Amycolatopsis saalfeldensis (DSM 44993, JCM 14909, NRRL B-24474)

Name: Amycolatopsis saalfeldensis (DSM 44993, JCM 14909, NRRL B-24474)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 13260

Type strain

Strain Designation 2406-001

Culture col. no. DSM 44993 JCM 14909 NRRL B-24474 HKI 0457 2406-001 2 more

NCBI tax ID(s) 394193

Special Collections DSMZ JCM Wink compendium Literature strains JMRC

History DSMZ <- I. Groth; HKI 0457 <- Ch. Weigel JCM <-- DSM 44993 <-- I. Groth HKI 0457 <-- Ch. Weigel.

Links

Amycolatopsis saalfeldensis 2406-001 is an aerobe, Gram-positive, rod-shaped bacterium that builds an aerial mycelium and was isolated from Feengrotten, rock wall centralgrotta, 2nd floor.

Gram-positive rod-shaped aerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 297474

DSM 44993,NRRL B-24474,JCM 14909

@ref 20215

Last LPSN update 2026-05-29 08:28:00

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Pseudonocardiales

Family Pseudonocardiaceae

Genus Amycolatopsis

Species Amycolatopsis saalfeldensis

Full scientific name Amycolatopsis saalfeldensis Carlsohn et al. 2007

BacDive ID	Other strains from **Amycolatopsis saalfeldensis** (4)	Type strain
104714	A. saalfeldensis SF008658,
178621	A. saalfeldensis 2409-015, ST031364
178622	A. saalfeldensis 2410-017, ST031365
178919	A. saalfeldensis 11-JE-04, ST036014

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
32064	positive	rod-shaped
125439	positive			98.347

Colony morphology

@ref	Colony color	Incubation period	Medium used
20154	Beige (1001)	10-14 days	ISP 2
20154	Beige (1001)	10-14 days	ISP 3
20154	Beige (1001)	10-14 days	ISP 4
20154	Beige (1001)	10-14 days	ISP 5
20154	Beige (1001)	10-14 days	ISP 6
20154	Beige (1001)	10-14 days	ISP 7

Multicellular morphology

@ref	Complex name	Complex color	Medium name
20154	Aerial Mycelium	Cream	ISP 2
20154	Aerial Mycelium	Cream	ISP 3
20154	Aerial Mycelium	Cream	ISP 4
20154			ISP 5
20154			ISP 6
20154	Aerial Mycelium	Cream	ISP 7

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
12225	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)	Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
20154	ISP 2		Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
20154	ISP 3		Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
20154	ISP 4		Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
20154	ISP 5		Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
20154	ISP 6		Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
20154	ISP 7		Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes

Culture temp

@ref	Growth	Type	Temperature (°C)
12225	positive	growth	28
20154	positive	optimum	28
32064	positive	growth	10-42
32064	positive	optimum	27.5
67770	positive	growth	28

Culture pH

@ref	Ability	Type	PH
32064	positive	optimum	6.25
32064	positive	growth	4.5-8.0

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
32064	aerobe
125439	obligate aerobe	98.408

Halophily

@ref	Salt	Growth	Tested relation	Concentration
32064	NaCl	positive	growth	0.0-2.0 %
32064	NaCl	positive	optimum	2 %

Observation

67770

Observationquinones: MK-9(H₄)

