Strain identifier
BacDive ID: 15430
Type strain: 
Species: Streptomyces noursei
Strain Designation: 48240
Strain history: KCC S-0922 <-- ATCC 11455 <-- J. M. Coffey 48240.
NCBI tax ID(s): 316284 (strain), 1971 (species)
version 8.1 (current version)
General
@ref: 9587
BacDive-ID: 15430
DSM-Number: 40635
keywords: genome sequence, 16S sequence, Bacteria, spore-forming, mesophilic, antibiotic compound production
description: Streptomyces noursei 48240 is a spore-forming, mesophilic bacterium that produces antibiotic compounds and was isolated from soil.
NCBI tax id
| NCBI tax id | Matching level |
|---|---|
| 1971 | species |
| 316284 | strain |
strain history
| @ref | history |
|---|---|
| 9587 | <- E.J. Backus, Lederle Labs., D 17 <- ATCC <- J.M. Coffey, 48240 |
| 67770 | KCC S-0922 <-- ATCC 11455 <-- J. M. Coffey 48240. |
doi: 10.13145/bacdive15430.20230509.8.1
Name and taxonomic classification
LPSN
- @ref: 20215
- description: domain/bacteria
- keyword: phylum/actinomycetota
- domain: Bacteria
- phylum: Actinomycetota
- class: Actinomycetes
- order: Kitasatosporales
- family: Streptomycetaceae
- genus: Streptomyces
- species: Streptomyces noursei
- full scientific name: Streptomyces noursei Brown et al. 1953 (Approved Lists 1980)
synonyms
- @ref: 20215
- synonym: Streptomyces albulus
@ref: 9587
domain: Bacteria
phylum: Actinobacteria
class: Actinobacteria
order: Actinomycetales
family: Streptomycetaceae
genus: Streptomyces
species: Streptomyces noursei
full scientific name: Streptomyces noursei Brown et al. 1953 emend. Nouioui et al. 2018
strain designation: 48240
type strain: yes
Morphology
cell morphology
| @ref | motility | confidence | gram stain |
|---|---|---|---|
| 69480 | no | 95.955 | |
| 69480 | 100 | positive |
multimedia
- @ref: 9587
- multimedia content: https://www.dsmz.de/microorganisms/photos/DSM_40635.jpg
- caption: Medium 65 28°C
- intellectual property rights: © Leibniz-Institut DSMZ
Culture and growth conditions
culture medium
| @ref | name | growth | link | composition |
|---|---|---|---|---|
| 9587 | GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) | yes | https://mediadive.dsmz.de/medium/65 | Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water |
| 9587 | ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) | yes | https://mediadive.dsmz.de/medium/84 | Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water |
| 9587 | GPHF-MEDIUM (DSMZ Medium 553) | yes | https://mediadive.dsmz.de/medium/553 | Name: GPHF-MEDIUM (DSMZ Medium 553) Composition: Agar 20.0 g/l Glucose 10.0 g/l Beef extract 5.0 g/l Yeast extract 5.0 g/l Casein peptone 5.0 g/l CaCl2 x 2 H2O 0.74 g/l Distilled water |
culture temp
| @ref | growth | type | temperature | range |
|---|---|---|---|---|
| 9587 | positive | growth | 28 | mesophilic |
| 67770 | positive | growth | 28 | mesophilic |
Physiology and metabolism
spore formation
| @ref | spore formation | confidence |
|---|---|---|
| 69481 | yes | 100 |
| 69480 | yes | 100 |
compound production
| @ref | compound |
|---|---|
| 9587 | nystatin |
| 9587 | fungicidin |
| 9587 | actidione |
metabolite production
| @ref | Chebi-ID | metabolite | production |
|---|---|---|---|
| 67770 | 27641 | cycloheximide | yes |
| 67770 | 7660 | nystatin | yes |
Isolation, sampling and environmental information
isolation
| @ref | sample type | geographic location | country | origin.country | continent |
|---|---|---|---|---|---|
| 9587 | soil | Fauquier Country | USA | USA | North America |
