Strain identifier

BacDive ID: 14702

Type strain: Yes

Species: Lactococcus lactis

Strain Designation: OJ, N30

Strain history: CIP <- 1970, P. Cayeux, Inst. Pasteur, Paris, France: strain N30 <- P.M.F. Shattock, Reading, UK: strain lactis OJ

NCBI tax ID(s): 1358 (species)

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General

@ref: 8850

BacDive-ID: 14702

DSM-Number: 20481

keywords: genome sequence, 16S sequence, Bacteria, facultative anaerobe, mesophilic, Gram-positive, coccus-shaped, human pathogen

description: Lactococcus lactis OJ is a facultative anaerobe, mesophilic, Gram-positive human pathogen that was isolated from Unknown source.

NCBI tax id

  • NCBI tax id: 1358
  • Matching level: species

strain history

@refhistory
8850<- NCDO <- S. Orla-Jensen
67770DSM 20481 <-- NCDO 604 <-- S. Orla-Jensen.
120528CIP <- 1970, P. Cayeux, Inst. Pasteur, Paris, France: strain N30 <- P.M.F. Shattock, Reading, UK: strain lactis OJ

doi: 10.13145/bacdive14702.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacillota
  • domain: Bacteria
  • phylum: Bacillota
  • class: Bacilli
  • order: Lactobacillales
  • family: Streptococcaceae
  • genus: Lactococcus
  • species: Lactococcus lactis
  • full scientific name: Lactococcus lactis (Lister 1873) Schleifer et al. 1986

  • synonyms

    @refsynonym
    20215Streptococcus lactis
    20215Bacterium lactis
    20215Lactobacillus xylosus
    20215Streptococcus lactis subsp. diacetilactis

@ref: 8850

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Lactobacillales

family: Streptococcaceae

genus: Lactococcus

species: Lactococcus lactis

full scientific name: Lactococcus lactis (Lister 1873) Schleifer et al. 1986

strain designation: OJ, N30

type strain: yes

Morphology

cell morphology

  • @ref: 120528
  • gram stain: positive
  • cell shape: coccus-shaped
  • motility: no

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
8850CORYNEBACTERIUM AGAR (DSMZ Medium 53)yeshttps://mediadive.dsmz.de/medium/53Name: CORYNEBACTERIUM AGAR (DSMZ Medium 53) Composition: Agar 15.0 g/l Casein peptone 10.0 g/l NaCl 5.0 g/l Glucose 5.0 g/l Yeast extract 5.0 g/l Distilled water
36188MEDIUM 40- for Lactobacillus and LeuconostocyesDistilled water make up to (1000.000 ml);Man Rogosa Sharp agar (68.000 g)
120528CIP Medium 40yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=40

culture temp

@refgrowthtypetemperaturerange
8850positivegrowth30mesophilic
36188positivegrowth30mesophilic
67770positivegrowth30mesophilic
120528positivegrowth30-37mesophilic
120528nogrowth10psychrophilic
120528nogrowth41thermophilic

Physiology and metabolism

oxygen tolerance

  • @ref: 120528
  • oxygen tolerance: facultative anaerobe

compound production

  • @ref: 20216
  • compound: D-lactic acid (sarcolactic acid)

halophily

@refsaltgrowthtested relationconcentration
120528NaClpositivegrowth0-4 %
120528NaClnogrowth6 %
120528NaClnogrowth8 %
120528NaClnogrowth10 %

