Strain identifier

BacDive ID: 147820

Type strain: No

Species: Lacticaseibacillus rhamnosus

NCBI tax ID(s): 47715 (species)

For citation purpose refer to the digital object identifier (doi) of the current version.
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General

@ref: 52036

BacDive-ID: 147820

keywords: genome sequence, Bacteria, aerobe, mesophilic

description: Lacticaseibacillus rhamnosus CCUG 34291 is an aerobe, mesophilic bacterium that was isolated from Human feces.

NCBI tax id

  • NCBI tax id: 47715
  • Matching level: species

doi: 10.13145/bacdive147820.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacillota
  • domain: Bacteria
  • phylum: Bacillota
  • class: Bacilli
  • order: Lactobacillales
  • family: Lactobacillaceae
  • genus: Lacticaseibacillus
  • species: Lacticaseibacillus rhamnosus
  • full scientific name: Lacticaseibacillus rhamnosus (Hansen 1968) Zheng et al. 2020
  • synonyms

    @refsynonym
    20215Lactobacillus casei subsp. rhamnosus
    20215Lactobacillus rhamnosus

@ref: 52036

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Lactobacillales

family: Lactobacillaceae

genus: Lactobacillus

species: Lactobacillus rhamnosus

type strain: no

Morphology

cell morphology

@refmotilityconfidencegram stain
69480no97.167
69480100positive

Culture and growth conditions

culture temp

  • @ref: 52036
  • growth: positive
  • type: growth
  • temperature: 37
  • range: mesophilic

Physiology and metabolism

oxygen tolerance

  • @ref: 52036
  • oxygen tolerance: aerobe

spore formation

@refspore formationconfidence
69480no99.945
69481no100

metabolite utilization

@refmetaboliteutilization activitykind of utilization testedChebi-ID
68371Potassium 5-ketogluconate-builds acid from
68371Potassium 2-ketogluconate-builds acid from
68371gluconate-builds acid from24265
68371L-arabitol-builds acid from18403
68371D-arabitol-builds acid from18333
68371L-fucose+builds acid from18287
68371D-fucose-builds acid from28847
68371D-tagatose+builds acid from16443
68371D-lyxose-builds acid from62318
68371turanose-builds acid from32528
68371gentiobiose+builds acid from28066
68371xylitol-builds acid from17151
68371glycogen-builds acid from28087
68371starch-builds acid from28017
68371raffinose-builds acid from16634
68371melezitose+builds acid from6731
68371inulin-builds acid from15443
68371trehalose+builds acid from27082
68371sucrose-builds acid from17992
68371melibiose-builds acid from28053
68371lactose-builds acid from17716
68371maltose-builds acid from17306
68371cellobiose+builds acid from17057
68371salicin+builds acid from17814
68371esculin+builds acid from4853
68371arbutin+builds acid from18305
68371amygdalin+builds acid from27613
68371N-acetylglucosamine+builds acid from59640
68371methyl alpha-D-glucopyranoside-builds acid from320061
68371methyl alpha-D-mannoside-builds acid from43943
68371D-sorbitol+builds acid from17924
68371D-mannitol+builds acid from16899
68371myo-inositol+builds acid from17268
68371galactitol+builds acid from16813
68371L-rhamnose+builds acid from62345
68371L-sorbose-builds acid from17266
68371D-mannose+builds acid from16024
68371D-fructose+builds acid from15824
68371D-glucose+builds acid from17634
68371D-galactose+builds acid from12936
68371methyl beta-D-xylopyranoside-builds acid from74863
68371ribitol-builds acid from15963
68371L-xylose-builds acid from65328
68371D-xylose-builds acid from65327
68371D-ribose+builds acid from16988
68371L-arabinose-builds acid from30849
68371D-arabinose+builds acid from17108
68371erythritol-builds acid from17113
68371glycerol-builds acid from17754
68381arginine-hydrolysis29016
68381D-ribose-builds acid from16988
68381D-mannitol+builds acid from16899
68381sorbitol-builds acid from30911
68381lactose-builds acid from17716
68381trehalose+builds acid from27082
68381raffinose-builds acid from16634
68381sucrose-builds acid from17992
68381L-arabinose-builds acid from30849
68381D-arabitol-builds acid from18333
68381alpha-cyclodextrin-builds acid from40585
68381hippurate+hydrolysis606565
68381glycogen-builds acid from28087
68381pullulan-builds acid from27941
68381maltose-builds acid from17306
68381melibiose-builds acid from28053
68381melezitose-builds acid from6731
68381methyl beta-D-glucopyranoside-builds acid from320055
68381D-tagatose+builds acid from16443
68381urea-hydrolysis16199

metabolite production

  • @ref: 68381
  • Chebi-ID: 15688
  • metabolite: acetoin
  • production: yes

metabolite tests

  • @ref: 68381
  • Chebi-ID: 15688
  • metabolite: acetoin
  • voges-proskauer-test: +

enzymes

@refvalueactivityec
68381urease-3.5.1.5
68381beta-mannosidase-3.2.1.25
68381glycyl tryptophan arylamidase-
68381N-acetyl-beta-glucosaminidase-3.2.1.52
68381pyrrolidonyl arylamidase+3.4.19.3
68381beta-galactosidase+3.2.1.23
68381Alanyl-Phenylalanyl-Proline arylamidase+
68381alkaline phosphatase-3.1.3.1
68381alpha-galactosidase-3.2.1.22
68381beta-glucuronidase-3.2.1.31
68381beta-glucosidase+3.2.1.21
68381arginine dihydrolase-3.5.3.6

API 50CHac

@refQGLYERYDARALARARIBDXYLLXYLADOMDXGALGLUFRUMNESBERHADULINOMANSORMDMMDGNAGAMYARBESCSALCELMALLACMELSACTREINUMLZRAFAMDGLYGXLTGENTURLYXTAGDFUCLFUCDARLLARLGNT2KG5KG
52036---+-+----++++-+++++--++++++----+-+----+--+-+-----

API rID32STR

@refADH Argbeta GLUbeta GARbeta GURalpha GALPALRIBMANSORLACTRERAFSACLARADARLCDEXVPAPPAbeta GALPyrAbeta NAGGTAHIPGLYGPULMALMELMLZMbeta DGTAGbeta MANURE
52036-++----+--+-----++++--+------+--

Isolation, sampling and environmental information

isolation

  • @ref: 52036
  • sample type: Human feces

isolation source categories

Cat1Cat2Cat3
#Host#Human
#Host Body Product#Gastrointestinal tract#Feces (Stool)

Sequence information

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Lacticaseibacillus rhamnosus GG GG (ATCC 53103)GCA_000026505completencbi568703
66792Lacticaseibacillus rhamnosus GG ATCC 53103GCA_000011045completencbi568703
66792Lactobacillus rhamnosus GG ATCC 53103568703.30completepatric568703

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
spore-formingno100no
motileno93.874no
flagellatedno97.66no
gram-positiveyes93.955no
anaerobicno94.765no
aerobicno94.303yes
halophileyes80.377no
spore-formingno90.694no
glucose-utilyes92.014no
thermophileno97.61yes
glucose-fermentyes89.102no

