, Green L, Grossman A.	J Bacteriol	10.1128/jb.173.9.2751-2760.1991	1991
	The architectures of iterative type I PKS and FAS.	Herbst DA, Townsend CA, Maier T.	Nat Prod Rep	10.1039/c8np00039e	2018
	Genetic and proteomic characterization of rpoB mutations and their effect on nematicidal activity in Photorhabdus luminescens LN2.	Qiu X, Yan X, Liu M, Han R.	PLoS One	10.1371/journal.pone.0043114	2012
Metabolism	Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.	Kuscer E, Coates N, Challis I, Gregory M, Wilkinson B, Sheridan R, Petkovic H.	J Bacteriol	10.1128/jb.00129-07	2007
	Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster.	Kawasaki T, Hayashi Y, Kuzuyama T, Furihata K, Itoh N, Seto H, Dairi T.	J Bacteriol	10.1128/jb.188.4.1236-1244.2006	2006
Metabolism	Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase.	Chen AY, Schnarr NA, Kim CY, Cane DE, Khosla C.	J Am Chem Soc	10.1021/ja058093d	2006
	Genomic characterization of mycobacteriophage Giles: evidence for phage acquisition of host DNA by illegitimate recombination.	Morris P, Marinelli LJ, Jacobs-Sera D, Hendrix RW, Hatfull GF.	J Bacteriol	10.1128/jb.01657-07	2008
	Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules.	Okada BK, Seyedsayamdost MR.	FEMS Microbiol Rev	10.1093/femsre/fuw035	2017
Metabolism	Biosynthesis of hexahydroxyperylenequinone melanin via oxidative aryl coupling by cytochrome P-450 in Streptomyces griseus.	Funa N, Funabashi M, Ohnishi Y, Horinouchi S.	J Bacteriol	10.1128/jb.187.23.8149-8155.2005	2005
Metabolism	Regulation of L-lactate utilization by the FadR-type regulator LldR of Corynebacterium glutamicum.	Georgi T, Engels V, Wendisch VF.	J Bacteriol	10.1128/jb.01147-07	2008
Metabolism	The gpsX gene encoding a glycosyltransferase is important for polysaccharide production and required for full virulence in Xanthomonas citri subsp. citri.	Li J, Wang N.	BMC Microbiol	10.1186/1471-2180-12-31	2012
Enzymology	Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe.	Davydov DR, Botchkareva AE, Davydova NE, Halpert JR.	Biophys J	10.1529/biophysj.104.058479	2005
Phylogeny	Phylogenetic distribution and membrane topology of the LytR-CpsA-Psr protein family.	Hubscher J, Luthy L, Berger-Bachi B, Stutzmann Meier P.	BMC Genomics	10.1186/1471-2164-9-617	2008
Metabolism	Enzymatic conversion of glucose to UDP-4-keto-6-deoxyglucose in Streptomyces spp.	Liu SY, Rosazza JP.	Appl Environ Microbiol	10.1128/aem.64.10.3972-3976.1998	1998
Metabolism	FtsW is a dispensable cell division protein required for Z-ring stabilization during sporulation septation in Streptomyces coelicolor.	Mistry BV, Del Sol R, Wright C, Findlay K, Dyson P.	J Bacteriol	10.1128/jb.00398-08	2008
	Production of the potent antibacterial polyketide erythromycin C in Escherichia coli.	Peiru S, Menzella HG, Rodriguez E, Carney J, Gramajo H.	Appl Environ Microbiol	10.1128/aem.71.5.2539-2547.2005	2005
Enzymology	Functional analysis of the carbohydrate-binding domains of Erwinia chrysanthemi Cel5 (Endoglucanase Z) and an Escherichia coli putative chitinase.	Simpson HD, Barras F.	J Bacteriol	10.1128/jb.181.15.4611-4616.1999	1999
Enzymology	Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium.	Belcher J, McLean KJ, Matthews S, Woodward LS, Fisher K, Rigby SEJ, Nelson DR, Potts D, Baynham MT, Parker DA, Leys D, Munro AW.	J Biol Chem	10.1074/jbc.m113.527325	2014
Metabolism	Three thioesterases are involved in the biosynthesis of phosphinothricin tripeptide in Streptomyces viridochromogenes Tü494.	Eys S, Schwartz D, Wohlleben W, Schinko E.	Antimicrob Agents Chemother	10.1128/aac.01053-07	2008
	The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster.	Lombo F, Brana AF, Mendez C, Salas JA.	J Bacteriol	10.1128/jb.181.2.642-647.1999	1999
