Amycolatopsis mediterranei (DSM 43304, ATCC 13685, CBS 121.63)

Name: Amycolatopsis mediterranei (DSM 43304, ATCC 13685, CBS 121.63)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 13220

Type strain

Strain Designation Lepetit ME/83, Lepetit ME83/973, Schering 368

Culture col. no. DSM 43304 ATCC 13685 CBS 121.63 CBS 716.72 DSM 40501 32 more

NCBI tax ID(s) 33910

Special Collections DSMZ CCUG JCM KCTC CIP Wink compendium JMRC

History DSMZ <- K. Kieslich, Schering 368 <- ATCC <- Lepetit Labs. ME 83/973 (Streptomyces mediterranei) JCM <-- KCC S-0789 <-- IFO 13415 <-- SAJ <-- ISP 5501 <-- ATCC 13685 <-- Lepetit ME/83. CIP <- 2001, CCUG <- 2000, DSMZ <- K. Kieslich: strain Schering 368 <- ATCC <- Lepetit Labs: strain ME 83/973, Streptomyces mediterranei

Links

Amycolatopsis mediterranei Lepetit ME/83 is an aerobe, Gram-positive, filament-shaped bacterium that produces antibiotic compounds and was isolated from soil.

antibiotic compound production Gram-positive filament-shaped aerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 45544

LMG 5978,PCM 2320,ATCC 13685,IFO 13415,IMET 7651,NRRL B-3240,DSM 43304,DSM 40501,JCM 4789,NCIB 9613,VKM Ac-798,CCRC 12440,CCUG 11119,IFO 13142,NCIMB 9613,CBS 121.63,CBS 716.72,KCTC 1739,CIP 107074,CCUG 43144,NBRC 13142,NBRC 13415,BCRC 12440,NBIMCC 3395,NCIM 5008,CGMCC 4.1213,ATCC13

@ref 20215

Last LPSN update 2026-05-29 08:27:59

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Pseudonocardiales

Family Pseudonocardiaceae

Genus Amycolatopsis

Species Amycolatopsis mediterranei

Full scientific name Amycolatopsis mediterranei (Margalith and Beretta 1960) Lechevalier et al. 1986

Synonyms (3)

"Streptomyces mediterranei"
Nocardia mediterranei
Nocardia mediterranea

BacDive ID	Other strains from **Amycolatopsis mediterranei** (6)	Type strain
13219	A. mediterranei DSM 40773, LBG A-3136
13221	A. mediterranei Lepetit S 955, S 955, DSM 46096, ATCC 21411, ...
100031	A. mediterranei STI07582(IMET), 1136-53,
100032	A. mediterranei STI07652, IMET 07690, Mer MER6468
100033	A. mediterranei STI07667(IMET), M18,
100034	A. mediterranei STI07670(IMET), RS/20,

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
120876	positive	filament-shaped
125439	positive			98.289

Colony morphology

120876

Hemolysis ability0

Multimedia

@ref:	10944
multimedia content:	DSM_43304.jpg
multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_43304.jpg
caption:	Medium 65 28°C
intellectual property rights:	© Leibniz-Institut DSMZ
manual_annotation:	1

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
10944	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)	Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
39652	MEDIUM 57 - for Streptomyces, Nocardioides, Lentzea albidocapillata and Streptoverticillium reticulum		Distilled water make up to (1000.000 ml);Agar (15.000 g);Glucose (4.000g);Yeast extract (4.000 g);Malt extract (10.000 g);Calcium carbonate (2.000 g)
120876	CIP Medium 57	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
10944	positive	growth	28
39652	positive	growth	30
55691	positive	growth	30
67770	positive	growth	28
120876	positive	growth	25-37
120876	negative	growth	10
120876	negative	growth	41
120876	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
55691	aerobe
120876	obligate aerobe
125439	obligate aerobe	99.766

Compound production

@ref	Compound
10944	rifamycin SV
20216	Rifamycin SV

Halophily

@ref	Salt	Growth	Tested relation	Concentration
120876	NaCl	positive	growth	0-4 %
120876	NaCl		growth	6 %
120876	NaCl		growth	8 %
120876	NaCl		growth	10 %

