Strain identifier

BacDive ID: 152595

Type strain: No

Species: Staphylococcus aureus

NCBI tax ID(s): 1280 (species)

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For citation purpose refer to the digital object identifier (doi) of the current version.
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General

@ref: 57550

BacDive-ID: 152595

keywords: genome sequence, Bacteria, Gram-positive

description: Staphylococcus aureus CCUG 47167 is a Gram-positive bacterium that was isolated from Human,patient with chronic furunculosis.

NCBI tax id

  • NCBI tax id: 1280
  • Matching level: species

doi: 10.13145/bacdive152595.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacillota
  • domain: Bacteria
  • phylum: Bacillota
  • class: Bacilli
  • order: Caryophanales
  • family: Staphylococcaceae
  • genus: Staphylococcus
  • species: Staphylococcus aureus
  • full scientific name: Staphylococcus aureus Rosenbach 1884 (Approved Lists 1980)

  • synonyms

    • @ref: 20215
    • synonym: Staphylococcus aureus subsp. anaerobius

@ref: 57550

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Caryophanales

family: Staphylococcaceae

genus: Staphylococcus

species: Staphylococcus aureus

type strain: no

Morphology

cell morphology

  • @ref: 69480
  • gram stain: positive
  • confidence: 100

Physiology and metabolism

spore formation

@refspore formationconfidence
69480no99.147
69481no95

metabolite utilization

@refChebi-IDmetaboliteutilization activitykind of utilization tested
6837516199urea-hydrolysis
6837529016arginine+hydrolysis
6837518257ornithine-degradation
683754853esculin-hydrolysis
6837517634D-glucose+fermentation
6837515824D-fructose+fermentation
6837516024D-mannose+fermentation
6837517306maltose+fermentation
6837517716lactose+fermentation
6837527082trehalose+fermentation
6837516899D-mannitol+fermentation
6837516634raffinose-fermentation
6837516988D-ribose-fermentation
6837517057cellobiose-fermentation
6837517632nitrate+reduction
6837517992sucrose+fermentation
6837559640N-acetylglucosamine+fermentation
6837532528turanose+fermentation
6837522599arabinose-fermentation
6837817634D-glucose-builds acid from
6837815824D-fructose+builds acid from
6837816024D-mannose+builds acid from
6837817306maltose+builds acid from
6837817716lactose+builds acid from
6837827082trehalose+builds acid from
6837816899D-mannitol+builds acid from
6837817151xylitol+builds acid from
6837828053melibiose+builds acid from
6837817632nitrate+reduction
6837816634raffinose+builds acid from
6837865327D-xylose-builds acid from
6837817992sucrose-builds acid from
68378320061methyl alpha-D-glucopyranoside+builds acid from
6837859640N-acetylglucosamine-builds acid from
6837829016arginine+hydrolysis
6837816199urea+hydrolysis

antibiotic resistance

@refmetaboliteis antibioticis resistantChEBIis sensitivesensitivity conc.
68378lysostaphinyesyes
68375novobiocinyes28368yes1.8 µg

metabolite production

@refChebi-IDmetaboliteproduction
6837815688acetoinyes
6837515688acetoinyes

metabolite tests

@refChebi-IDmetabolitevoges-proskauer-test
6837815688acetoin+
6837515688acetoin+

enzymes

@refvalueactivityec
68378urease+3.5.1.5
68378arginine dihydrolase+3.5.3.6
68378alkaline phosphatase+3.1.3.1
68375beta-glucuronidase-3.2.1.31
68375pyrrolidonyl arylamidase+3.4.19.3
68375alkaline phosphatase+3.1.3.1
68375L-arginine arylamidase-
68375beta-galactosidase-3.2.1.23
68375beta-glucosidase-3.2.1.21
68375ornithine decarboxylase-4.1.1.17
68375arginine dihydrolase+3.5.3.6
68375urease-3.5.1.5

fatty acid profile

  • fatty acids

    @reffatty acidpercentageECL
    57550C16:02.116
    57550C18:01.818
    57550C14:0 ISO1.113.618
    57550C15:0 ANTEISO63.714.711
    57550C15:0 ISO8.114.621
    57550C16:0 iso115.626
    57550C17:0 anteiso13.216.722
    57550C17:0 iso2.716.629
    57550C18:1 ω9c1.217.769
    57550C18:2 ω6,9c/C18:0 ANTE4.217.724
    57550C19:0 ANTEISO118.729
  • type of FA analysis: whole cell analysis
  • method/protocol: CCUG

API ID32STA

@refUREADH ArgODCESCGLUFRUMNEMALLACTREMANRAFRIBCELNITVPbeta GALArgAPALPyrANOVOSACNAGTURARAbeta GUR
57550-+--+++++++---++--++-+++--

