Strain identifier
BacDive ID: 16214
Type strain: 
Species: Streptomyces avermitilis
Strain Designation: MA-4680
Strain history: CIP <- 2012, DSMZ <- IMET <- JCM "Streptomyces avermectinius"
NCBI tax ID(s): 227882 (strain), 33903 (species)
version 8.1 (current version)
General
@ref: 12580
BacDive-ID: 16214
DSM-Number: 46492
keywords: genome sequence, 16S sequence, Bacteria, obligate aerobe, spore-forming, mesophilic, Gram-positive
description: Streptomyces avermitilis MA-4680 is an obligate aerobe, spore-forming, mesophilic bacterium that builds an aerial mycelium and was isolated from soil.
NCBI tax id
| NCBI tax id | Matching level |
|---|---|
| 33903 | species |
| 227882 | strain |
strain history
| @ref | history |
|---|---|
| 12580 | <- IMET <- JCM (Streptomyces avermitilis) |
| 67770 | KCC S-1070 <-- NRRL 8165 <-- Merck Sharp & Dohme Res. Labs.; MA-4680. |
| 116661 | CIP <- 2012, DSMZ <- IMET <- JCM "Streptomyces avermectinius" |
doi: 10.13145/bacdive16214.20230509.8.1
Name and taxonomic classification
LPSN
- @ref: 20215
- description: domain/bacteria
- keyword: phylum/actinomycetota
- domain: Bacteria
- phylum: Actinomycetota
- class: Actinomycetes
- order: Kitasatosporales
- family: Streptomycetaceae
- genus: Streptomyces
- species: Streptomyces avermitilis
- full scientific name: Streptomyces avermitilis (ex Burg et al. 1979) Kim and Goodfellow 2002
synonyms
- @ref: 20215
- synonym: Streptomyces avermectinius
@ref: 12580
domain: Bacteria
phylum: Actinobacteria
class: Actinobacteria
order: Actinomycetales
family: Streptomycetaceae
genus: Streptomyces
species: Streptomyces avermitilis
full scientific name: Streptomyces avermitilis (ex Burg et al. 1979) Kim and Goodfellow 2002
strain designation: MA-4680
type strain: yes
Morphology
cell morphology
| @ref | gram stain | confidence | cell shape | motility |
|---|---|---|---|---|
| 69480 | positive | 100 | ||
| 116661 | positive | rod-shaped | no |
colony morphology
| @ref | colony color | incubation period | medium used |
|---|---|---|---|
| 20195 | Ochre brown (8001) | 10-14 days | ISP 2 |
| 20195 | Ochre brown (8001) | 10-14 days | ISP 3 |
| 20195 | Ochre brown (8001) | 10-14 days | ISP 4 |
| 20195 | Ochre brown (8001) | 10-14 days | ISP 5 |
| 20195 | Ochre brown (8001) | 10-14 days | ISP 6 |
| 20195 | Ochre brown (8001) | 10-14 days | ISP 7 |
| 116661 |
multicellular morphology
| @ref | forms multicellular complex | complex name | complex color | medium name |
|---|---|---|---|---|
| 20195 | yes | Aerial Mycelium | Green grey | ISP 2 |
| 20195 | yes | Aerial Mycelium | Green grey | ISP 3 |
| 20195 | yes | Aerial Mycelium | Green grey | ISP 4 |
| 20195 | yes | Aerial Mycelium | Green grey | ISP 5 |
| 20195 | no | ISP 6 | ||
| 20195 | yes | Aerial Mycelium | Green grey | ISP 7 |
multimedia
| @ref | multimedia content | intellectual property rights | caption |
|---|---|---|---|
| 12580 | https://www.dsmz.de/microorganisms/photos/DSM_46492-1.jpg | © Leibniz-Institut DSMZ | |
| 12580 | https://www.dsmz.de/microorganisms/photos/DSM_46492.jpg | © Leibniz-Institut DSMZ | Medium 65 28°C |
Culture and growth conditions
culture medium
| @ref | name | growth | link | composition |
|---|---|---|---|---|
| 12580 | ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) | yes | https://mediadive.dsmz.de/medium/84 | Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water |
| 12580 | GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) | yes | https://mediadive.dsmz.de/medium/65 | Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water |
| 20195 | ISP 2 | yes | Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes | |
| 20195 | ISP 3 | yes | Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms: | |
| 20195 | ISP 4 | yes | Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml | |
| 20195 | ISP 5 | yes | Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes | |
| 20195 | ISP 6 | yes | Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes | |
| 20195 | ISP 7 | yes | Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes | |
| 36514 | MEDIUM 275 - for Actinomadura rugatobispora and Actinomadura verrucosospora | yes | Distilled water make up to (1000.000 ml);Sodium chloride (1.000 g);Magnesium sulphate heptahydrate (1.000 g);Agar (20.000 g);Ammonium sulphate (2.000 g);Starch maize (10.000 g);Calcium carbonate (2.000 g);Trace salt solution - M00447 (1.000 ml) | |
| 116661 | CIP Medium 72 | yes | https://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=72 | |
| 116661 | CIP Medium 275 | yes | https://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=275 |
culture temp
| @ref | growth | type | temperature | range |
|---|---|---|---|---|
| 12580 | positive | growth | 28 | mesophilic |
| 20195 | positive | optimum | 28 | mesophilic |
| 36514 | positive | growth | 30 | mesophilic |
| 67770 | positive | growth | 28 | mesophilic |
| 116661 | positive | growth | 25-37 | mesophilic |
| 116661 | no | growth | 10 | psychrophilic |
| 116661 | no | growth | 41 | thermophilic |
| 116661 | no | growth | 45 | thermophilic |
Physiology and metabolism
oxygen tolerance
- @ref: 116661
- oxygen tolerance: obligate aerobe
spore formation
| @ref | spore formation | confidence |
|---|---|---|
| 69481 | yes | 100 |
| 69480 | yes | 100 |
