Archive BacDiveID:10.13145/bacdive2529.20230509.8.1

Strain identifier

BacDive ID: 2529

Type strain:

Species: Clostridium acetobutylicum

Strain Designation: 2291, W

Strain history: IAM 19013 <-- S. Sugama <-- ATCC 824 <-- E. R. Weyer.

NCBI tax ID(s): 272562 (strain), 1488 (species)

For citation purpose refer to the digital object identifier (doi) of the current version.

General

@ref: 449

BacDive-ID: 2529

DSM-Number: 792

keywords: genome sequence, 16S sequence, Bacteria, anaerobe, spore-forming, mesophilic, motile, alcohol production

description: Clostridium acetobutylicum 2291 is an anaerobe, spore-forming, mesophilic bacterium that produces alcohol and was isolated from cornmeal.

NCBI tax id

NCBI tax id	Matching level
272562	strain
1488	species

strain history

@ref	history
449	<- ATCC <- E. R. Weyer, Yale University, Laboratory of General Bacteriology, New Haven, Connecticut, USA (Granulobacter pectinovorum)
67770	IAM 19013 <-- S. Sugama <-- ATCC 824 <-- E. R. Weyer.

doi: 10.13145/bacdive2529.20230509.8.1

Name and taxonomic classification

LPSN

@ref: 20215
description: domain/bacteria
keyword: phylum/bacillota
domain: Bacteria
phylum: Bacillota
class: Clostridia
order: Eubacteriales
family: Clostridiaceae
genus: Clostridium
species: Clostridium acetobutylicum
full scientific name: Clostridium acetobutylicum McCoy et al. 1926 (Approved Lists 1980)

@ref: 449

domain: Bacteria

phylum: Firmicutes

class: Clostridia

order: Clostridiales

family: Clostridiaceae

genus: Clostridium

species: Clostridium acetobutylicum

full scientific name: Clostridium acetobutylicum McCoy et al. 1926 emend. Keis et al. 2001

strain designation: 2291, W

type strain: yes

Morphology

cell morphology

@ref	motility	confidence	gram stain
69480	yes	94.962
69480		100	positive

Culture and growth conditions

culture medium

@ref	name	growth	link	composition
449	CLOSTRIDIUM ACETOBUTYLICUM MEDIUM (DSMZ Medium 411)	yes	https://mediadive.dsmz.de/medium/411	Name: CLOSTRIDIUM ACETOBUTYLICUM MEDIUM (DSMZ Medium 411) Composition: Potato 200.0 g/l D-Glucose 6.0 g/l CaCO3 2.0 g/l L-Cysteine HCl x H2O 0.5 g/l Sodium resazurin 0.0005 g/l Distilled water
449	PY + X MEDIUM (DSMZ Medium 104b)	yes	https://mediadive.dsmz.de/medium/104b	Name: PY + X MEDIUM (DSMZ Medium 104b) Composition: Yeast extract 10.0 g/l D-Glucose 5.0 g/l Trypticase peptone 5.0 g/l Meat peptone 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l KH2PO4 0.04 g/l K2HPO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Sodium resazurin 0.0005 g/l Distilled water

culture temp

@ref	growth	type	temperature	range
449	positive	growth	37	mesophilic
55354	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

oxygen tolerance

@ref	oxygen tolerance	confidence
449	anaerobe
55354	anaerobe
69480	anaerobe	98.973

spore formation

@ref	spore formation	confidence
69481	yes	100
69480	yes	100

compound production

@ref	compound
449	acetone
449	n butanol
449	autobacteriocin
449	acidolysin

observation

@ref: 67770
observation: Assay of p-Aminobenzoic acid

metabolite utilization

@ref	Chebi-ID	metabolite	utilization activity	kind of utilization tested
68380	16199	urea	-	hydrolysis
68380	29016	arginine	-	hydrolysis
68380	16024	D-mannose	+	fermentation
68380	16634	raffinose	-	fermentation
68380	29985	L-glutamate	-	degradation
68380	17632	nitrate	-	reduction
68380	27897	tryptophan	-	energy source

metabolite production

@ref	Chebi-ID	metabolite	production
67770	15347	acetone	yes
67770		butanol	yes
68380	35581	indole	no

metabolite tests

@ref: 68380
Chebi-ID: 35581
metabolite: indole
indole test: -

enzymes

@ref	value	activity	ec
68382	alpha-fucosidase	-	3.2.1.51
68382	alpha-mannosidase	-	3.2.1.24
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52
68382	beta-glucosidase	+	3.2.1.21
68382	alpha-glucosidase	+	3.2.1.20
68382	beta-glucuronidase	-	3.2.1.31
68382	beta-galactosidase	-	3.2.1.23
68382	alpha-galactosidase	-	3.2.1.22
68382	naphthol-AS-BI-phosphohydrolase	-
68382	acid phosphatase	+	3.1.3.2
68382	alpha-chymotrypsin	-	3.4.21.1
68382	trypsin	-	3.4.21.4
68382	cystine arylamidase	-	3.4.11.3
68382	valine arylamidase	-
68382	leucine arylamidase	-	3.4.11.1
68382	lipase (C 14)	-
68382	esterase lipase (C 8)	+
68382	esterase (C 4)	+
68382	alkaline phosphatase	-	3.1.3.1
68380	serine arylamidase	-
68380	glutamyl-glutamate arylamidase	-
68380	histidine arylamidase	-
68380	glycin arylamidase	-
68380	alanine arylamidase	-	3.4.11.2
68380	tyrosine arylamidase	-
68380	pyrrolidonyl arylamidase	-	3.4.19.3
68380	leucine arylamidase	-	3.4.11.1
68380	phenylalanine arylamidase	-
68380	leucyl glycin arylamidase	-	3.4.11.1
68380	proline-arylamidase	-	3.4.11.5
68380	L-arginine arylamidase	-
68380	alkaline phosphatase	-	3.1.3.1
68380	tryptophan deaminase	-	4.1.99.1
68380	alpha-fucosidase	-	3.2.1.51
68380	glutamate decarboxylase	-	4.1.1.15
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52
68380	beta-glucuronidase	-	3.2.1.31
68380	alpha-arabinosidase	-	3.2.1.55
68380	beta-glucosidase	+	3.2.1.21
68380	alpha-glucosidase	+	3.2.1.20
68380	beta-Galactosidase 6-phosphate	+
68380	beta-galactosidase	-	3.2.1.23
68380	alpha-galactosidase	-	3.2.1.22
68380	arginine dihydrolase	-	3.5.3.6
68380	urease	-	3.5.1.5

API zym

@ref	Control	Alkaline phosphatase	Esterase	Esterase Lipase	Lipase	Leucine arylamidase	Valine arylamidase	Cystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
55354	-	-	+	+	-	-	-	-	-	-	+	-	-	-	-	+	+	-	-	-

API rID32A

@ref	URE	ADH Arg	alpha GAL	beta GAL	beta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta NAG	MNE	RAF	GDC	alpha FUC	NIT	IND	PAL	ArgA	ProA	LGA	PheA	LeuA	PyrA	TyrA	AlaA	GlyA	HisA	GGA	SerA
55354	-	-	-	-	+	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

isolation

@ref: 449
sample type: cornmeal

isolation source categories

Cat1	Cat2	Cat3
#Host	#Plants	#Herbaceous plants (Grass,Crops)
#Engineered	#Food production

Safety information

risk assessment

@ref: 449
biosafety level: 1
biosafety level comment: Risk group (German classification)

Sequence information

16S sequences

@ref	description	accession	length	database	NCBI tax ID
20218	Clostridium acetobutylicum ATCC 824 16S ribosomal RNA (rrn) gene, partial sequence	U16166	1411	ena	272562
20218	Clostridium acetobutylicum DSM 792 16S ribosomal RNA (rrn) gene, partial sequence	U17030	554	ena	272562
20218	C.acetobutylicum (ATCC 824, T) 16S rRNA	X78070	1389	ena	272562
67770	Clostridium acetobutylicum gene for 16S ribosomal RNA, partial sequence, strain: JCM 1419	AB595131	1467	ena	1488
67770	16S rRNA [Clostridium acetobutylicum, NCIMB 8052, rRNA, 1411 nt]	S46735	1411	ena	1488

Genome sequences

@ref	description	accession	assembly level	database	NCBI tax ID
66792	Clostridium acetobutylicum ATCC 824	GCA_000008765	complete	ncbi	272562
66792	Clostridium beijerinckii NCIMB 8052	GCA_000016965	complete	ncbi	290402
66792	Clostridium acetobutylicum ATCC 824	272562.61	plasmid	patric	272562
66792	Clostridium acetobutylicum ATCC 824	272562.8	complete	patric	272562
66792	Clostridium beijerinckii NCIMB 8052	290402.41	complete	patric	290402
66792	Clostridium acetobutylicum ATCC 824	637000076	complete	img	272562
66792	Clostridium beijerinckii NCIMB 8052	640753016	complete	img	290402

GC content

@ref	GC-content	method
449	28.0
67770	33.4	high performance liquid chromatography (HPLC)
67770	28	thermal denaturation, midpoint method (Tm)

Genome-based predictions

predictions

trait	prediction	confidence	training_data
spore-forming	yes	100	no
motile	yes	80.208	no
flagellated	yes	70.107	no
gram-positive	yes	80.136	no
anaerobic	yes	96.981	yes
halophile	no	95.572	no
spore-forming	yes	96.728	no
thermophile	no	97.407	yes
glucose-util	yes	90.183	no
aerobic	no	98.04	yes
glucose-ferment	yes	61.374	no

External links

@ref: 449

culture collection no.: DSM 792, ATCC 824, VKM B-1787, CCUG 42182 C, LMG 5710, CECT 508, IFO 13948, JCM 1419, BCRC 10639, CCUG 42182, IAM 19013, KCTC 1790, NBRC 13948, NCIMB 8052, NRRL B-527

