Strain identifier

BacDive ID: 5137

Type strain: No

Species: Serratia marcescens

Strain history: CIP <- 1993, ATCC <- F.D.A., USA: strain PCI 1107 <- Millipore Filter Corp., US <- Fort Detrick, USA

NCBI tax ID(s): 615 (species)

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General

@ref: 840

BacDive-ID: 5137

DSM-Number: 1636

keywords: Bacteria, facultative anaerobe, mesophilic, Gram-negative, rod-shaped, human pathogen

description: Serratia marcescens DSM 1636 is a facultative anaerobe, mesophilic, Gram-negative human pathogen that was isolated from Unknown source.

NCBI tax id

  • NCBI tax id: 615
  • Matching level: species

strain history

@refhistory
840<- ATCC; ATCC 14756 <- U.S. Food and Drug Administration (FDA), Washington, D.C., USA; PCI 1107 <- Millipore Filter Corp.; <- Fort Derrick;
120783CIP <- 1993, ATCC <- F.D.A., USA: strain PCI 1107 <- Millipore Filter Corp., US <- Fort Detrick, USA

doi: 10.13145/bacdive5137.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/pseudomonadota
  • domain: Bacteria
  • phylum: Pseudomonadota
  • class: Gammaproteobacteria
  • order: Enterobacterales
  • family: Yersiniaceae
  • genus: Serratia
  • species: Serratia marcescens
  • full scientific name: Serratia marcescens Bizio 1823 (Approved Lists 1980)

  • synonyms

    • @ref: 20215
    • synonym: Serratia marcescens subsp. sakuensis

@ref: 840

domain: Bacteria

phylum: Proteobacteria

class: Gammaproteobacteria

order: Enterobacteriales, not validated

family: Yersiniaceae

genus: Serratia

species: Serratia marcescens

full scientific name: Serratia marcescens Bizio 1823

type strain: no

Morphology

cell morphology

  • @ref: 120783
  • gram stain: negative
  • cell shape: rod-shaped

multimedia

  • @ref: 840
  • multimedia content: https://www.dsmz.de/microorganisms/photos/DSM_1636.jpg
  • intellectual property rights: © Leibniz-Institut DSMZ

Culture and growth conditions

culture medium

@refnamegrowthcompositionlink
35126MEDIUM 3 - Columbia agaryesColumbia agar (39.000 g);distilled water (1000.000 ml)
840TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)yesName: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled waterhttps://mediadive.dsmz.de/medium/92
840COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)yesName: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar basehttps://mediadive.dsmz.de/medium/693
120783CIP Medium 72yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=72
120783CIP Medium 3yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=3

culture temp

@refgrowthtypetemperaturerange
840positivegrowth28mesophilic
35126positivegrowth30mesophilic
120783positivegrowth10-41
120783nogrowth5psychrophilic

