Strain identifier
BacDive ID: 6712
Type strain: 
Species: Legionella pneumophila
Strain Designation: Philadelphia-1
Strain history: CIP <- 1993, C. Tram, Inst. Pasteur, Paris, France <- ATCC <- R.E. Weaver, CDC: strain Philadelphia 1 <- J.E. McDade
NCBI tax ID(s): 1236535 (strain), 446 (species)
version 8.1 (current version)
General
@ref: 3193
BacDive-ID: 6712
DSM-Number: 7513
keywords: genome sequence, 16S sequence, Bacteria, microaerophile, mesophilic, Gram-negative, rod-shaped
description: Legionella pneumophila Philadelphia-1 is a microaerophile, mesophilic, Gram-negative bacterium that was isolated from human lung tissue.
NCBI tax id
| NCBI tax id | Matching level |
|---|---|
| 1236535 | strain |
| 446 | species |
strain history
| @ref | history |
|---|---|
| 3193 | <- ATCC <- R.E. Weaver, strain Philadelphia-1 |
| 67770 | GIFU 9134 <-- H. Kobayashi <-- ATCC 33152 <-- R. E. Weaver strain Philadelphia-1 <-- J. E. McDade. |
| 121898 | CIP <- 1993, C. Tram, Inst. Pasteur, Paris, France <- ATCC <- R.E. Weaver, CDC: strain Philadelphia 1 <- J.E. McDade |
doi: 10.13145/bacdive6712.20230509.8.1
Name and taxonomic classification
LPSN
- @ref: 20215
- description: domain/bacteria
- keyword: phylum/pseudomonadota
- domain: Bacteria
- phylum: Pseudomonadota
- class: Gammaproteobacteria
- order: Legionellales
- family: Legionellaceae
- genus: Legionella
- species: Legionella pneumophila
- full scientific name: Legionella pneumophila Brenner et al. 1979 (Approved Lists 1980)
@ref: 3193
domain: Bacteria
phylum: Proteobacteria
class: Gammaproteobacteria
order: Legionellales
family: Legionellaceae
genus: Legionella
species: Legionella pneumophila subsp. pneumophila
full scientific name: Legionella pneumophila subsp. pneumophila (Brenner et al. 1979) Brenner et al. 1989
strain designation: Philadelphia-1
type strain: yes
Morphology
cell morphology
- @ref: 121898
- gram stain: negative
- cell shape: rod-shaped
- motility: no
colony morphology
- @ref: 3193
- incubation period: 2-3 days
Culture and growth conditions
culture medium
| @ref | name | growth | link | composition |
|---|---|---|---|---|
| 3193 | BCYE-AGAR (DSMZ Medium 585) | yes | https://mediadive.dsmz.de/medium/585 | Name: BCYE AGAR (DSMZ Medium 585) Composition: OXOID Legionella CYE-Agar base |
| 40120 | MEDIUM 23 - for Afipia and Legionella | yes | Distilled water make up to (1000.000 ml);Legionella agar (37.000 g);Legionella - enrichment mixture (10.000 ml) | |
| 121898 | CIP Medium 72 | yes | https://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=72 | |
| 121898 | CIP Medium 23 | yes | https://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=23 |
culture temp
| @ref | growth | type | temperature | range |
|---|---|---|---|---|
| 3193 | positive | growth | 37 | mesophilic |
| 40120 | positive | growth | 37 | mesophilic |
| 67770 | positive | growth | 37 | mesophilic |
Physiology and metabolism
oxygen tolerance
| @ref | oxygen tolerance |
|---|---|
| 3193 | microaerophile |
| 45204 | microaerophile |
metabolite utilization
- @ref: 68377
- Chebi-ID: 27897
- metabolite: tryptophan
- utilization activity: -
- kind of utilization tested: energy source
metabolite production
- @ref: 68377
- Chebi-ID: 35581
- metabolite: indole
- production: no
metabolite tests
- @ref: 68377
- Chebi-ID: 35581
- metabolite: indole
- indole test: -
enzymes
| @ref | value | activity | ec |
|---|---|---|---|
| 3193 | catalase | + | 1.11.1.6 |
| 3193 | cytochrome-c oxidase | + | 1.9.3.1 |
| 68382 | alpha-fucosidase | - | 3.2.1.51 |
| 68382 | alpha-mannosidase | - | 3.2.1.24 |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 |
| 68382 | beta-glucosidase | - | 3.2.1.21 |
| 68382 | alpha-glucosidase | - | 3.2.1.20 |
| 68382 | beta-glucuronidase | - | 3.2.1.31 |
| 68382 | beta-galactosidase | - | 3.2.1.23 |
| 68382 | alpha-galactosidase | - | 3.2.1.22 |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | |
| 68382 | acid phosphatase | + | 3.1.3.2 |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 |
| 68382 | trypsin | - | 3.4.21.4 |
| 68382 | cystine arylamidase | - | 3.4.11.3 |
| 68382 | valine arylamidase | + | |
| 68382 | leucine arylamidase | + | 3.4.11.1 |
| 68382 | lipase (C 14) | - | |
| 68382 | esterase lipase (C 8) | + | |
| 68382 | esterase (C 4) | + | |
| 68382 | alkaline phosphatase | + | 3.1.3.1 |
| 68377 | tryptophan deaminase | - | 4.1.99.1 |
| 68377 | beta-galactosidase | - | 3.2.1.23 |
| 121898 | oxidase | - | |
| 121898 | catalase | - | 1.11.1.6 |
fatty acid profile
@ref fatty acid percentage ECL 45204 C15:0 0.6 15 45204 C16:0 12 16 45204 C17:0 0.9 17 45204 C18:0 3 18 45204 C20:0 1.9 20 45204 C14:0 ISO 2.4 13.618 45204 C14:0 ISO 3OH 0.8 15.117 45204 C14:1 ω5c 0.7 13.899 45204 C15:0 ANTEISO 9.4 14.711 45204 C15:1 ω6c 1.5 14.856 45204 C16:0 iso 23.4 15.626 45204 C16:1 ISO H 4.9 15.461 45204 C16:1 ω7c 29.6 15.819 45204 C17:0 anteiso 7.4 16.722 45204 C17:1 ω9c ANTEISO 1.4 16.525 - type of FA analysis: whole cell analysis
- method/protocol: CCUG
@ref fatty acid percentage ECL 45204 C14:0 1.5 14 45204 C15:0 1.1 15 45204 C16:0 9.8 16 45204 C17:0 0.7 17 45204 C18:0 2.3 18 45204 C19:0 0.5 19 45204 C20:0 2.2 20 45204 C14:0 ISO 5 13.618 45204 C14:0 ISO 3OH 1.3 15.117 45204 C14:1 ω5c 1.8 13.899 45204 C15:0 ANTEISO 9.2 14.711 45204 C15:1 ω6c 3.3 14.856 45204 C16:0 iso 17.8 15.626 45204 C16:1 ISO H 2.7 15.461 45204 C16:1 ω7c 35.3 15.819 45204 C17:0 anteiso 3.4 16.722 45204 C17:0 CYCLO 1.2 16.888 45204 Unidentified 0.4 13.244 45204 Unidentified 0.9 16.318 - type of FA analysis: whole cell analysis
- method/protocol: CCUG
@ref fatty acid percentage ECL 45204 C14:0 0.5 14 45204 C15:0 0.9 15 45204 C16:0 5.7 16 45204 C17:0 1 17 45204 C18:0 1.9 18 45204 C19:0 0.5 19 45204 C20:0 1.6 20 45204 C14:0 ISO 7 13.618 45204 C14:0 ISO 3OH 1 15.117 45204 C14:1 ω5c 1.3 13.899 45204 C15:0 ANTEISO 11 14.711 45204 C15:1 ω6c 3.8 14.856 45204 C16:0 iso 26.5 15.626 45204 C16:1 ISO H 4.1 15.461 45204 C16:1 ω7c 26.9 15.819 45204 C17:0 anteiso 4.2 16.722 45204 C17:0 CYCLO 1.6 16.888 45204 C17:1 ω9c ANTEISO 0.5 16.525 - type of FA analysis: whole cell analysis
- method/protocol: CCUG
API zym
| @ref | Control | Alkaline phosphatase | Esterase | Esterase Lipase | Lipase | Leucine arylamidase | Valine arylamidase | Cystine arylamidase | Trypsin | alpha- Chymotrypsin | Acid phosphatase | Naphthol-AS-BI-phosphohydrolase | alpha- Galactosidase | beta- Galactosidase | beta- Glucuronidase | alpha- Glucosidase | beta- Glucosidase | N-acetyl-beta- glucosaminidase | alpha- Mannosidase | alpha- Fucosidase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 121898 | - | + | + | + | - | + | + | - | - | - | + | + | - | - | - | - | - | - | - | - |
API NH
| @ref | PEN | GLU | FRU | MAL | SAC | ODC | URE | LIP | PAL | beta GAL | ProA | GGT | IND |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3193 | - | - | - | - | - | - | +/- | + | - | - | + | - | - |
| 3193 | + | + | + | + | +/- | - | - | + | - | - | + | - | - |
