Acidithiobacillus ferrooxidans (DSM 14882, ATCC 23270, NCIMB 8455)

Name: Acidithiobacillus ferrooxidans (DSM 14882, ATCC 23270, NCIMB 8455)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 118

Type strain

Strain Designation TM

Culture col. no. DSM 14882 ATCC 23270 NCIMB 8455 TM

NCBI tax ID(s) 243159 920

Special Collections DSMZ

History DSMZ <- ATCC; ATCC 23270 <- NCIMB; NCIMB 8455 <- W. W. Leathen, Mellon Institute, Pittsburgh, USA; TM (Ferrobacillus ferrooxidans)

Links

Acidithiobacillus ferrooxidans TM is a bacterium that was isolated from acid, bituminous coal mine effluent.

genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 37980

ATCC 23270,NCIB 8455,NCIMB 8455,CIP104768,CECT 4532,CCRC 13822,DSM 14882,NCIM 5068

@ref 20215

Last LPSN update 2026-05-29 08:24:57

Domain Bacteria

Phylum Pseudomonadota

Class Acidithiobacillia

Order Acidithiobacillales

Family Acidithiobacillaceae

Genus Acidithiobacillus

Species Acidithiobacillus ferrooxidans

Full scientific name Acidithiobacillus ferrooxidans (Temple and Colmer 1951) Kelly and Wood 2000

Synonyms (1)

Thiobacillus ferrooxidans

BacDive ID	Other strains from **Acidithiobacillus ferrooxidans** (13)	Type strain
111	A. ferrooxidans DSM 583
112	A. ferrooxidans DSM 584
113	A. ferrooxidans DSM 585
114	A. ferrooxidans F221, DSM 1927
115	A. ferrooxidans N-Fe3, DSM 9464
116	A. ferrooxidans NFe-4, DSM 9465
117	A. ferrooxidans Tf18, DSM 11477
120	A. ferrooxidans SP5/1, DSM 24419, JCM 39165
130137	A. ferrooxidans R1, DSM 29444
162005	A. ferrooxidans JCM 17309
164860	A. ferrooxidans JCM 3863, ATCC 19859, BCRC 13033, NCIMB 9490
164861	A. ferrooxidans JCM 3865
165617	A. ferrooxidans JCM 7812

Morphology

Cell morphology

@ref	Gram stain	Confidence
125438	negative	96.548

Colony morphology

5597

Incubation period3-7 days

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
5597	LEPTOSPIRILLUM (HH) MEDIUM (DSMZ Medium 882)		Medium recipe at MediaDive	Name: LEPTOSPIRILLUM (HH) MEDIUM (DSMZ Medium 882) Composition: FeSO4 x 7 H2O 19.98 g/l CaCl2 x 2 H2O 0.146853 g/l (NH4)2SO4 0.131868 g/l MgCl2 x 6 H2O 0.0529471 g/l KH2PO4 0.0269731 g/l MnCl2 x 4 H2O 7.59241e-05 g/l ZnCl2 6.79321e-05 g/l CuCl2 x 2 H2O 6.69331e-05 g/l CoCl2 x 6 H2O 6.39361e-05 g/l H3BO3 3.0969e-05 g/l Na2MoO4 9.99001e-06 g/l H2SO4 Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
5597	positive	growth	25

Physiology and metabolism

Spore formation

@ref	Spore formation	Confidence
125439		97.144
125438		91.192

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	formaldehyde oxidation	100	3 of 3
66794	cardiolipin biosynthesis	100	7 of 7
66794	glycogen metabolism	100	5 of 5
66794	photosynthesis	100	14 of 14
66794	ppGpp biosynthesis	100	4 of 4
66794	coenzyme A metabolism	100	4 of 4
66794	methylglyoxal degradation	100	5 of 5
66794	ubiquinone biosynthesis	100	7 of 7
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	hydrogen production	100	5 of 5
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	lipoate biosynthesis	100	5 of 5
66794	suberin monomers biosynthesis	100	2 of 2
66794	folate polyglutamylation	100	1 of 1
66794	ethanol fermentation	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	biotin biosynthesis	100	4 of 4
66794	palmitate biosynthesis	95.45	21 of 22
66794	starch degradation	90	9 of 10
66794	chorismate metabolism	88.89	8 of 9
66794	lipid A biosynthesis	88.89	8 of 9
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	valine metabolism	88.89	8 of 9
66794	isoleucine metabolism	87.5	7 of 8
66794	reductive acetyl coenzyme A pathway	85.71	6 of 7
66794	purine metabolism	81.91	77 of 94
66794	pentose phosphate pathway	81.82	9 of 11
66794	peptidoglycan biosynthesis	80	12 of 15
66794	threonine metabolism	80	8 of 10
66794	heme metabolism	78.57	11 of 14
66794	tetrahydrofolate metabolism	78.57	11 of 14
66794	molybdenum cofactor biosynthesis	77.78	7 of 9
66794	d-mannose degradation	77.78	7 of 9
66794	phenylalanine metabolism	76.92	10 of 13
66794	vitamin B1 metabolism	76.92	10 of 13
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	sulfopterin metabolism	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	butanoate fermentation	75	3 of 4
66794	CMP-KDO biosynthesis	75	3 of 4
66794	acetate fermentation	75	3 of 4
66794	methionine metabolism	73.08	19 of 26
66794	vitamin B6 metabolism	72.73	8 of 11
66794	sulfate reduction	69.23	9 of 13
66794	pyrimidine metabolism	68.89	31 of 45
66794	glutamate and glutamine metabolism	67.86	19 of 28
66794	serine metabolism	66.67	6 of 9
66794	glycolate and glyoxylate degradation	66.67	4 of 6
66794	octane oxidation	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	NAD metabolism	66.67	12 of 18
66794	glutathione metabolism	64.29	9 of 14
66794	gluconeogenesis	62.5	5 of 8
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	62.5	5 of 8
66794	alanine metabolism	62.07	18 of 29
66794	isoprenoid biosynthesis	61.54	16 of 26
66794	non-pathway related	60.53	23 of 38
66794	Entner Doudoroff pathway	60	6 of 10
66794	flavin biosynthesis	60	9 of 15
66794	glycolysis	58.82	10 of 17
66794	propanol degradation	57.14	4 of 7
66794	citric acid cycle	57.14	8 of 14
66794	CO2 fixation in Crenarchaeota	55.56	5 of 9
66794	leucine metabolism	53.85	7 of 13
66794	polyamine pathway	52.17	12 of 23
66794	histidine metabolism	51.72	15 of 29
66794	lipid metabolism	51.61	16 of 31
66794	degradation of sugar alcohols	50	8 of 16
66794	coenzyme M biosynthesis	50	5 of 10
66794	phenylmercury acetate degradation	50	1 of 2
66794	dTDPLrhamnose biosynthesis	50	4 of 8
66794	cysteine metabolism	50	9 of 18
66794	ketogluconate metabolism	50	4 of 8
66794	cis-vaccenate biosynthesis	50	1 of 2
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	lysine metabolism	47.62	20 of 42
66794	phosphatidylethanolamine bioynthesis	46.15	6 of 13
66794	urea cycle	46.15	6 of 13
66794	proline metabolism	45.45	5 of 11
66794	cholesterol biosynthesis	45.45	5 of 11
66794	oxidative phosphorylation	42.86	39 of 91
66794	tyrosine metabolism	42.86	6 of 14
66794	arginine metabolism	41.67	10 of 24
66794	propionate fermentation	40	4 of 10
66794	glycine metabolism	40	4 of 10
66794	glycine betaine biosynthesis	40	2 of 5
66794	tryptophan metabolism	36.84	14 of 38
66794	metabolism of disaccharids	36.36	4 of 11
66794	dolichyl-diphosphooligosaccharide biosynthesis	36.36	4 of 11
66794	degradation of aromatic, nitrogen containing compounds	33.33	4 of 12
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	IAA biosynthesis	33.33	1 of 3
66794	pantothenate biosynthesis	33.33	2 of 6
66794	nitrate assimilation	33.33	3 of 9
66794	enterobactin biosynthesis	33.33	1 of 3
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	sphingosine metabolism	33.33	2 of 6
66794	cyanate degradation	33.33	1 of 3
66794	phenylpropanoid biosynthesis	30.77	4 of 13
66794	degradation of hexoses	27.78	5 of 18
66794	ascorbate metabolism	27.27	6 of 22
66794	3-phenylpropionate degradation	26.67	4 of 15
66794	carnitine metabolism	25	2 of 8
66794	lactate fermentation	25	1 of 4
66794	vitamin E metabolism	25	1 of 4
66794	toluene degradation	25	1 of 4
66794	methanogenesis from CO2	25	3 of 12
66794	degradation of pentoses	25	7 of 28
66794	cyclohexanol degradation	25	1 of 4
66794	arachidonic acid metabolism	22.22	4 of 18

