Archive BacDiveID:10.13145/bacdive5316.20230509.8.1

Strain identifier

BacDive ID: 5316

Type strain:

Species: Enterococcus hirae

Strain history: CIP <- 1953, ATCC, Streptococcus faecalis <- E. Snell, Streptococcus lactis R

NCBI tax ID(s): 768486 (strain), 1354 (species)

For citation purpose refer to the digital object identifier (doi) of the current version.

General

@ref: 8584

BacDive-ID: 5316

DSM-Number: 20160

keywords: genome sequence, 16S sequence, Bacteria, microaerophile, spore-forming, mesophilic, Gram-positive, human pathogen

description: Enterococcus hirae DSM 20160 is a microaerophile, spore-forming, mesophilic human pathogen of the family Enterococcaceae.

NCBI tax id

NCBI tax id	Matching level
768486	strain
1354	species

strain history

@ref	history
8584	<- ATCC; ATCC 8043 <- E. E. Snell; (Streptococcus lactis)
67770	ATCC 8043 <-- E. E. Snell strain R.
119908	CIP <- 1953, ATCC, Streptococcus faecalis <- E. Snell, Streptococcus lactis R

doi: 10.13145/bacdive5316.20230509.8.1

Name and taxonomic classification

LPSN

@ref: 20215
description: domain/bacteria
keyword: phylum/bacillota
domain: Bacteria
phylum: Bacillota
class: Bacilli
order: Lactobacillales
family: Enterococcaceae
genus: Enterococcus
species: Enterococcus hirae
full scientific name: Enterococcus hirae Farrow and Collins 1985

@ref: 8584

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Lactobacillales

family: Enterococcaceae

genus: Enterococcus

species: Enterococcus hirae

full scientific name: Enterococcus hirae Farrow and Collins 1985

type strain: yes

Morphology

cell morphology

@ref	gram stain	confidence	cell shape	motility
69480	positive	100
119908	positive		coccus-shaped	no

colony morphology

@ref	type of hemolysis	incubation period
8584	gamma	1-2 days
119908

Culture and growth conditions

culture medium

@ref	name	growth	link	composition
8584	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	yes	https://mediadive.dsmz.de/medium/693	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
8584	TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)	yes	https://mediadive.dsmz.de/medium/92	Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water
37346	MEDIUM 29- Brain heart agar	yes		Distilled water make up to (1000.000 ml);Brain heart infusion agar (52.000 g)
119908	CIP Medium 29	yes	https://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=29

culture temp

@ref	growth	type	temperature	range
8584	positive	growth	37	mesophilic
37346	positive	growth	30	mesophilic
67770	positive	growth	37	mesophilic
119908	positive	growth	10-45

Physiology and metabolism

oxygen tolerance

@ref	oxygen tolerance
8584	microaerophile
119908	facultative anaerobe

spore formation

@ref	spore formation	confidence
69481	yes	94
69480	no	99.927

halophily

@ref: 119908
salt: NaCl
growth: positive
tested relation: growth
concentration: 6.5 %

murein

@ref: 8584
murein short key: A11.31
type: A4alpha L-Lys-D-Asp

metabolite utilization

@ref	Chebi-ID	metabolite	utilization activity	kind of utilization tested
119908	4853	esculin	+	hydrolysis
119908	606565	hippurate	-	hydrolysis
119908	17632	nitrate	-	reduction
119908	16301	nitrite	-	reduction
68381	29016	arginine	+	hydrolysis
68381	16988	D-ribose	+	builds acid from
68381	16899	D-mannitol	-	builds acid from
68381	30911	sorbitol	-	builds acid from
68381	27082	trehalose	+	builds acid from
68381	16634	raffinose	-	builds acid from
68381	17992	sucrose	+	builds acid from
68381	30849	L-arabinose	-	builds acid from
68381	18333	D-arabitol	-	builds acid from
68381	40585	alpha-cyclodextrin	+	builds acid from
68381	28087	glycogen	-	builds acid from
68381	17306	maltose	+	builds acid from
68381	6731	melezitose	-	builds acid from
68381	320055	methyl beta-D-glucopyranoside	+	builds acid from
68381	16199	urea	-	hydrolysis

metabolite production

@ref: 68381
Chebi-ID: 15688
metabolite: acetoin
production: yes

metabolite tests

@ref	Chebi-ID	metabolite	voges-proskauer-test
68381	15688	acetoin	+
119908	15688	acetoin	-

enzymes

@ref	value	activity	ec
8584	cytochrome-c oxidase	-	1.9.3.1
68382	alpha-fucosidase	-	3.2.1.51
68382	alpha-mannosidase	-	3.2.1.24
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52
68382	beta-glucosidase	+	3.2.1.21
68382	alpha-glucosidase	+	3.2.1.20
68382	beta-glucuronidase	-	3.2.1.31
68382	beta-galactosidase	+	3.2.1.23
68382	alpha-galactosidase	+	3.2.1.22
68382	naphthol-AS-BI-phosphohydrolase	-
68382	acid phosphatase	+	3.1.3.2
68382	alpha-chymotrypsin	+	3.4.21.1
68382	trypsin	-	3.4.21.4
68382	cystine arylamidase	+	3.4.11.3
68382	valine arylamidase	-
68382	leucine arylamidase	+	3.4.11.1
68382	lipase (C 14)	-
68382	esterase lipase (C 8)	+
68382	esterase (C 4)	+
68382	alkaline phosphatase	-	3.1.3.1
68381	urease	-	3.5.1.5
68381	pyrrolidonyl arylamidase	+	3.4.19.3
68381	beta-galactosidase	+	3.2.1.23
68381	Alanyl-Phenylalanyl-Proline arylamidase	-
68381	alkaline phosphatase	-	3.1.3.1
68381	alpha-galactosidase	+	3.2.1.22
68381	beta-glucuronidase	-	3.2.1.31
68381	beta-glucosidase	+	3.2.1.21
68381	arginine dihydrolase	+	3.5.3.6
119908	oxidase	-
119908	beta-galactosidase	+	3.2.1.23
119908	alcohol dehydrogenase	-	1.1.1.1
119908	catalase	-	1.11.1.6
119908	gamma-glutamyltransferase	-	2.3.2.2
119908	lysine decarboxylase	-	4.1.1.18
119908	ornithine decarboxylase	-	4.1.1.17

API zym

@ref	Control	Alkaline phosphatase	Esterase	Esterase Lipase	Lipase	Leucine arylamidase	Valine arylamidase	Cystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
119908	-	-	+	+	-	+	-	+	-	+	+	-	+	+	-	+	+	+	-	-

API rID32STR

@ref	ADH Arg	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	CDEX	VP	APPA	beta GAL	PyrA	beta NAG	GTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Mbeta DG	TAG	beta MAN	URE
8584	+	+	+	-	+	-	+	-	-	+/-	+	-	+	-	-	+	+	-	+	+	+	+	-	-	-	+	+	-	+	+	-	-
8584	+	+	+	-	+	-	+	-	-	-	+	-	+	-	-	+	+	-	+	+	+	+	+/-	-	-	+	+	-	+	+/-	-	-
8584	+	+	+	-	+	-	+	-	-	-	+	-	+	-	-	+	+	-	+	+	+	+	-	-	-	+	+	-	+	-	-	-
8584	+	+	+	-	+	-	+	-	-	-	+	-	+	-	-	+	+	-	+	+	-	+	-	-	-	+	-	-	+	-	-	-
8584	+	+	+	-	+	-	+	-	-	-	+	-	+	-	-	+	+	-	+	+	-	+	-	-	-	+	+	-	+	+/-	-	-
8584	+	+	-	-	+	-	+	-	-	-	+	-	+	-	-	+	+	-	+	+	+/-	+	-	-	-	+	-	-	+	+/-	-	-
8584	+	+	+	-	+	-	+	-	-	-	+	-	+	-	-	+	+	-	+	+	+	+	+	-	-	+	+	-	+	-	+	-
8584	+	+	+	-	+	-	+	-	-	-	+	-	+	-	-	+	+	-	+	+	-	+/-	-	-	+	+	+	-	+	-	-	-