External links

@ref: 52036

culture collection no.: CCUG 34291, ATCC 53103, LMG 18243

straininfo link

  • @ref: 102489
  • straininfo: 8915

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Metabolism7552958Effect of Lactobacillus rhamnosus strain GG (ATCC 53103) on the growth of Streptococcus sobrinus in vitro.Meurman JH, Antila H, Korhonen A, Salminen SEur J Oral Sci10.1111/j.1600-0722.1995.tb00169.x1995*Antibiosis, Ecology, Enterococcus faecalis/growth & development/metabolism/ultrastructure, Fermentation, Humans, Hydrogen-Ion Concentration, Lactobacillus/chemistry/classification/metabolism/*physiology, Lactobacillus casei/chemistry/classification/metabolism/physiology, Mouth/microbiology, Streptococcus sanguis/growth & development/metabolism/ultrastructure, Streptococcus sobrinus/*growth & development/metabolism/ultrastructure, Sucrose/metabolismPathogenicity
Pathogenicity9172443Recovery of Lactobacillus rhamnosus GG from human colonic biopsies.Alander M, Korpela R, Saxelin M, Vilpponen-Salmela T, Mattila-Sandholm T, von Wright ALett Appl Microbiol10.1046/j.1472-765x.1997.00140.x1997Adult, Aged, Animals, Bacterial Adhesion, Colon/*microbiology, Colonoscopy, Ecosystem, Feces/microbiology, Female, Humans, Lactobacillus/growth & development/*isolation & purification, Male, Middle Aged, Milk/microbiologyEnzymology
Pathogenicity9237125Lactobacillus rhamnosus GG (ATCC 53103) and platelet aggregation in vitro.Korpela R, Moilanen E, Saxelin M, Vapaatalo HInt J Food Microbiol10.1016/s0168-1605(97)00049-41997Adult, Humans, Lactobacillus/*pathogenicity, Middle Aged, *Platelet Aggregation
Phylogeny9706787Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes.Tynkkynen S, Singh KV, Varmanen PInt J Food Microbiol10.1016/s0168-1605(98)00051-81998Anti-Bacterial Agents/pharmacology, Conjugation, Genetic, DNA, Bacterial/genetics, Drug Resistance, Microbial/genetics, Enterococcus faecalis/*genetics, Enterococcus faecium/*genetics, Genes, Bacterial/*genetics, Lactobacillus/*genetics, Nucleic Acid Hybridization/methods, Polymerase Chain Reaction/methods, Vancomycin/pharmacology
Pathogenicity11122221Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG.Pessi T, Sutas Y, Hurme M, Isolauri EClin Exp Allergy10.1046/j.1365-2222.2000.00948.x2000Animals, Child, Preschool, Dermatitis, Atopic/blood/etiology/*therapy, Edible Grain/adverse effects, Eggs/adverse effects, Feces/chemistry, Food Hypersensitivity/blood/etiology/*therapy, Humans, Immunoglobulin A/analysis, Infant, Interleukin-10/analysis/*biosynthesis/blood, *Lactobacillus, Leukocytes, Mononuclear/immunology, Milk/adverse effects, Probiotics/*therapeutic use, Tumor Necrosis Factor-alpha/analysis
Pathogenicity11360922Suppression of T-cell activation by Lactobacillus rhamnosus GG-degraded bovine casein.Pessi T, Isolauri E, Sutas Y, Kankaanranta H, Moilanen E, Hurme MInt Immunopharmacol10.1016/s1567-5769(00)00018-72001Animals, Calcium/metabolism, Caseins/metabolism/*pharmacology, Cattle, Humans, Immunosuppressive Agents/*pharmacology, Interferon-gamma/biosynthesis, Interleukin-2/biosynthesis/genetics, Interleukin-4/biosynthesis, Lactobacillus/*physiology, Lymphocyte Activation/*drug effects, Protein Kinase C/physiology, RNA, Messenger/analysis, T-Lymphocytes/*drug effects/immunologyMetabolism
Pathogenicity11375147Characterization of the properties of human- and dairy-derived probiotics for prevention of infectious diseases in fish.Nikoskelainen S, Salminen S, Bylund G, Ouwehand ACAppl Environ Microbiol10.1128/AEM.67.6.2430-2435.20012001Aeromonas/drug effects, Animals, Bacterial Adhesion, Bifidobacterium, Dairying/methods, Enterococcus faecium, Fish Diseases/*prevention & control, Flavobacterium/drug effects, Gram-Negative Bacterial Infections/prevention & control/*veterinary, *Gram-Positive Bacteria, Humans, *Lactic Acid, Lactobacillus, Probiotics/pharmacology/*therapeutic use, Vibrio/drug effects
Metabolism11425726Surface binding of aflatoxin B(1) by lactic acid bacteria.Haskard CA, El-Nezami HS, Kankaanpaa PE, Salminen S, Ahokas JTAppl Environ Microbiol10.1128/AEM.67.7.3086-3091.20012001Aflatoxin B1/*metabolism, Culture Media, Enzyme-Linked Immunosorbent Assay, Hot Temperature, Hydrogen-Ion Concentration, Lactobacillus/growth & development/*metabolism, Lactococcus/classification/growth & development/*metabolism, Protein BindingCultivation
Pathogenicity11906339No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study.Helin T, Haahtela S, Haahtela TAllergy10.1034/j.1398-9995.2002.1s3299.x2002Administration, Oral, Adolescent, Adult, Betula/*immunology, Double-Blind Method, Female, Humans, Hypersensitivity/*therapy, *Lactobacillus, Male, Pollen/*immunology, Probiotics/*therapeutic use
Genetics12099838Structural studies of the exopolysaccharide produced by Lactobacillus rhamnosus strain GG (ATCC 53103).Landersjo C, Yang Z, Huttunen E, Widmalm GBiomacromolecules10.1021/bm020040q2002Carbohydrate Conformation, Carbohydrate Sequence, Lactobacillus/*chemistry, Molecular Sequence Data, Nuclear Magnetic Resonance, Biomolecular, Polysaccharides, Bacterial/*chemistry
Pathogenicity12446187Short-term consumption of probiotic-containing cheese and its effect on dental caries risk factors.Ahola AJ, Yli-Knuuttila H, Suomalainen T, Poussa T, Ahlstrom A, Meurman JH, Korpela RArch Oral Biol10.1016/s0003-9969(02)00112-72002Adolescent, Adult, Cheese/*microbiology, Dental Caries/prevention & control, *Dental Caries Susceptibility, Double-Blind Method, Female, Humans, *Lactobacillus, Logistic Models, Male, Probiotics/*therapeutic use, Risk Factors, Saliva/metabolism/microbiology, Streptococcus mutans/isolation & purification, Yeasts/isolation & purificationEnzymology
Pathogenicity12788576Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial.Kalliomaki M, Salminen S, Poussa T, Arvilommi H, Isolauri ELancet10.1016/S0140-6736(03)13490-32003Child, Preschool, Dermatitis, Atopic/diagnosis/*prevention & control, Follow-Up Studies, Humans, Infant, Infant, Newborn, *Lactobacillus, Probiotics/*therapeutic use, Randomized Controlled Trials as Topic, Skin Tests, Surveys and Questionnaires
14550670Immune enhancement in rainbow trout (Oncorhynchus mykiss) by potential probiotic bacteria (Lactobacillus rhamnosus).Nikoskelainen S, Ouwehand AC, Bylund G, Salminen S, Lilius EMFish Shellfish Immunol10.1016/s1050-4648(03)00023-82003Analysis of Variance, Animal Feed, Animals, Dietary Supplements/*microbiology, Escherichia coli/pathogenicity, Immunoglobulins/blood, Lactobacillus/immunology/*physiology, Luminescent Measurements, Oncorhynchus mykiss/*immunology/*microbiology, *Probiotics
Phylogeny16709533Probiotic lactobacilli and bacteraemia in Stockholm.Sullivan A, Nord CEScand J Infect Dis10.1080/003655405004498262006Anti-Bacterial Agents/*therapeutic use, Bacteremia/drug therapy/epidemiology/*microbiology, Colony Count, Microbial, Gram-Positive Bacterial Infections/drug therapy/epidemiology/*microbiology, Humans, Immunocompromised Host, Lactobacillus/classification/*isolation & purification/pathogenicity, Lactobacillus acidophilus/classification/isolation & purification/pathogenicity, Lactobacillus rhamnosus/classification/isolation & purification/pathogenicity, Microbial Sensitivity Tests, *Probiotics/adverse effects, Sweden/epidemiologyPathogenicity