compound production
| @ref | compound |
|---|---|
| 12580 | C-076 and derivatives |
| 12580 | avermectins |
| 20195 | Avermectins |
halophily
| @ref | salt | growth | tested relation | concentration |
|---|---|---|---|---|
| 20195 | NaCl | positive | maximum | 5 % |
| 116661 | NaCl | positive | growth | 0-2 % |
| 116661 | NaCl | no | growth | 4 % |
| 116661 | NaCl | no | growth | 6 % |
| 116661 | NaCl | no | growth | 8 % |
| 116661 | NaCl | no | growth | 10 % |
observation
- @ref: 67770
- observation: quinones: MK-9(H6), MK-9(H6), MK-9(H8)
metabolite utilization
| @ref | Chebi-ID | metabolite | utilization activity | kind of utilization tested |
|---|---|---|---|---|
| 20195 | 17234 | glucose | + | |
| 20195 | 22599 | arabinose | + | |
| 20195 | 17992 | sucrose | - | |
| 20195 | 18222 | xylose | - | |
| 20195 | 17268 | myo-inositol | +/- | |
| 20195 | 29864 | mannitol | + | |
| 20195 | 28757 | fructose | + | |
| 20195 | 26546 | rhamnose | + | |
| 20195 | 16634 | raffinose | +/- | |
| 20195 | 62968 | cellulose | - | |
| 68368 | 5291 | gelatin | + | hydrolysis |
| 68368 | 27897 | tryptophan | + | energy source |
| 68368 | 16199 | urea | - | hydrolysis |
| 68368 | 16947 | citrate | + | assimilation |
| 68368 | 18257 | ornithine | - | degradation |
| 68368 | 25094 | lysine | - | degradation |
| 68368 | 29016 | arginine | - | hydrolysis |
| 116661 | 16947 | citrate | - | carbon source |
| 116661 | 4853 | esculin | + | hydrolysis |
| 116661 | 17632 | nitrate | + | reduction |
| 116661 | 16301 | nitrite | - | reduction |
| 116661 | 17632 | nitrate | - | respiration |
metabolite production
| @ref | Chebi-ID | metabolite | production |
|---|---|---|---|
| 67770 | 50344 | avermectin | yes |
| 68368 | 15688 | acetoin | yes |
| 68368 | 35581 | indole | yes |
| 68368 | 16136 | hydrogen sulfide | no |
| 116661 | 35581 | indole | no |
metabolite tests
| @ref | Chebi-ID | metabolite | voges-proskauer-test | indole test | methylred-test |
|---|---|---|---|---|---|
| 68368 | 15688 | acetoin | + | ||
| 68368 | 35581 | indole | + | ||
| 116661 | 15688 | acetoin | - | ||
| 116661 | 17234 | glucose | - |
enzymes
| @ref | value | activity | ec |
|---|---|---|---|
| 68368 | gelatinase | + | |
| 68368 | tryptophan deaminase | - | 4.1.99.1 |
| 68368 | urease | - | 3.5.1.5 |
| 68368 | ornithine decarboxylase | - | 4.1.1.17 |
| 68368 | lysine decarboxylase | - | 4.1.1.18 |
| 68368 | arginine dihydrolase | - | 3.5.3.6 |
| 68368 | beta-galactosidase | - | 3.2.1.23 |
| 116661 | oxidase | - | |
| 116661 | beta-galactosidase | - | 3.2.1.23 |
| 116661 | alcohol dehydrogenase | - | 1.1.1.1 |
| 116661 | gelatinase | + | |
| 116661 | amylase | + | |
| 116661 | DNase | - | |
| 116661 | caseinase | - | 3.4.21.50 |
| 116661 | catalase | + | 1.11.1.6 |
| 116661 | tween esterase | - | |
| 116661 | gamma-glutamyltransferase | - | 2.3.2.2 |
| 116661 | lecithinase | - | |
| 116661 | lipase | - | |
| 116661 | lysine decarboxylase | - | 4.1.1.18 |
| 116661 | ornithine decarboxylase | - | 4.1.1.17 |
| 116661 | protease | - | |
| 116661 | tryptophan deaminase | - | |
| 116661 | urease | - | 3.5.1.5 |
| 68382 | alkaline phosphatase | + | 3.1.3.1 |
| 68382 | esterase (C 4) | + | |
| 68382 | esterase lipase (C 8) | + | |
| 68382 | lipase (C 14) | - | |
| 68382 | leucine arylamidase | + | 3.4.11.1 |
| 68382 | valine arylamidase | + | |
| 68382 | cystine arylamidase | + | 3.4.11.3 |
| 68382 | trypsin | - | 3.4.21.4 |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 |
| 68382 | acid phosphatase | + | 3.1.3.2 |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | |
| 68382 | alpha-galactosidase | - | 3.2.1.22 |
| 68382 | beta-galactosidase | - | 3.2.1.23 |
| 68382 | beta-glucuronidase | - | 3.2.1.31 |
| 68382 | alpha-glucosidase | - | 3.2.1.20 |
| 68382 | beta-glucosidase | + | 3.2.1.21 |
| 68382 | N-acetyl-beta-glucosaminidase | + | 3.2.1.52 |
| 68382 | alpha-mannosidase | - | 3.2.1.24 |
| 68382 | alpha-fucosidase | - | 3.2.1.51 |
API zym
| @ref | Control | Alkaline phosphatase | Esterase | Esterase Lipase | Lipase | Leucine arylamidase | Valine arylamidase | Cystine arylamidase | Trypsin | alpha- Chymotrypsin | Acid phosphatase | Naphthol-AS-BI-phosphohydrolase | alpha- Galactosidase | beta- Galactosidase | beta- Glucuronidase | alpha- Glucosidase | beta- Glucosidase | N-acetyl-beta- glucosaminidase | alpha- Mannosidase | alpha- Fucosidase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 116661 | - | + | + | + | - | + | + | + | - | - | + | + | - | - | - | - | + | + | - | - |
API 20E
| @ref | ONPG | ADH Arg | LDC Lys | ODC | CIT | H2S | URE | TDA Trp | IND | VP | GEL |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 20195 | - | - | - | - | + | - | - | - | + | + | + |
Isolation, sampling and environmental information
isolation
| @ref | sample type | geographic location | country | origin.country | continent | isolation date |
|---|---|---|---|---|---|---|
| 12580 | soil | Ito City | Japan | JPN | Asia | |
| 67770 | Soil | Kawana, Ito City, Shizuoka Pref. | Japan | JPN | Asia | |
| 116661 | Environment, Soil | Kawana, Ito | Japan | JPN | Asia | 1978 |
isolation source categories
- Cat1: #Environmental
- Cat2: #Terrestrial
- Cat3: #Soil
taxonmaps
- @ref: 69479
- File name: preview.99_6006.png