API biotype100

@ref	GLU	FRU	GAL	TRE	MNE	SBE	MEL	SAC	RAF	MTE	MAL	LAC	LTE	MbGa	MaGa	CEL	GEN	MbGu	ESC	RIB	ARA	XYL	PLE	RHA	FUC	MLZ	DARL	LARL	XLT	DUL	TAG	GLY	INO	MAN	MTL	TUR	SOR	ADO	HBG	LYX	ERY	MDG	3MDG	SAT	MUC	LTAT	DTAT	MTAT	DMLT	LMLT	CATE	TATE	TTE	CIT	GRT	GAT	2KG	5KG	TRY	NAG	GNT	PAC	PAT	pOBE	QAT	GTE	mOBE	BAT	PPAT	CMT	TGE	BET	PCE	ABT	HIN	LAT	CAP	CYT	HIS	SUC	FUM	GRE	GYT	AVT	ETN	TTN	GLN	ITA	3OBU	APT	GTT	PRO	DALA	LALA	SER	MNT	PROP	TYR	2KT
119908	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

taxonmaps

@ref: 69479
File name: preview.99_23.png
url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_13;96_19;97_19;98_22;99_23&stattab=map
Last taxonomy: Enterococcus
16S sequence: Y18354
Sequence Identity:
Total samples: 55544
soil counts: 1007
aquatic counts: 2532
animal counts: 51351
plant counts: 654

Safety information

risk assessment

@ref	pathogenicity human	pathogenicity animal	biosafety level	biosafety level comment
8584	yes	yes	2	Risk group (German classification)
119908			2	Risk group (French classification)

Sequence information

16S sequences

@ref	description	accession	length	database	NCBI tax ID
20218	Enterococcus hirae gene for 16S rRNA, partial sequence, strain: JCM 8729	AB596942	1482	ena	1354
20218	Enterococcus hirae 16S ribosomal RNA gene, partial sequence	AF061011	1507	ena	1354
20218	Enterococcus hirae 16S rRNA gene, strain DSM20160	AJ276356	1535	ena	1354
20218	Enterococcus hirae 16S rRNA gene, strain LMG 6399	AJ301834	1787	ena	1354
20218	E.hirae 16S-23S rRNA spacer DNA	X87184	232	ena	1354
20218	E.hirae 16S rRNA gene, partial (strain ATTC 8043 (CCUG 18659))	Y12912	366	ena	1354
8584	Enterococcus hirae 16S rRNA gene	Y17302	1535	ena	1354
67770	Enterococcus hirae 16S rRNA gene, strain CECT279T	AJ420799	1514	ena	1354
67770	Enterococcus hirae gene for 16S ribosomal RNA, partial sequence, strain: JCM 8729	LC097067	1496	ena	1354
67770	Enterococcus hirae 16S rRNA gene	Y18354	1445	ena	1354

Genome sequences

@ref	description	accession	assembly level	database	NCBI tax ID
66792	Enterococcus hirae ATCC 9790	GCA_000271405	complete	ncbi	768486
66792	Enterococcus hirae ATCC 9790 Enterococcus hirae canine HQ MAG	GCA_905186115	complete	ncbi	768486
66792	Enterococcus hirae NCTC12367	GCA_901482525	contig	ncbi	1354
66792	Enterococcus hirae ATCC 9790	768486.3	complete	patric	768486
66792	Enterococcus hirae ATCC 9790	768486.10	wgs	patric	768486
66792	Enterococcus hirae ATCC 9790	768486.11	wgs	patric	768486
66792	Enterococcus hirae ATCC 9790	768486.24	plasmid	patric	768486
66792	Enterococcus hirae ATCC 9790 strain Enterococcus hirae canine HQ MAG	768486.35	complete	patric	768486
66792	Enterococcus hirae strain DSM 20160	1354.25	wgs	patric	1354
66792	Enterococcus hirae strain FDAARGOS_1123	1354.364	complete	patric	1354
66792	Enterococcus hirae strain NCTC12367	1354.212	wgs	patric	1354
66792	Enterococcus hirae ATCC 8043	2558860905	draft	img	768486
66792	Enterococcus hirae ATCC 9790	2545824653	draft	img	768486
66792	Enterococcus hirae ATCC 9790	2521172711	complete	img	768486
67770	Enterococcus hirae ATCC 9790	GCA_000393835	scaffold	ncbi	768486
67770	Enterococcus hirae ATCC 9790	GCA_000407425	contig	ncbi	768486
67770	Enterococcus hirae DSM 20160	GCA_001885955	contig	ncbi	1354
66792	Enterococcus hirae DSM 20160	GCA_029814255	complete	ncbi	1354

GC content

@ref	GC-content	method
8584	38.0
67770	38	thermal denaturation, midpoint method (Tm)

Genome-based predictions

predictions

trait	prediction	confidence	training_data
spore-forming	yes	94	no
motile	no	95.491	no
flagellated	no	98.012	no
gram-positive	yes	94.293	no
anaerobic	no	95.135	yes
aerobic	no	97.081	yes
halophile	yes	93.506	no
spore-forming	no	92.941	no
thermophile	no	99.63	yes
glucose-util	yes	88.303	no
glucose-ferment	yes	89.506	no

External links

@ref: 8584

culture collection no.: DSM 20160, ATCC 8043, CCM 2423, CCUG 18659, CIP 53.48, CIP 82.112, JCM 8729, LMG 6399, NCDO 1258, NCIMB 6459, WDCM 00089, ATCC 9790, BCRC 11054, BCRC 12496, BCRC 80016, CCUG 1332, CCUG 19917, CECT 279, CECT 294, CECT 302, CFBP 4250, CGMCC 1.2140, HAMBI 1709, HAMBI 644, IAM 1262, IFO 3181, KCTC 2022, KCTC 3616, NBRC 3181, NCCB 46070, NCCB 58005, NCIMB 8123, NCIMB 8191, NCTC 12367, VKM B-2107, VTT E-97046, NCDO 997, NCTC 6459