Metabolism	Biosynthesis of the Pseudomonas polyketide coronafacic acid requires monofunctional and multifunctional polyketide synthase proteins.	Rangaswamy V, Jiralerspong S, Parry R, Bender CL.	Proc Natl Acad Sci U S A	10.1073/pnas.95.26.15469	1998
Metabolism	Role of the D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid.	Heaton MP, Neuhaus FC.	J Bacteriol	10.1128/jb.176.3.681-690.1994	1994
	Symbiosis-inspired approaches to antibiotic discovery.	Adnani N, Rajski SR, Bugni TS.	Nat Prod Rep	10.1039/c7np00009j	2017
Metabolism	Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.	McDaniel R, Thamchaipenet A, Gustafsson C, Fu H, Betlach M, Ashley G.	Proc Natl Acad Sci U S A	10.1073/pnas.96.5.1846	1999
Metabolism	Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.	Remsing LL, Garcia-Bernardo J, Gonzalez A, Kunzel E, Rix U, Brana AF, Bearden DW, Mendez C, Salas JA, Rohr J.	J Am Chem Soc	10.1021/ja0105156	2002
Metabolism	Evolution of xyloglucan-related genes in green plants.	Del Bem LE, Vincentz MG.	BMC Evol Biol	10.1186/1471-2148-10-341	2010
Metabolism	Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development.	Tschowri N, Schumacher MA, Schlimpert S, Chinnam NB, Findlay KC, Brennan RG, Buttner MJ.	Cell	10.1016/j.cell.2014.07.022	2014
Metabolism	Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.	Zhang X, Alemany LB, Fiedler HP, Goodfellow M, Parry RJ.	Antimicrob Agents Chemother	10.1128/aac.00717-07	2008
Metabolism	Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae.	Wilson DJ, Xue Y, Reynolds KA, Sherman DH.	J Bacteriol	10.1128/jb.183.11.3468-3475.2001	2001
Phylogeny	Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.	Jungmann V, Molnar I, Hammer PE, Hill DS, Zirkle R, Buckel TG, Buckel D, Ligon JM, Pachlatko JP.	Appl Environ Microbiol	10.1128/aem.71.11.6968-6976.2005	2005
	hrcA, encoding the repressor of the groEL genes in Streptomyces albus G, is associated with a second dnaJ gene.	Grandvalet C, Rapoport G, Mazodier P.	J Bacteriol	10.1128/jb.180.19.5129-5134.1998	1998
	Subtractive hybridization reveals a type I polyketide synthase locus specific to Mycobacterium ulcerans.	Jenkin GA, Stinear TP, Johnson PD, Davies JK.	J Bacteriol	10.1128/jb.185.23.6870-6882.2003	2003
Pathogenicity	Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.	Unemo M, Shafer WM.	Clin Microbiol Rev	10.1128/cmr.00010-14	2014
Metabolism	Characterization of a 12-kilodalton rhodanese encoded by glpE of Escherichia coli and its interaction with thioredoxin.	Ray WK, Zeng G, Potters MB, Mansuri AM, Larson TJ.	J Bacteriol	10.1128/jb.182.8.2277-2284.2000	2000
Metabolism	The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.	Lomovskaya N, Doi-Katayama Y, Filippini S, Nastro C, Fonstein L, Gallo M, Colombo AL, Hutchinson CR.	J Bacteriol	10.1128/jb.180.9.2379-2386.1998	1998
	Identification of site-specific recombination genes int and xis of the Rhizobium temperate phage 16-3.	Semsey S, Papp I, Buzas Z, Patthy A, Orosz L, Papp PP.	J Bacteriol	10.1128/jb.181.14.4185-4192.1999	1999
Metabolism	Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.	Wu J, Zaleski TJ, Valenzano C, Khosla C, Cane DE.	J Am Chem Soc	10.1021/ja055672+	2005
	Identification of genes in Xanthomonas campestris pv. vesicatoria induced during its interaction with tomato.	Tamir-Ariel D, Navon N, Burdman S.	J Bacteriol	10.1128/jb.00320-07	2007
	Identification and analysis of the balhimycin biosynthetic gene cluster and its use for manipulating glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908.	Pelzer S, Sussmuth R, Heckmann D, Recktenwald J, Huber P, Jung G, Wohlleben W.	Antimicrob Agents Chemother	10.1128/aac.43.7.1565	1999
	Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage.	Adao D, Gois AF, Pacheco RL, Pimentel CF, Riera R.	Cochrane Database Syst Rev	10.1002/14651858.cd013176.pub2	2023
	The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: organization and siderophore-dependent regulation.	Pelludat C, Rakin A, Jacobi CA, Schubert S, Heesemann J.	J Bacteriol	10.1128/jb.180.3.538-546.1998	1998
