Akkermansia muciniphila YL44 is an anaerobe, mesophilic prokaryote that was isolated from C57BL/6J wildtype mouse.
anaerobe mesophilic genome sequence 16S sequence| @ref 20215 |
Last LPSN update
2025-12-16 10:01:10 |
| Domain Pseudomonadati |
| Phylum Verrucomicrobiota |
| Class Verrucomicrobiia |
| Order Verrucomicrobiales |
| Family Akkermansiaceae |
| Genus Akkermansia |
| Species Akkermansia muciniphila |
| Full scientific name Akkermansia muciniphila Derrien et al. 2004 |
| BacDive ID | Other strains from Akkermansia muciniphila (2) | Type strain |
|---|---|---|
| 17849 | A. muciniphila Muc, MucT, DSM 22959, ATCC BAA-835, CIP 107961, ... (type strain) | |
| 163900 | A. muciniphila JCM 30893 |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 22437 | COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) | Medium recipe at MediaDive  | Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base | ||
| 22437 | CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110) | Medium recipe at MediaDive | Name: CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110) Composition: Ground beef 500.0 g/l Casitone 30.0 g/l Agar 15.0 g/l K2HPO4 5.0 g/l Yeast extract 5.0 g/l D-Glucose 4.0 g/l Starch 1.0 g/l Maltose 1.0 g/l Cellobiose 1.0 g/l L-Cysteine HCl 0.5 g/l Ethanol 0.19 g/l Vitamin K3 0.05 g/l Hemin 0.005 g/l Sodium resazurin 0.0005 g/l Vitamin K1 NaOH Distilled water |
| @ref | Growth | Type | Temperature (°C) | Range | |
|---|---|---|---|---|---|
| 22437 | positive | growth | 37 | mesophilic |
| @ref | Spore formation | Confidence | |
|---|---|---|---|
| 125439 | 92.2 |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68380 | 29016 ChEBI | arginine | - | hydrolysis | from API rID32A |
| 68367 | 17057 ChEBI | cellobiose | - | builds acid from | from API 20A |
| 68367 | 17634 ChEBI | D-glucose | + | builds acid from | from API 20A |
| 68367 | 16899 ChEBI | D-mannitol | - | builds acid from | from API 20A |
| 68380 | 16024 ChEBI | D-mannose | - | fermentation | from API rID32A |
| 68367 | 65327 ChEBI | D-xylose | - | builds acid from | from API 20A |
| 68367 | 4853 ChEBI | esculin | - | hydrolysis | from API 20A |
| 68367 | 5291 ChEBI | gelatin | - | hydrolysis | from API 20A |
| 68367 | 17754 ChEBI | glycerol | - | builds acid from | from API 20A |
| 68367 | 30849 ChEBI | L-arabinose | - | builds acid from | from API 20A |
| 68380 | 29985 ChEBI | L-glutamate | - | degradation | from API rID32A |
| 68367 | 62345 ChEBI | L-rhamnose | - | builds acid from | from API 20A |
| 68367 | 17306 ChEBI | maltose | - | builds acid from | from API 20A |
| 68367 | 6731 ChEBI | melezitose | - | builds acid from | from API 20A |
| 68380 | 17632 ChEBI | nitrate | - | reduction | from API rID32A |
| 68380 | 16634 ChEBI | raffinose | - | fermentation | from API rID32A |
| 68367 | 16634 ChEBI | raffinose | - | builds acid from | from API 20A |
| 68367 | 17814 ChEBI | salicin | - | builds acid from | from API 20A |
| 68367 | 30911 ChEBI | sorbitol | - | builds acid from | from API 20A |
| 68367 | 17992 ChEBI | sucrose | - | builds acid from | from API 20A |
| 68367 | 27082 ChEBI | trehalose | - | builds acid from | from API 20A |
| 68380 | 27897 ChEBI | tryptophan | - | energy source | from API rID32A |
| 68367 | 27897 ChEBI | tryptophan | - | energy source | from API 20A |
| 68380 | 16199 ChEBI | urea | - | hydrolysis | from API rID32A |
| 68367 | 16199 ChEBI | urea | - | hydrolysis | from API 20A |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68380 | alanine arylamidase | - | 3.4.11.2 | from API rID32A |