straininfo link

@ref: 74805
straininfo: 91205

literature

topic	Pubmed-ID	title	authors	journal	DOI	year	mesh	topic2
Genetics	1328152	Gene structure of Enterococcus hirae (Streptococcus faecalis) F1F0-ATPase, which functions as a regulator of cytoplasmic pH.	Shibata C, Ehara T, Tomura K, Igarashi K, Kobayashi H	J Bacteriol	10.1128/jb.174.19.6117-6124.1992	1992	Amino Acid Sequence, Base Sequence, Chromosome Mapping, Cloning, Molecular, Cytoplasm/metabolism, DNA Mutational Analysis, Enterococcus faecalis/genetics, Genes, Bacterial/genetics, Hydrogen-Ion Concentration, Molecular Sequence Data, Promoter Regions, Genetic/genetics, Proton-Translocating ATPases/genetics, RNA, Messenger/genetics, Transcription, Genetic	Enzymology
Enzymology	1347040	Cloning and sequence analysis of the muramidase-2 gene from Enterococcus hirae.	Chu CP, Kariyama R, Daneo-Moore L, Shockman GD	J Bacteriol	10.1128/jb.174.5.1619-1625.1992	1992	Amino Acid Sequence, Base Sequence, Cloning, Molecular, Enterococcus/genetics, Enterococcus faecalis/genetics, Molecular Sequence Data, Muramidase/genetics/metabolism, N-Acetylmuramoyl-L-alanine Amidase/genetics, Repetitive Sequences, Nucleic Acid, Sequence Homology, Nucleic Acid	Genetics
Metabolism	1362171	The autolytic ('suicidase') system of Enterococcus hirae: from lysine depletion autolysis to biochemical and molecular studies of the two muramidases of Enterococcus hirae ATCC 9790.	Shockman GD	FEMS Microbiol Lett	10.1111/j.1574-6968.1992.tb14050.x	1992	Amino Acid Sequence, Autolysis, Binding Sites, Enterococcus/genetics/metabolism, Genes, Bacterial, Molecular Sequence Data, Muramidase/genetics/metabolism, N-Acetylmuramoyl-L-alanine Amidase/genetics/metabolism	Genetics
Enzymology	1577692	Extracellular and cellular distribution of muramidase-2 and muramidase-1 of Enterococcus hirae ATCC 9790.	Kariyama R, Shockman GD	J Bacteriol	10.1128/jb.174.10.3236-3241.1992	1992	Antibodies, Monoclonal, Enterococcus/enzymology, Guanidines, Isoenzymes, Muramidase/immunology/metabolism, Protein Denaturation, Proteoglycans/chemistry/immunology/metabolism, Subcellular Fractions/enzymology	Metabolism
	1718341	Relationship of the chemical structure and immunobiological activities of lipoteichoic acid from Streptococcus faecalis (Enterococcus hirae) ATCC 9790.	Tsutsui O, Kokeguchi S, Matsumura T, Kato K	FEMS Microbiol Immunol	10.1111/j.1574-6968.1991.tb04217.x	1991	Animals, Enterococcus faecalis/chemistry, Female, Fibrosarcoma/drug therapy, Interferons/biosynthesis, Interleukin-1/biosynthesis, Lipopolysaccharides/chemistry/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred ICR, Structure-Activity Relationship, Teichoic Acids/chemistry/immunology/*pharmacology, Tumor Necrosis Factor-alpha/biosynthesis
	1769542	Detection of penicillin-binding proteins immunologically related to penicillin-binding protein 5 of Enterococcus hirae ATCC 9790 in Enterococcus faecium and Enterococcus faecalis.	Ligozzi M, Aldegheri M, Predari SC, Fontana R	FEMS Microbiol Lett	10.1016/0378-1097(91)90498-y	1991	Bacterial Proteins, Blotting, Western, Carrier Proteins/analysis/immunology, Enterococcus/chemistry/immunology, Enterococcus faecalis/chemistry/immunology, Enterococcus faecium/chemistry/immunology, Hexosyltransferases, Immune Sera, Membrane Proteins/analysis/immunology, Muramoylpentapeptide Carboxypeptidase/analysis/immunology, Penicillin-Binding Proteins, Penicillins, *Peptidyl Transferases
Metabolism	1829347	Adaptation of Streptococcus mutans and Enterococcus hirae to acid stress in continuous culture.	Belli WA, Marquis RE	Appl Environ Microbiol	10.1128/aem.57.4.1134-1138.1991	1991	Adaptation, Physiological, Adenosine Triphosphatases/metabolism, Cell Membrane Permeability, Culture Media, Hydrogen-Ion Concentration, Kinetics, Streptococcus/growth & development/metabolism, Streptococcus mutans/growth & development/metabolism	Cultivation
Enzymology	1901041	Separation of the poly(glycerophosphate) lipoteichoic acids of Enterococcus faecalis Kiel 27738, Enterococcus hirae ATCC 9790 and Leuconostoc mesenteroides DSM 20343 into molecular species by affinity chromatography on concanavalin A.	Leopold K, Fischer W	Eur J Biochem	10.1111/j.1432-1033.1991.tb15839.x	1991	Chromatography, Affinity, Concanavalin A, Enterococcus faecalis/analysis, Glycerophosphates/analysis/chemistry, Glycosylation, Leuconostoc/analysis, Lipopolysaccharides/analysis/chemistry/isolation & purification, Teichoic Acids/analysis/chemistry/*isolation & purification	Phylogeny
Cultivation	1973928	Relationship between changes in buoyant density and formation of new sites of cell wall growth in cultures of streptococci (Enterococcus hirae ATCC 9790) undergoing a nutritional shift-up.	Higgins ML, Haines M, Whalen M, Glaser D, Bylund J	J Bacteriol	10.1128/jb.172.8.4415-4419.1990	1990	Cell Wall/physiology, Culture Media, Glutamates/pharmacology, Glutamic Acid, Kinetics, Leucine/metabolism, Peptidoglycan/biosynthesis, Streptococcus/drug effects/*growth & development/ultrastructure, Time Factors, Uracil/metabolism	Enzymology
Metabolism	2037534	Effect of non-beta-lactam antibiotics on penicillin-binding protein synthesis of Enterococcus hirae ATCC 9790.	Grossato A, Sartori R, Fontana R	J Antimicrob Chemother	10.1093/jac/27.3.263	1991	Bacitracin/pharmacology, Bacterial Proteins, Carrier Proteins/biosynthesis, Drug Synergism, Drug Therapy, Combination/pharmacology, Fosfomycin/pharmacology, Hexosyltransferases, Muramoylpentapeptide Carboxypeptidase/biosynthesis, Penicillin-Binding Proteins, Penicillins/metabolism, Peptidyl Transferases, Species Specificity, Streptococcus/metabolism, Vancomycin/pharmacology	Phylogeny
	2116916	Efficient electrotransformation of Enterococcus hirae with a new Enterococcus-Escherichia coli shuttle vector.	Solioz M, Waser M	Biochimie	10.1016/0300-9084(90)90084-t	1990	DNA, Bacterial/genetics, Electrodes, Escherichia coli/genetics, Plasmids, Streptococcus/genetics, *Transformation, Bacterial
Enzymology	2161844	Heterogeneity among the flavin-containing NADH peroxidases of group D streptococci. Analysis of the enzyme from Streptococcus faecalis ATCC 9790.	Miller H, Poole LB, Claiborne A	J Biol Chem	S0021-9258(19)38750-2	1990	Amino Acid Sequence, Anaerobiosis, Binding Sites, Chromatography, Chromatography, DEAE-Cellulose, Chromatography, Gel, Durapatite, Electrophoresis, Polyacrylamide Gel, Enterococcus faecalis/enzymology, Flavins/analysis, Hydroxyapatites, Isoenzymes/isolation & purification/metabolism, Kinetics, Molecular Sequence Data, Peptide Mapping, Peroxidases/antagonists & inhibitors/*isolation & purification/metabolism, Spectrophotometry, Trypsin	Phylogeny