Observation

67770

Observationquinones: MK-9(H₄)

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
120876	16947 ChEBI	citrate	-	carbon source
120876	4853 ChEBI	esculin	+	hydrolysis
120876	606565 ChEBI	hippurate	+	hydrolysis
120876	17632 ChEBI	nitrate	-	reduction
120876	17632 ChEBI	nitrate	-	respiration
120876	16301 ChEBI	nitrite	-	reduction

Antibiotic resistance

@ref	Metabolite	Is sensitive	Is resistant
120876	0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)

Metabolite production

@ref	Chebi-ID	Metabolite	Production
120876	35581 ChEBI	indole
67770	26580 ChEBI	rifamycin

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test
120876	15688 ChEBI	acetoin	-
120876	17234 ChEBI	glucose		-

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
120876	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	+	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	+	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
120876	amylase	-
68382	beta-galactosidase	+	3.2.1.23	from API zym
120876	beta-galactosidase	+	3.2.1.23
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
120876	caseinase	+	3.4.21.50
120876	catalase	+	1.11.1.6
68382	cystine arylamidase	+	3.4.11.3	from API zym
120876	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
120876	gamma-glutamyltransferase	+	2.3.2.2
120876	gelatinase	+/-
120876	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
120876	lipase	-
68382	lipase (C 14)	-		from API zym
120876	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
120876	ornithine decarboxylase	-	4.1.1.17
120876	oxidase	-
120876	phenylalanine ammonia-lyase	-	4.3.1.24
68382	trypsin	+	3.4.21.4	from API zym
120876	tryptophan deaminase	-
120876	tween esterase	-
120876	urease	+	3.5.1.5
68382	valine arylamidase	+		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
120876	-	+	+	+	-	+	+	+	+	+	+	+	+	+	-	+	-	+	-	-

API biotype100

@ref	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
120876	not determinedn.d.	+	+	+	+	+	-	-	+	-	+	+	-	+	+	-	+	+	-	+	+	+	+	-	+	+	+	+	-	-	-	+	+	+	+	-	-	-	-	-	+	-	-	-	+	-	-	-	-	-	+	+	+	+	-	+	-	-	-	-	+	+	-	+	-	+	+	+	-	-	+	+	+	-	+	+	+	-	-	-	-	-	-	-	-	-	-	+	-	-	+	+	+	+	-	-	-	+	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Soil

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
10944	soil
55691	Soil
67770	Soil	St. Raphael	France	FRA	Europe
120876	Environment, Soil		France	FRA	Europe

Taxonmaps

69479

Global distribution of 16S sequence AJ293754 (>99% sequence identity) for Amycolatopsis from Microbeatlas

Aquatic Samples	156
Soil Samples	4583
Animal Samples	306
Plant Samples	815
Total Samples	5860

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
10944	1	Risk group (German classification) According to TRBA 466
19565	1	Risk group (German classification) According to TRBA 466
120876	1	Risk group (French classification) According to TRBA 466

Phages

@ref	Name	Strain number
124042	Amycolatopsis phage W2	DSM 43304
124042	Amycolatopsis phage W4	DSM 43304

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM22094v1 assembly for Amycolatopsis mediterranei S699	complete	GCA_000220945	713604.4	2511231181	713604	97.89
66792	ASM2601784v1 assembly for Amycolatopsis mediterranei ISP5501	chromosome	GCA_026017845	33910.16		33910	69.41
124043	ASM4265660v1 assembly for Amycolatopsis mediterranei CCUG 43144	scaffold	GCA_042656605			33910	44.54

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Amycolatopsis mediterranei partial 16S rRNA gene, strain IMSNU 20056T	AJ293754	1488	33910
20218	Amycolatopsis mediterranei gene for 16S ribosomal RNA, partial sequence, strain: JCM 4789	D44364	120	33910
20218	Amycolatopsis mediterranei strain KCTC 1739T 16S ribosomal RNA gene, partial sequence	AY125600	1413	33910
20218	Amycolatopsis mediterranei strain NRRL B-3240 16S ribosomal RNA gene, partial sequence	AY184424	1482	33910
67770	A.mediterranei (DSM 13685) 16S ribosomal RNA (partial)	X76957	1426	33910

