Strain identifier

BacDive ID: 154

Type strain: Yes

Species: Actinomyces naeslundii

Strain history: CIP <- 1988, NCTC <- 1962, L. Pine

NCBI tax ID(s): 1655 (species)

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General

@ref: 10673

BacDive-ID: 154

DSM-Number: 43013

keywords: genome sequence, 16S sequence, Bacteria, anaerobe, mesophilic, human pathogen

description: Actinomyces naeslundii DSM 43013 is an anaerobe, mesophilic human pathogen that was isolated from human sinus.

NCBI tax id

  • NCBI tax id: 1655
  • Matching level: species

strain history

@refhistory
10673<- M.A. Gerencser, WVU 45 <- ATCC <- A. Howell, NIH, 279 <- L. Thompson
67770N. Maeda TPR-13 <-- ATCC 12104 <-- A. Howell, Jr. 279 <-- L. Thompson.
121221CIP <- 1988, NCTC <- 1962, L. Pine

doi: 10.13145/bacdive154.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/actinomycetota
  • domain: Bacteria
  • phylum: Actinomycetota
  • class: Actinomycetes
  • order: Actinomycetales
  • family: Actinomycetaceae
  • genus: Actinomyces
  • species: Actinomyces naeslundii
  • full scientific name: Actinomyces naeslundii corrig. Thompson and Lovestedt 1951 (Approved Lists 1980)

  • synonyms

    • @ref: 20215
    • synonym: Actinomyces naeslundi

@ref: 10673

domain: Bacteria

phylum: Actinobacteria

class: Actinobacteria

order: Actinomycetales

family: Actinomycetaceae

genus: Actinomyces

species: Actinomyces naeslundii

full scientific name: Actinomyces naeslundii Thompson and Lovestedt 1951 emend. Henssge et al. 2009 emend. Nouioui et al. 2018

type strain: yes

Morphology

cell morphology

@refmotilityconfidencegram staincell shape
69480no95.189
69480100positive
121221nopositiverod-shaped

colony morphology

  • @ref: 121221
  • hemolysis ability: 1

Culture and growth conditions

culture medium

@refnamegrowthcompositionlink
32933MEDIUM 6 - Columbia agar with 10 % horse bloodyesDistilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
10673BHI/2 MEDIUM (DSMZ Medium 217)yesName: BHI/2 MEDIUM (DSMZ Medium 217) Composition: Brain heart infusion 37.0 g/l Casein hydrolysate 10.0 g/l Glucose 5.0 g/l Yeast extract 5.0 g/l Distilled waterhttps://mediadive.dsmz.de/medium/217
10673COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)yesName: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar basehttps://mediadive.dsmz.de/medium/693
121221CIP Medium 6yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=6

culture temp

@refgrowthtypetemperaturerange
32933positivegrowth37mesophilic
10673positivegrowth37mesophilic
67770positivegrowth37mesophilic
121221positivegrowth30-41
121221nogrowth10psychrophilic
121221nogrowth25mesophilic
121221nogrowth45thermophilic

Physiology and metabolism

oxygen tolerance

@refoxygen tolerance
10673anaerobe
121221facultative anaerobe

spore formation

@refspore formationconfidence
69481no100
69480no99.996

halophily

@refsaltgrowthtested relationconcentration
121221NaClpositivegrowth0-4 %
121221NaClnogrowth6 %
121221NaClnogrowth8 %
121221NaClnogrowth10 %

metabolite utilization

@refmetaboliteutilization activitykind of utilization testedChebi-ID
68371Potassium 5-ketogluconate+builds acid from
68371Potassium 2-ketogluconate-builds acid from
68371gluconate+builds acid from24265
68371L-arabitol-builds acid from18403
68371D-arabitol-builds acid from18333
68371L-fucose+builds acid from18287
68371D-fucose-builds acid from28847
68371D-tagatose-builds acid from16443
68371D-lyxose-builds acid from62318
68371turanose-builds acid from32528
68371gentiobiose-builds acid from28066
68371xylitol-builds acid from17151
68371glycogen-builds acid from28087
68371starch-builds acid from28017
68371raffinose+builds acid from16634
68371melezitose-builds acid from6731
68371inulin-builds acid from15443
68371trehalose+builds acid from27082
68371sucrose+builds acid from17992
68371melibiose+builds acid from28053
68371lactose+builds acid from17716
68371maltose+builds acid from17306
68371cellobiose-builds acid from17057
68371salicin+builds acid from17814
68371esculin+builds acid from4853
68371arbutin+builds acid from18305
68371amygdalin-builds acid from27613
68371N-acetylglucosamine+builds acid from59640
68371methyl alpha-D-glucopyranoside-builds acid from320061
68371methyl alpha-D-mannoside-builds acid from43943
68371D-sorbitol-builds acid from17924
68371D-mannitol-builds acid from16899
68371myo-inositol+builds acid from17268
68371galactitol-builds acid from16813
68371L-rhamnose-builds acid from62345
68371L-sorbose-builds acid from17266
68371D-mannose+builds acid from16024
68371D-fructose+builds acid from15824
68371D-glucose+builds acid from17634
68371D-galactose+builds acid from12936
68371methyl beta-D-xylopyranoside-builds acid from74863
68371ribitol-builds acid from15963
68371L-xylose-builds acid from65328
68371D-xylose-builds acid from65327
68371D-ribose-builds acid from16988
68371L-arabinose-builds acid from30849
68371D-arabinose-builds acid from17108
68371erythritol-builds acid from17113
68371glycerol+builds acid from17754
121221citrate-carbon source16947
121221esculin+hydrolysis4853
121221hippurate-hydrolysis606565
121221nitrate+reduction17632
121221nitrite-reduction16301
121221nitrate+respiration17632
68379nitrate+reduction17632
68379esculin+hydrolysis4853
68379gelatin-hydrolysis5291
68379D-glucose+fermentation17634
68379D-xylose-fermentation65327
68379D-mannitol-fermentation16899
68379maltose+fermentation17306
68379sucrose+fermentation17992
68379glycogen-fermentation28087
68377D-glucose+builds acid from17634
68377D-fructose+builds acid from15824
68377maltose+builds acid from17306
68377sucrose+builds acid from17992
68377ornithine-degradation18257
68377urea+hydrolysis16199
68377tryptophan-energy source27897
68380urea-hydrolysis16199
68380arginine-hydrolysis29016
68380D-mannose+fermentation16024
68380raffinose+fermentation16634
68380L-glutamate-degradation29985
68380nitrate+reduction17632
68380tryptophan-energy source27897