- url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_15;96_102;97_109;98_1613;99_6006&stattab=map
- Last taxonomy: Streptomyces
- 16S sequence: AB184632
- Sequence Identity:
- Total samples: 690
- soil counts: 600
- aquatic counts: 30
- animal counts: 51
- plant counts: 9
Safety information
risk assessment
| @ref | biosafety level | biosafety level comment |
|---|---|---|
| 12580 | 1 | Risk group (German classification) |
| 20195 | 1 | German classification |
| 116661 | 1 | Risk group (French classification) |
Sequence information
16S sequences
| @ref | description | accession | length | database | NCBI tax ID |
|---|---|---|---|---|---|
| 20218 | Streptomyces avermitilis (Streptomyces avermectinius) gene for 16S rRNA, partial sequence | AB078897 | 1485 | ena | 227882 |
| 20218 | Streptomyces avermitilis gene for 16S rRNA, partial sequence, strain: NBRC 14893 | AB184632 | 1474 | ena | 33903 |
| 67770 | Streptomyces avermitilis 16S ribosomal RNA gene, complete sequence | AF145223 | 1517 | ena | 33903 |
Genome sequences
| @ref | description | accession | assembly level | database | NCBI tax ID |
|---|---|---|---|---|---|
| 66792 | Streptomyces avermitilis MA-4680 = NBRC 14893 | GCA_000009765 | complete | ncbi | 227882 |
| 66792 | Streptomyces avermitilis MA-4680 | 227882.9 | complete | patric | 227882 |
| 66792 | Streptomyces avermitilis MA-4680 = NBRC 14893 | 227882.28 | wgs | patric | 227882 |
| 66792 | Streptomyces avermitilis MA-4680 = NBRC 14893 | 227882.48 | plasmid | patric | 227882 |
| 66792 | Streptomyces avermitilis strain ATCC 31267 | 33903.30 | wgs | patric | 33903 |
| 66792 | Streptomyces avermitilis strain DSM 46492 | 33903.11 | wgs | patric | 33903 |
| 66792 | Streptomyces avermitilis strain NBRC 14893 | 33903.29 | wgs | patric | 33903 |
| 66792 | Streptomyces avermitilis MA-4680 | 637000304 | complete | img | 227882 |
| 66792 | Streptomyces avermitilis MA-4680, NBRC 14893 | 2609460021 | draft | img | 227882 |
| 66792 | Streptomyces avermitilis DSM 46492 | 2816332348 | draft | img | 33903 |
| 66792 | Streptomyces avermitilis MA-4680 | 2711768182 | draft | img | 227882 |
| 67770 | Streptomyces avermitilis MA-4680 = NBRC 14893 | GCA_000764715 | scaffold | ncbi | 227882 |
| 67770 | Streptomyces avermitilis NBRC 14893 | GCA_005405965 | contig | ncbi | 33903 |
| 67770 | Streptomyces avermitilis ATCC 31267 | GCA_005405985 | contig | ncbi | 33903 |
| 67770 | Streptomyces avermitilis MA-4680 = NBRC 14893 | GCA_000968255 | scaffold | ncbi | 227882 |
| 67770 | Streptomyces avermitilis DSM 46492 | GCA_001514135 | scaffold | ncbi | 33903 |
| 66792 | Streptomyces avermitilis MA-4680 = NBRC 14893 | GCA_029277425 | complete | ncbi | 227882 |
GC content
| @ref | GC-content | method |
|---|---|---|
| 67770 | 70.7 | genome sequence analysis |
| 67770 | 70.3 | high performance liquid chromatography (HPLC) |
Genome-based predictions
predictions
| trait | prediction | confidence | training_data |
|---|---|---|---|
| spore-forming | yes | 100 | no |
| motile | no | 93.857 | no |
| motile | no | 93.857 | no |
| flagellated | no | 97.973 | no |
| flagellated | no | 97.973 | no |
| gram-positive | yes | 87.632 | no |
| gram-positive | yes | 87.632 | no |
| anaerobic | no | 99.341 | no |
| anaerobic | no | 99.341 | no |
| halophile | no | 94.918 | no |
| halophile | no | 94.918 | no |
| spore-forming | yes | 94.273 | no |
| spore-forming | yes | 94.273 | no |
| glucose-util | yes | 91.046 | yes |
| glucose-util | yes | 91.046 | yes |
| aerobic | yes | 93.76 | no |
| aerobic | yes | 93.76 | no |
| thermophile | no | 97.826 | yes |
| thermophile | no | 97.826 | yes |
| glucose-ferment | no | 89.906 | no |
| glucose-ferment | no | 89.906 | no |
External links
@ref: 12580
culture collection no.: DSM 46492, ATCC 31267, CIP 107838, FERM P-4027, IMET 43778, JCM 5070, KCC S-1070, NRRL 8165, BCRC 12382, CECT 3280, CGMCC 4.1807, CGMCC 4.2072, IFO 14893, KCTC 9063, KCTC 9698, NBIMCC 3394, NBRC 14893, NCIMB 12804, VKM Ac-1301, VTT E-042732
straininfo link
- @ref: 85275
- straininfo: 39972
literature
| topic | Pubmed-ID | title | authors | journal | DOI | year | mesh | topic2 |
|---|---|---|---|---|---|---|---|---|
| Metabolism | 464561 | Avermectins, new family of potent anthelmintic agents: producing organism and fermentation. | Burg RW, Miller BM, Baker EE, Birnbaum J, Currie SA, Hartman R, Kong YL, Monaghan RL, Olson G, Putter I, Tunac JB, Wallick H, Stapley EO, Oiwa R, Omura S | Antimicrob Agents Chemother | 10.1128/AAC.15.3.361 | 1979 | Anthelmintics/analysis/*metabolism, Disaccharides/metabolism, Fermentation, Ivermectin/analogs & derivatives, Lactones/*metabolism, Streptomyces/classification/isolation & purification/*metabolism, Time Factors | Phylogeny |
| Metabolism | 1796092 | [Avermectins: biotechnological features of the producing strain of Streptomyces avermitilis VKM As 1301]. | Chermenskii DN, Adanin VM, Driniaev VA, Kovalev VN, Golovleva LA | Prikl Biokhim Mikrobiol | 1991 | Culture Media, Glucose/metabolism, Ivermectin/*analogs & derivatives/metabolism, Streptomyces/growth & development/*metabolism | Cultivation | |