murein

  • @ref: 8850
  • murein short key: A11.31
  • type: A4alpha L-Lys-D-Asp

metabolite utilization

@refmetaboliteutilization activitykind of utilization testedChebi-ID
68371Potassium 5-ketogluconate-builds acid from
68371Potassium 2-ketogluconate-builds acid from
68371gluconate-builds acid from24265
68371L-arabitol-builds acid from18403
68371D-arabitol-builds acid from18333
68371L-fucose-builds acid from18287
68371D-fucose-builds acid from28847
68371D-tagatose-builds acid from16443
68371D-lyxose-builds acid from62318
68371turanose-builds acid from32528
68371xylitol-builds acid from17151
68371glycogen-builds acid from28087
68371melezitose-builds acid from6731
68371inulin-builds acid from15443
68371trehalose+builds acid from27082
68371melibiose-builds acid from28053
68371lactose+builds acid from17716
68371maltose+builds acid from17306
68371cellobiose+builds acid from17057
68371salicin+builds acid from17814
68371esculin+builds acid from4853
68371arbutin+builds acid from18305
68371N-acetylglucosamine+builds acid from59640
68371methyl alpha-D-mannoside-builds acid from43943
68371D-sorbitol-builds acid from17924
68371D-mannitol-builds acid from16899
68371myo-inositol-builds acid from17268
68371galactitol-builds acid from16813
68371L-rhamnose-builds acid from62345
68371L-sorbose-builds acid from17266
68371D-mannose+builds acid from16024
68371D-fructose+builds acid from15824
68371D-glucose+builds acid from17634
68371D-galactose+builds acid from12936
68371methyl beta-D-xylopyranoside-builds acid from74863
68371ribitol-builds acid from15963
68371L-xylose-builds acid from65328
68371D-xylose+builds acid from65327
68371D-ribose+builds acid from16988
68371L-arabinose-builds acid from30849
68371D-arabinose-builds acid from17108
68371erythritol-builds acid from17113
68371glycerol-builds acid from17754
120528nitrate-reduction17632
120528nitrite-reduction16301
120528nitrate+respiration17632
68381arginine+hydrolysis29016
68381D-ribose+builds acid from16988
68381D-mannitol-builds acid from16899
68381sorbitol-builds acid from30911
68381lactose+builds acid from17716
68381raffinose-builds acid from16634
68381sucrose-builds acid from17992
68381L-arabinose-builds acid from30849
68381D-arabitol-builds acid from18333
68381hippurate-hydrolysis606565
68381glycogen-builds acid from28087
68381pullulan-builds acid from27941
68381maltose+builds acid from17306
68381melibiose-builds acid from28053
68381melezitose-builds acid from6731
68381D-tagatose-builds acid from16443
68381urea-hydrolysis16199

metabolite production

@refChebi-IDmetaboliteproduction
6777016865gamma-aminobutyric acidyes
12052835581indoleno

metabolite tests

  • @ref: 120528
  • Chebi-ID: 15688
  • metabolite: acetoin
  • voges-proskauer-test: -

enzymes

@refvalueactivityec
68381urease-3.5.1.5
68381glycyl tryptophan arylamidase-
68381N-acetyl-beta-glucosaminidase-3.2.1.52
68381pyrrolidonyl arylamidase-3.4.19.3
68381beta-galactosidase-3.2.1.23
68381Alanyl-Phenylalanyl-Proline arylamidase+
68381alkaline phosphatase-3.1.3.1
68381alpha-galactosidase-3.2.1.22
68381beta-glucuronidase-3.2.1.31
68381arginine dihydrolase+3.5.3.6
120528oxidase-
120528beta-galactosidase-3.2.1.23
120528alcohol dehydrogenase+1.1.1.1
120528catalase-1.11.1.6
120528lysine decarboxylase-4.1.1.18
120528ornithine decarboxylase-4.1.1.17
120528urease-3.5.1.5
68382alkaline phosphatase-3.1.3.1
68382esterase (C 4)-
68382esterase lipase (C 8)-
68382lipase (C 14)-
68382leucine arylamidase-3.4.11.1
68382valine arylamidase-
68382cystine arylamidase-3.4.11.3
68382trypsin-3.4.21.4
68382alpha-chymotrypsin-3.4.21.1
68382acid phosphatase-3.1.3.2
68382naphthol-AS-BI-phosphohydrolase-
68382alpha-galactosidase-3.2.1.22
68382beta-galactosidase-3.2.1.23
68382beta-glucuronidase-3.2.1.31
68382alpha-glucosidase-3.2.1.20
68382beta-glucosidase-3.2.1.21
68382N-acetyl-beta-glucosaminidase-3.2.1.52
68382alpha-mannosidase-3.2.1.24
68382alpha-fucosidase-3.2.1.51

API zym

@refControlAlkaline phosphataseEsteraseEsterase LipaseLipaseLeucine arylamidaseValine arylamidaseCystine arylamidaseTrypsinalpha- ChymotrypsinAcid phosphataseNaphthol-AS-BI-phosphohydrolasealpha- Galactosidasebeta- Galactosidasebeta- Glucuronidasealpha- Glucosidasebeta- GlucosidaseN-acetyl-beta- glucosaminidasealpha- Mannosidasealpha- Fucosidase
120528--------------------

API 50CHac

@refQGLYERYDARALARARIBDXYLLXYLADOMDXGALGLUFRUMNESBERHADULINOMANSORMDMMDGNAGAMYARBESCSALCELMALLACMELSACTREINUMLZRAFAMDGLYGXLTGENTURLYXTAGDFUCLFUCDARLLARLGNT2KG5KG
8850-----++---++++--------++++++++--+------+----------
8850-----++---++++--------+-++++++--+-----------------
8850-----++---++++--------++/-++++++--+-----------------
8850-----++---++++-------+++++++++-++--++--+----------

API rID32STR

@refADH Argbeta GLUbeta GARbeta GURalpha GALPALRIBMANSORLACTRERAFSACLARADARLCDEXVPAPPAbeta GALPyrAbeta NAGGTAHIPGLYGPULMALMELMLZMbeta DGTAGbeta MANURE
8850++----+--++----+-+-------+--+---
8850++----+--++----+-+-------+------
8850++/-----+--+-------+-------+------
8850++----+--++----+++-------+--+-+/--
8850++----+--++----+-+-------+--+---
8850++----+--++----+-+-------+--+---
8850++----+--++----+-+-------+------