| 3193 | + | +/- | - | - | - | - | + | + | - | - | + | - | - |
| 3193 | - | + | +/- | - | - | - | - | + | + | - | - | + | - |
| 3193 | - | + | + | + | + | +/- | - | - | + | - | - | + | - |
| 3193 | - | - | - | - | - | - | - | +/- | + | - | - | + | - |
API biotype100
| @ref | GLU | FRU | GAL | TRE | MNE | SBE | MEL | SAC | RAF | MTE | MAL | LAC | LTE | MbGa | MaGa | CEL | GEN | MbGu | ESC | RIB | ARA | XYL | PLE | RHA | FUC | MLZ | DARL | LARL | XLT | DUL | TAG | GLY | INO | MAN | MTL | TUR | SOR | ADO | HBG | LYX | ERY | MDG | 3MDG | SAT | MUC | LTAT | DTAT | MTAT | DMLT | LMLT | CATE | TATE | TTE | CIT | GRT | GAT | 2KG | 5KG | TRY | NAG | GNT | PAC | PAT | pOBE | QAT | GTE | mOBE | BAT | PPAT | CMT | TGE | BET | PCE | ABT | HIN | LAT | CAP | CYT | HIS | SUC | FUM | GRE | GYT | AVT | ETN | TTN | GLN | ITA | 3OBU | APT | GTT | PRO | DALA | LALA | SER | MNT | PROP | TYR | 2KT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 121898 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Isolation, sampling and environmental information
isolation
| @ref | sample type | geographic location | country | origin.country | continent | latitude | longitude |
|---|---|---|---|---|---|---|---|
| 3193 | human lung tissue | Philadelphia | USA | USA | North America | 39.9526 | -75.1652 |
| 45204 | Human lung | Philadelphia | USA | USA | North America | ||
| 67770 | Human lung | ||||||
| 121898 | Human, Lung |
isolation source categories
| Cat1 | Cat2 | Cat3 |
|---|---|---|
| #Host | #Human | |
| #Host Body-Site | #Oral cavity and airways | #Lung |
| #Infection | #Patient |
taxonmaps
- @ref: 69479
- File name: preview.99_88.png
- url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_35;96_70;97_73;98_80;99_88&stattab=map
- Last taxonomy: Legionella pneumophila subclade
- 16S sequence: AB594755
- Sequence Identity:
- Total samples: 16955
- soil counts: 6537
- aquatic counts: 6971
- animal counts: 2429
- plant counts: 1018
Safety information
risk assessment
| @ref | biosafety level | biosafety level comment |
|---|---|---|
| 3193 | 2 | Risk group (German classification) |
| 121898 | 2 | Risk group (French classification) |
Sequence information
16S sequences
| @ref | description | accession | length | database | NCBI tax ID |
|---|---|---|---|---|---|
| 20218 | Legionella pneumophila strain ATCC33152 16S-23S rRNA intergenic region with tRNA-Ala-like sequence | AF000655 | 448 | ena | 446 |
| 20218 | Legionella pneumophila 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer and tRNA-Ala gene, complete sequence; and 23S ribosomal RNA gene, partial sequence | AY298787 | 3248 | ena | 446 |
| 20218 | L.pneumophila (strain Philadelphia-1) 16S rRNA, partial, segment 2 of 3 | M19444 | 137 | ena | 446 |
| 20218 | L.pneumophila (strain Philadelphia-1) 16S rRNA, partial, segment 1 of 3 | M19450 | 125 | ena | 446 |
| 20218 | L.pneumophila (strain Philadelphia-1) 16S rRNA, partial, segment 3 of 3 | M22266 | 141 | ena | 446 |
| 20218 | Legionella pneumophila 16S ribosomal RNA | M59157 | 1544 | ena | 446 |
| 67770 | Legionella pneumophila subsp. pneumophila gene for 16S rRNA, partial sequence, strain: JCM 7571 | AB594755 | 1466 | ena | 91891 |
| 67770 | Legionella pneumophila strain Philadelphia 1 16S ribosomal RNA gene, partial sequence | M36023 | 1474 | ena | 446 |
Genome sequences
| @ref | description | accession | assembly level | database | NCBI tax ID |
|---|---|---|---|---|---|
| 66792 | Legionella pneumophila Philadelphia-1 | GCA_001941585 | complete | ncbi | 446 |
| 66792 | Legionella pneumophila NCTC11192 | GCA_900452735 | contig | ncbi | 446 |
| 66792 | Legionella pneumophila ATCC 33152 | GCA_001582475 | scaffold | ncbi | 446 |
| 66792 | Legionella pneumophila subsp. pneumophila ATCC 33152 | GCA_000586375 | scaffold | ncbi | 91891 |
| 66792 | Legionella pneumophila subsp. pneumophila JCM 7571 | GCA_000614785 | contig | ncbi | 1236535 |
| 66792 | Legionella pneumophila strain ATCC 33152 | 446.161 | wgs | patric | 446 |
| 66792 | Legionella pneumophila strain FDAARGOS_779 | 446.946 | complete | patric | 446 |
| 66792 | Legionella pneumophila strain NCTC11192 | 446.727 | wgs | patric | 446 |
| 66792 | Legionella pneumophila subsp. pneumophila JCM 7571 | 1236535.3 | wgs | patric | 1236535 |
| 66792 | Legionella pneumophila subsp. pneumophila strain ATCC 33152 | 91891.34 | wgs | patric | 91891 |
| 66792 | Legionella pneumophila pneumophila JCM 7571 | 2585427928 | draft | img | 1236535 |
| 66792 | Legionella pneumophila pneumophila ATCC 33152 | 2660238207 | draft | img | 91891 |
| 67770 | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 | GCA_000008485 | complete | ncbi | 272624 |
GC content
- @ref: 3193
- GC-content: 39.0
- method: thermal denaturation, midpoint method (Tm)
Genome-based predictions
predictions
| trait | prediction | confidence | training_data |
|---|---|---|---|
| flagellated | no | 68.906 | no |
| gram-positive | no | 98.641 | no |
| anaerobic | no | 98.672 | yes |
| halophile | no | 88.876 | no |
| spore-forming | no | 94.592 | no |
| glucose-util | yes | 69.005 | no |
| aerobic | no | 91.407 | yes |
| thermophile | no | 98.315 | yes |
| motile | yes | 80.696 | no |
| glucose-ferment | no | 85.308 | no |
External links
@ref: 3193
culture collection no.: DSM 7513, ATCC 33152, WDCM 00107, CCUG 9568, NCTC 11192, JCM 7571, BCRC 17854, CECT 7109, CIP 103854, CCM 7799, Philadelphia 1
straininfo link
- @ref: 76185
- straininfo: 40359
literature
| topic | Pubmed-ID | title | authors | journal | DOI | year | mesh | topic2 |
|---|---|---|---|---|---|---|---|---|
| Phylogeny | 1379959 | Isolation and characterization of a lipopolysaccharide mutant of Legionella pneumophila. | Mintz CS, Zou CH | FEMS Microbiol Lett | 10.1016/0378-1097(92)90470-9 | 1992 | Blood Bactericidal Activity, Cell Line, Epitopes/genetics/immunology, Humans, Legionella pneumophila/*genetics/growth & development/immunology/isolation & purification, Lipopolysaccharides/*genetics/immunology/isolation & purification, Monocytes/cytology, Mutation, Serotyping | Pathogenicity |
| Phylogeny | 1987055 | Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila multiplication in vitro. | Yoshida S, Goto Y, Mizuguchi Y, Nomoto K, Skamene E | Infect Immun | 10.1128/iai.59.1.428-432.1991 | 1991 | Alleles, Animals, Female, Immunity, Innate/genetics, In Vitro Techniques, Legionella/*growth & development, Legionellosis/immunology, Macrophages/*immunology/microbiology, Male, Mice, Mice, Inbred Strains, Species Specificity | |
| Pathogenicity | 2138651 | The HL-60 model for the interaction of human macrophages with the Legionnaires' disease bacterium. | Marra A, Horwitz MA, Shuman HA | J Immunol | 1990 | Bacterial Adhesion, Cell Adhesion, Complement C3/metabolism, Complement System Proteins/physiology, Humans, In Vitro Techniques, Iron/physiology, Legionella/growth & development/*immunology/pathogenicity, Macrophages/immunology/*microbiology, Phagocytosis, Phagosomes/ultrastructure, Receptors, Complement/physiology, Receptors, Complement 3b, Ribosomes/ultrastructure, Tumor Cells, Cultured | Metabolism | |