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Other	#Mine
#Condition	#Acidic	-

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
5597	acid, bituminous coal mine effluent	Pennsylvania	USA	USA	North America

Taxonmaps

69479

Global distribution of 16S sequence AF465604 (>99% sequence identity) for Acidithiobacillus from Microbeatlas

Aquatic Samples	493
Soil Samples	100
Animal Samples	74
Plant Samples	6
Total Samples	673

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
5597	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM2148v1 assembly for Acidithiobacillus ferrooxidans ATCC 23270	complete	GCA_000021485	243159.4	643348501	243159	96.68
124043	AFEATCC23270_v5.2 assembly for Acidithiobacillus ferrooxidans ATCC 23270	complete	GCA_049532655			920	95.14

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Acidithiobacillus ferrooxidans gene, 16S-23S rDNA region, strain: ATCC 23270	AB189135	441	920
20218	Acidithiobacillus ferrooxidans 16S ribosomal RNA gene, partial sequence	AF329205	1451	920
20218	Acidithiobacillus ferrooxidans strain ATCC23270 16S ribosomal RNA gene, partial sequence	AF465604	1461	920
20218	Acidithiobacillus ferrooxidans strain ATCC 23270 16S ribosomal RNA gene, partial sequence; intergenic spacer, tRNA-Ile (trnI) and tRNA-Ala (trnA) genes, complete sequence; and 23S ribosomal RNA gene, partial sequence	AF512809	497	920
20218	Acidithiobacillus ferrooxidans partial 16S rRNA gene, strain ATCC23270T	AJ278718	1342	920
20218	Acidithiobacillus ferrooxidans strain ATCC 23270 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence	EF059766	610	920
20218	Acidithiobacillus ferrooxidans 16S ribosomal RNA (16S rRNA), complete sequence	AH001792	274	920
124043	Acidithiobacillus thiooxidans strain DAMS 16S ribosomal RNA gene, partial sequence; intergenic spacer, tRNA-Ile (trnI) and tRNA-Ala (trnA) genes, complete sequence; and 23S ribosomal RNA gene, partial sequence.	AF512810	508	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059763	629	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059764	617	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059765	633	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059767	611	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059768	619	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059769	621	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059770	610	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059771	603	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059772	617	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059773	628	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059774	612	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059775	591	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059776	602	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059777	604	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059778	615	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059779	624	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059780	619	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059781	590	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059782	616	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059783	621	920
124043	Acidithiobacillus thiooxidans strain TSK-3 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence.	EF059784	610	920
5597	Thiobacillus ferrooxidans 16S rRNA sequence	M79404	279	920

GC content

@ref	GC-content (mol%)	Method
5597	58-59
5597	58.8	sequence analysis

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM2148v1 assembly for Acidithiobacillus ferrooxidans ATCC 23270
BV-BRC: 243159.4