Physiology and metabolism

oxygen tolerance

  • @ref: 120783
  • oxygen tolerance: facultative anaerobe

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
6837124265gluconate-builds acid from
6837118403L-arabitol-builds acid from
6837118333D-arabitol-builds acid from
6837118287L-fucose-builds acid from
6837128847D-fucose-builds acid from
6837116443D-tagatose-builds acid from
6837162318D-lyxose+builds acid from
6837132528turanose-builds acid from
6837128066gentiobiose-builds acid from
6837117151xylitol+builds acid from
6837128087glycogen-builds acid from
6837128017starch+builds acid from
6837116634raffinose-builds acid from
683716731melezitose-builds acid from
6837115443inulin-builds acid from
6837127082trehalose+builds acid from
6837117992sucrose+builds acid from
6837128053melibiose-builds acid from
6837117306maltose+builds acid from
6837117057cellobiose-builds acid from
6837117814salicin+builds acid from
683714853esculin+builds acid from
6837118305arbutin+builds acid from
6837127613amygdalin-builds acid from
6837159640N-acetylglucosamine+builds acid from
68371320061methyl alpha-D-glucopyranoside-builds acid from
6837143943methyl alpha-D-mannoside-builds acid from
6837117924D-sorbitol+builds acid from
6837116899D-mannitol+builds acid from
6837117268myo-inositol+builds acid from
6837116813galactitol-builds acid from
6837162345L-rhamnose-builds acid from
6837117266L-sorbose-builds acid from
6837116024D-mannose+builds acid from
6837115824D-fructose+builds acid from
6837117634D-glucose+builds acid from
6837112936D-galactose+builds acid from
6837174863methyl beta-D-xylopyranoside-builds acid from
6837115963ribitol+builds acid from
6837165328L-xylose-builds acid from
6837165327D-xylose-builds acid from
6837116988D-ribose+builds acid from
6837130849L-arabinose-builds acid from
6837117108D-arabinose-builds acid from
6837117113erythritol-builds acid from
6837117754glycerol+builds acid from
6836830849L-arabinose+fermentation
6836827613amygdalin+fermentation
6836828053melibiose+fermentation
6836817992sucrose+fermentation
6836862345L-rhamnose-fermentation
6836830911sorbitol+fermentation
6836817268myo-inositol+fermentation
6836816899D-mannitol+fermentation
683685291gelatin+hydrolysis
6836827897tryptophan-energy source
6836816199urea-hydrolysis
6836816947citrate+assimilation
6836818257ornithine+degradation
6836829016arginine-hydrolysis
12078329864mannitol+fermentation
12078316947citrate+carbon source
12078317234glucose+fermentation
12078317716lactose-fermentation
12078317632nitrate+reduction
12078316301nitrite-reduction
12078315792malonate-assimilation
120783132112sodium thiosulfate-builds gas from
6837418257ornithine+degradation
6837429016arginine-hydrolysis
6837425094lysine+degradation
6837416199urea-hydrolysis
6837418403L-arabitol-builds acid from
6837418024D-galacturonic acid-builds acid from
68374Potassium 5-ketogluconate-builds acid from
6837416899D-mannitol+builds acid from
6837417306maltose-builds acid from
6837415963ribitol+builds acid from
6837418394palatinose-builds acid from
6837415792malonate-assimilation
6837427897tryptophan-energy source
6837417634D-glucose+builds acid from
6837417992sucrose+builds acid from
6837430849L-arabinose-builds acid from
6837418333D-arabitol-builds acid from
6837427082trehalose+builds acid from
6837462345L-rhamnose-builds acid from
6837417268myo-inositol+builds acid from
6837417057cellobiose-builds acid from
6837430911sorbitol+builds acid from

antibiotic resistance

  • @ref: 120783
  • metabolite: 0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)
  • is antibiotic: yes
  • is sensitive: yes
  • is resistant: no

metabolite production

@refChebi-IDmetaboliteproduction
6837435581indoleno
6836815688acetoinyes
6836835581indoleno
6836816136hydrogen sulfideno
12078335581indoleno

metabolite tests

@refChebi-IDmetaboliteindole testvoges-proskauer-testmethylred-test
6837435581indole-
6836815688acetoin+
6836835581indole-
12078315688acetoin+
12078317234glucose-

