Acutalibacter muris (DSM 26090, KCTC 15540, KB18)

Name: Acutalibacter muris (DSM 26090, KCTC 15540, KB18)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 131515

Type strain

Strain Designation KB18

Culture col. no. DSM 26090 KCTC 15540 KB18

NCBI tax ID(s) 1796620

Special Collections DSMZ KCTC Mouse DZIF

History DSMZ <- B. Stecher, Max von Pettenkofer-Inst., Munich; KB18 KCTC <- Barbel Fosel, DSM <- B Stecher, Max von Pettenkofer-Inst., Munich, KB18

Links

Acutalibacter muris KB18 is an anaerobe, rod-shaped bacterium that was isolated from feces, SPF TCR^MOG92-106/I-As transgenic SJL/J mouse.

rod-shaped anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 400889

KCTC 15540,DSM 26090

@ref 20215

Last LPSN update 2026-05-29 08:37:38

Domain Bacteria

Phylum Bacillota

Class Clostridia

Order Eubacteriales

Family Oscillospiraceae

Genus Acutalibacter

Species Acutalibacter muris

Full scientific name Acutalibacter muris Lagkouvardos et al. 2016

Morphology

Cell morphology

@ref	Cell shape	Gram stain
68367	rod-shaped		from API 20A
67771		positive

Colony morphology

22742

Incubation period3-7 days

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
22742	BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58)		Medium recipe at MediaDive	Name: BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58) Composition: Glucose 10.0 g/l Casein peptone 10.0 g/l Bacto Soytone 5.0 g/l Meat extract 5.0 g/l Yeast extract 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l MnSO4 x H2O 0.05 g/l KH2PO4 0.04 g/l K2HPO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Tween 80 Resazurin Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
22742	positive	growth	37
67771	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
22742	anaerobe
67771	anaerobe
125439	anaerobe	99.58

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
68367	17057 ChEBI	cellobiose	-	builds acid from	from API 20A
68367	17634 ChEBI	D-glucose	-	builds acid from	from API 20A
68367	16899 ChEBI	D-mannitol	-	builds acid from	from API 20A
68380	16024 ChEBI	D-mannose	-	fermentation	from API rID32A
68367	16024 ChEBI	D-mannose	-	builds acid from	from API 20A
68367	65327 ChEBI	D-xylose	-	builds acid from	from API 20A
68367	4853 ChEBI	esculin	+	hydrolysis	from API 20A
68367	17754 ChEBI	glycerol	-	builds acid from	from API 20A
68367	30849 ChEBI	L-arabinose	-	builds acid from	from API 20A
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68367	62345 ChEBI	L-rhamnose	-	builds acid from	from API 20A
68367	17716 ChEBI	lactose	-	builds acid from	from API 20A
68367	17306 ChEBI	maltose	-	builds acid from	from API 20A
68367	6731 ChEBI	melezitose	-	builds acid from	from API 20A
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
68380	16634 ChEBI	raffinose	-	fermentation	from API rID32A
68367	16634 ChEBI	raffinose	-	builds acid from	from API 20A
68367	17814 ChEBI	salicin	-	builds acid from	from API 20A
68367	30911 ChEBI	sorbitol	-	builds acid from	from API 20A
68367	17992 ChEBI	sucrose	-	builds acid from	from API 20A
68367	27082 ChEBI	trehalose	-	builds acid from	from API 20A
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68367	27897 ChEBI	tryptophan	-	energy source	from API 20A
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A
68367	16199 ChEBI	urea	-	hydrolysis	from API 20A

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68380	35581 ChEBI	indole		from API rID32A
68367	35581 ChEBI	indole		from API 20A

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68380	35581 ChEBI	indole	-	from API rID32A
68367	35581 ChEBI	indole	-	from API 20A

Enzymes

@ref	Value	Activity	Ec
68380	alanine arylamidase	-	3.4.11.2	from API rID32A
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	+	3.2.1.55	from API rID32A
68380	alpha-fucosidase	+	3.2.1.51	from API rID32A
68380	alpha-galactosidase	+	3.2.1.22	from API rID32A
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68380	beta-galactosidase	+	3.2.1.23	from API rID32A
68380	beta-glucosidase	+	3.2.1.21	from API rID32A
68367	beta-glucosidase	+	3.2.1.21	from API 20A
68380	beta-glucuronidase	+	3.2.1.31	from API rID32A
68367	catalase	-	1.11.1.6	from API 20A
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	L-arginine arylamidase	-		from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68380	serine arylamidase	-		from API rID32A
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	urease	-	3.5.1.5	from API rID32A
68367	urease	-	3.5.1.5	from API 20A

API 20A

@ref	IND	URE	GLU	MAN	LAC	SAC	MAL	SAL	XYL	ARA	GEL	ESC	GLY	CEL	MNE	MLZ	RAF	SOR	RHA	TRE	CAT	Spores presentSPOR	GramGRAM	Morphology coccus="+" rod="-"COCC
22742	-	-	-	-	-	-	-	-	-	-	+/-	+	-	-	-	-	-	-	-	-	-	not determinedn.d.	not determinedn.d.	-
22742	-	-	-	-	-	-	-	-	-	-	+/-	+	-	-	-	-	-	-	-	-	-	not determinedn.d.	not determinedn.d.	-