Metabolism	2254261	Characterization of an Enterococcus hirae penicillin-binding protein 3 with low penicillin affinity.	Piras G, el Kharroubi A, van Beeumen J, Coeme E, Coyette J, Ghuysen JM	J Bacteriol	10.1128/jb.172.12.6856-6862.1990	1990	Amino Acid Sequence, Bacteria/genetics/metabolism, Bacterial Proteins, Carrier Proteins, Hexosyltransferases/chemistry/genetics/immunology/metabolism, Molecular Sequence Data, Molecular Weight, Multienzyme Complexes/chemistry/genetics/immunology/metabolism, Muramoylpentapeptide Carboxypeptidase, Penicillin G/metabolism, Penicillin Resistance, Penicillin-Binding Proteins, Peptide Mapping, Peptidyl Transferases/chemistry/genetics/immunology/*metabolism, Polymerase Chain Reaction, Serine Endopeptidases, Trypsin	Genetics
Enzymology	2361945	Properties of cell wall-associated DD-carboxypeptidase of Enterococcus hirae (Streptococcus faecium) ATCC 9790 extracted with alkali.	Kariyama R, Massidda O, Daneo-Moore L, Shockman GD	J Bacteriol	10.1128/jb.172.7.3718-3724.1990	1990	Cell Membrane/enzymology, Cell Wall/enzymology, Hydrogen-Ion Concentration, Kinetics, Molecular Weight, Muramoylpentapeptide Carboxypeptidase/isolation & purification/metabolism, Penicillin G/metabolism, Protein Binding, Protoplasts/enzymology, Streptococcus/enzymology, Ultracentrifugation/methods	Metabolism
Enzymology	2753858	The second peptidoglycan hydrolase of Streptococcus faecium ATCC 9790 covalently binds penicillin.	Dolinger DL, Daneo-Moore L, Shockman GD	J Bacteriol	10.1128/jb.171.8.4355-4361.1989	1989	Chromatography, Affinity, Kinetics, Molecular Weight, Muramidase/isolation & purification/metabolism, Penicillin G/metabolism, Peptidoglycan/isolation & purification/metabolism, Protein Binding, Streptococcus/*enzymology	Metabolism
Genetics	7806384	Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities.	Takada H, Kawabata Y, Arakaki R, Kusumoto S, Fukase K, Suda Y, Yoshimura T, Kokeguchi S, Kato K, Komuro T, et al.	Infect Immun	10.1128/iai.63.1.57-65.1995	1995	Acetylmuramyl-Alanyl-Isoglutamine/immunology, Animals, Antigens, Bacterial/chemistry/immunology/therapeutic use, Antineoplastic Agents/chemistry/immunology/therapeutic use, Carbohydrate Sequence, Cytokines/biosynthesis, Enterococcus/immunology, Fibrosarcoma/drug therapy, Glycolipids/pharmacology, Interferon-gamma/blood, Interleukin-6/blood, Lipopolysaccharides/chemistry/immunology/therapeutic use, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Molecular Sequence Data, Propionibacterium acnes/immunology, Sarcoma, Experimental/drug therapy, Teichoic Acids/chemistry/immunology/therapeutic use, Tumor Necrosis Factor-alpha/analysis
Metabolism	8056283	Characteristics of an ethidium efflux system in Enterococcus hirae.	Midgley M	FEMS Microbiol Lett	10.1111/j.1574-6968.1994.tb07017.x	1994	Drug Resistance, Microbial, Enterococcus/metabolism, Ethidium/antagonists & inhibitors/pharmacokinetics, Ion Transport/drug effects, Mutation, Onium Compounds/pharmacology, Organophosphorus Compounds/pharmacology	Enzymology
Enzymology	8458847	Identification of a genetic element (psr) which negatively controls expression of Enterococcus hirae penicillin-binding protein 5.	Ligozzi M, Pittaluga F, Fontana R	J Bacteriol	10.1128/jb.175.7.2046-2051.1993	1993	Amino Acid Sequence, Bacterial Proteins/biosynthesis/genetics, Base Sequence, Carrier Proteins/biosynthesis, Cloning, Molecular, Enterococcus/genetics, Escherichia coli/genetics, Gene Expression Regulation, Bacterial, Hexosyltransferases, Molecular Sequence Data, Muramoylpentapeptide Carboxypeptidase/biosynthesis, Mutagenesis, Open Reading Frames, Penicillin-Binding Proteins, Penicillins/pharmacology, Peptidyl Transferases, Recombinant Proteins/biosynthesis, Repressor Proteins/biosynthesis/*genetics, Restriction Mapping, Sequence Deletion	Genetics
Metabolism	8491737	Characterization of intergenic spacers in two rrn operons of Enterococcus hirae ATCC 9790.	Sechi LA, Daneo-Moore L	J Bacteriol	10.1128/jb.175.10.3213-3219.1993	1993	Base Sequence, Cloning, Molecular, DNA, Bacterial/metabolism, DNA, Ribosomal/genetics/metabolism, Deoxyribonucleases, Type II Site-Specific/metabolism, Enterococcus/genetics, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Ribosomal, 16S/genetics, RNA, Ribosomal, 23S/genetics, RNA, Transfer, Ala/genetics, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid, rRNA Operon/*genetics	Enzymology
Enzymology	8505293	Cloning and sequencing of the genes coding for the A and B subunits of vacuolar-type Na(+)-ATPase from Enterococcus hirae. Coexistence of vacuolar- and F0F1-type ATPases in one bacterial cell.	Takase K, Yamato I, Kakinuma Y	J Biol Chem	S0021-9258(19)50245-9	1993	Adenosine Triphosphatases/genetics/metabolism, Amino Acid Sequence, Base Sequence, Cation Transport Proteins, DNA, Bacterial/genetics/isolation & purification, Enterococcus/enzymology/genetics, Genes, Bacterial, Genomic Library, Macromolecular Substances, Molecular Sequence Data, Neurospora crassa/enzymology/genetics, Oligonucleotide Probes, Plants/enzymology/genetics, Proton-Translocating ATPases/metabolism, Restriction Mapping, Sequence Homology, Amino Acid, Vacuoles/enzymology	Metabolism
Pathogenicity	8589669	Cytokine-inducing glycolipids in the lipoteichoic acid fraction from Enterococcus hirae ATCC 9790.	Suda Y, Tochio H, Kawano K, Takada H, Yoshida T, Kotani S, Kusumoto S	FEMS Immunol Med Microbiol	10.1111/j.1574-695X.1995.tb00181.x	1995	Animals, Blood Cells/immunology, Chromatography, Enterococcus/chemistry/immunology, Glycolipids/chemistry/immunology/isolation & purification, Humans, Immunochemistry, In Vitro Techniques, Interleukin-6/biosynthesis, Limulus Test, Lipopolysaccharides/chemistry/immunology, Molecular Structure, Teichoic Acids/chemistry/immunology, Tumor Necrosis Factor-alpha/*biosynthesis	Enzymology
Metabolism	8752348	Evidence that the PBP 5 synthesis repressor (psr) of Enterococcus hirae is also involved in the regulation of cell wall composition and other cell wall-related properties.	Massidda O, Kariyama R, Daneo-Moore L, Shockman GD	J Bacteriol	10.1128/jb.178.17.5272-5278.1996	1996	Bacterial Proteins/genetics/metabolism, Bacteriolysis, Buffers, Cell Wall/chemistry/metabolism, Enterococcus/drug effects/genetics/metabolism, Muramidase/metabolism, Mutation, Osmotic Fragility, Penicillin G/pharmacology, Penicillin Resistance, Phosphates, Protoplasts, Repressor Proteins/genetics/*metabolism	Pathogenicity