Phylogeny16877985Probiotic intervention in the first months of life: short-term effects on gastrointestinal symptoms and long-term effects on gut microbiota.Rinne M, Kalliomaki M, Salminen S, Isolauri EJ Pediatr Gastroenterol Nutr10.1097/01.mpg.0000228106.91240.5b2006Adult, Bifidobacterium/growth & development/isolation & purification, Clostridium/growth & development/isolation & purification, Colony Count, Microbial, Crying, Diarrhea, Infantile/epidemiology/microbiology, Enterococcus/growth & development/isolation & purification, Feces/*microbiology, Female, Humans, In Situ Hybridization, Fluorescence, Infant, *Infant Nutritional Physiological Phenomena, Infant, Newborn, Lactobacillus rhamnosus/*growth & development/isolation & purification, Male, Pregnancy, Prenatal Care/*methods, *Probiotics, Species Specificity, Vomiting/epidemiologyEnzymology
Pathogenicity17077076Intestinal colonisation, microbiota and future probiotics?Salminen S, Benno Y, de Vos WAsia Pac J Clin Nutr2006Bifidobacterium/growth & development/*physiology, Humans, Intestinal Diseases/*prevention & control, Intestines/*microbiology, Lactobacillus/growth & development/*physiology, *Probiotics/administration & dosage/therapeutic use
Metabolism17292991Growth of probiotic bacteria and bifidobacteria in a soy yogurt formulation.Farnworth ER, Mainville I, Desjardins MP, Gardner N, Fliss I, Champagne CInt J Food Microbiol10.1016/j.ijfoodmicro.2006.12.0152007Animals, Bifidobacterium/*growth & development/metabolism, Cattle, Chromatography, High Pressure Liquid, Colony Count, Microbial, Fermentation, Food Microbiology, Humans, Hydrogen-Ion Concentration, Lactobacillus/*growth & development/metabolism, Milk/microbiology, *Probiotics, Soy Foods/*microbiology, Yogurt/*microbiologyBiotechnology
Metabolism17434999Functional analysis of D-alanylation of lipoteichoic acid in the probiotic strain Lactobacillus rhamnosus GG.Perea Velez M, Verhoeven TL, Draing C, Von Aulock S, Pfitzenmaier M, Geyer A, Lambrichts I, Grangette C, Pot B, Vanderleyden J, De Keersmaecker SCAppl Environ Microbiol10.1128/AEM.02083-062007Alanine/*metabolism, Anti-Bacterial Agents/pharmacology, Bacterial Adhesion/genetics, Bacterial Proteins/genetics, Bacteriolysis/genetics, Biofilms/growth & development, Cell Line, Cell Wall/chemistry/metabolism, Cytokines/immunology, DNA, Bacterial/chemistry/genetics, Epithelial Cells/immunology/microbiology, Gastric Juice/microbiology, Gene Deletion, Humans, Lactobacillus rhamnosus/drug effects/genetics/immunology/*metabolism, Lipopolysaccharides/chemistry/*metabolism, Magnetic Resonance Spectroscopy, Microbial Viability/genetics, Microscopy, Electron, Transmission, Molecular Sequence Data, Mutagenesis, Insertional, Nisin/pharmacology, Polymyxin B/pharmacology, Probiotics/chemistry/*metabolism, Sequence Analysis, DNA, Teichoic Acids/chemistry/*metabolism, Thiolester Hydrolases/genetics, beta-Defensins/immunologyPathogenicity
Metabolism17827316Impact of environmental and genetic factors on biofilm formation by the probiotic strain Lactobacillus rhamnosus GG.Lebeer S, Verhoeven TL, Perea Velez M, Vanderleyden J, De Keersmaecker SCAppl Environ Microbiol10.1128/AEM.01393-072007Bacterial Adhesion/*physiology, Bacterial Proteins/metabolism, Biofilms/*growth & development, Carbon-Sulfur Lyases/metabolism, Gene Expression Regulation, Bacterial, Genes, Bacterial, Lactobacillus rhamnosus/*genetics/physiology, Lipopolysaccharides/metabolism, Polysaccharides, Bacterial/metabolism, Probiotics, Teichoic Acids/metabolism
Phylogeny18326671Taxonomic and strain-specific identification of the probiotic strain Lactobacillus rhamnosus 35 within the Lactobacillus casei group.Coudeyras S, Marchandin H, Fajon C, Forestier CAppl Environ Microbiol10.1128/AEM.02286-072008Base Sequence, DNA Fingerprinting, DNA Primers/genetics, DNA, Bacterial/chemistry/*genetics, Electrophoresis, Gel, Pulsed-Field, Electrophoresis, Polyacrylamide Gel, Genes, rRNA, Hot Temperature, Lactobacillus rhamnosus/*classification/*genetics, Molecular Sequence Data, Nucleic Acid Denaturation, Nucleic Acid Hybridization, Phylogeny, Polymerase Chain Reaction/methods, *Probiotics, Ribotyping, Sensitivity and Specificity, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Nucleic AcidEnzymology
Enzymology19465252Comparison of inactivation pathways of thermal or high pressure inactivated Lactobacillus rhamnosus ATCC 53103 by flow cytometry analysis.Ananta E, Knorr DFood Microbiol10.1016/j.fm.2009.01.0082009Cell Separation, Colony Count, Microbial, *Flow Cytometry, Fluoresceins/pharmacokinetics, Fluorescent Dyes/*pharmacokinetics, Food Microbiology, Food Preservation/*methods, *Hot Temperature, *Hydrostatic Pressure, Kinetics, Lactobacillus rhamnosus/*growth & development, Probiotics, Propidium/pharmacokineticsBiotechnology
Genetics19820099Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103.Morita H, Toh H, Oshima K, Murakami M, Taylor TD, Igimi S, Hattori MJ Bacteriol10.1128/JB.01287-092009DNA, Bacterial/chemistry/*genetics, Gastrointestinal Tract/microbiology, *Genome, Bacterial, Humans, Lactobacillus rhamnosus/*genetics/isolation & purification, Molecular Sequence Data, Probiotics, *Sequence Analysis, DNAPathogenicity
Pathogenicity20231842The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years.Luoto R, Kalliomaki M, Laitinen K, Isolauri EInt J Obes (Lond)10.1038/ijo.2010.502010Age Factors, Birth Weight, Child, Preschool, Double-Blind Method, Female, Fetal Development, Finland/epidemiology, Follow-Up Studies, Humans, Infant, Infant, Newborn, *Lactobacillus rhamnosus, Male, Maternal Nutritional Physiological Phenomena, Obesity/epidemiology/physiopathology/*prevention & control, Pregnancy, Prenatal Care, Probiotics/*therapeutic use, Weight Gain/physiology
Metabolism20388096Lactobacillus rhamnosus GG influences polyamine metabolism in HGC-27 gastric cancer cell line: a strategy toward nutritional approach to chemoprevention of gastric cance.Linsalata M, Cavallini A, Messa C, Orlando A, Refolo MG, Russo FCurr Pharm Des10.2174/1381612107908835982010Acetyltransferases/genetics/metabolism, Cell Line, Tumor, Cell Proliferation/*drug effects, Humans, Lactobacillus rhamnosus/*physiology, Ornithine Decarboxylase/genetics/metabolism, Polyamines/*metabolism, Probiotics/*pharmacology, RNA, Messenger/genetics/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Stomach Neoplasms/*metabolism/microbiology/*prevention & controlPathogenicity
Cultivation20600855Evaluation of antimicrobial activity of probiotic bacteria against Salmonella enterica subsp. enterica serovar typhimurium 1344 in a common medium under different environmental conditions.Marianelli C, Cifani N, Pasquali PRes Microbiol10.1016/j.resmic.2010.06.0072010Anaerobiosis, *Antibiosis, Bacillus/*physiology, Bacteriocins/metabolism, Culture Media, Hydrogen-Ion Concentration, Intestinal Mucosa/microbiology, Intestine, Small/microbiology, Lactobacillus reuteri/*physiology, Lactobacillus rhamnosus/*physiology, Oxidative Stress, *Probiotics, Salmonella typhimurium/*growth & developmentMetabolism
Pathogenicity20970896Impact of dietary counselling and probiotic intervention on maternal anthropometric measurements during and after pregnancy: a randomized placebo-controlled trial.Ilmonen J, Isolauri E, Poussa T, Laitinen KClin Nutr10.1016/j.clnu.2010.09.0092011Adiposity, Adult, Analysis of Variance, *Anthropometry, Bifidobacterium, Breast Feeding, *Counseling, *Diet, *Dietary Supplements, Double-Blind Method, Feeding Behavior, Female, Follow-Up Studies, Humans, Lactobacillus, Logistic Models, *Maternal Nutritional Physiological Phenomena, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Probiotics/*administration & dosage, Single-Blind Method
Enzymology21059281Manufacturing process influences properties of probiotic bacteria.Grzeskowiak L, Isolauri E, Salminen S, Gueimonde MBr J Nutr10.1017/S00071145100044962010*Bacterial Adhesion, Colon/*microbiology, DNA, Bacterial/analysis, Electrophoresis, Gel, Pulsed-Field, Humans, Hydrogen-Ion Concentration, Industry, Intestinal Mucosa/*microbiology, Lactobacillus rhamnosus/genetics/isolation & purification/*physiology, *Microbial Interactions, Probiotics/*analysis, Random Amplified Polymorphic DNA Technique, Species SpecificityPhylogeny