| 68380 | alkaline phosphatase | - | 3.1.3.1 | from API rID32A |
| 68380 | alpha-arabinosidase | - | 3.2.1.55 | from API rID32A |
| 68380 | alpha-fucosidase | - | 3.2.1.51 | from API rID32A |
| 68380 | alpha-galactosidase | - | 3.2.1.22 | from API rID32A |
| 68380 | alpha-glucosidase | - | 3.2.1.20 | from API rID32A |
| 68380 | arginine dihydrolase | - | 3.5.3.6 | from API rID32A |
| 68380 | beta-galactosidase | + | 3.2.1.23 | from API rID32A |
| 68380 | beta-Galactosidase 6-phosphate | - | from API rID32A | |
| 68380 | beta-glucosidase | - | 3.2.1.21 | from API rID32A |
| 68367 | beta-glucosidase | - | 3.2.1.21 | from API 20A |
| 68380 | beta-glucuronidase | - | 3.2.1.31 | from API rID32A |
| 68367 | gelatinase | - | from API 20A | |
| 68380 | glutamate decarboxylase | - | 4.1.1.15 | from API rID32A |
| 68380 | glutamyl-glutamate arylamidase | - | from API rID32A | |
| 68380 | glycin arylamidase | - | from API rID32A | |
| 68380 | histidine arylamidase | - | from API rID32A | |
| 68380 | leucine arylamidase | - | 3.4.11.1 | from API rID32A |
| 68380 | leucyl glycin arylamidase | - | 3.4.11.1 | from API rID32A |
| 68380 | N-acetyl-beta-glucosaminidase | + | 3.2.1.52 | from API rID32A |
| 68380 | phenylalanine arylamidase | - | from API rID32A | |
| 68380 | proline-arylamidase | - | 3.4.11.5 | from API rID32A |
| 68380 | pyrrolidonyl arylamidase | - | 3.4.19.3 | from API rID32A |
| 68380 | serine arylamidase | - | from API rID32A | |
| 68380 | tryptophan deaminase | - | 4.1.99.1 | from API rID32A |
| 68380 | tyrosine arylamidase | - | from API rID32A | |
| 68380 | urease | - | 3.5.1.5 | from API rID32A |
| 68367 | urease | - | 3.5.1.5 | from API 20A |
| @ref | IND | URE | GLU | MAN | LAC | SAC | MAL | SAL | XYL | ARA | GEL | ESC | GLY | CEL | MNE | MLZ | RAF | SOR | RHA | TRE | CAT | Spores presentSPOR | GramGRAM | Morphology coccus="+" rod="-"COCC | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 22437 | - | - | + | - | +/- | - | - | - | - | - | - | - | - | - | +/- | - | - | - | - | - | not determinedn.d. | not determinedn.d. | not determinedn.d. | not determinedn.d. | |
| 22437 | - | - | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | not determinedn.d. | not determinedn.d. | not determinedn.d. | not determinedn.d. |
| @ref | URE | ADH (Arg) | alpha GAL | beta GAL | beta-Galactosidase 6-phosphatebeta GP | alpha GLU | beta GLU | alpha ARA | beta GUR | beta-N-Acetyl-beta-glucosaminidasebeta NAG | MNE | RAF | GDC | alpha FUC | Reduction of nitrateNIT | IND | PAL | L-arginine arylamidaseArgA | ProA | LGA | Phenylalanine arylamidasePheA | Leucine arylamidaseLeuA | PyrA | Tyrosine arylamidaseTyrA | Alanine arylamidaseAlaA | Glycin arylamidaseGlyA | Histidine arylamidaseHisA | Glutamyl-glutamate arylamidaseGGA | Serine arylamidaseSerA | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 22437 | - | - | - | + | - | - | - | - | - | + | - | - | - | - | - | - | - | +/- | - | - | - | - | - | - | - | - | - | - | - | |
| 22437 | - | - | - | + | - | - | - | - | - | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |
| 22437 | - | - | - | + | - | - | - | - | - | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| @ref | Sample type | Geographic location | Country | Country ISO 3 Code | Continent | |
|---|---|---|---|---|---|---|
| 22437 | C57BL/6J wildtype mouse | Zurich | Switzerland | CHE | Europe |