antibiotic resistance

  • @ref: 121221
  • metabolite: 0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)
  • is antibiotic: yes
  • is sensitive: yes
  • is resistant: no

metabolite production

@refChebi-IDmetaboliteproduction
6837735581indoleno
12122135581indoleno
6838035581indoleno

metabolite tests

@refChebi-IDmetaboliteindole testvoges-proskauer-testmethylred-test
6838035581indole-
6837735581indole-
12122115688acetoin-
12122117234glucose+

enzymes

@refvalueactivityec
68382alpha-fucosidase-3.2.1.51
68382alpha-mannosidase-3.2.1.24
68382N-acetyl-beta-glucosaminidase-3.2.1.52
68382beta-glucosidase+3.2.1.21
68382alpha-glucosidase+3.2.1.20
68382beta-glucuronidase-3.2.1.31
68382beta-galactosidase+3.2.1.23
68382alpha-galactosidase+3.2.1.22
68382naphthol-AS-BI-phosphohydrolase-
68382acid phosphatase-3.1.3.2
68382alpha-chymotrypsin-3.4.21.1
68382trypsin-3.4.21.4
68382cystine arylamidase-3.4.11.3
68382valine arylamidase-
68382leucine arylamidase+3.4.11.1
68382lipase (C 14)-
68382esterase lipase (C 8)-
68382esterase (C 4)+
68382alkaline phosphatase-3.1.3.1
68380serine arylamidase-
68380glutamyl-glutamate arylamidase-
68380histidine arylamidase-
68380alanine arylamidase-3.4.11.2
68380tyrosine arylamidase+
68380pyrrolidonyl arylamidase-3.4.19.3
68380leucine arylamidase+3.4.11.1
68380phenylalanine arylamidase+
68380leucyl glycin arylamidase-3.4.11.1
68380proline-arylamidase+3.4.11.5
68380L-arginine arylamidase-
68380alkaline phosphatase-3.1.3.1
68380tryptophan deaminase-4.1.99.1
68380alpha-fucosidase-3.2.1.51
68380glutamate decarboxylase-4.1.1.15
68380N-acetyl-beta-glucosaminidase-3.2.1.52
68380beta-glucuronidase-3.2.1.31
68380alpha-arabinosidase-3.2.1.55
68380beta-glucosidase+3.2.1.21
68380alpha-glucosidase+3.2.1.20
68380beta-Galactosidase 6-phosphate-
68380beta-galactosidase+3.2.1.23
68380alpha-galactosidase+3.2.1.22
68380arginine dihydrolase-3.5.3.6
68380urease-3.5.1.5
68377tryptophan deaminase-4.1.99.1
68377gamma-glutamyltransferase-2.3.2.2
68377proline-arylamidase-3.4.11.5
68377beta-galactosidase+3.2.1.23
68377alkaline phosphatase-3.1.3.1
68377lipase-
68377urease+3.5.1.5
68377ornithine decarboxylase-4.1.1.17
68377beta-lactamase-3.5.2.6
68379catalase-1.11.1.6
68379gelatinase-
68379beta-glucosidase+3.2.1.21
68379N-acetyl-beta-glucosaminidase-3.2.1.52
68379beta-galactosidase+3.2.1.23
68379beta-glucuronidase-3.2.1.31
68379alkaline phosphatase-3.1.3.1
68379pyrrolidonyl arylamidase-3.4.19.3
121221oxidase-
121221beta-galactosidase+3.2.1.23
121221alcohol dehydrogenase-1.1.1.1
121221gelatinase-
121221amylase-
121221DNase-
121221caseinase+3.4.21.50
121221catalase+1.11.1.6
121221tween esterase+/-
121221gamma-glutamyltransferase-2.3.2.2
121221lecithinase-
121221lipase-
121221lysine decarboxylase-4.1.1.18
121221ornithine decarboxylase-4.1.1.17
121221phenylalanine ammonia-lyase-4.3.1.24
121221tryptophan deaminase-
121221urease+3.5.1.5

fatty acid profile

  • fatty acids

    @reffatty acidpercentageECL
    65608C12:0312
    65608C14:02.714
    65608C16:040.416
    65608C18:0718
    65608C18:1 ω9c36.317.769
    65608C18:1 ω9c DMA2.918.226
    65608C18:2 ω6,9c/C18:0 ANTE7.817.724
  • type of FA analysis: whole cell analysis
  • method/protocol: CCUG