Pathogenicity21121981Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis.Nermes M, Kantele JM, Atosuo TJ, Salminen S, Isolauri EClin Exp Allergy10.1111/j.1365-2222.2010.03657.x2010Administration, Oral, B-Lymphocyte Subsets/immunology, Cell Separation, Dermatitis, Atopic/*immunology, Double-Blind Method, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunity, Humoral/drug effects/immunology, Infant, Infant Formula/chemistry, Intestinal Mucosa/drug effects/*microbiology, Lactobacillus rhamnosus/*immunology, Polymerase Chain Reaction, Probiotics/*administration & dosage, Skin/drug effects/*microbiology
Pathogenicity21803698In vitro selection of antibiotic resistance in the probiotic strain Lactobacillus rhamnosus GG ATCC 53103.Drago L, Rodighiero V, Mattina R, Toscano M, DE Vecchi EJ Chemother10.1179/joc.2011.23.4.2112011Anti-Bacterial Agents/pharmacology, Dairy Products/microbiology, Drug Resistance, Microbial, Fluoroquinolones/pharmacology, Lactobacillus rhamnosus/*drug effects/genetics, Macrolides/pharmacology, Microbial Sensitivity Tests/methods, Mutation, *Probiotics
Biotechnology21819671Characterization of certain bacterial strains for potential use as starter or probiotic cultures in dairy products.Monteagudo-Mera A, Caro I, Rodriguez-Aparicio LB, Rua J, Ferrero MA, Garcia-Armesto MRJ Food Prot10.4315/0362-028X.JFP-10-3922011Animals, Cattle, Colony Count, Microbial, Dairy Products/*microbiology, Enterococcus faecalis/physiology, Fermentation, *Food Microbiology, Humans, Lactobacillus/physiology, Lactococcus/physiology, Leuconostoc/physiology, Milk/microbiology, *Probiotics, Sheep, Species SpecificityPathogenicity
22099374Stability of lactobacilli encapsulated in various microbial polymers.Jimenez-Pranteda ML, Poncelet D, Nader-Macias ME, Arcos A, Aguilera M, Monteoliva-Sanchez M, Ramos-Cormenzana AJ Biosci Bioeng10.1016/j.jbiosc.2011.10.0102011Bile/physiology, Biopolymers/chemistry, Capsules, Gastrointestinal Tract/physiology, Hydrogen-Ion Concentration, *Lactobacillus, Lactobacillus plantarum, Lactobacillus rhamnosus, Polysaccharides, Bacterial/*chemistry, Probiotics/*administration & dosage
Genetics22328760Whole-genome shotgun sequencing of Lactobacillus rhamnosus MTCC 5462, a strain with probiotic potential.Prajapati JB, Khedkar CD, Chitra J, Suja S, Mishra V, Sreeja V, Patel RK, Ahir VB, Bhatt VD, Sajnani MR, Jakhesara SJ, Koringa PG, Joshi CGJ Bacteriol10.1128/JB.06644-112012Cholesterol/metabolism, DNA, Bacterial/*chemistry/*genetics, Gastrointestinal Tract/*microbiology, *Genome, Bacterial, Humans, Immunologic Factors/pharmacology, Infant, Lactobacillus rhamnosus/*genetics/immunology/*isolation & purification/physiology, Molecular Sequence Data, *Probiotics, Sequence Analysis, DNAPathogenicity
22440280Dietary addition of Lactobacillus rhamnosus GG impairs the health of Escherichia coli F4-challenged piglets.Trevisi P, Casini L, Coloretti F, Mazzoni M, Merialdi G, Bosi PAnimal10.1017/S17517311110004622011
Metabolism22612915Characterization of a Panela cheese with added probiotics and fava bean starch.Escobar MC, Van Tassell ML, Martinez-Bustos F, Singh M, Castano-Tostado E, Amaya-Llano SL, Miller MJJ Dairy Sci10.3168/jds.2011-46552012Bifidobacterium/metabolism, *Cheese/standards, Food Microbiology/*methods, Food Technology/methods, Hydrolysis, Lactobacillus/metabolism, Probiotics/*metabolism, *Starch/metabolism, *Vicia faba/metabolismBiotechnology
Pathogenicity22816209Effect of LGG yoghurt on Streptococcus mutans and Lactobacillus spp. salivary counts in children.Glavina D, Gorseta K, Skrinjaric I, Vranic DN, Mehulic K, Kozul KColl Antropol2012Child, Dental Caries/microbiology/*prevention & control, Dental Plaque/microbiology/prevention & control, Female, Humans, Lactobacillus rhamnosus/*growth & development, Male, Probiotics/*administration & dosage, Saliva/*microbiology, Streptococcus mutans/*growth & development, Yogurt/*microbiology
Enzymology22955366Comparison of the kinetics of intestinal colonization by associating 5 probiotic bacteria assumed either in a microencapsulated or in a traditional, uncoated form.Piano MD, Carmagnola S, Ballare M, Balzarini M, Montino F, Pagliarulo M, Anderloni A, Orsello M, Tari R, Sforza F, Mogna L, Mogna GJ Clin Gastroenterol10.1097/MCG.0b013e31826727962012Adult, Bifidobacterium/classification/*growth & development, Capsules/*administration & dosage, Colony Count, Microbial, Cross-Over Studies, Double-Blind Method, Feces/microbiology, Female, Gastrointestinal Transit, Humans, Intestines/*microbiology, Kinetics, Lactobacillus/classification/*growth & development, Lactobacillus acidophilus/growth & development, Lactobacillus rhamnosus/growth & development, Male, Middle Aged, Probiotics/*administration & dosagePhylogeny
Genetics23003331Evaluation of strain-specific primers for identification of Lactobacillus rhamnosus GG.Endo A, Aakko J, Salminen SFEMS Microbiol Lett10.1111/1574-6968.120152012Bacteriological Techniques/*methods, Bacteriophages/genetics, DNA Fingerprinting, DNA Primers/*genetics, DNA, Bacterial/chemistry/*genetics, Genotype, Lactobacillus rhamnosus/*classification/*genetics/isolation & purification, Molecular Sequence Data, Polymerase Chain Reaction/*methods, Sequence Analysis, DNAPhylogeny
Metabolism23332852Antimicrobial potential for the combination of bovine lactoferrin or its hydrolysate with lactoferrin-resistant probiotics against foodborne pathogens.Chen PW, Jheng TT, Shyu CL, Mao FCJ Dairy Sci10.3168/jds.2012-61122013Animals, Anti-Infective Agents/administration & dosage/*therapeutic use, Bifidobacterium/metabolism, Cattle, Enterococcus faecalis/drug effects, Escherichia coli/drug effects, Lactobacillus/metabolism, Lactobacillus acidophilus/metabolism, Lactobacillus rhamnosus/metabolism, Lactoferrin/administration & dosage/drug effects/*therapeutic use, Pediococcus/metabolism, Probiotics/administration & dosage/*therapeutic use, Protein Hydrolysates, Salmonella typhimurium/drug effectsPathogenicity
23354703Genome instability in Lactobacillus rhamnosus GG.Sybesma W, Molenaar D, van IJcken W, Venema K, Kort RAppl Environ Microbiol10.1128/AEM.03566-122013DNA Transposable Elements, DNA, Bacterial/genetics, *Genomic Instability, Lactobacillus rhamnosus/*genetics, Polymerase Chain Reaction, Probiotics, Sequence Deletion
Pathogenicity23886977The development of probiotic treatment in obesity: a review.Mekkes MC, Weenen TC, Brummer RJ, Claassen EBenef Microbes10.3920/BM2012.00692014Adipose Tissue/microbiology, Adiposity, Bifidobacterium/metabolism, Body Weight, Fatty Acids, Volatile/*biosynthesis, Gastrointestinal Tract/*microbiology, Humans, Inflammation/immunology/*microbiology, Lactobacillus/metabolism, Microbiota, Obesity/*therapy, Probiotics/*therapeutic use, Weight LossMetabolism
Pathogenicity24118564Lactobacillus rhamnosus protects human colonic muscle from pathogen lipopolysaccharide-induced damage.Ammoscato F, Scirocco A, Altomare A, Matarrese P, Petitta C, Ascione B, Caronna R, Guarino M, Marignani M, Cicala M, Chirletti P, Malorni W, Severi CNeurogastroenterol Motil10.1111/nmo.122322013Cells, Cultured, Colon/drug effects/*microbiology, Gastrointestinal Motility, Humans, *Lactobacillus rhamnosus, Lipopolysaccharides/*toxicity, Muscle, Smooth/drug effects/*microbiology, Probiotics/*pharmacology
