Mannheimia granulomatis (DSM 19156, ATCC 49244, CIP 103433)

Name: Mannheimia granulomatis (DSM 19156, ATCC 49244, CIP 103433)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 11722

Type strain

Strain Designation 26

Culture col. no. DSM 19156 ATCC 49244 CIP 103433 CCUG 45422 26

NCBI tax ID(s) 1122190 85402

Special Collections DSMZ CCUG CIP

History <- CIP <- ATCC <- G. R. Carter; 26 CIP <- 1990, ATCC <- G.R. Carter: strain 26, Pasteurella haemolytica-like

Links

Mannheimia granulomatis 26 is a Gram-negative, rod-shaped animal pathogen that was isolated from cattle, subcutaneous granuloma.

Gram-negative rod-shaped animal pathogen genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 42378

ATCC 49244,CCUG 45422,CIP 103433,DSM 19156

@ref 20215

Last LPSN update 2026-02-09 11:20:38

Domain Bacteria

Phylum Pseudomonadota

Class Gammaproteobacteria

Order Pasteurellales

Family Pasteurellaceae

Genus Mannheimia

Species Mannheimia granulomatis

Full scientific name Mannheimia granulomatis (Ribeiro et al. 1990) Angen et al. 1999

Synonyms (1)

Pasteurella granulomatis

BacDive ID	Other strains from **Mannheimia granulomatis** (6)	Type strain
144852	M. granulomatis CCUG 26828, MCCM 01016
144891	M. granulomatis CCUG 26986, MCCM 00576
148005	M. granulomatis CCUG 34655
149813	M. granulomatis CCUG 38461
149821	M. granulomatis CCUG 38474
152346	M. granulomatis CCUG 46479

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
119729	negative	rod-shaped
125439	negative		92.9
125438			92.821
125438	negative		97.3

Colony morphology

7943

Incubation period2-3 days

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
7943	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
7943	BHI MEDIUM (DSMZ Medium 215)	Medium recipe at MediaDive	Name: BHI MEDIUM (DSMZ Medium 215) Composition: Brain heart infusion 37.0 g/l Distilled water
36558	MEDIUM 118 - for Pasteurella, Actinobacillus and Psychrobacter frigidicola		Distilled water make up to (1000.000 ml);Yeast extract (1.000 g);Tryptocasein soy agar (40.000 g)
119729	CIP Medium 72	Medium recipe at CIP
119729	CIP Medium 118-b	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
7943	positive	growth	37
36558	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	microaerophile	92.3

Spore formation

@ref	Spore formation	Confidence
125439		99.5
125438		92.23

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68377	17634 ChEBI	D-glucose	+	builds acid from	from API NH
68377	18257 ChEBI	ornithine	-	degradation	from API NH
68377	27897 ChEBI	tryptophan	-	energy source	from API NH
68377	16199 ChEBI	urea	-	hydrolysis	from API NH

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68377	35581 ChEBI	indole		from API NH

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68377	35581 ChEBI	indole	-	from API NH

Enzymes

@ref	Value	Activity	Ec
68377	alkaline phosphatase	+	3.1.3.1	from API NH
68377	gamma-glutamyltransferase	-	2.3.2.2	from API NH
68377	ornithine decarboxylase	-	4.1.1.17	from API NH
68377	proline-arylamidase	-	3.4.11.5	from API NH
68377	tryptophan deaminase	-	4.1.99.1	from API NH
68377	urease	-	3.5.1.5	from API NH

API NH

@ref	PEN	GLU	FRU	MAL	SAC	ODC	URE	LIP	PAL	beta GAL	ProA	GGT	IND
7943	+	+	-	+	-	-	-	+	+	-	-	-	-
7943	-	+	+	-	+	-	-	-	+	+	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Infection	#Inflammation	-
#Host	#Mammals	#Bovinae (Cow, Cattle)

Isolation

@ref	Sample type	Country	Country ISO 3 Code	Continent
7943	cattle, subcutaneous granuloma	Brazil	BRA	Middle and South America
56774	Cattle subcutaneous granuloma	Brazil	BRA	Middle and South America
119729	Animal, Cattle, subcutaneous granuloma	Brazil	BRA	Middle and South America