| Phylogeny | 12508861 | Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. | Kim SB, Goodfellow M | Int J Syst Evol Microbiol | 10.1099/00207713-52-6-2011 | 2002 | Anthelmintics/*metabolism, DNA, Bacterial/genetics, DNA, Ribosomal/genetics, Ivermectin/*analogs & derivatives/*metabolism, Molecular Sequence Data, Phenotype, Phylogeny, RNA, Bacterial/genetics, RNA, Ribosomal, 16S/genetics, Species Specificity, Streptomyces/*classification/genetics/*metabolism, Terminology as Topic | Metabolism |
| Phylogeny | 12508884 | Streptomyces avermectinius sp. nov., an avermectin-producing strain. | Takahashi Y, Matsumoto A, Seino A, Ueno J, Iwai Y, Omura S | Int J Syst Evol Microbiol | 10.1099/00207713-52-6-2163 | 2002 | Anthelmintics/metabolism, DNA, Bacterial/genetics, DNA, Ribosomal/genetics, Ivermectin/*analogs & derivatives/metabolism, Microscopy, Electron, Scanning, Molecular Sequence Data, Nucleic Acid Hybridization, Phenotype, Phylogeny, RNA, Bacterial/genetics, RNA, Ribosomal, 16S/genetics, Streptomyces/*classification/genetics/metabolism | Metabolism |
| Metabolism | 12571055 | Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. | Hwang YS, Kim ES, Biro S, Choi CY | Appl Environ Microbiol | 10.1128/AEM.69.2.1263-1269.2003 | 2003 | Bacterial Proteins/*genetics/metabolism, *Cloning, Molecular, DNA, Bacterial/genetics, *Gene Expression Regulation, Bacterial, Genomic Library, Ivermectin/*analogs & derivatives/*metabolism, Molecular Sequence Data, Mutation, Open Reading Frames, Pigments, Biological/metabolism, Sequence Analysis, DNA, Streptomyces/genetics/*metabolism | Enzymology |
| Metabolism | 16448189 | Regiospecific flavonoid 7-O-methylation with Streptomyces avermitilis O-methyltransferase expressed in Escherichia coli. | Kim BG, Jung BR, Lee Y, Hur HG, Lim Y, Ahn JH | J Agric Food Chem | 10.1021/jf0522715 | 2006 | Amino Acid Sequence, Escherichia coli/*genetics, Flavanones/metabolism, Flavonoids/*metabolism, *Gene Expression, Genistein/metabolism, Isoflavones/metabolism, Kaempferols/metabolism, Methylation, Methyltransferases/chemistry/*genetics/*metabolism, Molecular Sequence Data, Quercetin/metabolism, Sequence Alignment, Streptomyces/*enzymology | Genetics |
| Metabolism | 17090926 | Characterization of an exo-beta-1,3-D-galactanase from Streptomyces avermitilis NBRC14893 acting on arabinogalactan-proteins. | Ichinose H, Kotake T, Tsumuraya Y, Kaneko S | Biosci Biotechnol Biochem | 10.1271/bbb.60365 | 2006 | Galactose/metabolism, Gene Expression, Glycoside Hydrolases/genetics/isolation & purification/*metabolism, Hydrolysis, Mucoproteins/*metabolism, Plant Proteins/metabolism, Recombinant Proteins/genetics/isolation & purification/metabolism, Streptomyces/*enzymology/genetics, Substrate Specificity | Enzymology |
| Enzymology | 17436620 | [Cloning of bldAa and the effect on morphological differentiation and avermectins production in Streptomyces avermitilis NRRL8165]. | Tao WX, Wu J, Deng ZX, Tao MF | Wei Sheng Wu Xue Bao | 2007 | Cloning, Molecular, Codon, Ivermectin/*analogs & derivatives/metabolism, RNA, Bacterial/*genetics, RNA, Transfer, Leu/*genetics, Streptomyces/cytology/genetics/*metabolism | Metabolism | |
| Metabolism | 18050961 | Comparative transcriptome analysis for avermectin overproduction via Streptomyces avermitilis microarray system. | Im JH, Kim MG, Kim ES | J Microbiol Biotechnol | 2007 | Antiparasitic Agents/chemistry/*metabolism, Bacterial Proteins/genetics/*metabolism, *Gene Expression Profiling, Gene Expression Regulation, Bacterial, Genome, Bacterial, Ivermectin/*analogs & derivatives/chemistry/metabolism, Oligonucleotide Array Sequence Analysis/*methods, Polyketide Synthases/genetics/metabolism, Streptomyces/genetics/*metabolism, *Up-Regulation | Transcriptome | |
| Enzymology | 18310439 | Characterization of an endo-beta-1,6-Galactanase from Streptomyces avermitilis NBRC14893. | Ichinose H, Kotake T, Tsumuraya Y, Kaneko S | Appl Environ Microbiol | 10.1128/AEM.01733-07 | 2008 | Amino Acid Motifs, Amino Acid Sequence, Cloning, Molecular, DNA, Bacterial/chemistry/genetics, Escherichia coli/genetics, Fungal Proteins, Galactans/pharmacology, Galactose/metabolism, Gene Expression, Glycoside Hydrolases/genetics, Kinetics, Lycopersicon esculentum, Molecular Sequence Data, Oligosaccharides/metabolism, Open Reading Frames, Plant Proteins/metabolism, Polysaccharides/metabolism, Protein Sorting Signals, Recombinant Proteins/isolation & purification/metabolism, Sequence Alignment, Sequence Analysis, DNA, Streptomyces/*enzymology/genetics, Substrate Specificity, beta-Galactosidase/*genetics/*metabolism | Metabolism |
| Metabolism | 18338589 | [An update of Streptomyces eukaryotic-type Ser/Thr protein kinases--a review]. | Yang X, Guan D, Wang S, Yang K | Wei Sheng Wu Xue Bao | 2008 | Bacterial Proteins/*chemistry/*genetics/metabolism, Gene Expression Regulation, Enzymologic, Protein Serine-Threonine Kinases/*chemistry/*genetics/metabolism, Protein Structure, Tertiary, Streptomyces/chemistry/*enzymology/genetics | Enzymology | |
| Metabolism | 18560830 | Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. | Chen L, Lu Y, Chen J, Zhang W, Shu D, Qin Z, Yang S, Jiang W | Appl Microbiol Biotechnol | 10.1007/s00253-008-1545-8 | 2008 | Anthraquinones/metabolism, Bacterial Proteins/genetics/*metabolism, Gene Expression, *Gene Expression Regulation, Bacterial, Ivermectin/*analogs & derivatives/metabolism, Polyketide Synthases/genetics/metabolism, Promoter Regions, Genetic, Repressor Proteins/genetics/*metabolism, Sequence Deletion, Streptomyces/enzymology/genetics/*metabolism, Transcription Factors | Enzymology |
