Neisseria cinerea 194 is an obligate aerobe, mesophilic, Gram-negative prokaryote that was isolated from Nasopharynx.
Gram-negative coccus-shaped obligate aerobe mesophilic genome sequence 16S sequence| @ref 20215 |
|
|
| Domain Pseudomonadati |
| Phylum Pseudomonadota |
| Class Betaproteobacteria |
| Order Neisseriales |
| Family Neisseriaceae |
| Genus Neisseria |
| Species Neisseria cinerea |
| Full scientific name Neisseria cinerea (von Lingelsheim 1906) Murray 1939 (Approved Lists 1980) |
| Synonyms (1) |
| BacDive ID | Other strains from Neisseria cinerea (6) | Type strain |
|---|---|---|
| 141732 | N. cinerea CCUG 5746 | |
| 144598 | N. cinerea CCUG 25879 | |
| 144934 | N. cinerea CCUG 27178 A | |
| 144938 | N. cinerea CCUG 27182 | |
| 145479 | N. cinerea CCUG 28662 | |
| 154315 | N. cinerea CCUG 53043 B |
| @ref | Name | Growth | Medium link | Composition | |
|---|---|---|---|---|---|
| 1806 | COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) | Medium recipe at MediaDive | Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base | ||
| 42051 | MEDIUM 6 - Columbia agar with 10 % horse blood | Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml) | |||
| 118286 | CIP Medium 6 | Medium recipe at CIP |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 118286 | 15824 ChEBI | D-fructose | - | degradation | |
| 68377 | 15824 ChEBI | D-fructose | - | builds acid from | from API NH |
| 118286 | 17634 ChEBI | D-glucose | - | degradation | |
| 118286 | 17716 ChEBI | lactose | - | degradation | |
| 68377 | 17306 ChEBI | maltose | - | builds acid from | from API NH |
| 118286 | 17306 ChEBI | maltose | - | degradation | |
| 118286 | 17632 ChEBI | nitrate | - | builds gas from | |
| 118286 | 17632 ChEBI | nitrate | - | reduction | |
| 118286 | 17632 ChEBI | nitrate | - | respiration | |
| 118286 | 16301 ChEBI | nitrite | - | builds gas from | |
| 118286 | 16301 ChEBI | nitrite | + | reduction | |
| 68377 | 18257 ChEBI | ornithine | - | degradation | from API NH |
| 68377 | 17992 ChEBI | sucrose | - | builds acid from | from API NH |
| 118286 | 17992 ChEBI | sucrose | - | degradation | |
| 68377 | 27897 ChEBI | tryptophan | - | energy source | from API NH |
| 68377 | 16199 ChEBI | urea | - | hydrolysis | from API NH |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 118286 | alcohol dehydrogenase | - | 1.1.1.1 | |
| 68382 | alkaline phosphatase | - | 3.1.3.1 | from API zym |
| 68377 | alkaline phosphatase | - | 3.1.3.1 | from API NH |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | + | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 118286 | amylase | - | ||
| 68382 | beta-galactosidase | - | 3.2.1.23 | from API zym |
| 118286 | beta-galactosidase | - | 3.2.1.23 | |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 118286 | caseinase | - | 3.4.21.50 | |
| 1806 | catalase | + | 1.11.1.6 | |
| 118286 | catalase | + | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 1806 | cytochrome-c oxidase | + | 1.9.3.1 | |
| 118286 | DNase | - | ||
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | + | from API zym | |
| 118286 | gamma-glutamyltransferase | - | 2.3.2.2 | |
| 68377 | gamma-glutamyltransferase | - | 2.3.2.2 | from API NH |
| 118286 | gelatinase | - | ||
| 118286 | lecithinase | - | ||
