Strain identifier

BacDive ID: 6403

Type strain: No

Species: Lactobacillus acidophilus

Strain Designation: A 16

Strain history: <- E. Lauer <- F. Gasser <- M.E. Sharpe, A16

NCBI tax ID(s): 1226676 (strain), 1579 (species)

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General

@ref: 3477

BacDive-ID: 6403

DSM-Number: 9126

keywords: genome sequence, Bacteria, Gram-positive, human pathogen

description: Lactobacillus acidophilus A 16 is a Gram-positive human pathogen of the family Lactobacillaceae.

NCBI tax id

NCBI tax idMatching level
1226676strain
1579species

strain history

  • @ref: 3477
  • history: <- E. Lauer <- F. Gasser <- M.E. Sharpe, A16

doi: 10.13145/bacdive6403.20240916.9.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacillota
  • domain: Bacteria
  • phylum: Bacillota
  • class: Bacilli
  • order: Lactobacillales
  • family: Lactobacillaceae
  • genus: Lactobacillus
  • species: Lactobacillus acidophilus
  • full scientific name: Lactobacillus acidophilus (Moro 1900) Hansen and Mocquot 1970 (Approved Lists 1980)

  • synonyms

    • @ref: 20215
    • synonym: Bacillus acidophilus

@ref: 3477

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Lactobacillales

family: Lactobacillaceae

genus: Lactobacillus

species: Lactobacillus acidophilus

full scientific name: Lactobacillus acidophilus (Moro 1900) Hansen and Mocquot 1970

strain designation: A 16

type strain: no

Morphology

cell morphology

@refgram stainconfidencemotility
69480positive92.59
6948093no

Culture and growth conditions

culture medium

  • @ref: 3477
  • name: MRS MEDIUM (DSMZ Medium 11)
  • growth: yes
  • link: https://mediadive.dsmz.de/medium/11
  • composition: Name: MRS MEDIUM (DSMZ Medium 11) Composition: Glucose 20.0 g/l Casein peptone 10.0 g/l Meat extract 10.0 g/l Na-acetate 5.0 g/l Yeast extract 5.0 g/l (NH4)3 citrate 2.0 g/l K2HPO4 2.0 g/l Tween 80 1.0 g/l MgSO4 x 7 H2O 0.2 g/l MnSO4 x H2O 0.05 g/l Distilled water

culture temp

  • @ref: 3477
  • growth: positive
  • type: growth
  • temperature: 37

Physiology and metabolism

spore formation

@refspore formationconfidence
69480no90.855
69481no100

murein

  • @ref: 3477
  • murein short key: A11.31
  • type: A4alpha L-Lys-D-Asp

metabolite utilization

@refmetaboliteutilization activitykind of utilization testedChebi-ID
68371Potassium 5-ketogluconate-builds acid from
68371Potassium 2-ketogluconate-builds acid from
68371gluconate-builds acid from24265
68371L-arabitol-builds acid from18403
68371D-arabitol-builds acid from18333
68371L-fucose-builds acid from18287
68371D-fucose-builds acid from28847
68371D-tagatose-builds acid from16443
68371D-lyxose-builds acid from62318
68371turanose-builds acid from32528
68371xylitol-builds acid from17151
68371glycogen-builds acid from28087
68371starch-builds acid from28017
68371melezitose-builds acid from6731
68371inulin-builds acid from15443
68371sucrose+builds acid from17992
68371melibiose-builds acid from28053
68371maltose+builds acid from17306
68371esculin+builds acid from4853
68371arbutin-builds acid from18305
68371methyl alpha-D-glucopyranoside-builds acid from320061
68371methyl alpha-D-mannoside-builds acid from43943
68371D-sorbitol-builds acid from17924
68371D-mannitol-builds acid from16899
68371myo-inositol-builds acid from17268
68371galactitol-builds acid from16813
68371L-rhamnose-builds acid from62345
68371L-sorbose-builds acid from17266
68371D-fructose+builds acid from15824
68371D-glucose+builds acid from17634
68371methyl beta-D-xylopyranoside-builds acid from74863
68371ribitol-builds acid from15963
68371L-xylose-builds acid from65328
68371D-xylose-builds acid from65327
68371D-ribose-builds acid from16988
68371L-arabinose-builds acid from30849
68371D-arabinose-builds acid from17108
68371erythritol-builds acid from17113
68371glycerol-builds acid from17754