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
32064	30089 ChEBI	acetate	+	carbon source
68369	17128 ChEBI	adipate	-	assimilation	from API 20NE
32064	22599 ChEBI	arabinose	+	carbon source
68369	29016 ChEBI	arginine	-	hydrolysis	from API 20NE
32064	16947 ChEBI	citrate	+	carbon source
68369	17634 ChEBI	D-glucose	-	assimilation	from API 20NE
68369	17634 ChEBI	D-glucose	-	fermentation	from API 20NE
68369	16899 ChEBI	D-mannitol	-	assimilation	from API 20NE
68369	16024 ChEBI	D-mannose	-	assimilation	from API 20NE
68369	27689 ChEBI	decanoate	-	assimilation	from API 20NE
32064	4853 ChEBI	esculin	+	hydrolysis
32064	28757 ChEBI	fructose	+	carbon source
68369	5291 ChEBI	gelatin	-	hydrolysis	from API 20NE
68369	24265 ChEBI	gluconate	-	assimilation	from API 20NE
32064	17234 ChEBI	glucose	+	carbon source
68369	30849 ChEBI	L-arabinose	-	assimilation	from API 20NE
32064	25115 ChEBI	malate	+	carbon source
68369	25115 ChEBI	malate	-	assimilation	from API 20NE
68369	17306 ChEBI	maltose	-	assimilation	from API 20NE
32064	29864 ChEBI	mannitol	+	carbon source
32064	506227 ChEBI	N-acetylglucosamine	+	carbon source
68369	59640 ChEBI	N-acetylglucosamine	-	assimilation	from API 20NE
68369	17632 ChEBI	nitrate	-	reduction	from API 20NE
32064	26546 ChEBI	rhamnose	+	carbon source
32064	30031 ChEBI	succinate	+	carbon source
32064	17992 ChEBI	sucrose	+	carbon source
68369	27897 ChEBI	tryptophan	-	energy source	from API 20NE
32064	53426 ChEBI	tween 80	+	carbon source
68369	16199 ChEBI	urea	-	hydrolysis	from API 20NE
32064	18222 ChEBI	xylose	+	carbon source

Metabolite production

@ref	Chebi-ID	Metabolite	Production
32064	16136 ChEBI	hydrogen sulfide
68369	35581 ChEBI	indole		from API 20NE

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68369	35581 ChEBI	indole	-	from API 20NE

Enzymes

@ref	Value	Activity	Ec
32064	acid phosphatase	+	3.1.3.2
32064	alkaline phosphatase	+	3.1.3.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68369	arginine dihydrolase	-	3.5.3.6	from API 20NE
68382	beta-galactosidase	-	3.2.1.23	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68382	cystine arylamidase	-	3.4.11.3	from API zym
32064	cytochrome oxidase	+	1.9.3.1
32064	gelatinase	+
68369	gelatinase	-		from API 20NE
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	trypsin	-	3.4.21.4	from API zym
32064	urease	+	3.5.1.5
68369	urease	-	3.5.1.5	from API 20NE
68382	valine arylamidase	-		from API zym