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 118286 | lipase | - | ||
| 68377 | lipase | - | from API NH | |
| 68382 | lipase (C 14) | - | from API zym | |
| 118286 | lysine decarboxylase | - | 4.1.1.18 | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 118286 | ornithine decarboxylase | - | 4.1.1.17 | |
| 68377 | ornithine decarboxylase | - | 4.1.1.17 | from API NH |
| 118286 | oxidase | + | ||
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 68377 | tryptophan deaminase | - | 4.1.99.1 | from API NH |
| 118286 | tween esterase | - | ||
| 118286 | urease | - | 3.5.1.5 | |
| 68377 | urease | - | 3.5.1.5 | from API NH |
| 68382 | valine arylamidase | - | from API zym |
Global distribution of 16S sequence AB904035 (>99% sequence identity) for Neisseria from Microbeatlas ![]()
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 124043 | ASM1602871v1 assembly for Neisseria cinerea FDAARGOS_871 | complete | 483 | 98.27 | ||||
| 66792 | 43721_G02 assembly for Neisseria cinerea NCTC10294 | complete | 483 | 98 | ||||
| 124043 | ASM2102597v1 assembly for Neisseria cinerea CCUG 2156 | scaffold | 483 | 72.46 | ||||
| 66792 | ASM17389v1 assembly for Neisseria cinerea ATCC 14685 | contig | 546262 | 70.89 |
| 1806 | GC-content (mol%)49.0 |
| @ref | Trait | Model | Prediction | Confidence in % | In training data |
|---|---|---|---|---|---|
| 125439 | spore_formation | BacteriaNetⓘ | no | 99.20 | no |
| 125439 | motility | BacteriaNetⓘ | no | 78.60 | no |
| 125439 | gram_stain | BacteriaNetⓘ | negative | 85.10 | no |
| 125439 | oxygen_tolerance | BacteriaNetⓘ | obligate aerobe | 95.00 | no |
| @ref | Trait | Model | Prediction | Confidence in % | In training data |
|---|---|---|---|---|---|
| 125438 | gram-positive | gram-positiveⓘ | no | 100.00 | no |
| 125438 | anaerobic | anaerobicⓘ | no | 94.68 | yes |
| 125438 | aerobic | aerobicⓘ | yes | 54.59 | yes |
| 125438 | spore-forming | spore-formingⓘ | no | 90.67 | no |
| 125438 | thermophilic | thermophileⓘ | no | 97.98 | yes |
| 125438 | flagellated | motile2+ⓘ | no | 87.42 | no |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Enzymology | Microbiological evaluation of the new VITEK 2 Neisseria-Haemophilus identification card. | Valenza G, Ruoff C, Vogel U, Frosch M, Abele-Horn M. | J Clin Microbiol | 10.1128/jcm.00953-07 | 2007 | |
| Enzymology | Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs. | Wernecke M, Mullen C, Sharma V, Morrison J, Barry T, Maher M, Smith T. | BMC Infect Dis | 10.1186/1471-2334-9-148 | 2009 | |
| Bacteriocin-like peptides encoded by a horizontally acquired island mediate Neisseria gonorrhoeae autolysis. | Poncin K, McKeand SA, Lavender H, Kurzyp K, Harrison OB, Roberti A, Melia C, Johnson E, Maiden MCJ, Greaves DR, Exley R, Tang CM. | PLoS Biol | 10.1371/journal.pbio.3003001 | 2025 | ||
| Microbisporicin (NAI-107) protects Galleria mellonella from infection with Neisseria gonorrhoeae. | Hofkens N, Gestels Z, Abdellati S, De Baetselier I, Gabant P, Martin A, Kenyon C, Manoharan-Basil SS. | Microbiol Spectr | 10.1128/spectrum.02825-23 | 2023 | ||
| Two different and robustly modeled DNA binding modes of Competence Protein ComP - systematic modeling with AlphaFold 3, RoseTTAFold2NA, Chai-1 and re-docking in HADDOCK. | Helsem SA, Alfsnes K, Frye SA, Hesselberg Lovestad A, Ambur OH. | PLoS One | 10.1371/journal.pone.0315160 | 2025 | ||
