Name: Akkermansia muciniphila YL44
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 131145

Type strain:

Species: Akkermansia muciniphila

Strain Designation: YL44

Culture col. no.: DSM 26127

Strain history: <- B. Stecher, Max von Pettenkofer-Inst., Munich; YL44

NCBI tax ID(s): 239935 (species)

SI-ID 402607

DSM 26127

Other strains from Akkermansia muciniphila

A. muciniphila Muc, MucT, DSM 22959, ATCC BAA-835, ... (type strain)
A. muciniphila JCM 30893

Section

Akkermansia muciniphila YL44 is an anaerobe, mesophilic bacterium that was isolated from C57BL/6J wildtype mouse.

anaerobe
mesophilic
16S sequence
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Verrucomicrobiota*
	Class	*Verrucomicrobiia*
	Order	*Verrucomicrobiales*
	Family	*Akkermansiaceae*
	Genus	*Akkermansia*
	Species	**Akkermansia muciniphila**
	Full Scientific Name (LPSN)	Akkermansia muciniphila Derrien et al. 2004

Information on morphological and physiological properties Morphology

[Ref.: #22437]

Incubation period

2-3 days

Information on culture and growth conditions Culture and growth conditions

[Ref.: #22437]

Culture medium

COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)

[Ref.: #22437]

Culture medium growth

[Ref.: #22437]

Culture medium link

Medium recipe at MediaDive

[Ref.: #22437]

Culture medium composition

expand / minimize

[Ref.: #22437]

Culture medium

CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110)

[Ref.: #22437]

Culture medium growth

[Ref.: #22437]

Culture medium link

Medium recipe at MediaDive

[Ref.: #22437]

Culture medium composition

expand / minimize

	Temperatures	Kind of temperature		Temperature
[Ref.: #22437]			growth	37 °C

[Ref.: #22437]

Temperature range

mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #22437]

Oxygen tolerance

anaerobe

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68380]	arginine ChEBI	-	hydrolysis	* from API rID32A
[Ref.: #68367]	cellobiose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	D-glucose ChEBI	+	builds acid from	* from API 20A
[Ref.: #68367]	D-mannitol ChEBI	-	builds acid from	* from API 20A
[Ref.: #68380]	D-mannose ChEBI	-	fermentation	* from API rID32A
[Ref.: #68367]	D-xylose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	esculin ChEBI	-	hydrolysis	* from API 20A
[Ref.: #68367]	gelatin ChEBI	-	hydrolysis	* from API 20A
[Ref.: #68367]	glycerol ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	L-arabinose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68380]	L-glutamate ChEBI	-	degradation	* from API rID32A
[Ref.: #68367]	L-rhamnose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	maltose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	melezitose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68380]	nitrate ChEBI	-	reduction	* from API rID32A
[Ref.: #68367]	raffinose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68380]	raffinose ChEBI	-	fermentation	* from API rID32A
[Ref.: #68367]	salicin ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	sorbitol ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	sucrose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	trehalose ChEBI	-	builds acid from	* from API 20A
[Ref.: #68367]	tryptophan ChEBI	-	energy source	* from API 20A, API rID32A
[Ref.: #68367]	urea ChEBI	-	hydrolysis	* from API 20A, API rID32A
	Only first 10 entries are displayed. Click here to see all.

	Metabolite production	Metabolite	Production
[Ref.: #68367]		indole ChEBI	no	* from API 20A, API rID32A

	Physiological tests	Metabolite	Indole test
[Ref.: #68380]		indole ChEBI	-	* from API rID32A, API 20A

	Enzyme	Enzyme activity	EC number
[Ref.: #68380]	alanine arylamidase	-	3.4.11.2	* from API rID32A
[Ref.: #68380]	alkaline phosphatase	-	3.1.3.1	* from API rID32A
[Ref.: #68380]	alpha-arabinosidase	-	3.2.1.55	* from API rID32A
[Ref.: #68380]	alpha-fucosidase	-	3.2.1.51	* from API rID32A
[Ref.: #68380]	alpha-galactosidase	-	3.2.1.22	* from API rID32A
[Ref.: #68380]	alpha-glucosidase	-	3.2.1.20	* from API rID32A
[Ref.: #68380]	arginine dihydrolase	-	3.5.3.6	* from API rID32A
[Ref.: #68380]	beta-galactosidase	+	3.2.1.23	* from API rID32A
[Ref.: #68380]	beta-Galactosidase 6-phosphate	-		* from API rID32A
[Ref.: #68380]	beta-glucosidase	-	3.2.1.21	* from API rID32A, API 20A
[Ref.: #68380]	beta-glucuronidase	-	3.2.1.31	* from API rID32A
[Ref.: #68367]	gelatinase	-		* from API 20A
[Ref.: #68380]	glutamate decarboxylase	-	4.1.1.15	* from API rID32A
[Ref.: #68380]	glutamyl-glutamate arylamidase	-		* from API rID32A
[Ref.: #68380]	glycin arylamidase	-		* from API rID32A
[Ref.: #68380]	histidine arylamidase	-		* from API rID32A
[Ref.: #68380]	leucine arylamidase	-	3.4.11.1	* from API rID32A
[Ref.: #68380]	leucyl glycin arylamidase	-	3.4.11.1	* from API rID32A
[Ref.: #68380]	N-acetyl-beta-glucosaminidase	+	3.2.1.52	* from API rID32A
[Ref.: #68380]	phenylalanine arylamidase	-		* from API rID32A
[Ref.: #68380]	proline-arylamidase	-	3.4.11.5	* from API rID32A
[Ref.: #68380]	pyrrolidonyl arylamidase	-	3.4.19.3	* from API rID32A
[Ref.: #68380]	serine arylamidase	-		* from API rID32A
[Ref.: #68380]	tryptophan deaminase	-	4.1.99.1	* from API rID32A
[Ref.: #68380]	tyrosine arylamidase	-		* from API rID32A
[Ref.: #68380]	urease	-	3.5.1.5	* from API rID32A, API 20A
	Only first 10 entries are displayed. Click here to see all.