straininfo link

@ref: 72063
straininfo: 92208

literature

topic	Pubmed-ID	title	authors	journal	DOI	year	mesh	topic2
Enzymology	1355455	Reconstruction and expression of the autolytic gene from Clostridium acetobutylicum ATCC 824 in Escherichia coli.	Croux C, Garcia JL	FEMS Microbiol Lett	10.1016/0378-1097(92)90730-c	1992	Bacteriolysis, Cloning, Molecular, Clostridium/enzymology/genetics, Cytoplasm/enzymology, Escherichia coli/genetics, Genes, Bacterial, Hydrogen-Ion Concentration, Molecular Weight, N-Acetylmuramoyl-L-alanine Amidase/biosynthesis/*genetics/metabolism, Plasmids	Metabolism
Enzymology	1368230	Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824.	Mermelstein LD, Welker NE, Bennett GN, Papoutsakis ET	Biotechnology (N Y)	10.1038/nbt0292-190	1992	Bacillus subtilis/enzymology/genetics, Carboxy-Lyases/genetics, Cloning, Molecular/methods, Clostridium/enzymology/genetics, DNA, Bacterial/genetics/isolation & purification, Escherichia coli/genetics, Fermentation, Genes, Bacterial, Genetic Vectors, Phosphate Acetyltransferase/genetics, Plasmids, Restriction Mapping	Phylogeny
Enzymology	1385386	Molecular characterization of two Clostridium acetobutylicum ATCC 824 butanol dehydrogenase isozyme genes.	Walter KA, Bennett GN, Papoutsakis ET	J Bacteriol	10.1128/jb.174.22.7149-7158.1992	1992	Alcohol Oxidoreductases/genetics/isolation & purification/metabolism, Amino Acid Sequence, Base Sequence, Blotting, Northern, Cloning, Molecular, Clostridium/enzymology/genetics, DNA, Bacterial/genetics/isolation & purification, Escherichia coli/genetics/growth & development, Genes, Bacterial, Isoenzymes/*genetics/isolation & purification/metabolism, Kinetics, Molecular Sequence Data, Oligonucleotide Probes, Open Reading Frames, Protein Biosynthesis, RNA, Bacterial/genetics/isolation & purification, RNA, Messenger/analysis/metabolism, Recombinant Proteins/isolation & purification/metabolism, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Transcription, Genetic	Phylogeny
Enzymology	1416617	Vector construction, transformation, and gene amplification in Clostridium acetobutylicum ATCC 824.	Lee SY, Mermelstein LD, Bennett GN, Papoutsakis ET	Ann N Y Acad Sci	10.1111/j.1749-6632.1992.tb42572.x	1992	Bacillus subtilis/genetics, Base Sequence, Cloning, Molecular/methods, Clostridium/genetics/metabolism, DNA, Bacterial/genetics/isolation & purification, Enterococcus faecalis/genetics, Escherichia coli/genetics, Fermentation, Gene Amplification, Genetic Techniques, Genetic Vectors, Plasmids, Restriction Mapping, Transformation, Bacterial	Metabolism
Enzymology	1599233	Purification and characterization of an extracellular muramidase of Clostridium acetobutylicum ATCC 824 that acts on non-N-acetylated peptidoglycan.	Croux C, Canard B, Goma G, Soucaille P	Appl Environ Microbiol	10.1128/aem.58.4.1075-1081.1992	1992	Acetylation, Alcohols/pharmacology, Amino Acid Sequence, Carbohydrate Metabolism, Clostridium/enzymology, Hydrogen-Ion Concentration, Kinetics, Metals/pharmacology, Molecular Sequence Data, Muramidase/isolation & purification/metabolism, Peptidoglycan/*metabolism, Sequence Alignment, Substrate Specificity, Temperature	Metabolism
Enzymology	1645127	Autolysis of Clostridium acetobutylicum ATCC 824.	Croux C, Canard B, Goma G, Soucaille P	J Gen Microbiol	10.1099/00221287-138-5-861	1992	Amino Acid Sequence, Amino Acids/pharmacology, Amino Alcohols/pharmacology, Amino Sugars/pharmacology, Autolysis, Cell Division, Cell Wall/enzymology, Chelating Agents/pharmacology, Clostridium/enzymology/physiology, Hot Temperature, Hydrogen-Ion Concentration, Ions, Lipopolysaccharides, Molecular Sequence Data, Mucoproteins/chemistry/isolation & purification, Muramidase/chemistry/isolation & purification, Phospholipids/pharmacology, Sequence Homology, Nucleic Acid, Subcellular Fractions/enzymology, Teichoic Acids/pharmacology	Stress
Enzymology	1685080	Cloning of the Clostridium acetobutylicum ATCC 824 acetyl coenzyme A acetyltransferase (thiolase; EC 2.3.1.9) gene.	Petersen DJ, Bennett GN	Appl Environ Microbiol	10.1128/aem.57.9.2735-2741.1991	1991	Acetyl-CoA C-Acetyltransferase/chemistry/genetics, Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA, Bacterial/chemistry, Escherichia coli/genetics, Genes, Bacterial, Genetic Vectors, Molecular Sequence Data, Recombination, Genetic, Restriction Mapping, Sequence Homology, Nucleic Acid	Genetics
Enzymology	1698349	Regulation and localization of amylolytic enzymes in Clostridium acetobutylicum ATCC 824.	Annous BA, Blaschek HP	Appl Environ Microbiol	10.1128/aem.56.8.2559-2561.1990	1990	Amylases/genetics/metabolism, Clostridium/enzymology/genetics, Cytoplasm/enzymology, Glucose/pharmacology, Histocytochemistry, Intracellular Membranes/enzymology, Starch/pharmacology, Transcription, Genetic/drug effects	Metabolism
Phylogeny	1722664	Isolation and characterization of Clostridium acetobutylicum mutants with enhanced amylolytic activity.	Annous BA, Blaschek HP	Appl Environ Microbiol	10.1128/aem.57.9.2544-2548.1991	1991	Amylases/biosynthesis/isolation & purification, Carbohydrates/pharmacology, Clostridium/enzymology/genetics/growth & development/isolation & purification, *Mutagenesis	Enzymology
Enzymology	1916274	Sequence of the lyc gene encoding the autolytic lysozyme of Clostridium acetobutylicum ATCC824: comparison with other lytic enzymes.	Croux C, Garcia JL	Gene	10.1016/0378-1119(91)90460-s	1991	Amino Acid Sequence, Bacteria/enzymology/genetics, Bacteriophages/enzymology/genetics, Base Sequence, Cloning, Molecular, Clostridium/enzymology/genetics, Genes, Bacterial, Molecular Sequence Data, Muramidase/*genetics, Oligonucleotides, Restriction Mapping, Sequence Homology, Nucleic Acid	Genetics
Enzymology	1999395	Molecular cloning of an alcohol (butanol) dehydrogenase gene cluster from Clostridium acetobutylicum ATCC 824.	Petersen DJ, Welch RW, Rudolph FB, Bennett GN	J Bacteriol	10.1128/jb.173.5.1831-1834.1991	1991	Alcohol Dehydrogenase/genetics, Alcohol Oxidoreductases/genetics/isolation & purification, Chromatography, Ion Exchange, Cloning, Molecular, Clostridium/enzymology/genetics, Electrophoresis, Polyacrylamide Gel, Escherichia coli/genetics, Genes, Bacterial, Isoenzymes/genetics/isolation & purification, Molecular Weight, Multigene Family, Recombinant Proteins/isolation & purification, Restriction Mapping	Phylogeny
Enzymology	2082818	Purification and characterization of acidolysin, an acidic metalloprotease produced by Clostridium acetobutylicum ATCC 824.	Croux C, Paquet V, Goma G, Soucaille P	Appl Environ Microbiol	10.1128/aem.56.12.3634-3642.1990	1990	Amino Acid Sequence, Amino Acids/analysis, Azo Compounds/metabolism, Calcium/analysis, Chromatography, Ion Exchange, Clostridium/enzymology, Collagen/metabolism, Electrophoresis, Polyacrylamide Gel, Enzyme Stability, Hydrogen-Ion Concentration, Hydrolysis, Insulin/metabolism, Isoelectric Point, Metalloendopeptidases/chemistry/isolation & purification/metabolism, Molecular Sequence Data, Molecular Weight, Peptides/metabolism, Renin/metabolism, Spectrophotometry, Atomic, Substrate Specificity, Temperature, Zinc/analysis	Metabolism
Enzymology	2254264	Cloning, sequencing, and molecular analysis of the acetoacetate decarboxylase gene region from Clostridium acetobutylicum.	Gerischer U, Durre P	J Bacteriol	10.1128/jb.172.12.6907-6918.1990	1990	Amino Acid Sequence, Amino Acids/analysis, Base Sequence, Blotting, Southern, Carboxy-Lyases/genetics/isolation & purification/metabolism, Cloning, Molecular, Clostridium/enzymology/genetics, Codon, DNA, Bacterial/genetics, Electrophoresis, Polyacrylamide Gel, Gene Expression Regulation, Bacterial, *Genes, Bacterial, Molecular Sequence Data, Protein Biosynthesis, Protein Conformation, Regulatory Sequences, Nucleic Acid, Restriction Mapping, Transcription, Genetic	Genetics
Enzymology	2268159	Purification of acetoacetate decarboxylase from Clostridium acetobutylicum ATCC 824 and cloning of the acetoacetate decarboxylase gene in Escherichia coli.	Petersen DJ, Bennett GN	Appl Environ Microbiol	10.1128/aem.56.11.3491-3498.1990	1990	Amino Acid Sequence, Base Sequence, Carboxy-Lyases/genetics, Cloning, Molecular, Clostridium/enzymology/genetics, DNA Probes, DNA, Bacterial/genetics, Escherichia coli/genetics, *Genes, Bacterial, Molecular Sequence Data, Restriction Mapping, Sequence Homology, Nucleic Acid	Genetics
Enzymology	2383002	Cloning and expression of Clostridium acetobutylicum ATCC 824 acetoacetyl-coenzyme A:acetate/butyrate:coenzyme A-transferase in Escherichia coli.	Cary JW, Petersen DJ, Papoutsakis ET, Bennett GN	Appl Environ Microbiol	10.1128/aem.56.6.1576-1583.1990	1990	Acetates/metabolism, Amino Acid Sequence, Bacteriophages/genetics, Base Sequence, Butyrates/metabolism, Butyric Acid, Cloning, Molecular, Clostridium/enzymology/genetics, Coenzyme A-Transferases/biosynthesis/genetics, DNA, Bacterial/analysis, DNA, Recombinant/analysis, Gene Expression, Genes, Bacterial, Molecular Sequence Data, Oligonucleotide Probes, Restriction Mapping, Sequence Homology, Nucleic Acid	Metabolism
Metabolism	2556163	Pyruvate fermentation by Clostridium acetobutylicum.	Janati-Idrissi R, Junelles AM, el Kanouni A, Petitdemange H, Gay R	Biochem Cell Biol	10.1139/o89-110	1989	Acetate Kinase/metabolism, Carboxy-Lyases/metabolism, Clostridium/metabolism, Fermentation, Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism, Phosphotransferases/metabolism, Phosphotransferases (Carboxyl Group Acceptor), Pyruvates/*metabolism	Enzymology
Enzymology	2661316	Cloning and expression of a Clostridium acetobutylicum alpha-amylase gene in Escherichia coli.	Verhasselt P, Poncelet F, Vits K, Van Gool A, Vanderleyden J	FEMS Microbiol Lett	10.1111/j.1574-6968.1989.tb03097.x	1989	Chromosome Mapping, Cloning, Molecular, Clostridium/enzymology/genetics, Escherichia coli/genetics, alpha-Amylases/analysis/genetics
Enzymology	2673038	Purification and characterization of the NADH-dependent butanol dehydrogenase from Clostridium acetobutylicum (ATCC 824).	Welch RW, Rudolph FB, Papoutsakis ET	Arch Biochem Biophys	10.1016/0003-9861(89)90489-x	1989	Alcohol Oxidoreductases/isolation & purification/metabolism, Clostridium/enzymology, Electrophoresis, Polyacrylamide Gel, Hydrogen-Ion Concentration, Kinetics, Molecular Weight, Substrate Specificity	Phylogeny
Enzymology	2719475	Phosphotransbutyrylase from Clostridium acetobutylicum ATCC 824 and its role in acidogenesis.	Wiesenborn DP, Rudolph FB, Papoutsakis ET	Appl Environ Microbiol	10.1128/aem.55.2.317-322.1989	1989	Acetyltransferases/isolation & purification, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Clostridium/enzymology, Hydrogen-Ion Concentration, Kinetics, Macromolecular Substances, Molecular Weight, Phosphate Acetyltransferase/*isolation & purification/metabolism, Substrate Specificity	Phylogeny
Enzymology	2719476	Coenzyme A transferase from Clostridium acetobutylicum ATCC 824 and its role in the uptake of acids.	Wiesenborn DP, Rudolph FB, Papoutsakis ET	Appl Environ Microbiol	10.1128/aem.55.2.323-329.1989	1989	Biological Transport, Carboxylic Acids/metabolism, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Clostridium/enzymology, Coenzyme A-Transferases/*isolation & purification/metabolism, Kinetics, Macromolecular Substances, Molecular Weight, Substrate Specificity	Metabolism
Metabolism	2742371	Isolation and characterization of xylose- and xylan-utilizing anaerobic bacteria.	Murty MV, Chandra TS	Antonie Van Leeuwenhoek	10.1007/BF00404755	1989	Animals, Bacteria, Anaerobic/isolation & purification/metabolism, Biodegradation, Environmental, Cellulose/metabolism, Fermentation, Polysaccharides/metabolism, Xylans/metabolism, Xylose/metabolism	Phylogeny
Enzymology	6409358	[Effect of growth phase and composition of the medium on the rate of biosynthesis of NADH: rubredoxin oxidoreductase in Clostridium acetobutylicum].	Marczak R, Petitdemange H, Alimi F, Ballongue J, Gay R	C R Seances Acad Sci III		1983	Clostridium/drug effects/metabolism, Culture Media/pharmacology, Enzyme Induction/drug effects, NADH, NADPH Oxidoreductases/*biosynthesis	Pathogenicity
Pathogenicity	6696415	Effect of butanol on lipid composition and fluidity of Clostridium acetobutylicum ATCC 824.	Vollherbst-Schneck K, Sands JA, Montenecourt BS	Appl Environ Microbiol	10.1128/aem.47.1.193-194.1984	1984	Butanols/pharmacology, Clostridium/analysis/drug effects, Membrane Fluidity/drug effects, Membrane Lipids/*analysis	Lipids
Enzymology	7539689	A Clostridium acetobutylicum regulator gene (regA) affecting amylase production in Bacillus subtilis.	Davison SP, Santangelo JD, Reid SJ, Woods DR	Microbiology (Reading)	10.1099/13500872-141-4-989	1995	Acetoin/metabolism, Amino Acid Sequence, Amylases/biosynthesis, Bacillus subtilis/enzymology/genetics, Bacterial Proteins/genetics, Base Sequence, Cloning, Molecular, Clostridium/drug effects/genetics, DNA, Bacterial/genetics, Drug Resistance, Microbial/genetics, Genes, Bacterial, Genes, Regulator, Genetic Complementation Test, Metronidazole/pharmacology, Molecular Sequence Data, Mutation, Plasmids/genetics, Sequence Homology, Amino Acid, Starch/metabolism	Metabolism
Phylogeny	7547288	Taxonomy and phylogeny of industrial solvent-producing clostridia.	Keis S, Bennett CF, Ward VK, Jones DT	Int J Syst Bacteriol	10.1099/00207713-45-4-693	1995	Bacterial Typing Techniques, Base Sequence, Clostridium/classification/genetics/metabolism, DNA Fingerprinting, DNA, Ribosomal/chemistry, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, 16S/genetics, Solvents/metabolism, Terminology as Topic	Metabolism
Enzymology	7576768	Alcohol dehydrogenase: multiplicity and relatedness in the solvent-producing clostridia.	Chen JS	FEMS Microbiol Rev	10.1111/j.1574-6976.1995.tb00210.x	1995	Alcohol Dehydrogenase/chemistry/genetics/metabolism, Amino Acid Sequence, Clostridium/enzymology, Molecular Sequence Data, Sequence Homology, Amino Acid, Solvents/*metabolism	Metabolism
Genetics	7576769	Molecular genetics and the initiation of solventogenesis in Clostridium beijerinckii (formerly Clostridium acetobutylicum) NCIMB 8052.	Wilkinson SR, Young DI, Morris JG, Young M	FEMS Microbiol Rev	10.1111/j.1574-6976.1995.tb00211.x	1995	Base Sequence, Chromosome Mapping, Clostridium/genetics/metabolism/physiology, Gene Transfer Techniques, Genes, Bacterial/physiology, Molecular Sequence Data, Solvents/*metabolism, Spores, Bacterial	Metabolism
Metabolism	7765050	Analysis of Tn916-induced mutants of Clostridium acetobutylicum altered in solventogenesis and sporulation.	Mattsson DM, Rogers P	J Ind Microbiol	10.1007/BF01569758	1994	Acetone/metabolism, Base Sequence, Butanols/metabolism, Clostridium/enzymology/genetics/metabolism/physiology, Ethanol/metabolism, Gene Transfer Techniques, Molecular Sequence Data, Mutagenesis, Insertional, Mutation/*genetics, Species Specificity, Spores, Bacterial	Genetics
	7814334	Physical map of the Clostridium beijerinckii (formerly Clostridium acetobutylicum) NCIMB 8052 chromosome.	Wilkinson SR, Young M	J Bacteriol	10.1128/jb.177.2.439-448.1995	1995	Chromosome Mapping/methods, Chromosomes, Bacterial, Clostridium/genetics, rRNA Operon/genetics
Metabolism	7851742	Cyclic AMP in ruminal and other anaerobic bacteria.	Cotta MA, Wheeler MB, Whitehead TR	FEMS Microbiol Lett	10.1111/j.1574-6968.1994.tb07308.x	1994	Animals, Bacteria, Anaerobic/growth & development/metabolism, Binding, Competitive, Cyclic AMP/analysis, Escherichia coli/metabolism, Radioimmunoassay, Rumen/microbiology
Enzymology	7867955	Characterization of an acetyl-CoA C-acetyltransferase (thiolase) gene from Clostridium acetobutylicum ATCC 824.	Stim-Herndon KP, Petersen DJ, Bennett GN	Gene	10.1016/0378-1119(94)00838-j	1995	Acetyl-CoA C-Acetyltransferase/genetics, Amino Acid Sequence, Bacteria/enzymology/genetics, Bacterial Proteins/genetics, Base Sequence, Clostridium/enzymology/genetics, Genes, Bacterial, Molecular Sequence Data, Open Reading Frames, Promoter Regions, Genetic, Sequence Alignment, Sequence Homology, Amino Acid, Species Specificity	Genetics
Genetics	7883192	Sequence and arrangement of genes encoding sigma factors in Clostridium acetobutylicum ATCC 824.	Wong J, Sass C, Bennett GN	Gene	10.1016/0378-1119(94)00818-d	1995	Amino Acid Sequence, Bacillus subtilis/genetics, Base Sequence, Clostridium/genetics, DNA, Bacterial/genetics, Genes, Bacterial, Molecular Sequence Data, Sigma Factor/*genetics
Enzymology	7903254	Role of the C-terminal domain of the lysozyme of Clostridium acetobutylicum ATCC 824 in a chimeric pneumococcal-clostridial cell wall lytic enzyme.	Croux C, Ronda C, Lopez R, Garcia JL	FEBS Lett	10.1016/0014-5793(93)81621-6	1993	Catalysis, Cell Wall/enzymology, Clostridium/enzymology, Hydrolysis, Muramidase/chemistry/metabolism, N-Acetylmuramoyl-L-alanine Amidase/metabolism, Recombinant Fusion Proteins/chemistry/metabolism, Streptococcus pneumoniae/*enzymology, Substrate Specificity	Metabolism
Enzymology	7934908	Interchange of functional domains switches enzyme specificity: construction of a chimeric pneumococcal-clostridial cell wall lytic enzyme.	Croux C, Ronda C, Lopez R, Garcia JL	Mol Microbiol	10.1111/j.1365-2958.1993.tb01231.x	1993	Amino Acid Sequence, Base Sequence, Carrier Proteins/biosynthesis/isolation & purification/metabolism, Cell Wall/metabolism, Chromatography, Affinity, Clostridium/enzymology, DNA, Bacterial/chemistry/metabolism, Genes, Bacterial, Molecular Sequence Data, Muramidase/biosynthesis/isolation & purification, N-Acetylmuramoyl-L-alanine Amidase/biosynthesis/isolation & purification/metabolism, Plasmids, Recombinant Fusion Proteins/biosynthesis/isolation & purification/metabolism, Restriction Mapping, Streptococcus pneumoniae/*enzymology	Metabolism
Enzymology	7961408	Sporulation and primary sigma factor homologous genes in Clostridium acetobutylicum.	Sauer U, Treuner A, Buchholz M, Santangelo JD, Durre P	J Bacteriol	10.1128/jb.176.21.6572-6582.1994	1994	Amino Acid Sequence, Bacterial Proteins/genetics, Base Sequence, Cloning, Molecular, Clostridium/genetics/growth & development, DNA Polymerase III/genetics, DNA-Directed RNA Polymerases/genetics, Gene Expression Regulation, Bacterial, Genes, Bacterial/genetics, Genomic Library, Molecular Sequence Data, Operon/genetics, Polymerase Chain Reaction, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sigma Factor/genetics, Spores, Bacterial/genetics/growth & development, Transcription Factors/genetics, Transcription, Genetic	Genetics
Metabolism	8083176	Expression of plasmid-encoded aad in Clostridium acetobutylicum M5 restores vigorous butanol production.	Nair RV, Papoutsakis ET	J Bacteriol	10.1128/jb.176.18.5843-5846.1994	1994	Alcohol Oxidoreductases/biosynthesis/chemistry/genetics/metabolism, Aldehyde Oxidoreductases/biosynthesis/chemistry/genetics/metabolism, Bacterial Proteins, Butanols/metabolism, Clostridium/enzymology/genetics/metabolism, Fermentation, Genes, Bacterial, Genetic Complementation Test, Molecular Weight, Multienzyme Complexes/biosynthesis/chemistry/genetics/metabolism, Mutation/physiology, Plasmids/genetics	Enzymology
Metabolism	8117087	Heterologous expression of endo-beta-1,4-D-glucanase from Clostridium cellulovorans in Clostridium acetobutylicum ATCC 824 following transformation of the engB gene.	Kim AY, Attwood GT, Holt SM, White BA, Blaschek HP	Appl Environ Microbiol	10.1128/aem.60.1.337-340.1994	1994	Biodegradation, Environmental, Carboxymethylcellulose Sodium/metabolism, Cellulase/genetics/immunology, Clostridium/enzymology/genetics/immunology, Escherichia coli/genetics, Fermentation, Gene Expression, Genes, Bacterial, Immunochemistry, Plasmids/genetics, Transformation, Genetic	Enzymology
Metabolism	8244020	Sequence and arrangement of two genes of the butyrate-synthesis pathway of Clostridium acetobutylicum ATCC 824.	Walter KA, Nair RV, Cary JW, Bennett GN, Papoutsakis ET	Gene	10.1016/0378-1119(93)90182-3	1993	Amino Acid Sequence, Base Sequence, Butyrates/metabolism, Clostridium/genetics/metabolism, DNA, Bacterial, Genes, Bacterial, Molecular Sequence Data, Open Reading Frames, Operon, Phosphate Acetyltransferase/genetics, Phosphotransferases (Carboxyl Group Acceptor)/*genetics, Protein Biosynthesis, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Transcription, Genetic	Genetics
Enzymology	8300540	Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824.	Nair RV, Bennett GN, Papoutsakis ET	J Bacteriol	10.1128/jb.176.3.871-885.1994	1994	Alcohol Dehydrogenase/genetics, Alcohol Oxidoreductases/genetics, Aldehyde Dehydrogenase/genetics, Aldehyde Oxidoreductases/genetics, Amino Acid Sequence, Bacterial Proteins, Base Sequence, Clostridium/enzymology/genetics, Fermentation, Gene Expression, Genes, Bacterial, Molecular Sequence Data, Molecular Weight, Multienzyme Complexes/genetics, Promoter Regions, Genetic, RNA, Messenger/genetics, Restriction Mapping, Sequence Alignment, Sequence Homology, Amino Acid, Transcription, Genetic	Genetics
Enzymology	8386500	In vivo methylation in Escherichia coli by the Bacillus subtilis phage phi 3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824.	Mermelstein LD, Papoutsakis ET	Appl Environ Microbiol	10.1128/aem.59.4.1077-1081.1993	1993	Amino Acid Sequence, Bacillus subtilis, Bacteriophages/enzymology, Clostridium/enzymology/genetics, DNA Restriction Enzymes/genetics/metabolism, DNA, Bacterial/metabolism, Escherichia coli/enzymology/genetics, Gene Expression Regulation, Enzymologic, Genetic Vectors, Methylation, Methyltransferases/genetics/metabolism, Molecular Sequence Data, Plasmids/genetics/metabolism, Transfection, Transformation, Bacterial/genetics	Metabolism
Enzymology	8396545	Cloning and sequence analysis of the genes encoding phosphotransbutyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052.	Oultram JD, Burr ID, Elmore MJ, Minton NP	Gene	10.1016/0378-1119(93)90677-u	1993	Amino Acid Sequence, Bacillus subtilis/genetics, Base Sequence, Cloning, Molecular, Clostridium/enzymology/genetics, DNA Mutational Analysis, DNA, Bacterial/analysis, Dihydropteroate Synthase/genetics, Escherichia coli, Genes, Bacterial, Molecular Sequence Data, Open Reading Frames, Phosphate Acetyltransferase/genetics, Phosphotransferases/genetics, Phosphotransferases (Carboxyl Group Acceptor), Recombinant Fusion Proteins, Restriction Mapping, Sequence Homology, Amino Acid, Species Specificity	Genetics
Metabolism	8423010	Sequence and arrangement of genes encoding enzymes of the acetone-production pathway of Clostridium acetobutylicum ATCC824.	Petersen DJ, Cary JW, Vanderleyden J, Bennett GN	Gene	10.1016/0378-1119(93)90545-e	1993	Acetone/metabolism, Acyl Coenzyme A/genetics/metabolism, Amino Acid Sequence, Base Sequence, Carboxy-Lyases/genetics/metabolism, Clostridium/enzymology/genetics, DNA, Bacterial, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Nucleic Acid Conformation, Protein Biosynthesis, Restriction Mapping, Transcription, Genetic	Enzymology
Genetics	8509336	Construction and characterization of a phage-plasmid hybrid (phagemid), pCAK1, containing the replicative form of viruslike particle CAK1 isolated from Clostridium acetobutylicum NCIB 6444.	Kim AY, Blaschek HP	J Bacteriol	10.1128/jb.175.12.3838-3843.1993	1993	Bacteriophages/genetics, Clostridium/genetics, DNA Replication, DNA, Bacterial/genetics, DNA, Recombinant, DNA, Viral/genetics, Defective Viruses/genetics, Escherichia coli/genetics, Genetic Vectors, *Plasmids, Transformation, Genetic
	8514119	Determination of plasmid copy number and stability in Clostridium acetobutylicum ATCC 824.	Lee SY, Mermelstein LD, Papoutsakis ET	FEMS Microbiol Lett	10.1111/j.1574-6968.1993.tb06122.x	1993	Clostridium/genetics/growth & development, Plasmids