API coryne

@refNITPYZPYRAPALbeta GURbeta GALalpha GLUbeta NAGESCUREGELControlRIBXYLMANMALLACSACGLYGCATGLU
65608++---++-++--+--+++--
10673+----+--+------+-+-+
10673++---++/--+------+++--+

API zym

@refControlAlkaline phosphataseEsteraseEsterase LipaseLipaseLeucine arylamidaseValine arylamidaseCystine arylamidaseTrypsinalpha- ChymotrypsinAcid phosphataseNaphthol-AS-BI-phosphohydrolasealpha- Galactosidasebeta- Galactosidasebeta- Glucuronidasealpha- Glucosidasebeta- GlucosidaseN-acetyl-beta- glucosaminidasealpha- Mannosidasealpha- Fucosidase
121221--+--+------++-++---

API 50CHac

@refGLYERYDARALARARIBDXYLLXYLADOMDXGALGLUFRUMNESBERHADULINOMANSORMDMMDGNAGAMYARBESCSALCELMALLACMELSACTREINUMLZRAFAMDGLYGXLTGENTURLYXTAGDFUCLFUCDARLLARLGNT2KG5KG
121221+--------++++---+----+-+++-+++++--+--------+--+-+

API NH

@refPENGLUFRUMALSACODCURELIPPALbeta GALProAGGTIND
65608-++++-+--+---

API rID32A

@refUREADH Argalpha GALbeta GALbeta GPalpha GLUbeta GLUalpha ARAbeta GURbeta NAGMNERAFGDCalpha FUCNITINDPALArgAProALGAPheALeuAPyrATyrAAlaAGlyAHisAGGASerA
10673--++-++---++--+---+-++-+-+/----
10673--++-++---++--+---+-++-+-----
65608--++-++---++--+---+-++-+-----

Isolation, sampling and environmental information

isolation

@refsample type
10673human sinus
67770Human sinus
121221Human, Jaw

isolation source categories

Cat1Cat2Cat3
#Host#Human
#Host Body-Site#Oral cavity and airways
#Host Body-Site#Other#Head

taxonmaps

  • @ref: 69479
  • File name: preview.99_5620.png
  • url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_124;96_361;97_2224;98_2795;99_5620&stattab=map
  • Last taxonomy: Actinomyces naeslundii subclade
  • 16S sequence: NR_113326
  • Sequence Identity:
  • Total samples: 23134
  • soil counts: 345
  • aquatic counts: 595
  • animal counts: 22069
  • plant counts: 125

Safety information

risk assessment

@refpathogenicity humanpathogenicity animalbiosafety levelbiosafety level comment
10673yesyes2Risk group (German classification)
1212212Risk group (French classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
20218Actinomyces naeslundii 16S ribosomal RNA gene, partial sequenceAF058052283ena1655
20218Actinomyces naeslundii partial 16S rRNAX532261376ena1655
10673Actinomyces naeslundii strain CDC W826 16S ribosomal RNA, partial sequenceNR_0370331450nuccore1655
10673Actinomyces naeslundii strain JCM 8349 16S ribosomal RNA, partial sequenceNR_1133261522nuccore1655
67770Actinomyces naeslundii gene for 16S ribosomal RNA, partial cds, strain: JCM 8349AB6187901522ena1655
67770A.naeslundii 16S ribosomal RNAM339111378ena1655
67770A.naeslundii 16S rRNA geneX810621450ena1655

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Actinomyces naeslundii strain NCTC 103011655.49wgspatric1655
66792Actinomyces naeslundii Howell 279, ATCC 121042531839542draftimg1115803
67770Actinomyces naeslundii NCTC 10301GCA_001956585scaffoldncbi1655

GC content

  • @ref: 10673
  • GC-content: 66

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
spore-formingno100no
motileno89.297no
gram-positiveyes94.713no
anaerobicno72.993yes
aerobicno93.092yes
halophileno85.955no
spore-formingno93.855no
thermophileno95.194yes
glucose-utilyes88.666no
flagellatedno96.287no
glucose-fermentyes80.726yes

External links

@ref: 10673

culture collection no.: DSM 43013, ATCC 12104, CCUG 2238, NCTC 10301, CDC W826, JCM 8349, NIH 279, WVU 45, CCUG 18310, CIP 103128