Isolation, sampling and environmental information

isolation

  • @ref: 120528
  • sample type: Unknown source

taxonmaps

  • @ref: 69479
  • File name: preview.99_170.png
  • url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_58;96_124;97_132;98_149;99_170&stattab=map
  • Last taxonomy: Lactococcus
  • 16S sequence: AB100803
  • Sequence Identity:
  • Total samples: 157686
  • soil counts: 7135
  • aquatic counts: 13841
  • animal counts: 132033
  • plant counts: 4677

Safety information

risk assessment

@refpathogenicity humanbiosafety levelbiosafety level comment
8850yes, in single cases1Risk group (German classification)
1205281Risk group (French classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
20218Lactococcus lactis subsp. lactis strain NIZO29T 16S ribosomal RNA gene, partial sequenceEU091395601ena1360
20218Streptococcus lactis 16S ribosomal RNAM588371552ena1358
20218Lactococcus lactis subsp. lactis strain DSM 20481 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer and tRNA-Ala gene, complete sequence; and 23S ribosomal RNA gene, partial sequenceDQ788632562ena1360
20218Lactococcus lactis subsp. lactis strain KCTC 3769 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequenceHM241921515ena1360
20218Lactococcus lactis subsp. lactis gene for 16S rRNA, partial sequence, strain: NBRC 100933AB6812951472ena1360
20218Lactococcus lactis subsp. lactis gene for 16S rRNA, partial sequence, strain: NCDO 604TAB1008031499ena1360

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Lactococcus lactis ATCC 19435GCA_900099625scaffoldncbi1358
66792Lactococcus lactis subsp. lactis JCM 5805 = NBRC 100933GCA_000615405contigncbi1236944
66792Lactococcus lactis strain ATCC 194351358.88wgspatric1358
66792Lactococcus lactis strain FDAARGOS_8651358.1330completepatric1358
66792Lactococcus lactis subsp. lactis JCM 58051360.89wgspatric1360
66792Lactococcus lactis subsp. lactis JCM 5805 = NBRC 1009331236944.3wgspatric1236944
66792Lactococcus lactis subsp. lactis JCM 5805 = NBRC 1009331236944.5wgspatric1236944
66792Lactococcus lactis subsp. lactis strain ATCC 194351360.96wgspatric1360
66792Lactococcus lactis subsp. lactis strain ATCC 194351360.523wgspatric1360
66792Lactococcus lactis subsp. lactis strain ATCC 194351360.260wgspatric1360
66792Lactococcus lactis lactis ATCC 194352695420395draftimg1360
66792Lactococcus lactis lactis JCM 5805, NBRC 1009332609460085draftimg1236944
66792Lactococcus lactis lactis JCM 5805, NBRC 1009332731957554draftimg1236944
66792Lactococcus lactis lactis NCDO 6042597490350draftimg1360
66792Lactococcus lactis lactis ATCC 194352871632203draftimg1360
66792Lactococcus lactis lactis JCM 58052645728002draftimg1360
67770Lactococcus lactis subsp. lactis JCM 5805GCA_000835975contigncbi1360
67770Lactococcus lactis subsp. lactis JCM 5805 = NBRC 100933GCA_001514475contigncbi1236944
67770Lactococcus lactis subsp. lactis ATCC 19435GCA_002441815contigncbi1360
67770Lactococcus lactis subsp. lactis ATCC 19435GCA_001456385contigncbi1360
67770Lactococcus lactis subsp. lactis ATCC 19435GCA_004354485scaffoldncbi1360

GC content

@refGC-contentmethod
885035.8
6777035.8thermal denaturation, midpoint method (Tm)

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
motileno94.764no
gram-positiveyes94.93no
anaerobicno96.089no
halophileyes63.543no
spore-formingno90.706no
thermophileno99.798no
glucose-utilyes90.358no
flagellatedno96.545no
aerobicno97.267no
glucose-fermentyes86.748no

External links

@ref: 8850

culture collection no.: DSM 20481, ATCC 19435, CCM 1877, NCDO 604, NCIB 6681, NCTC 6681, WDCM 00016, JCM 5805, ATCC 9936, BCC 49730, BCRC 12312, CCUG 32211, CCUG 7980, CECT 185, CIP 70.56, HAMBI 1591, KCTC 3769, LMG 6890, NBIMCC 4000, NBRC 100933, NCAIM B.02070, NCIMB 6681, NRIC 1149, VKM B-1662, VTT E-90395