enzymes

@refvalueactivityec
68382alpha-fucosidase-3.2.1.51
68382alpha-mannosidase-3.2.1.24
68382N-acetyl-beta-glucosaminidase+3.2.1.52
68382beta-glucosidase+3.2.1.21
68382alpha-glucosidase+3.2.1.20
68382beta-glucuronidase-3.2.1.31
68382beta-galactosidase+3.2.1.23
68382alpha-galactosidase-3.2.1.22
68382naphthol-AS-BI-phosphohydrolase+
68382acid phosphatase+3.1.3.2
68382alpha-chymotrypsin-3.4.21.1
68382trypsin+3.4.21.4
68382cystine arylamidase+3.4.11.3
68382valine arylamidase+
68382leucine arylamidase+3.4.11.1
68382lipase (C 14)+
68382esterase lipase (C 8)+
68382esterase (C 4)+
68382alkaline phosphatase+3.1.3.1
68374L-aspartate arylamidase+3.4.11.21
68374alpha-maltosidase-
68374alpha-galactosidase-3.2.1.22
68374alpha-glucosidase-3.2.1.20
68374beta-galactosidase+3.2.1.23
68374N-acetyl-beta-glucosaminidase+3.2.1.52
68374beta-glucuronidase-3.2.1.31
68374beta-glucosidase+3.2.1.21
68374lipase+
68374urease-3.5.1.5
68374lysine decarboxylase+4.1.1.18
68374arginine dihydrolase-3.5.3.6
68374ornithine decarboxylase+4.1.1.17
68368cytochrome oxidase-1.9.3.1
68368gelatinase+
68368tryptophan deaminase-4.1.99.1
68368urease-3.5.1.5
68368ornithine decarboxylase+4.1.1.17
68368arginine dihydrolase-3.5.3.6
68368beta-galactosidase+3.2.1.23
120783oxidase-
120783beta-galactosidase+3.2.1.23
120783alcohol dehydrogenase-1.1.1.1
120783catalase+1.11.1.6
120783lysine decarboxylase+4.1.1.18
120783ornithine decarboxylase+4.1.1.17
120783phenylalanine ammonia-lyase-4.3.1.24
120783tryptophan deaminase-
120783urease-3.5.1.5

API zym

@refControlAlkaline phosphataseEsteraseEsterase LipaseLipaseLeucine arylamidaseValine arylamidaseCystine arylamidaseTrypsinalpha- ChymotrypsinAcid phosphataseNaphthol-AS-BI-phosphohydrolasealpha- Galactosidasebeta- Galactosidasebeta- Glucuronidasealpha- Glucosidasebeta- GlucosidaseN-acetyl-beta- glucosaminidasealpha- Mannosidasealpha- Fucosidase
120783-++++++++-++-+-+++--

API 20E

@refONPGADH ArgLDC LysODCCITH2SURETDA TrpINDVPGELGLUMANINOSorRHASACMELAMYARAOX
840+--++----++++++-++++-
840+-+++----++-+++-++++-

API 50CHac

@refGLYERYDARALARARIBDXYLLXYLADOMDXGALGLUFRUMNESBERHADULINOMANSORMDMMDGNAGAMYARBESCSALCELMALLACMELSACTREINUMLZRAFAMDGLYGXLTGENTURLYXTAGDFUCLFUCDARLLARLGNT2KG5KG
120783+---+--+-++++---+++--+-+++-++/--++---+-+--+------+/-+/-

API ID32E

@refODCADH ArgLDC LysURELARLGAT5KGLIPRPbeta GLUMANMALADOPLEbeta GURMNTINDbeta NAGbeta GALGLUSACLARADARLalpha GLUalpha GALTRERHAINOCELSORalphaMALAspA
57164+-+----+-++-+----++++----+-+-+-+

API biotype100

@refGLUFRUGALTREMNESBEMELSACRAFMTEMALLACLTEMbGaMaGaCELGENMbGuESCRIBARAXYLPLERHAFUCMLZDARLLARLXLTDULTAGGLYINOMANMTLTURSORADOHBGLYXERYMDG3MDGSATMUCLTATDTATMTATDMLTLMLTCATETATETTECITGRTGAT2KG5KGTRYNAGGNTPACPATpOBEQATGTEmOBEBATPPATCMTTGEBETPCEABTHINLATCAPCYTHISSUCFUMGREGYTAVTETNTTNGLNITA3OBUAPTGTTPRODALALALASERMNTPROPTYR2KT
120783+++++--+-++--+---+++----+--++--+++--++-++--------+++-+++++-+++++-+------++-+++-++-+---+--++++++-++-