Enzymology	8626337	Molecular characterization and transcriptional analysis of the putative hydrogenase gene of Clostridium acetobutylicum ATCC 824.	Gorwa MF, Croux C, Soucaille P	J Bacteriol	10.1128/jb.178.9.2668-2675.1996	1996	Amino Acid Sequence, Base Sequence, Cloning, Molecular, Clostridium/enzymology/genetics, Gene Expression Regulation, Bacterial, Genes, Bacterial/genetics, Hydrogenase/chemistry/*genetics, Molecular Sequence Data, Open Reading Frames/genetics, RNA, Bacterial/biosynthesis, RNA, Messenger/biosynthesis, Sequence Alignment, Sequence Analysis, DNA, Transcription, Genetic/genetics	Genetics
Metabolism	8640107	Recombination-induced variants of Clostridium acetobutylicum ATCC 824 with increased solvent production.	Wong J, Bennett GN	Curr Microbiol	10.1007/s002849900062	1996	Clostridium/genetics/metabolism/physiology, Escherichia coli/genetics, Gene Expression Regulation, Bacterial, Genes, Bacterial/genetics, Plasmids, Solvents/metabolism, Spores, Bacterial, *Transformation, Bacterial	Biotechnology
Enzymology	8655474	Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824.	Boynton ZL, Bennet GN, Rudolph FB	J Bacteriol	10.1128/jb.178.11.3015-3024.1996	1996	3-Hydroxyacyl CoA Dehydrogenases/chemistry/genetics, Amino Acid Sequence, Base Sequence, Butyryl-CoA Dehydrogenase, Cloning, Molecular, Clostridium/enzymology/genetics, Enoyl-CoA Hydratase/chemistry/genetics, Fatty Acid Desaturases/chemistry/genetics, Genes, Bacterial, Molecular Sequence Data, Multigene Family	Genetics
Enzymology	8669898	Inactivation of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824.	Green EM, Bennett GN	Appl Biochem Biotechnol	10.1007/BF02941702	1996	Alcohol Dehydrogenase/genetics, Aldehyde Dehydrogenase/genetics, Blotting, Southern, Clostridium/enzymology/genetics, Electroporation, Gene Expression Regulation, Bacterial/physiology, Transformation, Genetic
Enzymology	8702268	Cloning, sequencing, and expression of genes encoding phosphotransacetylase and acetate kinase from Clostridium acetobutylicum ATCC 824.	Boynton ZL, Bennett GN, Rudolph FB	Appl Environ Microbiol	10.1128/aem.62.8.2758-2766.1996	1996	Acetate Kinase/chemistry/genetics, Amino Acid Sequence, Base Sequence, Cloning, Molecular, Clostridium/enzymology/genetics, Gene Library, Genes, Bacterial, Molecular Sequence Data, Phosphate Acetyltransferase/chemistry/genetics, Sequence Alignment	Genetics
Metabolism	8760920	Genetic manipulation of acid formation pathways by gene inactivation in Clostridium acetobutylicum ATCC 824.	Green EM, Boynton ZL, Harris LM, Rudolph FB, Papoutsakis ET, Bennett GN	Microbiology (Reading)	10.1099/13500872-142-8-2079	1996	Acetates/metabolism, Butyrates/metabolism, Chromosomes, Bacterial, Clostridium/genetics/growth & development/metabolism, Escherichia coli, Fermentation, Genes, Bacterial, Kinetics, Phosphate Acetyltransferase/biosynthesis/genetics, Phosphotransferases (Carboxyl Group Acceptor)/biosynthesis/genetics, Plasmids, *Recombination, Genetic, Species Specificity	Enzymology
Enzymology	8967771	Purification and characterization of the extracellular alpha-amylase from Clostridium acetobutylicum ATCC 824.	Paquet V, Croux C, Goma G, Soucaille P	Appl Environ Microbiol	10.1128/aem.57.1.212-218.1991	1991	Amino Acid Sequence, Clostridium/enzymology, Hydrogen-Ion Concentration, Molecular Sequence Data, Substrate Specificity, alpha-Amylases/chemistry/isolation & purification/metabolism	Genetics
Phylogeny	9103631	Cultures of "Clostridium acetobutylicum" from various collections comprise Clostridium acetobutylicum, Clostridium beijerinckii, and two other distinct types based on DNA-DNA reassociation.	Johnson JL, Toth J, Santiwatanakul S, Chen JS	Int J Syst Bacteriol	10.1099/00207713-47-2-420	1997	1-Butanol, Acetone/metabolism, Butanols/metabolism, Clostridium/classification/genetics/metabolism, DNA, Bacterial/*genetics, Molecular Sequence Data, Nucleic Acid Hybridization, Phenotype, Riboflavin/biosynthesis, Species Specificity	Metabolism
Metabolism	9286999	The genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 reside on a large plasmid whose loss leads to degeneration of the strain.	Cornillot E, Nair RV, Papoutsakis ET, Soucaille P	J Bacteriol	10.1128/jb.179.17.5442-5447.1997	1997	Acetone/metabolism, Alcohol Oxidoreductases/genetics, Aldehyde Oxidoreductases/genetics, Bacterial Proteins/genetics, Butanols/metabolism, Carboxy-Lyases/genetics, Clostridium/enzymology/genetics/metabolism, Coenzyme A-Transferases/genetics, Conjugation, Genetic, Genes, Bacterial/genetics, Multienzyme Complexes/genetics, Operon/genetics, Plasmids/*genetics/metabolism, Restriction Mapping	Enzymology
Enzymology	9353928	Acetate kinase from Clostridium acetobutylicum: a highly specific enzyme that is actively transcribed during acidogenesis and solventogenesis.	Winzer K, Lorenz K, DUrre P	Microbiology (Reading)	10.1099/00221287-143-10-3279	1997	Acetate Kinase/chemistry/genetics/metabolism, Acids/metabolism, Base Sequence, Cloning, Molecular, Clostridium/enzymology/genetics/metabolism, Dimerization, Kinetics, Molecular Weight, Oligodeoxyribonucleotides/genetics, Solvents/metabolism, Substrate Specificity, Transcription, Genetic	Metabolism
Genetics	9393708	Physical and genetic map of the Clostridium acetobutylicum ATCC 824 chromosome.	Cornillot E, Croux C, Soucaille P	J Bacteriol	10.1128/jb.179.23.7426-7434.1997	1997	Chromosomes, Bacterial, Clostridium/genetics, DNA, Bacterial/genetics, DNA, Ribosomal/genetics, Endodeoxyribonucleases, Gene Dosage, Gene Expression, Genes, Bacterial, *Genome, Bacterial, Nucleic Acid Hybridization, Oligonucleotide Probes, Operon, Restriction Mapping	Phylogeny
Metabolism	9501448	Expression of Clostridium acetobutylicum ATCC 824 genes in Escherichia coli for acetone production and acetate detoxification.	Bermejo LL, Welker NE, Papoutsakis ET	Appl Environ Microbiol	10.1128/AEM.64.3.1079-1085.1998	1998	Acetates/metabolism, Acetone/metabolism, Bioreactors, Cloning, Molecular, Clostridium/genetics, Escherichia coli/genetics/metabolism, Genes, Bacterial, Glucose/metabolism, Hydrogen-Ion Concentration	Enzymology
Enzymology	9504995	Complementation of an Escherichia coli polypeptide deformylase mutant with a gene from Clostridium acetobutylicum ATCC 824.	Belouski E, Gui L, Rudolph FB, Bennett GN	Curr Microbiol	10.1007/s002849900304	1998	Amidohydrolases, Aminopeptidases/genetics, Clostridium/enzymology/genetics, Escherichia coli/enzymology/genetics, Genes, Bacterial/genetics, Hydroxymethyl and Formyl Transferases/genetics, Mutation, Operon/genetics, Peptides
Enzymology	9625784	Cloning, sequence, and expression of the phosphofructokinase gene of Clostridium acetobutylicum ATCC 824 in Escherichia coli.	Belouski E, Watson DE, Bennett GN	Curr Microbiol	10.1007/s002849900330	1998	Amino Acid Sequence, Animals, Bacterial Proteins/genetics, Base Sequence, Clostridium/enzymology/genetics, Escherichia coli/genetics, Genes, Bacterial/genetics, Molecular Sequence Data, Operon/genetics, Phosphofructokinase-1/*genetics, Polymerase Chain Reaction, Pyruvate Kinase/genetics	Genetics
Metabolism	9864345	Regulation of the sol locus genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 by a putative transcriptional repressor.	Nair RV, Green EM, Watson DE, Bennett GN, Papoutsakis ET	J Bacteriol	10.1128/JB.181.1.319-330.1999	1999	1-Butanol/metabolism, Acetone/metabolism, Amino Acid Sequence, Bacterial Proteins/chemistry/genetics/metabolism, Base Sequence, Clostridium/genetics/metabolism, DNA Primers/genetics, Fermentation, Gene Expression, Genes, Bacterial, Molecular Sequence Data, Mutation, Open Reading Frames, Plasmids/genetics, Protein Structure, Secondary, Repressor Proteins/chemistry/genetics/*metabolism, Sequence Homology, Amino Acid, Transcription, Genetic	Genetics
Enzymology	9866174	Electroporation of, plasmid isolation from and plasmid conservation in Clostridium acetobutylicum DSM 792.	Nakotte S, Schaffer S, Bohringer M, Durre P	Appl Microbiol Biotechnol	10.1007/s002530051335	1998	Anaerobiosis, Clostridium/genetics/growth & development/metabolism, Electrophoresis, Agar Gel, Electroporation/methods, Genetic Engineering, Plasmids/genetics/isolation & purification, Spores, Bacterial, Transformation, Bacterial	Phylogeny
Metabolism	10049845	Antisense RNA strategies for metabolic engineering of Clostridium acetobutylicum.	Desai RP, Papoutsakis ET	Appl Environ Microbiol	10.1128/AEM.65.3.936-945.1999	1999	Acetone/metabolism, Base Sequence, Bioreactors, Butanols/metabolism, Butyrates/metabolism, Clostridium/enzymology/genetics/growth & development, Ethanol/metabolism, Fermentation, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Enzymologic, Genetic Engineering, Molecular Sequence Data, Phosphate Acetyltransferase/genetics/metabolism, Phosphotransferases (Carboxyl Group Acceptor)/genetics/metabolism, Plasmids/genetics, RNA, Antisense/genetics, RNA, Bacterial/genetics	Genetics
	10191392	Genetic manipulation of acid and solvent formation in clostridium acetobutylicum ATCC 824	Green EM, Bennett GN	Biotechnol Bioeng	10.1002/(sici)1097-0290(19980420)58:2/3<215::aid-bit14>3.0.co;2-b	1998
Enzymology	10388730	Characterization of methylglyoxal synthase from Clostridium acetobutylicum ATCC 824 and its use in the formation of 1, 2-propanediol.	Huang K, Rudolph FB, Bennett GN	Appl Environ Microbiol	10.1128/AEM.65.7.3244-3247.1999	1999	Amino Acid Sequence, Carbon-Oxygen Lyases/chemistry/genetics/isolation & purification/metabolism, Cloning, Molecular, Clostridium/enzymology/genetics, DNA, Bacterial, Escherichia coli/enzymology/genetics, Genetic Engineering, Molecular Sequence Data, Propylene Glycol/metabolism, Recombinant Proteins/chemistry/metabolism, Sequence Alignment, Substrate Specificity	Metabolism
Enzymology	10463150	The glyceraldehyde-3-phosphate dehydrogenase of Clostridium acetobutylicum: isolation and purification of the enzyme, and sequencing and localization of the gap gene within a cluster of other glycolytic genes.	Schreiber W, Durre P	Microbiology (Reading)	10.1099/13500872-145-8-1839	1999	Cloning, Molecular, Clostridium/enzymology/genetics, Electrophoresis, Polyacrylamide Gel, Escherichia coli/enzymology/genetics, Genes, Bacterial/genetics, Genetic Complementation Test, Glyceraldehyde-3-Phosphate Dehydrogenases/genetics/isolation & purification/metabolism, Glycolysis, Molecular Sequence Data, Multigene Family/genetics, Nucleic Acid Hybridization, Polymerase Chain Reaction/methods, Sequence Analysis, DNA	Phylogeny
Enzymology	10473377	Development and characterization of a gene expression reporter system for Clostridium acetobutylicum ATCC 824.	Tummala SB, Welker NE, Papoutsakis ET	Appl Environ Microbiol	10.1128/AEM.65.9.3793-3799.1999	1999	Acetyl-CoA C-Acetyltransferase/genetics, Carboxy-Lyases/genetics, Clostridium/enzymology/genetics, Enzyme Stability, Fermentation, Gene Expression, Genes, Reporter, Hydrogen-Ion Concentration, Lac Operon, Phosphate Acetyltransferase/genetics, Promoter Regions, Genetic, Transformation, Bacterial, beta-Galactosidase/genetics/metabolism	Metabolism
	10508051	Stable Escherichia coli-Clostridium acetobutylicum shuttle vector for secretion of murine tumor necrosis factor alpha.	Theys J, Nuyts S, Landuyt W, Van Mellaert L, Dillen C, Bohringer M, Durre P, Lambin P, Anne J	Appl Environ Microbiol	10.1128/AEM.65.10.4295-4300.1999	1999	Animals, Clostridium/genetics, Escherichia coli/genetics, Genetic Vectors, Mice, Recombinant Proteins/biosynthesis, Tumor Necrosis Factor-alpha/*biosynthesis/genetics/pharmacology
Enzymology	10543811	The ald gene, encoding a coenzyme A-acylating aldehyde dehydrogenase, distinguishes Clostridium beijerinckii and two other solvent-producing clostridia from Clostridium acetobutylicum.	Toth J, Ismaiel AA, Chen JS	Appl Environ Microbiol	10.1128/AEM.65.11.4973-4980.1999	1999	Aldehyde Oxidoreductases/chemistry/genetics/metabolism, Amino Acid Sequence, Animals, Clostridium/classification/genetics, Genes, Bacterial, Macromolecular Substances, Molecular Sequence Data, Open Reading Frames, Peptide Fragments/chemistry, Rats, Restriction Mapping, Sequence Alignment, Sequence Homology, Amino Acid, Species Specificity	Phylogeny
Cultivation	10735989	Electrotransformation of Clostridium acetobutylicum ATCC 824 using high-voltage radio frequency modulated square pulses.	Tyurin M, Padda R, Huang KX, Wardwell S, Caprette D, Bennett GN	J Appl Microbiol	10.1046/j.1365-2672.2000.00032.x	2000	Clostridium/genetics/growth & development/ultrastructure, Culture Media, Electric Stimulation/instrumentation/methods, Electroporation/methods, Microscopy, Electron, Plasmids/genetics, *Transformation, Bacterial
Metabolism	10812180	Isolation of mesophilic solvent-producing clostridia from Colombian sources: physiological characterization, solvent production and polysaccharide hydrolysis.	Montoya D, Spitia S, Silva E, Schwarz WH	J Biotechnol	10.1016/s0168-1656(00)00218-2	2000	Clostridium/drug effects/metabolism, Hydrolysis, Microbial Sensitivity Tests, Polysaccharides/metabolism, Solvents	Phylogeny
Transcriptome	10902917	Sequence analysis of the atp operon of Clostridium acetobutylicum DSM 792 encoding the F0F1 ATP synthase.	Externbrink T, Hujer S, Winzer K, Durre P	DNA Seq	10.3109/10425170009033977	2000	Amino Acid Sequence, Base Sequence, Clostridium/enzymology/genetics, DNA, Bacterial, Genes, Bacterial, Molecular Sequence Data, Operon, Protein Biosynthesis, Proton-Translocating ATPases/genetics, Sequence Analysis, DNA, Transcription, Genetic	Genetics
Enzymology	10937434	Identification of two genes encoding putative new members of the ECF subfamily of eubacterial RNA polymerase sigma factors in Clostridium acetobutylicum.	Behrens S, Meyer U, Schankin H, Lonetto MA, Fischer RJ, Bahl H	J Mol Microbiol Biotechnol		2000	Amino Acid Sequence, Bacillus subtilis/genetics, Bacterial Proteins, Cloning, Molecular, Clostridium/genetics, Epidermal Growth Factor/genetics, Escherichia coli Proteins, Molecular Sequence Data, Open Reading Frames, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sigma Factor/genetics/metabolism	Genetics
Enzymology	10937485	Identification and characterization of a second butyrate kinase from Clostridium acetobutylicum ATCC 824.	Huang KX, Huang S, Rudolph FB, Bennett GN	J Mol Microbiol Biotechnol		2000	Amino Acid Sequence, Blotting, Western, Cloning, Molecular, Clostridium/enzymology/genetics, Escherichia coli/genetics, Molecular Sequence Data, Mutation, Phosphotransferases (Carboxyl Group Acceptor)/genetics/isolation & purification/*metabolism, Polymerase Chain Reaction, RNA, Messenger, Sequence Analysis, Sequence Homology, Amino Acid	Genetics
Metabolism	10937490	Analysis of a catabolic operon for sucrose transport and metabolism in Clostridium acetobutylicum ATCC 824.	Tangney M, Mitchell WJ	J Mol Microbiol Biotechnol		2000	Amino Acid Sequence, Bacterial Proteins/genetics/metabolism, Base Sequence, Biological Transport, Clostridium/genetics/metabolism, Fructokinases/genetics/metabolism, Genes, Bacterial, Glycoside Hydrolases/genetics/metabolism, Molecular Sequence Data, Operon, Regulatory Sequences, Nucleic Acid, Sequence Homology, Amino Acid, Species Specificity, Sucrose/metabolism, beta-Fructofuranosidase	Genetics
Metabolism	10968627	Utilisation of saccharides in extruded domestic organic waste by Clostridium acetobutylicum ATCC 824 for production of acetone, butanol and ethanol.	Lopez-Contreras AM, Claassen PA, Mooibroek H, De Vos WM	Appl Microbiol Biotechnol	10.1007/s002530000374	2000	Acetone/metabolism, Butanols/metabolism, Carbohydrate Metabolism, Cellulase/metabolism, Clostridium/metabolism, Disaccharides/metabolism, Ethanol/metabolism, Fermentation, Hydrolysis, Oligosaccharides/metabolism, Solubility, Waste Products, beta-Glucosidase/metabolism	Biotechnology
Metabolism	10972834	Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia.	Ravagnani A, Jennert KC, Steiner E, Grunberg R, Jefferies JR, Wilkinson SR, Young DI, Tidswell EC, Brown DP, Youngman P, Morris JG, Young M	Mol Microbiol	10.1046/j.1365-2958.2000.02071.x	2000	Acids, Bacterial Proteins/genetics/metabolism, Base Sequence, Carboxy-Lyases/genetics, Clostridium/enzymology/genetics/metabolism, DNA, Bacterial, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Enzymologic, Genes, Bacterial, Molecular Sequence Data, Phenotype, Phosphate Acetyltransferase/genetics, Promoter Regions, Genetic, Solvents, Spores, Bacterial, Transcription Factors/genetics/*metabolism	Genetics
Enzymology	11075929	Differential regulation of two thiolase genes from Clostridium acetobutylicum DSM 792.	Winzer K, Lorenz K, Zickner B, Durre P	J Mol Microbiol Biotechnol		2000	Acetyl-CoA C-Acetyltransferase/chemistry/genetics/metabolism, Amino Acid Sequence, Bacterial Proteins/genetics, Base Sequence, Cloning, Molecular, Clostridium/enzymology/genetics, Consensus Sequence, DNA-Directed RNA Polymerases/genetics, Escherichia coli, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Enzymologic, Isoenzymes/chemistry/genetics/metabolism, Kinetics, Molecular Sequence Data, Polymerase Chain Reaction, Promoter Regions, Genetic, Recombinant Proteins/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Sigma Factor/genetics, Transcription, Genetic	Metabolism
Metabolism	11160802	Molecular analysis of the mannitol operon of Clostridium acetobutylicum encoding a phosphotransferase system and a putative PTS-modulated regulator.	Behrens S, Mitchell W, Bahl H	Microbiology (Reading)	10.1099/00221287-147-1-75	2001	Amino Acid Sequence, Clostridium/genetics/metabolism, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Mannitol/metabolism, Molecular Sequence Data, Operon, Phosphoenolpyruvate Sugar Phosphotransferase System/genetics/metabolism, Phosphorylation, RNA, Messenger/metabolism, Repressor Proteins/*genetics/metabolism, Sequence Analysis, DNA	Genetics
Genetics	11466286	Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum.	Nolling J, Breton G, Omelchenko MV, Makarova KS, Zeng Q, Gibson R, Lee HM, Dubois J, Qiu D, Hitti J, Wolf YI, Tatusov RL, Sabathe F, Doucette-Stamm L, Soucaille P, Daly MJ, Bennett GN, Koonin EV, Smith DR	J Bacteriol	10.1128/JB.183.16.4823-4838.2001	2001	Amino Acid Sequence, Bacterial Proteins/genetics, Base Sequence, Chromosomes, Bacterial/genetics, Clostridium/genetics/metabolism, Conserved Sequence, Enzymes/genetics, Genes, Bacterial, Genome, Bacterial, Models, Biological, Molecular Sequence Data, Operon, Phylogeny, Plasmids, Sequence Alignment, Sequence Homology, Amino Acid, Solvents/metabolism	Metabolism
Enzymology	11687934	Expression of the Klebsiella pneumoniae CG21 acetoin reductase gene in Clostridium acetobutylicum ATCC 824.	Wardwell SA, Yang YT, Chang HY, San KY, Rudolph FB, Bennett GN	J Ind Microbiol Biotechnol	10.1038/sj.jim.7000179	2001	Acetoin/metabolism, Alcohol Oxidoreductases/genetics/metabolism, Amino Acid Sequence, Base Sequence, Butylene Glycols/metabolism, Cloning, Molecular, Clostridium/enzymology/genetics/growth & development, Culture Media, Escherichia coli/enzymology/genetics/growth & development, Klebsiella pneumoniae/enzymology/genetics, Molecular Sequence Data, Plasmids, Sequence Analysis, DNA	Metabolism
Metabolism	11781805	Characterization of a maltose transport system in Clostridium acetobutylicum ATCC 824.	Tangney M, Winters GT, Mitchell WJ	J Ind Microbiol Biotechnol	10.1038/sj.jim.7000125	2001	Amino Acid Sequence, Bacterial Proteins, Base Sequence, Biological Transport, Cell Fractionation, Cell-Free System, Clostridium/genetics/metabolism, Genes, Bacterial, Glucose/metabolism, Maltose/metabolism, Molecular Sequence Data, Phosphoenolpyruvate Sugar Phosphotransferase System/genetics/metabolism, Phosphorylation, Sequence Homology, Amino Acid, Sucrose/metabolism, alpha-Glucosidases/genetics/metabolism	Genetics
Metabolism	11781806	Orf5/SolR: a transcriptional repressor of the sol operon of Clostridium acetobutylicum?	Thormann K, Durre P	J Ind Microbiol Biotechnol	10.1038/sj.jim.7000144	2001	Acetone/metabolism, Alcohol Dehydrogenase/genetics, Aldehyde Oxidoreductases/genetics, Bacterial Proteins/genetics/metabolism, Butanols/metabolism, Cloning, Molecular, Clostridium/genetics, Coenzyme A-Transferases, DNA-Binding Proteins/genetics/metabolism, Escherichia coli/genetics, Escherichia coli Proteins, Gene Expression Regulation, Bacterial, Genes, Bacterial, Multienzyme Complexes/genetics, Operon/genetics, Repressor Proteins/genetics/metabolism, Solvents/metabolism	Enzymology
Metabolism	11781807	Degeneration of solventogenic Clostridium strains monitored by Fourier transform infrared spectroscopy of bacterial cells.	Schuster KC, Goodacre R, Gapes JR, Young M	J Ind Microbiol Biotechnol	10.1038/sj.jim.7000146	2001	Acetone/metabolism, Bacterial Typing Techniques/methods, Biomass, Butanols/metabolism, Clostridium/classification/physiology, Fermentation, Industrial Microbiology/methods, Solvents/metabolism, Spectroscopy, Fourier Transform Infrared	Phylogeny
Metabolism	11790753	Molecular characterization and transcriptional analysis of adhE2, the gene encoding the NADH-dependent aldehyde/alcohol dehydrogenase responsible for butanol production in alcohologenic cultures of Clostridium acetobutylicum ATCC 824.	Fontaine L, Meynial-Salles I, Girbal L, Yang X, Croux C, Soucaille P	J Bacteriol	10.1128/JB.184.3.821-830.2002	2002	Alcohol Dehydrogenase/genetics/metabolism, Alcohol Oxidoreductases/genetics/metabolism, Aldehyde Oxidoreductases/genetics/metabolism, Amino Acid Sequence, Bacterial Proteins, Base Sequence, Butanols/metabolism, Clostridium/genetics/metabolism, Escherichia coli Proteins, Ethanol/metabolism, Fermentation/genetics, Gene Expression Regulation, Bacterial, Genes, Bacterial/genetics, Molecular Sequence Data, Multienzyme Complexes/genetics/metabolism, NAD/metabolism, Oxidoreductases/genetics/metabolism, Promoter Regions, Genetic, Sequence Analysis, DNA, Sequence Homology, Amino Acid	Enzymology
Phylogeny	12023083	amyP, a reporter gene to study strain degeneration in Clostridium acetobutylicum ATCC 824.	Sabathe F, Croux C, Cornillot E, Soucaille P	FEMS Microbiol Lett	10.1111/j.1574-6968.2002.tb11165.x	2002	Amino Acid Sequence, Bacterial Proteins/chemistry/genetics, Cloning, Molecular, Clostridium/classification/genetics, Genes, Reporter, Glycoside Hydrolases/chemistry/genetics, Molecular Sequence Data, Oligodeoxyribonucleotides/chemical synthesis/chemistry, Open Reading Frames, Sequence Alignment, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Species Specificity	Enzymology
Metabolism	12057953	Northern, morphological, and fermentation analysis of spo0A inactivation and overexpression in Clostridium acetobutylicum ATCC 824.	Harris LM, Welker NE, Papoutsakis ET	J Bacteriol	10.1128/JB.184.13.3586-3597.2002	2002	Bacterial Proteins/genetics/metabolism, Blotting, Northern, Clostridium/physiology, Fermentation, Gene Expression Regulation, Bacterial, Gene Silencing, Membrane Proteins/genetics, Microscopy, Phase-Contrast, Peptide Hydrolases, Sequence Analysis, DNA, Sigma Factor/genetics, Solvents, Spores, Bacterial/physiology, Transcription Factors/genetics/metabolism	Transcriptome
Genetics	12074052	Molecular characterization and utilization of the CAK1 filamentous viruslike particle derived from Clostridium beijerinckii.	Li Y, Blaschek HP, Tan D	J Ind Microbiol Biotechnol	10.1038/sj/jim/7000225	2002	Amino Acid Sequence, Clostridium/genetics/virology, DNA Replication, DNA, Viral/chemistry, Escherichia coli/genetics, Genetic Vectors, Molecular Sequence Data, Virion/*genetics
Phylogeny	12445640	Characterization of the cellulolytic complex (cellulosome) of Clostridium acetobutylicum.	Sabathe F, Belaich A, Soucaille P	FEMS Microbiol Lett	10.1111/j.1574-6968.2002.tb11450.x	2002	Amino Acid Sequence, Bacterial Proteins/classification/genetics/metabolism, Blotting, Western, Carrier Proteins/classification/genetics/metabolism, Cellulase/analysis/genetics/metabolism, Cellulose/metabolism, Clostridium/cytology/*enzymology/genetics, Gene Expression Regulation, Bacterial, Membrane Proteins/classification/genetics/metabolism, Molecular Sequence Data, Multigene Family/physiology, Phylogeny, Sequence Analysis, Protein/methods, Sequence Homology, Amino Acid, Substrate Specificity	Metabolism