Interaction and safety

Risk assessment

@ref	Pathogenicity animal	Biosafety level	Biosafety level comment
7943		2	Risk group (German classification) According to TRBA 466
119729		1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM62110v1 assembly for Mannheimia granulomatis DSM 19156	scaffold	GCA_000621105	1122190.3	2556921673	1122190	76.93

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Mannheimia granulomatis strain ATCC 49244 16S ribosomal RNA gene, partial sequence	AY362913	1362		85402
7943	Mannheimia granulomatis strain ATCC 49244 16S ribosomal RNA gene, partial sequence	AF053902	1504		85402

GC content

7943

GC-content (mol%)39.2

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Mannheimia granulomatis DSM 19156
NCBI: GCA_000621105

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	microaerophile	92.30	no
125439	gram_stain	BacteriaNetⓘ	negative	92.90	no
125439	motility	BacteriaNetⓘ	no	79.90	no
125439	spore_formation	BacteriaNetⓘ	no	99.50	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Mannheimia granulomatis DSM 19156 DSM 19156
NCBI: GCA_000621105.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	97.30	no
125438	anaerobic	anaerobicⓘ	no	95.06	no
125438	aerobic	aerobicⓘ	no	74.20	no
125438	spore-forming	spore-formingⓘ	no	92.23	no
125438	thermophilic	thermophileⓘ	no	97.50	yes
125438	flagellated	motile2+ⓘ	no	92.82	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Eosinophilic granuloma with Splendore-Hoeppli material caused by Mannheimia granulomatis in a calf.	Kawashima Y, Takahashi H, Shimoo M, Tamamura Y, Ishikawa Y, Kadota K.	J Vet Med Sci	10.1292/jvms.15-0717	2016
	Development of a multiplex real-time PCR assay using two thermocycling platforms for detection of major bacterial pathogens associated with bovine respiratory disease complex from clinical samples.	Loy JD, Leger L, Workman AM, Clawson ML, Bulut E, Wang B.	J Vet Diagn Invest	10.1177/1040638718800170	2018
Enzymology	Rapid and accurate identification of human isolates of Pasteurella and related species by sequencing the sodA gene.	Gautier AL, Dubois D, Escande F, Avril JL, Trieu-Cuot P, Gaillot O.	J Clin Microbiol	10.1128/jcm.43.5.2307-2314.2005	2005
Enzymology	Mycoplasma detection by triplex real-time PCR in bronchoalveolar lavage fluid from bovine respiratory disease complex cases.	Cornelissen JB, de Bree FM, van der Wal FJ, Kooi EA, Koene MG, Bossers A, Smid B, Antonis AF, Wisselink HJ.	BMC Vet Res	10.1186/s12917-017-1023-6	2017
	Evaluation of a multiplex real-time PCR for detection of four bacterial agents commonly associated with bovine respiratory disease in bronchoalveolar lavage fluid.	Wisselink HJ, Cornelissen JBWJ, van der Wal FJ, Kooi EA, Koene MG, Bossers A, Smid B, de Bree FM, Antonis AFG.	BMC Vet Res	10.1186/s12917-017-1141-1	2017
	A Sensitive and Accurate Recombinase Polymerase Amplification Assay for Detection of the Primary Bacterial Pathogens Causing Bovine Respiratory Disease.	Conrad CC, Daher RK, Stanford K, Amoako KK, Boissinot M, Bergeron MG, Alexander T, Cook S, Ralston B, Zaheer R, Niu YD, McAllister T.	Front Vet Sci	10.3389/fvets.2020.00208	2020
Phylogeny	Taxonomic relationships of the [Pasteurella] haemolytica complex as evaluated by DNA-DNA hybridizations and 16S rRNA sequencing with proposal of Mannheimia haemolytica gen. nov., comb. nov., Mannheimia granulomatis comb. nov., Mannheimia glucosida sp. nov., Mannheimia ruminalis sp. nov. and Mannheimia varigena sp. nov.	Angen O, Mutters R, Caugant DA, Olsen JE, Bisgaard M	Int J Syst Bacteriol	10.1099/00207713-49-1-67	1999

References

#7943	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 19156
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#36558	; Curators of the CIP;
#56774	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 45422
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#68377	Automatically annotated from API NH .
#119729	Collection of Institut Pasteur ; Curators of the CIP; CIP 103433
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Mannheimia granulomatis (DSM 19156, ATCC 49244, CIP 103433)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

API NH

Isolation, sampling and environmental information

Isolation source categories

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_000621105

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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