| Enzymology | 2381440 | [Specific DNA probe for detecting Legionella pneumophila]. | Nagaev IG, Zigangirova NA, Gintsburg AL, Tartakovskii IS, Prozorovskii SV | Mol Gen Mikrobiol Virusol | 1990 | Cytotoxins/biosynthesis/genetics, *DNA Probes, DNA, Bacterial/*genetics, Deoxyribonuclease EcoRI, Electrophoresis, Polyacrylamide Gel, Legionella/genetics/*isolation & purification, Legionnaires' Disease/*diagnosis, *Nucleic Acid Hybridization, Restriction Mapping | Phylogeny | |
| Phylogeny | 2703472 | Isolation of a Legionella pneumophila restriction mutant with increased ability to act as a recipient in heterospecific matings. | Marra A, Shuman HA | J Bacteriol | 10.1128/jb.171.4.2238-2240.1989 | 1989 | Conjugation, Genetic, DNA Restriction-Modification Enzymes/*genetics, Legionella/*genetics, Mutation, Plasmids | Enzymology |
| Metabolism | 3308708 | Fate of Legionella pneumophila Philadelphia-1 strain in resident, elicited, activated, and immune peritoneal macrophages of guinea pigs. | Yoshida S, Mizuguchi Y, Nikaido Y, Mitsuyama M, Nomoto K | Infect Immun | 10.1128/iai.55.10.2477-2482.1987 | 1987 | Animals, Cells, Cultured, Female, Glucose/metabolism, Guinea Pigs, Immunization, Legionella/*growth & development/immunology, *Macrophage Activation, Macrophages/immunology/*microbiology, Mycobacterium bovis/immunology, Phagocytosis, Propionibacterium acnes/immunology | |
| Enzymology | 3309831 | [Doxycycline treatment of experimental legionellosis in guinea pigs infected by aerosol]. | Nowicki M, Paucod JC, Bornstein N, Meugnier H, Freney J, Isoard P, Fleurette J | Pathol Biol (Paris) | 1987 | Aerosols, Animals, Doxycycline/blood/pharmacokinetics/*therapeutic use, Guinea Pigs, Legionnaires' Disease/*drug therapy/microbiology, Lung/metabolism, Male | Metabolism | |
| Pathogenicity | 3372016 | Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes. | Mintz CS, Chen JX, Shuman HA | Infect Immun | 10.1128/iai.56.6.1449-1455.1988 | 1988 | Culture Media, Humans, Kinetics, Legionella/genetics/*growth & development/isolation & purification, Legionnaires' Disease/microbiology, Leukocytes, Mononuclear/drug effects/*microbiology/physiology, *Mutation, Thymidine/deficiency/pharmacology, Tryptophan | Enzymology |
| Pathogenicity | 3435101 | Effect of quinolones and other antimicrobial agents on cell-associated Legionella pneumophila. | Havlichek D, Saravolatz L, Pohlod D | Antimicrob Agents Chemother | 10.1128/AAC.31.10.1529 | 1987 | Anti-Bacterial Agents/*pharmacology, Humans, In Vitro Techniques, Legionella/*drug effects, Microbial Sensitivity Tests, Quinolines/*pharmacology | |
| Enzymology | 3663768 | [Extracellular metalloproteinase from Legionella pneumophila]. | Gul'nik SV, Lavrenova GI, Stepanov VM | Biokhimiia | 1987 | Amino Acids/analysis, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Electrophoresis, Disc, Hydrogen-Ion Concentration, Legionella/*enzymology, Metalloendopeptidases/*isolation & purification, Peptides/analysis | Phylogeny | |
| Pathogenicity | 3685714 | In vitro effects of monobactams on Legionella pneumophila. | Yoshida S, Mizuguchi Y, Nikaido Y | J UOEH | 10.7888/juoeh.9.299 | 1987 | Animals, Anti-Bacterial Agents/*pharmacology, Aztreonam/*pharmacology, Guinea Pigs, Legionella/*drug effects/physiology, Macrophages/microbiology, Microbial Sensitivity Tests | |
| 3719461 | Multiplication of Legionella pneumophila Philadelphia-1 in cultured peritoneal macrophages and its correlation to susceptibility of animals. | Yoshida S, Mizuguchi Y | Can J Microbiol | 10.1139/m86-083 | 1986 | Animals, Bacterial Infections/*immunology, Cells, Cultured, Cricetinae, Disease Susceptibility, Female, Guinea Pigs, Immunity, Innate, Legionella/*growth & development/pathogenicity, Macrophages/*microbiology, Mesocricetus, Mice, Mice, Inbred Strains, Rats, Rats, Inbred Strains | ||
| Phylogeny | 3980693 | DNA probe specific for Legionella pneumophila. | Grimont PA, Grimont F, Desplaces N, Tchen P | J Clin Microbiol | 10.1128/jcm.21.3.431-437.1985 | 1985 | Base Sequence, DNA, Bacterial/*analysis, Legionella/*genetics, Nucleic Acid Hybridization | |
| 4020112 | A comparison of virulence of two strains of Legionella pneumophila based on experimental aerosol infection of guinea-pigs. | Jepras RI, Fitzgeorge RB, Baskerville A | J Hyg (Lond) | 10.1017/s0022172400062252 | 1985 | Aerosols, Animals, Female, Guinea Pigs, Kidney/microbiology, Legionella/growth & development/*pathogenicity, Legionnaires' Disease/*microbiology/pathology, Liver/microbiology, Lung/*microbiology/pathology, Macrophages/immunology/microbiology, Neutrophils/immunology/microbiology, Phagocytosis, Sepsis, Spleen/microbiology/pathology, Time Factors, Virulence | ||
| Pathogenicity | 4066557 | Effects of tetracyclines on experimental Legionella pneumophila infection in guinea-pigs. | Yoshida S, Mizuguchi Y, Ohta H, Ogawa M | J Antimicrob Chemother | 10.1093/jac/16.2.199 | 1985 | Animals, Doxycycline/pharmacology/therapeutic use, Guinea Pigs, Legionella/*drug effects/growth & development, Legionnaires' Disease/*drug therapy/microbiology, Macrophages/microbiology, Male, Minocycline/pharmacology/therapeutic use, Tetracycline/pharmacology/therapeutic use, Tetracyclines/pharmacology/*therapeutic use | |
| 6401778 | Aerosol infection of animals with strains of Legionella pneumophila of different virulence: comparison with intraperitoneal and intranasal routes of infection. | Fitzgeorge RB, Baskerville A, Broster M, Hambleton P, Dennis PJ | J Hyg (Lond) | 10.1017/s0022172400063877 | 1983 | Aerosols, Animals, Antibodies, Bacterial/analysis, Callitrichinae, *Disease Models, Animal, Female, Guinea Pigs, Legionella/immunology/pathogenicity/*physiology, Legionnaires' Disease/*microbiology/pathology, Lung/microbiology/pathology, Macaca fascicularis, Macaca mulatta, Male, Mice, Nose, Peritoneum | ||
| Pathogenicity | 6736922 | Antibiotic susceptibility of Legionella pneumophia Philadelphia-1 in cultured guinea-pig peritoneal macrophages. | Yoshida S, Mizuguchi Y | J Gen Microbiol | 10.1099/00221287-130-4-901 | 1984 | Animals, Anti-Bacterial Agents/*pharmacology, Dose-Response Relationship, Drug, Guinea Pigs, Legionella/*drug effects/growth & development, Macrophages/microbiology, Microbial Sensitivity Tests, Peritoneum/microbiology | |
| 7824817 | Intracellular multiplication of Legionella pneumophila in Tetrahymena thermophila. | Kikuhara H, Ogawa M, Miyamoto H, Nikaido Y, Yoshida S | J UOEH | 10.7888/juoeh.16.263 | 1994 | Animals, Legionella pneumophila/*growth & development/ultrastructure, Microscopy, Electron, Temperature, Tetrahymena thermophila/*microbiology/ultrastructure | ||