API STA

@refGLUFRUMNEMALLACTREMANXLTMELNITPALVPRAFXYLSACMDGNAGADHURELSTR
57550-++++++++++++--+-+++

Isolation, sampling and environmental information

isolation

  • @ref: 57550
  • sample type: Human,patient with chronic furunculosis

isolation source categories

Cat1Cat2
#Host#Human
#Infection#Disease
#Infection#Patient

Sequence information

Genome sequences

  • @ref: 66792
  • description: Staphylococcus aureus strain V8
  • accession: 1280.34330
  • assembly level: complete
  • database: patric
  • NCBI tax ID: 1280

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
spore-formingno95no
motileno90.439no
gram-positiveyes88.687no
anaerobicno99.481no
aerobicyes89.81no
halophileyes93.738no
spore-formingno92.71no
thermophileno99.708no
glucose-utilyes87.857no
flagellatedno91.367no
glucose-fermentyes85.276yes

External links

@ref: 57550

culture collection no.: CCUG 47167, ATCC 49775

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Pathogenicity7558328Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities.Prevost G, Cribier B, Couppie P, Petiau P, Supersac G, Finck-Barbancon V, Monteil H, Piemont YInfect Immun10.1128/iai.63.10.4121-4129.19951995Amino Acid Sequence, Animals, Bacterial Proteins, Bacterial Toxins/chemistry/*genetics/toxicity, Base Sequence, Cloning, Molecular, Hemolysin Proteins/*genetics, Humans, Leukocidins/chemistry/*genetics/toxicity, Molecular Sequence Data, Rabbits, Sheep, Staphylococcus aureus/*pathogenicity, Transcription, GeneticEnzymology
Pathogenicity9350201Channel-forming leucotoxins from Staphylococcus aureus cause severe inflammatory reactions in a rabbit eye model.Siqueira JA, Speeg-Schatz C, Freitas FI, Sahel J, Monteil H, Prevost GJ Med Microbiol10.1099/00222615-46-6-4861997Acetylglucosaminidase/biosynthesis, Animals, Bacterial Proteins, Bacterial Toxins/*toxicity, Dose-Response Relationship, Drug, Exotoxins/classification/*toxicity, Eye/*drug effects/enzymology/pathology, Hemolysin Proteins/toxicity, Inflammation/*chemically induced, Leukocidins/toxicity, Rabbits, *Staphylococcus aureus, Time FactorsPhylogeny
Genetics9404084Panton-valentine leukocidin genes in a phage-like particle isolated from mitomycin C-treated Staphylococcus aureus V8 (ATCC 49775).Kaneko J, Kimura T, Kawakami Y, Tomita T, Kamio YBiosci Biotechnol Biochem10.1271/bbb.61.19601997Amino Acid Sequence, Bacteriophages/*genetics, Base Sequence, Binding Sites, DNA, Bacterial/genetics/metabolism, *Genes, Bacterial, Leukocidins/*genetics, Mitomycin/*pharmacology, Molecular Sequence Data, Nucleic Acid Synthesis Inhibitors/*pharmacology, Repetitive Sequences, Nucleic Acid, Sequence Homology, Amino Acid, Staphylococcus aureus/*drug effects/*genetics/virologyMetabolism
Pathogenicity9438990Identification of the essential amino acid residues in lukS for the hemolytic activity of staphylococcal leukocidin towards rabbit erythrocytes.Nariya H, Shimatani A, Tomita T, Kamio YBiosci Biotechnol Biochem10.1271/bbb.61.20951997Amino Acid Sequence, Amino Acids, Essential/*analysis, Animals, *Bacterial Proteins, Bacterial Toxins, Base Sequence, Chimera/genetics, Erythrocytes/*drug effects, Escherichia coli/genetics, Exotoxins, *Hemolysis, Humans, Leukocidins/*chemistry/genetics/pharmacology, Molecular Sequence Data, Mutation, Neutrophils/*drug effects, Rabbits, *Staphylococcus aureusGenetics
Genetics9666077Complete nucleotide sequence and molecular characterization of the temperate staphylococcal bacteriophage phiPVL carrying Panton-Valentine leukocidin genes.Kaneko J, Kimura T, Narita S, Tomita T, Kamio YGene10.1016/s0378-1119(98)00278-91998Amino Acid Sequence, Bacterial Toxins, Base Sequence, Binding Sites/genetics, Chromosomes, Bacterial/genetics, Cloning, Molecular, DNA, Single-Stranded/genetics, DNA, Viral/chemistry/*genetics, Exotoxins/genetics, Genes, Viral/*genetics, Genome, Viral, Leukocidins/*genetics, Molecular Sequence Data, Open Reading Frames/genetics, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Staphylococcus Phages/chemistry/*genetics, Staphylococcus aureus/chemistry/genetics/virology, Viral Proteins/chemistry, Viral Structural Proteins/*genetics, Virus Integration/geneticsPathogenicity
