Strain identifier
BacDive ID: 2393
Type strain: 
Species: Chlamydia trachomatis
Strain Designation: UW-3/Cx
Strain history: <- S. Gronow, Leibniz-Institut DSMZ GmbH, Braunschweig, Germany; <- H. Brade; <- ATCC; ATCC VR-885 <- S.-P. Wang; UW-3/Cx
NCBI tax ID(s): 813 (species)
version 8.1 (current version)
General
@ref: 8092
BacDive-ID: 2393
DSM-Number: 19411
keywords: 16S sequence, Bacteria, mesophilic
description: Chlamydia trachomatis UW-3/Cx is a mesophilic bacterium that was isolated from human cervix, asymptomatic.
NCBI tax id
- NCBI tax id: 813
- Matching level: species
strain history
- @ref: 8092
- history: <- S. Gronow, Leibniz-Institut DSMZ GmbH, Braunschweig, Germany; <- H. Brade; <- ATCC; ATCC VR-885 <- S.-P. Wang; UW-3/Cx
doi: 10.13145/bacdive2393.20230509.8.1
Name and taxonomic classification
LPSN
- @ref: 20215
- description: domain/bacteria
- keyword: phylum/chlamydiota
- domain: Bacteria
- phylum: Chlamydiota
- class: Chlamydiia
- order: Chlamydiales
- family: Chlamydiaceae
- genus: Chlamydia
- species: Chlamydia trachomatis
- full scientific name: Chlamydia trachomatis (Busacca 1935) Rake 1957 (Approved Lists 1980)
synonyms
- @ref: 20215
- synonym: Rickettsia trachomae
@ref: 8092
domain: Bacteria
phylum: Chlamydiae
class: Chlamydiia
order: Chlamydiales
family: Chlamydiaceae
genus: Chlamydia
species: Chlamydia trachomatis
full scientific name: Chlamydia trachomatis (Busacca 1935) Rake 1957 emend. Everett et al. 1999
strain designation: UW-3/Cx
type strain: no
Morphology
colony morphology
- @ref: 8092
- incubation period: 3-7 days
Culture and growth conditions
culture medium
- @ref: 8092
- name: CULTIVATION MEDIUM FOR CHLAMYDIAE (DSMZ Medium 1193)
- growth: yes
- link: https://mediadive.dsmz.de/medium/1193
- composition: Name: CULTIVATION MEDIUM FOR CHLAMYDIAE (DSMZ Medium 1193) Composition: Aminoacids Fetal bovine serum IMDM-Medium
culture temp
- @ref: 8092
- growth: positive
- type: growth
- temperature: 37
- range: mesophilic
Isolation, sampling and environmental information
isolation
- @ref: 8092
- sample type: human cervix, asymptomatic
- country: USA
- origin.country: USA
- continent: North America
isolation source categories
- Cat1: #Host
- Cat2: #Human
taxonmaps
- @ref: 69479
- File name: preview.99_182.png
- url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_62;96_131;97_141;98_158;99_182&stattab=map
- Last taxonomy: Chlamydia trachomatis
- 16S sequence: CP002054
- Sequence Identity:
- Total samples: 4780
- soil counts: 233
- aquatic counts: 198
- animal counts: 4312
- plant counts: 37
Safety information
risk assessment
- @ref: 8092
- biosafety level: 2
- biosafety level comment: Risk group (German classification)
Sequence information
16S sequences
- @ref: 8092
- description: Chlamydia trachomatis D-LC, complete genome
- accession: CP002054
- length: 1042520
- database: ena
- NCBI tax ID: 759364
External links
@ref: 8092
culture collection no.: DSM 19411, ATCC VR-885
straininfo link
- @ref: 71948
- straininfo: 408097
literature
| topic | Pubmed-ID | title | authors | journal | DOI | year | mesh | topic2 |
|---|---|---|---|---|---|---|---|---|