straininfo link

  • @ref: 69836
  • straininfo: 35497

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Metabolism1682868Binding of Actinomyces viscosus to collagen: association with the type 1 fimbrial adhesin.Liu T, Gibbons RJ, Hay DI, Skobe ZOral Microbiol Immunol10.1111/j.1399-302x.1991.tb00443.x1991Actinomyces viscosus/*physiology, *Bacterial Adhesion, Bacterial Proteins/*metabolism, Collagen/*metabolism, Dental Plaque/microbiology, Fimbriae, Bacterial, Humans, Hydroxyapatites, Salivary Proteins and Peptides/metabolismPathogenicity
Genetics1970561Sequence homology between the subunits of two immunologically and functionally distinct types of fimbriae of Actinomyces spp.Yeung MK, Cisar JOJ Bacteriol10.1128/jb.172.5.2462-2468.19901990Actinomyces/*genetics, Amino Acid Sequence, Bacterial Outer Membrane Proteins/*genetics, Base Sequence, Fimbriae Proteins, Fimbriae, Bacterial/immunology/*physiology, *Genes, Bacterial, Macromolecular Substances, Molecular Sequence Data, Protein Conformation, Restriction Mapping, Sequence Homology, Nucleic Acid
Pathogenicity2294047Cellular coaggregation of oral Streptococcus milleri with actinomyces.Eifuku H, Yakushiji T, Mizuno J, Kudo N, Inoue MInfect Immun10.1128/iai.58.1.163-168.19901990Actinomyces/*cytology, Bacterial Adhesion, Carbohydrates/pharmacology, Dental Plaque/*microbiology, Humans, Streptococcus/*cytology
Metabolism2358461Characterization of the binding of Actinomyces naeslundii (ATCC 12104) and Actinomyces viscosus (ATCC 19246) to glycosphingolipids, using a solid-phase overlay approach.Stromberg N, Karlsson KAJ Biol ChemS0021-9258(19)38584-91990Actinomyces/*metabolism, *Antigens, CD, Bacterial Adhesion, Carbohydrate Sequence, Chromatography, Thin Layer, Epithelium/analysis, Erythrocytes/analysis, Fatty Acids, Gangliosides, Glycosphingolipids/*metabolism, Humans, Hydroxylation, Iodine Radioisotopes, *Lactosylceramides, Molecular Sequence Data, Mouth/analysis, Structure-Activity Relationship, Sulfur RadioisotopesPathogenicity
Metabolism2892794Human salivary acidic proline-rich proteins and statherin promote the attachment of Actinomyces viscosus LY7 to apatitic surfaces.Gibbons RJ, Hay DIInfect Immun10.1128/iai.56.2.439-445.19881988Actinomyces/*physiology, Adsorption, *Bacterial Adhesion, Dental Plaque/*microbiology, Fimbriae, Bacterial, Hydroxyapatites, Peptide Fragments/metabolism, Salivary Proteins and Peptides/*physiology
Enzymology2900829Cloning and nucleotide sequence of a gene for Actinomyces naeslundii WVU45 type 2 fimbriae.Yeung MK, Cisar JOJ Bacteriol10.1128/jb.170.9.3803-3809.19881988Actinomyces/*genetics/ultrastructure, Amino Acid Sequence, Bacterial Proteins/*genetics, Base Sequence, Cloning, Molecular, DNA Restriction Enzymes, DNA, Bacterial/*genetics, *Fimbriae, Bacterial, Gene Expression Regulation, Humans, Immunoassay, Molecular Sequence Data, Plasmids, Promoter Regions, Genetic, Protein Sorting Signals/genetics, Repetitive Sequences, Nucleic AcidPathogenicity
Metabolism3804448Binding of Actinomyces naeslundii to glycosphingolipids.Brennan MJ, Joralmon RA, Cisar JO, Sandberg ALInfect Immun10.1128/iai.55.2.487-489.19871987Actinomyces/*metabolism, Chromatography, Thin Layer, Gangliosides/metabolism, Globosides/metabolism, Glycosphingolipids/analysis/*metabolism, Lectins/metabolism
Metabolism4611924Degradation of sucrose by whole cells and plaque of Actinomyces naeslundii.Miller CHInfect Immun10.1128/iai.10.6.1280-1291.19741974Actinomyces/*enzymology/growth & development, Bacteriological Techniques, Carbohydrates/analysis, Chromatography, Thin Layer, Culture Media, Fructose/analysis/biosynthesis, Glucose/metabolism, Hexoses/analysis, Hydrogen-Ion Concentration, Hydrolysis, Kinetics, Polysaccharides/biosynthesis, Sucrose/*metabolism, Temperature, Viral Plaque AssayEnzymology
6150007Exclusive presence of lactose-sensitive fimbriae on a typical strain (WVU45) of Actinomyces naeslundii.Cisar JO, David VA, Curl SH, Vatter AEInfect Immun10.1128/iai.46.2.453-458.19841984Actinomyces/*analysis/immunology, Antigens, Bacterial/analysis, Fimbriae, Bacterial/*analysis/immunology, Lactose
Pathogenicity6150008Lectin-dependent attachment of Actinomyces naeslundii to receptors on epithelial cells.Brennan MJ, Cisar JO, Vatter AE, Sandberg ALInfect Immun10.1128/iai.46.2.459-464.19841984Actinomyces/*physiology, Adhesiveness, Carbohydrate Sequence, Cells, Cultured, Epithelium/microbiology, Fimbriae, Bacterial/*physiology, Humans, Microvilli/microbiology, Receptors, Mitogen/*physiology
Pathogenicity6578231Neuraminidase-activated attachment of Actinomyces naeslundii ATCC 12104 to human buccal epithelial cells.Saunders JM, Miller CHJ Dent Res10.1177/002203458306201005011983Actinomyces/*physiology, Adhesiveness, Epithelial Cells, Galactosides/physiology, Humans, Mouth Mucosa/*cytology/physiology, Neuraminidase/administration & dosage/*pharmacology