straininfo link

  • @ref: 83821
  • straininfo: 11441

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Enzymology1123256Characterization of group N streptococcus lipoteichoic acid.Wicken AJ, Knox KWInfect Immun10.1128/iai.11.5.973-981.19751975Cell Wall, Chromatography, Chromatography, Affinity, Chromatography, Gas, Chromatography, Paper, Chromatography, Thin Layer, Disaccharides, Fatty Acids/analysis, Glycosides/isolation & purification, Hydrofluoric Acid, Hydrolysis, Immunoelectrophoresis, Lectins, Plant Lectins, Plants, Toxic, Precipitin Tests, Ricinus/immunology, Streptococcus/*analysis, Teichoic Acids/*isolation & purificationPhylogeny
Enzymology7503808Genetic and molecular analysis of the rpoD gene from Lactococcus lactis.Araya T, Ishibashi N, Shimamura S, Tanaka K, Takahashi HBiosci Biotechnol Biochem10.1271/bbb.57.881993Amino Acid Sequence, Bacillus subtilis/chemistry/genetics, Bacterial Proteins/chemistry/*genetics, Base Sequence, Blotting, Southern, Cloning, Molecular, DNA Primase, DNA-Directed RNA Polymerases/chemistry/*genetics, Escherichia coli/chemistry/genetics, Genes, Bacterial, Genetic Complementation Test, Lactococcus lactis/chemistry/*genetics, Molecular Sequence Data, Mutation, Operon, RNA Nucleotidyltransferases/chemistry/genetics, Restriction Mapping, Sigma Factor/chemistry/*genetics, TemperatureGenetics
Enzymology11205941Nisin-producing organisms during traditional 'Fior di latte' cheese-making monitored by multiplex-PCR and PFGE analyses.Moschetti G, Blaiotta G, Villani F, Coppola SInt J Food Microbiol10.1016/s0168-1605(00)00411-62001Bacteriocins/biosynthesis, Cheese/*microbiology, Chromosome Banding, Dairy Products/microbiology, Electrophoresis, Gel, Pulsed-Field/*methods, Gene Amplification, Lactococcus lactis/*genetics/metabolism, Nisin/*biosynthesis/genetics, Polymerase Chain Reaction/*methods, RNA, Ribosomal, 16S/chemistry, RNA, Ribosomal, 23S/chemistryMetabolism
Cultivation11571154Physiological role of beta-phosphoglucomutase in Lactococcus lactis.Levander F, Andersson U, Radstrom PAppl Environ Microbiol10.1128/AEM.67.10.4546-4553.20012001Culture Media, Disaccharides/*metabolism, Fermentation, Glucose/*metabolism, Lactococcus lactis/*enzymology/growth & development/ultrastructure, Mutation, Phosphoglucomutase/genetics/*physiologyMetabolism
Metabolism12200286Formation and conversion of oxygen metabolites by Lactococcus lactis subsp. lactis ATCC 19435 under different growth conditions.van Niel EW, Hofvendahl K, Hahn-Hagerdal BAppl Environ Microbiol10.1128/AEM.68.9.4350-4356.20022002Culture Media/analysis, Hydrogen Peroxide/pharmacology, Lactococcus lactis/growth & development/*metabolism, Oxygen/*metabolism, Pyruvic Acid/*metabolismCultivation
Metabolism15345435The pool of ADP and ATP regulates anaerobic product formation in resting cells of Lactococcus lactis.Palmfeldt J, Paese M, Hahn-Hagerdal B, Van Niel EWAppl Environ Microbiol10.1128/AEM.70.9.5477-5484.20042004Adenosine Diphosphate/*metabolism, Adenosine Triphosphate/*metabolism, Anaerobiosis, Fermentation, Lactococcus lactis/metabolism/*physiology, Maltose/metabolism, Oxidoreductases/metabolismEnzymology
Metabolism18343337Bidirectional cell-surface anchoring function of C-terminal repeat region of peptidoglycan hydrolase of Lactococcus lactis IL1403.Tarahomjoo S, Katakura Y, Satoh E, Shioya SJ Biosci Bioeng10.1263/jbb.105.1162008Cell Adhesion/*physiology, Cell Membrane/*metabolism, Lactococcus lactis/*cytology/*physiology, N-Acetylmuramoyl-L-alanine Amidase/genetics/*metabolism, Protein Structure, Tertiary, Recombinant Fusion Proteins/metabolism, Repetitive Sequences, Amino Acid/physiology
Enzymology20193044Inhibition kinetics of catabolic dehydrogenases by elevated moieties of ATP and ADP--implication for a new regulation mechanism in Lactococcus lactis.Cao R, Zeidan AA, Radstrom P, van Niel EWFEBS J10.1111/j.1742-4658.2010.07601.x2010Adenosine Diphosphate/*metabolism, Adenosine Triphosphate/*metabolism, Alcohol Dehydrogenase/antagonists & inhibitors, *Gene Expression Regulation, Bacterial, Genes, Bacterial, Glyceraldehyde-3-Phosphate Dehydrogenases/antagonists & inhibitors, Kinetics, L-Lactate Dehydrogenase/antagonists & inhibitors, Lactococcus lactis/genetics/*metabolism, Oxidoreductases/*metabolismMetabolism