| Pathogenicity | 1317145 | In vitro and in vivo activities of sparfloxacin, other quinolones, and tetracyclines against Chlamydia trachomatis. | Nakata K, Maeda H, Fujii A, Arakawa S, Umezu K, Kamidono S | Antimicrob Agents Chemother | 10.1128/AAC.36.1.188 | 1992 | Administration, Oral, Animals, Anti-Infective Agents/*therapeutic use, Chlamydia Infections/drug therapy, Chlamydia trachomatis/*drug effects, *Fluoroquinolones, Mice, Microbial Sensitivity Tests, Quinolones/*therapeutic use, Tetracyclines/*therapeutic use | |
| Pathogenicity | 1537913 | Detection of Chlamydia pneumoniae by polymerase chain reaction. | Campbell LA, Perez Melgosa M, Hamilton DJ, Kuo CC, Grayston JT | J Clin Microbiol | 10.1128/jcm.30.2.434-439.1992 | 1992 | Base Sequence, Chlamydia Infections/diagnosis/microbiology, Chlamydophila pneumoniae/*genetics/isolation & purification, DNA Probes, DNA, Bacterial/genetics, Evaluation Studies as Topic, Humans, Molecular Sequence Data, Polymerase Chain Reaction/*methods | Genetics |
| Pathogenicity | 9659244 | The inhibitory effect of phosphate on the ligase chain reaction used for detecting Chlamydia trachomatis. | Notomi T, Ikeda Y, Okadome A, Nagayama A | J Clin Pathol | 10.1136/jcp.51.4.306 | 1998 | Chlamydia Infections/*diagnosis, Chlamydia trachomatis/genetics/*isolation & purification, Clinical Enzyme Tests/*methods, False Negative Reactions, Gene Amplification/drug effects, Humans, *Ligases, Nucleic Acid Amplification Techniques, Phosphates/*pharmacology, Reagent Kits, Diagnostic, Sensitivity and Specificity | Enzymology |
| Pathogenicity | 11810568 | Detection of antimicrobial-treated Chlamydia trachomatis with Amplicor PCR test kit. | Takahashi S, Hagiwara T, Shiga S, Hirose T, Tsukamoto T | J Infect Chemother | 10.1007/s101560070005 | 2000 | Anti-Bacterial Agents/pharmacology, Chlamydia Infections/*diagnosis, Chlamydia trachomatis/classification/drug effects/genetics/*isolation & purification/ultrastructure, DNA Primers, DNA, Bacterial/*genetics, Humans, Microbial Sensitivity Tests, Polymerase Chain Reaction/*standards, Predictive Value of Tests, Reagent Kits, Diagnostic | Phylogeny |
| Pathogenicity | 14583635 | In vitro inhibitory effects of tea polyphenols on the proliferation of Chlamydia trachomatis and Chlamydia pneumoniae. | Yamazaki T, Inoue M, Sasaki N, Hagiwara T, Kishimoto T, Shiga S, Ogawa M, Hara Y, Matsumoto T | Jpn J Infect Dis | 2003 | Chlamydia trachomatis/*drug effects/growth & development, Chlamydophila pneumoniae/*drug effects/growth & development, Dose-Response Relationship, Drug, Flavonoids/*pharmacology, Microbial Sensitivity Tests, Phenols/*pharmacology, Polyphenols, *Tea | ||
| Pathogenicity | 15059212 | Inactivation of Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae by ozone. | Yamazaki T, Inoue M, Ogawa M, Shiga S, Kishimoto T, Hagiwara T, Matsumoto T, Hayashi T | Lett Appl Microbiol | 10.1111/j.1472-765X.2004.01506.x | 2004 | Cell Line, Chlamydia trachomatis/*drug effects/*growth & development, Chlamydophila pneumoniae/*drug effects/*growth & development, Disinfection/*methods, HeLa Cells/microbiology, Humans, Ozone/*pharmacology | |
| Pathogenicity | 15728882 | Emergence of resistance to rifampin and rifalazil in Chlamydophila pneumoniae and Chlamydia trachomatis. | Kutlin A, Kohlhoff S, Roblin P, Hammerschlag MR, Riska P | Antimicrob Agents Chemother | 10.1128/AAC.49.3.903-907.2005 | 2005 | Base Sequence, Chlamydia trachomatis/*drug effects/genetics, Chlamydophila pneumoniae/*drug effects/genetics, DNA-Directed RNA Polymerases/genetics, Drug Resistance, Bacterial, Microbial Sensitivity Tests, Molecular Sequence Data, Mutation, Rifampin/*pharmacology, Rifamycins/*pharmacology | Genetics |