Pathogenicity6874075Structural preferences of beta-galactoside-reactive lectins on Actinomyces viscosus T14V and Actinomyces naeslundii WVU45.McIntire FC, Crosby LK, Barlow JJ, Matta KLInfect Immun10.1128/iai.41.2.848-850.19831983Actinomyces/*drug effects, Agglutination/drug effects, Depression, Chemical, Galactosides/*pharmacology, Glycosides/*pharmacology, Lectins/*pharmacology, Streptococcus sanguis/drug effects
Pathogenicity7000708Attachment of Actinomyces naeslundii to human buccal epithelial cells.Saunders JM, Miller CHInfect Immun10.1128/iai.29.3.981-989.19801980Actinomyces/growth & development/*immunology, Binding Sites, Carbohydrates/pharmacology, Cheek/*immunology, Epithelium/immunology, Humans, Hyaluronoglucosaminidase/pharmacology, Lipase/pharmacology, Peptide Hydrolases/pharmacology, Sodium Hydroxide/pharmacology, Temperature, Time Factors, Trypsin/pharmacology
Stress7129635Isolation and characterization of coaggregation-defective mutants of Actinomyces viscosus, Actinomyces naeslundii, and Streptococcus sanguis.Kolenbrander PEInfect Immun10.1128/iai.37.3.1200-1208.19821982Actinomyces/genetics/*physiology, Hot Temperature, Lactose/pharmacology, Lectins/pharmacology, Mutation, Streptococcus sanguis/genetics/*physiology, Surface PropertiesPhylogeny
Enzymology7154407Novel antigens of oral Actinomyces species prepared from a cell wall enzyme lysate.Hamada S, Okahashi N, Kimura S, Imanishi H, Koga T, Kawata S, Michalek SM, McGhee JRJpn J Med Sci Biol10.7883/yoken1952.35.1711982Actinomyces/*immunology, Animals, Antigens, Bacterial/analysis/*isolation & purification, Cell Wall/immunology, Chromatography, Immune Sera/immunology, Muramidase/pharmacology, Rabbits, SolubilityPhylogeny
Pathogenicity7216448Differences in the adsorptive behavior of human strains of Actinomyces viscosus and Actinomyces naeslundii to saliva-treated hydroxyapatite surfaces.Qureshi JV, Gibbons RJInfect Immun10.1128/iai.31.1.261-266.19811981Actinomyces/*physiology, Adsorption, Adult, Amines/pharmacology, Carbohydrates/pharmacology, Child, Humans, *Hydroxyapatites, Neuraminidase/pharmacology, *Saliva, Species SpecificityPhylogeny
Metabolism7478749Surface-associated properties of Actinomyces strains and their potential relation to pathogenesis.Loo CY, Willcox MD, Knox KWOral Microbiol Immunol10.1111/j.1399-302x.1994.tb00208.x1994Actinomyces/metabolism/*pathogenicity/*physiology, Agglutination Tests, Albumins/metabolism, Animals, Bacterial Adhesion/*physiology, Collagen/metabolism, Dental Plaque/microbiology, Durapatite, Fibrinogen/metabolism, Fibronectins/metabolism, Hemagglutination Tests, Humans, Mouth/microbiology, Protein Binding, Pulpitis/microbiology, Rats, Root Caries/microbiology, Saliva/*physiology, Species Specificity, Statistics, Nonparametric, Surface Properties, VirulencePathogenicity
Metabolism7790078Putative glycoprotein and glycolipid polymorphonuclear leukocyte receptors for the Actinomyces naeslundii WVU45 fimbrial lectin.Sandberg AL, Ruhl S, Joralmon RA, Brennan MJ, Sutphin MJ, Cisar JOInfect Immun10.1128/iai.63.7.2625-2631.19951995Actinomyces/*immunology, Bacterial Adhesion, Binding, Competitive, Fimbriae, Bacterial/*metabolism, Gangliosides/*metabolism, Glycolipids/*metabolism, Glycoproteins/*metabolism, Humans, Lectins/*metabolism, Neutrophils/*immunology, Receptors, Cell Surface/*metabolismPathogenicity
Phylogeny8360358Characterization of Actinomyces with genomic DNA fingerprints and rRNA gene probes.Bowden G, Johnson J, Schachtele CJ Dent Res10.1177/002203459307200802011993Actinomyces/*classification/*genetics, Actinomyces viscosus/classification/genetics, Animals, *Bacterial Typing Techniques, Blotting, Southern, Cricetinae, DNA Fingerprinting/methods, DNA Probes, DNA, Bacterial/*analysis/isolation & purification, DNA, Ribosomal/analysis, Dental Caries/microbiology, Dental Plaque/microbiology, Deoxyribonuclease BamHI, Deoxyribonucleases, Type II Site-Specific, Electrophoresis, Agar Gel, Humans, Mouth/microbiology, RNA, Ribosomal/genetics, RatsEnzymology
Metabolism8393654Interactions of Actinomyces naeslundii strains T14V and ATCC 12104 with saliva, collagen and fibrinogen.Hawkins BW, Cannon RD, Jenkinson HFArch Oral Biol10.1016/0003-9969(93)90191-n1993Actinomyces/*physiology, Bacterial Adhesion/*physiology, Bacterial Outer Membrane Proteins/*metabolism, Collagen/metabolism, Durapatite, Fibrinogen/metabolism, Humans, Hydroxyapatites, Saliva/metabolism/microbiologyPathogenicity