Pathogenicity24131826Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: a randomized, placebo-controlled trial.Luoto R, Ruuskanen O, Waris M, Kalliomaki M, Salminen S, Isolauri EJ Allergy Clin Immunol10.1016/j.jaci.2013.08.0202013DNA, Viral/analysis, Double-Blind Method, Female, Humans, Infant, Infant, Newborn, Infant, Premature, Male, Picornaviridae Infections/*prevention & control/virology, *Prebiotics, Probiotics/*therapeutic use, Respiratory Tract Diseases/*prevention & control/virology, Rhinovirus/*physiology, Viral Load
24281668Removal of cholera toxin from aqueous solution by probiotic bacteria.Heikkila JE, Nybom SM, Salminen SJ, Meriluoto JAPharmaceuticals (Basel)10.3390/ph50606652012
Pathogenicity24501384Immune response and intestinal permeability in children with acute gastroenteritis treated with Lactobacillus rhamnosus GG: a randomized, double-blind, placebo-controlled trial.Sindhu KN, Sowmyanarayanan TV, Paul A, Babji S, Ajjampur SS, Priyadarshini S, Sarkar R, Balasubramanian KA, Wanke CA, Ward HD, Kang GClin Infect Dis10.1093/cid/ciu0652014Antibodies, Protozoan/blood, Antibodies, Viral/blood, Child, Preschool, Cryptosporidiosis/*therapy, Double-Blind Method, Female, Gastroenteritis/*therapy, Gastrointestinal Tract/*physiology, Humans, Immunoglobulin A/blood, Immunoglobulin G/blood, India, Infant, Lactobacillus rhamnosus/*growth & development, Lactulose/analysis, Male, Mannitol/analysis, *Permeability, Placebos/administration & dosage, Probiotics/*administration & dosage, Rotavirus Infections/*therapy, Treatment Outcome, Urine/chemistry
Metabolism24632842Comparative genome analysis of Lactobacillus rhamnosus clinical isolates from initial stages of dental pulp infection: identification of a new exopolysaccharide cluster.Nadkarni MA, Chen Z, Wilkins MR, Hunter NPLoS One10.1371/journal.pone.00906432014Bacterial Adhesion/genetics/physiology, Bacterial Proteins/genetics/metabolism, Dental Pulp/*microbiology, Genomics/*methods, Humans, Lactobacillus rhamnosus/*genetics/*metabolism, Polysaccharides, Bacterial/genetics/*metabolismPathogenicity
Pathogenicity25035097Lactobacillus rhamnosus GG suspected infection in a newborn with intrauterine growth restriction.Sadowska-Krawczenko I, Paprzycka M, Korbal P, Wiatrzyk A, Krysztopa-Grzybowska K, Polak M, Czajka U, Lutynska ABenef Microbes10.3920/BM2013.00742014Adolescent, Amplified Fragment Length Polymorphism Analysis, Anti-Bacterial Agents/*therapeutic use, Blood/*microbiology, C-Reactive Protein/analysis, DNA, Bacterial/chemistry/genetics, DNA, Ribosomal/chemistry/genetics, Female, Gram-Positive Bacterial Infections/*diagnosis/microbiology, Humans, Infant, Newborn, Lactobacillus rhamnosus/*isolation & purification, Male, Molecular Typing, Polymerase Chain Reaction, Probiotics/*administration & dosage/adverse effects, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNAPhylogeny
Metabolism25295259Cholesterol assimilation by Lactobacillus probiotic bacteria: an in vitro investigation.Tomaro-Duchesneau C, Jones ML, Shah D, Jain P, Saha S, Prakash SBiomed Res Int10.1155/2014/3803162014Acyl Coenzyme A/antagonists & inhibitors, Amidohydrolases/*metabolism, Cardiovascular Diseases/drug therapy/metabolism/pathology, Cholesterol/*metabolism, Culture Media, Humans, In Vitro Techniques, Lactobacillus plantarum/*metabolism, Probiotics/*metabolism/therapeutic useCultivation
Pathogenicity25438151No evidence of harms of probiotic Lactobacillus rhamnosus GG ATCC 53103 in healthy elderly-a phase I open label study to assess safety, tolerability and cytokine responses.Hibberd PL, Kleimola L, Fiorino AM, Botelho C, Haverkamp M, Andreyeva I, Poutsiaka D, Fraser C, Solano-Aguilar G, Snydman DRPLoS One10.1371/journal.pone.01134562014Aged, Aged, 80 and over, Cytokines/*blood, Drug Stability, Feces/microbiology, Female, *Healthy Volunteers, Humans, *Lactobacillus rhamnosus, Male, Patient Compliance, Probiotics/*adverse effects, *Safety
Pathogenicity25760553A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial.Partty A, Kalliomaki M, Wacklin P, Salminen S, Isolauri EPediatr Res10.1038/pr.2015.512015Adolescent, Age Factors, Asperger Syndrome/*prevention & control, Attention Deficit Disorder with Hyperactivity/*prevention & control, Bifidobacterium/isolation & purification, Dietary Supplements, Feces/microbiology, Gastrointestinal Microbiome/*genetics, Humans, In Situ Hybridization, Fluorescence, Infant, Polymerase Chain Reaction, Probiotics/administration & dosage/*pharmacologyEnzymology
Phylogeny25873374Functional dynamics of the gut microbiome in elderly people during probiotic consumption.Eloe-Fadrosh EA, Brady A, Crabtree J, Drabek EF, Ma B, Mahurkar A, Ravel J, Haverkamp M, Fiorino AM, Botelho C, Andreyeva I, Hibberd PL, Fraser CMmBio10.1128/mBio.00231-152015Aged, Aged, 80 and over, Cluster Analysis, DNA, Bacterial/chemistry/genetics, DNA, Ribosomal/chemistry/genetics, Female, *Gastrointestinal Microbiome, Gastrointestinal Tract/*microbiology, Gene Expression Profiling, Humans, Lactobacillus rhamnosus/*growth & development, Male, *Microbial Interactions, Molecular Sequence Data, *Phylogeny, Probiotics/*administration & dosage, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNAPathogenicity
Genetics26048937Correlation of Lactobacillus rhamnosus Genotypes and Carbohydrate Utilization Signatures Determined by Phenotype Profiling.Ceapa C, Lambert J, van Limpt K, Wels M, Smokvina T, Knol J, Kleerebezem MAppl Environ Microbiol10.1128/AEM.00851-152015Amplified Fragment Length Polymorphism Analysis, *Bacterial Typing Techniques, Carbohydrate Metabolism, *DNA Fingerprinting, Dairy Products/*microbiology, Feces/*microbiology, Fermentation, Genetic Variation, Genome, Bacterial, *Genotype, Humans, Lactobacillus rhamnosus/*classification/genetics/isolation & purification/metabolism, Molecular Sequence Data, *Phenotype, Sequence Analysis, DNAPhenotype
Metabolism26092449An Exopolysaccharide-Deficient Mutant of Lactobacillus rhamnosus GG Efficiently Displays a Protective Llama Antibody Fragment against Rotavirus on Its Surface.Alvarez B, Krogh-Andersen K, Tellgren-Roth C, Martinez N, Gunaydin G, Lin Y, Martin MC, Alvarez MA, Hammarstrom L, Marcotte HAppl Environ Microbiol10.1128/AEM.00945-152015Animals, Bacterial Proteins/genetics/*metabolism, Disease Models, Animal, Female, Humans, Immunoglobulin Fragments/genetics/*metabolism, Lactobacillus rhamnosus/genetics/*metabolism, Male, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Polysaccharides, Bacterial/*deficiency, Probiotics/administration & dosage, Rotavirus/*physiology, Rotavirus Infections/*microbiology/prevention & control/virologyPathogenicity
Pathogenicity26859761Transcriptomic Profile of Whole Blood Cells from Elderly Subjects Fed Probiotic Bacteria Lactobacillus rhamnosus GG ATCC 53103 (LGG) in a Phase I Open Label Study.Solano-Aguilar G, Molokin A, Botelho C, Fiorino AM, Vinyard B, Li R, Chen C, Urban J Jr, Dawson H, Andreyeva I, Haverkamp M, Hibberd PLPLoS One10.1371/journal.pone.01474262016Aged, Aged, 80 and over, Blood Cells/drug effects/*metabolism, Feces/microbiology, *Gene Expression Profiling, Healthy Volunteers, Humans, Lactobacillus rhamnosus/*physiology, Probiotics/adverse effects/*pharmacology, Sequence Analysis, RNA, Time FactorsTranscriptome
Metabolism26913493Supplementation of xylitol-containing chewing gum with probiotics: a double blind, randomised pilot study focusing on saliva flow and saliva properties.Gueimonde L, Vesterlund S, Garcia-Pola MJ, Gueimonde M, Soderling E, Salminen SFood Funct10.1039/c5fo01497b2016Adult, Bifidobacterium/physiology, Chewing Gum/analysis/*microbiology, Double-Blind Method, Female, Food Additives/*analysis/metabolism, Humans, Lactobacillus/physiology, Male, Middle Aged, Probiotics/*analysis/metabolism, Saliva/chemistry/metabolism, Xylitol/*analysis/metabolismPathogenicity