API® 20A:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Indole productionIND	Urease/urea hydrolysisURE	Acid from D-glucoseGLU	Acid from D-mannitolMAN	Acid from lactoseLAC	Acid from sucroseSAC	Acid from maltoseMAL	Acid from salicinSAL	Acid from D-xyloseXYL	Acid from L-arabinoseARA	Gelatinase/gelatin hydrolysisGEL	Esculin hydrolysis/beta-glucosidaseESC	Acid from glycerolGLY	Acid from cellobioseCEL	Acid from D-mannoseMNE	Acid from melezitoseMLZ	Acid from raffinoseRAF	Acid from sorbitolSOR	Acid from L-rhamnoseRHA	Acid from trehaloseTRE	CatalaseCAT	Spores presentSPOR	GramGRAM	Morphology coccus="+" rod="-"COCC
[Ref.: #22437]	2178	-	-	+	-	+/-	-	-	-	-	-	-	-	-	-	+/-	-	-	-	-	-	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.
[Ref.: #22437]	2155	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.

API® rID32A:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Urease/urea hydrolysisURE	Arginine dihydrolaseADH (Arg)	alpha-Galactosidasealpha GAL	beta-Galactosidasebeta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha-Glucosidasealpha GLU	beta-Glucosidasebeta GLU	alpha-Arabinosidasealpha ARA	beta-Glucuronidasebeta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	Fermentation of D-mannoseMNE	Fermentation of raffinoseRAF	Glutamate decarboxylaseGDC	alpha-Fucosidasealpha FUC	Reduction of nitrateNIT	Indole productionIND	Alkaline phosphatasePAL	L-arginine arylamidaseArgA	Proline arylamidaseProA	Leucyl glycin arylamidaseLGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	Pyrrolidonyl arylamidasePyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
[Ref.: #22437]	13295	-	-	-	+	-	-	-	-	-	+	-	-	-	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-
[Ref.: #22437]	13070	-	-	-	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
[Ref.: #22437]	12924	-	-	-	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #22437]	Sample type/isolated from	C57BL/6J wildtype mouse
[Ref.: #22437]	Geographic location (country and/or sea, region)	Zurich
[Ref.: #22437]	Country	Switzerland
[Ref.: #22437]	Country ISO 3 Code	CHE
[Ref.: #22437]	Continent	Europe
* marker position based on {}

Isolation sources categories

#Host

#Mammals

#Muridae (Mouse/Rat)

What are isolation sources categories?

[Ref.: #69479]

Global distribution of 16S sequence KR364731 (>99% sequence identity) for Akkermansia muciniphila subclade from Microbeatlas

Aquatic Samples	4383
Soil Samples	1656
Animal Samples	128875
Plant Samples	623
Total Samples	135537

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #22437]

Biosafety level

Risk group (German classification)
According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #22437]	Akkermansia muciniphila strain YL44 16S ribosomal RNA gene, partial sequence	KR364731	1500	ENA	239935 tax ID

Genome sequence information:

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Akkermansia muciniphila YL44	GCA_001688765	complete	GenBank	239935 tax ID	*
[Ref.: #66792]	Akkermansia muciniphila YL44	GCA_002201495	chromosome	GenBank	239935 tax ID	*
[Ref.: #66792]	Akkermansia muciniphila YL44	GCA_016697425	chromosome	GenBank	239935 tax ID	*
[Ref.: #66792]	Akkermansia muciniphila YL44	2721755767	complete	JGI IMG/M	239935 tax ID	*
[Ref.: #66792]	Akkermansia muciniphila YL44	2833038095	complete	JGI IMG/M	239935 tax ID	*

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Akkermansia muciniphila YL44 NCBI: GCA_001688765.1
[Ref.: #69480]	flagellated	no	96.741	no
[Ref.: #69480]	gram-positive	no	98.462	no
[Ref.: #69480]	anaerobic	yes	97.07	no
[Ref.: #69480]	halophile	no	92.146	no
[Ref.: #69480]	spore-forming	no	98.294	no
[Ref.: #69480]	glucose-util	yes	74.916	no
[Ref.: #69480]	aerobic	no	95.24	yes
[Ref.: #69480]	thermophile	no	98.275	no
[Ref.: #69480]	motile	no	89.239	no
[Ref.: #69480]	glucose-ferment	no	59.16	no
[Ref.: #69480]	flagellated	no	96.741	no
[Ref.: #69480]	gram-positive	no	98.462	no
[Ref.: #69480]	anaerobic	yes	97.07	no
[Ref.: #69480]	halophile	no	92.146	no
[Ref.: #69480]	spore-forming	no	98.294	no
[Ref.: #69480]	glucose-util	yes	74.916	no
[Ref.: #69480]	aerobic	no	95.24	yes
[Ref.: #69480]	thermophile	no	98.275	no
[Ref.: #69480]	motile	no	89.239	no
[Ref.: #69480]	glucose-ferment	no	59.16	no

Availability in culture collections External links

[Ref.: #22437]

Culture collection no.

DSM 26127

[Ref.: #89598]

SI-ID 402607

References

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#22437

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 26127

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#68367

Automatically annotated from API 20A .

#68380

Automatically annotated from API rID32A .

#69479

João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#89598

Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID402607.1 )

* These data were automatically processed and therefore are not curated

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