Metabolism	8759860	Structure of the low-affinity penicillin-binding protein 5 PBP5fm in wild-type and highly penicillin-resistant strains of Enterococcus faecium.	Zorzi W, Zhou XY, Dardenne O, Lamotte J, Raze D, Pierre J, Gutmann L, Coyette J	J Bacteriol	10.1128/jb.178.16.4948-4957.1996	1996	Amino Acid Sequence, Bacterial Proteins, Base Sequence, Binding Sites, Carrier Proteins/biosynthesis/chemistry/metabolism, Chromosomes, Bacterial, DNA Primers, Enterococcus/genetics, Enterococcus faecium/drug effects/genetics/metabolism, Escherichia coli, Genes, Bacterial, Genes, Regulator, Hexosyltransferases, Humans, Kinetics, Models, Structural, Molecular Sequence Data, Muramoylpentapeptide Carboxypeptidase/biosynthesis/chemistry/metabolism, Penicillin Resistance, Penicillin-Binding Proteins, Penicillins/metabolism, *Peptidyl Transferases, Plasmids, Polymerase Chain Reaction, Protein Structure, Secondary, Restriction Mapping, Sequence Homology, Amino Acid, Species Specificity	Pathogenicity
Genetics	9158761	Intrinsic penicillin resistance in enterococci.	Fontana R, Ligozzi M, Pittaluga F, Satta G	Microb Drug Resist	10.1089/mdr.1996.2.209	1996	Amino Acid Sequence, Bacterial Proteins, Base Sequence, Carrier Proteins/biosynthesis/genetics, Enterococcus/drug effects/genetics, Hexosyltransferases, Molecular Sequence Data, Muramoylpentapeptide Carboxypeptidase/biosynthesis/genetics, Penicillin Resistance/genetics, Penicillin-Binding Proteins, Peptidyl Transferases	Pathogenicity
Metabolism	9163531	Structural feature of the major but not cytokine-inducing molecular species of lipoteichoic acid.	Hashimoto M, Yasuoka J, Suda Y, Takada H, Yoshida T, Kotani S, Kusumoto S	J Biochem	10.1093/oxfordjournals.jbchem.a021653	1997	Alkaline Phosphatase/chemistry/metabolism, Chemical Fractionation, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange/methods, Chromatography, Liquid/methods, Cytokines/drug effects, Enterococcus/chemistry, Fatty Acids/analysis/chemistry, Glucose/analysis, Glycerol/analysis, Glycolipids/chemistry, Hydrolysis, Lipopolysaccharides/chemistry/metabolism/pharmacology, Magnetic Resonance Spectroscopy, Molecular Structure, Structure-Activity Relationship, Teichoic Acids/chemistry/metabolism/*pharmacology	Pathogenicity
Pathogenicity	9258941	Synergy and mechanism of interaction between pefloxacin and penicillin G against enterococci.	Grossato A, Fontana R	New Microbiol		1997	4-Quinolones, Anti-Infective Agents/pharmacology, Bacterial Proteins, Carrier Proteins/analysis, Drug Synergism, Enterococcus/drug effects, Enterococcus faecium/chemistry/drug effects, Fluoroquinolones, Hexosyltransferases, Microbial Sensitivity Tests, Muramoylpentapeptide Carboxypeptidase/analysis, Penicillin G/pharmacology, Penicillin Resistance, Penicillin-Binding Proteins, Penicillins/pharmacology, Peptidyl Transferases, Quinolones/pharmacology
Pathogenicity	9435058	Anaerobic killing of oral streptococci by reduced, transition metal cations.	Dunning JC, Ma Y, Marquis RE	Appl Environ Microbiol	10.1128/AEM.64.1.27-33.1998	1998	Actinomyces/drug effects, Adenosine Triphosphatases/drug effects, Anaerobiosis, Cations/toxicity, Cell Membrane/metabolism, Copper/toxicity, Enterococcus/drug effects, Escherichia coli/drug effects, FMN Reductase, Ferricyanides/pharmacology, Ferrocyanides/pharmacology, Ferrous Compounds/toxicity, Glycolysis/drug effects, Hydrogen Peroxide/metabolism/toxicity, Lactobacillus casei/drug effects, Mouth/microbiology, NADH, NADPH Oxidoreductases/metabolism, Oxygen/metabolism, Streptococcus/*drug effects/enzymology/metabolism, Thiocyanates/pharmacology, Uric Acid/pharmacology	Metabolism
Genetics	9561745	Characterization of new insertion-like sequences of Enterococcus hirae and their dissemination among clinical Enterococcus faecium isolates.	Sechi LA, Franklin R, Dupre I, Zanetti S, Fadda G, Daneo-Moore L	FEMS Microbiol Lett	10.1111/j.1574-6968.1998.tb12944.x	1998	Base Sequence, DNA Fingerprinting, Enterococcus/classification/genetics, Enterococcus faecium/genetics, Molecular Sequence Data, Repetitive Sequences, Nucleic Acid	Phylogeny
Metabolism	9733699	The Na+-responsive ntp operon is indispensable for homeostatis of K+ and Na+ in Enterococcus hirae at limited proton potential.	Kawano M, Igarashi K, Kakinuma Y	J Bacteriol	10.1128/JB.180.18.4942-4945.1998	1998	Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology, Enterococcus/genetics/metabolism, Homeostasis, Operon, Potassium/metabolism, Sodium/*metabolism
Enzymology	9770293	The PBP 5 synthesis repressor (psr) gene of Enterococcus hirae ATCC 9790 is substantially longer than previously reported.	Massidda O, Dardenne O, Whalen MB, Zorzi W, Coyette J, Shockman GD, Daneo-Moore L	FEMS Microbiol Lett	10.1111/j.1574-6968.1998.tb13912.x	1998	Amino Acid Sequence, Bacterial Proteins/chemistry/genetics, Base Sequence, Cloning, Molecular, Enterococcus/genetics, Escherichia coli/genetics, Genes, Bacterial, Molecular Sequence Data, Repressor Proteins/chemistry/genetics, Sequence Analysis, DNA	Genetics
Pathogenicity	9879919	A lipoteichoic acid fraction of Enterococcus hirae activates cultured human monocytic cells via a CD14-independent pathway to promote cytokine production, and the activity is inhibited by serum components.	Arakaki R, Sugawara S, Nakashima H, Kotani S, Takada H	FEMS Immunol Med Microbiol	10.1111/j.1574-695X.1998.tb01217.x	1998	Cell Line, Cells, Cultured, Cytokines/biosynthesis, Enterococcus/immunology, Humans, Leukocytes, Mononuclear/cytology/immunology, Lipopolysaccharide Receptors/immunology, Lipopolysaccharides/immunology/isolation & purification, Monocytes/cytology/immunology, Teichoic Acids/immunology/isolation & purification	Enzymology
Metabolism	10380629	Potassium/proton antiport system is dispensable for growth of Enterococcus hirae at low pH.	Kakinuma Y, Yasumura K, Igarashi K	Biosci Biotechnol Biochem	10.1271/bbb.63.875	1999	Antiporters/metabolism, Culture Media, Enterococcus/growth & development/metabolism, Hydrogen-Ion Concentration, Potassium/*metabolism, Potassium-Hydrogen Antiporters, Protons	Cultivation