Global distribution of 16S sequence KR364731 (>99% sequence identity) for Akkermansia muciniphila subclade from Microbeatlas 
 Aquatic Samples |
4383 |
 Soil Samples |
1656 |
 Animal Samples |
128875 |
 Plant Samples |
623 |
| Total Samples | 135537 |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 66792 | ASM168876v2 assembly for Akkermansia muciniphila YL44 | complete | GCA_001688765   | 2721755767  | 239935 | 99.18 | | |
| 66792 | ASM220149v1 assembly for Akkermansia muciniphila YL44 | chromosome | GCA_002201495 | 239935.44  | 2833038095 | 239935 | 89.23 | |
| 66792 | ASM1669742v1 assembly for Akkermansia muciniphila YL44 | chromosome | GCA_016697425 | 239935.2325 | 8003494075 | 239935 | 88.98 | |
| @ref | Description | Accession | Length | Database | NCBI tax ID | |
|---|---|---|---|---|---|---|
| 22437 | Akkermansia muciniphila strain YL44 16S ribosomal RNA gene, partial sequence | KR364731 | 1500 |  | 239935 |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| The human intestinal bacterium Eggerthella lenta influences gut metabolomes in gnotobiotic mice | Viehof A, Haange S, Streidl T, Schubert K, Engelmann B, Haller D, Rolle-Kampczyk U, von Bergen M, Clavel T. | Microbiome Res Rep | 2024 | | ||
| Complete Genome Sequences of 12 Species of Stable Defined Moderately Diverse Mouse Microbiota 2. | Uchimura Y, Wyss M, Brugiroux S, Limenitakis JP, Stecher B, McCoy KD, Macpherson AJ. | Genome Announc | 10.1128/genomea.00951-16 | 2016 | | |
| Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice. | von Strempel A, Weiss AS, Wittmann J, Salvado Silva M, Ring D, Wortmann E, Clavel T, Debarbieux L, Kleigrewe K, Stecher B. | PLoS Pathog | 10.1371/journal.ppat.1011600 | 2023 | | |
| Metabolism | The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice. | Streidl T, Karkossa I, Segura Munoz RR, Eberl C, Zaufel A, Plagge J, Schmaltz R, Schubert K, Basic M, Schneider KM, Afify M, Trautwein C, Tolba R, Stecher B, Doden HL, Ridlon JM, Ecker J, Moustafa T, von Bergen M, Ramer-Tait AE, Clavel T. | Gut Microbes | 10.1080/19490976.2020.1854008 | 2021 | |
| Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation. | Lehmann FM, von Burg N, Ivanek R, Teufel C, Horvath E, Peter A, Turchinovich G, Staehli D, Eichlisberger T, Gomez de Aguero M, Coto-Llerena M, Prchal-Murphy M, Sexl V, Bentires-Alj M, Mueller C, Finke D. | Nat Commun | 10.1038/s41467-020-15612-2 | 2020 | | |
| Metabolism | In vitro and in vivo characterization of Clostridium scindens bile acid transformations. | Marion S, Studer N, Desharnais L, Menin L, Escrig S, Meibom A, Hapfelmeier S, Bernier-Latmani R. | Gut Microbes | 10.1080/19490976.2018.1549420 | 2019 | |
| Pathogenicity | Salt-responsive gut commensal modulates TH17 axis and disease. | Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mahler A, Balogh A, Marko L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Fratzer C, Krannich A, Gollasch M, Grohme DA, Corte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Muller DN. | Nature | 10.1038/nature24628 | 2017 | |
| Metabolism | Functional Intestinal Bile Acid 7alpha-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model. | Studer N, Desharnais L, Beutler M, Brugiroux S, Terrazos MA, Menin L, Schurch CM, McCoy KD, Kuehne SA, Minton NP, Stecher B, Bernier-Latmani R, Hapfelmeier S. | Front Cell Infect Microbiol | 10.3389/fcimb.2016.00191 | 2016 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive131145.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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