| Pathogenicity | 15917555 | Biosynthesized tea polyphenols inactivate Chlamydia trachomatis in vitro. | Yamazaki T, Kishimoto T, Shiga S, Sato K, Hagiwara T, Inoue M, Sasaki N, Ouchi K, Hara Y | Antimicrob Agents Chemother | 10.1128/AAC.49.6.2501-2503.2005 | 2005 | Anti-Bacterial Agents/biosynthesis/chemistry/*pharmacology, Catechin/*analogs & derivatives/biosynthesis/chemistry/pharmacology, Chlamydia trachomatis/*drug effects/growth & development, Flavonoids/*biosynthesis/chemistry/*pharmacology, HeLa Cells/microbiology, Humans, Microbial Sensitivity Tests/methods, Phenols/chemistry/*pharmacology, Polyphenols, Tea/*chemistry | |
| Pathogenicity | 15917561 | In vitro inhibitory effects of hinokitiol on proliferation of Chlamydia trachomatis. | Yamano H, Yamazaki T, Sato K, Shiga S, Hagiwara T, Ouchi K, Kishimoto T | Antimicrob Agents Chemother | 10.1128/AAC.49.6.2519-2521.2005 | 2005 | Anti-Infective Agents/*pharmacology/toxicity, Chlamydia trachomatis/*drug effects/*growth & development, Dose-Response Relationship, Drug, HeLa Cells/drug effects/microbiology, Humans, Microbial Sensitivity Tests/methods, Monoterpenes/*pharmacology/toxicity, Tropolone/*analogs & derivatives/*pharmacology/toxicity | |
| Pathogenicity | 18524545 | Potential of a novel polyherbal formulation BASANT for prevention of Chlamydia trachomatis infection. | Bhengraj AR, Dar SA, Talwar GP, Mittal A | Int J Antimicrob Agents | 10.1016/j.ijantimicag.2008.02.010 | 2008 | Anti-Bacterial Agents/*pharmacology, Chlamydia trachomatis/*drug effects, Colony Count, Microbial, Epithelial Cells/microbiology, Female, HeLa Cells, Humans, Microbial Sensitivity Tests, Plant Extracts/*pharmacology, Plants, Medicinal, Time Factors | |
| Metabolism | 21199910 | Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum. | O'Connell CM, AbdelRahman YM, Green E, Darville HK, Saira K, Smith B, Darville T, Scurlock AM, Meyer CR, Belland RJ | Infect Immun | 10.1128/IAI.01118-10 | 2011 | Animals, Cell Line, Chlamydia Infections/*genetics/metabolism, Chlamydia muridarum/*genetics/metabolism/pathogenicity, Chlamydia trachomatis/*genetics/metabolism/pathogenicity, Chromosomes, Bacterial/genetics, Gene Expression, Gene Expression Regulation, Bacterial/*genetics, Genetic Loci, Glucose/metabolism, Glycogen/metabolism, Glycogen Synthase/biosynthesis/genetics, Humans, Inclusion Bodies/metabolism, Mice, Oligonucleotide Array Sequence Analysis, Plasmids/*genetics, Reverse Transcriptase Polymerase Chain Reaction, Toll-Like Receptor 2/*metabolism, Virulence/genetics | Pathogenicity |
| 21825059 | Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection. | Frazer LC, O'Connell CM, Andrews CW Jr, Zurenski MA, Darville T | Infect Immun | 10.1128/IAI.05535-11 | 2011 | Animals, Chlamydia Infections/immunology/*pathology, Chlamydia muridarum/*pathogenicity, Female, Genital Diseases, Female/immunology/*pathology, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Neutrophil Infiltration/*immunology, Neutrophils/immunology/*pathology, Oviducts/immunology/*pathology, Severity of Illness Index | ||