Phylogeny	10596896	A novel cytokine-inducing glycolipid isolated from the lipoteichoic acid fraction of Enterococcus hirae ATCC 9790: a fundamental structure of the hydrophilic part.	Hashimoto M, Imamura Y, Yasuoka J, Kotani S, Kusumoto S, Suda Y	Glycoconj J	10.1023/a:1007076304254	1999	Carbohydrate Sequence, Enterococcus/chemistry, Glycolipids/chemistry/isolation & purification/pharmacology, Interleukin-6/blood/metabolism, Lipopolysaccharides/chemistry, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Sequence Data, Teichoic Acids/*chemistry	Genetics
Metabolism	10762252	Evidence for Na(+) influx via the NtpJ protein of the KtrII K(+) uptake system in Enterococcus hirae.	Kawano M, Abuki R, Igarashi K, Kakinuma Y	J Bacteriol	10.1128/JB.182.9.2507-2512.2000	2000	Adenosine Triphosphatases/genetics/metabolism, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Carrier Proteins/genetics/metabolism, Cation Transport Proteins, Cell Membrane Permeability/drug effects, Cell Polarity/drug effects, Enterococcus/drug effects/enzymology/genetics/growth & development, Hydrogen-Ion Concentration, Ionophores/pharmacology, Membrane Potentials/drug effects, Membrane Proteins/genetics/metabolism, Potassium/metabolism, Proton-Translocating ATPases/genetics/metabolism, Sodium/metabolism, *Vacuolar Proton-Translocating ATPases, Valinomycin/pharmacology	Pathogenicity
Pathogenicity	10873580	Cytokine-inducing macromolecular glycolipids from Enterococcus hirae: improved method for separation and analysis of its effects on cellular activation.	Hashimoto M, Imamura Y, Morichika T, Arimoto K, Takeuchi O, Takeda K, Akira S, Aoyama K, Tamura T, Kotani S, Suda Y, Kusumoto S	Biochem Biophys Res Commun	10.1006/bbrc.2000.2921	2000	Animals, Antibodies, Monoclonal/immunology/pharmacology, Calcitriol/pharmacology, Cell Differentiation/drug effects, Cells, Cultured, Cytokines/biosynthesis, Drosophila Proteins, Enterococcus/chemistry, Glycolipids/isolation & purification/pharmacology, Humans, Interleukin-18/biosynthesis, Interleukin-6/biosynthesis, Lipopolysaccharide Receptors/immunology/metabolism, Lipopolysaccharides/pharmacology, Macrophages/cytology/drug effects/metabolism, Membrane Glycoproteins/deficiency/genetics/physiology, Mice, Mice, Knockout, Receptors, Cell Surface/deficiency/genetics/physiology, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptors, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha/biosynthesis, Up-Regulation/drug effects	Metabolism
Pathogenicity	12455613	Bactericidal effect of gentamicin-induced membrane vesicles derived from Pseudomonas aeruginosa PAO1 on gram-positive bacteria.	MacDonald KL, Beveridge TJ	Can J Microbiol	10.1139/w02-077	2002	Anti-Bacterial Agents/pharmacology, Bacteriolysis, Gentamicins/pharmacology, Gram-Positive Bacteria/chemistry/drug effects, Hydrophobic and Hydrophilic Interactions, Microbial Sensitivity Tests, Microscopy, Electron, N-Acetylmuramoyl-L-alanine Amidase/metabolism, Peptidoglycan/analysis, Pseudomonas aeruginosa/drug effects/growth & development, Surface Properties, Transport Vesicles/drug effects/physiology	Metabolism
Metabolism	14526002	Redefining the role of psr in beta-lactam resistance and cell autolysis of Enterococcus hirae.	Sapunaric F, Franssen C, Stefanic P, Amoroso A, Dardenne O, Coyette J	J Bacteriol	10.1128/JB.185.20.5925-5935.2003	2003	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Bacteriolysis, Base Sequence, Carrier Proteins/genetics/metabolism, Enterococcus/drug effects/genetics/growth & development/physiology, Gene Expression Regulation, Bacterial, Hexosyltransferases/genetics/metabolism, Microbial Sensitivity Tests, Molecular Sequence Data, Muramoylpentapeptide Carboxypeptidase/genetics/metabolism, Mutation, Penicillin-Binding Proteins, Peptidyl Transferases/genetics/metabolism, Recombination, Genetic, Repressor Proteins/genetics/metabolism, Sequence Analysis, DNA, *beta-Lactam Resistance	Genetics
Enzymology	15895735	Antimicrobial activity of nisin adsorbed to surfaces commonly used in the food industry.	Guerra NP, Araujo AB, Barrera AM, Agrasar AT, Macias CL, Carballo J, Pastrana L	J Food Prot	10.4315/0362-028x-68.5.1012	2005	Adsorption, Anti-Bacterial Agents/pharmacokinetics, Bacterial Adhesion, Equipment Contamination, Food Contamination/analysis/prevention & control, Food-Processing Industry, Listeria monocytogenes/growth & development/physiology, Nisin/pharmacokinetics, Polyethylene Terephthalates/chemistry, Rubber/chemistry, Stainless Steel/chemistry, Temperature, Time Factors
Biotechnology	16191708	Reproduction of sepsis and endocarditis by experimental infection of chickens with Streptococcus gallinaceus and Enterococcus hirae.	Chadfield MS, Bojesen AM, Christensen JP, Juul-Hansen J, Nielsen SS, Bisgaard M	Avian Pathol	10.1080/03079450500112252	2005	Animals, Chickens, Endocarditis, Bacterial/microbiology/pathology/veterinary, Enterococcus/pathogenicity, Gram-Positive Bacterial Infections/microbiology/pathology/veterinary, Heart Valves/microbiology/pathology, Liver/microbiology/pathology, Poultry Diseases/microbiology/pathology, Sepsis/microbiology/pathology/veterinary, Spleen/microbiology/pathology, Streptococcus/pathogenicity
Cultivation	16212060	[Membrane proton conductivity and energy-dependent fluxes of hydrogen ions in bacteria Enterococcus hirae grown in media with different pH values].		Biofizika		2005	Culture Media, Electric Conductivity, Energy Metabolism/physiology, Enterococcus/enzymology/genetics, Hydrogen-Ion Concentration, Membrane Potentials/physiology, Mutation, Proton-Translocating ATPases/genetics/metabolism, *Protons	Metabolism
Metabolism	16808350	[Growth and proton-potassium exchange in Enterococcus hirae: protonophore effect and the role of oxidation-reduction potential].	Poladian A, Kirakosian G, Trchunian A	Biofizika		2006	Anaerobiosis, Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology, Dithiothreitol/pharmacology, Enterococcus/drug effects/growth & development/metabolism, Fermentation, Ferricyanides/pharmacology, Glucose/metabolism, Hydrogen/metabolism, Hydrogen-Ion Concentration, Ion Transport, Ionophores/pharmacology, Oxidants/pharmacology, Oxidation-Reduction, Potassium/metabolism, Protons	Pathogenicity