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	valine metabolism	100	9 of 9
66794	enterobactin biosynthesis	100	3 of 3
66794	4-hydroxymandelate degradation	100	9 of 9
66794	ethanol fermentation	100	2 of 2
66794	threonine metabolism	100	10 of 10
66794	dTDPLrhamnose biosynthesis	100	8 of 8
66794	cardiolipin biosynthesis	100	7 of 7
66794	Entner Doudoroff pathway	100	10 of 10
66794	glycogen metabolism	100	5 of 5
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	kanosamine biosynthesis II	100	2 of 2
66794	3-chlorocatechol degradation	100	5 of 5
66794	palmitate biosynthesis	100	22 of 22
66794	resorcinol degradation	100	2 of 2
66794	acetate fermentation	100	4 of 4
66794	butanoate fermentation	100	4 of 4
66794	lipoate biosynthesis	100	5 of 5
66794	starch degradation	100	10 of 10
66794	methylglyoxal degradation	100	5 of 5
66794	biotin biosynthesis	100	4 of 4
66794	L-lactaldehyde degradation	100	3 of 3
66794	ppGpp biosynthesis	100	4 of 4
66794	propanol degradation	100	7 of 7
66794	pentose phosphate pathway	100	11 of 11
66794	octane oxidation	100	3 of 3
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	suberin monomers biosynthesis	100	2 of 2
66794	folate polyglutamylation	100	1 of 1
66794	aerobactin biosynthesis	100	1 of 1
66794	taurine degradation	100	1 of 1
66794	coenzyme A metabolism	100	4 of 4
66794	sulfopterin metabolism	100	4 of 4
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	isoleucine metabolism	100	8 of 8
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	formaldehyde oxidation	100	3 of 3
66794	glycine betaine biosynthesis	100	5 of 5
66794	vitamin K metabolism	100	5 of 5
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	cellulose degradation	100	5 of 5
66794	reductive acetyl coenzyme A pathway	100	7 of 7
66794	adipate degradation	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	ribulose monophosphate pathway	100	2 of 2
66794	heme metabolism	92.86	13 of 14
66794	citric acid cycle	92.86	13 of 14
66794	tetrahydrofolate metabolism	92.86	13 of 14
66794	phenylalanine metabolism	92.31	12 of 13
66794	leucine metabolism	92.31	12 of 13
66794	proline metabolism	90.91	10 of 11
66794	phenol degradation	90	18 of 20
66794	propionate fermentation	90	9 of 10
66794	alanine metabolism	89.66	26 of 29
66794	serine metabolism	88.89	8 of 9
66794	CO2 fixation in Crenarchaeota	88.89	8 of 9
66794	degradation of hexoses	88.89	16 of 18
66794	NAD metabolism	88.89	16 of 18
66794	chorismate metabolism	88.89	8 of 9
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	molybdenum cofactor biosynthesis	88.89	8 of 9
66794	purine metabolism	88.3	83 of 94
66794	glycolysis	88.24	15 of 17
66794	vitamin B12 metabolism	88.24	30 of 34
66794	ketogluconate metabolism	87.5	7 of 8
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	aclacinomycin biosynthesis	85.71	6 of 7
66794	urea cycle	84.62	11 of 13
66794	methionine metabolism	84.62	22 of 26
66794	tryptophan metabolism	84.21	32 of 38
66794	pyrimidine metabolism	82.22	37 of 45
66794	degradation of pentoses	82.14	23 of 28
66794	glutamate and glutamine metabolism	82.14	23 of 28
66794	cholesterol biosynthesis	81.82	9 of 11
66794	metabolism of disaccharids	81.82	9 of 11
66794	myo-inositol biosynthesis	80	8 of 10
66794	factor 420 biosynthesis	80	4 of 5
66794	gallate degradation	80	4 of 5
66794	flavin biosynthesis	80	12 of 15
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	arginine metabolism	79.17	19 of 24
66794	photosynthesis	78.57	11 of 14
66794	glutathione metabolism	78.57	11 of 14
66794	allantoin degradation	77.78	7 of 9
66794	d-mannose degradation	77.78	7 of 9
66794	non-pathway related	76.32	29 of 38
66794	degradation of sugar acids	76	19 of 25
66794	histidine metabolism	75.86	22 of 29
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	CMP-KDO biosynthesis	75	3 of 4
66794	gluconeogenesis	75	6 of 8
66794	cyclohexanol degradation	75	3 of 4
66794	degradation of aromatic, nitrogen containing compounds	75	9 of 12
66794	glycogen biosynthesis	75	3 of 4
66794	lipid metabolism	74.19	23 of 31
66794	3-phenylpropionate degradation	73.33	11 of 15
66794	cysteine metabolism	72.22	13 of 18
66794	tyrosine metabolism	71.43	10 of 14
66794	ubiquinone biosynthesis	71.43	5 of 7
66794	4-hydroxyphenylacetate degradation	70	7 of 10
66794	polyamine pathway	69.57	16 of 23
66794	vitamin B1 metabolism	69.23	9 of 13
66794	oxidative phosphorylation	69.23	63 of 91
66794	degradation of sugar alcohols	68.75	11 of 16
66794	androgen and estrogen metabolism	68.75	11 of 16
66794	cyanate degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	methane metabolism	66.67	2 of 3
66794	IAA biosynthesis	66.67	2 of 3
66794	lysine metabolism	66.67	28 of 42
66794	selenocysteine biosynthesis	66.67	4 of 6
66794	carotenoid biosynthesis	63.64	14 of 22
66794	ascorbate metabolism	63.64	14 of 22
66794	d-xylose degradation	63.64	7 of 11
66794	C4 and CAM-carbon fixation	62.5	5 of 8
66794	carnitine metabolism	62.5	5 of 8
66794	isoprenoid biosynthesis	61.54	16 of 26
66794	sulfate reduction	61.54	8 of 13
66794	phosphatidylethanolamine bioynthesis	61.54	8 of 13
66794	glycine metabolism	60	6 of 10
66794	metabolism of amino sugars and derivatives	60	3 of 5
66794	bile acid biosynthesis, neutral pathway	58.82	10 of 17
66794	benzoyl-CoA degradation	57.14	4 of 7
66794	arachidonic acid metabolism	55.56	10 of 18
66794	daunorubicin biosynthesis	55.56	5 of 9
66794	nitrate assimilation	55.56	5 of 9
66794	quinate degradation	50	1 of 2
66794	vitamin E metabolism	50	2 of 4
66794	lactate fermentation	50	2 of 4
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	toluene degradation	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	sphingosine metabolism	50	3 of 6
66794	coenzyme M biosynthesis	50	5 of 10
66794	pantothenate biosynthesis	50	3 of 6
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	vitamin B6 metabolism	45.45	5 of 11
66794	D-cycloserine biosynthesis	40	2 of 5
66794	arachidonate biosynthesis	40	2 of 5
66794	creatinine degradation	40	2 of 5
66794	hydrogen production	40	2 of 5
66794	elloramycin biosynthesis	40	2 of 5
66794	phenylpropanoid biosynthesis	38.46	5 of 13
66794	lipid A biosynthesis	33.33	3 of 9
66794	sulfoquinovose degradation	33.33	1 of 3
66794	methanogenesis from CO2	33.33	4 of 12
66794	chlorophyll metabolism	33.33	6 of 18
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	catecholamine biosynthesis	25	1 of 4
66794	alginate biosynthesis	25	1 of 4