| Metabolism | 22113367 | In vitro antichlamydial activity of garenoxacin against Chlamydia trachomatis. | Futakuchi N, Nakatani M, Takahata M, Mitsuyama J | J Infect Chemother | 10.1007/s10156-011-0345-8 | 2011 | Anti-Bacterial Agents/pharmacokinetics/*pharmacology, Bacterial Proteins/genetics/metabolism, Chlamydia trachomatis/*drug effects/genetics/metabolism, DNA Gyrase/genetics/metabolism, Enzyme Assays, Fluoroquinolones/pharmacokinetics/*pharmacology, HeLa Cells, Humans, Microbial Sensitivity Tests, Microscopy, Electron, Transmission, Recombinant Proteins/genetics/metabolism | Pathogenicity |
| Phylogeny | 23287699 | Differences in infectivity and induction of infertility: a comparative study of Chlamydia trachomatis strains in the murine model. | Carmichael JR, Tifrea D, Pal S, de la Maza LM | Microbes Infect | 10.1016/j.micinf.2012.12.001 | 2012 | Animals, Chlamydia Infections/immunology/*microbiology, Chlamydia trachomatis/classification/genetics/*pathogenicity, Disease Models, Animal, Female, Fertility, Infertility/*microbiology, Male, Medroxyprogesterone Acetate/pharmacology, Mice, Mice, Inbred C3H, Statistics, Nonparametric, Vagina/microbiology | |
| Enzymology | 23478318 | Vaccination with the recombinant major outer membrane protein elicits antibodies to the constant domains and induces cross-serovar protection against intranasal challenge with Chlamydia trachomatis. | Tifrea DF, Ralli-Jain P, Pal S, de la Maza LM | Infect Immun | 10.1128/IAI.00734-12 | 2013 | Adjuvants, Immunologic/administration & dosage/pharmacology, Administration, Intranasal, Animals, Antibodies, Bacterial/blood, Bacterial Outer Membrane Proteins/administration & dosage/*immunology, Bacterial Vaccines/administration & dosage/*immunology, Body Weight/immunology, Chlamydia Infections/immunology/*prevention & control, Chlamydia muridarum/isolation & purification, Chlamydia trachomatis/*immunology, Colony Count, Microbial, Female, Immunity, Humoral/physiology, Lung/microbiology, Mice, Mice, Inbred BALB C, Recombinant Proteins/immunology, T-Lymphocytes/immunology, Vaccination/methods | Phylogeny |
| Phylogeny | 26216426 | Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D. | Qu Y, Frazer LC, O'Connell CM, Tarantal AF, Andrews CW Jr, O'Connor SL, Russell AN, Sullivan JE, Poston TB, Vallejo AN, Darville T | Infect Immun | 10.1128/IAI.00841-15 | 2015 | Animals, CD8-Positive T-Lymphocytes/immunology, Chlamydia Infections/immunology/*microbiology/pathology, Chlamydia trachomatis/classification/genetics/isolation & purification/*physiology, Female, Humans, Macaca mulatta, Plasmids/genetics/metabolism, Reproductive Tract Infections/immunology/*microbiology/pathology, Serogroup | Pathogenicity |
| Pathogenicity | 27993657 | Genome analysis of Chlamydia trachomatis for functional characterization of hypothetical proteins to discover novel drug targets. | Turab Naqvi AA, Rahman S, Rubi, Zeya F, Kumar K, Choudhary H, Jamal MS, Kim J, Hassan MI | Int J Biol Macromol | 10.1016/j.ijbiomac.2016.12.045 | 2016 | Bacterial Proteins/*genetics/*metabolism, Chlamydia trachomatis/*drug effects/*genetics/metabolism, *Genomics, Molecular Targeted Therapy | Metabolism |