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate anaerobe	51.75	no
125439	gram_stain	BacteriaNetⓘ	negative	81.11	no
125439	motility	BacteriaNetⓘ	yes	57.41	no
125439	spore_formation	BacteriaNetⓘ	no	97.14	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Acidithiobacillus ferrooxidans ATCC 23270 ATCC 23270
NCBI: GCA_000021485.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	96.55	no
125438	anaerobic	anaerobicⓘ	no	78.76	no
125438	aerobic	aerobicⓘ	yes	51.09	no
125438	spore-forming	spore-formingⓘ	no	91.19	no
125438	thermophilic	thermophileⓘ	no	92.33	no
125438	flagellated	motile2+ⓘ	no	70.39	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	CRISPR/dCas12a knock-down of Acidithiobacillus ferrooxidans electron transport chain bc₁ complexes enables enhanced metal sulfide bioleaching.	Jung H, Inaba Y, Banta S.	J Biol Chem	10.1016/j.jbc.2024.107703	2024
Transcriptome	Characterize the Growth and Metabolism of Acidithiobacillus ferrooxidans under Electroautotrophic and Chemoautotrophic Conditions.	Wang Q, Long H, Wang H, Lau Vetter MCY.	Microorganisms	10.3390/microorganisms12030590	2024
	Computational structure prediction provides a plausible mechanism for electron transfer by the outer membrane protein Cyc2 from Acidithiobacillus ferrooxidans.	Jiang V, Khare SD, Banta S.	Protein Sci	10.1002/pro.4106	2021
Enzymology	A widely distributed hydrogenase oxidises atmospheric H₂ during bacterial growth.	Islam ZF, Welsh C, Bayly K, Grinter R, Southam G, Gagen EJ, Greening C.	ISME J	10.1038/s41396-020-0713-4	2020
	Application of double-pulse laser-induced breakdown spectroscopy (DP-LIBS), Fourier transform infrared micro-spectroscopy and Raman microscopy for the characterization of copper-sulfides.	Varotsis C, Tselios C, Yiannakkos KA, Andreou C, Papageorgiou M, Nicolaides A.	RSC Adv	10.1039/d1ra07189k	2021
	U mobilization and associated U isotope fractionation by sulfur-oxidizing bacteria.	Rosendahl CD, Roebbert Y, Schippers A, Weyer S.	Front Microbiol	10.3389/fmicb.2023.1190962	2023
	Biomachining: Preservation of Acidithiobacillus ferrooxidans and treatment of the liquid residue.	Diaz-Tena E, Rojo N, Gurtubay L, Rodriguez-Ezquerro A, Lopez de Lacalle LN, Oyanguren I, Barbero F, Elias A.	Eng Life Sci	10.1002/elsc.201600124	2017
Metabolism	Improved experimental and computational methodology for determining the kinetic equation and the extant kinetic constants of Fe(II) oxidation by Acidithiobacillus ferrooxidans.	Molchanov S, Gendel Y, Ioslvich I, Lahav O.	Appl Environ Microbiol	10.1128/aem.01521-06	2007
	Simple absolute quantification method correcting for quantitative PCR efficiency variations for microbial community samples.	Brankatschk R, Bodenhausen N, Zeyer J, Burgmann H.	Appl Environ Microbiol	10.1128/aem.07878-11	2012
	Adaptive response of the holdase chaperone network of Acidithiobacillus ferrooxidans ATCC 23270 to stresses and energy sources	Izquierdo-Fiallo K, Munoz-Villagran C, Schimpf C, Mardonez MP, Rafaja D, Schlomann M, Tello M, Orellana O, Levican G.	World J Microbiol Biotechnol.		2025
	Adaptive response of the holdase chaperone network of Acidithiobacillus ferrooxidans ATCC 23270 to stresses and energy sources.	Izquierdo-Fiallo K, Munoz-Villagran C, Schimpf C, Mardonez MP, Rafaja D, Schlomann M, Tello M, Orellana O, Levican G.	World J Microbiol Biotechnol	10.1007/s11274-025-04325-7	2025
Enzymology	Overexpression of sulfide:quinone reductase (SQR) in Acidithiobacillus ferrooxidans enhances sulfur, pyrite, and pyrrhotite oxidation.	Jung H, Inaba Y, Banta S.	Appl Environ Microbiol	10.1128/aem.00170-25	2025
	Interplay between desiccation and oxidative stress responses in iron-oxidizing acidophilic bacteria.	Claudia MV, Javiera AA, Sebastian NS, Jose FR, Gloria L.	J Biotechnol	10.1016/j.jbiotec.2024.01.017	2024
	Simulating compatible solute biosynthesis using a metabolic flux model of the biomining acidophile, Acidithiobacillus ferrooxidans ATCC 23270.	Khaleque HN, Nazem-Bokaee H, Gumulya Y, Carlson RP, Kaksonen AH.	Res Microbiol	10.1016/j.resmic.2023.104115	2024
	Bioleaching of sludge from acid-leached waste traction batteries used in electric vehicles for the extraction of Ni and Co using optimized microbial consortia.	Lu H, Zhang H, Chen X, Wang L, Yan X.	RSC Adv	10.1039/d5ra07472j	2025
Genetics	Significant differences in the degree of genomic DNA N6-methyladenine modifications in Acidithiobacillus ferrooxidans with two different culture substrates.	Lin R, Liu J, Shan S, Zhang Y, Yang Y.	PLoS One	10.1371/journal.pone.0298204	2024
Transcriptome	Different fates of Sb(III) and Sb(V) during the formation of jarosite mediated by Acidithiobacillus ferrooxidans.	Chen L, Wang Y, Liu H, Zhou Y, Nie Z, Xia J, Shu W.	J Environ Sci (China)	10.1016/j.jes.2023.12.006	2025
	Biocompatibility Research of Magnetosomes Synthesized by Acidithiobacillus ferrooxidans.	Wu BQ, Wang J, Liu Y, Yang BJ, Li HY, Zhao CX, Qiu GZ.	Int J Mol Sci	10.3390/ijms26094278	2025
	Bioleaching as an Eco-Friendly Nano-Factory for Sustainable Inorganic Waste Management: Current Advancements, Challenges, and Opportunities.	Jaiswal A, Raj SI, Isiaka Adetunji A, Negadi L, Singh S, Tumba K, Bahadur I, Uddin I.	ChemistryOpen	10.1002/open.202500104	2025
	Utilization of Algal Biochar for Biopassivation of Copper Sulfide Tailings to Reduce Acid Mine Drainage.	Peng Z, Liu C, Fu Y, Liu H, Liu H, Cao H.	Biology (Basel)	10.3390/biology14030300	2025
Genetics	MOBHunter: a data integration platform for identification and classification of mobile genetic elements in microbial genomes.	Rojas-Villalobos C, Ossandon FJ, Castillo-Vilcahuaman C, Sepulveda-Rebolledo P, Castro-Salinas D, Zapata-Araya A, Arisan D, Perez-Acle T, Issotta F, Quatrini R, Moya-Beltran A.	Nucleic Acids Res	10.1093/nar/gkaf396	2025
Transcriptome	Fe/S Redox-Coupled Mercury Transformation Mediated by Acidithiobacillus ferrooxidans ATCC 23270 under Aerobic and/or Anaerobic Conditions.	Liu Y, Gu C, Liu H, Zhou Y, Nie Z, Wang Y, Chen L, Xia J.	Microorganisms	10.3390/microorganisms11041028	2023
Biotechnology	Novel metal sites revealed by spectroscopic and structural characterization of the ferric uptake regulator from Acidithiobacillus ferrooxidans.	Argandona Y, Olivos A, Obando P, Imas F, Pohl E, Quatrini R, Arenas-Salinas M.	Comput Struct Biotechnol J	10.1016/j.csbj.2025.02.017	2025
	Rare Earth Element Extraction from Ionic Rare Earth Ores by Two Typical Acidogenic Microorganisms, Aspergillus niger and Acidithiobacillus ferrooxidans.	Wang M, Li J, Liu H, Huang S, Liu X, Liu Y, Awais M, Wang J.	Int J Mol Sci	10.3390/ijms26051986	2025
Genetics	Genome sequencing and metabolic network reconstruction of a novel sulfur-oxidizing bacterium Acidithiobacillus Ameehan.	Wu P, Yuan Q, Cheng T, Han Y, Zhao W, Liao X, Wang L, Cai J, He Q, Guo Y, Zhang X, Lu F, Wang J, Ma H, Huang Z.	Front Microbiol	10.3389/fmicb.2023.1277847	2023