Metabolism	The Stigmatella aurantiaca homolog of Myxococcus xanthus high-mobility-group A-type transcription factor CarD: insights into the functional modules of CarD and their distribution in bacteria.	Cayuela ML, Elias-Arnanz M, Penalver-Mellado M, Padmanabhan S, Murillo FJ.	J Bacteriol	10.1128/jb.185.12.3527-3537.2003	2003
	Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold.	Workun GJ, Moquin K, Rothery RA, Weiner JH.	Microbiol Mol Biol Rev	10.1128/mmbr.00041-07	2008
	Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.	Liu W, Shen B.	Antimicrob Agents Chemother	10.1128/aac.44.2.382-392.2000	2000
	Characterization of a Brucella species 25-kilobase DNA fragment deleted from Brucella abortus reveals a large gene cluster related to the synthesis of a polysaccharide.	Vizcaino N, Cloeckaert A, Zygmunt MS, Fernandez-Lago L.	Infect Immun	10.1128/iai.69.11.6738-6748.2001	2001
Metabolism	P450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporium.	Syed K, Yadav JS.	Crit Rev Microbiol	10.3109/1040841x.2012.682050	2012
Metabolism	Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.	Lomovskaya N, Otten SL, Doi-Katayama Y, Fonstein L, Liu XC, Takatsu T, Inventi-Solari A, Filippini S, Torti F, Colombo AL, Hutchinson CR.	J Bacteriol	10.1128/jb.181.1.305-318.1999	1999
	The type I fatty acid and polyketide synthases: a tale of two megasynthases.	Smith S, Tsai SC.	Nat Prod Rep	10.1039/b603600g	2007
Pathogenicity	Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system.	Lee J, Jo DG, Park D, Chung HY, Mattson MP.	Pharmacol Rev	10.1124/pr.113.007757	2014
Enzymology	Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems.	Schweizer E, Hofmann J.	Microbiol Mol Biol Rev	10.1128/mmbr.68.3.501-517.2004	2004
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Metabolism	Identification and Characterization of a Novel N- and O-Glycosyltransferase from Saccharopolyspora erythraea.	Gutacker F, Schmidt-Bohli YI, Strobel T, Qiu D, Jessen H, Paululat T, Bechthold A	Molecules	10.3390/molecules25153400	2020
Metabolism	Two amino acids missing of MtrA resulted in increased erythromycin level and altered phenotypes in Saccharopolyspora erythraea.	Pan Q, Tong Y, Han YJ, Ye BC	Appl Microbiol Biotechnol	10.1007/s00253-019-09825-9	2019
Metabolism	Precursor Supply for Erythromycin Biosynthesis: Engineering of Propionate Assimilation Pathway Based on Propionylation Modification.	You D, Wang MM, Yin BC, Ye BC	ACS Synth Biol	10.1021/acssynbio.8b00396	2019
Metabolism	Metabolic Engineering Strategies Based on Secondary Messengers (p)ppGpp and C-di-GMP To Increase Erythromycin Yield in Saccharopolyspora erythraea.	Xu Z, You D, Tang LY, Zhou Y, Ye BC	ACS Synth Biol	10.1021/acssynbio.8b00372	2019
Metabolism	Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea.	Karnicar K, Drobnak I, Petek M, Magdevska V, Horvat J, Vidmar R, Baebler S, Rotter A, Jamnik P, Fujs S, Turk B, Fonovic M, Gruden K, Kosec G, Petkovic H	Microb Cell Fact	10.1186/s12934-016-0496-5	2016
Enzymology	Lysine epsilon-aminotransferases: kinetic constants, substrate specificities, and the variation in active site residues.	Seo JH, Kim EM, Chae A, Kim BG	Enzyme Microb Technol	10.1016/j.enzmictec.2015.12.001	2015
Biotechnology	Strain improvement and optimization studies for enhanced production of erythromycin in bagasse based medium using Saccharopolyspora erythraea MTCC 1103.	Subathra Devi C, Saini A, Rastogi S, Jemimah Naine S, Mohanasrinivasan V	3 Biotech	10.1007/s13205-013-0186-5	2013
Metabolism	Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field.	Chen D, Feng J, Huang L, Zhang Q, Wu J, Zhu X, Duan Y, Xu Z	PLoS One	10.1371/journal.pone.0108129	2014
Metabolism	Characterization of new class III lantibiotics--erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing.	Voller GH, Krawczyk JM, Pesic A, Krawczyk B, Nachtigall J, Sussmuth RD	Chembiochem	10.1002/cbic.201200118	2012