| Enzymology | 8007818 | Protein profiles of Legionella pneumophila Philadelphia-1 grown in macrophages and characterization of a gene encoding a novel 24 kDa Legionella protein. | Miyamoto H, Yoshida S, Taniguchi H, Qin MH, Fujio H, Mizuguchi Y | Microb Pathog | 10.1006/mpat.1993.1095 | 1993 | Amino Acid Sequence, Animals, Bacterial Proteins/*genetics, Base Sequence, Cells, Cultured, Cloning, Molecular, Cricetinae, DNA, Bacterial, Electrophoresis, Polyacrylamide Gel, Genes, Bacterial, Guinea Pigs, Legionella pneumophila/*genetics/growth & development, Macrophages/cytology/*microbiology, Mesocricetus, Mice, Molecular Sequence Data, Restriction Mapping | Genetics |
| Pathogenicity | 8270798 | [Study of Legionella pneumophila detection by two step polymerase chain reaction]. | Koide M, Saito A, Higa F, Yamashiro Y, Ishimine T, Futenma M, Inadome J, Kawakami K, Kusano N | Kansenshogaku Zasshi | 10.11150/kansenshogakuzasshi1970.67.1062 | 1993 | Base Sequence, Humans, Legionella pneumophila/*isolation & purification, Legionnaires' Disease/microbiology, Molecular Sequence Data, Polymerase Chain Reaction/methods, Sensitivity and Specificity | Genetics |
| Pathogenicity | 8536723 | Enzyme immunoassay for detection of antibodies against isolated flagella of Legionella pneumophila. | Neumeister B, Susa M, Nowak B, Straube E, Ruckdeschel G, Hacker J, Marre R | Eur J Clin Microbiol Infect Dis | 10.1007/BF01690990 | 1995 | Antibodies, Bacterial/*blood, Flagella/*immunology, Fluorescent Antibody Technique, Indirect, Humans, Immunoenzyme Techniques, Legionella pneumophila/*immunology | Enzymology |
| Enzymology | 8804974 | Increased plasma adenosine deaminase activity in the early phase of Legionella pneumophila infection in guinea pigs. | Nikaido Y, Nagata N, Kido M, Yoshida S | FEMS Immunol Med Microbiol | 10.1111/j.1574-695X.1996.tb00265.x | 1996 | Adenosine Deaminase/*biosynthesis, Animals, Bacterial Infections/blood/enzymology, Female, Guinea Pigs, Haemophilus influenzae, Klebsiella pneumoniae, *Legionella pneumophila, Legionnaires' Disease/blood/diagnosis/*enzymology, Staphylococcus aureus, Streptococcus pneumoniae | |
| Pathogenicity | 10518043 | Grouping of 20 reference strains of Legionella species by the growth ability within mouse and guinea pig macrophages. | Izu K, Yoshida S, Miyamoto H, Chang B, Ogawa M, Yamamoto H, Goto Y, Taniguchi H | FEMS Immunol Med Microbiol | 10.1111/j.1574-695X.1999.tb01372.x | 1999 | Animals, Colony Count, Microbial, Female, Guinea Pigs, Humans, Legionella/classification/*growth & development, Macrophages, Peritoneal/*microbiology, Male, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Time Factors | Phylogeny |
| Metabolism | 10633110 | Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila. | Liles MR, Scheel TA, Cianciotto NP | J Bacteriol | 10.1128/JB.182.3.749-757.2000 | 2000 | Bacterial Proteins/*biosynthesis, Endopeptidases/metabolism, Hot Temperature, Hydroxybenzoates, Iron/metabolism, Iron Chelating Agents/*metabolism, Legionella pneumophila/*metabolism | Stress |
| Stress | 10677839 | Disinfectant effects of hot water, ultraviolet light, silver ions and chlorine on strains of Legionella and nontuberculous mycobacteria. | Miyamoto M, Yamaguchi Y, Sasatsu M | Microbios | 2000 | Chlorine/pharmacology, Disinfectants/pharmacology, Disinfection/*methods, Hot Temperature, Legionella pneumophila/drug effects/*growth & development, Mycobacterium avium Complex/drug effects/*growth & development, Silver/pharmacology, Ultraviolet Rays, Water | Pathogenicity | |
| 11529560 | Fate of Legionella pneumophila in macrophages of C57BL/6 chronic granulomatous disease mice. | Saito M, Kajiwara H, Miyamoto H, Yoshida S | Microbiol Immunol | 10.1111/j.1348-0421.2001.tb02655.x | 2001 | Animals, Female, Granulomatous Disease, Chronic/immunology/*microbiology, Legionella pneumophila/*growth & development/pathogenicity, Legionnaires' Disease/immunology/*microbiology, Macrophages, Peritoneal/*microbiology, Male, Mice, Mice, Inbred C57BL, Phagocytosis/immunology | ||
| Pathogenicity | 11529563 | Morphological variety of intracellular microcolonies of Legionella species in Vero cells. | Ogawa M, Takade A, Miyamoto H, Taniguchi H, Yoshida S | Microbiol Immunol | 10.1111/j.1348-0421.2001.tb02658.x | 2001 | Animals, Chlorocebus aethiops, Humans, Legionella/*classification/pathogenicity/physiology/*ultrastructure, Microscopy, Electron, Vero Cells | Phylogeny |
| Pathogenicity | 12003984 | Intracellular activity of ABT-773 and other antimicrobial agents against Legionella pneumophila. | Jung R, Danziger LH, Pendland SL | J Antimicrob Chemother | 10.1093/jac/dkf017 | 2002 | Anti-Bacterial Agents/*pharmacology, Azithromycin/pharmacology, Ciprofloxacin/pharmacology, Erythromycin/*analogs & derivatives/*pharmacology, HL-60 Cells, Humans, *Ketolides, Legionella pneumophila/*drug effects, Microbial Sensitivity Tests | |
| Genetics | 12205057 | Sequence and genome context analysis of a new molecular class D beta-lactamase gene from Legionella pneumophila. | Avison MB, Simm AM | J Antimicrob Chemother | 10.1093/jac/dkf135 | 2002 | Amino Acid Sequence, Base Sequence, Chromosomes, Bacterial/genetics, Cloning, Molecular, Genes, Bacterial/*genetics, *Genome, Bacterial, Legionella pneumophila/enzymology/*genetics, Molecular Sequence Data, Penicillinase/*genetics, Phylogeny, Polymerase Chain Reaction, Sequence Alignment, beta-Lactamases/genetics | Enzymology |
| Genetics | 12734211 | Characterization of a tandem repeat polymorphism in Legionella pneumophila and its use for genotyping. | Pourcel C, Vidgop Y, Ramisse F, Vergnaud G, Tram C | J Clin Microbiol | 10.1128/JCM.41.5.1819-1826.2003 | 2003 | Amino Acid Sequence, Bacterial Typing Techniques, Base Sequence, DNA, Bacterial/genetics/isolation & purification, Electrophoresis, Gel, Pulsed-Field, Environmental Microbiology, Genome, Bacterial, Genotype, Humans, Legionella pneumophila/classification/*genetics/isolation & purification, *Minisatellite Repeats, Molecular Sequence Data, *Polymorphism, Genetic, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Serotyping | Enzymology |
| Pathogenicity | 12867476 | A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila. | Brassinga AK, Hiltz MF, Sisson GR, Morash MG, Hill N, Garduno E, Edelstein PH, Garduno RA, Hoffman PS | J Bacteriol | 10.1128/JB.185.15.4630-4637.2003 | 2003 | Amino Acid Sequence, Bacterial Proteins/chemistry/*genetics, Chromosomes, Bacterial/*genetics, Cluster Analysis, Humans, Legionella pneumophila/*genetics/*pathogenicity, Molecular Sequence Data, Multigene Family, Virulence | Genetics |
| Pathogenicity | 14594847 | Virulence conversion of Legionella pneumophila by conjugal transfer of chromosomal DNA. | Miyamoto H, Yoshida S, Taniguchi H, Shuman HA | J Bacteriol | 10.1128/JB.185.22.6712-6718.2003 | 2003 | Acanthamoeba/microbiology, Animals, Bacterial Proteins/*genetics/metabolism, Chromosomes, Bacterial, *Conjugation, Genetic, *Gene Transfer, Horizontal, Guinea Pigs, Humans, Legionella pneumophila/genetics/growth & development/*pathogenicity, Legionnaires' Disease/microbiology, Macrophages, Peritoneal/microbiology, Virulence/genetics | Metabolism |