Stress8478088Coaggregation of Prevotella intermedia with oral Actinomyces species.Nesbitt WE, Fukushima H, Leung KP, Clark WBInfect Immun10.1128/iai.61.5.2011-2014.19931993Actinomyces/*cytology, *Bacterial Adhesion, Bacteroides/*cytology, Detergents, Dietary Carbohydrates/pharmacology, Endopeptidases/pharmacology, Hot Temperature, Humans, In Vitro Techniques, Mouth/*microbiology, Saliva/microbiologyPathogenicity
Phylogeny8812734Detection of Actinomyces species using nonradioactive riboprobes coupled with polymerase chain reaction.Kiyama M, Hiratsuka K, Saito S, Shiroza T, Takiguchi H, Abiko YBiochem Mol Med10.1006/bmme.1996.00431996Actinomyces/genetics/*isolation & purification, Actinomyces viscosus/genetics, DNA Primers, *DNA Probes, DNA, Bacterial/chemistry, Humans, In Situ Hybridization/methods, Neuraminidase/*genetics, Polymerase Chain Reaction/*methods, RNA/chemistry, Species SpecificityPathogenicity
Pathogenicity8926089Cell surface polypeptide CshA mediates binding of Streptococcus gordonii to other oral bacteria and to immobilized fibronectin.McNab R, Holmes AR, Clarke JM, Tannock GW, Jenkinson HFInfect Immun10.1128/iai.64.10.4204-4210.19961996Animals, Antibody Specificity, *Bacterial Adhesion, Bacterial Proteins/*physiology, Fibronectins/*physiology, Humans, *Membrane Proteins, Mouth/*microbiology, Peptide Fragments/immunology, Rabbits
Genetics9199430Synthesis and function of Actinomyces naeslundii T14V type 1 fimbriae require the expression of additional fimbria-associated genes.Yeung MK, Ragsdale PAInfect Immun10.1128/iai.65.7.2629-2639.19971997Actinomyces viscosus/*genetics, Amino Acid Sequence, Bacterial Proteins/*genetics, Base Sequence, DNA, Bacterial, Fimbriae, Bacterial/*physiology, *Genes, Bacterial, Kanamycin Resistance/genetics, Molecular Sequence Data, Open Reading Frames
Pathogenicity9435058Anaerobic killing of oral streptococci by reduced, transition metal cations.Dunning JC, Ma Y, Marquis REAppl Environ Microbiol10.1128/AEM.64.1.27-33.19981998Actinomyces/drug effects, Adenosine Triphosphatases/drug effects, Anaerobiosis, Cations/*toxicity, Cell Membrane/metabolism, Copper/*toxicity, Enterococcus/drug effects, Escherichia coli/drug effects, *FMN Reductase, Ferricyanides/pharmacology, Ferrocyanides/pharmacology, Ferrous Compounds/*toxicity, Glycolysis/drug effects, Hydrogen Peroxide/metabolism/toxicity, Lactobacillus casei/drug effects, Mouth/microbiology, NADH, NADPH Oxidoreductases/metabolism, Oxygen/metabolism, Streptococcus/*drug effects/enzymology/metabolism, Thiocyanates/pharmacology, Uric Acid/pharmacologyMetabolism
Pathogenicity9916052Genetic and physiologic characterization of urease of Actinomyces naeslundii.Morou-Bermudez E, Burne RAInfect Immun10.1128/IAI.67.2.504-512.19991999Actinomyces/*enzymology/genetics, Base Sequence, Binding Sites, Chromosome Mapping, DNA Primers, DNA, Bacterial, Humans, Molecular Sequence Data, Multigene Family, Sequence Analysis, DNA, Transcription, Genetic, Urease/*genetics/*physiologyGenetics
Metabolism10371247Secretory immunoglobulin A heavy chain presents Galbeta1-3GalNAc binding structures for Actinomyces naeslundii genospecies 1.Bratt P, Boren, Boren T, Str omberg NJ Dent Res10.1177/002203459907800607011999Actinomyces/classification/*metabolism, Antigens, Bacterial/*metabolism, Antigens, Tumor-Associated, Carbohydrate/*metabolism, Bacterial Adhesion, Blotting, Western, Colostrum/immunology, Dental Deposits/metabolism, Dental Pellicle, Humans, Immunoglobulin A, Secretory/*metabolism, Immunoglobulin Heavy Chains/*metabolism, Isoantigens/*metabolism, Lactose/pharmacology, Molecular Weight, Mucins/metabolism, Parotid Gland/immunology, Peanut Agglutinin/metabolism, Protein Binding, Salivary Proteins and Peptides/metabolismPathogenicity
Pathogenicity10716618In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens.Koo H, Gomes BP, Rosalen PL, Ambrosano GM, Park YK, Cury JAArch Oral Biol10.1016/s0003-9969(99)00117-x2000Actinomyces/drug effects, Actinomyces viscosus/drug effects, Analysis of Variance, Anti-Bacterial Agents, Anti-Infective Agents/*therapeutic use, Arnica/*therapeutic use, Bacterial Adhesion/drug effects, Candida albicans/drug effects, Enterococcus faecalis/drug effects, Enzyme Inhibitors/pharmacology, Glucans/antagonists & inhibitors, Glucosyltransferases/antagonists & inhibitors, Humans, Mouth/*microbiology, *Phytotherapy, *Plants, Medicinal, Polysaccharides, Bacterial/drug effects, Porphyromonas/drug effects, Porphyromonas gingivalis/drug effects, Prevotella/drug effects, Propolis/*therapeutic use, Staphylococcus aureus/drug effects, Streptococcus/drug effects, Streptococcus mutans/*drug effects, Streptococcus sanguis/drug effects, Streptococcus sobrinus/drug effects, Sucrose/antagonists & inhibitors