Phylogeny20833888Lactococcus lactis subsp. tructae subsp. nov. isolated from the intestinal mucus of brown trout (Salmo trutta) and rainbow trout (Oncorhynchus mykiss).Perez T, Balcazar JL, Peix A, Valverde A, Velazquez E, de Blas I, Ruiz-Zarzuela IInt J Syst Evol Microbiol10.1099/ijs.0.023945-02010Animals, Bacterial Proteins/genetics, DNA, Bacterial/genetics, DNA, Ribosomal/genetics, Intestines/*microbiology, Lactococcus lactis/*classification/genetics/*isolation & purification/metabolism, Molecular Sequence Data, Mucus/*microbiology, Oncorhynchus mykiss/microbiology, Phylogeny, RNA, Ribosomal, 16S/genetics, Salmonidae/*microbiologyGenetics
Metabolism22505996Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells.Jounai K, Ikado K, Sugimura T, Ano Y, Braun J, Fujiwara DPLoS One10.1371/journal.pone.00325882012Animals, Bone Marrow/immunology/metabolism, Cell Communication/immunology, Cells, Cultured, Coculture Techniques, Dendritic Cells/immunology/metabolism/*microbiology, Female, Immunologic Factors/immunology/metabolism, Interferon-alpha/immunology/metabolism, Lactic Acid/metabolism, Lactococcus lactis/immunology/isolation & purification/*metabolism, Leuconostoc/immunology/isolation & purification/*metabolism, Mice, Mice, Inbred C57BL, Myeloid Cells/immunology/metabolism/*microbiology, Myeloid Differentiation Factor 88/immunology/metabolism, Pediococcus/immunology/isolation & purification/*metabolism, Streptococcus/immunology/isolation & purification/*metabolism, T-Lymphocytes, Regulatory/immunology/metabolism, Toll-Like Receptor 9/immunology/*metabolismEnzymology
Biotechnology22853547Production, active staining and gas chromatography assay analysis of recombinant aminopeptidase P from Lactococcus lactis ssp. lactis DSM 20481.Stressler T, Eisele T, Schlayer M, Fischer LAMB Express10.1186/2191-0855-2-392012
Phylogeny23178728Lactococcus taiwanensis sp. nov., a lactic acid bacterium isolated from fresh cummingcordia.Chen YS, Chang CH, Pan SF, Wang LT, Chang YC, Wu HC, Yanagida FInt J Syst Evol Microbiol10.1099/ijs.0.045757-02012Bacterial Typing Techniques, Base Composition, Cordia/*microbiology, DNA, Bacterial/genetics, Fatty Acids/analysis, Fermentation, *Food Microbiology, Genes, Bacterial, Lactococcus/*classification/genetics/isolation & purification, Molecular Sequence Data, Nucleic Acid Hybridization, *Phylogeny, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNA, TaiwanBiotechnology
Genetics23542625Characterization of a wild, novel nisin a-producing Lactococcus strain with an L. lactis subsp. cremoris genotype and an L. lactis subsp. lactis phenotype, isolated from Greek raw milk.Parapouli M, Delbes-Paus C, Kakouri A, Koukkou AI, Montel MC, Samelis JAppl Environ Microbiol10.1128/AEM.00436-132013Animals, Base Sequence, Cloning, Molecular, Cluster Analysis, Computational Biology, Genotype, Glycoside Hydrolases/genetics, Greece, Lactococcus lactis/*genetics, Milk/*microbiology, Molecular Sequence Data, *Phenotype, Phylogeny, RNA, Ribosomal, 16S/genetics, Random Amplified Polymorphic DNA Technique, Sequence Analysis, DNA, Species SpecificityPhylogeny
Pathogenicity24239838Immunomodulatory effect of Lactococcus lactis JCM5805 on human plasmacytoid dendritic cells.Sugimura T, Jounai K, Ohshio K, Tanaka T, Suwa M, Fujiwara DClin Immunol10.1016/j.clim.2013.10.0072013Adult, Cells, Cultured, Dendritic Cells/cytology/*drug effects/immunology, Double-Blind Method, Female, Humans, Immunomodulation, Interferon-alpha/biosynthesis/metabolism, Lactococcus lactis/*immunology, Male, Probiotics/*administration & dosage, Surveys and Questionnaires, YogurtMetabolism