| Pathogenicity | 15126465 | Expression of magA in Legionella pneumophila Philadelphia-1 is developmentally regulated and a marker of formation of mature intracellular forms. | Hiltz MF, Sisson GR, Brassinga AK, Garduno E, Garduno RA, Hoffman PS | J Bacteriol | 10.1128/JB.186.10.3038-3045.2004 | 2004 | Amino Acid Sequence, Bacterial Proteins/chemistry/*genetics/physiology, Base Sequence, Biomarkers, Chromosome Mapping, *Gene Expression Regulation, Bacterial, HeLa Cells, Humans, Legionella pneumophila/*genetics/growth & development, Molecular Sequence Data, Promoter Regions, Genetic | Genetics |
| Enzymology | 15636757 | First proteomic analysis of Legionella pneumophila based on its developing genome sequence. | Lebeau I, Lammertyn E, De Buck E, Maes L, Geukens N, Van Mellaert L, Arckens L, Anne J, Clerens S | Res Microbiol | 10.1016/j.resmic.2004.08.010 | 2005 | Amino Acid Sequence, Bacterial Proteins/analysis/isolation & purification, Electrophoresis, Gel, Two-Dimensional, Legionella pneumophila/genetics/*physiology, Molecular Sequence Data, *Proteome/analysis/isolation & purification, *Proteomics, Sequence Analysis, Protein, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Genetics |
| Pathogenicity | 15883032 | Legionella pneumophila Philadelphia-1 tatB and tatC affect intracellular replication and biofilm formation. | De Buck E, Maes L, Meyen E, Van Mellaert L, Geukens N, Anne J, Lammertyn E | Biochem Biophys Res Commun | 10.1016/j.bbrc.2005.04.060 | 2005 | Amino Acid Sequence, Bacterial Proteins/chemistry/*metabolism, Biofilms, Humans, Legionella pneumophila/*enzymology/growth & development, Molecular Sequence Data, Substrate Specificity, U937 Cells | Genetics |
| Metabolism | 16267296 | Evidence for acquisition of Legionella type IV secretion substrates via interdomain horizontal gene transfer. | de Felipe KS, Pampou S, Jovanovic OS, Pericone CD, Ye SF, Kalachikov S, Shuman HA | J Bacteriol | 10.1128/JB.187.22.7716-7726.2005 | 2005 | Amino Acid Motifs/genetics, Bacterial Proteins/*genetics/metabolism, Computational Biology, *Gene Transfer, Horizontal, Genes, Bacterial, Genome, Bacterial, Legionella pneumophila/*genetics/metabolism, Open Reading Frames/genetics, *Protein Transport | Genetics |
| Pathogenicity | 16849718 | Distribution of 19 major virulence genes in Legionella pneumophila serogroup 1 isolates from patients and water in Queensland, Australia. | Huang B, Yuan Z, Heron BA, Gray BR, Eglezos S, Bates JR, Savill J | J Med Microbiol | 10.1099/jmm.0.46310-0 | 2006 | Australia, Bacterial Proteins/genetics, Bacterial Toxins/genetics, Genetic Markers/genetics, Genomic Islands/genetics, Humans, Legionella pneumophila/*genetics/pathogenicity, Legionnaires' Disease/epidemiology/*microbiology, Polymerase Chain Reaction, Virulence/genetics, *Water Microbiology | |
| 16935249 | Influence of temperature on growth of Legionella pneumophila biofilm determined by precise temperature gradient incubator. | Konishi T, Yamashiro T, Koide M, Nishizono A | J Biosci Bioeng | 10.1263/jbb.101.478 | 2006 | Adaptation, Physiological/physiology, Biofilms/*growth & development, Bioreactors/*microbiology, Cell Culture Techniques/instrumentation/*methods, Cell Proliferation, Legionella pneumophila/*cytology/*physiology, Temperature | ||
| Metabolism | 17188684 | The twin-arginine translocation pathway is necessary for correct membrane insertion of the Rieske Fe/S protein in Legionella pneumophila. | De Buck E, Vranckx L, Meyen E, Maes L, Vandersmissen L, Anne J, Lammertyn E | FEBS Lett | 10.1016/j.febslet.2006.12.022 | 2006 | Arginine/metabolism, Bacterial Proteins/analysis/*metabolism, Cell Membrane/chemistry/*metabolism, Electron Transport Complex III/analysis/*metabolism, Iron-Sulfur Proteins/analysis/*metabolism, Legionella pneumophila/genetics/*metabolism, Membrane Transport Proteins/analysis/genetics/*metabolism, Mutation, Protein Transport | |
| Metabolism | 17723319 | Differential 2-D protein gel electrophoresis analysis of Legionella pneumophila wild type and Tat secretion mutants. | De Buck E, Hoper D, Lammertyn E, Hecker M, Anne J | Int J Med Microbiol | 10.1016/j.ijmm.2007.06.003 | 2007 | 3',5'-Cyclic-AMP Phosphodiesterases/metabolism, Antibodies, Bacterial/immunology, Antibodies, Monoclonal/immunology, Bacterial Proteins/genetics/*metabolism, Carrier Proteins/biosynthesis/*genetics, Cell Line, Colony Count, Microbial, *Electrophoresis, Gel, Two-Dimensional, Flagellin/metabolism, Humans, Legionella pneumophila/*chemistry/genetics/pathogenicity, Monocytes/microbiology, Proteome/*metabolism, Virulence/genetics | Enzymology |
| Metabolism | 18281405 | Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila. | Belyi Y, Tabakova I, Stahl M, Aktories K | J Bacteriol | 10.1128/JB.01798-07 | 2008 | Acanthamoeba castellanii/microbiology, Amino Acid Sequence, Animals, Bacterial Proteins/genetics/*metabolism, Cattle, Cell Line, Cell Survival, DNA, Bacterial/chemistry/genetics, Gene Expression Profiling, Gene Expression Regulation, Bacterial/physiology, Glucosyltransferases/genetics/*metabolism, Glycosylation, Legionella pneumophila/*enzymology/genetics, Molecular Sequence Data, Peptide Elongation Factor 1/*antagonists & inhibitors/metabolism, Protein Biosynthesis, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Virulence Factors/genetics/*metabolism | Genetics |
| Phylogeny | 18464535 | [Molecular genetic typing of Legionella pneumophila serogroup 1 isolated in town Verkhnyaya Pyshma using international standards]. | Voronina OL, Lunin VG | Zh Mikrobiol Epidemiol Immunobiol | 2008 | Alleles, Bacterial Proteins/genetics, Bacterial Typing Techniques/*standards, Clinical Laboratory Techniques/*standards, *Genes, Bacterial, Humans, Legionella pneumophila/*classification/genetics, Legionnaires' Disease/epidemiology/*microbiology, Porins/genetics, Reference Standards, Russia/epidemiology, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid | Pathogenicity | |
| Pathogenicity | 19398893 | Autophagy induced by 2-deoxy-D-glucose suppresses intracellular multiplication of Legionella pneumophila in A/J mouse macrophages. | Matsuda F, Fujii J, Yoshida S | Autophagy | 10.4161/auto.5.4.7760 | 2009 | Animals, Apoptosis/drug effects/genetics, Autophagy/*drug effects, Caspase Inhibitors, Caspases/genetics/metabolism, Caspases, Initiator, Deoxyglucose/*pharmacology, Down-Regulation/drug effects, Endoplasmic Reticulum/drug effects/pathology/ultrastructure, Enzyme Inhibitors/pharmacology, Gene Expression Regulation, Enzymologic/drug effects, Immunoblotting, Intracellular Space/*drug effects/*microbiology, Legionella pneumophila/drug effects/*growth & development/ultrastructure, Macrophages, Peritoneal/*cytology/enzymology/*microbiology/ultrastructure, Mice, Oligonucleotide Array Sequence Analysis, Phagosomes/drug effects/ultrastructure, RNA, Messenger/genetics/metabolism, Reproducibility of Results, Up-Regulation/drug effects | Metabolism |