| 67770 | Soil | Fauquier Country, VA | USA | USA | North America |
isolation source categories
- Cat1: #Environmental
- Cat2: #Terrestrial
- Cat3: #Soil
Safety information
risk assessment
- @ref: 9587
- biosafety level: 1
- biosafety level comment: Risk group (German classification)
Sequence information
16S sequences
| @ref | description | accession | length | database | NCBI tax ID |
|---|---|---|---|---|---|
| 20218 | Streptomyces noursei gene for 16S ribosomal RNA, partial sequence, strain: JCM 4922 | D44419 | 121 | ena | 1971 |
| 20218 | Streptomyces noursei strain KCTC 1083 16S ribosomal RNA gene, partial sequence | AY999827 | 1424 | ena | 1971 |
| 20218 | Streptomyces noursei gene for 16S rRNA, partial sequence, strain: NBRC 15452 | AB184678 | 1472 | ena | 1971 |
Genome sequences
| @ref | description | accession | assembly level | database | NCBI tax ID |
|---|---|---|---|---|---|
| 66792 | Streptomyces noursei ATCC 11455 | 316284.18 | complete | patric | 316284 |
| 66792 | Streptomyces noursei ATCC 11455 Genome sequencing | 2602042089 | draft | img | 316284 |
| 67770 | Streptomyces noursei ATCC 11455 | GCA_001704275 | complete | ncbi | 316284 |
GC content
- @ref: 67770
- GC-content: 71.5
- method: genome sequence analysis
Genome-based predictions
predictions
| trait | prediction | confidence | training_data |
|---|---|---|---|
| spore-forming | yes | 100 | no |
| gram-positive | yes | 89.524 | no |
| anaerobic | no | 99.276 | no |
| halophile | no | 93.72 | no |
| spore-forming | yes | 95.018 | no |
| glucose-util | yes | 91.287 | no |
| flagellated | no | 98.299 | no |
| aerobic | yes | 93.008 | no |
| thermophile | no | 97.765 | yes |
| motile | no | 93.461 | no |
| glucose-ferment | no | 91.252 | no |
External links
@ref: 9587
culture collection no.: DSM 40635, ATCC 11455, CBS 240.57, DSM 40636, DSM 41152, ETH 13473, IFO 15452, IMRU 3771, INA 0178, JCM 4922, KCC S-0922, NBRC 15452, NCIB 8593, NRRL B-1714, BCRC 12044, CECT 3240, KCTC 1083, LMG 5982, NBIMCC 3392, NCIMB 8593
straininfo link
- @ref: 84517
- straininfo: 389303
literature
| topic | Pubmed-ID | title | authors | journal | DOI | year | mesh | topic2 |
|---|---|---|---|---|---|---|---|---|
| Enzymology | 10474196 | Molecular cloning and analysis of a pleiotropic regulatory gene locus from the nystatin producer Streptomyces noursei ATCC11455. | Sekurova O, Sletta H, Ellingsen TE, Valla S, Zotchev S | FEMS Microbiol Lett | 10.1111/j.1574-6968.1999.tb13746.x | 1999 | Amino Acid Sequence, Anthraquinones/metabolism, Antifungal Agents/*biosynthesis, Bacterial Proteins/genetics, Cloning, Molecular, *DNA-Binding Proteins, Fermentation, Fungal Proteins/genetics, *Genes, Bacterial, *Genes, Regulator, Nystatin/*biosynthesis, Repressor Proteins/genetics, Sequence Analysis, DNA, Sequence Deletion, Sequence Homology, Amino Acid, Streptomyces/*genetics, *Transcription Factors | Transcriptome |
| Genetics | 10746764 | Identification of a gene cluster for antibacterial polyketide-derived antibiotic biosynthesis in the nystatin producer Streptomyces noursei ATCC 11455. | Zotchev S, Haugan K, Sekurova O, Sletta H, Ellingsen TE, Valla S | Microbiology (Reading) | 10.1099/00221287-146-3-611 | 2000 | Anti-Bacterial Agents/*biosynthesis, Gene Deletion, Gene Transfer Techniques, *Genes, Bacterial, Hydro-Lyases, Molecular Sequence Data, Multigene Family, Nystatin/*biosynthesis, Plasmids/genetics, Polymerase Chain Reaction, Streptomyces/*genetics/growth & development/metabolism | Metabolism |