Metabolism10850978Characterization of the fructosyltransferase gene of Actinomyces naeslundii WVU45.Bergeron LJ, Morou-Bermudez E, Burne RAJ Bacteriol10.1128/JB.182.13.3649-3654.20002000Actinomyces/*enzymology/genetics, Amino Acid Sequence, Binding Sites, Chloramphenicol O-Acetyltransferase/metabolism, Chromosome Mapping, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Enzymologic, *Genes, Bacterial, Hexosyltransferases/*genetics/metabolism, Molecular Sequence Data, Promoter Regions, Genetic, Recombinant Fusion Proteins/genetics/metabolism, Sequence Homology, Amino Acid, Transcription, GeneticGenetics
Enzymology11083780Analysis of urease expression in Actinomyces naeslundii WVU45.Morou-Bermudez E, Burne RAInfect Immun10.1128/IAI.68.12.6670-6676.20002000Actinomyces/*enzymology, *Gene Expression Regulation, Enzymologic, Multigene Family, Nitrogen/metabolism, Promoter Regions, Genetic, Transcription, Genetic, Urease/*geneticsMetabolism
Metabolism11500409Roles of fructosyltransferase and levanase-sucrase of Actinomyces naeslundii in fructan and sucrose metabolism.Bergeron LJ, Burne RAInfect Immun10.1128/IAI.69.9.5395-5402.20012001Actinomyces/*enzymology/growth & development, *Bacterial Proteins, Culture Media, Electrophoresis, Polyacrylamide Gel, Fructans/*metabolism, Gene Expression Regulation, Bacterial, Glycoside Hydrolases/genetics/*metabolism, Hexosyltransferases/genetics/*metabolism, Humans, Sucrase/genetics/*metabolism, Sucrose/*metabolismEnzymology
Enzymology12573111Production and characterization of species-specific monoclonal antibodies against Actinomyces naeslundii and Lactobacillus casei.Gu F, Ma X, Lux R, Shi WHybrid Hybridomics10.1089/1536859023210440072002Actinomyces/*immunology/isolation & purification, Adolescent, Antibodies, Monoclonal/*immunology, Antibody Formation/*immunology, Child, Child, Preschool, Dental Caries/immunology, Flow Cytometry, Humans, Lactobacillus casei/*immunology/isolation & purification, Microscopy, Fluorescence, Saliva/microbiologyPhylogeny
Enzymology16412620Characterization of the Actinomyces naeslundii ureolysis and its role in bacterial aciduricity and capacity to modulate pH homeostasis.Liu Y, Hu T, Zhang J, Zhou XMicrobiol Res10.1016/j.micres.2005.11.0022006Actinomyces/enzymology/genetics/*physiology, Gene Expression Regulation, Enzymologic, Homeostasis/*physiology, Hydrogen-Ion Concentration, Transcription, Genetic, Urease/genetics/*physiology
Metabolism18034831Regulation of urease gene of Actinomyces naeslundii in biofilms in response to environmental factors.Liu Y, Hu T, Jiang D, Zhang J, Zhou XFEMS Microbiol Lett10.1111/j.1574-6968.2007.00959.x2007Actinomyces/enzymology/*genetics/growth & development, Bacterial Proteins/*genetics/metabolism, Biofilms/drug effects/*growth & development, Gene Expression Regulation, Bacterial/drug effects, Glucose/pharmacology, Hydrogen-Ion Concentration, Nitrogen/pharmacology, Polymerase Chain Reaction/methods, Urease/*genetics/*metabolismPathogenicity
Pathogenicity18436038Impact of growth conditions on susceptibility of five microbial species to alkaline stress.Brandle N, Zehnder M, Weiger R, Waltimo TJ Endod10.1016/j.joen.2008.02.0272008Actinomyces/drug effects/growth & development, Alkalies/pharmacology, Animals, Bacteria/*drug effects/*growth & development, Bacterial Adhesion/*drug effects, Biofilms/drug effects/growth & development, Calcium Hydroxide/*pharmacology, Candida albicans/drug effects/growth & development, Cattle, Colony Count, Microbial, Culture Media, Dental Disinfectants/pharmacology, Dental Pulp Cavity/microbiology, Dentin, Enterococcus faecalis/drug effects/growth & development, Fusobacterium nucleatum/drug effects/growth & development, Hydrogen-Ion Concentration, Microbial Sensitivity Tests, Root Canal Filling Materials/*pharmacology, Streptococcus sobrinus/drug effects/growth & developmentCultivation
Cultivation18582331Regulation of urease expression of Actinomyces naeslundii in biofilms in response to pH and carbohydrate.Liy Y, Dan J, Tao H, Xuedong ZOral Microbiol Immunol10.1111/j.1399-302X.2008.00430.x2008Actinomyces/*enzymology/physiology, Bacterial Proteins/analysis/genetics, Bacteriological Techniques, *Biofilms, Biomass, Bioreactors, Colony Count, Microbial, Culture Media, Gene Expression Regulation, Enzymologic/genetics, Glucose/analysis/pharmacology, Humans, Hydrogen-Ion Concentration, Microscopy, Confocal, RNA, Messenger/analysis, Reverse Transcriptase Polymerase Chain Reaction, Sucrose/metabolism/*pharmacology, Temperature, Time Factors, Transcription, Genetic/genetics, Up-Regulation, Urease/*analysis/geneticsPathogenicity