API 50CHac

@refQGLYERYDARALARARIBDXYLLXYLADOMDXGALGLUFRUMNESBERHADULINOMANSORMDMMDGNAGAMYARBESCSALCELMALLACMELSACTREINUMLZRAFAMDGLYGXLTGENTURLYXTAGDFUCLFUCDARLLARLGNT2KG5KG
3477----------++++--------+--+++++-++--+--------------
3477----------++++--------+--+++++-++--+---+----------
3477-----------++------------+--+--++--+--------------
3477-----------++------------+--+--+------------------
3477----------++++--------++/--+++++-++--+---+----------

Safety information

risk assessment

  • @ref: 3477
  • pathogenicity human: yes, in single cases
  • biosafety level: 1
  • biosafety level comment: Risk group (German classification)

Sequence information

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Lactobacillus acidophilus DSM 9126GCA_000469745scaffoldncbi1226676
66792Lactobacillus acidophilus DSM 91261226676.3wgspatric1226676

Genome-based predictions

predictions

@reftraitmodeldescriptionpredictionconfidencetraining_data
69481spore-formingspore-formingAbility to form endo- or exosporesno100no
69480gram-positivegram-positivePositive reaction to Gram-stainingyes92.59no
69480anaerobicanaerobicAbility to grow under anoxygenic conditions (including facultative anaerobes)no71.826no
69480aerobicaerobicAbility to grow under oxygenic conditions (including facultative aerobes)no95.55no
69480spore-formingspore-formingAbility to form endo- or exosporesno90.855no
69480thermophilicthermophileAbility to grow at temperatures above or equal to 45°Cno97.5yes
69480flagellatedmotile2+Ability to perform flagellated movementno93no

External links

@ref: 3477

culture collection no.: DSM 9126, ATCC 13651, NCDO 1360

straininfo link

  • @ref: 75876
  • straininfo: 14521

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Enzymology6419677Production and properties of alpha-glucosidase from Lactobacillus acidophilus.Li KB, Chan KYAppl Environ Microbiol10.1128/aem.46.6.1380-1387.19831983Carbohydrates/pharmacology, Cations, Cytoplasm/enzymology, Glucosidases/*biosynthesis, Hydrogen-Ion Concentration, Lactobacillus acidophilus/*enzymology, Temperature, Urea/pharmacology, alpha-Glucosidases/*biosynthesis/metabolismBiotechnology
Genetics23969059Draft Genome Sequences of Five Strains of Lactobacillus acidophilus, Strain CIP 76.13T, Isolated from Humans, Strains CIRM-BIA 442 and CIRM-BIA 445, Isolated from Dairy Products, and Strains DSM 20242 and DSM 9126 of Unknown Origin.Falentin H, Cousin S, Clermont D, Creno S, Ma L, Chuat V, Loux V, Rudiger P, Bizet C, Bouchier CGenome Announc10.1128/genomeA.00658-132013Phylogeny
Pathogenicity29224862In vitro investigation of anticancer, antihypertensive, antidiabetic, and antioxidant activities of camel milk fermented with camel milk probiotic: A comparative study with fermented bovine milk.Ayyash M, Al-Dhaheri AS, Al Mahadin S, Kizhakkayil J, Abushelaibi AJ Dairy Sci10.3168/jds.2017-134002017Animals, Antihypertensive Agents/*pharmacology, Antineoplastic Agents/*pharmacology, Antioxidants/*metabolism, Caco-2 Cells, Camelus, Cattle, Cell Proliferation/drug effects, Enzyme Activation/drug effects, Fermentation, HeLa Cells, Humans, Hypoglycemic Agents/*pharmacology, Lactobacillus acidophilus/chemistry, Lactococcus lactis/*chemistry, MCF-7 Cells, Milk/*chemistry/microbiology, Probiotics/administration & dosage/pharmacologyMetabolism

Reference

@idauthorscataloguedoi/urltitle
3477Curators of the DSMZLeibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 9126)https://www.dsmz.de/collection/catalogue/details/culture/DSM-9126
20215Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.10.1099/ijsem.0.004332List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
68371Automatically annotated from API 50CH acid
69480Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesPredictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
69481Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch10.21203/rs.3.rs-2527258/v1Predictions based on the model GenomeNet Sporulation v. 1
75876Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.10.60712/SI-ID14521.1StrainInfo: A central database for resolving microbial strain identifiers