Genetics	Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain.	Peano C, Tala A, Corti G, Pasanisi D, Durante M, Mita G, Bicciato S, De Bellis G, Alifano P	Microb Cell Fact	10.1186/1475-2859-11-32	2012
Metabolism	Identifying modules of coexpressed transcript units and their organization of Saccharopolyspora erythraea from time series gene expression profiles.	Chang X, Liu S, Yu YT, Li YX, Li YY	PLoS One	10.1371/journal.pone.0012126	2010
Phenotype	Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production.	Carata E, Peano C, Tredici SM, Ferrari F, Tala A, Corti G, Bicciato S, De Bellis G, Alifano P	Microb Cell Fact	10.1186/1475-2859-8-18	2009
Metabolism	Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.	Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H	Proc Natl Acad Sci U S A	10.1073/pnas.0802312105	2008
	Complete gene expression profiling of Saccharopolyspora erythraea using GeneChip DNA microarrays.	Peano C, Bicciato S, Corti G, Ferrari F, Rizzi E, Bonnal RJ, Bordoni R, Albertini A, Bernardi LR, Donadio S, De Bellis G	Microb Cell Fact	10.1186/1475-2859-6-37	2007
	[Development of a system of plasmid transfer in the strains Streptomyces avermitilis ATCC 31272 and Saccharopolyspora erythraea ATCC 11635 by the method of intergeneric conjugation].	Voeikova TA, Emel'ianova LK, Kudriavtseva EA	Genetika		2003
Biotechnology	Decreasing the hyphal branching rate of Saccharopolyspora erythraea NRRL 2338 leads to increased resistance to breakage and increased antibiotic production.	Wardell JN, Stocks SM, Thomas CR, Bushell ME	Biotechnol Bioeng	10.1002/bit.10210	2002
Enzymology	A unique chitinase with dual active sites and triple substrate binding sites from the hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1.	Tanaka T, Fujiwara S, Nishikori S, Fukui T, Takagi M, Imanaka T	Appl Environ Microbiol	10.1128/AEM.65.12.5338-5344.1999	1999
Phylogeny	Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity.	Pacey MS, Dirlam JP, Geldart RW, Leadlay PF, McArthur HA, McCormick EL, Monday RA, O'Connell TN, Staunton J, Winchester TJ	J Antibiot (Tokyo)	10.7164/antibiotics.51.1029	1998
Metabolism	Physical-genetic map of the erythromycin-producing organism Saccharopolyspora erythraea.	Reeves AR, Post DA, Vanden Boom TJ	Microbiology (Reading)	10.1099/00221287-144-8-2151	1998
Metabolism	Biosynthesis of erythromycin: origin of the methyl protons.	Kajiwara M, Uegaki R, Iida K, Wada Y	Chem Pharm Bull (Tokyo)	10.1248/cpb.42.1522	1994
Phylogeny	Distribution of oxoacyl synthase homology sequences within Streptomyces DNA.	Kuczek K, Mordarski M, Goodfellow M	FEMS Microbiol Lett	10.1111/j.1574-6968.1994.tb06847.x	1994
Enzymology	[Plasmid pSE21 of Streptomyces erythraeus strains].	Grigor'ev AE, Belova TS, Naidenova MI, Danilenko VN	Antibiot Khimioter		1990
	Characterization of bacteriophage phi C69 of Saccharopolyspora erythraea and demonstration of heterologous actinophage propagation by transfection of Streptomyces and Saccharopolyspora.	Katz L, Chiang SJ, Tuan JS, Zablen LB	J Gen Microbiol	10.1099/00221287-134-7-1765	1988
Genetics	Site-specific integration in Saccharopolyspora erythraea and multisite integration in Streptomyces lividans of actinomycete plasmid pSE101.	Brown DP, Chiang SJ, Tuan JS, Katz L	J Bacteriol	10.1128/jb.170.5.2287-2295.1988	1988
Genetics	Microvirga massiliensis sp. nov., the human commensal with the largest genome.	Caputo A, Lagier JC, Azza S, Robert C, Mouelhi D, Fournier PE, Raoult D.	Microbiologyopen	10.1002/mbo3.329	2016
Phylogeny	Sciscionella marina gen. nov., sp. nov., a marine actinomycete isolated from a sediment in the northern South China Sea.	Tian XP, Zhi XY, Qiu YQ, Zhang YQ, Tang SK, Xu LH, Zhang S, Li WJ	Int J Syst Evol Microbiol	10.1099/ijs.0.001982-0	2009