| Phylogeny | 20000116 | [Comparative study of the biological properties of various nutrient media used for the isolation of Legionella pneumophila]. | Shelokhovich AI, Kharabadzhakhian GD, Karbyshev GL, Terent'ev AN, Savel'eva IK, Savel'eva EP, Sokirkina OG | Klin Lab Diagn | 2009 | Bacteriological Techniques, *Culture Media, Legionella pneumophila/*isolation & purification | Cultivation | |
| Phylogeny | 20008105 | Legionella dresdenensis sp. nov., isolated from river water. | Luck PC, Jacobs E, Roske I, Schroter-Bobsin U, Dumke R, Gronow S | Int J Syst Evol Microbiol | 10.1099/ijs.0.017863-0 | 2009 | Bacterial Proteins/genetics, Cysteine/metabolism, DNA, Bacterial/genetics, Fresh Water/analysis/*microbiology, Legionella/*classification/genetics/*isolation & purification/metabolism, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, 16S/genetics | Metabolism |
| Pathogenicity | 20049525 | In vitro activity of antimicrobial agents against Legionella isolated from environmental water systems: first results from Turkey. | Erdogan H, Can F, Demirbilek M, Timurkaynak F, Arslan H | Environ Monit Assess | 10.1007/s10661-009-1293-y | 2010 | Anti-Infective Agents/*pharmacology, Humans, Legionella pneumophila/*drug effects, Legionnaires' Disease/microbiology, Microbial Sensitivity Tests, Turkey, *Water Microbiology, *Water Supply | |
| Genetics | 20833813 | Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins. | Schroeder GN, Petty NK, Mousnier A, Harding CR, Vogrin AJ, Wee B, Fry NK, Harrison TG, Newton HJ, Thomson NR, Beatson SA, Dougan G, Hartland EL, Frankel G | J Bacteriol | 10.1128/JB.00778-10 | 2010 | Conserved Sequence, DNA, Bacterial/*chemistry/genetics, Environmental Microbiology, *Genome, Bacterial, Humans, Legionella pneumophila/*genetics/isolation & purification/metabolism/pathogenicity, Legionnaires' Disease/microbiology, Membrane Transport Proteins/*genetics/metabolism, Molecular Sequence Data, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Virulence Factors/*genetics/metabolism | Metabolism |
| Enzymology | 21046330 | Genomic diversity of Legionella pneumophila serogroup 1 from environmental water sources and clinical specimens using pulsed-field gel electrophoresis (PFGE) from 1985 to 2007, Korea. | Lee HK, Kang YH, Yu JY | J Microbiol | 10.1007/s12275-010-0031-z | 2010 | *Bacterial Typing Techniques, Cluster Analysis, DNA Fingerprinting, DNA, Bacterial/*genetics, *Electrophoresis, Gel, Pulsed-Field, Genotype, Geography, Humans, Korea, Legionella pneumophila/*classification/*genetics/isolation & purification, Legionnaires' Disease/*microbiology, Molecular Epidemiology, *Water Microbiology | Genetics |
| Pathogenicity | 21623847 | Differential growth of Legionella pneumophila strains within a range of amoebae at various temperatures associated with in-premise plumbing. | Buse HY, Ashbolt NJ | Lett Appl Microbiol | 10.1111/j.1472-765X.2011.03094.x | 2011 | Acanthamoeba/microbiology, Amoeba/*microbiology, Drinking Water/microbiology/parasitology, Hartmannella/microbiology, Humans, Legionella pneumophila/*growth & development, *Sanitary Engineering, Temperature, Water Microbiology | |
| Genetics | 21956982 | The N-acylneuraminate cytidyltransferase gene, neuA, is heterogenous in Legionella pneumophila strains but can be used as a marker for epidemiological typing in the consensus sequence-based typing scheme. | Farhat C, Mentasti M, Jacobs E, Fry NK, Luck C | J Clin Microbiol | 10.1128/JCM.00687-11 | 2011 | Acetyltransferases/*genetics, Cluster Analysis, Consensus Sequence, DNA Primers/genetics, DNA, Bacterial/chemistry/genetics, *Genetic Variation, Genotype, Legionella pneumophila/*classification/*enzymology/genetics, Molecular Epidemiology/methods, Molecular Sequence Data, Molecular Typing/*methods, Sequence Analysis, DNA | Transcriptome |
| Phylogeny | 22377993 | Evaluation of DNA isolation procedures for detecting and quantifying environmental Legionella by real-time quantitative PCR. | Chen NT, Chang CW, Wu JD | Water Sci Technol | 10.2166/wst.2012.001 | 2012 | DNA, Bacterial/genetics/*isolation & purification, Legionella/*genetics/*isolation & purification, Limit of Detection, Real-Time Polymerase Chain Reaction/*methods, *Water Microbiology | Enzymology |
| Genetics | 22466030 | Liver cirrhosis as a predisposing condition for Legionnaires' disease: a report of four laboratory-confirmed cases from China. | Qin T, Xia J, Ren H, Zhou H, Tang B, Shao Z | J Med Microbiol | 10.1099/jmm.0.040170-0 | 2012 | Adult, Anti-Bacterial Agents/administration & dosage, Bacteriological Techniques, China, Fluorescent Antibody Technique, Direct, Genotype, Humans, Legionella pneumophila/classification/genetics/*isolation & purification, Legionnaires' Disease/*diagnosis/drug therapy, Liver Cirrhosis/*complications, Male, Molecular Typing, Real-Time Polymerase Chain Reaction, Treatment Outcome | Pathogenicity |
| Pathogenicity | 22843284 | Detection of Legionella pneumophila on clinical samples and susceptibility assessment by flow cytometry. | Faria-Ramos I, Costa-de-Oliveira S, Barbosa J, Cardoso A, Santos-Antunes J, Rodrigues AG, Pina-Vaz C | Eur J Clin Microbiol Infect Dis | 10.1007/s10096-012-1702-y | 2012 | Anti-Bacterial Agents/*pharmacology, Antibodies, Bacterial, Antibodies, Monoclonal, Cross Reactions, Flow Cytometry/*methods, Fluorescence, Fluorescent Dyes/metabolism, Humans, Legionella pneumophila/*drug effects/*isolation & purification, Legionnaires' Disease/*diagnosis/microbiology, Microbial Sensitivity Tests/methods, Sensitivity and Specificity, Staining and Labeling/methods | Metabolism |
| Phenotype | 22966048 | Virulence phenotypes of Legionella pneumophila associated with noncoding RNA lpr0035. | Jayakumar D, Early JV, Steinman HM | Infect Immun | 10.1128/IAI.00598-12 | 2012 | Acanthamoeba castellanii/microbiology, Animals, Bacterial Proteins/*genetics, Base Sequence, Cell Line, Legionella pneumophila/genetics/*pathogenicity, Macrophages, Peritoneal/cytology/microbiology, Mice, Molecular Sequence Data, Phenotype, RNA, Untranslated/*genetics, Sequence Deletion, Virulence/*genetics | Genetics |
| Pathogenicity | 23135482 | Protozoa and human macrophages infection by Legionella pneumophila environmental strains belonging to different serogroups. | Messi P, Bargellini A, Anacarso I, Marchesi I, de Niederhausern S, Bondi M | Arch Microbiol | 10.1007/s00203-012-0851-9 | 2012 | Acanthamoeba/*microbiology, Drinking Water/microbiology, Host Specificity, Humans, Legionella pneumophila/*classification/growth & development/*pathogenicity, Macrophages/*microbiology, U937 Cells, Virulence | Phylogeny |
| Pathogenicity | 23231042 | Assessment of cytokine release after in vitro stimulation of whole blood with legionella pneumophila in immunocompromised patients. | Sikora A, Koziol-Montewka M, Ksiazek A, Wojtowicz M, Paluch-Oles J, Magrys A, Grzebalska A, Bednarek-Skublewska A, Stec A, Rudzki S, Furmaga J, Matuszewska R, Krogulska B | Immunol Invest | 10.3109/08820139.2012.719562 | 2013 | Adult, Aged, Aged, 80 and over, Blood Cells/*immunology, Cells, Cultured, Female, Humans, Immunization/*methods, Immunocompromised Host/*immunology, Interferon-gamma/*metabolism, Kidney Transplantation, Legionella pneumophila/*immunology, Male, Middle Aged, *Renal Dialysis, Tumor Necrosis Factor-alpha/*metabolism, Young Adult | Metabolism |