| Enzymology | 18665359 | Characterization of a modular enzyme of exo-1,5-alpha-L-arabinofuranosidase and arabinan binding module from Streptomyces avermitilis NBRC14893. | Ichinose H, Yoshida M, Fujimoto Z, Kaneko S | Appl Microbiol Biotechnol | 10.1007/s00253-008-1551-x | 2008 | Amino Acid Sequence, Arabinose/*metabolism, Bacterial Proteins/*chemistry/genetics/metabolism, Glycoside Hydrolases/*chemistry/genetics/metabolism, Kinetics, Molecular Sequence Data, Protein Binding, Protein Structure, Tertiary, Sequence Alignment, Streptomyces/chemistry/*enzymology/genetics, Substrate Specificity | Metabolism |
| Genetics | 18997327 | Crystallization and preliminary crystallographic analysis of exo-alpha-1,5-L-arabinofuranosidase from Streptomyces avermitilis NBRC14893. | Fujimoto Z, Ichinose H, Kaneko S | Acta Crystallogr Sect F Struct Biol Cryst Commun | 10.1107/S1744309108029692 | 2008 | Bacterial Proteins/*chemistry, Crystallization/*methods, Crystallography, X-Ray, Glycoside Hydrolases/*chemistry, Molecular Sequence Data, Streptomyces/*enzymology, Synchrotrons, X-Ray Diffraction | Enzymology |
| Enzymology | 19060411 | Stereoselective reduction of carbonyl compounds with Actinomycete: purification and characterization of three alpha-keto ester reductases from Streptomyces avermitilis. | Ishihara K, Kato C, Yamaguchi H, Iwai R, Yoshida M, Ikeda N, Hamada H, Masuoka N, Nakajima N | Biosci Biotechnol Biochem | 10.1271/bbb.80537 | 2008 | Amino Acid Sequence, Enzyme Stability, Esters/*chemistry/*metabolism, Hydrogen-Ion Concentration, Ketones/*chemistry, Kinetics, Molecular Sequence Data, Molecular Weight, Oxidation-Reduction, Oxidoreductases/chemistry/*isolation & purification/*metabolism, Stereoisomerism, Streptomyces/*enzymology, Substrate Specificity, Temperature | Metabolism |
| Metabolism | 19149180 | [Effect on production of avermectins of spore pigment biosynthesis in Streptomyces avermitilis NRRL8165]. | Zhu J, Tao M | Sheng Wu Gong Cheng Xue Bao | 2008 | Bacterial Proteins/*biosynthesis/genetics/metabolism, Cloning, Molecular, Ivermectin/*analogs & derivatives/metabolism, Mutation, Peptides/genetics/metabolism, Spores, Bacterial/genetics, Streptomyces/cytology/*genetics/*metabolism | Enzymology | |
| Metabolism | 19307761 | Functional expression of SAV3818, a putative TetR-family transcriptional regulatory gene from Streptomyces avermitilis, stimulates antibiotic production in Streptomyces species. | Duong CT, Lee HN, Choi SS, Lee SY, Kim ES | J Microbiol Biotechnol | 10.4014/jmb.0806.387 | 2009 | Anthraquinones/metabolism, Anti-Bacterial Agents/*biosynthesis, Bacterial Proteins/genetics/*metabolism, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Genes, Bacterial, *Genes, Regulator, Ivermectin/analogs & derivatives/metabolism, Streptomyces/*genetics/metabolism | Biotechnology |
| Metabolism | 19424691 | Analysis of neutral lipid biosynthesis in Streptomyces avermitilis MA-4680 and characterization of an acyltransferase involved herein. | Kaddor C, Biermann K, Kalscheuer R, Steinbuchel A | Appl Microbiol Biotechnol | 10.1007/s00253-009-2018-4 | 2009 | Acyltransferases/*chemistry/genetics/metabolism, Amino Acid Sequence, Bacterial Proteins/*chemistry/genetics/metabolism, Cloning, Molecular, Lipids/*biosynthesis/chemistry, Molecular Sequence Data, Sequence Alignment, Streptomyces/chemistry/*enzymology/metabolism, Substrate Specificity | Enzymology |
| Enzymology | 19478450 | Crystallization and preliminary crystallographic analysis of beta-L-arabinopyranosidase from Streptomyces avermitilis NBRC14893. | Fujimoto Z, Ichinose H, Harazono K, Honda M, Uzura A, Kaneko S | Acta Crystallogr Sect F Struct Biol Cryst Commun | 10.1107/S1744309109017230 | 2009 | Amino Acid Sequence, Catalytic Domain, Cloning, Molecular, Crystallization, *Crystallography, X-Ray, Data Collection, Genes, Bacterial, Glycoside Hydrolases/*chemistry/genetics, Molecular Sequence Data, Plasmids, Protein Structure, Tertiary, Recombinant Proteins/chemistry, Statistics as Topic, Streptomyces/*enzymology, Synchrotrons, Transformation, Bacterial, X-Ray Diffraction | Genetics |
| Enzymology | 19577190 | Regioselective hydroxylation of isoflavones by Streptomyces avermitilis MA-4680. | Roh C, Seo SH, Choi KY, Cha M, Pandey BP, Kim JH, Park JS, Kim DH, Chang IS, Kim BG | J Biosci Bioeng | 10.1016/j.jbiosc.2009.02.021 | 2009 | Biotransformation, Cytochrome P-450 Enzyme Inhibitors, Detergents/chemistry, Enzyme Inhibitors/pharmacology, Gas Chromatography-Mass Spectrometry, Hydroxylation, Isoflavones/*metabolism/pharmacokinetics, Kinetics, Magnetic Resonance Spectroscopy, Streptomyces/*metabolism | Metabolism |
| Transcriptome | 19656197 | Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis. | Chen L, Chen J, Jiang Y, Zhang W, Jiang W, Lu Y | FEMS Microbiol Lett | 10.1111/j.1574-6968.2009.01721.x | 2009 | Anti-Bacterial Agents/biosynthesis, Bacterial Proteins/biosynthesis, Fatty Acids/biosynthesis, Gene Deletion, *Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction, Streptomyces/*physiology, Transcription Factors/genetics/*physiology | |