| Phylogeny | Confirmation of the Need for Reclassification of Neisseria mucosa and Neisseria sicca Using Average Nucleotide Identity Blast and Phylogenetic Analysis of Whole-Genome Sequencing: Hinted by Clinical Misclassification of a Neisseria mucosa Strain. | Jin Y, Xu H, Yao Q, Gu B, Wang Z, Wang T, Yu X, Lu Y, Zheng B, Zhang Y. | Front Microbiol | 10.3389/fmicb.2021.780183 | 2021 | |
| Mobility of extracellular DNA within gonococcal colonies. | Bender N, Hennes M, Maier B. | Biofilm | 10.1016/j.bioflm.2022.100078 | 2022 | ||
| Multicenter Performance Evaluation of the Simplexa Bordetella Direct Kit in Nasopharyngeal Swab Specimens. | Chow SK, Arbefeville S, Boyanton BL, Dault EM, Dunn J, Ferrieri P, Greene W, Pence MA, Otiso J, Richter S, Schutzbank TE. | J Clin Microbiol | 10.1128/jcm.01041-20 | 2020 | ||
| Et tu, Neisseria? Conflicts of Interest Between Neisseria Species. | Baerentsen R, Tang CM, Exley RM. | Front Cell Infect Microbiol | 10.3389/fcimb.2022.913292 | 2022 | ||
| Role of Pneumocystis jirovecii in patients with different pulmonary underlying condition using a nested-PCR. | Martinez Lamas L, Perez Rodriguez MT, Alvarez Ramos I, Bouza Soage ME, Figueroa Lamas MP, Alvarez Fernandez M. | Rev Esp Quimioter | 2018 | |||
| Metabolism | Sequence-based predictions of lipooligosaccharide diversity in the Neisseriaceae and their implication in pathogenicity. | Stein DC, Miller CJ, Bhoopalan SV, Sommer DD. | PLoS One | 10.1371/journal.pone.0018923 | 2011 | |
| Rapid detection of the mosaic structure of the Neisseria gonorrhoeae penA Gene, which is associated with decreased susceptibilities to oral cephalosporins. | Ochiai S, Ishiko H, Yasuda M, Deguchi T. | J Clin Microbiol | 10.1128/jcm.01800-07 | 2008 | ||
| Conservation of meningococcal antigens in the genus Neisseria. | Muzzi A, Mora M, Pizza M, Rappuoli R, Donati C. | mBio | 10.1128/mbio.00163-13 | 2013 | ||
| Pathogenicity | A Natural Mouse Model for Neisseria Colonization. | Ma M, Powell DA, Weyand NJ, Rhodes KA, Rendon MA, Frelinger JA, So M. | Infect Immun | 10.1128/iai.00839-17 | 2018 | |
| Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection. | Pandey A, Cleary DW, Laver JR, Gorringe A, Deasy AM, Dale AP, Morris PD, Didelot X, Maiden MCJ, Read RC. | Nat Commun | 10.1038/s41467-018-07235-5 | 2018 | ||
| Profiling of Oral Microbiota in Early Childhood Caries Using Single-Molecule Real-Time Sequencing. | Wang Y, Zhang J, Chen X, Jiang W, Wang S, Xu L, Tu Y, Zheng P, Wang Y, Lin X, Chen H. | Front Microbiol | 10.3389/fmicb.2017.02244 | 2017 | ||
| Enzymology | Rapid detection of Brucella spp. in blood cultures by fluorescence in situ hybridization. | Wellinghausen N, Nockler K, Sigge A, Bartel M, Essig A, Poppert S. | J Clin Microbiol | 10.1128/jcm.44.5.1828-1830.2006 | 2006 | |
| Phylogeny | Dialects of the DNA uptake sequence in Neisseriaceae. | Frye SA, Nilsen M, Tonjum T, Ambur OH. | PLoS Genet | 10.1371/journal.pgen.1003458 | 2013 | |
| Metabolism | Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria. | Barth KR, Isabella VM, Clark VL. | Microbiology (Reading) | 10.1099/mic.0.032961-0 | 2009 | |