	Characterization and genomic analysis of two novel psychrotolerant Acidithiobacillus ferrooxidans strains from polar and subpolar environments.	Munoz-Villagran C, Grossolli-Galvez J, Acevedo-Arbunic J, Valenzuela X, Ferrer A, Diez B, Levican G.	Front Microbiol	10.3389/fmicb.2022.960324	2022
	The effect of calcium on the removal of Cd²⁺ in the formation of biogenic secondary iron minerals.	Geng K, Wang C, Wu X, Wei C, Huang H.	Sci Rep	10.1038/s41598-024-72764-7	2024
	Roles and Regulation of Quorum Sensing of Acidophiles in Bioleaching: A Review.	Luo W, Li Y, Chen S, Liang Y, Liu X.	Microorganisms	10.3390/microorganisms12030422	2024
Metabolism	Comparative Genomics of Sigma Factors in Acidithiobacillia Sheds Light into the Transcriptional Regulatory Networks Involved in Biogeochemical Dynamics in Extreme Acidic Environments.	Sepulveda-Rebolledo P, Gonzalez-Rosales C, Dopson M, Perez-Rueda E, Holmes DS, Valdes JH.	Microorganisms	10.3390/microorganisms13061199	2025
Metabolism	Glutathione Synthetase Overexpression in Acidithiobacillus ferrooxidans Improves Halotolerance of Iron Oxidation.	Inaba Y, West AC, Banta S.	Appl Environ Microbiol	10.1128/aem.01518-21	2021
	Phenomic and transcriptomic analyses reveal the sequential synthesis of Fe₃O₄ nanoparticles in Acidithiobacillus ferrooxidans BYM.	Yang J, Zhang S, Zhang Y, Zhao D, Liu T, Sun X, Yan L.	Microbiol Spectr	10.1128/spectrum.01729-23	2023
Genetics	Comparative genomics reveals intraspecific divergence of Acidithiobacillus ferrooxidans: insights from evolutionary adaptation.	Liu R, Ma L, Wang H, Liu D, Lu X, Huang X, Huang S, Liu X.	Microb Genom	10.1099/mgen.0.001038	2023
Enzymology	Sulfur enhancement effects for uranium bioleaching in column reactors from a refractory uranium ore.	Li Q, Yang Y, Ma J, Sun J, Li G, Zhang R, Cui Z, Li T, Liu X.	Front Microbiol	10.3389/fmicb.2023.1107649	2023
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Genetics	Whole genome sequence analysis reveals high genetic variation of newly isolated Acidithiobacillus ferrooxidans IO-2C.	Fariq A, Blazier JC, Yasmin A, Gentry TJ, Deng Y.	Sci Rep	10.1038/s41598-019-49213-x	2019
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Genetics	Complete Genome Sequence of Acidithiobacillus Ferrooxidans YNTRS-40, a Strain of the Ferrous Iron- and Sulfur-Oxidizing Acidophile.	Zhang Y, Zhang S, Zhao D, Ni Y, Wang W, Yan L.	Microorganisms	10.3390/microorganisms8010002	2019
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Genetics	Genomic insights into key mechanisms for carbon, nitrogen, and phosphate assimilation by the acidophilic, halotolerant genus Acidihalobacter members.	Khaleque HN, Fathollahzadeh H, Kaksonen AH, Valdes J, Vergara E, Holmes DS, Watkin ELJ.	FEMS Microbiol Ecol	10.1093/femsec/fiae145	2024
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Genetics	Integrative Assessments on Molecular Taxonomy of Acidiferrobacter thiooxydans ZJ and Its Environmental Adaptation Based on Mobile Genetic Elements.	Ma L, Yang W, Huang S, Liu R, Li H, Huang X, Xiong J, Liu X.	Front Microbiol	10.3389/fmicb.2022.826829	2022
Metabolism	The substrate-dependent regulatory effects of the AfeI/R system in Acidithiobacillus ferrooxidans reveals the novel regulation strategy of quorum sensing in acidophiles.	Gao XY, Fu CA, Hao L, Gu XF, Wang R, Lin JQ, Liu XM, Pang X, Zhang CJ, Lin JQ, Chen LX.	Environ Microbiol	10.1111/1462-2920.15163	2021
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Pathogenicity	Determinants of Copper Resistance in Acidithiobacillus Ferrivorans ACH Isolated from the Chilean Altiplano.	Barahona S, Castro-Severyn J, Dorador C, Saavedra C, Remonsellez F.	Genes (Basel)	10.3390/genes11080844	2020
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Metabolism	Defining sequence space and reaction products within the cyanuric acid hydrolase (AtzD)/barbiturase protein family.	Seffernick JL, Erickson JS, Cameron SM, Cho S, Dodge AG, Richman JE, Sadowsky MJ, Wackett LP.	J Bacteriol	10.1128/jb.00791-12	2012
	Phosphate Favors the Biosynthesis of CdS Quantum Dots in Acidithiobacillus thiooxidans ATCC 19703 by Improving Metal Uptake and Tolerance.	Ulloa G, Quezada CP, Araneda M, Escobar B, Fuentes E, Alvarez SA, Castro M, Bruna N, Espinoza-Gonzalez R, Bravo D, Perez-Donoso JM.	Front Microbiol	10.3389/fmicb.2018.00234	2018
	Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia.	Moya-Beltran A, Makarova KS, Acuna LG, Wolf YI, Covarrubias PC, Shmakov SA, Silva C, Tolstoy I, Johnson DB, Koonin EV, Quatrini R.	CRISPR J	10.1089/crispr.2021.0051	2021
Metabolism	Characterization of the petI and res operons of Acidithiobacillus ferrooxidans.	Levican G, Bruscella P, Guacunano M, Inostroza C, Bonnefoy V, Holmes DS, Jedlicki E.	J Bacteriol	10.1128/jb.184.5.1498-1501.2002	2002
	Nickel-resistance determinants in Acidiphilium sp. PM identified by genome-wide functional screening.	San Martin-Uriz P, Mirete S, Alcolea PJ, Gomez MJ, Amils R, Gonzalez-Pastor JE.	PLoS One	10.1371/journal.pone.0095041	2014
Metabolism	Microbial iron management mechanisms in extremely acidic environments: comparative genomics evidence for diversity and versatility.	Osorio H, Martinez V, Nieto PA, Holmes DS, Quatrini R.	BMC Microbiol	10.1186/1471-2180-8-203	2008
	An alternative path for the evolution of biological nitrogen fixation.	Boyd ES, Hamilton TL, Peters JW.	Front Microbiol	10.3389/fmicb.2011.00205	2011
Phylogeny	Annotation and Classification of CRISPR-Cas Systems.	Makarova KS, Koonin EV.	Methods Mol Biol	10.1007/978-1-4939-2687-9_4	2015
	ISAfe1, an ISL3 family insertion sequence from Acidithiobacillus ferrooxidans ATCC 19859.	Holmes DS, Zhao HL, Levican G, Ratouchniak J, Bonnefoy V, Varela P, Jedlicki E.	J Bacteriol	10.1128/jb.183.14.4323-4329.2001	2001
Metabolism	Discovery of a new subgroup of sulfur dioxygenases and characterization of sulfur dioxygenases in the sulfur metabolic network of Acidithiobacillus caldus.	Wu W, Pang X, Lin J, Liu X, Wang R, Lin J, Chen L.	PLoS One	10.1371/journal.pone.0183668	2017
Metabolism	Regulation of a glutamyl-tRNA synthetase by the heme status.	Levican G, Katz A, de Armas M, Nunez H, Orellana O.	Proc Natl Acad Sci U S A	10.1073/pnas.0611611104	2007
Enzymology	Phylogeny and functional expression of ribulose 1,5-bisphosphate carboxylase/oxygenase from the autotrophic ammonia-oxidizing bacterium Nitrosospira sp. isolate 40KI.	Utaker JB, Andersen K, Aakra A, Moen B, Nes IF.	J Bacteriol	10.1128/jb.184.2.468-478.2002	2002
	Tn7 elements: engendering diversity from chromosomes to episomes.	Parks AR, Peters JE.	Plasmid	10.1016/j.plasmid.2008.09.008	2009