| Metabolism | 20352288 | Overexpression of ribosome recycling factor causes increased production of avermectin in Streptomyces avermitilis strains. | Li L, Guo J, Wen Y, Chen Z, Song Y, Li J | J Ind Microbiol Biotechnol | 10.1007/s10295-010-0710-0 | 2010 | Bacterial Proteins/*genetics/metabolism, *Gene Expression Regulation, Bacterial, Ivermectin/*analogs & derivatives/metabolism, Ribosomal Proteins/*genetics/metabolism, Streptomyces/genetics/*metabolism | Biotechnology |
| Metabolism | 20655739 | Enhancement of avermectin and ivermectin production by overexpression of the maltose ATP-binding cassette transporter in Streptomyces avermitilis. | Li M, Chen Z, Zhang X, Song Y, Wen Y, Li J | Bioresour Technol | 10.1016/j.biortech.2010.06.132 | 2010 | ATP-Binding Cassette Transporters/*metabolism, Carbon/pharmacology, Culture Media/chemistry, Gene Deletion, Gene Expression Regulation, Bacterial/drug effects, Genes, Bacterial/genetics, Ivermectin/*analogs & derivatives/*metabolism, Maltose/*metabolism, Oligomycins/metabolism, RNA, Messenger/genetics/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Starch/metabolism, Streptomyces/drug effects/genetics/growth & development/*metabolism | Pathogenicity |
| Metabolism | 20824676 | Necessary and sufficient conditions for the asymmetric synthesis of chiral amines using omega-aminotransferases. | Seo JH, Kyung D, Joo K, Lee J, Kim BG | Biotechnol Bioeng | 10.1002/bit.22930 | 2011 | Acetophenones/metabolism, Agrobacterium tumefaciens/enzymology, Alanine/*metabolism, Amines/*metabolism, Isomerism, L-Lactate Dehydrogenase/metabolism, Molecular Conformation, Pyridoxal Phosphate/*metabolism, Pyridoxamine/*analogs & derivatives/metabolism, Streptomyces/enzymology, Transaminases/*metabolism, Vibrio/enzymology | Enzymology |
| Enzymology | 20845078 | Expression and identification of a thermostable malate dehydrogenase from multicellular prokaryote Streptomyces avermitilis MA-4680. | Wang ZD, Wang BJ, Ge YD, Pan W, Wang J, Xu L, Liu AM, Zhu GP | Mol Biol Rep | 10.1007/s11033-010-0273-1 | 2010 | Amino Acid Sequence, Biocatalysis/drug effects, Blotting, Western, Electrophoresis, Polyacrylamide Gel, Enzyme Activation/drug effects, Enzyme Stability/drug effects, Hydrogen-Ion Concentration/drug effects, Ions, Kinetics, Malate Dehydrogenase/chemistry/isolation & purification/*metabolism, Malates/pharmacology, Metals/pharmacology, Molecular Sequence Data, Oxaloacetic Acid/metabolism, Prokaryotic Cells/*cytology/drug effects/*enzymology, Recombinant Proteins/metabolism, Sequence Alignment, Sequence Homology, Amino Acid, Streptomyces/*cytology/drug effects/*enzymology, Temperature | Pathogenicity |
| Enzymology | 20888207 | Superoxide dismutase (SOD) genes in Streptomyces peucetius: effects of SODs on secondary metabolites production. | Kanth BK, Jnawali HN, Niraula NP, Sohng JK | Microbiol Res | 10.1016/j.micres.2010.07.003 | 2010 | Anti-Bacterial Agents/biosynthesis, Biomass, Cloning, Molecular, DNA, Bacterial/chemistry/genetics, Gene Expression, Gene Expression Profiling, *Metabolome, Molecular Sequence Data, Sequence Analysis, DNA, Streptomyces/*enzymology/genetics/*metabolism, Superoxide Dismutase/*genetics/*metabolism | Genetics |
| Metabolism | 20890103 | Characterization of an O-methyltransferase from Streptomyces avermitilis MA-4680. | Yoon Y, Park Y, Lee Y, Yi YS, Jo G, Park JC, Ahn JH, Lim Y | J Microbiol Biotechnol | 10.4014/jmb.1005.05012 | 2010 | Acyl Coenzyme A/metabolism, Amino Acid Sequence, Caffeic Acids/metabolism, Flavones/metabolism, Flavonoids/metabolism, Magnesium/physiology, Methyltransferases/chemistry/*genetics/*metabolism, Molecular Sequence Data, Recombinant Proteins/metabolism, Sequence Alignment, Streptomyces/*enzymology/genetics, Substrate Specificity | Genetics |
| Enzymology | 21104016 | Heteroexpression and characterization of a monomeric isocitrate dehydrogenase from the multicellular prokaryote Streptomyces avermitilis MA-4680. | Wang A, Cao ZY, Wang P, Liu AM, Pan W, Wang J, Zhu GP | Mol Biol Rep | 10.1007/s11033-010-0486-3 | 2010 | Amino Acid Sequence, Electrophoresis, Polyacrylamide Gel, Enzyme Activation/drug effects, *Gene Expression/drug effects, Hydrogen-Ion Concentration/drug effects, Indicators and Reagents/pharmacology, Ions, Isocitrate Dehydrogenase/chemistry/isolation & purification/*metabolism, Kinetics, Metals/pharmacology, Molecular Sequence Data, Molecular Weight, Prokaryotic Cells/drug effects/*enzymology, Recombinant Proteins/chemistry/metabolism, Sequence Alignment, Sequence Homology, Amino Acid, Streptomyces/drug effects/*enzymology, Temperature | Pathogenicity |
| Metabolism | 21268904 | [Effect of inorganic salts on the conjugation and heterologous expression of actinorhodin in Streptomyces avermitilis]. | Yu J, Tao M | Wei Sheng Wu Xue Bao | 2010 | Anthraquinones/metabolism, Anti-Bacterial Agents/*metabolism, Conjugation, Genetic/*drug effects, Gene Expression Regulation, Bacterial/*drug effects, Plasmids/genetics, Salts/*pharmacology, Streptomyces/*drug effects/genetics/metabolism | Pathogenicity | |