Phylogeny19244431Emended description of Actinomyces naeslundii and descriptions of Actinomyces oris sp. nov. and Actinomyces johnsonii sp. nov., previously identified as Actinomyces naeslundii genospecies 1, 2 and WVA 963.Henssge U, Do T, Radford DR, Gilbert SC, Clark D, Beighton DInt J Syst Evol Microbiol10.1099/ijs.0.000950-02009Actinomyces/*classification/genetics/isolation & purification/physiology, Actinomycosis/*microbiology, Animals, Bacterial Proteins/genetics, Bacterial Typing Techniques, Blood/microbiology, Cerebrospinal Fluid/microbiology, DNA, Bacterial/analysis, Humans, Molecular Sequence Data, Mouth/*microbiology, Phenotype, Plague/microbiology, Sequence Analysis, DNA, Species SpecificityPathogenicity
19769270[Initial study on the discrimination of oral common Actinomycetes with metabonomics method].Li MY, Guo Q, Zhou XD, Xiong P, Jia XM, Xiao XR, Li W, Xiao LYHua Xi Kou Qiang Yi Xue Za Zhi2009Actinobacteria, *Actinomyces, Magnetic Resonance Spectroscopy, *Metabolomics
Pathogenicity22077758Effect of saliva viscosity on the co-aggregation between oral streptococci and Actinomyces naeslundii.Kitada K, Oho TGerodontology10.1111/j.1741-2358.2011.00595.x2011Actinomyces/drug effects/*physiology, Adult, Buffers, Glycerol/administration & dosage/pharmacology, Humans, Microbial Interactions/drug effects/physiology, Middle Aged, Phosphates/chemistry, Saliva/microbiology/*physiology, Spectrophotometry, Streptococcus/drug effects/*physiology, Streptococcus anginosus/drug effects/physiology, Streptococcus constellatus/drug effects/physiology, Streptococcus gordonii/drug effects/physiology, Streptococcus intermedius/drug effects/physiology, Streptococcus mitis/drug effects/physiology, Streptococcus mutans/drug effects/physiology, Streptococcus oralis/drug effects/physiology, Streptococcus pneumoniae/drug effects/physiology, Streptococcus sanguis/drug effects/physiology, Viscosity, Young Adult
Pathogenicity22659173Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential.Gong SQ, Niu LN, Kemp LK, Yiu CK, Ryou H, Qi YP, Blizzard JD, Nikonov S, Brackett MG, Messer RL, Wu CD, Mao J, Bryan Brister L, Rueggeberg FA, Arola DD, Pashley DH, Tay FRActa Biomater10.1016/j.actbio.2012.05.0312012Actinomyces/drug effects, Animals, Anti-Infective Agents/*chemistry/pharmacology, Candida albicans/drug effects, Flow Cytometry, Magnetic Resonance Spectroscopy, Methacrylates/*chemistry/pharmacology, Mice, Microscopy, Electron, Transmission, Microscopy, Fluorescence, Quaternary Ammonium Compounds/*chemistry, Silanes/*chemistry, Spectroscopy, Fourier Transform Infrared, Streptococcus mutans/drug effects, Thermogravimetry
Pathogenicity23485857Effect of water-aging on the antimicrobial activities of an ORMOSIL-containing orthodontic acrylic resin.Gong SQ, Epasinghe DJ, Zhou B, Niu LN, Kimmerling KA, Rueggeberg FA, Yiu CK, Mao J, Pashley DH, Tay FRActa Biomater10.1016/j.actbio.2013.02.0312013Acrylic Resins/*chemistry, Anti-Infective Agents/*chemistry/*pharmacology, Bacterial Physiological Phenomena/*drug effects, Cell Survival/drug effects, *Drug Stability, Quaternary Ammonium Compounds/chemistry/*pharmacology, Siloxanes/chemistry, Water/*chemistry
Pathogenicity26056055Removal of Dental Biofilms with an Ultrasonically Activated Water Stream.Howlin RP, Fabbri S, Offin DG, Symonds N, Kiang KS, Knee RJ, Yoganantham DC, Webb JS, Birkin PR, Leighton TG, Stoodley PJ Dent Res10.1177/00220345155892842015*Biofilms, Dental Plaque/microbiology, Humans, Microscopy, Electron, Scanning, Streptococcus mutans/isolation & purification, *Ultrasonics, *WaterEnzymology

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32933Curators of the CIPhttps://brclims.pasteur.fr/brcWeb/souche/detail/1/14892
65608Curators of the CCUGCulture Collection University of Gothenburg (CCUG) (CCUG 2238)https://www.ccug.se/strain?id=2238
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
67770Curators of the JCMhttps://jcm.brc.riken.jp/en/
68371Automatically annotated from API 50CH acid
68377Automatically annotated from API NH
68379Automatically annotated from API Coryne
68380Automatically annotated from API rID32A
68382Automatically annotated from API zym
69479João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.https://microbeatlas.org/MicrobeAtlas 1.0 beta
69480Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesPredictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
69481Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch10.21203/rs.3.rs-2527258/v1Predictions based on the model GenomeNet Sporulation v. 1
69836Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.10.60712/SI-ID35497.1StrainInfo: A central database for resolving microbial strain identifiers
121221Curators of the CIPCollection of Institut Pasteur (CIP 103128)https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20103128