Metabolism	Isolation and characterization of the small subunit of the uptake hydrogenase from the cyanobacterium Nostoc punctiforme.	Raleiras P, Kellers P, Lindblad P, Styring S, Magnuson A.	J Biol Chem	10.1074/jbc.m113.468587	2013
	Complete genome sequence of Thioalkalivibrio sp. K90mix.	Muyzer G, Sorokin DY, Mavromatis K, Lapidus A, Foster B, Sun H, Ivanova N, Pati A, D'haeseleer P, Woyke T, Kyrpides NC.	Stand Genomic Sci	10.4056/sigs.2315092	2011
Phylogeny	TIGRFAMs and Genome Properties in 2013.	Haft DH, Selengut JD, Richter RA, Harkins D, Basu MK, Beck E.	Nucleic Acids Res	10.1093/nar/gks1234	2013
Genetics	Gene Loss and Horizontal Gene Transfer Contributed to the Genome Evolution of the Extreme Acidophile "Ferrovum".	Ullrich SR, Gonzalez C, Poehlein A, Tischler JS, Daniel R, Schlomann M, Holmes DS, Muhling M.	Front Microbiol	10.3389/fmicb.2016.00797	2016
Metabolism	Factors influencing the identification of transcription factor binding sites by cross-species comparison.	McCue LA, Thompson W, Carmack CS, Lawrence CE.	Genome Res	10.1101/gr.323602	2002
	Evolution and classification of the CRISPR-Cas systems.	Makarova KS, Haft DH, Barrangou R, Brouns SJ, Charpentier E, Horvath P, Moineau S, Mojica FJ, Wolf YI, Yakunin AF, van der Oost J, Koonin EV.	Nat Rev Microbiol	10.1038/nrmicro2577	2011
Metabolism	Coevolution of an aminoacyl-tRNA synthetase with its tRNA substrates.	Salazar JC, Ahel I, Orellana O, Tumbula-Hansen D, Krieger R, Daniels L, Soll D.	Proc Natl Acad Sci U S A	10.1073/pnas.1936123100	2003
	Computational Metabolomics Operations at BioCyc.org.	Karp PD, Billington R, Holland TA, Kothari A, Krummenacker M, Weaver D, Latendresse M, Paley S.	Metabolites	10.3390/metabo5020291	2015
Metabolism	Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group.	Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR.	J Biol Chem	10.1074/jbc.m400597200	2004
Metabolism	Metabolic reconstruction of sulfur assimilation in the extremophile Acidithiobacillus ferrooxidans based on genome analysis.	Valdes J, Veloso F, Jedlicki E, Holmes D.	BMC Genomics	10.1186/1471-2164-4-51	2003
	Comparative genomics of freshwater Fe-oxidizing bacteria: implications for physiology, ecology, and systematics.	Emerson D, Field EK, Chertkov O, Davenport KW, Goodwin L, Munk C, Nolan M, Woyke T.	Front Microbiol	10.3389/fmicb.2013.00254	2013
Enzymology	Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity.	Yutin N, Koonin EV.	Biol Direct	10.1186/1745-6150-4-51	2009
	An updated evolutionary classification of CRISPR-Cas systems.	Makarova KS, Wolf YI, Alkhnbashi OS, Costa F, Shah SA, Saunders SJ, Barrangou R, Brouns SJ, Charpentier E, Haft DH, Horvath P, Moineau S, Mojica FJ, Terns RM, Terns MP, White MF, Yakunin AF, Garrett RA, van der Oost J, Backofen R, Koonin EV.	Nat Rev Microbiol	10.1038/nrmicro3569	2015
Genetics	Traceability, reproducibility and wiki-exploration for "à-la-carte" reconstructions of genome-scale metabolic models.	Aite M, Chevallier M, Frioux C, Trottier C, Got J, Cortes MP, Mendoza SN, Carrier G, Dameron O, Guillaudeux N, Latorre M, Loira N, Markov GV, Maass A, Siegel A.	PLoS Comput Biol	10.1371/journal.pcbi.1006146	2018
Metabolism	Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon-phosphorus lyase.	Hove-Jensen B, Zechel DL, Jochimsen B.	Microbiol Mol Biol Rev	10.1128/mmbr.00040-13	2014
Metabolism	Identification of components of electron transport chains in the extremely thermoacidophilic crenarchaeon Metallosphaera sedula through iron and sulfur compound oxidation transcriptomes.	Auernik KS, Kelly RM.	Appl Environ Microbiol	10.1128/aem.01545-08	2008
Phylogeny	Evolutionary origins and diversification of proteobacterial mutualists.	Sachs JL, Skophammer RG, Bansal N, Stajich JE.	Proc Biol Sci	10.1098/rspb.2013.2146	2014
Metabolism	CO2-responsive expression and gene organization of three ribulose-1,5-bisphosphate carboxylase/oxygenase enzymes and carboxysomes in Hydrogenovibrio marinus strain MH-110.	Yoshizawa Y, Toyoda K, Arai H, Ishii M, Igarashi Y.	J Bacteriol	10.1128/jb.186.17.5685-5691.2004	2004
Phylogeny	A system to automatically classify and name any individual genome-sequenced organism independently of current biological classification and nomenclature.	Marakeby H, Badr E, Torkey H, Song Y, Leman S, Monteil CL, Heath LS, Vinatzer BA.	PLoS One	10.1371/journal.pone.0089142	2014
Genetics	Genomic organization of the acidophilic chemolithoautotrophic bacterium Thiobacillus ferrooxidans ATCC 21834.	Irazabal N, Marin I, Amils R.	J Bacteriol	10.1128/jb.179.6.1946-1950.1997	1997
Phylogeny	Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems.	Makarova KS, Aravind L, Wolf YI, Koonin EV.	Biol Direct	10.1186/1745-6150-6-38	2011
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
	Reduction of soluble iron and reductive dissolution of ferric iron-containing minerals by moderately thermophilic iron-oxidizing bacteria	Bridge TAM, Johnson DB.	Appl Environ Microbiol	10.1128/aem.64.6.2181-2186.1998	1998
Phylogeny	Bioinformatic characterization of the 4-Toluene Sulfonate Uptake Permease (TSUP) family of transmembrane proteins.	Shlykov MA, Zheng WH, Chen JS, Saier MH.	Biochim Biophys Acta	10.1016/j.bbamem.2011.12.005	2012
Enzymology	The TyrA family of aromatic-pathway dehydrogenases in phylogenetic context.	Song J, Bonner CA, Wolinsky M, Jensen RA.	BMC Biol	10.1186/1741-7007-3-13	2005
	Phylogeny Reconstruction with Alignment-Free Method That Corrects for Horizontal Gene Transfer.	Bromberg R, Grishin NV, Otwinowski Z.	PLoS Comput Biol	10.1371/journal.pcbi.1004985	2016
Phylogeny	Telling the whole story in a 10,000-genome world.	Beiko RG.	Biol Direct	10.1186/1745-6150-6-34	2011
Metabolism	In silico genome analysis of an acid mine drainage species, Acidiphilium multivorum, for potential commercial acetic acid production and biomining.	Micciche AC, Barabote RD, Dittoe DK, Ricke SC	J Environ Sci Health B	10.1080/03601234.2019.1710985	2020
Metabolism	A regulation mechanism for the promoter region of the pet II operon in Acidithiobacillus ferrooxidans ATCC23270.	Zhang L, Wang T, Yang Y, Yang JM	Biochem Biophys Res Commun	10.1016/j.bbrc.2020.09.088	2020
Biotechnology	High copper concentration reduces biofilm formation in Acidithiobacillus ferrooxidans by decreasing production of extracellular polymeric substances and its adherence to elemental sulfur.	Vargas-Straube MJ, Beard S, Norambuena R, Paradela A, Vera M, Jerez CA	J Proteomics	10.1016/j.jprot.2020.103874	2020
Metabolism	Early reprecipitation of sulfate salts in coal biodesulfurization processes using acidophilic chemolithotrophic bacteria.	Duarte Briceno PG, Caicedo Pineda GA, Marquez Godoy MA	World J Microbiol Biotechnol	10.1007/s11274-020-02855-w	2020