GC content

@ref	GC-content (mol%)	Method
67770	67-69	thermal denaturation, midpoint method (Tm)
67770	71.3	genome sequence analysis
67770	70	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM22094v1 assembly for Amycolatopsis mediterranei S699
NCBI: GCA_000220945

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	gram_stain	BacteriaNetⓘ	positive	98.29	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.77	no
125439	motility	BacteriaNetⓘ	no	83.63	no
125439	spore_formation	BacteriaNetⓘ	yes	74.05	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Looking Back to Amycolatopsis: History of the Antibiotic Discovery and Future Prospects.	Kisil OV, Efimenko TA, Efremenkova OV.	Antibiotics (Basel)	10.3390/antibiotics10101254	2021
Enzymology	The genus Amycolatopsis: Indigenous plasmids, cloning vectors and gene transfer systems.	Malhotra S, Lal R.	Indian J Microbiol	10.1007/s12088-007-0003-0	2007
Genetics	Genetics and Genomics of the Genus Amycolatopsis.	Kumari R, Singh P, Lal R.	Indian J Microbiol	10.1007/s12088-016-0590-8	2016
Metabolism	Novel assay for screening rifamycin B-producing mutants.	Vohra RM.	Appl Environ Microbiol	10.1128/aem.58.1.403-404.1992	1992
Metabolism	Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved conditions for expression of secondary metabolites from actinomycetes.	Zahn JA, Higgs RE, Hilton MD.	Appl Environ Microbiol	10.1128/aem.67.1.377-386.2001	2001
	Exploring the Potential of Halotolerant Actinomycetes from Rann of Kutch, India: A Study on the Synthesis, Characterization, and Biomedical Applications of Silver Nanoparticles.	Dayma P, Choudhary N, Ali D, Alarifi S, Dudhagara P, Luhana K, Yadav VK, Patel A, Patel R.	Pharmaceuticals (Basel)	10.3390/ph17060743	2024
	Aerobic dichlorvos degradation by Pseudomonas stutzeri smk: complete pathway and implications for toxicity in Mus musculus.	Parte SG, Mohekar AD, Kharat AS.	Iran J Microbiol	10.18502/ijm.v12i2.2619	2020
Pathogenicity	Chemomicin A, a new angucyclinone antibiotic produced by Nocardia mediterranei subsp. kanglensis 1747-64.	Sun CH, Wang Y, Wang Z, Zhou JQ, Jin WZ, You XF, Gao H, Zhao LX, Si SY, Li X.	J Antibiot (Tokyo)	10.1038/ja.2007.25	2007
Pathogenicity	Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells.	Li Y, Han N, Gao N, Xu R, Sun C, Li D, He Q.	Oncol Rep	10.3892/or_00000658	2010
Metabolism	Preliminary report on the biological effects of space flight on the producing strain of a new immunosuppressant, Kanglemycin C.	Zhou J, Sun C, Wang N, Gao R, Bai S, Zheng H, You X, Li R.	J Ind Microbiol Biotechnol	10.1007/s10295-006-0118-z	2006
	Effects of intraocular rifampicin on retinal ganglion cell structure: a stereological and histopathological study.	Cakici O, Aksak S, Unal D, Sipal S, Keles S, Dumlu T, Karamese M.	Int J Ophthalmol	10.3980/j.issn.2222-3959.2013.05.08	2013
	The protective effect of topical rifamycin treatment against sternal wound infection in diabetic patients undergoing on-pump coronary artery bypass graft surgery.	Aygun F, Kuzgun A, Ulucan S, Keser A, Akpek M, Kaya M.	Cardiovasc J Afr	10.5830/cvja-2014-008	2014
Metabolism	Quantitative analysis of mycelium morphological characteristics and rifamycin B production using Nocardia mediterranei.	Lee KJ, Rho YT.	J Biotechnol	10.1016/0168-1656(94)90155-4	1994
	Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.	Almuhayawi MS, Mohamed MSM, Abdel-Mawgoud M, Selim S, Al Jaouni SK, AbdElgawad H.	Biology (Basel)	10.3390/biology10030235	2021