Genetics	17920212	Mutational and biochemical analyses of the endolysin Lys(gaY) encoded by the Lactobacillus gasseri JCM 1131T phage phi gaY.	Sugahara K, Yokoi KJ, Nakamura Y, Nishino T, Yamakawa A, Taketo A, Kodaira K	Gene	10.1016/j.gene.2007.08.023	2007	Amino Acid Sequence, Bacillus Phages/enzymology/genetics, DNA Mutational Analysis, Endopeptidases/chemistry/genetics/metabolism, Lactobacillus/virology, Molecular Sequence Data, Protein Structure, Tertiary	Enzymology
Pathogenicity	18298454	Cell wall fraction of Enterococcus hirae ameliorates TNF-alpha-induced barrier impairment in the human epithelial tight junction.	Miyauchi E, Morita H, Okuda J, Sashihara T, Shimizu M, Tanabe S	Lett Appl Microbiol	10.1111/j.1472-765X.2008.02332.x	2008	Caco-2 Cells, Cell Wall/chemistry/immunology, Enterococcus/chemistry/immunology, Epithelial Cells/drug effects/microbiology, Humans, Interleukin-8/biosynthesis, Lipopeptides, Lipopolysaccharides/immunology/isolation & purification, Membrane Proteins/biosynthesis, Myosin-Light-Chain Kinase/biosynthesis, Peptides/immunology, Phosphoproteins/biosynthesis, Teichoic Acids/immunology/isolation & purification, Tight Junctions/drug effects/microbiology, Tumor Necrosis Factor-alpha/*immunology, Zonula Occludens-1 Protein	Enzymology
Phylogeny	18599707	Enterococcus thailandicus sp. nov., isolated from fermented sausage ('mum') in Thailand.	Tanasupawat S, Sukontasing S, Lee JS	Int J Syst Evol Microbiol	10.1099/ijs.0.65535-0	2008	Enterococcus/classification/genetics/isolation & purification, Fermentation, Food Microbiology, Meat Products/*microbiology, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, 16S/genetics, Species Specificity, Thailand	Biotechnology
	18954011	[The action of low-intensity extremely high-freguency electromagnetic radiation on growth parameters for bacteria Enterococcus hirae].	Oganian V, Sarkisian A, Tadevosian A, Torchunian A	Biofizika		2008	Dose-Response Relationship, Radiation, Enterococcus/growth & development, Hydrogen-Ion Concentration, Radiation, Nonionizing
Phylogeny	19621635	[C-ring cleavage of isoflavone daidzein by a newly-isolated facultative Enterococcus hirae AUH-HM195 from Crossoptilon mantchuricum feces].	Yu F, Wang S, Li J, Zhang Q, Li C, Wang X	Wei Sheng Wu Xue Bao		2009	Animals, Biotransformation, Chromatography, High Pressure Liquid, Enterococcus/isolation & purification/metabolism, Feces/microbiology, Galliformes/microbiology, Isoflavones/*metabolism, Magnetic Resonance Spectroscopy	Metabolism
Enzymology	19858568	The in-vitro antimicrobial activity of some medicinal plants against beta-lactam-resistant bacteria.	Gangoue-Pieboji J, Eze N, Ngongang Djintchui A, Ngameni B, Tsabang N, Pegnyemb DE, Biyiti L, Ngassam P, Koulla-Shiro S, Galleni M	J Infect Dev Ctries	10.3855/jidc.77	2009	Anti-Bacterial Agents/isolation & purification/pharmacology, Bacteria/drug effects, Microbial Sensitivity Tests/methods, Plant Bark/chemistry, Plant Extracts/isolation & purification/pharmacology, Plant Leaves/chemistry, Plant Stems/chemistry, Plants, Medicinal/chemistry, *beta-Lactam Resistance	Phylogeny
Pathogenicity	20352375	The effects of copper (II) ions on Enterococcus hirae cell growth and the proton-translocating FoF1 ATPase activity.	Vardanyan Z, Trchounian A	Cell Biochem Biophys	10.1007/s12013-010-9078-z	2010	Cell Proliferation/drug effects, Copper/chemistry/pharmacology, Dose-Response Relationship, Drug, Enterococcus/cytology/drug effects/enzymology, Mutation, Nickel/pharmacology, Oxidation-Reduction/drug effects, Potassium/metabolism, Proton-Translocating ATPases/genetics/*metabolism, Protons, Sulfhydryl Compounds/metabolism	Metabolism
Phylogeny	22003038	Enterococcus lactis sp. nov., from Italian raw milk cheeses.	Morandi S, Cremonesi P, Povolo M, Brasca M	Int J Syst Evol Microbiol	10.1099/ijs.0.030825-0	2011	Bacterial Typing Techniques, Cheese/microbiology, DNA, Bacterial/genetics, DNA, Ribosomal Spacer/genetics, Enterococcus/classification/genetics/isolation & purification, Fatty Acids/analysis, Genes, Bacterial, Italy, Molecular Sequence Data, Phenotype, *Phylogeny, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNA	Genetics
Pathogenicity	22166211	Fe(III) and Fe(II) ions different effects on Enterococcus hirae cell growth and membrane-associated ATPase activity.	Vardanyan Z, Trchounian A	Biochem Biophys Res Commun	10.1016/j.bbrc.2011.11.159	2011	Bacterial Proton-Translocating ATPases/antagonists & inhibitors/metabolism, Cell Membrane/enzymology, Cell Proliferation/drug effects, Dicyclohexylcarbodiimide/pharmacology, Enterococcus/drug effects/growth & development, Ions/pharmacology, Iron/*pharmacology	Metabolism
Metabolism	22288948	Electromagnetic irradiation of Enterococcus hirae at low-intensity 51.8- and 53.0-GHz frequencies: changes in bacterial cell membrane properties and enhanced antibiotics effects.	Torgomyan H, Ohanyan V, Blbulyan S, Kalantaryan V, Trchounian A	FEMS Microbiol Lett	10.1111/j.1574-6968.2012.02512.x	2012	Adenosine Triphosphatases/metabolism, Anti-Bacterial Agents/pharmacology, Ceftriaxone/pharmacology, Cell Membrane/enzymology/radiation effects, Dicyclohexylcarbodiimide/pharmacology, Electromagnetic Radiation, Enterococcus/drug effects/metabolism/*radiation effects, Ion Transport/drug effects/radiation effects, Kanamycin/pharmacology	Pathogenicity
Genetics	22933757	Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis.	Gaechter T, Wunderlin C, Schmidheini T, Solioz M	J Bacteriol	10.1128/JB.01075-12	2012	Copper/metabolism, DNA, Bacterial/chemistry/genetics, Energy Metabolism, Enterococcus faecalis/genetics/physiology, Genome, Bacterial, Homeostasis, Ion Transport, Molecular Sequence Data, Plasmids, *Sequence Analysis, DNA	Metabolism
Metabolism	23712873	The effects of manganese (II) but not nickel (II) ions on Enterococcus hirae cell growth, redox potential decrease, and proton-coupled membrane transport.	Vardanyan Z, Trchounian A	Cell Biochem Biophys	10.1007/s12013-013-9662-0	2013	Dicyclohexylcarbodiimide/pharmacology, Enterococcus/drug effects/growth & development/metabolism, Ion Transport/drug effects, Ions/chemistry, Manganese/chemistry/toxicity, Nickel/chemistry/*toxicity, Oxidation-Reduction, Potassium/chemistry/metabolism, Proton-Translocating ATPases/antagonists & inhibitors/metabolism, Protons	Pathogenicity