Metabolism	Arsenic(III) biotransformation to tooeleite associated with the oxidation of Fe(II) via Acidithiobacillus ferrooxidans.	Wang X, Li Q, Liao Q, Yan Y, Xia J, Lin Q, Wang Q, Liang Y	Chemosphere	10.1016/j.chemosphere.2020.126080	2020
Stress	Proteomics Reveal Enhanced Oxidative Stress Responses and Metabolic Adaptation in Acidithiobacillus ferrooxidans Biofilm Cells on Pyrite.	Bellenberg S, Huynh D, Poetsch A, Sand W, Vera M	Front Microbiol	10.3389/fmicb.2019.00592	2019
	The Type IV Secretion System of ICEAfe1: Formation of a Conjugative Pilus in Acidithiobacillus ferrooxidans.	Flores-Rios R, Moya-Beltran A, Pareja-Barrueto C, Arenas-Salinas M, Valenzuela S, Orellana O, Quatrini R	Front Microbiol	10.3389/fmicb.2019.00030	2019
	Possible Role of Envelope Components in the Extreme Copper Resistance of the Biomining Acidithiobacillus ferrooxidans.	Oetiker N, Norambuena R, Martinez-Bussenius C, Navarro CA, Amaya F, Alvarez SA, Paradela A, Jerez CA	Genes (Basel)	10.3390/genes9070347	2018
Metabolism	Identification and Analysis of a Novel Gene Cluster Involves in Fe(2+) Oxidation in Acidithiobacillus ferrooxidans ATCC 23270, a Typical Biomining Acidophile.	Ai C, Liang Y, Miao B, Chen M, Zeng W, Qiu G	Curr Microbiol	10.1007/s00284-018-1453-9	2018
Phylogeny	Functionality of tRNAs encoded in a mobile genetic element from an acidophilic bacterium.	Alamos P, Tello M, Bustamante P, Gutierrez F, Shmaryahu A, Maldonado J, Levican G, Orellana O	RNA Biol	10.1080/15476286.2017.1349049	2017
	Insights into the Quorum Sensing Regulon of the Acidophilic Acidithiobacillus ferrooxidans Revealed by Transcriptomic in the Presence of an Acyl Homoserine Lactone Superagonist Analog.	Mamani S, Moinier D, Denis Y, Soulere L, Queneau Y, Talla E, Bonnefoy V, Guiliani N	Front Microbiol	10.3389/fmicb.2016.01365	2016
Metabolism	Insights into the fluoride-resistant regulation mechanism of Acidithiobacillus ferrooxidans ATCC 23270 based on whole genome microarrays.	Ma L, Li Q, Shen L, Feng X, Xiao Y, Tao J, Liang Y, Yin H, Liu X	J Ind Microbiol Biotechnol	10.1007/s10295-016-1827-6	2016
Phylogeny	Missing Iron-Oxidizing Acidophiles Highly Sensitive to Organic Compounds.	Ueoka N, Kouzuma A, Watanabe K	Microbes Environ	10.1264/jsme2.ME16086	2016
Metabolism	Acidithiobacillus ferrooxidans's comprehensive model driven analysis of the electron transfer metabolism and synthetic strain design for biomining applications.	Campodonico MA, Vaisman D, Castro JF, Razmilic V, Mercado F, Andrews BA, Feist AM, Asenjo JA	Metab Eng Commun	10.1016/j.meteno.2016.03.003	2016
Genetics	A Comprehensive tRNA Genomic Survey Unravels the Evolutionary History of tRNA Arrays in Prokaryotes.	Tran TT, Belahbib H, Bonnefoy V, Talla E	Genome Biol Evol	10.1093/gbe/evv254	2015
Metabolism	Evidence of cell surface iron speciation of acidophilic iron-oxidizing microorganisms in indirect bioleaching process.	Nie ZY, Liu HC, Xia JL, Yang Y, Zhen XJ, Zhang LJ, Qiu GZ	Biometals	10.1007/s10534-015-9893-1	2015
Metabolism	Cytoplasmic CopZ-Like Protein and Periplasmic Rusticyanin and AcoP Proteins as Possible Copper Resistance Determinants in Acidithiobacillus ferrooxidans ATCC 23270.	Navarro CA, von Bernath D, Martinez-Bussenius C, Castillo RA, Jerez CA	Appl Environ Microbiol	10.1128/AEM.02810-15	2015
Pathogenicity	Toxin-antitoxin systems in the mobile genome of Acidithiobacillus ferrooxidans.	Bustamante P, Tello M, Orellana O	PLoS One	10.1371/journal.pone.0112226	2014
Metabolism	Response to copper of Acidithiobacillus ferrooxidans ATCC 23270 grown in elemental sulfur.	Almarcegui RJ, Navarro CA, Paradela A, Albar JP, von Bernath D, Jerez CA	Res Microbiol	10.1016/j.resmic.2014.07.005	2014
Enzymology	Identification and characterization of an ETHE1-like sulfur dioxygenase in extremely acidophilic Acidithiobacillus spp.	Wang H, Liu S, Liu X, Li X, Wen Q, Lin J	Appl Microbiol Biotechnol	10.1007/s00253-014-5830-4	2014
Pathogenicity	Heavy metal resistance strategies of acidophilic bacteria and their acquisition: importance for biomining and bioremediation.	Navarro CA, von Bernath D, Jerez CA	Biol Res	10.4067/S0716-97602013000400008	2013
Metabolism	New copper resistance determinants in the extremophile acidithiobacillus ferrooxidans: a quantitative proteomic analysis.	Almarcegui RJ, Navarro CA, Paradela A, Albar JP, von Bernath D, Jerez CA	J Proteome Res	10.1021/pr4009833	2014
Metabolism	Attachment of Acidithiobacillus ferrooxidans onto different solid substrates and fitting through Langmuir and Freundlich equations.	Xia LX, Shen Z, Vargas T, Sun WJ, Ruan RM, Xie ZD, Qiu GZ	Biotechnol Lett	10.1007/s10529-013-1316-1	2013
Pathogenicity	[Effect of simulated heavy metal leaching solution of electroplating sludge on the bioactivity of Acidithiobacillus ferrooxidans].	Xie XY, Sun PD, Lou JQ, Guo MX, Ma WG	Huan Jing Ke Xue		2013
Pathogenicity	ICE Afe 1, an actively excising genetic element from the biomining bacterium Acidithiobacillus ferrooxidans.	Bustamante P, Covarrubias PC, Levican G, Katz A, Tapia P, Holmes D, Quatrini R, Orellana O	J Mol Microbiol Biotechnol	10.1159/000346669	2013
Genetics	Type IV pili of Acidithiobacillus ferrooxidans can transfer electrons from extracellular electron donors.	Li Y, Li H	J Basic Microbiol	10.1002/jobm.201200300	2013
Phylogeny	Differential gene expression and bioinformatics analysis of copper resistance gene afe_1073 in Acidithiobacillus ferrooxidans.	Hu Q, Wu X, Jiang Y, Liu Y, Liang Y, Liu X, Yin H, Baba N	Biol Trace Elem Res	10.1007/s12011-012-9589-0	2013
Pathogenicity	Shotgun proteomics study of early biofilm formation process of Acidithiobacillus ferrooxidans ATCC 23270 on pyrite.	Vera M, Krok B, Bellenberg S, Sand W, Poetsch A	Proteomics	10.1002/pmic.201200386	2013
Enzymology	Tetrathionate-forming thiosulfate dehydrogenase from the acidophilic, chemolithoautotrophic bacterium Acidithiobacillus ferrooxidans.	Kikumoto M, Nogami S, Kanao T, Takada J, Kamimura K	Appl Environ Microbiol	10.1128/AEM.02251-12	2012
Enzymology	Cloning, expression and bioinformatics analysis of ATP sulfurylase from Acidithiobacillus ferrooxidans ATCC 23270 in Escherichia coli.	Jaramillo ML, Abanto M, Quispe RL, Calderon J, Del Valle LJ, Talledo M, Ramirez P	Bioinformation	10.6026/97320630008695	2012
Transcriptome	Global transcriptional analysis of stress-response strategies in Acidithiobacillus ferrooxidans ATCC 23270 exposed to organic extractant--Lix984n.	Zhou Z, Fang Y, Li Q, Yin H, Qin W, Liang Y, Li Q, Li N, Liu X, Qiu G, Liu X	World J Microbiol Biotechnol	10.1007/s11274-011-0903-3	2011
Metabolism	Cloning, expression, and functional analysis of molecular motor pilT and pilU genes of type IV pili in Acidithiobacillus ferrooxidans.	Li Y, Huang S, Zhang X, Huang T, Li H	Appl Microbiol Biotechnol	10.1007/s00253-012-4271-1	2012