| Phylogeny | 23717549 | Phylogenetic reconstruction of the Legionella pneumophila Philadelphia-1 laboratory strains through comparative genomics. | Rao C, Benhabib H, Ensminger AW | PLoS One | 10.1371/journal.pone.0064129 | 2013 | *Genome, Bacterial, Legionella pneumophila/*classification/genetics, Mutation, *Phylogeny, Polymorphism, Genetic | Genetics |
| Metabolism | 23729650 | Implication of the VirD4 coupling protein of the Lvh type 4 secretion system in virulence phenotypes of Legionella pneumophila. | Bandyopadhyay P, Lang EA, Rasaputra KS, Steinman HM | J Bacteriol | 10.1128/JB.00430-13 | 2013 | Animals, Bacterial Proteins/*metabolism, *Bacterial Secretion Systems, Cell Line, Gene Deletion, Genetic Complementation Test, Legionella pneumophila/genetics/metabolism/*pathogenicity, Macrophages/microbiology, Mice, Phagosomes/microbiology, Virulence, Virulence Factors/genetics/*metabolism | Phenotype |
| Metabolism | 23764733 | Hartmannella vermiformis inhibition of Legionella pneumophila cultivability. | Buse HY, Donohue MJ, Ashbolt NJ | Microb Ecol | 10.1007/s00248-013-0250-z | 2013 | Acanthamoeba/chemistry/metabolism/microbiology, Anti-Bacterial Agents/chemistry/isolation & purification/metabolism/*pharmacology, Down-Regulation/*drug effects, Hartmannella/*chemistry/metabolism/microbiology, Legionella pneumophila/drug effects/*growth & development, Molecular Weight | Pathogenicity |
| 25023637 | Role of biofilm in protection of the replicative form of Legionella pneumophila. | Andreozzi E, Di Cesare A, Sabatini L, Chessa E, Sisti D, Rocchi M, Citterio B | Curr Microbiol | 10.1007/s00284-014-0648-y | 2014 | Bacterial Proteins/analysis/genetics, Biofilms/*growth & development, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Legionella pneumophila/genetics/growth & development/*physiology, *Microbial Viability, Peptidylprolyl Isomerase/analysis/genetics, Real-Time Polymerase Chain Reaction | ||
| Pathogenicity | 25241149 | Legionella in water samples: how can you interpret the results obtained by quantitative PCR? | Ditommaso S, Ricciardi E, Giacomuzzi M, Arauco Rivera SR, Zotti CM | Mol Cell Probes | 10.1016/j.mcp.2014.09.002 | 2014 | Algorithms, Azides/pharmacology, DNA, Bacterial/analysis, Legionella pneumophila/drug effects/genetics/growth & development/*isolation & purification, Microbial Viability/drug effects, Molecular Typing/methods, Polymerase Chain Reaction/*methods, Propidium/analogs & derivatives/pharmacology, Water Microbiology | Enzymology |
| Metabolism | 25253612 | The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna. | Tyson JY, Vargas P, Cianciotto NP | Microbiology (Reading) | 10.1099/mic.0.082750-0 | 2014 | Bacterial Proteins/genetics/*metabolism, Bacterial Secretion Systems, Hartmannella/*microbiology, Legionella pneumophila/metabolism/*physiology, Schizopyrenida/*microbiology, Virulence Factors/genetics/*metabolism | |
| Phylogeny | 25406235 | Legionella norrlandica sp. nov., isolated from the biopurification systems of wood processing plants. | Rizzardi K, Winiecka-Krusnell J, Ramliden M, Alm E, Andersson S, Byfors S | Int J Syst Evol Microbiol | 10.1099/ijs.0.068940-0 | 2014 | Amoeba/microbiology, DNA, Bacterial/genetics, DNA, Intergenic/genetics, Genes, Bacterial, Legionella/*classification/genetics/isolation & purification, Molecular Sequence Data, *Phylogeny, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNA, Virulence Factors/genetics, Wood/*microbiology | Enzymology |
| Pathogenicity | 25817814 | Effects of oakmoss and its components on Acanthamoeba castellanii ATCC 30234 and the uptake of Legionella pneumophila JCM 7571 (ATCC 33152) into A. castellanii. | Nomura H, Isshiki Y, Sakuda K, Sakuma K, Kondo S | Biocontrol Sci | 10.4265/bio.20.59 | 2015 | Acanthamoeba castellanii/*drug effects/*microbiology/physiology, Antiprotozoal Agents/chemistry/*pharmacology, Cell Survival/drug effects, Endocytosis/*drug effects, Inhibitory Concentration 50, Legionella pneumophila/*growth & development, Resins, Plant/chemistry/*pharmacology, Terpenes/chemistry/*pharmacology, Time Factors | |
| Metabolism | 27185787 | Iron Limitation Triggers Early Egress by the Intracellular Bacterial Pathogen Legionella pneumophila. | O'Connor TJ, Zheng H, VanRheenen SM, Ghosh S, Cianciotto NP, Isberg RR | Infect Immun | 10.1128/IAI.01306-15 | 2016 | Bacterial Proteins/genetics, Gene Order, Iron/*metabolism, Legionella pneumophila/*metabolism, Legionnaires' Disease/*metabolism/*microbiology, Macrophages/immunology/metabolism/microbiology, Mutation | |
| Genetics | 27491976 | Draft Genome Sequences of Legionella pneumophila JR32 and Lp01 Laboratory Strains Domesticated in Japan. | Maita C, Matushita M, Okubo T, Matsuo J, Miyake M, Nagai H, Yamaguchi H | Genome Announc | 10.1128/genomeA.00791-16 | 2016 | ||
| 27684472 | Genomic Analysis Reveals Novel Diversity among the 1976 Philadelphia Legionnaires' Disease Outbreak Isolates and Additional ST36 Strains. | Mercante JW, Morrison SS, Desai HP, Raphael BH, Winchell JM | PLoS One | 10.1371/journal.pone.0164074 | 2016 | |||
| Stress | 28609649 | Resistance of Legionella and Acanthamoeba mauritaniensis to heat treatment as determined by relative and quantitative polymerase chain reactions. | Dobrowsky PH, Khan S, Khan W | Environ Res | 10.1016/j.envres.2017.06.003 | 2017 | Acanthamoeba/genetics/microbiology/*physiology, *Hot Temperature, Legionella/genetics/*physiology, Real-Time Polymerase Chain Reaction | |
| Metabolism | 29037504 | An investigation of virulence factors of Legionella pneumophila environmental isolates. | Arslan-Aydogdu EO, Kimiran A | Braz J Microbiol | 10.1016/j.bjm.2017.03.012 | 2017 | Animals, Bacterial Proteins/genetics/*metabolism, Environmental Microbiology, Female, Humans, Legionella pneumophila/genetics/isolation & purification/*metabolism, Legionnaires' Disease/microbiology, Macrophages/microbiology, Mice, Mice, Inbred BALB C, Turkey/epidemiology, Virulence Factors/genetics/*metabolism | Pathogenicity |
| Pathogenicity | 30682021 | Using an optimal set of features with a machine learning-based approach to predict effector proteins for Legionella pneumophila. | Esna Ashari Z, Brayton KA, Broschat SL | PLoS One | 10.1371/journal.pone.0202312 | 2019 | Bacterial Proteins/*genetics, Humans, Legionella pneumophila/*genetics, Legionnaires' Disease/genetics, *Models, Genetic, *Support Vector Machine, Type IV Secretion Systems/*genetics, Virulence Factors/*genetics | |