Metabolism	24455887	[Changes in ion transport through membranes, ATPase activity and antibiotics effects in Enterococcus hirae after low intensity electromagnetic irradiation of 51,8 and 53,0 GHz frequencies].	Torgomian E, Oganian V, Blbulian C, Trchunian A	Biofizika		2013	Ampicillin/pharmacology, Anaerobiosis, Anti-Bacterial Agents/pharmacology, Cations, Monovalent, Ceftriaxone/pharmacology, Cell Membrane/drug effects/metabolism/radiation effects, Dicyclohexylcarbodiimide/pharmacology, Electromagnetic Radiation, Enterococcus/drug effects/growth & development/metabolism/radiation effects, Fermentation, Glucose/metabolism, Hydrogen-Ion Concentration, Ion Transport/drug effects/radiation effects, Kanamycin/pharmacology, Microbial Sensitivity Tests, Potassium/metabolism, Proton-Translocating ATPases/antagonists & inhibitors/metabolism, Protons	Pathogenicity
Metabolism	25662243	Cu(II), Fe(III) and Mn(II) combinations as environmental stress factors have distinguishing effects on Enterococcus hirae.	Vardanyan Z, Trchounian A	J Environ Sci (China)	10.1016/j.jes.2014.06.043	2014	Adenosine Triphosphatases/genetics/metabolism, Bacterial Proteins/genetics/metabolism, Copper/toxicity, Enterococcus/drug effects/genetics/metabolism, Environmental Pollutants/*toxicity, Ferric Compounds/toxicity, Manganese Compounds/metabolism	Stress
Pathogenicity	25702162	Improved in vitro assay for determining the mucin adherence of bacteria sensitive to Triton X-100 treatment.	Tsilia V, Van den Abbeele P, Van de Wiele T	Folia Microbiol (Praha)	10.1007/s12223-015-0376-0	2015	Animals, Bacteria/drug effects/growth & development, Bacterial Adhesion/drug effects, Biological Assay, Detergents/pharmacology, Intestinal Mucosa/microbiology, Mucins/chemistry, Octoxynol/pharmacology, Swine
Phylogeny	27260143	Enterococcus Xinjiangensis sp. nov., Isolated from Yogurt of Xinjiang, China.	Ren X, Li M, Guo D	Curr Microbiol	10.1007/s00284-016-1065-1	2016	Bacterial Proteins/genetics/metabolism, Bacterial Typing Techniques, Base Composition, China, DNA, Bacterial/genetics, Enterococcus/classification/genetics/isolation & purification/metabolism, Fermentation, Phylogeny, RNA, Ribosomal, 16S/genetics, Yogurt/microbiology	Metabolism
Metabolism	27729019	Enterococcus hirae LcpA (Psr), a new peptidoglycan-binding protein localized at the division site.	Marechal M, Amoroso A, Morlot C, Vernet T, Coyette J, Joris B	BMC Microbiol	10.1186/s12866-016-0844-y	2016	Amino Acid Sequence, Bacterial Proteins/chemistry/genetics/isolation & purification/metabolism, Base Sequence, Carrier Proteins/chemistry/genetics/isolation & purification/metabolism, Cell Membrane/metabolism, Cell Wall/metabolism, Cloning, Molecular, DNA, Bacterial, Enterococcus hirae/cytology/genetics/metabolism, Escherichia coli/genetics/metabolism, Genes, Bacterial, Peptidoglycan/metabolism, Phosphotransferases/metabolism, Protein Interaction Maps, Recombinant Proteins, Repressor Proteins/chemistry/genetics/isolation & purification/*metabolism, beta-Lactam Resistance	Enzymology
Enzymology	28609553	The distinguishing effects of low-intensity electromagnetic radiation of different extremely high frequencies on Enterococcus hirae: growth rate inhibition and scanning electron microscopy analysis.	Hovnanyan K, Kalantaryan V, Trchounian A	Lett Appl Microbiol	10.1111/lam.12764	2017	Electromagnetic Radiation, Enterococcus hirae/chemistry/growth & development/radiation effects/ultrastructure, Kinetics, Microscopy, Electron, Scanning
Pathogenicity	30706116	Antibacterial effects of iron oxide (Fe3O4) nanoparticles: distinguishing concentration-dependent effects with different bacterial cells growth and membrane-associated mechanisms.	Gabrielyan L, Hovhannisyan A, Gevorgyan V, Ananyan M, Trchounian A	Appl Microbiol Biotechnol	10.1007/s00253-019-09653-x	2019	Anti-Bacterial Agents/pharmacology, Cell Membrane/drug effects, Cell Wall/drug effects, Enterococcus/drug effects, Escherichia coli/drug effects, Ferric Compounds/pharmacology, Metal Nanoparticles/chemistry, Oxidation-Reduction, Reactive Oxygen Species/metabolism, Superoxides/metabolism	Metabolism
Enzymology	31560461	Domestic fowl of ducks, a source of faecal bioactive Enterococcus hirae strains.	Laukova A, Bino E, Scerbova J	Pol J Vet Sci	10.24425/pjvs.2019.129958	2019	Animals, Antibiosis, Ducks/microbiology, Enterococcus hirae/isolation & purification, Feces/microbiology	Phylogeny
	32266590	Silver ion bioreduction in nanoparticles using Artemisia annua L. extract: characterization and application as antibacterial agents.	Aghajanyan A, Gabrielyan L, Schubert R, Trchounian A	AMB Express	10.1186/s13568-020-01002-w	2020
	35989355	Biosynthesis of silver nanoparticles using extracts of Stevia rebaudiana and evaluation of antibacterial activity.	Timotina M, Aghajanyan A, Schubert R, Trchounian K, Gabrielyan L	World J Microbiol Biotechnol	10.1007/s11274-022-03393-3	2022	Anti-Bacterial Agents/chemistry/pharmacology, Bacteria, Escherichia coli, Metal Nanoparticles/chemistry, Microbial Sensitivity Tests, Plant Extracts/chemistry/pharmacology, Silver/chemistry/pharmacology, Stevia

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8584	Curators of the DSMZ	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 20160)	https://www.dsmz.de/collection/catalogue/details/culture/DSM-20160
20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.		10.1099/ijsem.0.004332	List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.		10.1016/j.syapm.2013.11.002	StrainInfo introduces electronic passports for microorganisms.	Syst Appl Microbiol. 37: 42-50 2014	24321274
37346	Curators of the CIP		https://brclims.pasteur.fr/brcWeb/souche/detail/1/15800
66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann		https://diaspora-project.de/progress.html#genomes	Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
67770	Curators of the JCM		https://jcm.brc.riken.jp/en/
68381				Automatically annotated from API rID32STR
68382				Automatically annotated from API zym
69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.		https://microbeatlas.org/	MicrobeAtlas 1.0 beta
69480	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann		https://diaspora-project.de/progress.html#genomes	Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
69481	Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch		10.21203/rs.3.rs-2527258/v1	Predictions based on the model GenomeNet Sporulation v. 1
74805	Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.		10.60712/SI-ID91205.1	StrainInfo: A central database for resolving microbial strain identifiers
119908	Curators of the CIP	Collection of Institut Pasteur (CIP 53.48)	https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%2053.48