| Metabolism | 22038854 | Improving fatty acid production in Escherichia coli through the overexpression of malonyl coA-acyl carrier protein transacylase. | Zhang X, Agrawal A, San KY | Biotechnol Prog | 10.1002/btpr.716 | 2011 | Acyl-Carrier Protein S-Malonyltransferase/genetics/*metabolism, Amino Acid Sequence, Clostridium acetobutylicum/enzymology/genetics, DNA Primers, Escherichia coli/*enzymology/*genetics, Escherichia coli Proteins/genetics/*metabolism, Fatty Acid Synthase, Type II/genetics/metabolism, Fatty Acids/*biosynthesis, Gene Expression Regulation, Bacterial, Malonyl Coenzyme A/metabolism, Molecular Sequence Data, Plasmids, Streptomyces/enzymology/genetics | Enzymology |
| Metabolism | 22556031 | Characterization of new class III lantibiotics--erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing. | Voller GH, Krawczyk JM, Pesic A, Krawczyk B, Nachtigall J, Sussmuth RD | Chembiochem | 10.1002/cbic.201200118 | 2012 | Alanine/*analogs & derivatives/chemistry/genetics/metabolism, Amino Acid Sequence, Anti-Bacterial Agents/*chemistry/metabolism, Bacteriocins/*chemistry/genetics/metabolism, Genes, Bacterial, Mass Spectrometry, Molecular Sequence Data, Saccharopolyspora/*chemistry/genetics/metabolism, Streptomyces/*chemistry/genetics/metabolism, Streptomyces griseus/*chemistry/genetics/metabolism, Sulfides/*chemistry/metabolism | Genetics |
| Enzymology | 22941084 | Characterization of an endo-processive-type xyloglucanase having a beta-1,4-glucan-binding module and an endo-type xyloglucanase from Streptomyces avermitilis. | Ichinose H, Araki Y, Michikawa M, Harazono K, Yaoi K, Karita S, Kaneko S | Appl Environ Microbiol | 10.1128/AEM.01762-12 | 2012 | Catalytic Domain, Cloning, Molecular, Enzyme Stability, Glycoside Hydrolases/chemistry/genetics/*metabolism, Hydrogen-Ion Concentration, Molecular Weight, Oligosaccharides/metabolism, Recombinant Proteins/genetics/metabolism, Streptomyces/*enzymology/genetics, Tamarindus/metabolism, Temperature | Metabolism |
| Metabolism | 23579768 | Overexpression of metK shows different effects on avermectin production in various Streptomyces avermitilis strains. | Zhao X, Wang Q, Guo W, Cai Y, Wang C, Wang S, Xiang S, Song Y | World J Microbiol Biotechnol | 10.1007/s11274-013-1350-0 | 2013 | Cloning, Molecular, *Gene Expression, Genetic Vectors, Ivermectin/*analogs & derivatives/metabolism, Metabolic Engineering, Methionine Adenosyltransferase/*genetics/*metabolism, Plasmids, Streptomyces/*genetics/*metabolism | Enzymology |
| Metabolism | 23967193 | A novel TetR family transcriptional regulator, SAV576, negatively controls avermectin biosynthesis in Streptomyces avermitilis. | Guo J, Zhang X, Luo S, He F, Chen Z, Wen Y, Li J | PLoS One | 10.1371/journal.pone.0071330 | 2013 | Bacterial Proteins/*genetics/*metabolism, Base Sequence, Binding Sites, Chromosome Mapping, Chromosomes, Bacterial, DNA, Intergenic, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Gene Order, Ivermectin/*analogs & derivatives/metabolism, Molecular Sequence Data, Mutation, Promoter Regions, Genetic, Protein Binding, Streptomyces/*genetics/*metabolism, Trans-Activators/*genetics/*metabolism, Transcription, Genetic | Genetics |
| Metabolism | 24220792 | Engineering of the TetR family transcriptional regulator SAV151 and its target genes increases avermectin production in Streptomyces avermitilis. | He F, Liu W, Sun D, Luo S, Chen Z, Wen Y, Li J | Appl Microbiol Biotechnol | 10.1007/s00253-013-5348-1 | 2013 | Antiparasitic Agents/*metabolism, Chromatin Immunoprecipitation, DNA, Bacterial/genetics/metabolism, Electrophoretic Mobility Shift Assay, Gene Deletion, Gene Expression, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Genetic Complementation Test, Ivermectin/*analogs & derivatives/metabolism, *Metabolic Engineering, Promoter Regions, Genetic, Protein Binding, Real-Time Polymerase Chain Reaction, Streptomyces/*genetics/*metabolism, Transcription Factors/*genetics/*metabolism | Biotechnology |
| Metabolism | 25104027 | Recent advances in biochemistry and biotechnological synthesis of avermectins and their derivatives. | Thuan NH, Pandey RP, Sohng JK | Appl Microbiol Biotechnol | 10.1007/s00253-014-5926-x | 2014 | Biochemistry/*trends, Biotechnology/*trends, Ivermectin/*analogs & derivatives/chemistry/metabolism, Multigene Family, Mycobacterium tuberculosis/metabolism, Streptomyces/metabolism | Biotechnology |
| Genetics | 25919614 | Hybrid De Novo Genome Assembly Using MiSeq and SOLiD Short Read Data. | Ikegami T, Inatsugi T, Kojima I, Umemura M, Hagiwara H, Machida M, Asai K | PLoS One | 10.1371/journal.pone.0126289 | 2015 | Aspergillus oryzae/*genetics, Base Sequence, *Genome, Bacterial, *Genome, Fungal, High-Throughput Nucleotide Sequencing/*methods, Molecular Sequence Data, Multigene Family, Open Reading Frames/genetics, Reference Standards, Reproducibility of Results, Streptomyces/*genetics | |
| Genetics | 26527303 | Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor. | Li S, Wang W, Li X, Fan K, Yang K | Sci Rep | 10.1038/srep15840 | 2015 | Cluster Analysis, Gene Expression Profiling/*methods/standards, *Gene Expression Regulation, Bacterial, Genes, Bacterial/*genetics, Genome, Bacterial/*genetics, Oligonucleotide Array Sequence Analysis/methods/standards, Reference Standards, Reverse Transcriptase Polymerase Chain Reaction/methods/standards, Streptomyces coelicolor/*genetics | Transcriptome |