Pathogenicity25697605Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.Vandal J, Abou-Zaid MM, Ferroni G, Leduc LGPharm Biol10.3109/13880209.2014.9428672015Anti-Bacterial Agents/pharmacology, Anti-Infective Agents/*pharmacology, Antifungal Agents/pharmacology, Bacteria/drug effects, Biological Products/*pharmacology, Chromatography, High Pressure Liquid, Fungi/drug effects, Indicators and Reagents, Microbial Sensitivity Tests, Ontario, Oxazines, Plant Extracts/pharmacology, Plants/*chemistry, Xanthenes
25746923Oral administration of Lactococcus lactis subsp. lactis JCM5805 enhances lung immune response resulting in protection from murine parainfluenza virus infection.Jounai K, Sugimura T, Ohshio K, Fujiwara DPLoS One10.1371/journal.pone.01190552015Administration, Oral, Animals, Female, *Lactococcus lactis, Lung/*immunology, Mice, Mice, Inbred DBA, Paramyxoviridae Infections/immunology/*prevention & control
Genetics25792049Draft Genome Sequence of Lactococcus lactis subsp. lactis JCM 5805T, a Strain That Induces Plasmacytoid Dendritic Cell Activation.Fujii T, Tomita Y, Ikushima S, Horie A, Fujiwara DGenome Announc10.1128/genomeA.00113-152015
Enzymology26142864Alcohol dehydrogenase activity in Lactococcus chungangensis: application in cream cheese to moderate alcohol uptake.Konkit M, Choi WJ, Kim WJ Dairy Sci10.3168/jds.2015-96972015Alcohol Dehydrogenase/genetics/*metabolism, Animals, Cell Line, Tumor, Cell Survival/drug effects, Cheese/*microbiology, Culture Media/chemistry, Ethanol/metabolism, Food Handling, L-Lactate Dehydrogenase/metabolism, Lactococcus/*enzymology, Mice, Mice, Inbred ICRMetabolism
Metabolism26234407Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus.Sugimura T, Takahashi H, Jounai K, Ohshio K, Kanayama M, Tazumi K, Tanihata Y, Miura Y, Fujiwara D, Yamamoto NBr J Nutr10.1017/S00071145150024082015Administration, Oral, Adult, Cells, Cultured, Dendritic Cells/*immunology, Double-Blind Method, Humans, *Influenza A Virus, H1N1 Subtype, Influenza, Human/immunology/metabolism/*prevention & control/virology, Interferon-alpha/*metabolism, Lactic Acid, Lactococcus lactis/*immunology, Leukocytes, Mononuclear/immunology/metabolism, Middle Aged, *Probiotics, Seasons, Yogurt/microbiologyPathogenicity
Metabolism26623718Lactococcus lactis subsp. lactis JCM 5805 activates natural killer cells via dendritic cells.Suzuki H, Ohshio K, Fujiwara DBiosci Biotechnol Biochem10.1080/09168451.2015.11169222015Animals, Coculture Techniques, Dendritic Cells/*immunology, Female, Killer Cells, Natural/*immunology, Lactococcus lactis/*metabolism, Mice, Mice, Inbred C57BL
Metabolism26723119Aldehyde dehydrogenase activity in Lactococcus chungangensis: Application in cream cheese to reduce aldehyde in alcohol metabolism.Konkit M, Choi WJ, Kim WJ Dairy Sci10.3168/jds.2015-105492015Acetaldehyde/blood/metabolism, Acetates/metabolism, Aldehyde Dehydrogenase/genetics/*metabolism, Animals, Bacterial Proteins/metabolism, Cheese/*microbiology, Ethanol/*metabolism, Female, Humans, Lactococcus lactis/*enzymology, Male, Mice, Species SpecificityEnzymology
Enzymology27003449A Novel Glutamyl (Aspartyl)-Specific Aminopeptidase A from Lactobacillus delbrueckii with Promising Properties for Application.Stressler T, Ewert J, Merz M, Funk J, Claassen W, Lutz-Wahl S, Schmidt H, Kuhn A, Fischer LPLoS One10.1371/journal.pone.01521392016Cloning, Molecular/methods, Glutamyl Aminopeptidase/*genetics, Hydrolases/genetics, Lactobacillus delbrueckii/*genetics, Lactococcus lactis/genetics, Sequence Homology, Amino Acid
Biotechnology27015296Transcriptome analysis of Lactococcus lactis subsp. lactis during milk acidification as affected by dissolved oxygen and the redox potential.Larsen N, Moslehi-Jenabian S, Werner BB, Jensen ML, Garrigues C, Vogensen FK, Jespersen LInt J Food Microbiol10.1016/j.ijfoodmicro.2016.03.0022016Adaptation, Physiological/physiology, Animals, Cheese/microbiology, Down-Regulation, Fermentation, *Food Microbiology, Gene Expression Profiling, Lactococcus lactis/drug effects/*genetics, Milk/*microbiology, Nitrogen/metabolism, Oxidation-Reduction, Oxidative Stress/physiology, Oxygen/metabolism/pharmacologyMetabolism