Metabolism	12571006	Production by Clostridium acetobutylicum ATCC 824 of CelG, a cellulosomal glycoside hydrolase belonging to family 9.	Lopez-Contreras AM, Martens AA, Szijarto N, Mooibroek H, Claassen PA, van der Oost J, de Vos WM	Appl Environ Microbiol	10.1128/AEM.69.2.869-877.2003	2003	Amino Acid Sequence, Bacterial Proteins, Cellulase/biosynthesis/genetics, Cellulose/metabolism, Clostridium/enzymology/genetics, Culture Media, Glucans/metabolism, Glycoside Hydrolases/biosynthesis/genetics, Molecular Sequence Data, Multigene Family, Open Reading Frames, Recombinant Proteins/genetics/metabolism, Xylose/metabolism	Cultivation
Metabolism	12618456	Design of antisense RNA constructs for downregulation of the acetone formation pathway of Clostridium acetobutylicum.	Tummala SB, Welker NE, Papoutsakis ET	J Bacteriol	10.1128/JB.185.6.1923-1934.2003	2003	Acetone/metabolism, Bioreactors, Carboxy-Lyases/genetics/metabolism, Clostridium/genetics/growth & development/metabolism, Coenzyme A-Transferases/genetics/metabolism, Culture Media, Down-Regulation, Nucleic Acid Conformation, RNA, Antisense/chemistry/genetics	Cultivation
Enzymology	12685743	Biodegradation pathways of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by Clostridium acetobutylicum cell-free extract.	Zhang C, Hughes JB	Chemosphere	10.1016/s0045-6535(02)00639-2	2003	Anaerobiosis, Biodegradation, Environmental, Chromatography, High Pressure Liquid, Clostridium/chemistry, Environmental Pollutants/analysis, Kinetics, Mass Spectrometry, Oxidation-Reduction, Triazines/*analysis	Metabolism
Metabolism	12732555	Expression of a cloned cyclopropane fatty acid synthase gene reduces solvent formation in Clostridium acetobutylicum ATCC 824.	Zhao Y, Hindorff LA, Chuang A, Monroe-Augustus M, Lyristis M, Harrison ML, Rudolph FB, Bennett GN	Appl Environ Microbiol	10.1128/AEM.69.5.2831-2841.2003	2003	1-Propanol/metabolism, Bacterial Proteins/metabolism, Butanols/metabolism, Butyric Acid/metabolism, Cloning, Molecular, Clostridium/enzymology/genetics, Cyclopropanes/chemistry, Escherichia coli/genetics/growth & development/metabolism, Escherichia coli Proteins/genetics, Ethanol/metabolism, Fatty Acids/biosynthesis/chemistry, Gene Expression, Genes, Bacterial, Genetic Complementation Test, Kinetics, Methyltransferases/genetics/*metabolism, Phosphorylation, Phosphotransferases (Carboxyl Group Acceptor)/genetics/metabolism, Plasmids/genetics, Repressor Proteins/genetics, Solvents/metabolism, Transcription Factors/metabolism	Enzymology
Enzymology	12775702	Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations.	Tummala SB, Junne SG, Papoutsakis ET	J Bacteriol	10.1128/JB.185.12.3644-3653.2003	2003	Alcohol Dehydrogenase/biosynthesis/genetics, Alcohols/metabolism, Aldehyde Dehydrogenase/biosynthesis/genetics, Bioreactors, Clostridium/enzymology/genetics, Coenzyme A-Transferases/biosynthesis, Down-Regulation, Fermentation, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Enzymologic, Protein Engineering, RNA, Antisense/metabolism, RNA, Bacterial/metabolism	Metabolism
Metabolism	12902291	Overexpression of groESL in Clostridium acetobutylicum results in increased solvent production and tolerance, prolonged metabolism, and changes in the cell's transcriptional program.	Tomas CA, Welker NE, Papoutsakis ET	Appl Environ Microbiol	10.1128/AEM.69.8.4951-4965.2003	2003	1-Butanol/pharmacology, Bacterial Proteins/physiology, Blotting, Western, Carboxy-Lyases/biosynthesis, Chaperonins/physiology, Clostridium/genetics/growth & development/metabolism, Coenzyme A-Transferases/biosynthesis, Escherichia coli Proteins, Fermentation, Gene Expression Profiling, HSP70 Heat-Shock Proteins/analysis, Oligonucleotide Array Sequence Analysis, Solvents/metabolism, Transcription, Genetic	Biotechnology
Genetics	12902297	Development of a sensitive gene expression reporter system and an inducible promoter-repressor system for Clostridium acetobutylicum.	Girbal L, Mortier-Barriere I, Raynaud F, Rouanet C, Croux C, Soucaille P	Appl Environ Microbiol	10.1128/AEM.69.8.4985-4988.2003	2003	Base Sequence, Clostridium/genetics, Gene Expression Regulation, Bacterial, Genes, Reporter, Glucuronidase/genetics/metabolism, Hydrogenase/genetics, Iron-Sulfur Proteins/genetics, Molecular Sequence Data, Promoter Regions, Genetic, Repressor Proteins/*physiology, Transcription, Genetic	Metabolism
Enzymology	14570887	Genes malh and pagl of Clostridium acetobutylicum ATCC 824 encode NAD+- and Mn2+-dependent phospho-alpha-glucosidase(s).	Thompson J, Hess S, Pikis A	J Biol Chem	10.1074/jbc.M310733200	2003	Amino Acid Sequence, Catalysis, Cell-Free System, Chromatography, Chromatography, High Pressure Liquid, Clostridium/enzymology/genetics, Cysteine/chemistry, Disaccharides/chemistry, Dithiothreitol/pharmacology, Electrophoresis, Polyacrylamide Gel, Fusobacterium/metabolism, Genome, Bacterial, Hydrogen-Ion Concentration, Hydrolysis, Kinetics, Manganese/chemistry/metabolism, Molecular Sequence Data, Mutagenesis, Site-Directed, NAD/metabolism, Operon, Protein Isoforms, Proteome, Recombinant Proteins/metabolism, Sequence Homology, Amino Acid, Spectrometry, Mass, Electrospray Ionization, Spectrophotometry, Substrate Specificity, Sucrose/chemistry, Time Factors, alpha-Glucosidases/chemistry/*genetics/metabolism	Metabolism
Metabolism	14593248	Analysis of the elements of catabolite repression in Clostridium acetobutylicum ATCC 824.	Tangney M, Galinier A, Deutscher J, Mitchell WJ	J Mol Microbiol Biotechnol	10.1159/000073403	2003	Amino Acid Sequence, Bacterial Proteins/genetics/metabolism, Cloning, Molecular, Clostridium/genetics/metabolism, DNA-Binding Proteins/genetics/metabolism, *Genes, Bacterial, Molecular Sequence Data, Phosphoenolpyruvate Sugar Phosphotransferase System/genetics/metabolism, Phosphorylation, Phylogeny, Repressor Proteins/genetics/metabolism, Sequence Homology, Amino Acid	Enzymology
Metabolism	14679247	Production of heterologous and chimeric scaffoldins by Clostridium acetobutylicum ATCC 824.	Perret S, Casalot L, Fierobe HP, Tardif C, Sabathe F, Belaich JP, Belaich A	J Bacteriol	10.1128/JB.186.1.253-257.2004	2004	Bacterial Proteins/genetics/metabolism, Biotechnology/methods, Carrier Proteins/genetics/metabolism, Cellulase/genetics/metabolism, Cellulose/metabolism, Clostridium/genetics/metabolism, Membrane Proteins/genetics/metabolism, Recombinant Fusion Proteins/genetics/metabolism, Recombinant Proteins/genetics/*metabolism	Biotechnology
Genetics	15060177	Transcriptional organization of the Clostridium acetobutylicum genome.	Paredes CJ, Rigoutsos I, Papoutsakis ET	Nucleic Acids Res	10.1093/nar/gkh509	2004	Chromosome Mapping, Clostridium/genetics, Computational Biology/methods, Genome, Bacterial, Promoter Regions, Genetic, Reproducibility of Results, *Transcription, Genetic
Enzymology	15252718	Thermostable xylanase10B from Clostridium acetobutylicum ATCC824.	Ali MK, Rudolph FB, Bennett GN	J Ind Microbiol Biotechnol	10.1007/s10295-004-0143-8	2004	Cloning, Molecular, Clostridium/enzymology/genetics, Endo-1,4-beta Xylanases/genetics/metabolism, Enzyme Stability, Escherichia coli/enzymology/genetics, Hydrogen-Ion Concentration, Recombinant Proteins/isolation & purification/metabolism, Substrate Specificity, Temperature, Xylans/chemistry/metabolism	Metabolism
Enzymology	15280011	Identification of O2-induced peptides in an obligatory anaerobe, Clostridium acetobutylicum.	Kawasaki S, Ishikura J, Watamura Y, Niimura Y	FEBS Lett	10.1016/j.febslet.2004.06.047	2004	Amino Acid Sequence, Bacteria, Anaerobic/metabolism, Bacterial Proteins, Clostridium/drug effects/growth & development/metabolism, Electrophoresis, Gel, Two-Dimensional, Ferredoxins, Genome, Bacterial, Hemerythrin, Kinetics, Molecular Sequence Data, Molecular Weight, Multigene Family, Oxygen/pharmacology, Peptides/chemistry/*genetics/isolation & purification, Rubredoxins, Sequence Alignment, Sequence Homology, Amino Acid, Transcription, Genetic	Genetics
Metabolism	15345405	Substrate-induced production and secretion of cellulases by Clostridium acetobutylicum.	Lopez-Contreras AM, Gabor K, Martens AA, Renckens BA, Claassen PA, Van Der Oost J, De Vos WM	Appl Environ Microbiol	10.1128/AEM.70.9.5238-5243.2004	2004	Bacterial Proteins/genetics/metabolism, Base Sequence, Cellulase/biosynthesis/metabolism, Clostridium/enzymology, DNA Primers, Polymerase Chain Reaction, Recombinant Proteins/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Substrate Specificity	Biotechnology
Genetics	15743939	SpoIIE regulates sporulation but does not directly affect solventogenesis in Clostridium acetobutylicum ATCC 824.	Scotcher MC, Bennett GN	J Bacteriol	10.1128/JB.187.6.1930-1936.2005	2005	Bacterial Proteins/genetics/metabolism, Base Sequence, Clostridium acetobutylicum/enzymology/genetics/growth & development, Fermentation/physiology, Gene Expression Regulation, Bacterial, Genes, Reporter/genetics, Industrial Microbiology, Molecular Sequence Data, Phosphoric Monoester Hydrolases/genetics/metabolism, Promoter Regions, Genetic/genetics, RNA, Antisense, Solvents/metabolism, Spores, Bacterial/*physiology	Metabolism
Metabolism	15746321	Heterologous production, assembly, and secretion of a minicellulosome by Clostridium acetobutylicum ATCC 824.	Mingardon F, Perret S, Belaich A, Tardif C, Belaich JP, Fierobe HP	Appl Environ Microbiol	10.1128/AEM.71.3.1215-1222.2005	2005	Bacterial Proteins/biosynthesis/genetics, Carrier Proteins/biosynthesis/genetics, Cellulase/biosynthesis/genetics, Cellulose/metabolism, Cloning, Molecular, Clostridium acetobutylicum/genetics/metabolism, Gene Expression, Genes, Bacterial, Mannosidases/biosynthesis/genetics, Multienzyme Complexes/*biosynthesis/genetics, Operon, Recombinant Proteins/biosynthesis/genetics	Enzymology
Enzymology	15765251	Characterization of thermostable Xyn10A enzyme from mesophilic Clostridium acetobutylicum ATCC 824.	Ali MK, Rudolph FB, Bennett GN	J Ind Microbiol Biotechnol	10.1007/s10295-004-0192-z	2005	Amino Acid Sequence, Cloning, Molecular, Clostridium acetobutylicum/enzymology/genetics, Hot Temperature, Hydrogen-Ion Concentration, Molecular Sequence Data, Recombinant Proteins/genetics, Xylan Endo-1,3-beta-Xylosidase/genetics/metabolism, Xylose/metabolism	Stress
Metabolism	15812030	Expression of abrB310 and SinR, and effects of decreased abrB310 expression on the transition from acidogenesis to solventogenesis, in Clostridium acetobutylicum ATCC 824.	Scotcher MC, Rudolph FB, Bennett GN	Appl Environ Microbiol	10.1128/AEM.71.4.1987-1995.2005	2005	Acetates/metabolism, Acetone/metabolism, Amino Acid Sequence, Bacterial Proteins/chemistry/genetics/metabolism, Butanols/metabolism, Butyrates/metabolism, Clostridium acetobutylicum/genetics/growth & development/metabolism/physiology, DNA-Binding Proteins/chemistry/genetics/metabolism, Gene Expression Regulation, Bacterial, Molecular Sequence Data, Spores, Bacterial/physiology, Transcription Factors/chemistry/genetics/*metabolism	Genetics
Biotechnology	15869963	Secretory production of biologically active rat interleukin-2 by Clostridium acetobutylicum DSM792 as a tool for anti-tumor treatment.	Barbe S, Van Mellaert L, Theys J, Geukens N, Lammertyn E, Lambin P, Anne J	FEMS Microbiol Lett	10.1016/j.femsle.2005.03.037	2005	Animals, Artificial Gene Fusion, Cellulase/genetics, Clostridium acetobutylicum/genetics/metabolism, DNA, Complementary, Interleukin-2/biosynthesis/genetics/*immunology, Promoter Regions, Genetic, Protein Sorting Signals, Rats, Recombinant Fusion Proteins/biosynthesis/genetics/immunology	Metabolism
Enzymology	15870373	Homologous and heterologous overexpression in Clostridium acetobutylicum and characterization of purified clostridial and algal Fe-only hydrogenases with high specific activities.	Girbal L, von Abendroth G, Winkler M, Benton PM, Meynial-Salles I, Croux C, Peters JW, Happe T, Soucaille P	Appl Environ Microbiol	10.1128/AEM.71.5.2777-2781.2005	2005	Chlorophyta/enzymology, Clostridium acetobutylicum/genetics, Electron Spin Resonance Spectroscopy, Hydrogenase/genetics/isolation & purification/metabolism, Iron-Sulfur Proteins/genetics/isolation & purification/metabolism, Recombinant Proteins/*biosynthesis	Phylogeny
Metabolism	15950297	Genomic analysis of the protein secretion systems in Clostridium acetobutylicum ATCC 824.	Desvaux M, Khan A, Scott-Tucker A, Chaudhuri RR, Pallen MJ, Henderson IR	Biochim Biophys Acta	10.1016/j.bbamcr.2005.04.006	2005	Amino Acid Sequence, Antigens, Bacterial/genetics/metabolism, Bacterial Proteins/genetics/metabolism, Cellulosomes/physiology, Choline/metabolism, Clostridium acetobutylicum/enzymology/*genetics/physiology, Fimbriae Proteins/physiology, Molecular Sequence Data, Protein Binding/physiology, Protein Sorting Signals/genetics, Protein Structure, Tertiary, Protein Transport/physiology, Ricin/genetics/metabolism	Genetics
Enzymology	16187099	Biochemical characterization of trinitrotoluene transforming oxygen-insensitive nitroreductases from Clostridium acetobutylicum ATCC 824.	Kutty R, Bennett GN	Arch Microbiol	10.1007/s00203-005-0036-x	2005	Amino Acid Sequence, Cloning, Molecular, Clostridium acetobutylicum/enzymology/genetics, Dicumarol/pharmacology, Dinitrobenzenes/metabolism, Drug Resistance, Neoplasm, Enzyme Inhibitors/pharmacology, Escherichia coli Proteins/metabolism, Flavoproteins/chemistry, Gene Expression, Kinetics, Molecular Sequence Data, Molecular Weight, NAD/metabolism, NADP/metabolism, Nitro Compounds/metabolism, Nitrofurantoin/pharmacology, Nitrofurazone/pharmacology, Nitroreductases/chemistry/isolation & purification/metabolism, Recombinant Proteins/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Salicylamides/pharmacology, Spectrum Analysis, Substrate Specificity, Trinitrotoluene/*metabolism	Metabolism
Proteome	16308714	Proteome analysis and comparison of Clostridium acetobutylicum ATCC 824 and Spo0A strain variants.	Sullivan L, Bennett GN	J Ind Microbiol Biotechnol	10.1007/s10295-005-0050-7	2005	Bacterial Proteins/analysis/genetics, Clostridium acetobutylicum/genetics/metabolism, Electrophoresis, Gel, Two-Dimensional, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Mutation, Oligonucleotide Array Sequence Analysis, Proteome/analysis/genetics, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	Enzymology
Biotechnology	16346149	Acetone and Butanol Production by Clostridium acetobutylicum in a Synthetic Medium.	Monot F, Martin JR, Petitdemange H, Gay R	Appl Environ Microbiol	10.1128/aem.44.6.1318-1324.1982	1982
Biotechnology	16346258	Butanol Production by a Butanol-Tolerant Strain of Clostridium acetobutylicum in Extruded Corn Broth.	Lin YL, Blaschek HP	Appl Environ Microbiol	10.1128/aem.45.3.966-973.1983	1983
Biotechnology	16346678	Production of Solvents by Clostridium acetobutylicum Cultures Maintained at Neutral pH.	Holt RA, Stephens GM, Morris JG	Appl Environ Microbiol	10.1128/aem.48.6.1166-1170.1984	1984
	16346847	Cellulolytic Activity of Clostridium acetobutylicum.	Lee SF, Forsberg CW, Gibbins LN	Appl Environ Microbiol	10.1128/aem.50.2.220-228.1985	1985
	16346904	Xylanolytic Activity of Clostridium acetobutylicum.	Lee SF, Forsberg CW, Gibbins LN	Appl Environ Microbiol	10.1128/aem.50.4.1068-1076.1985	1985
	16347081	Influence of External pH and Fermentation Products on Clostridium acetobutylicum Intracellular pH and Cellular Distribution of Fermentation Products.	Huang L, Forsberg CW, Gibbins LN	Appl Environ Microbiol	10.1128/aem.51.6.1230-1234.1986	1986
Enzymology	16347312	Purification and Characterization of Two Endoxylanases from Clostridium acetobutylicum ATCC 824.	Lee SF, Forsberg CW, Rattray JB	Appl Environ Microbiol	10.1128/aem.53.4.644-650.1987	1987
Phylogeny	16347313	Isolation and Some Properties of a beta-d-Xylosidase from Clostridium acetobutylicum ATCC 824.	Lee SF, Forsberg CW	Appl Environ Microbiol	10.1128/aem.53.4.651-654.1987	1987
	16347502	Effect of Butanol Challenge and Temperature on Lipid Composition and Membrane Fluidity of Butanol-Tolerant Clostridium acetobutylicum.	Baer SH, Blaschek HP, Smith TL	Appl Environ Microbiol	10.1128/aem.53.12.2854-2861.1987	1987
	16347774	Thiolase from Clostridium acetobutylicum ATCC 824 and Its Role in the Synthesis of Acids and Solvents.	Wiesenborn DP, Rudolph FB, Papoutsakis ET	Appl Environ Microbiol	10.1128/aem.54.11.2717-2722.1988	1988
Enzymology	16347898	Isolation and Characterization of Mutants of Clostridium acetobutylicum ATCC 824 Deficient in Acetoacetyl-Coenzyme A:Acetate/Butyrate:Coenzyme A-Transferase (EC 2.8.3.9) and in Other Solvent Pathway Enzymes.	Clark SW, Bennett GN, Rudolph FB	Appl Environ Microbiol	10.1128/aem.55.4.970-976.1989	1989		Phylogeny
	16348040	Electron Spin Resonance Analysis of the Effect of Butanol on the Membrane Fluidity of Intact Cells of Clostridium acetobutylicum.	Baer SH, Bryant DL, Blaschek HP	Appl Environ Microbiol	10.1128/aem.55.10.2729-2731.1989	1989
Phylogeny	16349119	Isolation of a Degeneration-Resistant Mutant of Clostridium acetobutylicum NCIMB 8052.	Kashket ER, Cao ZY	Appl Environ Microbiol	10.1128/aem.59.12.4198-4202.1993	1993
Enzymology	16349164	Intracellular Concentrations of Coenzyme A and Its Derivatives from Clostridium acetobutylicum ATCC 824 and Their Roles in Enzyme Regulation.	Boynton ZL, Bennett GN, Rudolph FB	Appl Environ Microbiol	10.1128/aem.60.1.39-44.1994	1994
Metabolism	16427113	Biological hydrogen production by Clostridium acetobutylicum in an unsaturated flow reactor.	Zhang H, Bruns MA, Logan BE	Water Res	10.1016/j.watres.2005.11.041	2006	Animals, Bioelectric Energy Sources, Biofilms, Bioreactors, Clostridium acetobutylicum/metabolism, Fermentation, Glucose/metabolism, Hydrogen, Waste Disposal, Fluid	Biotechnology
Metabolism	16550436	Studies on inhibition of transformation of 2,4,6-trinitrotoluene catalyzed by Fe-only hydrogenase from Clostridium acetobutylicum.	Kutty R, Bennett GN	J Ind Microbiol Biotechnol	10.1007/s10295-005-0067-y	2006	Clostridium acetobutylicum/enzymology, Hydrogenase/chemistry/metabolism, Iron-Sulfur Proteins/chemistry/metabolism, Metronidazole/metabolism, Models, Molecular, Protein Conformation, Trinitrotoluene/metabolism	Enzymology
Cultivation	16855236	Transcription of the pst operon of Clostridium acetobutylicum is dependent on phosphate concentration and pH.	Fischer RJ, Oehmcke S, Meyer U, Mix M, Schwarz K, Fiedler T, Bahl H	J Bacteriol	10.1128/JB.00491-06	2006	Base Sequence, Clostridium acetobutylicum/genetics/growth & development, Culture Media, DNA, Bacterial, DNA, Intergenic/genetics, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Genes, Bacterial, Hydrogen-Ion Concentration, Molecular Sequence Data, Nucleic Acid Conformation, Operon/genetics, Phosphates, RNA, Bacterial/genetics, RNA, Messenger/genetics, Transcription Initiation Site	Genetics
	16887617	Characterisation of a transposon-induced pleiotropic mutant of Clostridium acetobutylicum P262.	Collett HJ, Woods DR, Reid SJ	Anaerobe	10.1006/anae.1997.0127	1997
Metabolism	17089149	Characterization of a novel ferredoxin with N-terminal extension from Clostridium acetobutylicum ATCC 824.	Kutty R, Bennett GN	Arch Microbiol	10.1007/s00203-006-0184-7	2006	Amino Acid Sequence, Clostridium acetobutylicum/chemistry, Electron Transport, Escherichia coli/genetics, Ferredoxins/chemistry/isolation & purification, Genes, Bacterial, Iron-Sulfur Proteins/chemistry/metabolism, Molecular Sequence Data, Trinitrotoluene/*metabolism	Genetics
Metabolism	17096120	Characterisation of a glucose phosphotransferase system in Clostridium acetobutylicum ATCC 824.	Tangney M, Mitchell WJ	Appl Microbiol Biotechnol	10.1007/s00253-006-0679-9	2006	Amino Acid Sequence, Base Sequence, Clostridium acetobutylicum/enzymology/genetics/growth & development, Glucose/metabolism, Industrial Microbiology/methods, Molecular Sequence Data, Phosphoenolpyruvate Sugar Phosphotransferase System/chemistry/genetics/*metabolism, Sequence Analysis, DNA	Genetics
Enzymology	17098314	A Standard Operating Procedure (SOP) for the preparation of intra- and extracellular proteins of Clostridium acetobutylicum for proteome analysis.	Schwarz K, Fiedler T, Fischer RJ, Bahl H	J Microbiol Methods	10.1016/j.mimet.2006.09.018	2006	Bacterial Proteins/isolation & purification, Cell Fractionation/methods, Chemical Precipitation, Clostridium acetobutylicum/chemistry, Electrophoresis, Gel, Two-Dimensional/methods, Proteomics/methods, Sonication, Ultrafiltration	Proteome
Metabolism	17209069	Analysis of the mechanism and regulation of lactose transport and metabolism in Clostridium acetobutylicum ATCC 824.	Yu Y, Tangney M, Aass HC, Mitchell WJ	Appl Environ Microbiol	10.1128/AEM.02082-06	2007	Amino Acid Sequence, Bacterial Proteins/genetics/metabolism, Biological Transport, Clostridium acetobutylicum/genetics/growth & development/metabolism, Gene Expression Regulation, Bacterial, Genome, Bacterial, Glucose/metabolism, Glycoside Hydrolases/genetics/metabolism, Lac Operon, Lactose/*metabolism, Molecular Sequence Data, Phosphoenolpyruvate Sugar Phosphotransferase System/genetics/metabolism, RNA, Bacterial/analysis/genetics, RNA, Messenger/analysis/genetics, Transcription Initiation Site, Transcription, Genetic	Genetics
Pathogenicity	17337545	Dynamics of genomic-library enrichment and identification of solvent tolerance genes for Clostridium acetobutylicum.	Borden JR, Papoutsakis ET	Appl Environ Microbiol	10.1128/AEM.02296-06	2007	1-Butanol/toxicity, Chromatography, High Pressure Liquid, Clostridium acetobutylicum/drug effects/genetics/growth & development, DNA Primers, Gene Expression Regulation, Bacterial/genetics, Genes, Bacterial/genetics, *Genomic Library, Microarray Analysis, Spectrophotometry
Phylogeny	17526797	A general framework for designing and validating oligomer-based DNA microarrays and its application to Clostridium acetobutylicum.	Paredes CJ, Senger RS, Spath IS, Borden JR, Sillers R, Papoutsakis ET	Appl Environ Microbiol	10.1128/AEM.00144-07	2007	Clostridium acetobutylicum/genetics, Gene Expression Profiling/methods, Nucleic Acid Hybridization, Oligonucleotide Array Sequence Analysis/*methods, Oligonucleotide Probes/genetics, Sensitivity and Specificity	Transcriptome
Enzymology	17933911	Engineered synthetic pathway for isopropanol production in Escherichia coli.	Hanai T, Atsumi S, Liao JC	Appl Environ Microbiol	10.1128/AEM.01140-07	2007	2-Propanol/metabolism, Acetyl-CoA C-Acetyltransferase/genetics, Alcohol Oxidoreductases/genetics, Bacterial Proteins/genetics, Biosynthetic Pathways, Carboxy-Lyases/genetics, Cloning, Molecular, Clostridium acetobutylicum/enzymology/genetics, Clostridium beijerinckii/enzymology/genetics, Escherichia coli/enzymology/genetics/metabolism, Gene Expression, Thermoanaerobacter/enzymology/genetics	Biotechnology
Metabolism	17987288	Production of isopropanol by metabolically engineered Escherichia coli.	Jojima T, Inui M, Yukawa H	Appl Microbiol Biotechnol	10.1007/s00253-007-1246-8	2007	2-Propanol/analysis/metabolism, Acetic Acid/metabolism, Alcohol Dehydrogenase/genetics/metabolism, Bacterial Proteins/genetics/metabolism, Bioreactors, Biosynthetic Pathways, Carboxy-Lyases/genetics/metabolism, Cloning, Molecular, Coenzyme A-Transferases/genetics/metabolism, Escherichia coli/genetics/metabolism, Genetic Engineering/methods, *Industrial Microbiology	Enzymology