Metabolism	Transcriptional and functional studies of a Cd(II)/Pb(II)-responsive transcriptional regulator(CmtR) from Acidithiobacillus ferrooxidans ATCC 23270.	Zheng C, Li Y, Nie L, Qian L, Cai L, Liu J	Curr Microbiol	10.1007/s00284-012-0117-4	2012
Cultivation	Development of a markerless gene replacement system for Acidithiobacillus ferrooxidans and construction of a pfkB mutant.	Wang H, Liu X, Liu S, Yu Y, Lin J, Lin J, Pang X, Zhao J	Appl Environ Microbiol	10.1128/AEM.07230-11	2011
Phylogeny	The small heat shock proteins from Acidithiobacillus ferrooxidans: gene expression, phylogenetic analysis, and structural modeling.	Ribeiro DA, Bem LE, Vicentini R, Ferraz LF, Murakami MT, Ottoboni LM	BMC Microbiol	10.1186/1471-2180-11-259	2011
Metabolism	The extremophile Acidithiobacillus ferrooxidans possesses a c-di-GMP signalling pathway that could play a significant role during bioleaching of minerals.	Ruiz LM, Castro M, Barriga A, Jerez CA, Guiliani N	Lett Appl Microbiol	10.1111/j.1472-765X.2011.03180.x	2011
	Growth of Acidithiobacillus Ferrooxidans ATCC 23270 in Thiosulfate Under Oxygen-Limiting Conditions Generates Extracellular Sulfur Globules by Means of a Secreted Tetrathionate Hydrolase.	Beard S, Paradela A, Albar JP, Jerez CA	Front Microbiol	10.3389/fmicb.2011.00079	2011
Metabolism	Genome wide identification of Acidithiobacillus ferrooxidans (ATCC 23270) transcription factors and comparative analysis of ArsR and MerR metal regulators.	Hodar C, Moreno P, di Genova A, Latorre M, Reyes-Jara A, Maass A, Gonzalez M, Cambiazo V	Biometals	10.1007/s10534-011-9484-8	2011
Pathogenicity	A genomic island provides Acidithiobacillus ferrooxidans ATCC 53993 additional copper resistance: a possible competitive advantage.	Orellana LH, Jerez CA	Appl Microbiol Biotechnol	10.1007/s00253-011-3494-x	2011
Metabolism	Sulfite oxidation catalyzed by aa(3)-type cytochrome c oxidase in Acidithiobacillus ferrooxidans.	Sugio T, Ako A, Takeuchi F	Biosci Biotechnol Biochem	10.1271/bbb.100446	2010
Pathogenicity	Cytoplasmic membrane response to copper and nickel in Acidithiobacillus ferrooxidans.	Mykytczuk NC, Trevors JT, Ferroni GD, Leduc LG	Microbiol Res	10.1016/j.micres.2010.03.004	2010
Enzymology	K30, H150, and H168 are essential residues for coordinating pyridoxal 5'-phosphate of O-acetylserine sulfhydrylase from Acidithiobacillus ferrooxidans.	Zheng C, Nie L, Qian L, Wang Z, Liu G, Liu J	Curr Microbiol	10.1007/s00284-009-9565-x	2009
Metabolism	Type IV pili of Acidithiobacillus ferrooxidans are necessary for sliding, twitching motility, and adherence.	Li YQ, Wan DS, Huang SS, Leng FF, Yan L, Ni YQ, Li HY	Curr Microbiol	10.1007/s00284-009-9494-8	2009
Metabolism	Cys92, Cys101, Cys197, and Cys203 are crucial residues for coordinating the iron-sulfur cluster of RhdA from Acidithiobacillus ferrooxidans.	Dai Y, Liu J, Zheng C, Wu A, Zeng J, Qiu G	Curr Microbiol	10.1007/s00284-009-9476-x	2009
Metabolism	Extending the models for iron and sulfur oxidation in the extreme acidophile Acidithiobacillus ferrooxidans.	Quatrini R, Appia-Ayme C, Denis Y, Jedlicki E, Holmes DS, Bonnefoy V	BMC Genomics	10.1186/1471-2164-10-394	2009
Enzymology	Preliminary X-ray crystallographic analysis of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans.	Zhang Y, Cherney MM, Solomonson M, Liu J, James MN, Weiner JH	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/S1744309109027535	2009
Metabolism	Ferrous iron production mediated by tetrathionate hydrolase in tetrathionate-, sulfur-, and iron-grown Acidithiobacillus ferrooxidans ATCC 23270 cells.	Sugio T, Taha TM, Takeuchi F	Biosci Biotechnol Biochem	10.1271/bbb.90036	2009
Phylogeny	Comparative genomic analysis of Acidithiobacillus ferrooxidans strains using the A. ferrooxidans ATCC 23270 whole-genome oligonucleotide microarray.	Luo H, Shen L, Yin H, Li Q, Chen Q, Luo Y, Liao L, Qiu G, Liu X	Can J Microbiol	10.1139/w08-158	2009
Genetics	Real-time PCR analysis of the heat-shock response of Acidithiobacillus ferrooxidans ATCC 23270.	Xiao S, Chao J, Wang W, Fang F, Qui G, Liu X	Folia Biol (Praha)	FB2009A0001	2009
Metabolism	[Response of genes for synthesizing the magnetic of Acidithiobacillus ferrooxidans to different concentration of Fe2+ stress].	Liu X, Wu H, Liu W, Li S	Sheng Wu Gong Cheng Xue Bao		2009
Genetics	A stoichiometric model of Acidithiobacillus ferrooxidans ATCC 23270 for metabolic flux analysis.	Hold C, Andrews BA, Asenjo JA	Biotechnol Bioeng	10.1002/bit.22183	2009
Metabolism	Investigation of elemental sulfur speciation transformation mediated by Acidithiobacillus ferrooxidans.	He H, Zhang CG, Xia JL, Peng AA, Yang Y, Jiang HC, Zheng L, Ma CY, Zhao YD, Nie ZY, Qiu GZ	Curr Microbiol	10.1007/s00284-008-9330-6	2008
Genetics	Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications.	Valdes J, Pedroso I, Quatrini R, Dodson RJ, Tettelin H, Blake R 2nd, Eisen JA, Holmes DS	BMC Genomics	10.1186/1471-2164-9-597	2008
Metabolism	Regulation of CO2 fixation gene expression in Acidithiobacillus ferrooxidans ATCC 23270 by Lix984n shock.	Wang W, Xiao S, Chao J, Chen Q, Qiu G, Liu X	J Microbiol Biotechnol	10.4014/jmb.0700.737	2008
Enzymology	Expression, purification, and characterization of iron-sulfur cluster assembly regulator IscR from Acidithiobacillus ferrooxidans.	Zeng J, Zhang K, Liu J, Qiu G	J Microbiol Biotechnol	8097	2008
Enzymology	Reconstitution of iron oxidase from sulfur-grown Acidithiobacillus ferrooxidans.	Taha TM, Kanao T, Takeuchi F, Sugio T	Appl Environ Microbiol	10.1128/AEM.00787-08	2008
Metabolism	Reduction of Hg2+ with reduced mammalian cytochrome c by cytochrome c oxidase purified from a mercury-resistant acidithiobacillus ferrooxidans strain, MON-1.	Sugio T, Fujii M, Ninomiya Y, Kanao T, Negishi A, Takeuchi F	Biosci Biotechnol Biochem	10.1271/bbb.80070	2008
Metabolism	In vitro assembly of [Fe4S4] cluster in high potential iron-sulfur protein from Acidithiobacillus ferrooxidans.	Zeng J, Jiang H, Geng M, Wang Y, Zhang X, Liu J, Qiu G	Curr Microbiol	10.1007/s00284-008-9170-4	2008
Phylogeny	ribB and ribBA genes from Acidithiobacillus ferrooxidans: expression levels under different growth conditions and phylogenetic analysis.	Knegt FH, Mello LV, Reis FC, Santos MT, Vicentini R, Ferraz LF, Ottoboni LM	Res Microbiol	10.1016/j.resmic.2008.04.002	2008
Phylogeny	Isolation and characterization of Acidithiobacillus ferrooxidans strain D3-2 active in copper bioleaching from a copper mine in Chile.	Sugio T, Wakabayashi M, Kanao T, Takeuchi F	Biosci Biotechnol Biochem	10.1271/bbb.70743	2008