| Enzymology | 10873841 | Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway. | Brautaset T, Sekurova ON, Sletta H, Ellingsen TE, StrLm AR, Valla S, Zotchev SB | Chem Biol | 10.1016/s1074-5521(00)00120-4 | 2000 | Antifungal Agents/*biosynthesis, Base Sequence, Cloning, Molecular, DNA Mutational Analysis, DNA Primers, Molecular Sequence Data, *Multigene Family, Nystatin/*biosynthesis, Sequence Analysis, DNA, Streptomyces/genetics/*metabolism | Genetics |
| Metabolism | 11217800 | Effects of nitrogen sources on cell growth and production of nystatin by Streptomyces noursei. | Jonsbu E, Ellingsen TE, Nielsen J | J Antibiot (Tokyo) | 10.7164/antibiotics.53.1354 | 2000 | Anti-Bacterial Agents/*biosynthesis, *Cell Division, Glycogen/metabolism, Nitrogen/*metabolism, Nystatin/*biosynthesis, Streptomyces/cytology/*metabolism | Biotechnology |
| Metabolism | 11499953 | Changes of in vivo fluxes through central metabolic pathways during the production of nystatin by Streptomyces noursei in batch culture. | Jonsbu E, Christensen B, Nielsen J | Appl Microbiol Biotechnol | 10.1007/s002530100613 | 2001 | Amino Acids/metabolism, Anti-Bacterial Agents/*biosynthesis, Citric Acid Cycle, Fermentation, NADP/metabolism, Nystatin/*biosynthesis, Streptomyces/*metabolism | Biotechnology |
| Biotechnology | 11911923 | The influence of carbon sources and morphology on nystatin production by Streptomyces noursei. | Jonsbu E, McIntyre M, Nielsen J | J Biotechnol | 10.1016/s0168-1656(02)00003-2 | 2002 | Anti-Bacterial Agents/*biosynthesis, Biotechnology, Carbon/*metabolism, Culture Media/pharmacology, Fermentation, Microbiological Techniques, Nystatin/*biosynthesis, Streptomyces/*growth & development/*metabolism | Metabolism |
| Metabolism | 14973031 | In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. | Sekurova ON, Brautaset T, Sletta H, Borgos SE, Jakobsen M OM, Ellingsen TE, Strom AR, Valla S, Zotchev SB | J Bacteriol | 10.1128/JB.186.5.1345-1354.2004 | 2004 | Amino Acid Sequence, Anti-Bacterial Agents/*biosynthesis, Bacterial Proteins/chemistry/genetics/metabolism, Catechol 2,3-Dioxygenase, *Dioxygenases, Gene Deletion, *Gene Expression Regulation, Bacterial, Genes, Bacterial, *Genes, Regulator, Genes, Reporter, Genetic Complementation Test, Molecular Sequence Data, Multigene Family, Nystatin/*biosynthesis, Oxygenases/genetics/metabolism, Promoter Regions, Genetic, Sequence Alignment, Streptomyces/*genetics/growth & development/metabolism | Genetics |
| Metabolism | 15504830 | Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC. | Bruheim P, Borgos SE, Tsan P, Sletta H, Ellingsen TE, Lancelin JM, Zotchev SB | Antimicrob Agents Chemother | 10.1128/AAC.48.11.4120-4129.2004 | 2004 | Anti-Bacterial Agents/*biosynthesis/pharmacology, Candida albicans/drug effects, Chromatography, High Pressure Liquid, Macrolides/*metabolism/pharmacology, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Conformation, Molecular Weight, Nystatin/chemistry/pharmacology, Polyenes/*metabolism/pharmacology, Polyketide Synthases/*biosynthesis/genetics, Recombination, Genetic, Streptomyces/*enzymology/genetics | Pathogenicity |
| Metabolism | 15990252 | An unexpected role for the putative 4'-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in Streptomyces noursei ATCC 11455. | Volokhan O, Sletta H, Sekurova ON, Ellingsen TE, Zotchev SB | FEMS Microbiol Lett | 10.1016/j.femsle.2005.05.052 | 2005 | Amino Acid Sequence, Bacterial Proteins/chemistry/*genetics/metabolism, *Gene Expression Regulation, Bacterial, Molecular Sequence Data, Nystatin/*biosynthesis, Streptomyces/*enzymology/genetics/growth & development/metabolism, Transferases (Other Substituted Phosphate Groups)/chemistry/*genetics/metabolism | Genetics |