Metabolism	18060402	Expression of Clostridium acetobutylicum butanol synthetic genes in Escherichia coli.	Inui M, Suda M, Kimura S, Yasuda K, Suzuki H, Toda H, Yamamoto S, Okino S, Suzuki N, Yukawa H	Appl Microbiol Biotechnol	10.1007/s00253-007-1257-5	2007	3-Hydroxyacyl CoA Dehydrogenases/genetics/metabolism, Acetyl-CoA C-Acetyltransferase/genetics/metabolism, Acyl Coenzyme A/genetics/metabolism, Alcohol Oxidoreductases/genetics/metabolism, Aldehyde Oxidoreductases/genetics/metabolism, Biosynthetic Pathways, Butanols/metabolism, Butyryl-CoA Dehydrogenase/genetics/metabolism, Clostridium acetobutylicum/enzymology/genetics, Escherichia coli/genetics, *Genes, Bacterial, Genetic Engineering, Recombinant Proteins/genetics/metabolism	Enzymology
Metabolism	18461320	Biosynthesis of enantiopure (S)-3-hydroxybutyric acid in metabolically engineered Escherichia coli.	Lee SH, Park SJ, Lee SY, Hong SH	Appl Microbiol Biotechnol	10.1007/s00253-008-1473-7	2008	3-Hydroxyacyl CoA Dehydrogenases/genetics/metabolism, 3-Hydroxybutyric Acid/chemistry/metabolism, Acetyl-CoA C-Acyltransferase/genetics/metabolism, Bacillus cereus/enzymology, Bacterial Proteins/genetics/metabolism, Biomass, Bioreactors, Biosynthetic Pathways, Clostridium acetobutylicum/enzymology, Cupriavidus necator/enzymology, Escherichia coli/chemistry/genetics/metabolism, Genetic Engineering, Glucose/metabolism, *Industrial Microbiology, Thiolester Hydrolases/genetics/metabolism	Enzymology
Metabolism	18491597	[Extracellular glycosyl hydrolase activity of the clostridia producing acetone, butanol, and ethanol].	Berezina OV, Sineokii SP, Velikodvorskaia GA, Schwarz W, Zverlov VV	Prikl Biokhim Mikrobiol		2008	Acetic Acid/metabolism, Acetone/metabolism, Butanols/metabolism, Butyric Acid/metabolism, Carboxymethylcellulose Sodium/metabolism, Cellulose/metabolism, Clostridium acetobutylicum/classification/growth & development/metabolism, Crystallins/metabolism, Ethanol/metabolism, Hydrolases/*metabolism, Xylans/metabolism, beta-Glucans/metabolism	Phylogeny
Physiology	18561223	Systems analysis of the culture physiology in acetone-butanol fermentation.	Yerushalmi L, Volesky B, Votruba J	Biotechnol Bioeng	10.1002/bit.260280908	1986
	18588047	Acetone-butanol-ethanol (ABE) fermentation in an immobilized cell trickle bed reactor.	Park CH, Okos MR, Wankat PC	Biotechnol Bioeng	10.1002/bit.260340104	1989
	18588169	Effects of pH and added metabolites on bioconversions by immobilized non-growing Clostridium acetobutylicum.	Reardon KF, Bailey JE	Biotechnol Bioeng	10.1002/bit.260340612	1989
Biotechnology	18613233	Metabolic engineering of Clostridium acetobutylicum ATCC 824 for increased solvent production by enhancement of acetone formation enzyme activities using a synthetic acetone operon.	Mermelstein LD, Papoutsakis ET, Petersen DJ, Bennett GN	Biotechnol Bioeng	10.1002/bit.260420906	1993		Enzymology
Metabolism	18689481	The two-component system PhoPR of Clostridium acetobutylicum is involved in phosphate-dependent gene regulation.	Fiedler T, Mix M, Meyer U, Mikkat S, Glocker MO, Bahl H, Fischer RJ	J Bacteriol	10.1128/JB.00574-08	2008	Amino Acid Sequence, Bacterial Proteins/biosynthesis/genetics, Base Sequence, Clostridium acetobutylicum/physiology, DNA, Bacterial/metabolism, Electrophoresis, Gel, Two-Dimensional, Electrophoretic Mobility Shift Assay, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Gene Order, Molecular Sequence Data, Phosphates/metabolism, Phosphorylation, Promoter Regions, Genetic, Protein Binding, Sequence Alignment, Signal Transduction, Transcription Initiation Site	Enzymology
Metabolism	18758767	Genome-scale reconstruction and in silico analysis of the Clostridium acetobutylicum ATCC 824 metabolic network.	Lee J, Yun H, Feist AM, Palsson BO, Lee SY	Appl Microbiol Biotechnol	10.1007/s00253-008-1654-4	2008	1-Butanol/metabolism, Biomass, Clostridium acetobutylicum/genetics/metabolism, Computational Biology, Computer Simulation, Genome, Bacterial, Metabolic Networks and Pathways, *Models, Biological	Genetics
Metabolism	18767191	Genome-scale model for Clostridium acetobutylicum: Part II. Development of specific proton flux states and numerically determined sub-systems.	Senger RS, Papoutsakis ET	Biotechnol Bioeng	10.1002/bit.22009	2008	Acids/analysis/metabolism, Alanine Racemase/metabolism, Biomass, Cell Growth Processes/genetics, Clostridium acetobutylicum/growth & development/metabolism, Computational Biology/methods, D-Alanine Transaminase/metabolism, Extracellular Fluid/chemistry, Fermentation/physiology, Hydrogen-Ion Concentration, Ion Transport/physiology, Kinetics, Metabolic Networks and Pathways/genetics, Metabolome/physiology, Models, Biological, Protons, Signal Transduction, Systems Integration, Transaminases/metabolism	Enzymology
Metabolism	18767192	Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis.	Senger RS, Papoutsakis ET	Biotechnol Bioeng	10.1002/bit.22010	2008	Arginine/biosynthesis, Cell Growth Processes/genetics, Clostridium acetobutylicum/genetics/growth & development/metabolism, Computational Biology/methods, Gene Knockout Techniques, Genome, Bacterial/physiology, Glutamic Acid/analysis/metabolism, Kinetics, Metabolic Networks and Pathways/genetics, *Models, Biological, Ornithine/biosynthesis, Phosphotransferases (Carboxyl Group Acceptor)/genetics/metabolism, Thermodynamics, Transaminases/analysis/metabolism, Urea/metabolism	Genetics
Metabolism	18831001	In situ product recovery of n-butanol using polymeric resins.	Nielsen DR, Prather KJ	Biotechnol Bioeng	10.1002/bit.22109	2009	1-Butanol/metabolism, Adsorption, Bioreactors, Clostridium acetobutylicum/metabolism, Energy-Generating Resources, Escherichia coli/metabolism, Fermentation, Glucose/metabolism, Industrial Microbiology/methods, Polymers, *Resins, Synthetic	Biotechnology
Metabolism	19695296	Improvement of xylose utilization in Clostridium acetobutylicum via expression of the talA gene encoding transaldolase from Escherichia coli.	Gu Y, Li J, Zhang L, Chen J, Niu L, Yang Y, Yang S, Jiang W	J Biotechnol	10.1016/j.jbiotec.2009.08.009	2009	Cell Culture Techniques/methods, Clostridium acetobutylicum/enzymology/genetics/metabolism, Culture Media, Escherichia coli/enzymology/genetics, Escherichia coli Proteins/biosynthesis/genetics/metabolism, Fermentation, Gene Expression, Glucose/metabolism, Solvents/metabolism, Transaldolase/biosynthesis/genetics/metabolism, Xylose/metabolism	Enzymology
Metabolism	19798472	Development of real-time PCR primer and probe sets for detecting degenerated and non-degenerated forms of the butanol-producing bacterium Clostridium acetobutylicum ATCC 824.	Lee SM, Cho MO, Um Y, Sang BI	Appl Biochem Biotechnol	10.1007/s12010-009-8788-4	2009	Butanols/metabolism, Clostridium acetobutylicum/genetics/metabolism, DNA Primers/genetics, DNA Probes/genetics, Fermentation/genetics, Polymerase Chain Reaction/*methods, Sensitivity and Specificity
Metabolism	19830716	Metabolic engineering of Clostridium acetobutylicum M5 for highly selective butanol production.	Lee JY, Jang YS, Lee J, Papoutsakis ET, Lee SY	Biotechnol J	10.1002/biot.200900142	2009	Acetone/metabolism, Alcohol Dehydrogenase/genetics/metabolism, Biotechnology/methods, Butanols/metabolism, Clostridium acetobutylicum/enzymology/genetics/*metabolism, Coenzyme A-Transferases/genetics/metabolism, Hydrogen-Ion Concentration	Biotechnology
Metabolism	19915043	Tertiary structure and characterization of a glycoside hydrolase family 44 endoglucanase from Clostridium acetobutylicum.	Warner CD, Hoy JA, Shilling TC, Linnen MJ, Ginder ND, Ford CF, Honzatko RB, Reilly PJ	Appl Environ Microbiol	10.1128/AEM.02026-09	2009	Carboxymethylcellulose Sodium/metabolism, Cellulase/chemistry/genetics/isolation & purification/metabolism, Cellulose/analogs & derivatives/metabolism, Clostridium acetobutylicum/*enzymology/genetics, Crystallization, Crystallography, X-Ray, Enzyme Stability, Escherichia coli/genetics, Gene Expression, Glucans/metabolism, Glucose/metabolism, Hydrogen-Ion Concentration, Kinetics, Models, Molecular, Oligosaccharides/metabolism, Phylogeny, Protein Structure, Tertiary, Recombinant Proteins/chemistry/isolation & purification, Sequence Homology, Amino Acid, Substrate Specificity, Temperature, Tetroses/metabolism, Transformation, Genetic, Xylans/metabolism	Enzymology
Metabolism	20060060	A genomic-library based discovery of a novel, possibly synthetic, acid-tolerance mechanism in Clostridium acetobutylicum involving non-coding RNAs and ribosomal RNA processing.	Borden JR, Jones SW, Indurthi D, Chen Y, Papoutsakis ET	Metab Eng	10.1016/j.ymben.2009.12.004	2010	Clostridium acetobutylicum/genetics, Gene Expression, Gene Library, Genetic Loci, Genomic Library, Promoter Regions, Genetic, RNA, RNA Precursors/metabolism, RNA, Antisense/metabolism, RNA, Ribosomal, Ribosomes/metabolism
Metabolism	20478391	Identification and inactivation of pleiotropic regulator CcpA to eliminate glucose repression of xylose utilization in Clostridium acetobutylicum.	Ren C, Gu Y, Hu S, Wu Y, Wang P, Yang Y, Yang C, Yang S, Jiang W	Metab Eng	10.1016/j.ymben.2010.05.002	2010	Bacterial Proteins/physiology, Clostridium acetobutylicum/physiology, Genetic Enhancement/methods, Genetic Pleiotropy/genetics, Glucose/metabolism, Repressor Proteins/genetics, Xylose/*metabolism
Enzymology	20889336	Continuous lactose fermentation by Clostridium acetobutylicum--assessment of acidogenesis kinetics.	Napoli F, Olivieri G, Russo ME, Marzocchella A, Salatino P	Bioresour Technol	10.1016/j.biortech.2010.09.004	2010	Acetic Acid/pharmacology, Acids/metabolism, Butyric Acid/pharmacology, Clostridium acetobutylicum/drug effects/growth & development/metabolism, Culture Media/pharmacology, Fermentation/drug effects/physiology, Hydrogen-Ion Concentration/drug effects, Kinetics, Lactose/metabolism, Models, Biological, Solvents/pharmacology	Metabolism
Biotechnology	20931261	Improving the Clostridium acetobutylicum butanol fermentation by engineering the strain for co-production of riboflavin.	Cai X, Bennett GN	J Ind Microbiol Biotechnol	10.1007/s10295-010-0875-6	2010	Amino Acid Sequence, Biotechnology, Butanols/metabolism, Clostridium acetobutylicum/genetics/metabolism, Escherichia coli/genetics, Fermentation, Genetic Engineering, Genetic Vectors/genetics, Molecular Sequence Data, Plasmids/genetics, Riboflavin/*metabolism	Metabolism
Metabolism	21284892	Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018.	Hu S, Zheng H, Gu Y, Zhao J, Zhang W, Yang Y, Wang S, Zhao G, Yang S, Jiang W	BMC Genomics	10.1186/1471-2164-12-93	2011	Butanols/metabolism, Clostridium acetobutylicum/genetics/metabolism, Gene Expression Profiling/methods, Genome, Bacterial/genetics, Xylose/metabolism	Genetics
Metabolism	21335380	D-2,3-butanediol production due to heterologous expression of an acetoin reductase in Clostridium acetobutylicum.	Siemerink MA, Kuit W, Lopez Contreras AM, Eggink G, van der Oost J, Kengen SW	Appl Environ Microbiol	10.1128/AEM.01616-10	2011	Alcohol Oxidoreductases/genetics/metabolism, Biofuels/microbiology, Butylene Glycols/metabolism, Chromatography, High Pressure Liquid, Clostridium acetobutylicum/genetics/metabolism, Clostridium beijerinckii/genetics, Fermentation, Gas Chromatography-Mass Spectrometry, Gene Expression, Genetic Engineering, Promoter Regions, Genetic, Stereoisomerism	Enzymology
Metabolism	21370473	Resolving the TCA cycle and pentose-phosphate pathway of Clostridium acetobutylicum ATCC 824: Isotopomer analysis, in vitro activities and expression analysis.	Crown SB, Indurthi DC, Ahn WS, Choi J, Papoutsakis ET, Antoniewicz MR	Biotechnol J	10.1002/biot.201000282	2010	Citric Acid Cycle, Clostridium acetobutylicum/genetics/metabolism, Gene Expression Profiling, Glucose/metabolism, Glycolysis, Ketoglutaric Acids/metabolism, *Pentose Phosphate Pathway, Solvents
Enzymology	21378034	The issue of secretion in heterologous expression of Clostridium cellulolyticum cellulase-encoding genes in Clostridium acetobutylicum ATCC 824.	Mingardon F, Chanal A, Tardif C, Fierobe HP	Appl Environ Microbiol	10.1128/AEM.03012-10	2011	Cellulase/genetics/metabolism, Cloning, Molecular, Clostridium acetobutylicum/genetics/metabolism, Clostridium cellulolyticum/*enzymology/genetics, Culture Media/chemistry, Cytoplasm/enzymology, Gene Expression, Genetic Vectors, Plasmids, Protein Sorting Signals, Recombinant Proteins/genetics/metabolism, Sequence Deletion	Metabolism
Metabolism	21421765	Inactivation of sigmaF in Clostridium acetobutylicum ATCC 824 blocks sporulation prior to asymmetric division and abolishes sigmaE and sigmaG protein expression but does not block solvent formation.	Jones SW, Tracy BP, Gaida SM, Papoutsakis ET	J Bacteriol	10.1128/JB.00088-11	2011	Acetone/metabolism, Butanols/metabolism, Clostridium acetobutylicum/genetics/growth & development/metabolism, Gene Expression Regulation, Bacterial, Gene Knockout Techniques, Genetic Complementation Test, Sigma Factor/genetics/metabolism, Spores, Bacterial/genetics/growth & development
Metabolism	21530675	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production.	Yu M, Zhang Y, Tang IC, Yang ST	Metab Eng	10.1016/j.ymben.2011.04.002	2011	1-Butanol/metabolism, Acetate Kinase/biosynthesis/genetics, Bacterial Proteins/biosynthesis/genetics, Clostridium acetobutylicum/enzymology/genetics, Clostridium tyrobutyricum/enzymology/genetics/growth & development, Gene Expression, Gene Knockdown Techniques, Mannitol/metabolism/pharmacology, *Organisms, Genetically Modified/genetics/growth & development/metabolism, Oxidoreductases/biosynthesis/genetics, Phosphate Acetyltransferase/biosynthesis/genetics, Sweetening Agents/metabolism/pharmacology	Enzymology
Genetics	21742891	Complete genome sequence of Clostridium acetobutylicum DSM 1731, a solvent-producing strain with multireplicon genome architecture.	Bao G, Wang R, Zhu Y, Dong H, Mao S, Zhang Y, Chen Z, Li Y, Ma Y	J Bacteriol	10.1128/JB.05596-11	2011	Clostridium acetobutylicum/genetics/metabolism, DNA, Bacterial/chemistry/genetics, Genome, Bacterial, Molecular Sequence Data, Mutagenesis, Insertional, Plasmids, *Sequence Analysis, DNA, Solvents/metabolism	Metabolism
Metabolism	21784928	SpoIIE is necessary for asymmetric division, sporulation, and expression of sigmaF, sigmaE, and sigmaG but does not control solvent production in Clostridium acetobutylicum ATCC 824.	Bi C, Jones SW, Hess DR, Tracy BP, Papoutsakis ET	J Bacteriol	10.1128/JB.05474-11	2011	Bacterial Proteins/genetics/metabolism, Blotting, Southern, Blotting, Western, Clostridium acetobutylicum/genetics/growth & development/metabolism, Gene Expression Regulation, Bacterial/genetics/physiology, Microscopy, Phase-Contrast, Reverse Transcriptase Polymerase Chain Reaction, Sigma Factor/genetics/metabolism, Spores, Bacterial/genetics/*metabolism	Biotechnology
Metabolism	21925629	Biotransformation of furfural and 5-hydroxymethyl furfural (HMF) by Clostridium acetobutylicum ATCC 824 during butanol fermentation.	Zhang Y, Han B, Ezeji TC	N Biotechnol	10.1016/j.nbt.2011.09.001	2011	Biotransformation/drug effects/physiology, Butanols/metabolism, Clostridium acetobutylicum/growth & development, Furaldehyde/analogs & derivatives/metabolism, Lignin/*metabolism/pharmacology	Pathogenicity
Metabolism	21926197	Confirmation and elimination of xylose metabolism bottlenecks in glucose phosphoenolpyruvate-dependent phosphotransferase system-deficient Clostridium acetobutylicum for simultaneous utilization of glucose, xylose, and arabinose.	Xiao H, Gu Y, Ning Y, Yang Y, Mitchell WJ, Jiang W, Yang S	Appl Environ Microbiol	10.1128/AEM.00644-11	2011	Acetone/metabolism, Aldose-Ketose Isomerases/biosynthesis, Arabinose/metabolism, Butanols/metabolism, Clostridium acetobutylicum/enzymology/genetics/metabolism, Ethanol/metabolism, Fermentation, Gene Expression, Gene Knockout Techniques, Glucose/metabolism, Lignin/metabolism, Metabolic Networks and Pathways/genetics, Organisms, Genetically Modified/metabolism, Phosphoenolpyruvate Sugar Phosphotransferase System/deficiency, Phosphotransferases (Alcohol Group Acceptor)/biosynthesis, Symporters/biosynthesis, Xylose/*metabolism	Enzymology
Biotechnology	21974878	Continuous acetone-butanol-ethanol fermentation using SO2-ethanol-water spent liquor from spruce.	Survase SA, Sklavounos E, Jurgens G, van Heiningen A, Granstrom T	Bioresour Technol	10.1016/j.biortech.2011.09.034	2011	Acetone/chemistry, Bioreactors, Biotechnology/methods, Butanols/chemistry, Clostridium acetobutylicum/metabolism, Ethanol/chemistry, Fermentation, Glucose/chemistry, Solvents/chemistry, Sulfur Dioxide/*chemistry, Time Factors, Trees, Waste Disposal, Fluid/methods, Water/chemistry, Wood	Metabolism
	22008648	Comparative shotgun proteomic analysis of Clostridium acetobutylicum from butanol fermentation using glucose and xylose.	Sivagnanam K, Raghavan VG, Shah M, Hettich RL, Verberkmoes NC, Lefsrud MG	Proteome Sci	10.1186/1477-5956-9-66	2011
Metabolism	22024446	DENSE: efficient and prior knowledge-driven discovery of phenotype-associated protein functional modules.	Hendrix W, Rocha AM, Padmanabhan K, Choudhary A, Scott K, Mihelcic JR, Samatova NF	BMC Syst Biol	10.1186/1752-0509-5-172	2011	Animals, Binding Sites, Cattle, Cell Movement, Cells, Cultured, Computer Simulation, Extracellular Matrix/metabolism, Fibronectins/metabolism, Humans, Models, Biological, Neuropilin-1/metabolism, Pancreatic Elastase/metabolism, Phenotype, Rats, Receptors, Vascular Endothelial Growth Factor/metabolism, Signal Transduction, Systems Biology, Vascular Endothelial Growth Factor A/chemistry/*metabolism/physiology	Phenotype
Metabolism	22038854	Improving fatty acid production in Escherichia coli through the overexpression of malonyl coA-acyl carrier protein transacylase.	Zhang X, Agrawal A, San KY	Biotechnol Prog	10.1002/btpr.716	2011	Acyl-Carrier Protein S-Malonyltransferase/genetics/metabolism, Amino Acid Sequence, Clostridium acetobutylicum/enzymology/genetics, DNA Primers, Escherichia coli/enzymology/genetics, Escherichia coli Proteins/genetics/metabolism, Fatty Acid Synthase, Type II/genetics/metabolism, Fatty Acids/*biosynthesis, Gene Expression Regulation, Bacterial, Malonyl Coenzyme A/metabolism, Molecular Sequence Data, Plasmids, Streptomyces/enzymology/genetics	Enzymology
Metabolism	22159612	Continuous bio-catalytic conversion of sugar mixture to acetone-butanol-ethanol by immobilized Clostridium acetobutylicum DSM 792.	Survase SA, van Heiningen A, Granstrom T	Appl Microbiol Biotechnol	10.1007/s00253-011-3761-x	2011	Acetone/metabolism, Bioreactors/microbiology, Biotransformation, Butanols/metabolism, Cells, Immobilized/metabolism, Clostridium acetobutylicum/metabolism, Ethanol/metabolism, Fermentation, Industrial Microbiology, Monosaccharides/*metabolism	Biotechnology
Metabolism	22179241	An agr quorum sensing system that regulates granulose formation and sporulation in Clostridium acetobutylicum.	Steiner E, Scott J, Minton NP, Winzer K	Appl Environ Microbiol	10.1128/AEM.06376-11	2011	Bacterial Proteins/genetics/metabolism, Clostridium acetobutylicum/genetics/growth & development/metabolism, Gene Deletion, Gene Expression Regulation, Bacterial, Genetic Complementation Test, Polysaccharides/metabolism, Quorum Sensing, Spores, Bacterial/growth & development
Metabolism	22210214	Metabolic engineering of Clostridium acetobutylicum ATCC 824 for isopropanol-butanol-ethanol fermentation.	Lee J, Jang YS, Choi SJ, Im JA, Song H, Cho JH, Seung do Y, Papoutsakis ET, Bennett GN, Lee SY	Appl Environ Microbiol	10.1128/AEM.06382-11	2011	2-Propanol/metabolism, Acetone/metabolism, Alcohol Dehydrogenase/genetics/metabolism, Biofuels, Butanols/metabolism, Clostridium acetobutylicum/enzymology/genetics/metabolism, Clostridium beijerinckii/enzymology/genetics, Ethanol/metabolism, Fermentation, Metabolic Engineering, Recombinant Proteins/genetics/metabolism	Enzymology
Metabolism	22213682	Reaction engineering studies of acetone-butanol-ethanol fermentation with Clostridium acetobutylicum.	Schmidt M, Weuster-Botz D	Biotechnol J	10.1002/biot.201100418	2012	Acetone/metabolism, Ammonia/metabolism, Anaerobiosis, Bioengineering/methods, Biofuels, Bioreactors/microbiology, Butanols/metabolism, Clostridium acetobutylicum/metabolism, Culture Media/chemistry/metabolism, Ethanol/*metabolism, Fermentation, Glucose/metabolism, Pilot Projects	Biotechnology
Metabolism	22246530	Modifying the product pattern of Clostridium acetobutylicum: physiological effects of disrupting the acetate and acetone formation pathways.	Lehmann D, Honicke D, Ehrenreich A, Schmidt M, Weuster-Botz D, Bahl H, Lutke-Eversloh T	Appl Microbiol Biotechnol	10.1007/s00253-011-3852-8	2012	Acetates/metabolism, Acetone/metabolism, Butyrates/metabolism, Clostridium acetobutylicum/genetics/metabolism, Ethanol/metabolism, Fermentation, Gene Deletion, Metabolic Engineering/methods, Metabolic Networks and Pathways/genetics
Metabolism	22277213	Acetone-butanol fermentation of marine macroalgae.	Huesemann MH, Kuo LJ, Urquhart L, Gill GA, Roesijadi G	Bioresour Technol	10.1016/j.biortech.2011.12.148	2012	Acetone/metabolism, Butanols/metabolism, Chromatography, High Pressure Liquid, Clostridium acetobutylicum/growth & development/metabolism, Complex Mixtures/chemistry, Fermentation, Glucans, Glucose/analysis/metabolism, Industrial Microbiology/economics/methods, Mannitol/analysis/metabolism, Phaeophyta/chemistry, Polysaccharides/analysis/*metabolism	Biotechnology
Metabolism	22305171	Continuous lactose fermentation by Clostridium acetobutylicum--assessment of energetics and product yields of the acidogenesis.	Napoli F, Olivieri G, Russo ME, Marzocchella A, Salatino P	Enzyme Microb Technol	10.1016/j.enzmictec.2011.11.003	2011	Acetates/metabolism/pharmacology, Adenosine Triphosphate/metabolism, Biomass, Bioreactors, Biotechnology/methods, Butyrates/metabolism/pharmacology, Clostridium acetobutylicum/growth & development/metabolism, Culture Media, Fermentation, Hydrogen-Ion Concentration, Kinetics, Lactose/metabolism, Models, Biological, Solvents/*metabolism/pharmacology	Biotechnology
Metabolism	22306328	Novel and neglected issues of acetone-butanol-ethanol (ABE) fermentation by clostridia: Clostridium metabolic diversity, tools for process mapping and continuous fermentation systems.	Patakova P, Linhova M, Rychtera M, Paulova L, Melzoch K	Biotechnol Adv	10.1016/j.biotechadv.2012.01.010	2012	Acetone/metabolism, Butanols/metabolism, Clostridium/cytology/genetics/metabolism, Ethanol/metabolism, *Fermentation, Flow Cytometry, Glycerol/metabolism, Hexoses/metabolism, Inulin/metabolism, Lactose/metabolism, Oligonucleotide Array Sequence Analysis, Pentoses/metabolism, Spectroscopy, Fourier Transform Infrared, Spectrum Analysis, Raman	Transcriptome
Metabolism	22395897	Shotgun proteomic monitoring of Clostridium acetobutylicum during stationary phase of butanol fermentation using xylose and comparison with the exponential phase.	Sivagnanam K, Raghavan VG, Shah M, Hettich RL, Verberkmoes NC, Lefsrud MG	J Ind Microbiol Biotechnol	10.1007/s10295-012-1094-0	2012	Butanols/metabolism, Clostridium acetobutylicum/genetics/growth & development/metabolism, Fermentation, Gene Expression Profiling, Industrial Microbiology, Proteomics/methods, Xylose/metabolism	Biotechnology
Cultivation	22406098	Integrated bioprocess for long-term continuous cultivation of Clostridium acetobutylicum coupled to pervaporation with PDMS composite membranes.	Van Hecke W, Vandezande P, Claes S, Vangeel S, Beckers H, Diels L, De Wever H	Bioresour Technol	10.1016/j.biortech.2012.02.043	2012	Clostridium acetobutylicum/growth & development/metabolism, Dimethylpolysiloxanes, Fermentation	Metabolism
Genetics	22446850	Resonance assignments of cohesin and dockerin domains from Clostridium acetobutylicum ATCC824.	Cui Z, Li Y, Xiao Y, Feng Y, Cui Q	Biomol NMR Assign	10.1007/s12104-012-9381-2	2012	Bacterial Proteins/chemistry, Cell Cycle Proteins/chemistry, Cellulosomes/metabolism, Chromosomal Proteins, Non-Histone/chemistry, Clostridium acetobutylicum/cytology, *Nuclear Magnetic Resonance, Biomolecular, Protein Structure, Tertiary	Metabolism