| Phylogeny | A genomic approach to bacterial taxonomy: an examination and proposed reclassification of species within the genus Neisseria. | Bennett JS, Jolley KA, Earle SG, Corton C, Bentley SD, Parkhill J, Maiden MCJ. | Microbiology (Reading) | 10.1099/mic.0.056077-0 | 2012 | |
| Phylogeny | Nitrate and the Origin of Saliva Influence Composition and Short Chain Fatty Acid Production of Oral Microcosms. | Koopman JE, Buijs MJ, Brandt BW, Keijser BJ, Crielaard W, Zaura E. | Microb Ecol | 10.1007/s00248-016-0775-z | 2016 | |
| Metabolism | Nosocomial pneumonia caused by a glucose-metabolizing strain of Neisseria cinerea. | Boyce JM, Taylor MR, Mitchell EB, Knapp JS. | J Clin Microbiol | 10.1128/jcm.21.1.1-3.1985 | 1985 | |
| Pathogenicity | Molecular Assay for Detection of Genetic Markers Associated with Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae. | Peterson SW, Martin I, Demczuk W, Bharat A, Hoang L, Wylie J, Allen V, Lefebvre B, Tyrrell G, Horsman G, Haldane D, Garceau R, Wong T, Mulvey MR. | J Clin Microbiol | 10.1128/jcm.00493-15 | 2015 | |
| Metabolism | Production of 14C-labeled gas in BACTEC Neisseria Differentiation kits by Neisseria cinerea. | Boyce JM, Mitchell EB, Knapp JS, Buttke TM. | J Clin Microbiol | 10.1128/jcm.22.3.416-418.1985 | 1985 | |
| Genetics | Metataxonomic and Metagenomic Approaches vs. Culture-Based Techniques for Clinical Pathology. | Hilton SK, Castro-Nallar E, Perez-Losada M, Toma I, McCaffrey TA, Hoffman EP, Siegel MO, Simon GL, Johnson WE, Crandall KA. | Front Microbiol | 10.3389/fmicb.2016.00484 | 2016 | |
| Genome sequencing reveals widespread virulence gene exchange among human Neisseria species. | Marri PR, Paniscus M, Weyand NJ, Rendon MA, Calton CM, Hernandez DR, Higashi DL, Sodergren E, Weinstock GM, Rounsley SD, So M. | PLoS One | 10.1371/journal.pone.0011835 | 2010 | ||
| Enzymology | Neisseria species identification assay for the confirmation of Neisseria gonorrhoeae-positive results of the COBAS Amplicor PCR. | Mangold KA, Regner M, Tajuddin M, Tajuddin AM, Jennings L, Du H, Kaul KL. | J Clin Microbiol | 10.1128/jcm.00834-06 | 2007 | |
| Enzymology | First report of performance of the Versant CT/GC DNA 1.0 assay (kPCR) for detection of Chlamydia trachomatis and Neisseria gonorrhoeae. | Kerndt PR, Ferrero DV, Aynalem G, Monga D, Wang S, Zhang N, Wong C, Liggins M, Meng Q. | J Clin Microbiol | 10.1128/jcm.01634-10 | 2011 | |
| Phylogeny | Difficulties in differentiating Neisseria cinerea from Neisseria gonorrhoeae in rapid systems used for identifying pathogenic Neisseria species. | Boyce JM, Mitchell EB. | J Clin Microbiol | 10.1128/jcm.22.5.731-734.1985 | 1985 | |
| Phylogeny | Characterization of Neisseria cinerea, a nonpathogenic species isolated on Martin-Lewis medium selective for pathogenic Neisseria spp. | Knapp JS, Totten PA, Mulks MH, Minshew BH. | J Clin Microbiol | 10.1128/jcm.19.1.63-67.1984 | 1984 | |
| Enzymology | Serologic confirmation of Neisseria gonorrhoeae by monoclonal antibody-based coagglutination procedures. | Anand CM, Gubash SM, Shaw H. | J Clin Microbiol | 10.1128/jcm.26.11.2283-2286.1988 | 1988 | |
| Phylogeny | Panel of reference strains for evaluating serologic reagents used to identify gonococci. | Evins GM, Pigott NE, Knapp JS, DeWitt WE. | J Clin Microbiol | 10.1128/jcm.26.2.354-357.1988 | 1988 | |