Enzymology27108177Activities of amylase, proteinase, and lipase enzymes from Lactococcus chungangensis and its application in dairy products.Konkit M, Kim WJ Dairy Sci10.3168/jds.2016-110022016Amylases/*metabolism, Bacterial Proteins/*metabolism, Cheese/*analysis, Fermentation, Lactococcus/*enzymology, Lactococcus lactis/enzymology, Lipase/*metabolism, Peptide Hydrolases/*metabolism, Yogurt/*analysisMetabolism
Metabolism27435538Inhibitory Effect of Lactococcus lactis HY 449 on Cariogenic Biofilm.Kim YJ, Lee SHJ Microbiol Biotechnol10.4014/jmb.1604.040082016*Antibiosis, Bacterial Adhesion, Bacterial Proteins/genetics/metabolism, Biofilms, Dental Caries/*microbiology/*prevention & control, Glucosyltransferases/genetics/metabolism, Humans, Lactococcus lactis/*physiology, Probiotics/metabolism, Streptococcus mutans/enzymology/genetics/*physiologyPathogenicity
Metabolism29414652Administration of Lactococcus lactis strain Plasma induces maturation of plasmacytoid dendritic cells and protection from rotavirus infection in suckling mice.Jounai K, Sugimura T, Morita Y, Ohshio K, Fujiwara DInt Immunopharmacol10.1016/j.intimp.2018.01.0342018Administration, Oral, Animals, Animals, Newborn, Animals, Suckling, Antiviral Agents/*immunology, Cell Differentiation, Cells, Cultured, Dendritic Cells/microbiology/*physiology, Epithelial Cells/*physiology, Female, Interferons/metabolism, Lactococcus lactis/*immunology, Mice, Mice, Inbred BALB C, Mucous Membrane/*pathology, Pancreatitis-Associated Proteins/genetics/metabolism, Rotavirus/*physiology, Rotavirus Infections/*immunology
Pathogenicity29453437Enhancement of immunomodulative effect of lactic acid bacteria on plasmacytoid dendritic cells with sucrose palmitate.Kanayama M, Kato Y, Tsuji T, Konoeda Y, Hashimoto A, Kanauchi O, Fujii T, Fujiwara DSci Rep10.1038/s41598-018-21527-22018Animals, Dendritic Cells/*cytology/*immunology, Immunomodulation/*drug effects, Lactobacillales/*drug effects/*physiology, Mice, Signal Transduction/drug effects, Sucrose/*analogs & derivatives/pharmacology
Pathogenicity29550602Effects of dietary Lactobacillus rhamnosus JCM1136 and Lactococcus lactis subsp. lactis JCM5805 on the growth, intestinal microbiota, morphology, immune response and disease resistance of juvenile Nile tilapia, Oreochromis niloticus.Xia Y, Lu M, Chen G, Cao J, Gao F, Wang M, Liu Z, Zhang D, Zhu H, Yi MFish Shellfish Immunol10.1016/j.fsi.2018.03.0202018Animal Feed/analysis, Animals, Cichlids/anatomy & histology/growth & development/*immunology/microbiology, Diet/veterinary, Gastrointestinal Microbiome/*drug effects, Intestines/drug effects/microbiology, Lactobacillus rhamnosus/*chemistry, Lactococcus lactis/*chemistry, Probiotics/*pharmacology, Random Allocation
Pathogenicity29605632Long-term administration of pDC-Stimulative Lactococcus lactis strain decelerates senescence and prolongs the lifespan of mice.Sugimura T, Jounai K, Ohshio K, Suzuki H, Kirisako T, Sugihara Y, Fujiwara DInt Immunopharmacol10.1016/j.intimp.2018.03.0242018Administration, Oral, Aging/genetics, Animals, Dendritic Cells/*physiology, Female, Humans, Immunity, Interleukin-1beta/genetics/metabolism, Lactococcus lactis/*immunology, Liver/*pathology, Longevity/genetics, Lung/*pathology, Mice, Mice, Mutant Strains, Paresis, Probiotics/*administration & dosage, Skin/*pathology, Virus Diseases/*immunology/microbiologyMetabolism
Enzymology29681403Protective effects of Lactococcus chungangensis CAU 28 on alcohol-metabolizing enzyme activity in rats.Konkit M, Kim K, Kim JH, Kim WJ Dairy Sci10.3168/jds.2017-139922018Acetaldehyde, Animals, Cheese, Ethanol/*metabolism, Lactococcus lactis/*physiology, Male, Rats, Rats, Sprague-DawleyMetabolism
Pathogenicity30071871Efficacy of heat-killed Lactococcus lactis JCM 5805 on immunity and fatigue during consecutive high intensity exercise in male athletes: a randomized, placebo-controlled, double-blinded trial.Komano Y, Shimada K, Naito H, Fukao K, Ishihara Y, Fujii T, Kokubo T, Daida HJ Int Soc Sports Nutr10.1186/s12970-018-0244-92018Creatine Kinase/blood, Dendritic Cells/*immunology, Double-Blind Method, Epinephrine/blood, *Exercise, *Fatigue, Humans, Hydrocortisone/analysis, L-Lactate Dehydrogenase/blood, *Lactococcus lactis, Male, *Probiotics, Respiratory Tract Infections/immunology/*therapy, Young AdultEnzymology