Metabolism	22576944	The redox-sensing protein Rex, a transcriptional regulator of solventogenesis in Clostridium acetobutylicum.	Wietzke M, Bahl H	Appl Microbiol Biotechnol	10.1007/s00253-012-4112-2	2012	Acetic Acid/metabolism, Acetone/metabolism, Butanols/metabolism, Butyric Acid/metabolism, Clostridium acetobutylicum/genetics/metabolism, Ethanol/metabolism, Gene Deletion, Gene Expression Regulation, Bacterial, Metabolic Networks and Pathways/genetics, Mutagenesis, Insertional, NAD/metabolism, Oxidation-Reduction, Transcription Factors/*metabolism
Enzymology	22583864	Genome-scale modeling using flux ratio constraints to enable metabolic engineering of clostridial metabolism in silico.	McAnulty MJ, Yen JY, Freedman BG, Senger RS	BMC Syst Biol	10.1186/1752-0509-6-42	2012	Alcohol Oxidoreductases/deficiency/genetics, Aldehyde Oxidoreductases/deficiency/genetics, Algorithms, Bacterial Proteins/genetics, Clostridium acetobutylicum/enzymology/genetics/metabolism, Coenzyme A-Transferases/deficiency/genetics, Computational Biology/methods, Gene Knockdown Techniques, Genome, Bacterial/genetics, Metabolic Engineering/methods, Metabolic Networks and Pathways, *Models, Biological, Multienzyme Complexes/deficiency/genetics, RNA, Antisense/genetics	Metabolism
Metabolism	22627760	Phosphoproteomic investigation of a solvent producing bacterium Clostridium acetobutylicum.	Bai X, Ji Z	Appl Microbiol Biotechnol	10.1007/s00253-012-4156-3	2012	Amino Acid Sequence, Bacterial Proteins/metabolism, Biotechnology, Chromatography, Liquid, Clostridium acetobutylicum/growth & development/metabolism, Mass Spectrometry, Molecular Sequence Data, Phosphoproteins/chemistry/metabolism, Phosphorylation, Proteome, Proteomics/methods, Solvents/*metabolism	Biotechnology
Metabolism	22776992	Engineering a homobutanol fermentation pathway in Escherichia coli EG03.	Garza E, Zhao J, Wang Y, Wang J, Iverson A, Manow R, Finan C, Zhou S	J Ind Microbiol Biotechnol	10.1007/s10295-012-1151-8	2012	1-Butanol/metabolism, 3-Hydroxyacyl CoA Dehydrogenases/genetics/metabolism, Acetyl-CoA C-Acetyltransferase/genetics/metabolism, Alcohol Dehydrogenase/genetics/metabolism, Biofuels, Bioreactors, Butanols/metabolism, Butyryl-CoA Dehydrogenase/genetics/metabolism, Clostridium acetobutylicum/enzymology/genetics, Enoyl-CoA Hydratase/genetics/metabolism, Escherichia coli/classification/genetics/metabolism, Fermentation, Glucose/metabolism, Glycolysis, Metabolic Engineering, NAD/metabolism, Oxidation-Reduction, Pyruvate Dehydrogenase Complex/genetics/metabolism	Enzymology
Enzymology	22803344	[Cloning and expression of key genes of butanol synthetic pathway in Escherichia coli].	Zhang Y, Zhou P, Wang P, Xie J, Ye Q	Wei Sheng Wu Xue Bao		2012	1-Butanol/metabolism, Cloning, Molecular, Clostridium acetobutylicum/enzymology/genetics/metabolism, Escherichia coli/enzymology/genetics/metabolism, Escherichia coli Proteins/biosynthesis/*genetics/metabolism, Fermentation, Recombinant Proteins/biosynthesis/genetics/metabolism	Metabolism
Metabolism	22843424	Analysis of redox responses during TNT transformation by Clostridium acetobutylicum ATCC 824 and mutants exhibiting altered metabolism.	Cai X, Servinsky M, Kiel J, Sund C, Bennett GN	Appl Microbiol Biotechnol	10.1007/s00253-012-4253-3	2012	Base Sequence, Clostridium acetobutylicum/genetics/metabolism, Colorimetry, DNA Primers, Fermentation, Hydrolysis, Oxidation-Reduction, Plasmids, Trinitrotoluene/metabolism
Biotechnology	22909015	Simultaneous production of isopropanol, butanol, ethanol and 2,3-butanediol by Clostridium acetobutylicum ATCC 824 engineered strains.	Collas F, Kuit W, Clement B, Marchal R, Lopez-Contreras AM, Monot F	AMB Express	10.1186/2191-0855-2-45	2012
Metabolism	22922942	Arabinose is metabolized via a phosphoketolase pathway in Clostridium acetobutylicum ATCC 824.	Servinsky MD, Germane KL, Liu S, Kiel JT, Clark AM, Shankar J, Sund CJ	J Ind Microbiol Biotechnol	10.1007/s10295-012-1186-x	2012	Aldehyde-Lyases/metabolism, Arabinose/metabolism, Clostridium acetobutylicum/enzymology/genetics/*metabolism, Fructose/metabolism, Gene Expression Regulation, Bacterial/drug effects, Glucose/metabolism, Pentose Phosphate Pathway, RNA, Messenger/genetics/metabolism, Time Factors, Xylose/metabolism	Enzymology
Enzymology	22982601	Targeted mutagenesis of the Clostridium acetobutylicum acetone-butanol-ethanol fermentation pathway.	Cooksley CM, Zhang Y, Wang H, Redl S, Winzer K, Minton NP	Metab Eng	10.1016/j.ymben.2012.09.001	2012	Acetone/isolation & purification/metabolism, Butanols/isolation & purification/metabolism, Clostridium acetobutylicum, Ethanol/isolation & purification/metabolism, Fermentation, Gene Silencing, Genetic Enhancement/methods, Multienzyme Complexes/physiology, Mutagenesis, Site-Directed/methods, Signal Transduction/*physiology	Phylogeny
Metabolism	23023236	Yeast extract promotes phase shift of bio-butanol fermentation by Clostridium acetobutylicum ATCC824 using cassava as substrate.	Li X, Li Z, Zheng J, Shi Z, Li L	Bioresour Technol	10.1016/j.biortech.2012.08.056	2012	Biofuels/microbiology, Bioreactors/microbiology, Butanols/isolation & purification/metabolism, Clostridium acetobutylicum/chemistry/metabolism, Fermentation, Manihot/microbiology	Enzymology
Metabolism	23069614	Characterization of a butanol-acetone-producing Clostridium strain and identification of its solventogenic genes.	Chua TK, Liang DW, Qi C, Yang KL, He J	Bioresour Technol	10.1016/j.biortech.2012.08.085	2012	Acetone/metabolism, Alcohol Dehydrogenase/chemistry, Amino Acid Motifs, Base Sequence, Butanols/metabolism, Clostridium acetobutylicum/enzymology/genetics/isolation & purification/metabolism, Fatty Acids, Volatile/biosynthesis, Gene Expression Regulation, Bacterial/drug effects, Genes, Bacterial/genetics, Glucose/pharmacology, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, 16S/genetics, Sequence Alignment, Sequence Analysis, DNA, Solvents/*metabolism	Phylogeny
Metabolism	23085417	Improved efficiency of butanol production by absorbed lignocellulose fermentation.	He Q, Chen H	J Biosci Bioeng	10.1016/j.jbiosc.2012.09.017	2012	Absorption, Acetone/metabolism, Butanols/metabolism, Cellulase/metabolism, Clostridium acetobutylicum/metabolism, Ethanol/metabolism, Fermentation, Glucose/metabolism, Lignin/*metabolism, Steam, Xylose/metabolism, Zea mays/chemistry/metabolism	Biotechnology
Metabolism	23096577	Thiolase engineering for enhanced butanol production in Clostridium acetobutylicum.	Mann MS, Lutke-Eversloh T	Biotechnol Bioeng	10.1002/bit.24758	2012	Acetone/metabolism, Acetyl-CoA C-Acetyltransferase/genetics/metabolism, Amino Acid Substitution, Butanols/metabolism, Clostridium acetobutylicum/enzymology/genetics, DNA Mutational Analysis, Escherichia coli/genetics/metabolism, Ethanol/metabolism, Gene Expression, High-Throughput Screening Assays, *Metabolic Engineering	Biotechnology
Metabolism	23274997	Effects of nutritional enrichment on the production of acetone-butanol-ethanol (ABE) by Clostridium acetobutylicum.	Choi SJ, Lee J, Jang YS, Park JH, Lee SY, Kim IH	J Microbiol	10.1007/s12275-012-2373-1	2012	Acetone/metabolism, Biofuels, Butanols/metabolism, Clostridium acetobutylicum/growth & development/metabolism, Ethanol/*metabolism, Fermentation	Biotechnology
Metabolism	23523702	Workflow for quantitative proteomic analysis of Clostridium acetobutylicum ATCC 824 using iTRAQ tags.	Hou S, Jones SW, Choe LH, Papoutsakis ET, Lee KH	Methods	10.1016/j.ymeth.2013.03.013	2013	Amino Acid Sequence, Bacterial Proteins/chemistry/isolation & purification/metabolism, Bioreactors, Butanols/pharmacology, Calcium Carbonate/chemistry, Chromatography, Liquid, Clostridium acetobutylicum/chemistry/drug effects/growth & development/metabolism, Fermentation, Molecular Sequence Annotation, Molecular Sequence Data, Peptides/chemistry/isolation & purification/metabolism, Proteome/chemistry/isolation & purification/metabolism, Proteomics/*methods, Stress, Physiological, Tandem Mass Spectrometry, Workflow	Enzymology
Metabolism	23524105	New options to engineer biofuel microbes: development and application of a high-throughput screening system.	Scheel M, Lutke-Eversloh T	Metab Eng	10.1016/j.ymben.2013.03.002	2013	1-Butanol/metabolism, Bacterial Proteins/genetics/metabolism, Biofuels/microbiology, Biological Assay/methods, Clostridium acetobutylicum/isolation & purification/physiology, Ethanol/metabolism, Mutagenesis, Site-Directed/*methods	Enzymology
Metabolism	23541907	Metabolic engineering of Clostridium acetobutylicum ATCC 824 for the high-yield production of a biofuel composed of an isopropanol/butanol/ethanol mixture.	Dusseaux S, Croux C, Soucaille P, Meynial-Salles I	Metab Eng	10.1016/j.ymben.2013.03.003	2013	2-Propanol/metabolism, Biofuels, Butanols/metabolism, Clostridium acetobutylicum/genetics/growth & development/metabolism, Ethanol/metabolism, Hydrogen-Ion Concentration, Metabolic Engineering, Operon/genetics, Plasmids/genetics	Biotechnology
Metabolism	23619138	Butanol production by bioconversion of cheese whey in a continuous packed bed reactor.	Raganati F, Olivieri G, Procentese A, Russo ME, Salatino P, Marzocchella A	Bioresour Technol	10.1016/j.biortech.2013.03.180	2013	Acids/metabolism, Biofilms, Biomass, Bioreactors/microbiology, Biotechnology/instrumentation/methods, Butanols/metabolism, Cheese, Clostridium acetobutylicum/growth & development/metabolism, Milk Proteins/metabolism, Whey Proteins	Biotechnology
Biotechnology	23674152	Metabolic engineering of Candida utilis for isopropanol production.	Tamakawa H, Mita T, Yokoyama A, Ikushima S, Yoshida S	Appl Microbiol Biotechnol	10.1007/s00253-013-4964-0	2013	2-Propanol/metabolism, Acetates/metabolism, Candida/genetics/*metabolism, Fermentation, Industrial Microbiology, Metabolic Engineering	Metabolism
Metabolism	23708785	The two stage immobilized column reactor with an integrated solvent recovery module for enhanced ABE production.	Bankar SB, Survase SA, Ojamo H, Granstrom T	Bioresour Technol	10.1016/j.biortech.2013.04.046	2013	Acetone/metabolism, Bioreactors/microbiology, Biotechnology/instrumentation/methods, Butanols/metabolism, Carbohydrate Metabolism, Cells, Immobilized, Clostridium acetobutylicum/cytology/metabolism, Ethanol/metabolism, Fermentation, Liquid-Liquid Extraction, Solvents/*isolation & purification, Time Factors	Biotechnology
Metabolism	23838793	Enhanced butanol production in Clostridium acetobutylicum ATCC 824 by double overexpression of 6-phosphofructokinase and pyruvate kinase genes.	Ventura JR, Hu H, Jahng D	Appl Microbiol Biotechnol	10.1007/s00253-013-5075-7	2013	Acetone/metabolism, Adenosine Triphosphate/metabolism, Biotechnology/methods, Butanols/metabolism, Clostridium acetobutylicum/genetics/metabolism, Ethanol/metabolism, Gene Expression, Glucose/metabolism, Metabolic Engineering/methods, NAD/metabolism, Phosphofructokinase-1/biosynthesis/genetics, Pyruvate Kinase/*biosynthesis/genetics	Biotechnology
	23962085	Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824.	Kovacs K, Willson BJ, Schwarz K, Heap JT, Jackson A, Bolam DN, Winzer K, Minton NP	Biotechnol Biofuels	10.1186/1754-6834-6-117	2013
Metabolism	24076145	Engineering a synthetic pathway in cyanobacteria for isopropanol production directly from carbon dioxide and light.	Kusakabe T, Tatsuke T, Tsuruno K, Hirokawa Y, Atsumi S, Liao JC, Hanai T	Metab Eng	10.1016/j.ymben.2013.09.007	2013	2-Propanol/metabolism, Bacterial Proteins/genetics/metabolism, Carbon Dioxide/metabolism, Clostridium acetobutylicum/enzymology/genetics, Clostridium beijerinckii/enzymology/genetics, Escherichia coli K12/enzymology/genetics, Light, Metabolic Engineering, Recombinant Proteins/genetics/metabolism, *Synechococcus/genetics/metabolism	Enzymology
Metabolism	24114460	Acetone-butanol-ethanol production from corn stover pretreated by alkaline twin-screw extrusion pretreatment.	Zhang Y, Hou T, Li B, Liu C, Mu X, Wang H	Bioprocess Biosyst Eng	10.1007/s00449-013-1063-7	2013	Acetone/metabolism, Butanols/metabolism, Clostridium acetobutylicum/growth & development/metabolism, Culture Media/chemistry, Ethanol/metabolism, Zea mays/chemistry	Biotechnology
Metabolism	24504855	In situ butanol recovery from Clostridium acetobutylicum fermentations by expanded bed adsorption.	Wiehn M, Staggs K, Wang Y, Nielsen DR	Biotechnol Prog	10.1002/btpr.1841	2013	Adsorption, Biofuels, Bioreactors/microbiology, Biotechnology/instrumentation/methods, Butanols/analysis/metabolism, Clostridium acetobutylicum/*metabolism, Equipment Design, Fermentation	Biotechnology
Metabolism	24510404	Promotion of the Clostridium acetobutylicum ATCC 824 growth and acetone-butanol-ethanol fermentation by flavonoids.	Wang L, Xia M, Zhang L, Chen H	World J Microbiol Biotechnol	10.1007/s11274-014-1619-y	2014	Acetone/metabolism, Biomass, Butanols/metabolism, Clostridium acetobutylicum/drug effects/metabolism, Ethanol/metabolism, Fermentation/drug effects, Flavonoids/pharmacology	Pathogenicity
Phylogeny	24600866	Evaluation of hydrogen production by clostridium strains on beet molasses.	Avci A, Kilic NK, Donmez G, Donmez S	Environ Technol	10.1080/09593330.2013.826251	2014	Beta vulgaris/microbiology, Biofuels/microbiology, Clostridium/classification/isolation & purification/physiology, Hydrogen/isolation & purification/metabolism, Molasses/*microbiology, Species Specificity	Enzymology
Metabolism	24697168	Feasibility study on microencapsulation of anaerobic Clostridium acetobutylicum ATCC 824 by emulsification method for application in biobutanol production.	Rathore S, Heng PW, Chan LW	J Microencapsul	10.3109/02652048.2013.879928	2014	1-Butanol/metabolism, Cells, Immobilized/cytology/metabolism, Clostridium acetobutylicum/cytology/metabolism, Drug Compounding, Emulsions/chemistry, Feasibility Studies, Fermentation, Industrial Microbiology/methods, Polysaccharides, Bacterial/chemistry, Spores, Bacterial/cytology/metabolism	Biotechnology
Metabolism	24743985	Proteomic analyses of the phase transition from acidogenesis to solventogenesis using solventogenic and non-solventogenic Clostridium acetobutylicum strains.	Jang YS, Han MJ, Lee J, Im JA, Lee YH, Papoutsakis ET, Bennett G, Lee SY	Appl Microbiol Biotechnol	10.1007/s00253-014-5738-z	2014	Acetic Acid/metabolism, Bacterial Proteins/analysis, Butanols/metabolism, Clostridium acetobutylicum/chemistry/growth & development/metabolism, Proteome/analysis	Proteome
Metabolism	24841119	Identification of PTS(Fru) as the major fructose uptake system of Clostridium acetobutylicum.	Voigt C, Bahl H, Fischer RJ	Appl Microbiol Biotechnol	10.1007/s00253-014-5809-1	2014	Carbon/metabolism, Clostridium acetobutylicum/enzymology/genetics/metabolism, Culture Media/chemistry, Fermentation, Fructose/metabolism, Gene Knockout Techniques, Phosphoenolpyruvate Sugar Phosphotransferase System/genetics/metabolism	Enzymology
Metabolism	24852648	Continuous xylose fermentation by Clostridium acetobutylicum--kinetics and energetics issues under acidogenesis conditions.	Procentese A, Raganati F, Olivieri G, Russo ME, Salatino P, Marzocchella A	Bioresour Technol	10.1016/j.biortech.2014.04.054	2014	Acetic Acid/metabolism, Acids/metabolism, Biomass, Butyric Acid/metabolism, Clostridium acetobutylicum/growth & development/metabolism, Fermentation, Kinetics, Solvents, Xylose/metabolism	Enzymology
Phylogeny	25046159	Engineering Clostridium acetobutylicum for production of kerosene and diesel blendstock precursors.	Bormann S, Baer ZC, Sreekumar S, Kuchenreuther JM, Dean Toste F, Blanch HW, Clark DS	Metab Eng	10.1016/j.ymben.2014.07.003	2014	Alcohol Oxidoreductases/genetics/metabolism, Aldehyde Dehydrogenase/genetics/metabolism, Bacterial Proteins/physiology, Biofuels/microbiology, Clostridium acetobutylicum/classification/physiology, Gasoline/microbiology, Genetic Enhancement/methods, Kerosene/microbiology, Metabolic Engineering/*methods, Species Specificity	Biotechnology
Biotechnology	25118402	[Effect of non-ionic surfactants on butanol production with Clostridium acetobutylicum ATCC 824].	Hou T, Zhang Y, Chen X, Guan J, Mu X	Sheng Wu Gong Cheng Xue Bao		2014	Acetone/chemistry, Bioreactors, Butanols/chemistry, Clostridium acetobutylicum/metabolism, Ethanol/chemistry, Fermentation, Surface-Active Agents/chemistry	Metabolism
Metabolism	25183671	Parallel labeling experiments validate Clostridium acetobutylicum metabolic network model for (13)C metabolic flux analysis.	Au J, Choi J, Jones SW, Venkataramanan KP, Antoniewicz MR	Metab Eng	10.1016/j.ymben.2014.08.002	2014	Bacterial Proteins/metabolism, Carbon-13 Magnetic Resonance Spectroscopy/methods, Citric Acid Cycle/physiology, Clostridium acetobutylicum/metabolism, Isotope Labeling, Metabolic Flux Analysis/methods, Models, Biological, Signal Transduction/physiology
Stress	25379054	Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model.	Dash S, Mueller TJ, Venkataramanan KP, Papoutsakis ET, Maranas CD	Biotechnol Biofuels	10.1186/s13068-014-0144-4	2014
Metabolism	25460988	Process development for biological production of butanol from Eastern redcedar.	Liu K, Atiyeh HK, Pardo-Planas O, Ramachandriya KD, Wilkins MR, Ezeji TC, Ujor V, Tanner RS	Bioresour Technol	10.1016/j.biortech.2014.10.148	2014	Biosynthetic Pathways/physiology, Biotechnology/methods, Butanols/metabolism, Charcoal, Clostridium acetobutylicum/metabolism/physiology, Clostridium beijerinckii/metabolism/physiology, Fermentation, Hydrogen-Ion Concentration, Juniperus/chemistry, Linear Models	Biotechnology
Metabolism	25496491	Saccharification of rice straw by cellulase from a local Trichoderma harzianum SNRS3 for biobutanol production.	Rahnama N, Foo HL, Abdul Rahman NA, Ariff A, Md Shah UK	BMC Biotechnol	10.1186/s12896-014-0103-y	2014	Biocatalysis, Biofuels/analysis, Butanols/metabolism, Cellulases/chemistry/isolation & purification, Cellulose/chemistry, Clostridium acetobutylicum/metabolism, Fermentation, Fungal Proteins/chemistry/isolation & purification, Hydrolysis, Oryza/chemistry/metabolism/microbiology, Plant Stems/chemistry/metabolism/microbiology, Trichoderma/chemistry/enzymology/genetics/isolation & purification, Waste Products/*analysis	Enzymology
Phylogeny	25557787	Acetone-butanol-ethanol production from substandard and surplus dates by Egyptian native Clostridium strains.	Abd-Alla MH, Zohri AA, El-Enany AE, Ali SM	Anaerobe	10.1016/j.anaerobe.2014.12.008	2014	Acetone/metabolism, Biofuels, Butanols/metabolism, Clostridium/classification/genetics/isolation & purification/metabolism, Ethanol/metabolism, *Fermentation, Genotype, Phenotype, Phylogeny, RNA, Ribosomal, 16S/genetics, Soil Microbiology	Metabolism
Metabolism	25761520	Microencapsulation of Clostridium acetobutylicum ATCC 824 spores in gellan gum microspheres for the production of biobutanol.	Rathore S, Wan Sia Heng P, Chan LW	J Microencapsul	10.3109/02652048.2015.1017617	2015	Butanols/metabolism, Cells, Immobilized/cytology/metabolism, Clostridium acetobutylicum/cytology/metabolism, Drug Compounding, Fermentation, Industrial Microbiology/methods, Microspheres, Polysaccharides, Bacterial/*chemistry	Biotechnology
Metabolism	25851718	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production: effects of CoA transferase.	Yu L, Zhao J, Xu M, Dong J, Varghese S, Yu M, Tang IC, Yang ST	Appl Microbiol Biotechnol	10.1007/s00253-015-6566-5	2015	1-Butanol/metabolism, Acetone/metabolism, Clostridium acetobutylicum/enzymology/genetics, Clostridium beijerinckii/enzymology/genetics, Clostridium tyrobutyricum/enzymology/genetics/metabolism, Coenzyme A-Transferases/genetics/metabolism, Fermentation, Gene Deletion, Gene Expression, Glucose/metabolism, Metabolic Engineering, Metabolic Networks and Pathways/*genetics, Plasmids	Enzymology
Genetics	25867337	Selectional versus mutational mechanism underlying genomic features of bacterial strand asymmetry: a case study in Clostridium acetobutylicum.	Zhao HL, Xia ZK, Hua ZG, Wei W	Genet Mol Res	10.4238/2015.March.20.1	2015	Clostridium acetobutylicum/genetics, DNA Replication, DNA, Bacterial/genetics, Escherichia coli/genetics, Genome, Bacterial, *Mutation, Open Reading Frames, Polymorphism, Single Nucleotide
Metabolism	25894463	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production through co-utilization of glucose and xylose.	Yu L, Xu M, Tang IC, Yang ST	Biotechnol Bioeng	10.1002/bit.25613	2015	1-Butanol/metabolism, Clostridium acetobutylicum/enzymology/genetics, Clostridium tyrobutyricum/enzymology/genetics/metabolism, Fermentation, Gene Deletion, Gene Expression, Glucose/metabolism, Metabolic Engineering/methods, Recombinant Proteins/genetics/metabolism, Soybeans/metabolism, Xylose/metabolism	Biotechnology
Metabolism	25943991	Feasibility of biohydrogen production from industrial wastes using defined microbial co-culture.	Chen P, Wang Y, Yan L, Wang Y, Li S, Yan X, Wang N, Liang N, Li H	Biol Res	10.1186/s40659-015-0015-x	2015	Carboxylic Acids/metabolism, Clostridium acetobutylicum/metabolism, Coculture Techniques, Electric Conductivity, Enterobacter cloacae/metabolism, Feasibility Studies, Fermentation/physiology, Hydrogen/analysis/metabolism, Industrial Waste, Ions/metabolism, Kluyveromyces/metabolism, Metals/metabolism, Microbial Consortia/physiology, Microbial Interactions/physiology, Renewable Energy, Starch/metabolism, Time Factors, Waste Water/analysis	Biotechnology
Metabolism	26002632	Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from maltose and soluble starch by overexpressing alpha-glucosidase.	Yu L, Xu M, Tang IC, Yang ST	Appl Microbiol Biotechnol	10.1007/s00253-015-6680-4	2015	1-Butanol/metabolism, Cloning, Molecular, Clostridium acetobutylicum/enzymology/genetics, Clostridium tyrobutyricum/genetics/metabolism, Gene Expression, Maltose/metabolism, Metabolic Engineering/methods, Starch/metabolism, alpha-Glucosidases/genetics/*metabolism	Enzymology
Metabolism	26014369	In situ hydrogen, acetone, butanol, ethanol and microdiesel production by Clostridium acetobutylicum ATCC 824 from oleaginous fungal biomass.	Hassan EA, Abd-Alla MH, Bagy MM, Morsy FM	Anaerobe	10.1016/j.anaerobe.2015.05.007	2015	Acetone/metabolism, Alcohols/metabolism, Anaerobiosis, Biofuels, Biomass, Biotransformation, Clostridium acetobutylicum/metabolism, Cunninghamella/growth & development, Hydrogen/*metabolism	Biotechnology
Metabolism	26026401	Butanol production from hexoses and pentoses by fermentation of Clostridium acetobutylicum.	Raganati F, Olivieri G, Gotz P, Marzocchella A, Salatino P	Anaerobe	10.1016/j.anaerobe.2015.05.008	2015	Batch Cell Culture Techniques, Biotransformation, Butanols/metabolism, Clostridium acetobutylicum, Culture Media/chemistry, Fermentation, Hexoses/metabolism, Pentoses/*metabolism	Biotechnology
	26089984	Developing a mesophilic co-culture for direct conversion of cellulose to butanol in consolidated bioprocess.	Wang Z, Cao G, Zheng J, Fu D, Song J, Zhang J, Zhao L, Yang Q	Biotechnol Biofuels	10.1186/s13068-015-0266-3	2015
Metabolism	26100881	Integrated, systems metabolic picture of acetone-butanol-ethanol fermentation by Clostridium acetobutylicum.	Liao C, Seo SO, Celik V, Liu H, Kong W, Wang Y, Blaschek H, Jin YS, Lu T	Proc Natl Acad Sci U S A	10.1073/pnas.1423143112	2015	Acetone/metabolism, Algorithms, Bacterial Proteins/genetics/metabolism, Biofuels, Butanols/metabolism, Clostridium acetobutylicum/genetics/metabolism, Computer Simulation, Ethanol/metabolism, *Fermentation, Gene Expression Regulation, Bacterial, Hydrogen-Ion Concentration, Kinetics, Models, Biological	Enzymology
Enzymology	26249707	Structural analysis of Clostridium acetobutylicum ATCC 824 glycoside hydrolase from CAZy family GH105.	Germane KL, Servinsky MD, Gerlach ES, Sund CJ, Hurley MM	Acta Crystallogr F Struct Biol Commun	10.1107/S2053230X15012121	2015	Amino Acid Motifs, Bacillus subtilis/chemistry/genetics, Bacterial Proteins/chemistry/genetics, Base Sequence, Catalytic Domain, Cloning, Molecular, Clostridium acetobutylicum/chemistry/genetics, Crystallization, Crystallography, X-Ray, Escherichia coli/genetics/metabolism, Gene Expression, Glycoside Hydrolases/chemistry/genetics, Models, Molecular, Molecular Sequence Data, Pectins/chemistry, Protein Binding, Protein Structure, Secondary, Protein Structure, Tertiary, Recombinant Fusion Proteins/*chemistry/genetics, Static Electricity, Structural Homology, Protein, Substrate Specificity	Genetics