| Distribution of specific DNA sequences among pathogenic and commensal Neisseria species. | Aho EL, Murphy GL, Cannon JG. | Infect Immun | 10.1128/iai.55.4.1009-1013.1987 | 1987 | ||
| Enzymology | High levels of Gardnerella vaginalis detected with an oligonucleotide probe combined with elevated pH as a diagnostic indicator of bacterial vaginosis. | Sheiness D, Dix K, Watanabe S, Hillier SL. | J Clin Microbiol | 10.1128/jcm.30.3.642-648.1992 | 1992 | |
| Branhamella catarrhalis: an organism gaining respect as a pathogen. | Catlin BW. | Clin Microbiol Rev | 10.1128/cmr.3.4.293 | 1990 | ||
| Phylogeny | Virulence genes and previously unexplored gene clusters in four commensal Neisseria spp. isolated from the human throat expand the neisserial gene repertoire. | Calder A, Menkiti CJ, Cagdas A, Lisboa Santos J, Streich R, Wong A, Avini AH, Bojang E, Yogamanoharan K, Sivanesan N, Ali B, Ashrafi M, Issa A, Kaur T, Latif A, Mohamed HAS, Maqsood A, Tamang L, Swager E, Stringer AJ, Snyder LAS. | Microb Genom | 10.1099/mgen.0.000423 | 2020 | |
| Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation. | Bowler LD, Zhang QY, Riou JY, Spratt BG. | J Bacteriol | 10.1128/jb.176.2.333-337.1994 | 1994 | ||
| Enzymology | Comparative evaluation of AccuProbe culture identification test for Neisseria gonorrhoeae and other rapid methods. | Young H, Moyes A. | J Clin Microbiol | 10.1128/jcm.31.8.1996-1999.1993 | 1993 | |
| Phylogeny | Characterisation of Branhamella catarrhalis and differentiation from Neisseria species in a diagnostic laboratory. | Ahmad F, Young H, McLeod DT, Croughan MJ, Calder MA. | J Clin Pathol | 10.1136/jcp.40.11.1369 | 1987 | |
| Phylogeny | Diagnostics of neisseriaceae and moraxellaceae by ribosomal DNA sequencing: ribosomal differentiation of medical microorganisms. | Harmsen D, Singer C, Rothganger J, Tonjum T, de Hoog GS, Shah H, Albert J, Frosch M. | J Clin Microbiol | 10.1128/jcm.39.3.936-942.2001 | 2001 |
| #1806 | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 4630 |
| #20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 ) |
| #20218 | Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 ) |
| #42051 | ; Curators of the CIP; |
| #66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) . |
| #68377 | Automatically annotated from API NH . |
| #68382 | Automatically annotated from API zym . |
| #69479 | João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta . |
| #118286 | Collection of Institut Pasteur ; Curators of the CIP; CIP 73.16 |
| #124043 | Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy . |
| #125438 | Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 ) |
| #125439 | Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 . |
| #126262 | A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 ) |
You found an error in BacDive? Please tell us about it!
Note that changes will be reviewed and judged. If your changes are legitimate, changes will occur within the next BacDive update. Only proposed changes supported by the according reference will be reviewed. The BacDive team reserves the right to reject proposed changes.
Successfully sent
If you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive10466.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data