Metabolism10966411Variable expressions of Staphylococcus aureus bicomponent leucotoxins semiquantified by competitive reverse transcription-PCR.Bronner S, Stoessel P, Gravet A, Monteil H, Prevost GAppl Environ Microbiol10.1128/AEM.66.9.3931-3938.20002000Bacterial Proteins/genetics/metabolism, Bacterial Toxins/genetics/metabolism, Culture Media, Exotoxins/*genetics/*metabolism, Gene Expression Regulation, Bacterial, *Hemolysin Proteins, Leukocidins/genetics/metabolism, Monomeric GTP-Binding Proteins/genetics/metabolism, RNA, Bacterial/genetics/metabolism, RNA, Messenger/genetics/metabolism, *Reverse Transcriptase Polymerase Chain Reaction, Sensitivity and Specificity, Staphylococcus aureus/genetics/growth & development/*metabolism, *Trans-Activators, Transcription Factors/genetics/metabolismPathogenicity
27994739New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase.Feng J, Paparella AS, Tieu W, Heim D, Clark S, Hayes A, Booker GW, Polyak SW, Abell ADACS Med Chem Lett10.1021/acsmedchemlett.6b002482016
Pathogenicity29131575Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.Paparella AS, Lee KJ, Hayes AJ, Feng J, Feng Z, Cini D, Deshmukh S, Booker GW, Wilce MCJ, Polyak SW, Abell ADACS Infect Dis10.1021/acsinfecdis.7b001342017Anti-Bacterial Agents/chemistry/*pharmacology, Binding Sites, Biotin/metabolism, Dose-Response Relationship, Drug, Enzyme Inhibitors/chemistry/*pharmacology, Halogenation, Humans, Ligases/*antagonists & inhibitors, Microbial Sensitivity Tests, Models, Molecular, Molecular Conformation, Molecular Structure, Protein Binding, Staphylococcus aureus/*drug effects/*enzymologyMetabolism
Enzymology31407891Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.Lee KJ, Tieu W, Blanco-Rodriguez B, Paparella AS, Yu J, Hayes A, Feng J, Marshall AC, Noll B, Milne R, Cini D, Wilce MCJ, Booker GW, Bruning JB, Polyak SW, Abell ADACS Chem Biol10.1021/acschembio.9b004632019Animals, Anti-Bacterial Agents/chemical synthesis/pharmacokinetics/*pharmacology, Bacterial Proteins/*antagonists & inhibitors/chemistry, Carbon-Nitrogen Ligases/*antagonists & inhibitors/chemistry, Crystallography, X-Ray, Drug Design, Drug Stability, Enzyme Inhibitors/chemical synthesis/pharmacokinetics/*pharmacology, Mice, Microbial Sensitivity Tests, Molecular Dynamics Simulation, Rats, Staphylococcus aureus/drug effects/enzymology, Sulfonamides/chemical synthesis/pharmacokinetics/*pharmacologyPathogenicity
Pathogenicity31954568Matrine and baicalin inhibit apoptosis induced by Panton-Valentine leukocidin of Staphylococcus aureus in bovine mammary epithelial cells.Jia F, Ma W, Zhang X, Wang D, Zhou XJ Dairy Sci10.3168/jds.2019-176192020Alkaloids/*pharmacology, Animals, *Apoptosis, Bacterial Toxins/*genetics, Cattle, Epithelial Cells/drug effects, Exotoxins/*genetics, Female, Flavonoids/*pharmacology, Leukocidins/*genetics, Mastitis, Bovine/*microbiology, Mutation, Quinolizines/*pharmacology, Staphylococcal Infections/microbiology/*veterinary, Staphylococcus aureus/*genetics
36399035A New 1,2,3-Triazole Scaffold with Improved Potency against Staphylococcus aureus Biotin Protein Ligase.Stachura DL, Nguyen S, Polyak SW, Jovcevski B, Bruning JB, Abell ADACS Infect Dis10.1021/acsinfecdis.2c004522022*Staphylococcus aureus, *Biotin, Triazoles/pharmacology, Ligases

Reference

@idauthorstitledoi/urlcatalogue
20215Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ10.1099/ijsem.0.004332
57550Curators of the CCUGhttps://www.ccug.se/strain?id=47167Culture Collection University of Gothenburg (CCUG) (CCUG 47167)
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg OvermannAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)https://diaspora-project.de/progress.html#genomes
68375Automatically annotated from API ID32STA
68378Automatically annotated from API STA
69480Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg OvermannPredictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)https://diaspora-project.de/progress.html#genomes
69481Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. MünchPredictions based on the model GenomeNet Sporulation v. 110.21203/rs.3.rs-2527258/v1