Enzymology	26320708	Characterization of an acetoin reductase/2,3-butanediol dehydrogenase from Clostridium ljungdahlii DSM 13528.	Tan Y, Liu ZY, Liu Z, Li FL	Enzyme Microb Technol	10.1016/j.enzmictec.2015.06.011	2015	Acetoin/metabolism, Alcohol Oxidoreductases/chemistry/genetics/metabolism, Amino Acid Sequence, Bacterial Proteins/chemistry/genetics/metabolism, Butylene Glycols/metabolism, Clostridium/enzymology/genetics, Clostridium acetobutylicum/enzymology/genetics, Fermentation, Genes, Bacterial, Industrial Microbiology, Kinetics, Metabolic Engineering, Models, Molecular, Molecular Sequence Data, Phylogeny, Protein Conformation, Recombinant Proteins/chemistry/genetics/metabolism, Sequence Homology, Amino Acid	Metabolism
	26441884	Spontaneous large-scale autolysis in Clostridium acetobutylicum contributes to generation of more spores.	Liu Z, Qiao K, Tian L, Zhang Q, Liu ZY, Li FL	Front Microbiol	10.3389/fmicb.2015.00950	2015
Metabolism	26453472	Feasibility of installing and maintaining anaerobiosis using Escherichia coli HD701 as a facultative anaerobe for hydrogen production by Clostridium acetobutylicum ATCC 824 from various carbohydrates.	Hassan SH, Morsy FM	Enzyme Microb Technol	10.1016/j.enzmictec.2015.08.002	2015	Anaerobiosis, Biomass, Carbohydrate Metabolism, Clostridium acetobutylicum/metabolism, Escherichia coli/metabolism, Feasibility Studies, Fermentation, Hydrogen/*metabolism, Industrial Microbiology	Biotechnology
Metabolism	26650720	In silico analysis of Clostridium acetobutylicum ATCC 824 metabolic response to an external electron supply.	Gallardo R, Acevedo A, Quintero J, Paredes I, Conejeros R, Aroca G	Bioprocess Biosyst Eng	10.1007/s00449-015-1513-5	2015	Clostridium acetobutylicum/metabolism, Computer Simulation, Electrons, Models, Biological
	26702300	Periodic-peristole agitation for process enhancement of butanol fermentation.	Xia ML, Wang L, Yang ZX, Chen HZ	Biotechnol Biofuels	10.1186/s13068-015-0409-6	2015
	26732067	Mutant generation by allelic exchange and genome resequencing of the biobutanol organism Clostridium acetobutylicum ATCC 824.	Ehsaan M, Kuit W, Zhang Y, Cartman ST, Heap JT, Winzer K, Minton NP	Biotechnol Biofuels	10.1186/s13068-015-0410-0	2016
Enzymology	26814030	Raman spectroscopy detects phenotypic differences among Escherichia coli enriched for 1-butanol tolerance using a metagenomic DNA library.	Freedman BG, Zu TN, Wallace RS, Senger RS	Biotechnol J	10.1002/biot.201500144	2016	1-Butanol/pharmacology, Cloning, Molecular, Clostridium acetobutylicum/genetics, Escherichia coli/chemistry/drug effects/genetics/growth & development, Genes, Bacterial, Industrial Microbiology/methods, Metabolic Engineering/methods, Metagenome, Phenotype, Soil Microbiology, Spectrum Analysis, Raman, Transformation, Bacterial	Phenotype
Biotechnology	26839586	Construction of a restriction-less, marker-less mutant useful for functional genomic and metabolic engineering of the biofuel producer Clostridium acetobutylicum.	Croux C, Nguyen NP, Lee J, Raynaud C, Saint-Prix F, Gonzalez-Pajuelo M, Meynial-Salles I, Soucaille P	Biotechnol Biofuels	10.1186/s13068-016-0432-2	2016
Metabolism	27001972	Development of an inducible transposon system for efficient random mutagenesis in Clostridium acetobutylicum.	Zhang Y, Xu S, Chai C, Yang S, Jiang W, Minton NP, Gu Y	FEMS Microbiol Lett	10.1093/femsle/fnw065	2016	Acetone/metabolism, Butanols/metabolism, Clostridium acetobutylicum/genetics/metabolism, DNA Transposable Elements/genetics, Ethanol/metabolism, Fermentation/genetics, Mutagenesis/genetics, Spores, Bacterial/*genetics, Xylose/metabolism
Enzymology	27194524	Application to Photocatalytic H2 Production of a Whole-Cell Reaction by Recombinant Escherichia coli Cells Expressing [FeFe]-Hydrogenase and Maturases Genes.	Honda Y, Hagiwara H, Ida S, Ishihara T	Angew Chem Int Ed Engl	10.1002/anie.201600177	2016		Biotechnology
Metabolism	27212267	Periodic peristalsis increasing acetone-butanol-ethanol productivity during simultaneous saccharification and fermentation of steam-exploded corn straw.	Li J, Wang L, Chen H	J Biosci Bioeng	10.1016/j.jbiosc.2016.04.009	2016	1-Butanol/metabolism, Acetone/metabolism, Batch Cell Culture Techniques/methods, Butanols/metabolism, Carbohydrate Metabolism, Carbohydrates/analysis, Cellulase/metabolism, Clostridium acetobutylicum/enzymology/metabolism, Ethanol/metabolism, Fermentation, Lignin/chemistry/metabolism, Movement, Steam, Sucrose/metabolism, *Zea mays/chemistry/metabolism	Enzymology
Biotechnology	27213844	CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii.	Li Q, Chen J, Minton NP, Zhang Y, Wen Z, Liu J, Yang H, Zeng Z, Ren X, Yang J, Gu Y, Jiang W, Jiang Y, Yang S	Biotechnol J	10.1002/biot.201600053	2016	Bacterial Proteins/genetics, CRISPR-Cas Systems, Clostridium acetobutylicum/genetics, Clostridium beijerinckii/genetics, Deoxyribonuclease I/genetics, Gene Expression Regulation, Bacterial, Genetic Engineering/methods, Industrial Microbiology, Mutagenesis, Plasmids/genetics, RNA, Guide/genetics
Biotechnology	27222664	Production of a functional cell wall-anchored minicellulosome by recombinant Clostridium acetobutylicum ATCC 824.	Willson BJ, Kovacs K, Wilding-Steele T, Markus R, Winzer K, Minton NP	Biotechnol Biofuels	10.1186/s13068-016-0526-x	2016
Metabolism	27230401	Fermentation of residual glycerol by Clostridium acetobutylicum ATCC 824 in pure and mixed cultures.	Dams RI, Guilherme AA, Vale MS, Nunes VF, Leitao RC, Santaella ST	Environ Technol	10.1080/09593330.2016.1173114	2016	Acids, Acyclic/metabolism, Animals, Beer, Clostridium acetobutylicum/metabolism, Ethanol/metabolism, Fermentation, Gastrointestinal Contents, Glycerol/metabolism, Goats, Hydrogen/metabolism, Industrial Waste, Propylene Glycols/metabolism, Rumen, Sewage	Biotechnology
Biotechnology	27247624	Quantitative proteomic analysis of the influence of lignin on biofuel production by Clostridium acetobutylicum ATCC 824.	Raut MP, Couto N, Pham TK, Evans C, Noirel J, Wright PC	Biotechnol Biofuels	10.1186/s13068-016-0523-0	2016
Metabolism	27321153	A quantitative metabolomics study of high sodium response in Clostridium acetobutylicum ATCC 824 acetone-butanol-ethanol (ABE) fermentation.	Zhao X, Condruz S, Chen J, Jolicoeur M	Sci Rep	10.1038/srep28307	2016	Acetone/metabolism, Butanols/metabolism, Clostridium acetobutylicum/metabolism, Ethanol/metabolism, Metabolome/drug effects, Metabolomics, Sodium/metabolism/*pharmacology	Pathogenicity
Metabolism	27496775	Extending CRISPR-Cas9 Technology from Genome Editing to Transcriptional Engineering in the Genus Clostridium.	Bruder MR, Pyne ME, Moo-Young M, Chung DA, Chou CP	Appl Environ Microbiol	10.1128/AEM.02128-16	2016	Bacterial Proteins/genetics/metabolism, CRISPR-Cas Systems, Clostridium acetobutylicum/genetics/metabolism, Clustered Regularly Interspaced Short Palindromic Repeats, Gene Editing, Genetic Engineering/*methods, Genome, Bacterial, Transcription, Genetic	Genetics
Biotechnology	27878375	Hyper-thermal acid hydrolysis and adsorption treatment of red seaweed, Gelidium amansii for butyric acid production with pH control.	Ra CH, Jeong GT, Kim SK	Bioprocess Biosyst Eng	10.1007/s00449-016-1708-4	2016	Acids/chemistry, Adsorption, Bioreactors, Butyric Acid/chemistry, Carbon/chemistry, Clostridium acetobutylicum, Enzymes/chemistry, Ethanol/chemistry, Fermentation, Furaldehyde/analogs & derivatives, Hydrogen-Ion Concentration, Hydrolysis, Industrial Microbiology/methods, Seaweed/*metabolism, Temperature	Enzymology
Metabolism	27918147	Genome analysis of a hyper acetone-butanol-ethanol (ABE) producing Clostridium acetobutylicum BKM19.	Cho C, Choe D, Jang YS, Kim KJ, Kim WJ, Cho BK, Papoutsakis ET, Bennett GN, Seung DY, Lee SY	Biotechnol J	10.1002/biot.201600457	2017	Acetone/metabolism, Butanols/metabolism, Clostridium acetobutylicum/genetics/metabolism, Ethanol/metabolism, Genome, Bacterial/genetics	Genetics
Metabolism	28242562	Synergistic dark and photo-fermentation continuous system for hydrogen production from molasses by Clostridium acetobutylicum ATCC 824 and Rhodobacter capsulatus DSM 1710.	Morsy FM	J Photochem Photobiol B	10.1016/j.jphotobiol.2017.02.011	2017	Bioreactors/microbiology, Butanols/metabolism, Clostridium acetobutylicum/metabolism, Ethanol/metabolism, Fermentation, Hexoses/metabolism, Hydrogen/isolation & purification/metabolism, Molasses/microbiology, Rhodobacter capsulatus/*metabolism	Biotechnology
Pathogenicity	28450259	Improving cellular robustness and butanol titers of Clostridium acetobutylicum ATCC824 by introducing heat shock proteins from an extremophilic bacterium.	Liao Z, Zhang Y, Luo S, Suo Y, Zhang S, Wang J	J Biotechnol	10.1016/j.jbiotec.2017.04.031	2017	1-Butanol/pharmacology, Bacterial Proteins/genetics, Chaperonins/genetics, Clostridium acetobutylicum/drug effects/genetics/growth & development, Escherichia coli/genetics, Furaldehyde/pharmacology, Heat-Shock Proteins/*genetics, Hydrogen Peroxide/pharmacology, Hydrogen-Ion Concentration, Oxidants/pharmacology
Biotechnology	28474218	New Insight into Sugarcane Industry Waste Utilization (Press Mud) for Cleaner Biobutanol Production by Using C. acetobutylicum NRRL B-527.	Nimbalkar PR, Khedkar MA, Gaikwad SG, Chavan PV, Bankar SB	Appl Biochem Biotechnol	10.1007/s12010-017-2479-3	2017	Biotechnology/methods, Butanols/metabolism, Clostridium acetobutylicum/metabolism, Fermentation, Green Chemistry Technology, Hydrolysis, Industrial Waste, Saccharum/*chemistry	Metabolism
Metabolism	28610973	A two-plasmid inducible CRISPR/Cas9 genome editing tool for Clostridium acetobutylicum.	Wasels F, Jean-Marie J, Collas F, Lopez-Contreras AM, Lopes Ferreira N	J Microbiol Methods	10.1016/j.mimet.2017.06.010	2017	Bacterial Proteins/genetics, CRISPR-Cas Systems/genetics, Clostridium acetobutylicum/genetics/metabolism, Gene Deletion, Gene Editing/methods, Genetic Engineering/methods, Metabolic Engineering, Mutagenesis, Insertional, Plasmids
Biotechnology	28702083	Metabolic engineering of Rhodopseudomonas palustris for the obligate reduction of n-butyrate to n-butanol.	Doud DFR, Holmes EC, Richter H, Molitor B, Jander G, Angenent LT	Biotechnol Biofuels	10.1186/s13068-017-0864-3	2017
Metabolism	28853155	A dynamic metabolic flux analysis of ABE (acetone-butanol-ethanol) fermentation by Clostridium acetobutylicum ATCC 824, with riboflavin as a by-product.	Zhao X, Kasbi M, Chen J, Peres S, Jolicoeur M	Biotechnol Bioeng	10.1002/bit.26393	2017	Acetone/isolation & purification/metabolism, Bioreactors/microbiology, Butanols/isolation & purification/metabolism, Clostridium acetobutylicum/growth & development/metabolism, Computer Simulation, Culture Media/metabolism, Ethanol/isolation & purification/metabolism, Fermentation, Metabolic Flux Analysis/methods, Models, Biological, Riboflavin/biosynthesis/isolation & purification, Sodium Acetate/*metabolism	Enzymology
Metabolism	29050876	Comparative genomic analysis of Clostridium acetobutylicum for understanding the mutations contributing to enhanced butanol tolerance and production.	Xu M, Zhao J, Yu L, Yang ST	J Biotechnol	10.1016/j.jbiotec.2017.10.010	2017	Acetone/analysis/metabolism, Butanols/analysis/metabolism, Clostridium acetobutylicum/genetics/metabolism/physiology, DNA Mutational Analysis, Ethanol/analysis/metabolism, Fermentation, Genome, Bacterial/genetics, Genomics/*methods	Genetics
	29789978	Diauxic growth of Clostridium acetobutylicum ATCC 824 when grown on mixtures of glucose and cellobiose.	Buendia-Kandia F, Rondags E, Framboisier X, Mauviel G, Dufour A, Guedon E	AMB Express	10.1186/s13568-018-0615-2	2018
Metabolism	29987383	Improving the fermentation performance of Clostridium acetobutylicum ATCC 824 by strengthening the VB1 biosynthesis pathway.	Liao Z, Suo Y, Xue C, Fu H, Wang J	Appl Microbiol Biotechnol	10.1007/s00253-018-9208-x	2018	Butanols/metabolism, Clostridium acetobutylicum/genetics/metabolism, Culture Media, Fermentation, Genes, Bacterial, Glucose/metabolism, Metabolic Engineering, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Thiamine/*biosynthesis, Xylose/metabolism	Cultivation
Metabolism	30076425	Metabolic engineering of Clostridium acetobutylicum for the production of butyl butyrate.	Noh HJ, Woo JE, Lee SY, Jang YS	Appl Microbiol Biotechnol	10.1007/s00253-018-9267-z	2018	Acyl Coenzyme A/metabolism, Batch Cell Culture Techniques/methods, Butanols/metabolism, Butyrates/metabolism, Clostridium acetobutylicum/metabolism, Fermentation/physiology, Glucose/metabolism, Lipase/metabolism, Metabolic Engineering/methods	Biotechnology
Metabolism	30081514	Optimisation of Simultaneous Saccharification and Fermentation (SSF) for Biobutanol Production Using Pretreated Oil Palm Empty Fruit Bunch.	Md Razali NAA, Ibrahim MF, Kamal Bahrin E, Abd-Aziz S	Molecules	10.3390/molecules23081944	2018	Bioengineering, Butanols/metabolism, Cellulase/metabolism, Clostridium acetobutylicum/metabolism, Fermentation, Fruit/metabolism, Hydrogen-Ion Concentration, Hydrolysis, Palm Oil, Sugars/*metabolism	Biotechnology
	30374459	Arabinose-Induced Catabolite Repression as a Mechanism for Pentose Hierarchy Control in Clostridium acetobutylicum ATCC 824.	Servinsky MD, Renberg RL, Perisin MA, Gerlach ES, Liu S, Sund CJ	mSystems	10.1128/mSystems.00064-18	2018
Metabolism	30396113	The significance of proline on lignocellulose-derived inhibitors tolerance in Clostridium acetobutylicum ATCC 824.	Liao Z, Guo X, Hu J, Suo Y, Fu H, Wang J	Bioresour Technol	10.1016/j.biortech.2018.10.038	2018	1-Butanol/metabolism, Acetone/metabolism, Biomass, Clostridium acetobutylicum/metabolism, Drug Tolerance, Fermentation, Hydrolysis, Lignin/chemistry, Proline/metabolism, Zea mays/chemistry
Metabolism	30468318	Combining chemical flocculation and bacterial co-culture of Cupriavidus taiwanensis and Ureibacillus thermosphaericus to detoxify a hardwood hemicelluloses hydrolysate and enable acetone-butanol-ethanol fermentation leading to butanol.	Theiri M, Chadjaa H, Marinova M, Jolicoeur M	Biotechnol Prog	10.1002/btpr.2753	2018	Acetone/chemistry/metabolism, Butanols/chemistry/metabolism, Coculture Techniques, Cupriavidus/chemistry/metabolism, Ethanol/chemistry/metabolism, Fermentation, Flocculation, Hydrolysis, Planococcaceae/chemistry/metabolism, Polysaccharides/*metabolism
Metabolism	30605828	Clostridium strain selection for co-culture with Bacillus subtilis for butanol production from agave hydrolysates.	Oliva-Rodriguez AG, Quintero J, Medina-Morales MA, Morales-Martinez TK, Rodriguez-De la Garza JA, Moreno-Davila M, Aroca G, Rios Gonzalez LJ	Bioresour Technol	10.1016/j.biortech.2018.12.085	2018	Agave/metabolism, Anaerobiosis, Bacillus subtilis/metabolism, Butanols/metabolism, Clostridium acetobutylicum/metabolism, Coculture Techniques, Fermentation	Biotechnology
Metabolism	30658972	Improved n-Butanol Production from Clostridium cellulovorans by Integrated Metabolic and Evolutionary Engineering.	Wen Z, Ledesma-Amaro R, Lin J, Jiang Y, Yang S	Appl Environ Microbiol	10.1128/AEM.02560-18	2019	1-Butanol/metabolism, Bacterial Proteins/genetics/metabolism, Batch Cell Culture Techniques, Biomass, Clostridium acetobutylicum/genetics/metabolism, Clostridium cellulovorans/genetics/growth & development/metabolism, Coenzyme A/genetics, DNA, Bacterial/genetics/isolation & purification, Evolution, Molecular, Fermentation, Gene Expression Regulation, Bacterial, Lignin/metabolism, *Metabolic Engineering, Microorganisms, Genetically-Modified/genetics, Oxidoreductases/genetics	Biotechnology
Enzymology	31154278	Strategic intensification in butanol production by exogenous amino acid supplementation: Fermentation kinetics and thermodynamic studies.	Nimbalkar PR, Khedkar MA, Kulkarni RK, Chavan PV, Bankar SB	Bioresour Technol	10.1016/j.biortech.2019.121521	2019	1-Butanol, Acetone, Amino Acids, Butanols, *Clostridium acetobutylicum, Dietary Supplements, Ethanol, Fermentation, Kinetics, Thermodynamics	Biotechnology
	31183623	Kinetic modeling of Stickland reactions-coupled methanogenesis for a methanogenic culture.	Sangavai C, Bharathi M, Ganesh SP, Chellapandi P	AMB Express	10.1186/s13568-019-0803-8	2019
Metabolism	31307579	Regulation of butanol biosynthesis in Clostridium acetobutylicum ATCC 824 under the influence of zinc supplementation and magnesium starvation.	Mukherjee M, Sarkar P, Goswami G, Das D	Enzyme Microb Technol	10.1016/j.enzmictec.2019.05.009	2019	Butanols/metabolism, Clostridium acetobutylicum/metabolism, Ethanol/metabolism, Fermentation, Glucose/metabolism, Magnesium/analysis/metabolism, Zinc/analysis/metabolism
Biotechnology	31460424	Enhanced Biobutanol Production in Folic Acid-Induced Medium by Using Clostridium acetobutylicum NRRL B-527.	Nimbalkar PR, Khedkar MA, Chavan PV, Bankar SB	ACS Omega	10.1021/acsomega.9b00583	2019
	31506849	The significance of aspartate on NAD(H) biosynthesis and ABE fermentation in Clostridium acetobutylicum ATCC 824.	Liao Z, Yang X, Fu H, Wang J	AMB Express	10.1186/s13568-019-0874-6	2019
Metabolism	31807968	Biochemical characterization of an esterase from Clostridium acetobutylicum with novel GYSMG pentapeptide motif at the catalytic domain.	Nagaroor V, Gummadi SN	J Ind Microbiol Biotechnol	10.1007/s10295-019-02253-8	2019	Amino Acid Sequence, Biocatalysis, Catalytic Domain, Clostridium acetobutylicum/enzymology/genetics, Esterases/chemistry/genetics/*metabolism, Mutagenesis, Site-Directed, Peptides/chemistry/genetics/metabolism, Sequence Analysis, Protein, Temperature	Transcriptome
Biotechnology	31923698	Efficient bio-butanol production from lignocellulosic waste by elucidating the mechanisms of Clostridium acetobutylicum response to phenolic inhibitors.	Luo H, Zheng P, Bilal M, Xie F, Zeng Q, Zhu C, Yang R, Wang Z	Sci Total Environ	10.1016/j.scitotenv.2019.136399	2019	Butanols, *Clostridium acetobutylicum, Fermentation, Lignin
Metabolism	31940438	Metabolic Engineering of Clostridium cellulovorans to Improve Butanol Production by Consolidated Bioprocessing.	Wen Z, Ledesma-Amaro R, Lu M, Jin M, Yang S	ACS Synth Biol	10.1021/acssynbio.9b00331	2020	Acetyl Coenzyme A/metabolism, Acyl Coenzyme A/metabolism, Bacterial Proteins/genetics/metabolism, Batch Cell Culture Techniques, Butanols/chemistry/metabolism, Carbon/metabolism, Clostridium cellulovorans/metabolism, *Metabolic Engineering, Xylose/metabolism	Biotechnology
Metabolism	32062499	Butyric acid production from spent coffee grounds by engineered Clostridium tyrobutyricum overexpressing galactose catabolism genes.	He F, Qin S, Yang Z, Bai X, Suo Y, Wang J	Bioresour Technol	10.1016/j.biortech.2020.122977	2020	Butyric Acid, Clostridium acetobutylicum, Clostridium tyrobutyricum, Coffee, Fermentation, Galactose	Biotechnology
Metabolism	32170874	Combined evolutionary engineering and genetic manipulation improve low pH tolerance and butanol production in a synthetic microbial Clostridium community.	Wen Z, Ledesma-Amaro R, Lu M, Jiang Y, Gao S, Jin M, Yang S	Biotechnol Bioeng	10.1002/bit.27333	2020	Butanols/metabolism, Clostridium/genetics/metabolism, Clostridium acetobutylicum/genetics/metabolism, Clostridium beijerinckii/genetics/metabolism, Genetic Engineering/*methods, Hydrogen-Ion Concentration, Metabolic Engineering/methods, Microbiota	Biotechnology
Metabolism	32375981	RRNPP-type quorum sensing affects solvent formation and sporulation in Clostridium acetobutylicum.	Kotte AK, Severn O, Bean Z, Schwarz K, Minton NP, Winzer K	Microbiology (Reading)	10.1099/mic.0.000916	2020	Bacterial Proteins/genetics/metabolism, Base Composition, Base Sequence, Clostridium acetobutylicum/genetics/growth & development/physiology, Gene Expression Regulation, Bacterial, Multigene Family, Quorum Sensing, Sequence Analysis, DNA, Spores, Bacterial/genetics/growth & development/metabolism	Transcriptome
Enzymology	32385078	A CRISPR/Anti-CRISPR Genome Editing Approach Underlines the Synergy of Butanol Dehydrogenases in Clostridium acetobutylicum DSM 792.	Wasels F, Chartier G, Hocq R, Lopes Ferreira N	Appl Environ Microbiol	10.1128/AEM.00408-20	2020	Alcohol Oxidoreductases/genetics/metabolism, Bacterial Proteins/genetics/metabolism, CRISPR-Cas Systems/genetics, Clostridium acetobutylicum/enzymology/genetics, Gene Editing	Metabolism
Metabolism	32851482	Genetic sensor-regulators functional in Clostridia.	Han S, Kim Y, Karanjikar M, San KY, Bennett GN	J Ind Microbiol Biotechnol	10.1007/s10295-020-02303-6	2020	Clostridium acetobutylicum/enzymology/genetics/metabolism, Clostridium beijerinckii/genetics/metabolism, Fermentation, Genes, Regulator, Genes, Reporter, Glucose/metabolism, Plasmids, Promoter Regions, Genetic, Transformation, Bacterial, Xylose/metabolism, beta-Galactosidase/*genetics/metabolism	Enzymology
	33042064	Transcriptomic and Phenotypic Analysis of a spoIIE Mutant in Clostridium beijerinckii.	Diallo M, Kint N, Monot M, Collas F, Martin-Verstraete I, van der Oost J, Kengen SWM, Lopez-Contreras AM	Front Microbiol	10.3389/fmicb.2020.556064	2020
Biotechnology	33391222	Effects of Carbon Ion Beam Irradiation on Butanol Tolerance and Production of Clostridium acetobutylicum.	Gao Y, Zhang M, Zhou X, Guo X, Lei C, Li W, Lu D	Front Microbiol	10.3389/fmicb.2020.602774	2020
	33420096	Co-feeding glucose with either gluconate or galacturonate during clostridial fermentations provides metabolic fine-tuning capabilities.	Zu TNK, Liu S, Gerlach ES, Mojadedi W, Sund CJ	Sci Rep	10.1038/s41598-020-76761-4	2021
Stress	33606076	Response characteristics of the membrane integrity and physiological activities of the mutant strain Y217 under exogenous butanol stress.	Gao Y, Zhou X, Zhang MM, Liu YJ, Guo XP, Lei CR, Li WJ, Lu D	Appl Microbiol Biotechnol	10.1007/s00253-021-11174-5	2021	1-Butanol, Butanols/toxicity, Clostridium acetobutylicum, Membrane Proteins
Biotechnology	34624476	Saccharification of lignocellulosic biomass using an enzymatic cocktail of fungal origin and successive production of butanol by Clostridium acetobutylicum.	Mondal S, Santra S, Rakshit S, Kumar Halder S, Hossain M, Chandra Mondal K	Bioresour Technol	10.1016/j.biortech.2021.126093	2021	Biomass, Butanols, *Clostridium acetobutylicum, Fermentation, Hydrolysis, Lignin, Polyporaceae, Trametes
	34760879	Clostridium acetobutylicum atpG-Knockdown Mutants Increase Extracellular pH in Batch Cultures.	Jang YS, Seong HJ, Kwon SW, Lee YS, Im JA, Lee HL, Yoon YR, Lee SY	Front Bioeng Biotechnol	10.3389/fbioe.2021.754250	2021
Biotechnology	35395367	Biodeinking of waste papers using combinatorial fungal enzymes and subsequent production of butanol from effluent.	Mondal S, Biswal D, Pal K, Rakshit S, Kumar Halder S, Mandavgane SA, Bera D, Hossain M, Chandra Mondal K	Bioresour Technol	10.1016/j.biortech.2022.127078	2022	1-Butanol, Butanols, Cellulase, Clostridium acetobutylicum, Ink, Paper	Enzymology
Metabolism	35412381	Genome-Wide TSS Distribution in Three Related Clostridia with Normalized Capp-Switch Sequencing.	Hocq R, Jagtap S, Boutard M, Tolonen AC, Duval L, Pirayre A, Lopes Ferreira N, Wasels F	Microbiol Spectr	10.1128/spectrum.02288-21	2022	Acetone/metabolism, Bacteria, Anaerobic, Butanols/metabolism, Clostridium/genetics/metabolism, Clostridium acetobutylicum/genetics/metabolism, Fermentation
Biotechnology	35518483	Co-production of solvents and organic acids in butanol fermentation by Clostridium acetobutylicum in the presence of lignin-derived phenolics.	Luo H, Zheng P, Xie F, Yang R, Liu L, Han S, Zhao Y, Bilal M	RSC Adv	10.1039/c9ra00325h	2019