| Metabolism | 28303934 | Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis. | Liu X, Cheng Y, Lyu M, Wen Y, Song Y, Chen Z, Li J | Sci Rep | 10.1038/srep44567 | 2017 | Aerobiosis/genetics, Binding Sites, Cell Differentiation/*genetics, Cell Respiration/genetics, DNA-Binding Proteins/*genetics/metabolism, Gene Expression Regulation, Bacterial, Gene Products, rex/*genetics/metabolism, Ivermectin/*analogs & derivatives/metabolism, Oxidation-Reduction, Promoter Regions, Genetic, Protein Binding, Streptomyces/genetics/metabolism, Transcription, Genetic | Biotechnology |
| Metabolism | 28522606 | Structural analysis of the dual-function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an alpha,beta-unsaturated thioester. | Chisuga T, Miyanaga A, Kudo F, Eguchi T | J Biol Chem | 10.1074/jbc.M117.792549 | 2017 | Bacterial Proteins/*chemistry/genetics/metabolism, Catalysis, Glycine/chemistry/metabolism, Mutagenesis, Site-Directed, Protein Structure, Secondary, Streptomyces/*enzymology/genetics, Sulfides/chemistry/metabolism, Thiolester Hydrolases/*chemistry/genetics/metabolism | Enzymology |
| 29062962 | Heterologous expression of Avermectins biosynthetic gene cluster by construction of a Bacterial Artificial Chromosome library of the producers. | Deng Q, Zhou L, Luo M, Deng Z, Zhao C | Synth Syst Biotechnol | 10.1016/j.synbio.2017.03.001 | 2017 | |||
| Metabolism | 29184989 | Enhanced avermectin production by Streptomyces avermitilis ATCC 31267 using high-throughput screening aided by fluorescence-activated cell sorting. | Cao X, Luo Z, Zeng W, Xu S, Zhao L, Zhou J | Appl Microbiol Biotechnol | 10.1007/s00253-017-8658-x | 2017 | Antiprotozoal Agents/*metabolism, Bioreactors, Flow Cytometry, Fluorescent Dyes, Gene Expression Regulation, Bacterial, High-Throughput Screening Assays/*methods, Ivermectin/*analogs & derivatives/metabolism, Mutagenesis, Spores, Streptomyces/genetics/*metabolism | Biotechnology |
| Metabolism | 30241528 | Development of a strictly regulated xylose-induced expression system in Streptomyces. | Noguchi Y, Kashiwagi N, Uzura A, Ogino C, Kondo A, Ikeda H, Sota M | Microb Cell Fact | 10.1186/s12934-018-0991-y | 2018 | Acetylglucosaminidase/biosynthesis, Aldose-Ketose Isomerases/genetics, Gene Expression Regulation, Bacterial, Metabolic Engineering/*methods, Promoter Regions, Genetic, Streptomyces/*genetics/metabolism | |
| Phylogeny | 34410901 | Streptomyces xanthii sp. nov. and Streptomyces roseirectus sp. nov. isolated from a Chinese medicinal plant. | Hu S, Wang Y, Wang J, Liu K, Tang X, Gao J | Int J Syst Evol Microbiol | 10.1099/ijsem.0.004962 | 2021 | Bacterial Typing Techniques, Base Composition, China, DNA, Bacterial/genetics, Fatty Acids/chemistry, Nucleic Acid Hybridization, *Phylogeny, Plants, Medicinal/microbiology, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNA, *Streptomyces/classification/isolation & purification, Xanthium/*microbiology | Transcriptome |
| Metabolism | 35062881 | Genome-scale analysis of genetic regulatory elements in Streptomyces avermitilis MA-4680 using transcript boundary information. | Lee Y, Lee N, Hwang S, Kim W, Cho S, Palsson BO, Cho BK | BMC Genomics | 10.1186/s12864-022-08314-0 | 2022 | Bacterial Proteins/genetics/metabolism, Gene Expression Regulation, Bacterial, Ivermectin, Multigene Family, Sigma Factor, *Streptomyces/genetics/metabolism, Transcription Initiation Site |
Reference
| @id | authors | catalogue | doi/url | title | journal | pubmed |
|---|---|---|---|---|---|---|
| 12580 | Curators of the DSMZ | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 46492) | https://www.dsmz.de/collection/catalogue/details/culture/DSM-46492 | |||
| 20195 | Wink, J. | http://www.dsmz.de/microorganisms/wink_pdf/DSM46492.pdf | Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig | |||
| 20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M. | 10.1099/ijsem.0.004332 | List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ | |||
| 20218 | Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P. | 10.1016/j.syapm.2013.11.002 | StrainInfo introduces electronic passports for microorganisms. | Syst Appl Microbiol. 37: 42-50 2014 | 24321274 | |
| 36514 | Curators of the CIP | https://brclims.pasteur.fr/brcWeb/souche/detail/1/5393 | ||||
| 66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |||
| 67770 | Curators of the JCM | https://jcm.brc.riken.jp/en/ | ||||
| 68368 | Automatically annotated from API 20E | |||||
| 68382 | Automatically annotated from API zym | |||||
| 69479 | João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich. | https://microbeatlas.org/ | MicrobeAtlas 1.0 beta | |||
| 69480 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |||
| 69481 | Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch | 10.21203/rs.3.rs-2527258/v1 | Predictions based on the model GenomeNet Sporulation v. 1 | |||
| 85275 | Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J. | 10.60712/SI-ID39972.1 | StrainInfo: A central database for resolving microbial strain identifiers | |||
| 116661 | Curators of the CIP | Collection of Institut Pasteur (CIP 107838) | https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20107838 |