| Metabolism | 16251298 | Nystatin biosynthesis and transport: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin. | Sletta H, Borgos SE, Bruheim P, Sekurova ON, Grasdalen H, Aune R, Ellingsen TE, Zotchev SB | Antimicrob Agents Chemother | 10.1128/AAC.49.11.4576-4583.2005 | 2005 | ATP-Binding Cassette Transporters/genetics/*physiology, Adenosine Triphosphatases/antagonists & inhibitors, Anti-Bacterial Agents/*biosynthesis, Biological Transport, Genes, Bacterial/*physiology, Multigene Family, Nystatin/*biosynthesis, Streptomyces/genetics/*metabolism, Vanadates/pharmacology | |
| Metabolism | 17905880 | Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455. | Nedal A, Sletta H, Brautaset T, Borgos SE, Sekurova ON, Ellingsen TE, Zotchev SB | Appl Environ Microbiol | 10.1128/AEM.01122-07 | 2007 | Animals, Blotting, Western, Carbohydrate Dehydrogenases/genetics/metabolism, Chromatography, High Pressure Liquid, Chromatography, Liquid, Genetic Vectors/genetics, Glycosyltransferases/genetics/metabolism, Hemolysis/drug effects, Hexosamines/*biosynthesis/chemistry/pharmacology, Horses, Mass Spectrometry, Molecular Structure, *Multigene Family, Nystatin/*biosynthesis/chemistry/pharmacology, Polymerase Chain Reaction, Recombinant Proteins/metabolism, Streptomyces/*genetics/*metabolism, Transaminases/genetics/metabolism | Enzymology |
| Phylogeny | 19060056 | Streptomyces lunalinharesii sp. nov., a chitinolytic streptomycete isolated from cerrado soil in Brazil. | de Souza RF, Coelho RR, Macrae A, Soares RM, Nery Dda C, Semedo LT, Alviano CS, Gomes RC | Int J Syst Evol Microbiol | 10.1099/ijs.0.65768-0 | 2008 | Brazil, Chitin/*metabolism, Molecular Sequence Data, Phylogeny, RNA, Ribosomal, 16S/genetics, *Soil Microbiology, Species Specificity, Streptomyces/*classification/genetics/*physiology | Genetics |
| Biotechnology | 36246390 | Production of secondary metabolites in stirred tank bioreactor co-cultures of Streptomyces noursei and Aspergillus terreus. | Boruta T, Scigaczewska A, Bizukojc M | Front Bioeng Biotechnol | 10.3389/fbioe.2022.1011220 | 2022 |
Reference
| @id | authors | catalogue | doi/url | title | journal | pubmed |
|---|---|---|---|---|---|---|
| 9587 | Curators of the DSMZ | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 40635) | https://www.dsmz.de/collection/catalogue/details/culture/DSM-40635 | |||
| 20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M. | 10.1099/ijsem.0.004332 | List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ | |||
| 20218 | Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P. | 10.1016/j.syapm.2013.11.002 | StrainInfo introduces electronic passports for microorganisms. | Syst Appl Microbiol. 37: 42-50 2014 | 24321274 | |
| 66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |||
| 67770 | Curators of the JCM | https://jcm.brc.riken.jp/en/ | ||||
| 69480 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |||
| 69481 | Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch | 10.21203/rs.3.rs-2527258/v1 | Predictions based on the model GenomeNet Sporulation v. 1 | |||
| 84517 | Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J. | 10.60712/SI-ID389303.1 | StrainInfo: A central database for resolving microbial strain identifiers |