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
20154	not determinedn.d.	+	+	+	-	+	-	-	-	-	+	+	-	-	-	+	+	+	-	-
12225	-	+	-	-	-	+	-	-	-	-	+/-	+/-	-	-	-	-	-	+	+/-	-

API 20NE

@ref	Reduction of nitratesNO3	TRP	GLU_ Ferm	ADH (Arg)	URE	ESC	GEL	PNPG	GLU_ Assim	ARA	MNE	MAN	NAG	MAL	GNT	CAP	ADI	MLT	CIT	PAC	OX
12225	-	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	not determinedn.d.

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Geologic

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent	Sampling date
12225	Feengrotten, rock wall centralgrotta, 2nd floor	Thuringia, Saalfeld	Germany	DEU	Europe
67770	Acidic and heavy-metal-containing rocks in the central grotto of the medieval alum slate mine Feengrotten	Saalfeld, Thuringia	Germany	DEU	Europe
20216		Saalfeld Fairy Grottoes/Saalfelder Feengrotten, Germany	Germany	DEU	Europe	2004-05-25

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
12225	1	Risk group (German classification) According to TRBA 466
20154	1

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	IMG-taxon 2634166333 annotated assembly for Amycolatopsis saalfeldensis DSM 44993	scaffold	GCA_900110575	394193.4	2634166333	394193	60.15

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
12225	Amycolatopsis saalfeldensis strain 2406-001 16S ribosomal RNA gene, partial sequence	DQ792500	1448	394193
124043	Amycolatopsis saalfeldensis strain 2410-017 16S ribosomal RNA gene, partial sequence.	DQ792501	1448	394193
124043	Amycolatopsis saalfeldensis strain 2410-017 16S ribosomal RNA gene, partial sequence.	DQ792502	1457	394193

GC content

@ref	GC-content (mol%)	Method
67770	71	genome sequence analysis

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: IMG-taxon 2634166333 annotated assembly for Amycolatopsis saalfeldensis DSM 44993
BV-BRC: 394193.4

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	98.41	no
125439	motility	BacteriaNetⓘ	no	89.24	no
125439	gram_stain	BacteriaNetⓘ	positive	98.35	no
125439	spore_formation	BacteriaNetⓘ	yes	81.69	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Amycolatopsis saalfeldensis strain DSM 44993
PATRIC: 394193.4

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	87.13	yes
125438	anaerobic	anaerobicⓘ	no	94.75	yes
125438	spore-forming	spore-formingⓘ	yes	77.51	no
125438	aerobic	aerobicⓘ	yes	89.60	yes
125438	thermophilic	thermophileⓘ	no	96.49	yes
125438	flagellated	motile2+ⓘ	no	88.50	yes