Metabolism	The chemolithoautotroph Acidithiobacillus ferrooxidans can survive under phosphate-limiting conditions by expressing a C-P lyase operon that allows it to grow on phosphonates.	Vera M, Pagliai F, Guiliani N, Jerez CA	Appl Environ Microbiol	10.1128/AEM.02101-07	2008
Genetics	The genome sequence of the metal-mobilizing, extremely thermoacidophilic archaeon Metallosphaera sedula provides insights into bioleaching-associated metabolism.	Auernik KS, Maezato Y, Blum PH, Kelly RM	Appl Environ Microbiol	10.1128/AEM.02019-07	2007
Enzymology	Expression, purification and characterization of a high potential iron-sulfur protein from Acidithiobacillus ferrooxidans.	Zeng J, Jiang H, Liu Y, Liu J, Qiu G	Biotechnol Lett	10.1007/s10529-007-9612-2	2007
Metabolism	Increase in Fe2+-producing activity during growth of Acidithiobacillus ferrooxidans ATCC23270 on sulfur.	Sugio T, Taha TM, Kanao T, Takeuchi F	Biosci Biotechnol Biochem	10.1271/bbb.70253	2007
Metabolism	Penetration analysis of elements and bioleaching treatment of spent refractory for recycling.	Masafumi T, Masanori F	J Environ Sci (China)	10.1016/s1001-0742(07)60187-9	2007
	Periplasmic proteins of the extremophile Acidithiobacillus ferrooxidans: a high throughput proteomics analysis.	Chi A, Valenzuela L, Beard S, Mackey AJ, Shabanowitz J, Hunt DF, Jerez CA	Mol Cell Proteomics	10.1074/mcp.M700042-MCP200	2007
Enzymology	Expression, purification, and characterization of a [Fe2S2] cluster containing ferredoxin from Acidithiobacillus ferrooxidans.	Zeng J, Huang X, Liu Y, Liu J, Qiu G	Curr Microbiol	10.1007/s00284-007-9025-4	2007
Biotechnology	Identification of a gene encoding a tetrathionate hydrolase in Acidithiobacillus ferrooxidans.	Kanao T, Kamimura K, Sugio T	J Biotechnol	10.1016/j.jbiotec.2007.08.030	2007
Enzymology	Expression, purification and characterization of a cysteine desulfurase, IscS, from Acidithiobacillus ferrooxidans.	Zeng J, Zhang Y, Liu Y, Zhang X, Xia L, Liu J, Qiu G	Biotechnol Lett	10.1007/s10529-007-9491-6	2007
Metabolism	The IscA from Acidithiobacillus ferrooxidans is an iron-sulfur protein which assemble the [Fe4S4] cluster with intracellular iron and sulfur.	Zeng J, Geng M, Jiang H, Liu Y, Liu J, Qiu G	Arch Biochem Biophys	10.1016/j.abb.2007.03.024	2007
Metabolism	Differential expression of two bc1 complexes in the strict acidophilic chemolithoautotrophic bacterium Acidithiobacillus ferrooxidans suggests a model for their respective roles in iron or sulfur oxidation.	Bruscella P, Appia-Ayme C, Levican G, Ratouchniak J, Jedlicki E, Holmes DS, Bonnefoy V	Microbiology (Reading)	10.1099/mic.0.2006/000067-0	2007
Metabolism	The ferric iron uptake regulator (Fur) from the extreme acidophile Acidithiobacillus ferrooxidans.	Quatrini R, Lefimil C, Holmes DS, Jedlicki E	Microbiology (Reading)	10.1099/mic.0.27581-0	2005
Metabolism	The HiPIP from the acidophilic Acidithiobacillus ferrooxidans is correctly processed and translocated in Escherichia coli, in spite of the periplasm pH difference between these two micro-organisms.	Bruscella P, Cassagnaud L, Ratouchniak J, Brasseur G, Lojou E, Amils R, Bonnefoy V	Microbiology (Reading)	10.1099/mic.0.27476-0	2005
Metabolism	Identification of putative sulfurtransferase genes in the extremophilic Acidithiobacillus ferrooxidans ATCC 23270 genome: structural and functional characterization of the proteins.	Acosta M, Beard S, Ponce J, Vera M, Mobarec JC, Jerez CA	OMICS	10.1089/omi.2005.9.13	2005
Metabolism	Copper ions stimulate polyphosphate degradation and phosphate efflux in Acidithiobacillus ferrooxidans.	Alvarez S, Jerez CA	Appl Environ Microbiol	10.1128/AEM.70.9.5177-5182.2004	2004
Phylogeny	Differentiation of Acidithiobacillus ferrooxidans and A. thiooxidans strains based on 16S-23S rDNA spacer polymorphism analysis.	Bergamo RF, Novo MT, Verissimo RV, Paulino LC, Stoppe NC, Sato MI, Manfio GP, Prado PI, Garcia O Jr, Ottoboni LM	Res Microbiol	10.1016/j.resmic.2004.03.009	2004
Metabolism	Differential protein expression during growth of Acidithiobacillus ferrooxidans on ferrous iron, sulfur compounds, or metal sulfides.	Ramirez P, Guiliani N, Valenzuela L, Beard S, Jerez CA	Appl Environ Microbiol	10.1128/AEM.70.8.4491-4498.2004	2004
Phylogeny	Phylogenetic heterogeneity of the species Acidithiobacillus ferrooxidans.	Karavaiko GI, Turova TP, Kondrat'eva TF, Lysenko AM, Kolganova TV, Ageeva SN, Muntyan LN, Pivovarova TA	Int J Syst Evol Microbiol	10.1099/ijs.0.02319-0	2003
Metabolism	Numerical modeling of ferrous-ion oxidation rate in Acidithiobacillus ferrooxidans ATCC 23270: optimization of culture conditions through statistically designed experiments.	Abdel-Fattah YR, Abdel-Fattah WR, Zamilpa R, Pierce JR	Acta Microbiol Pol		2002
Enzymology	The bc(1) complex of the iron-grown acidophilic chemolithotrophic bacterium Acidithiobacillus ferrooxidans functions in the reverse but not in the forward direction. Is there a second bc(1) complex?	Brasseur G, Bruscella P, Bonnefoy V, Lemesle-Meunier D	Biochim Biophys Acta	10.1016/s0005-2728(02)00251-7	2002
Enzymology	Two Copies of form I RuBisCO genes in Acidithiobacillus ferrooxidans ATCC 23270.	Heinhorst S, Baker SH, Johnson DR, Davies PS, Cannon GC, Shively JM	Curr Microbiol	10.1007/s00284-001-0094-5	2002
Cultivation	Cytochromes c of Acidithiobacillus ferrooxidans.	Yarzabal A, Brasseur G, Bonnefoy V	FEMS Microbiol Lett	10.1111/j.1574-6968.2002.tb11130.x	2002
Metabolism	An exported rhodanese-like protein is induced during growth of Acidithiobacillus ferrooxidans in metal sulfides and different sulfur compounds.	Ramirez P, Toledo H, Guiliani N, Jerez CA	Appl Environ Microbiol	10.1128/AEM.68.4.1837-1845.2002	2002
Enzymology	Characterization of a new dihemic c(4)-type cytochrome isolated from Thiobacillus ferrooxidans.	Giudici-Orticoni MT, Leroy G, Nitschke W, Bruschi M	Biochemistry	10.1021/bi992846p	2000
Genetics	Functional analysis of gapped microbial genomes: amino acid metabolism of Thiobacillus ferrooxidans.	Selkov E, Overbeek R, Kogan Y, Chu L, Vonstein V, Holmes D, Silver S, Haselkorn R, Fonstein M	Proc Natl Acad Sci U S A	10.1073/pnas.97.7.3509	2000
Enzymology	Sulfur-binding protein of flagella of Thiobacillus ferrooxidans.	Ohmura N, Tsugita K, Koizumi JI, Saika H	J Bacteriol	10.1128/jb.178.19.5776-5780.1996	1996
	Mechanism of microbial flotation using Thiobacillus ferrooxidans for pyrite suppression.	Ohmura N, Kitamura K, Saiki H	Biotechnol Bioeng	10.1002/bit.260410611	1993
Metabolism	Thiobacillus ferrooxidans, a facultative hydrogen oxidizer.	Drobner E, Huber H, Stetter KO	Appl Environ Microbiol	10.1128/aem.56.9.2922-2923.1990	1990

References

#5597	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 14882
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Acidithiobacillus ferrooxidans (DSM 14882, ATCC 23270, NCIMB 8455)

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