| Pathogenicity | 29038126 | Transcervical Inoculation with Chlamydia trachomatis Induces Infertility in HLA-DR4 Transgenic and Wild-Type Mice. | Pal S, Tifrea DF, Zhong G, de la Maza LM | Infect Immun | 10.1128/IAI.00722-17 | 2017 | Administration, Intranasal/methods, Animals, Antibodies, Bacterial/immunology, Bacterial Vaccines/immunology, Cell Line, Tumor, Chlamydia Infections/*immunology/microbiology, Chlamydia trachomatis/*immunology, Disease Models, Animal, Female, HLA-DR4 Antigen/*immunology, HeLa Cells, Humans, Immunity, Cellular/immunology, Immunity, Humoral/immunology, Infertility/*immunology/*microbiology, Mice, Mice, Inbred C57BL, Mice, Transgenic/*immunology/microbiology, Vaccination/methods, Vagina/immunology/microbiology | |
| Enzymology | 31504647 | A Recombinant Chlamydia trachomatis MOMP Vaccine Elicits Cross-serogroup Protection in Mice Against Vaginal Shedding and Infertility. | Tifrea DF, Pal S, de la Maza LM | J Infect Dis | 10.1093/infdis/jiz438 | 2020 | Animals, Bacterial Vaccines/immunology/therapeutic use, Chlamydia Infections/immunology/microbiology/*prevention & control, Chlamydia trachomatis/immunology/isolation & purification, Cross Protection/*immunology, Female, Immunoglobulin G, Infertility, Female/microbiology/*prevention & control, Male, Mice, Mice, Inbred C3H, Porins/*immunology, Pregnancy, Serogroup, Vaccines, Synthetic/*immunology, Vagina/immunology/*microbiology | Phylogeny |
| Phenotype | 34151159 | Chlamydial clinical isolates show subtle differences in persistence phenotypes and growth in vitro. | Thomas M, Lawrence A, Kroon S, Vodstrcil LA, Phillips S, Hocking JS, Timms P, Huston WM | Access Microbiol | 10.1099/acmi.0.000204 | 2021 | ||
| Metabolism | 34662351 | Human genital antibody-mediated inhibition of Chlamydia trachomatis infection and evidence for ompA genotype-specific neutralization. | Ardizzone CM, Albritton HL, Lillis RA, Bagnetto CEL, Shen L, Cavacini LA, Kozlowski PA, Quayle AJ | PLoS One | 10.1371/journal.pone.0258759 | 2021 | Adult, Antibodies, Bacterial/blood/metabolism, Antibodies, Neutralizing/blood/*metabolism, Bacterial Outer Membrane Proteins/*genetics/immunology, Cell Line, Cervix Uteri/cytology/*immunology/virology, Chlamydia Infections/*immunology, Chlamydia trachomatis/genetics/*immunology, Epithelial Cells/cytology/immunology/virology, Female, Genotype, Humans, Immunoglobulin A/blood/metabolism, Immunoglobulin G/blood/metabolism, Phylogeny, Sequence Analysis, DNA, Young Adult | Genetics |
| Metabolism | 35234139 | Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx. | Maddy J, Staker BL, Subramanian S, Abendroth J, Edwards TE, Myler PJ, Hybiske K, Asojo OA | Acta Crystallogr F Struct Biol Commun | 10.1107/S2053230X22002138 | 2022 | *Chlamydia trachomatis/metabolism, Crystallography, X-Ray, *Inorganic Pyrophosphatase/metabolism, United States |
Reference
| @id | authors | catalogue | doi/url | title |
|---|---|---|---|---|
| 8092 | Curators of the DSMZ | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 19411) | https://www.dsmz.de/collection/catalogue/details/culture/DSM-19411 | |
| 20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M. | 10.1099/ijsem.0.004332 | List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ | |
| 69479 | João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich. | https://microbeatlas.org/ | MicrobeAtlas 1.0 beta | |
| 71948 | Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J. | 10.60712/SI-ID408097.1 | StrainInfo: A central database for resolving microbial strain identifiers |