Metabolism26925601Immunological mechanisms involved in probiotic-mediated protection against Citrobacter rodentium-induced colitis.Jiang Y, Yang G, Meng F, Yang W, Hu J, Ye L, Shi C, Wang CBenef Microbes10.3920/BM2015.01192016Citrobacter rodentium/*pathogenicity, Colitis/*pathology, Cytokines/metabolism, Dendritic Cells/immunology, Immune Tolerance, Immunologic Factors/*administration & dosage, Lactobacillus/*immunology, Lymph Nodes/immunology, Probiotics/*administration & dosage, Spleen/immunology, T-Lymphocytes, Regulatory/immunology
Metabolism27102127Characterization of biosurfactants produced by Lactobacillus spp. and their activity against oral streptococci biofilm.Ciandrini E, Campana R, Casettari L, Perinelli DR, Fagioli L, Manti A, Palmieri GF, Papa S, Baffone WAppl Microbiol Biotechnol10.1007/s00253-016-7531-72016Anti-Bacterial Agents/*metabolism, Bacterial Adhesion/drug effects, Biofilms/*growth & development, Lactobacillus acidophilus/*metabolism, Lactobacillus paracasei/*metabolism, Lactobacillus reuteri/*metabolism, Lactobacillus rhamnosus/*metabolism, Microbial Sensitivity Tests, Streptococcus mutans/drug effects/*growth & development, Streptococcus oralis/drug effects/*growth & development, Surface Tension/drug effects, Surface-Active Agents/*metabolism/pharmacology, TitaniumPathogenicity
27702519An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103.Zheng H, Gao M, Ren Y, Lou R, Xie H, Yu W, Liu X, Ma XCarbohydr Polym10.1016/j.carbpol.2016.08.0962016Alginates/*chemistry, Calcium/*chemistry, Edetic Acid/*chemistry, Glucuronic Acid/chemistry, Hexuronic Acids/chemistry, Hydrogels, Hydrogen-Ion Concentration, *Lactobacillus rhamnosus, Probiotics/*administration & dosage
Metabolism27714445Human milk and mucosal lacto- and galacto-N-biose synthesis by transgalactosylation and their prebiotic potential in Lactobacillus species.Bidart GN, Rodriguez-Diaz J, Palomino-Schatzlein M, Monedero V, Yebra MJAppl Microbiol Biotechnol10.1007/s00253-016-7882-02016Acetylgalactosamine/metabolism, Acetylglucosamine/metabolism, Disaccharides/chemistry/*metabolism, Glycoside Hydrolases/*metabolism, Glycosylation, Intestinal Mucosa/*metabolism, Kinetics, Lactobacillus/enzymology/*metabolism, Magnetic Resonance Spectroscopy, Milk, Human/*metabolism, Nucleic Acid Hybridization, *PrebioticsEnzymology
Pathogenicity27741159Protective Role of Postbiotic Mediators Secreted by Lactobacillus rhamnosus GG Versus Lipopolysaccharide-induced Damage in Human Colonic Smooth Muscle Cells.Cicenia A, Santangelo F, Gambardella L, Pallotta L, Iebba V, Scirocco A, Marignani M, Tellan G, Carabotti M, Corazziari ES, Schippa S, Severi CJ Clin Gastroenterol10.1097/MCG.00000000000006812016Anti-Bacterial Agents/biosynthesis/*metabolism, Bacteriocins/biosynthesis/*metabolism, Colon/cytology/microbiology, Endotoxins/*toxicity, Humans, Lactobacillus rhamnosus/*physiology, Myocytes, Smooth Muscle/drug effects/*microbiology, Probiotics/metabolism/therapeutic useMetabolism
Stress28193570Live and heat-killed Lactobacillus spp. interfere with Streptococcus mutans and Streptococcus oralis during biofilm development on titanium surface.Ciandrini E, Campana R, Baffone WArch Oral Biol10.1016/j.archoralbio.2017.02.0042017*Antibiosis, Bacterial Adhesion, Biofilms/*growth & development, Hot Temperature, Lactobacillus/*physiology, Streptococcus mutans/*growth & development, Streptococcus oralis/*growth & development, Surface Properties, Titanium/*chemistry
Metabolism28244112In vitro fermentation of oat beta-glucan and hydrolysates by fecal microbiota and selected probiotic strains.Dong JL, Yu X, Dong LE, Shen RLJ Sci Food Agric10.1002/jsfa.82922017Animals, Avena/metabolism/*microbiology, Fatty Acids, Volatile/analysis/metabolism, Feces/*microbiology, Fermentation, Hydrolysis, Lactobacillus/classification/isolation & purification/*metabolism, Male, *Microbiota, Probiotics/analysis/*metabolism, Rats, Rats, Sprague-Dawley, beta-Glucans/*metabolismPhylogeny
28411984Capability of exopolysaccharide-producing Lactobacillus paraplantarum BGCG11 and its non-producing isogenic strain NB1, to counteract the effect of enteropathogens upon the epithelial cell line HT29-MTX.Zivkovic M, Hidalgo-Cantabrana C, Kojic M, Gueimonde M, Golic N, Ruas-Madiedo PFood Res Int10.1016/j.foodres.2015.05.0122015
28579977In silico Prediction, in vitro Antibacterial Spectrum, and Physicochemical Properties of a Putative Bacteriocin Produced by Lactobacillus rhamnosus Strain L156.4.Oliveira LC, Silveira AMM, Monteiro AS, Dos Santos VL, Nicoli JR, Azevedo VAC, Soares SC, Dias-Souza MV, Nardi RMDFront Microbiol10.3389/fmicb.2017.008762017
Metabolism28843807A comparative study of procedures for binding of aflatoxin M1 to Lactobacillus rhamnosus GG.Assaf JC, Atoui A, Khoury AE, Chokr A, Louka NBraz J Microbiol10.1016/j.bjm.2017.05.0032017Aflatoxin M1/*chemistry/metabolism, Animals, Culture Media/chemistry, Lactobacillus rhamnosus/*chemistry/metabolismCultivation
Pathogenicity28947466Randomised controlled trial of Lactobacillus rhamnosus (LGG) versus placebo in children presenting to the emergency department with acute gastroenteritis: the PECARN probiotic study protocol.Schnadower D, Tarr PI, Casper TC, Gorelick MH, Dean MJ, O'Connell KJ, Mahajan P, Chun TH, Bhatt SR, Roskind CG, Powell EC, Rogers AJ, Vance C, Sapien RE, Gao F, Freedman SBBMJ Open10.1136/bmjopen-2017-0181152017Acute Disease, Child, Child, Preschool, Clinical Protocols, Double-Blind Method, Emergency Service, Hospital, Female, Gastroenteritis/*therapy, Humans, Infant, Intention to Treat Analysis, *Lactobacillus rhamnosus, Male, Probiotics/*administration & dosage/adverse effects, Severity of Illness Index
Pathogenicity29063625Effect of phenolic compounds on the growth of selected probiotic and pathogenic bacteria.Pacheco-Ordaz R, Wall-Medrano A, Goni MG, Ramos-Clamont-Montfort G, Ayala-Zavala JF, Gonzalez-Aguilar GALett Appl Microbiol10.1111/lam.128142018Anti-Bacterial Agents/*pharmacology, Escherichia coli/*drug effects/growth & development, Humans, Hydroxybenzoates/pharmacology, Lactobacillus/*drug effects/growth & development, Phenols/chemistry/*pharmacology, Probiotics/*analysis, Salmonella typhimurium/*drug effects/growth & development
Pathogenicity29402455Routine Supplementation of Lactobacillus rhamnosus GG and Risk of Necrotizing Enterocolitis in Very Low Birth Weight Infants.Kane AF, Bhatia AD, Denning PW, Shane AL, Patel RMJ Pediatr10.1016/j.jpeds.2017.11.0552018Enterocolitis, Necrotizing/epidemiology/*prevention & control, Female, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Very Low Birth Weight, *Lactobacillus rhamnosus, Logistic Models, Male, Probiotics/*administration & dosage/adverse effects, Retrospective Studies, Risk Factors
Pathogenicity29455334Septicemia from Lactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation.Koyama S, Fujita H, Shimosato T, Kamijo A, Ishiyama Y, Yamamoto E, Ishii Y, Hattori Y, Hagihara M, Yamazaki E, Tomita N, Nakajima HProbiotics Antimicrob Proteins10.1007/s12602-018-9399-62019Hematopoietic Stem Cell Transplantation, Humans, Lactobacillus rhamnosus/growth & development/*physiology, Leukemia/*therapy, Male, Middle Aged, Probiotics/*adverse effects/analysis, Sepsis/*etiology/microbiology, Transplantation, Autologous, Yogurt/*adverse effects/microbiology
Phylogeny29599835Antibacterial effects of bacteriocins isolated from Lactobacillus rhamnosus (ATCC 53103) in a rabbit model of knee implant infection.Zhou B, Zhang DExp Ther Med10.3892/etm.2018.57902018