Pathogenicity	Tuberculosis Drug Development: History and Evolution of the Mechanism-Based Paradigm.	Chakraborty S, Rhee KY.	Cold Spring Harb Perspect Med	10.1101/cshperspect.a021147	2015
Enzymology	Purification and properties of DAHP synthase from Nocardia mediterranei.	Xia TH, Chiao JS.	Biochim Biophys Acta	10.1016/0304-4165(89)90019-6	1989
	Biotransformations of rifamycins: process possibilities.	Banerjee UC, Saxena B, Chisti Y.	Biotechnol Adv	10.1016/0734-9750(92)91454-m	1992
Metabolism	Regulation of the biosynthetic pathway of aromatic amino acids in Nocardia mediterranei.	Xia TH, Chiao JS.	Biochim Biophys Acta	10.1016/0304-4165(89)90020-2	1989
Metabolism	Rifampin induces hydroxyl radical formation in Mycobacterium tuberculosis.	Piccaro G, Pietraforte D, Giannoni F, Mustazzolu A, Fattorini L.	Antimicrob Agents Chemother	10.1128/aac.03169-14	2014
Metabolism	New rifamycins produced by a recombinant strain of Nocardia mediterranei.	Schupp T, Traxler P, Auden JA.	J Antibiot (Tokyo)	10.7164/antibiotics.34.965	1981
	The chromosomal integration site of the Streptomyces element pSAM2 overlaps a putative tRNA gene conserved among actinomycetes.	Mazodier P, Thompson C, Boccard F.	Mol Gen Genet	10.1007/bf00633850	1990
Enzymology	3-Hydroxyrifamycin S and further novel ansamycins from a recombinant strain R-21 of Nocardia mediterranei.	Traxler P, Schupp T, Fuhrer H, Richter WJ.	J Antibiot (Tokyo)	10.7164/antibiotics.34.971	1981
Metabolism	A genetic approach to the biosynthesis of the rifamycin-chromophore in Nocardia mediterranei. IV. Identification of 3-amino-5-hydroxybenzoic acid as a direct precursor of the seven-carbon amino starter-unit.	Ghisalba O, Nuesch J.	J Antibiot (Tokyo)	10.7164/antibiotics.34.64	1981
Metabolism	A genetic approach to the biosynthesis of the rifamycin-chromophore in Nocardia mediterranei. III. Isolation and identification of an early aromatic ansamycin-precursor containing the seven-carbon amino starter-unit and three initial acetate/propionate-units of the ansa chain.	Ghisalba O, Fuhrer H, Richter WJ, Moss S.	J Antibiot (Tokyo)	10.7164/antibiotics.34.58	1981
Metabolism	A genetic approach to the biosynthesis of the rifamycin-chromophore in Nocardia mediterranei. I. Isolation and characterization of a pentose-excreting auxotrophic mutant of Nocardia mediterranei with drastically reduced rifamycin production.	Ghisalba O, Nuesch J.	J Antibiot (Tokyo)	10.7164/antibiotics.31.202	1978
Metabolism	Resistance in inhibitors of RNA polymerase in actinomycetes which produce them.	Blanco MG, Hardisson C, Salas JA.	J Gen Microbiol	10.1099/00221287-130-11-2883	1984
Metabolism	A genetic approach to the biosynthesis of the rifamycin-chromophore in Nocardia mediterranei. II. Isolation and characterization of a shikimate excreting auxotrophic mutant of Nocardia mediterranei with normal rifamycin-production.	Ghisalba O, Nuesch J.	J Antibiot (Tokyo)	10.7164/antibiotics.31.215	1978
	History of the development of rifampin.	Sensi P.	Rev Infect Dis	10.1093/clinids/5.supplement_3.s402	1983
Enzymology	Early intermediates in the biosynthesis of ansamycins. I. Isolation and identification of protorifamycin I.	Ghisalba O, Traxler P, Nuesch J.	J Antibiot (Tokyo)	10.7164/antibiotics.31.1124	1978
Pathogenicity	Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.	Mosaei H, Molodtsov V, Kepplinger B, Harbottle J, Moon CW, Jeeves RE, Ceccaroni L, Shin Y, Morton-Laing S, Marrs ECL, Wills C, Clegg W, Yuzenkova Y, Perry JD, Bacon J, Errington J, Allenby NEE, Hall MJ, Murakami KS, Zenkin N.	Mol Cell	10.1016/j.molcel.2018.08.028	2018