| Pathogenicity | 30683743 | Chlorine and Monochloramine Disinfection of Legionella pneumophila Colonizing Copper and Polyvinyl Chloride Drinking Water Biofilms. | Buse HY, J Morris B, Struewing IT, Szabo JG | Appl Environ Microbiol | 10.1128/AEM.02956-18 | 2019 | Biofilms/*drug effects/growth & development, Chloramines/*pharmacology, Chlorine/*pharmacology, Colony Count, Microbial, *Copper, DNA, Bacterial/isolation & purification, Disinfectants/pharmacology, Disinfection/*methods, Drinking Water/*microbiology, Legionella pneumophila/*drug effects/genetics/growth & development, *Polyvinyl Chloride, RNA, Ribosomal, 16S/genetics, Water Microbiology, Water Supply | Phylogeny |
| Pathogenicity | 31246988 | Legionella pneumophila p45 element influences host cell entry and sensitivity to sodium. | Christensen LM, Sule P, Strain M, Cirillo JD | PLoS One | 10.1371/journal.pone.0218941 | 2019 | Animals, Bacterial Proteins/genetics, Biofilms, Cell Line, DNA Transposable Elements/*genetics, DNA, Bacterial/genetics, Humans, Legionella pneumophila/genetics/isolation & purification/*pathogenicity, Legionnaires' Disease/metabolism/*microbiology, Mice, Sodium/*metabolism, Virulence | Metabolism |
| Pathogenicity | 31405864 | Antibiotic Resistance and Azithromycin Resistance Mechanism of Legionella pneumophila Serogroup 1 in China. | Jia X, Ren H, Nie X, Li Y, Li J, Qin T | Antimicrob Agents Chemother | 10.1128/AAC.00768-19 | 2019 | Animals, Anti-Bacterial Agents/*pharmacology, Azithromycin/*pharmacology, Cell Line, China, Drug Resistance, Microbial/drug effects/*genetics, Legionella pneumophila/*drug effects, Legionnaires' Disease/*drug therapy/*microbiology, Macrophages/microbiology, Mice, Microbial Sensitivity Tests/methods, Serogroup | |
| 31860715 | Convolutional neural network-based annotation of bacterial type IV secretion system effectors with enhanced accuracy and reduced false discovery. | Hong J, Luo Y, Mou M, Fu J, Zhang Y, Xue W, Xie T, Tao L, Lou Y, Zhu F | Brief Bioinform | 10.1093/bib/bbz120 | 2020 | Algorithms, *Neural Networks, Computer, Position-Specific Scoring Matrices, *Type IV Secretion Systems | ||
| 32050878 | [Investigation of the Incidence of Legionella and Free-Living Amoebae in Swimming Pool Waters and Biofilm Specimens in Istanbul by Different Methods]. | Zeybek Z, Turkmen A | Mikrobiyol Bul | 10.5578/mb.68962 | 2020 | *Amoeba/physiology, *Biofilms, *Environmental Monitoring/methods, Incidence, *Legionella/physiology, *Swimming Pools, Turkey, *Water/parasitology, *Water Microbiology | ||
| Pathogenicity | 32209684 | Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets. | Swart AL, Steiner B, Gomez-Valero L, Schutz S, Hannemann M, Janning P, Irminger M, Rothmeier E, Buchrieser C, Itzen A, Panse VG, Hilbi H | mBio | 10.1128/mBio.00405-20 | 2020 | A549 Cells, Animals, Bacterial Proteins/*genetics, Dictyostelium/microbiology, *Evolution, Molecular, HEK293 Cells, *Host-Pathogen Interactions, Humans, Legionella pneumophila/*genetics/pathogenicity, Macrophages/microbiology, Mice, RAW 264.7 Cells, ran GTP-Binding Protein/*genetics/metabolism | Metabolism |
| Cultivation | 32245064 | Legionella Detection in Water Networks as per ISO 11731:2017: Can Different Filter Pore Sizes and Direct Placement on Culture Media Influence Laboratory Results? | De Giglio O, Diella G, Trerotoli P, Consonni M, Palermo R, Tesauro M, Lagana P, Serio G, Montagna MT | Int J Environ Res Public Health | 10.3390/ijerph17062077 | 2020 | Culture Media, Escherichia coli/isolation & purification, Humans, *Legionella pneumophila/isolation & purification, Legionnaires' Disease/epidemiology, Water, *Water Microbiology, Water Supply | Enzymology |
| Stress | 33608288 | The Tail-Specific Protease Is Important for Legionella pneumophila To Survive Thermal Stress in Water and inside Amoebae. | Saoud J, Mani T, Faucher SP | Appl Environ Microbiol | 10.1128/AEM.02975-20 | 2021 | Amoeba/*microbiology, Bacterial Proteins/*genetics, Endopeptidases/*genetics, Hot Temperature, Legionella pneumophila/*genetics, Thermotolerance/*genetics, Water | |
| 34151181 | Re-opening hairdressing salons, barber shops and gyms following COVID-19 lockdown: reducing risks from Legionella species through successful domestic steam disinfection of showerheads. | Millar BC, Ferris J, Murphy A, Reid N, Moore JE | Access Microbiol | 10.1099/acmi.0.000229 | 2021 | |||
| Pathogenicity | 34303751 | A new MALDI-TOF approach for the quick sequence type identification of Legionella pneumophila. | Blanco S, Sanz C, Gutierrez MP, Simarro M, Lopez I, Escribano I, Eiros JM, Zarzosa P, Orduna A, Lopez JC, March GA | J Microbiol Methods | 10.1016/j.mimet.2021.106292 | 2021 | Humans, Legionella pneumophila/*genetics/isolation & purification, Molecular Typing/*methods, Multilocus Sequence Typing/methods, Sequence Analysis, DNA, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods | Transcriptome |
| Pathogenicity | 35506506 | Novel axially symmetric and unsymmetric silicon(IV) phthalocyanines having anti-inflammatory groups: synthesis, characterization and their biological properties. | Gumusgoz Celik G, Gonca S, Sahin B, Ozdemir S, Atilla D, Gurek AG | Dalton Trans | 10.1039/d2dt00652a | 2022 | Anti-Bacterial Agents/chemistry, *Anti-Infective Agents/chemistry, Anti-Inflammatory Agents/pharmacology, Anti-Inflammatory Agents, Non-Steroidal/pharmacology, *Antioxidants/chemistry, Chelating Agents/pharmacology, Diclofenac, Escherichia coli, Indoles/chemistry/pharmacology, Isoindoles, Microbial Sensitivity Tests, Silicones/pharmacology |
Reference
| @id | authors | catalogue | doi/url | title | journal | pubmed |
|---|---|---|---|---|---|---|
| 3193 | Curators of the DSMZ | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 7513) | https://www.dsmz.de/collection/catalogue/details/culture/DSM-7513 | |||
| 20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M. | 10.1099/ijsem.0.004332 | List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ | |||
| 20218 | Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P. | 10.1016/j.syapm.2013.11.002 | StrainInfo introduces electronic passports for microorganisms. | Syst Appl Microbiol. 37: 42-50 2014 | 24321274 | |
| 40120 | Curators of the CIP | https://brclims.pasteur.fr/brcWeb/souche/detail/1/15697 | ||||
| 45204 | Curators of the CCUG | Culture Collection University of Gothenburg (CCUG) (CCUG 9568) | https://www.ccug.se/strain?id=9568 | |||
| 66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |||
| 67770 | Curators of the JCM | https://jcm.brc.riken.jp/en/ | ||||
| 68377 | Automatically annotated from API NH | |||||
| 68382 | Automatically annotated from API zym | |||||
| 69479 | João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich. | https://microbeatlas.org/ | MicrobeAtlas 1.0 beta | |||
| 76185 | Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J. | 10.60712/SI-ID40359.1 | StrainInfo: A central database for resolving microbial strain identifiers | |||
| 121898 | Curators of the CIP | Collection of Institut Pasteur (CIP 103854) | https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20103854 |