Isolation, sampling and environmental information

isolation

  • @ref: 120783
  • sample type: Unknown source
  • isolation date: 1961

Safety information

risk assessment

@refpathogenicity humanpathogenicity animalbiosafety levelbiosafety level comment
840yesyes2Risk group (German classification)
1207831Risk group (French classification)

External links

@ref: 840

culture collection no.: DSM 1636, ATCC 14756, CCUG 46356, CIP 103716, PCI 1107

straininfo link

  • @ref: 74629
  • straininfo: 7464

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Enzymology9449286Cloning and nucleotide sequence of the DNA gyrase gyrA gene from Serratia marcescens and characterization of mutations in gyrA of quinolone-resistant clinical isolates.Kim JH, Cho EH, Kim KS, Kim HY, Kim YMAntimicrob Agents Chemother10.1128/AAC.42.1.19019984-Quinolones, Amino Acid Sequence, Anti-Infective Agents/therapeutic use, Base Sequence, Cloning, Molecular, DNA Gyrase, DNA Topoisomerases, Type II/*genetics, Drug Resistance, Microbial/genetics, Humans, Molecular Sequence Data, Point Mutation, Serratia Infections/drug therapy/enzymology/*genetics, Serratia marcescens/drug effects/enzymology/*genetics, Topoisomerase II InhibitorsPathogenicity
Pathogenicity21705110Bacterial reduction of alcohol-based liquid and gel products on hands soiled with blood.Kawagoe JY, Graziano KU, Martino MD, Siqueira I, Correa LAm J Infect Control10.1016/j.ajic.2010.12.0182011Adolescent, Adult, Alcohols/administration & dosage/*pharmacology, Bacterial Load, Blood/*microbiology, Disinfectants/administration & dosage/*metabolism, Female, Hand/*microbiology, Hand Disinfection/*methods, Humans, Male, Middle Aged, Serratia marcescens/*drug effects/*isolation & purification, Young AdultMetabolism
Pathogenicity22003004Quest for a realistic in vivo test method for antimicrobial hand-rub agents: introduction of a low-volume hand contamination procedure.Macinga DR, Beausoleil CM, Campbell E, Mulberry G, Brady A, Edmonds SL, Arbogast JWAppl Environ Microbiol10.1128/AEM.06134-112011*Bacterial Load, Disinfectants/*administration & dosage, Dose-Response Relationship, Drug, Hand/*microbiology, Hand Disinfection/*methods/*standards, Humans, Serratia marcescens/*drug effects/*isolation & purification, Treatment OutcomeEnzymology
23797557Effectiveness of disinfection with alcohol 70% (w/v) of contaminated surfaces not previously cleaned.Graziano MU, Graziano KU, Pinto FM, Bruna CQ, de Souza RQ, Lascala CARev Lat Am Enfermagem10.1590/s0104-116920130002000202013Disinfection/*standards, Equipment Contamination/*prevention & control, *Ethanol, Single-Blind Method
Pathogenicity23893220[Comparison of antimicrobial effect of alcohol gel according to the amount and drying time in health personnel hand hygiene].Ji YJ, Jeong JSJ Korean Acad Nurs10.4040/jkan.2013.43.3.3052013Adolescent, Adult, Anti-Infective Agents, Local/*pharmacology, Cross-Over Studies, Ethanol/chemistry/*pharmacology, Gels/*chemistry, Hand Hygiene/*methods, Humans, Middle Aged, Serratia marcescens/*drug effects, Time Factors, Young Adult