Reference

@id	authors	catalogue	doi/url	title	journal	pubmed
449	Curators of the DSMZ	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 792)	https://www.dsmz.de/collection/catalogue/details/culture/DSM-792
20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.		10.1099/ijsem.0.004332	List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.		10.1016/j.syapm.2013.11.002	StrainInfo introduces electronic passports for microorganisms.	Syst Appl Microbiol. 37: 42-50 2014	24321274
55354	Curators of the CCUG	Culture Collection University of Gothenburg (CCUG) (CCUG 42182 C)	https://www.ccug.se/strain?id=42182
66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann		https://diaspora-project.de/progress.html#genomes	Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg		10.1093/nar/gkaa1025	BRENDA, the ELIXIR core data resource in 2021: new developments and updates	Nucleic Acids Res. 49: D498-D508 2020	33211880
67770	Curators of the JCM		https://jcm.brc.riken.jp/en/
68380				Automatically annotated from API rID32A
68382				Automatically annotated from API zym
69480	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann		https://diaspora-project.de/progress.html#genomes	Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
69481	Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch		10.21203/rs.3.rs-2527258/v1	Predictions based on the model GenomeNet Sporulation v. 1
72063	Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.		10.60712/SI-ID92208.1	StrainInfo: A central database for resolving microbial strain identifiers