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
22742	-	-	+	+	+/-	-	+	+	+	-	-	-	-	+	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-
22742	-	-	+	+	+	+/-	+	+	+	-	-	-	-	+	-	-	-	-	-	-	-	+/-	-	+/-	-	+/-	+/-	-	-
22742	-	-	+	+	+	-	+	+	+	-	-	-	-	+	-	-	-	-	-	-	-	+/-	+	-	-	-	-	-	-
22742	-	-	+	+	+	+/-	+	+	+	-	-	-	-	+	-	-	-	-	-	-	-	+/-	-	+/-	-	+/-	+/-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Mammals	#Muridae (Mouse/Rat)
#Host Body Product	#Gastrointestinal tract	#Feces (Stool)

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
22742	feces, SPF TCR^MOG92-106/I-As transgenic (RR) SJL/J mouse	Munich	Germany	DEU	Europe
67771	From feces, SPF TCRMOG92-106/I-As transgenic (RR) SJL/J mouse	Munich	Germany	DEU	Europe

Taxonmaps

69479

Global distribution of 16S sequence KR364749 (>99% sequence identity) for Acutalibacter muris subclade from Microbeatlas

Aquatic Samples	48
Soil Samples	66
Animal Samples	13538
Plant Samples	16
Total Samples	13668

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
22742	1	Risk group (German classification)

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM220147v1 assembly for Acutalibacter muris KB18	chromosome	GCA_002201475	1796620.3	2757320831	1796620	87.6
66792	ASM1669736v1 assembly for Acutalibacter muris KB18	chromosome	GCA_016697365	1796620.11	8063204789	1796620	86.74

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
22742	Acutalibacter muris strain KB18 16S ribosomal RNA gene, partial sequence	KR364749	1510		1796620

GC content

@ref	GC-content (mol%)	Method
22742	54.6	sequence analysis
67771	54.6

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM220147v1 assembly for Acutalibacter muris KB18
BV-BRC: 1796620.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	99.58	no
125439	gram_stain	BacteriaNetⓘ	negative	57.24	no
125439	spore_formation	BacteriaNetⓘ	yes	41.91	no
125439	motility	BacteriaNetⓘ	yes	43.88	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	In vitro and in vivo selection and cost of bacteriophage resistance on natural Escherichia coli.	Cardoso LL, Gaissmaier MS, von Strempel A, Keys T, Matchado MS, Salvado Silva M, Ring D, Slack E, Stecher B.	Microlife	10.1093/femsml/uqaf017	2025
	Microbiota-driven antitumour immunity mediated by dendritic cell migration.	Lin NY, Fukuoka S, Koyama S, Motooka D, Tourlousse DM, Shigeno Y, Matsumoto Y, Yamano H, Murotomi K, Tamaki H, Irie T, Sugiyama E, Kumagai S, Itahashi K, Tanegashima T, Fujimaki K, Ito S, Shindo M, Tsuji T, Wake H, Watanabe K, Maeda Y, Enokida T, Tahara M, Yamashita R, Fujisawa T, Nomura M, Kawazoe A, Goto K, Doi T, Shitara K, Mano H, Sekiguchi Y, Nakamura S, Benno Y, Nishikawa H.	Nature	10.1038/s41586-025-09249-8	2025
	Reproducible Colonization of Germ-Free Mice With the Oligo-Mouse-Microbiota in Different Animal Facilities.	Eberl C, Ring D, Munch PC, Beutler M, Basic M, Slack EC, Schwarzer M, Srutkova D, Lange A, Frick JS, Bleich A, Stecher B.	Front Microbiol	10.3389/fmicb.2019.02999	2019
	Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice.	von Strempel A, Weiss AS, Wittmann J, Salvado Silva M, Ring D, Wortmann E, Clavel T, Debarbieux L, Kleigrewe K, Stecher B.	PLoS Pathog	10.1371/journal.ppat.1011600	2023
	Nutritional and host environments determine community ecology and keystone species in a synthetic gut bacterial community.	Weiss AS, Niedermeier LS, von Strempel A, Burrichter AG, Ring D, Meng C, Kleigrewe K, Lincetto C, Hubner J, Stecher B.	Nat Commun	10.1038/s41467-023-40372-0	2023
Metabolism	The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice.	Streidl T, Karkossa I, Segura Munoz RR, Eberl C, Zaufel A, Plagge J, Schmaltz R, Schubert K, Basic M, Schneider KM, Afify M, Trautwein C, Tolba R, Stecher B, Doden HL, Ridlon JM, Ecker J, Moustafa T, von Bergen M, Ramer-Tait AE, Clavel T.	Gut Microbes	10.1080/19490976.2020.1854008	2021
Metabolism	In vitro and in vivo characterization of Clostridium scindens bile acid transformations.	Marion S, Studer N, Desharnais L, Menin L, Escrig S, Meibom A, Hapfelmeier S, Bernier-Latmani R.	Gut Microbes	10.1080/19490976.2018.1549420	2019
Metabolism	Functional Intestinal Bile Acid 7alpha-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model.	Studer N, Desharnais L, Beutler M, Brugiroux S, Terrazos MA, Menin L, Schurch CM, McCoy KD, Kuehne SA, Minton NP, Stecher B, Bernier-Latmani R, Hapfelmeier S.	Front Cell Infect Microbiol	10.3389/fcimb.2016.00191	2016

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#22742	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 26090
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67771	Korean Collection for Type Cultures (KCTC) ; Curators of the KCTC;
#68367	Automatically annotated from API 20A .
#68380	Automatically annotated from API rID32A .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Acutalibacter muris (DSM 26090, KCTC 15540, KB18)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

API 20A

API rID32A

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_002201475

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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