Literature

Topic	Title	Authors	Journal	DOI	Year
	Complete Genome Sequences of Two Novel Species from the Pseudonocardiaceae Family Isolated from the Persian Gulf.	Safaei N, Bunk B, Sproer C, Wink J, Mast Y.	Microbiol Resour Announc	10.1128/mra.00918-21	2021
Phylogeny	Bacteria from the Amycolatopsis genus associated with a toxic bird secrete protective secondary metabolites.	Seibel E, Um S, Bodawatta KH, Komor AJ, Decker T, Fricke J, Murphy R, Maiah G, Iova B, Maus H, Schirmeister T, Jonsson KA, Poulsen M, Beemelmanns C.	Nat Commun	10.1038/s41467-024-52316-3	2024
Metabolism	Biosynthesis of the Thiopeptins and Identification of an F₄₂₀H₂-Dependent Dehydropiperidine Reductase.	Ichikawa H, Bashiri G, Kelly WL.	J Am Chem Soc	10.1021/jacs.8b04238	2018
	Targeted Isolation of Saalfelduracin B-D from Amycolatopsis saalfeldensis Using LC-MS/MS-Based Molecular Networking.	Um S, Seibel E, Schalk F, Balluff S, Beemelmanns C.	J Nat Prod	10.1021/acs.jnatprod.0c01027	2021
Genetics	Targeted Large-Scale Genome Mining and Candidate Prioritization for Natural Product Discovery.	Malit JJL, Leung HYC, Qian PY.	Mar Drugs	10.3390/md20060398	2022
Metabolism	Biosynthesis and Chemical Applications of Thioamides.	Mahanta N, Szantai-Kis DM, Petersson EJ, Mitchell DA.	ACS Chem Biol	10.1021/acschembio.8b01022	2019
Genetics	Revisiting the Taxonomic Status of the Biomedically and Industrially Important Genus Amycolatopsis, Using a Phylogenomic Approach.	Sangal V, Goodfellow M, Blom J, Tan GYA, Klenk HP, Sutcliffe IC.	Front Microbiol	10.3389/fmicb.2018.02281	2018
Genetics	Challenges and advances in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs).	Zhong Z, He B, Li J, Li YX.	Synth Syst Biotechnol	10.1016/j.synbio.2020.06.002	2020
Phylogeny	Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics.	Schwalen CJ, Hudson GA, Kille B, Mitchell DA.	J Am Chem Soc	10.1021/jacs.8b03896	2018
	Recent Advances in Discovery, Bioengineering, and Bioactivity-Evaluation of Ribosomally Synthesized and Post-translationally Modified Peptides.	Zhong G, Wang ZJ, Yan F, Zhang Y, Huo L.	ACS Bio Med Chem Au	10.1021/acsbiomedchemau.2c00062	2023
	Actinobacterial diversity in limestone deposit sites in Hundung, Manipur (India) and their antimicrobial activities.	Nimaichand S, Devi AM, Tamreihao K, Ningthoujam DS, Li WJ.	Front Microbiol	10.3389/fmicb.2015.00413	2015
Metabolism	A new benzofuran glycoside and indole alkaloids from a sponge-associated rare actinomycete, Amycolatopsis sp.	Kwon Y, Kim SH, Shin Y, Bae M, Kim BY, Lee SK, Oh KB, Shin J, Oh DC.	Mar Drugs	10.3390/md12042326	2014
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Phylogeny	Amycolatopsis saalfeldensis sp. nov., a novel actinomycete isolated from a medieval alum slate mine.	Carlsohn MR, Groth I, Tan GYA, Schutze B, Saluz HP, Munder T, Yang J, Wink J, Goodfellow M	Int J Syst Evol Microbiol	10.1099/ijs.0.64903-0	2007

References

#12225	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 44993
#20154	Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20216	Curators of the JMRC: Jena Microbial Resource Collection (JMRC):
#28311	IJSEM 1640 2007 ( DOI 10.1099/ijs.0.64903-0 , PubMed 17625209 )
#32064	Barberan A, Caceres Velazquez H, Jones S, Fierer N.: Hiding in Plain Sight: Mining Bacterial Species Records for Phenotypic Trait Information. mSphere 2: 2017 ( DOI 10.1128/mSphere.00237-17 , PubMed 28776041 ) - originally annotated from #28311
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68369	Automatically annotated from API 20NE .
#68382	Automatically annotated from API zym .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Amycolatopsis saalfeldensis (DSM 44993, JCM 14909, NRRL B-24474)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Multicellular morphology

Culture and growth conditions

Culture medium

Culture temp

Culture pH

Physiology and metabolism

Oxygen tolerance

Halophily

Observation

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

Pathway annotation

API zym

API 20NE

Isolation, sampling and environmental information

Isolation source categories

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_900110575

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

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