Pathogenicity27930849Searching for a potential antibacterial lead structure against bacterial biofilms among new naphthoquinone compounds.Moreira CS, Silva AC, Novais JS, Sa Figueiredo AM, Ferreira VF, da Rocha DR, Castro HCJ Appl Microbiol10.1111/jam.133692017Anti-Bacterial Agents/*pharmacology, Biofilms/*drug effects, Enterobacter cloacae, Enterococcus faecalis/drug effects, Escherichia coli/drug effects, Gram-Positive Bacteria/drug effects, Humans, Klebsiella pneumoniae/drug effects, Methicillin-Resistant Staphylococcus aureus/*drug effects, Microbial Sensitivity Tests, Naphthoquinones/chemistry/*pharmacology, Proteus mirabilis/drug effects, Pseudomonas aeruginosa/drug effects, Staphylococcus/drug effects, Vancomycin
Pathogenicity29180790Vanillic acid from Actinidia deliciosa impedes virulence in Serratia marcescens by affecting S-layer, flagellin and fatty acid biosynthesis proteins.Sethupathy S, Ananthi S, Selvaraj A, Shanmuganathan B, Vigneshwari L, Balamurugan K, Mahalingam S, Pandian SKSci Rep10.1038/s41598-017-16507-x2017Actinidia/*chemistry, Animals, Anti-Bacterial Agents/chemistry/*pharmacology, Bacterial Proteins/metabolism, Biofilms/drug effects, Caenorhabditis elegans/microbiology, Chromatography, Liquid, Dose-Response Relationship, Drug, Fatty Acids/biosynthesis, Flagellin/*metabolism, Mass Spectrometry, Plant Extracts/chemistry/*pharmacology, Proteome, Proteomics/methods, Quorum Sensing/drug effects, Serratia marcescens/*drug effects/pathogenicity/*physiology, Vanillic Acid/chemistry/*pharmacology, Virulence/*drug effects, Virulence FactorsMetabolism
Pathogenicity29550501Antibacterial naphthoquinone derivatives targeting resistant strain Gram-negative bacteria in biofilms.Novais JS, Moreira CS, Silva ACJA, Loureiro RS, Sa Figueiredo AM, Ferreira VF, Castro HC, da Rocha DRMicrob Pathog10.1016/j.micpath.2018.03.0242018Anti-Bacterial Agents/chemical synthesis/chemistry/*pharmacology/toxicity, Biofilms/*drug effects, Ciprofloxacin/pharmacology, Erythrocytes/drug effects, Gram-Negative Bacteria/*drug effects, Gram-Positive Bacteria/drug effects, Humans, Materials Testing, Microbial Sensitivity Tests, Naphthoquinones/chemical synthesis/chemistry/*pharmacology/toxicity
Pathogenicity31425793Evaluation of rapid colistin susceptibility directly from positive blood cultures using a flow cytometry assay.Fonseca E Silva D, Silva-Dias A, Gomes R, Martins-Oliveira I, Ramos MH, Rodrigues AG, Canton R, Pina-Vaz CInt J Antimicrob Agents10.1016/j.ijantimicag.2019.08.0162019Anti-Bacterial Agents/*pharmacology, Bacteria/*drug effects, Blood Culture, Colistin/*pharmacology, *Drug Resistance, Bacterial, Gram-Negative Bacteria/*drug effects, Humans, Microbial Sensitivity Tests

Reference

@idauthorscataloguedoi/urltitle
840Curators of the DSMZLeibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 1636)https://www.dsmz.de/collection/catalogue/details/culture/DSM-1636
20215Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.10.1099/ijsem.0.004332List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
35126Curators of the CIPhttps://brclims.pasteur.fr/brcWeb/souche/detail/1/15544
57164Curators of the CCUGCulture Collection University of Gothenburg (CCUG) (CCUG 46356)https://www.ccug.se/strain?id=46356
68368Automatically annotated from API 20E
68371Automatically annotated from API 50CH acid
68374Automatically annotated from API ID32E
68382Automatically annotated from API zym
74629Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.10.60712/SI-ID7464.1StrainInfo: A central database for resolving microbial strain identifiers
120783Curators of the CIPCollection of Institut Pasteur (CIP 103716)https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20103716