Pathogenicity29762266Flow Cytometry: Evolution of Microbiological Methods for Probiotics Enumeration.Pane M, Allesina S, Amoruso A, Nicola S, Deidda F, Mogna LJ Clin Gastroenterol10.1097/MCG.00000000000010572018Animals, Bacterial Load/*methods, Flow Cytometry/*methods, Food Microbiology/*methods, Humans, Lactobacillus rhamnosus/*growth & development, Milk/microbiology, Probiotics/*analysis, Reproducibility of ResultsBiotechnology
Cultivation30086200Lactobacillus rhamnosus LRB mediated inhibition of oral streptococci.Biswas S, Turner L, Biswas IMol Oral Microbiol10.1111/omi.122422018*Antibiosis, Child, Culture Media, Conditioned/chemistry, Humans, Lactic Acid/*metabolism, Lactobacillus rhamnosus/genetics/isolation & purification/*physiology, *Probiotics, Streptococcus/*growth & developmentPathogenicity
Phylogeny30319846Evaluation of probiotic potential and anti-hyperglycemic properties of a novel Lactobacillus strain isolated from water kefir grains.Koh WY, Utra U, Ahmad R, Rather IA, Park YHFood Sci Biotechnol10.1007/s10068-018-0360-y2018
30666850Oral administration of Lactobacillus rhamnosus GG to newborn piglets augments gut barrier function in pre-weaning piglets.Wang Y, Gong L, Wu YP, Cui ZW, Wang YQ, Huang Y, Zhang XP, Li WFJ Zhejiang Univ Sci B10.1631/jzus.B18000222019Administration, Oral, Animals, Animals, Newborn, Cytokines/genetics, Female, Gastrointestinal Microbiome, Immunity, Innate, Intestinal Mucosa/*immunology, *Lactobacillus rhamnosus, Male, Probiotics/*administration & dosage, Signal Transduction, Swine, Weaning
Biotechnology30884731Matrix-wise evaluation of in vivo and in vitro efficiencies of L. rhamnosus GG-fortified beverages.Sireswar S, Dey GFood Res Int10.1016/j.foodres.2018.10.0772018Animals, Beverages/analysis/*microbiology, Disease Models, Animal, Enterocolitis/pathology/prevention & control, Food Microbiology, Fruit/*chemistry, Gastrointestinal Microbiome/physiology, Gastrointestinal Tract/microbiology, Hippophae/*chemistry, Hydroxybenzoates/analysis, Lactobacillus rhamnosus/*physiology, Malus/*chemistry, Probiotics/*therapeutic use, Quercetin/analogs & derivatives/analysis, Rheology, Shear Strength, Zebrafish
Pathogenicity31965835Probiotics exert reciprocal effects on autophagy and interleukin-1beta expression in Salmonella-infected intestinal epithelial cells via autophagy-related 16L1 protein.Lai WT, Huang FCBenef Microbes10.3920/BM2019.00462019Autophagy/*drug effects, Autophagy-Related Proteins/genetics/*metabolism, Bifidobacterium longum/physiology, Caco-2 Cells, Colony Count, Microbial, Gene Expression/drug effects, Gene Expression Regulation/drug effects, Gene Silencing, Humans, Interleukin-1beta/*genetics, Intestinal Mucosa/*drug effects/metabolism/microbiology/pathology, Lactobacillus rhamnosus/physiology, Microtubule-Associated Proteins/metabolism, Nod2 Signaling Adaptor Protein/genetics/metabolism, Probiotics/*pharmacology, Receptors, Calcitriol/genetics, Salmonella typhimurium/*drug effects/growth & development/metabolismMetabolism
Pathogenicity31970371Effects of regular and decaffeinated roasted coffee (Coffea arabica and Coffea canephora) extracts and bioactive compounds on in vitro probiotic bacterial growth.Sales AL, dePaula J, Mellinger Silva C, Cruz A, Lemos Miguel MA, Farah AFood Funct10.1039/c9fo02589h2020Caffeine/*pharmacology, *Coffea, Coffee/*chemistry, Escherichia coli/*drug effects, Food Handling, Humans, Lactobacillus/*drug effects, Plant Extracts/*pharmacology, *Probiotics
Pathogenicity32154524Adhesion and anti-inflammatory potential of Lactobacillus rhamnosus GG in a sea buckthorn based beverage matrix.Sireswar S, Biswas S, Dey GFood Funct10.1039/c9fo02249j2020Animals, *Beverages, *Cell Adhesion, Cell Survival, HCT116 Cells, *Hippophae, Humans, Inflammation/chemically induced/drug therapy, *Lactobacillus rhamnosus, Lipopolysaccharides/toxicity, Zebrafish
Metabolism32169430Lactococcus lactis Subspecies cremoris Elicits Protection Against Metabolic Changes Induced by a Western-Style Diet.Naudin CR, Maner-Smith K, Owens JA, Wynn GM, Robinson BS, Matthews JD, Reedy AR, Luo L, Wolfarth AA, Darby TM, Ortlund EA, Jones RMGastroenterology10.1053/j.gastro.2020.03.0102020Animals, Cholesterol/blood/metabolism, Diet, Western/*adverse effects, Disease Models, Animal, Dyslipidemias/blood/diagnosis/metabolism/*prevention & control, Female, Humans, Insulin Resistance, *Lactococcus, Liver/pathology, Mice, Non-alcoholic Fatty Liver Disease/blood/metabolism/pathology/*prevention & control, Probiotics/*administration & dosage, Weight GainPathogenicity
32256407A Pilot Randomized Control Trial With the Probiotic Strain Lactobacillus rhamnosus GG (LGG) in ADHD: Children and Adolescents Report Better Health-Related Quality of Life.Kumperscak HG, Gricar A, Ulen I, Micetic-Turk DFront Psychiatry10.3389/fpsyt.2020.001812020
Pathogenicity32307246Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for clinicians.Chiang MC, Chen CL, Feng Y, Chen CC, Lien R, Chiu CHJ Microbiol Immunol Infect10.1016/j.jmii.2020.03.0292020Administration, Oral, Anti-Bacterial Agents/therapeutic use, Biofilms/growth & development, Enterocolitis, Necrotizing/prevention & control, Humans, Infant, Extremely Premature, Infant, Newborn, Lactobacillus rhamnosus/drug effects/genetics/isolation & purification/*pathogenicity, Probiotics/administration & dosage/*adverse effects, Sepsis/diagnosis/drug therapy/*etiologyEnzymology
Pathogenicity32332478Probiotics and Preterm Infants: A Position Paper by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Committee on Nutrition and the European Society for Paediatric Gastroenterology Hepatology and Nutrition Working Group for Probiotics and Prebiotics.van den Akker CHP, van Goudoever JB, Shamir R, Domellof M, Embleton ND, Hojsak I, Lapillonne A, Mihatsch WA, Berni Canani R, Bronsky J, Campoy C, Fewtrell MS, Fidler Mis N, Guarino A, Hulst JM, Indrio F, Kolacek S, Orel R, Vandenplas Y, Weizman Z, Szajewska HJ Pediatr Gastroenterol Nutr10.1097/MPG.00000000000026552020Child, *Enterocolitis, Necrotizing/epidemiology/prevention & control, *Gastroenterology, Humans, Infant, Infant, Newborn, Infant, Premature, Prebiotics, *Probiotics
Pathogenicity32512895Anti-Inflammatory and Gut Microbiota Modulatory Effect of Lactobacillus rhamnosus Strain LDTM 7511 in a Dextran Sulfate Sodium-Induced Colitis Murine Model.Yeo S, Park H, Seo E, Kim J, Kim BK, Choi IS, Huh CSMicroorganisms10.3390/microorganisms80608452020
Pathogenicity32517123Lactobacillus rhamnosus GG (ATCC 53103) for the Management of Infantile Colic: A Randomized Controlled Trial.Savino F, Montanari P, Galliano I, Dapra V, Bergallo MNutrients10.3390/nu120616932020Adult, Animals, *Breast Feeding, Colic/*therapy, *Diet, *Dietary Supplements, Feces/chemistry, Female, *Gastrointestinal Microbiome, Humans, Infant, Infant, Newborn, *Lactobacillus rhamnosus, Leukocyte L1 Antigen Complex/metabolism, Male, Milk/adverse effects, Probiotics/*administration & dosage, Treatment Outcome, Young AdultMetabolism
32621828New insights in enumeration methodologies of probiotic cells in finished products.Foglia C, Allesina S, Amoruso A, De Prisco A, Pane MJ Microbiol Methods10.1016/j.mimet.2020.1059932020Colony Count, Microbial/*methods, Flow Cytometry/*methods, Lactobacillus rhamnosus/*growth & development, Microbial Viability, Probiotics/*analysis
Pathogenicity32759442Study of anti-virus actions of metabolites of lactobacteria.Kalinichenko SV, Melentyevsmall a, Cyrillic KV, Manee H, Dubinina NV, Zvereva NV, Toryanik II, Popova NG, Pakhomov OVWiad Lek2020Antiviral Agents, *Enterovirus Infections, Feces, Humans, *Lactobacillus rhamnosus, *Probiotics