Enzymology	Purification and properties of glutamate synthase from Nocardia mediterranei.	Mei BG, Jiao RS.	J Bacteriol	10.1128/jb.170.4.1940-1944.1988	1988
Genetics	Complete genome sequence analysis of Nocardia brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis.	Vera-Cabrera L, Ortiz-Lopez R, Elizondo-Gonzalez R, Ocampo-Candiani J.	PLoS One	10.1371/journal.pone.0065425	2013
	Construction of a hybrid plasmid capable of replication in Amycolatopsis mediterranei.	Lal R, Lal S, Grund E, Eichenlaub R.	Appl Environ Microbiol	10.1128/aem.57.3.665-671.1991	1991
Metabolism	Ansamycin biogenesis: studies on a novel rifamycin isolated from a mutant strain of Nocardia mediterranei.	White RJ, Martinelli E, Lancini G.	Proc Natl Acad Sci U S A	10.1073/pnas.71.8.3260	1974
	Tuberculosis chemotherapy: current drug delivery approaches.	du Toit LC, Pillay V, Danckwerts MP.	Respir Res	10.1186/1465-9921-7-118	2006
Metabolism	Characterization of a bifunctional archaeal acyl coenzyme A carboxylase.	Chuakrut S, Arai H, Ishii M, Igarashi Y.	J Bacteriol	10.1128/jb.185.3.938-947.2003	2003
Biotechnology	Improved Rifamycin B Production by Nocardia mediterranei MTCC 14 under Solid-State Fermentation through Process Optimization.	Vastrad BM, Neelagund SE, Iiger SR, Godbole AM, Kulkarni V	Biochem Res Int	10.1155/2014/621309	2014
Enzymology	Transformation system for Amycolatopsis (Nocardia) mediterranei: direct transformation of mycelium with plasmid DNA.	Madon J, Hutter R	J Bacteriol	10.1128/jb.173.20.6325-6331.1991	1991
Genetics	Amplification on the Amycolatopsis (Nocardia) mediterranei plasmid pMEA100: sequence similarities to actinomycete att sites.	Zhu B, Madon J, Hausler A, Hutter R	Plasmid	10.1016/0147-619x(90)90015-5	1990
Enzymology	Site-specific integration and excision of pMEA100 in Nocardia mediterranei.	Madon J, Moretti P, Hutter R	Mol Gen Genet	10.1007/BF00329651	1987
Phylogeny	Isolation and characterization of an extrachromosomal element from Nocardia mediterranei.	Moretti P, Hintermann G, Hutter R	Plasmid	10.1016/0147-619x(85)90072-1	1985
Metabolism	Genetic recombination in Nocardia mediterranei.	Schupp T, Hutter R, Hopwood DA	J Bacteriol	10.1128/jb.121.1.128-136.1975	1975
Enzymology	Development of an improved cloning vector and transformation system in Amycolatopsis mediterranei (Nocardia mediterranei).	Lal R, Khanna R, Dhingra N, Khanna M, Lal S	J Antibiot (Tokyo)	10.7164/antibiotics.51.161	1998

References

#10944	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 43304
#19565	Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20216	Curators of the JMRC: Jena Microbial Resource Collection (JMRC):
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#39652	; Curators of the CIP;
#55691	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 43144
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120876	Collection of Institut Pasteur ; Curators of the CIP; CIP 107074
#124042	Johannes Wittmann, Clara Rolland, Lorenz Reimer, Joaquim Sardà: PhageDive .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Amycolatopsis mediterranei (DSM 43304, ATCC 13685, CBS 121.63)

Name and taxonomic classification

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API biotype100

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