Transcriptome30428393Effects of Lactococcus lactis subsp. lactis JCM5805 on colonization dynamics of gut microbiota and regulation of immunity in early ontogenetic stages of tilapia.Xia Y, Cao J, Wang M, Lu M, Chen G, Gao F, Liu Z, Zhang D, Ke X, Yi MFish Shellfish Immunol10.1016/j.fsi.2018.11.0222018Animals, Gastrointestinal Microbiome/*immunology, Gene Expression Regulation, Developmental/immunology, Lactococcus lactis/*physiology, Probiotics, Random Allocation, Tilapia/*growth & development/immunology/*microbiology, Transcriptome
Metabolism31056324Short communication: Enzymatic perspective of galactosidases reveals variations in lactose metabolism among Lactococcus lactis strains.Yang Y, Li N, Jiang Y, Liu Z, Liu X, Zhao J, Zhang H, Chen WJ Dairy Sci10.3168/jds.2018-159732019Animals, Bacterial Proteins/*metabolism, Fermentation, Galactosidases/*metabolism, Lactococcus lactis/enzymology/growth & development/*metabolism, Lactose/*metabolism, Milk/*microbiologyEnzymology
Phylogeny31644419Lactococcus allomyrinae sp. nov., isolated from gut of larvae of Allomyrina dichotoma.Heo J, Cho H, Tamura T, Saitou S, Park K, Kim JS, Hong SB, Kwon SW, Kim SJInt J Syst Evol Microbiol10.1099/ijsem.0.0034612019Animals, Bacterial Typing Techniques, Base Composition, Cell Wall/chemistry, Coleoptera/*microbiology, DNA, Bacterial/genetics, Fatty Acids/chemistry, Genes, Bacterial, Glycolipids/chemistry, Lactococcus/*classification/isolation & purification, Larva/microbiology, Nucleic Acid Hybridization, Peptidoglycan/chemistry, Phospholipids/chemistry, *Phylogeny, RNA, Ribosomal, 16S/genetics, Republic of Korea, Sequence Analysis, DNA, Vitamin K 2/analogs & derivatives/chemistryTranscriptome
Phylogeny31651376Lactococcus kimchii sp. nov., a new lactic acid bacterium isolated from kimchi.Pheng S, Han HL, Park DS, Chung CH, Kim SGInt J Syst Evol Microbiol10.1099/ijsem.0.0037822020Bacterial Typing Techniques, Base Composition, DNA, Bacterial/genetics, Fatty Acids/chemistry, Fermented Foods/*microbiology, Food Microbiology, Genes, Bacterial, Lactic Acid, Lactococcus/*classification/isolation & purification, Nucleic Acid Hybridization, *Phylogeny, RNA, Ribosomal, 16S/genetics, Republic of Korea, Sequence Analysis, DNABiotechnology
32122783Unexpected effect of probiotics by Lactococcus lactis subsp. lactis against colitis induced by dextran sulfate sodium in mice.Komaki S, Haque A, Miyazaki H, Matsumoto T, Nakamura SJ Infect Chemother10.1016/j.jiac.2020.01.0062020Animals, Colitis, Ulcerative/chemically induced/microbiology/*pathology, Colon/immunology/pathology, Cytokines/blood, Dextran Sulfate, Disease Models, Animal, Female, *Lactococcus lactis, Mice, Mice, Inbred C57BL, Probiotics/*administration & dosage/*adverse effects, Survival Analysis
Phylogeny33503966Antimicrobial Activity of Lactococcus lactis subsp. lactis Isolated from a Stranded Cuvier's Beaked Whale (Ziphius cavirostris) against Gram-Positive and -Negative Bacteria.Suzuki A, Suzuki MMicroorganisms10.3390/microorganisms90202432021
Phylogeny34721319Comparison of 16S rRNA Gene Based Microbial Profiling Using Five Next-Generation Sequencers and Various Primers.Park C, Kim SB, Choi SH, Kim SFront Microbiol10.3389/fmicb.2021.7155002021

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36188Curators of the CIPhttps://brclims.pasteur.fr/brcWeb/souche/detail/1/10529
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
67770Curators of the JCMhttps://jcm.brc.riken.jp/en/
68371Automatically annotated from API 50CH acid
68381Automatically annotated from API rID32STR
68382Automatically annotated from API zym
69479João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.https://microbeatlas.org/MicrobeAtlas 1.0 beta
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120528Curators of the CIPCollection of Institut Pasteur (CIP 70.56)https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%2070.56