32793131First Evidence of Acyl-Hydrolase/Lipase Activity From Human Probiotic Bacteria: Lactobacillus rhamnosus GG and Bifidobacterium longum NCC 2705.Manasian P, Bustos AS, Palsson B, Hakansson A, Penarrieta JM, Nilsson L, Linares-Pasten JAFront Microbiol10.3389/fmicb.2020.015342020
32847138Anti-Biofilm Properties of Saccharomyces cerevisiae CNCM I-3856 and Lacticaseibacillus rhamnosus ATCC 53103 Probiotics against G. vaginalis.Sabbatini S, Monari C, Ballet N, Decherf AC, Bozza S, Camilloni B, Perito S, Vecchiarelli AMicroorganisms10.3390/microorganisms80912942020
32978757Development and Comparative Evaluation of a Novel Fermented Juice Mixture with Probiotic Strains of Lactic Acid Bacteria and Bifidobacteria.Guney D, Gungormusler MProbiotics Antimicrob Proteins10.1007/s12602-020-09710-22020*Bifidobacterium animalis, Fermented Beverages/*microbiology, Fruit and Vegetable Juices/*microbiology, *Lactobacillales, *Probiotics
33247747A Validated Real-Time PCR Method for the Specific Identification of Probiotic Strain Lactobacillus rhamnosus GG (ATCC 53103).Shehata HR, Newmaster SGJ AOAC Int10.1093/jaoacint/qsaa0632020*Lactobacillus rhamnosus/genetics, *Probiotics, *Real-Time Polymerase Chain Reaction, Reproducibility of Results
33391230Probiotic Lactobacillus rhamnosus GG Promotes Mouse Gut Microbiota Diversity and T Cell Differentiation.Shi CW, Cheng MY, Yang X, Lu YY, Yin HD, Zeng Y, Wang RY, Jiang YL, Yang WT, Wang JZ, Zhao DD, Huang HB, Ye LP, Cao X, Yang GL, Wang CFFront Microbiol10.3389/fmicb.2020.6077352020
Metabolism33450655Specific Lactobacillus probiotic strains decrease transepithelial glucose transport through GLUT2 downregulation in intestinal epithelial cell models.Primec M, Skorjanc D, Langerholc T, Micetic-Turk D, Gorenjak MNutr Res10.1016/j.nutres.2020.11.0082020Animals, Biological Transport, Caco-2 Cells, Cell Line, Down-Regulation, Enterocytes/*metabolism, Epithelial Cells/metabolism, Glucose/*metabolism, Glucose Transporter Type 2/*genetics/metabolism, Humans, Intestinal Mucosa/cytology/*metabolism, *Lactobacillus, *Probiotics, Sodium-Glucose Transporter 1/genetics/metabolism, Swine, Transcription, GeneticPathogenicity
33678902Biodiversity of meatborne Listeria spp. in Himachal Pradesh and their interaction with indigenous probiotics.Sharma A, Kanwar SS, Thakur SDJ Food Sci Technol10.1007/s13197-020-04854-z2020
33711368Microencapsulation of Lactobacillus casei and Lactobacillus rhamnosus in pectin and pectin-inulin microgel particles: Effect on bacterial survival under storage conditions.Tarifa MC, Piqueras CM, Genovese DB, Brugnoni LIInt J Biol Macromol10.1016/j.ijbiomac.2021.03.0382021Capsules/*chemistry, Inulin/*chemistry, Lactobacillus casei/*growth & development, Lactobacillus rhamnosus/*growth & development, Microbial Viability, Microgels/*chemistry, Pectins/*chemistry
Metabolism33932824Probiotics Lactobacillus rhamnosus GG ATCC53103 and Lactobacillus plantarum JL01 induce cytokine alterations by the production of TCDA, DHA, and succinic and palmitic acids, and enhance immunity of weaned piglets.Geng T, He F, Su S, Sun K, Zhao L, Zhao Y, Bao N, Pan L, Sun HRes Vet Sci10.1016/j.rvsc.2021.04.0112021Animals, Cytokines/genetics/*metabolism, Docosahexaenoic Acids/metabolism, Gene Expression Regulation/drug effects, Intestinal Mucosa/metabolism, *Lactobacillus plantarum, *Lactobacillus rhamnosus, Palmitic Acids/metabolism, *Probiotics, Random Allocation, Succinic Acid/metabolism, Swine/*metabolism, Taurochenodeoxycholic Acid/metabolism, WeaningBiotechnology
Enzymology34591288Enumeration of Probiotic Strain Lacticaseibacillus rhamnosus GG (ATCC 53103) Using Viability Real-time PCR.Shehata HR, Newmaster SGProbiotics Antimicrob Proteins10.1007/s12602-021-09849-62021Lactobacillus rhamnosus/*isolation & purification, *Probiotics, Real-Time Polymerase Chain ReactionPhylogeny
Pathogenicity34600663Influence of fruit-based beverages on efficacy of Lacticaseibacillus rhamnosus GG (Lactobacillus rhamnosus GG) against DSS-induced intestinal inflammation.Sireswar S, Dey G, Biswas SFood Res Int10.1016/j.foodres.2021.1106612021Animals, Beverages, Fruit, Inflammation, *Lactobacillus rhamnosus, Zebrafish
Stress34899662Ribosome Profiling and RNA Sequencing Reveal Genome-Wide Cellular Translation and Transcription Regulation Under Osmotic Stress in Lactobacillus rhamnosus ATCC 53103.Fan X, Bao T, Yi H, Zhang Z, Zhang K, Liu X, Lin X, Zhang Z, Feng ZFront Microbiol10.3389/fmicb.2021.7814542021
Pathogenicity35123664Probiotic peanut oral immunotherapy versus oral immunotherapy and placebo in children with peanut allergy in Australia (PPOIT-003): a multicentre, randomised, phase 2b trial.Loke P, Orsini F, Lozinsky AC, Gold M, O'Sullivan MD, Quinn P, Lloyd M, Ashley SE, Pitkin S, Axelrad C, Metcalfe JR, Su EL, Tey D, Robinson MN, Allen KJ, Prescott SL, Galvin AD, Tang MLKLancet Child Adolesc Health10.1016/S2352-4642(22)00006-22022Administration, Oral, Allergens/*administration & dosage, Arachis/*immunology, Australia, Child, Child, Preschool, Desensitization, Immunologic/*methods, Dietary Proteins/administration & dosage, Double-Blind Method, Female, Humans, Immunologic Factors/*administration & dosage, Infant, Lactobacillus rhamnosus/*immunology, Male, Peanut Hypersensitivity/*therapy, Probiotics/*administration & dosage, Quality of Life, Tertiary Care Centers, Treatment Outcome
Pathogenicity35334835Lactobacilli Infection Case Reports in the Last Three Years and Safety Implications.Rossi F, Amadoro C, Gasperi M, Colavita GNutrients10.3390/nu140611782022Humans, Lactobacillus/genetics, *Lactobacillus rhamnosus/genetics, *Microbiota, *Probiotics
35549737Improvement of probiotic viability through the design of novel biomaterials using coffee pulp wastes and Lactobacillus rhamnosus.Rosales Delgado S, Alzate Arbelaez AF, Zapata Acosta K, Cortes FB, Rojano BAFood Sci Technol Int10.1177/108201322211006832022
Stress35626981Ribosome Profiling Reveals Genome-Wide Cellular Translational Regulation in Lacticaseibacillus rhamnosus ATCC 53103 under Acid Stress.Fan X, Zhang K, Zhang Z, Zhang Z, Lin X, Liu X, Feng Z, Yi HFoods10.3390/foods111014112022
35812820Rationale, design, and methods: A randomized placebo-controlled trial of an immunomodulatory probiotic intervention for Veterans with PTSD.Brenner LA, Stearns-Yoder KA, Stamper CE, Hoisington AJ, Brostow DP, Hoffmire CA, Forster JE, Donovan ML, Ryan AT, Postolache TT, Lowry CAContemp Clin Trials Commun10.1016/j.conctc.2022.1009602022
Phylogeny36141000Anti-Biofilm Activity of Cell Free Supernatants of Selected Lactic Acid Bacteria against Listeria monocytogenes Isolated from Avocado and Cucumber Fruits, and from an Avocado Processing Plant.Masebe RD, Thantsha MSFoods10.3390/foods111828722022
Pathogenicity36401067In vitro characterization of lactic acid bacterial strains isolated from fermented foods with anti-inflammatory and dipeptidyl peptidase-IV inhibition potential.Bhatia R, Singh S, Maurya R, Bhadada SK, Bishnoi M, Chopra K, Joshi SR, Kondepudi KKBraz J Microbiol10.1007/s42770-022-00872-52022
36517529In vitro assessment of probiotic attributes for strains contained in commercial formulations.Mazzantini D, Calvigioni M, Celandroni F, Lupetti A, Ghelardi ESci Rep10.1038/s41598-022-25688-z2022

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52036Curators of the CCUGhttps://www.ccug.se/strain?id=34291Culture Collection University of Gothenburg (CCUG) (CCUG 34291)
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg OvermannAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)https://diaspora-project.de/progress.html#genomes
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68371Automatically annotated from API 50CH acid
68381Automatically annotated from API rID32STR
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